CN103705689A - Drug composition for treating gout and gouty arthritis - Google Patents

Drug composition for treating gout and gouty arthritis Download PDF

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Publication number
CN103705689A
CN103705689A CN201310715137.0A CN201310715137A CN103705689A CN 103705689 A CN103705689 A CN 103705689A CN 201310715137 A CN201310715137 A CN 201310715137A CN 103705689 A CN103705689 A CN 103705689A
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parts
gouty arthritis
pharmaceutical composition
fructus
gout
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杨建国
粱梦雪
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GUANGXI NANNING KEGUAN MEDICINE SCIENCE & TECHNOLOGY DEVELOPMENT Co Ltd
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GUANGXI NANNING KEGUAN MEDICINE SCIENCE & TECHNOLOGY DEVELOPMENT Co Ltd
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Abstract

The invention discloses a drug composition for treating gout and gouty arthritis. The drug composition is characterized by comprising the following components in parts by weight: 20-30 parts of gynostemma pentaphylla, 20-30 parts of siraitia grosvenorii, 20-30 parts of barbary wolfberry fruit, 20-30 parts of doubleteeth pubescent angelica root, 20-30 parts of Indian bread, 15-25 parts of virgate wormwood herb, 10-15 parts of pangolin scales, 15-25 parts of garden balsam stem, 15-20 parts of hypoglaucous collett yam rhizome, 15-20 parts of suberect spatholobus stem, 10-15 parts of cassia twig, 10-15 parts of radix astragali, 8-12 parts of pawpaw and 8-10 parts of salvia miltiorrhiza. The drug composition has the functions of dissolving stasis and removing turbidity, dispelling wind and eliminating dampness, removing obstruction to stop pain and harmonizing and tonifying the stomach, has better curative effects on grout, gouty arthritis and the like caused by high uric acid, can improve the immunity of organisms, and does not have toxic or side effect.

Description

A kind of pharmaceutical composition for the treatment of gout, gouty arthritis
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Technical field
The present invention relates to medicine field, be specifically related to a kind of pharmaceutical composition for the treatment of gout, gouty arthritis.
Background technology
Gout, that purine metabolic disturbance causes that uricopoiesis increases and/or the caused one group of disease of underexcretion, modern medicine oneself make the rising of uric acid in blood concentration directly related with purine metabolism obstacle in body through the morbidity of clear and definite gout, be a kind of serious metabolic disease of harm humans health.And gouty arthritis is to cause urate deposition at joint capsule, synovial membrane, cartilage, sclerotin or/and cause with kidney, urate deposition subcutaneous, its hetero-organization a kind of disease of organizing disease damage and inflammatory reaction because uric acid in body increases, it is the key character of gouty arthritis that blood uric acid raises.
Prior art mainly adopt Western medicine in conjunction with dietetic therapy to gout is prevented and treated.As being mainly the high purine food of restriction to the prevention of gout, control is drunk, and should control the arthritis of acute attack in treatment, long-term treatment hyperuricemia again, prevention tophus deposition.In prior art, the Western medicine of clinical employing is divided into treatment gouty arthritis and corrects hyperuricemia two classes, and the former has colchicine, non-thalline AID, glucocorticoid, and they are alleviating pain soon and effectively, reduces inflammation; The latter has probenecid, benzene Australia Ma Long and allopurinol.But all there is toxic and side effects and untoward reaction in various degree in these medicines, as: benzene Australia Ma Longke causes serious hepatic injury and nervous system untoward reaction; Allopurinol is unique xanthine oxidase inhibitor using clinically, can suppress by suppressing xanthine oxidase the generation of uric acid, but it can cause the toxic and side effects such as skin allergy, hepatic injury, life-threatening super quick allergy syndrome., although there is more reliable curative effect, all there is more serious toxic and side effects in the medicine that these are the most frequently used, many patients, because toxicity is large, or have other contraindication, can not take or be difficult to continue and take.
In prior art, Chinese medicine composition becomes treatment gout, the more solution of gouty arthritis, as China Patent No. 02128483 discloses a kind of medicine of the treatment gouty arthritis being comprised of Chinese liquor and Herba Pileae Scriptae, Caulis Spatholobi, Acer buergerianum Miq., black Herba Setariae Plicatae, Pheretima, pepper root, Medulla Tetrapanacis, Radix Clematidis, Rhizoma Homalomenae, Rhizoma Alismatis, Radix Saposhnikoviae, Ramulus Cinnamomi, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae
Thing.Above-mentioned Chinese medicine, according to the theoretical prescription of differentiation of tcm, has good curative effect, and without obvious toxic and side effects.But
Need to after Chinese liquor dipping, make medicated wine, be not suitable for not alcoholic patient, anemia of pregnant woman, heart disease, hyperpietic and take.And gout, that gouty arthritis has the course of disease is long, easily the feature of outbreak repeatedly, in this case, needs untoward reaction Chinese medicine or Chinese medicine and western medicine few, that conveniently take to be used in conjunction with treatment gout, gouty arthritis.
(1) Herb Gynostemmae Pentaphylli, is perennial herbaceous stem rattan wood, claims again that paradise grass, Gospel are careless, superman's ginseng, Herb Gynostemmae Pentaphylli, Herba Gynostemmatis, Herba Gynostemmatis, Pentapanax and gynostemma pentaphyllum makino etc., and Japan is referred to as sweet climing tea.Herb Gynostemmae Pentaphylli is liked the weather of dark and damp gentleness, how wild in concealments place such as sylvan life, brook banks, the perennial draft of climbing up by holding on to.In China, be mainly distributed in Shaanxi flat interest, Hunan, Hubei, the province such as Yunnan, Guangxi, be known as " southern Radix Ginseng ", be grown in the medicinal content of southern Herb Gynostemmae Pentaphylli higher, " the elixir grass " of being called mystery among the people, 1986, State Scientific and Technological Commission was in Spark Program, Herb Gynostemmae Pentaphylli is classified as to position first of " rare Chinese medicine " leaved for development, and on March 5th, 2002, health ministry was listed in health product list.Effect: replenishing QI to invigorate the spleen, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing.[nature and flavor with return through] bitter in the mouth; Micro-sweet; Cool in nature.Return lung; Spleen; Kidney channel [function with cure mainly] body void is weak; Nephrasthenia emission; Leukopenia; Hyperlipemia; Viral hepatitis; Chronic gastroenteritis; Chronic tracheitis.
(2) Radix Angelicae Pubescentis is the dry root of samphire Angelica pubescens Angelica pubescens Maxim.f.biserrata Shan et Yuan.Record in Chinese Pharmacopoeia version in 2010: [nature and flavor with return through] are pungent, bitter, tepor.Return kidney, urinary bladder channel.[function with cure mainly] expelling wind and removing dampness, numbness relieving and pain relieving.For anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache, wind and cold is held wet headache under the arm.
(3) Poria is the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Record in Chinese Pharmacopoeia version in 2010: [nature and flavor with return through] are sweet, light, flat.Return lung, spleen, kidney channel.[function with cure mainly] inducing diuresis to remove edema.For edema, dysuria.
(4) Herba Artemisiae Scopariae is the dry aerial parts of feverfew Artemisia scoparia Waldst. et Kit. Artemisia scoparia Waldst. et Kit. or Herba Artemisiae Scopariae Artemisia capillaris Thunb..Record in Chinese Pharmacopoeia version in 2010: [nature and flavor with return through] are bitter, pungent, are slightly cold.Return spleen, stomach, liver, gallbladder meridian.[function with cure mainly] eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice.For yellow cellulitis oliguria, hygropyrexia heat-damp in summer, eczema pruritus.
(5) Squama Manis is the scute of Manidae animal Squama Manis Manis pentadactyla Linnaeus.According to Chinese Pharmacopoeia version in 2010, record: [nature and flavor with return through]salty, be slightly cold.Return liver, stomach warp. [function with cure mainly]the Xiao Disorder that invigorates blood circulation, the stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis, expel wind to dredge collateral.For Jing Bi WEIJIA, galactostasis, carbuncle sore tumefacting virus, rheumatic arthralgia, paralysis due to windstroke, numbness contracture.(6) Herba speranskiae tuberculatae is the dry herb of ranunculaceae plant Herba clematidis intricatae Clematis intricata Bunge.Record in Guangxi Chinese medicine standard version in 1996: [nature and flavor] are pungent, bitter, temperature.[function with cure mainly] loose wind damp eliminating, removing toxic substances pain relieving.For muscles and bones contracture, rheumatic arthritis, skin infection, rheumatism toxic swelling.
(7) Rhizoma Dioscoreae Hypoglaucaes are the dry rhizome of Dioscoreaceae Plant Powder back of the body Rhizoma Dioscoreae Dioscorea hypoglauca Palibin.Record in Chinese Pharmacopoeia version in 2010: [nature and flavor with return through] hardship, flat.Return kidney, stomach warp.[function with cure mainly] dampness removing goes turbid, wind expelling stagnation removing.For stranguria marked by chyluria, nebulousurine, leukorrhagia, rheumatic arthralgia, articular instability, lumbocrural pain.
(8) Caulis Spatholobi is the dry rattan of leguminous plant spatholobus suberectus Spatholobus suberectus Dunn.Record in Chinese Pharmacopoeia version in 2010: [nature and flavor with return through] are bitter, sweet, temperature.Return liver, kidney channel.[function with cure mainly] blood circulation promoting and enriching, menstruction regulating and pain relieving, relaxing muscles and tendons and activating QI and blood in the collateral.For menoxenia, dysmenorrhea, amenorrhea, rheumatic arthralgia, paralysis and numbness, blood deficiency and yellow complexion.
(9) Ramulus Cinnamomi is the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Record in Chinese Pharmacopoeia version in 2010: [nature and flavor with return through] acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.[function with cure mainly] diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
(10) Radix Astragali is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch) Bge.var.mongholicus (Bge) Hsiao or Radix Astragali Astragalus membranaceus (Fisch) Bge..Record in Chinese Pharmacopoeia version in 2010: [nature and flavor with return through] are sweet, tepor.Return lung, spleen channel.[function with cure mainly] tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promotes the production of body fluid and nourishes blood, the stagnant blood stasis dispelling of row, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, hemiplegia, arthralgia pain is numb, and carbuncle is difficult bursts, and bursts and does not hold back for a long time.
(11) Fructus Chaenomelis is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria Chaenomeles speciosa (Sweet) Nakai.Record in Chinese Pharmacopoeia version in 2010: [nature and flavor with return through] acid, temperature.Return liver, spleen channel.[function with cure mainly] relaxing muscles and tendons and activating QI and blood in the collateral, stomach function regulating removing dampness.For arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, convulsion spasm and pain, beriberi edema.
(12) Radix Salviae Miltiorrhizae is dry root and the rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Record in Chinese Pharmacopoeia version in 2010: [ nature and flavor with return through] hardship, be slightly cold.GUIXIN, Liver Channel.[ function with cure mainly] blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, the relieving restlessness that clears away heart-fire, removing heat from blood eliminating carbuncle.For obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, lump in the abdomen, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, dysmenorrhea amenorrhea, skin infection swells and ache.
(13) Fructus Momordicae is the dry fruit of cucurbitaceous plant Fructus Momordicae Siraiti grosvenorii (Swin gle) C.Jeffrey ex A. M. Lu et Z.Y.Zhang.Record in Chinese Pharmacopoeia version in 2010: [nature and flavor with return through] are sweet, cool.Return lung, large intestine channel.[function with cure mainly] clearing heat and moistening lung, relieving sore throat to recover voice, laxation relieving constipation.For lung-heat type cough, pharyngalgia aphonia, dryness of the intestine constipation.
(14) Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..[nature and flavor with return through] are sweet, flat.Return liver, kidney channel.Record in Chinese Pharmacopoeia version in 2010: [function with cure mainly] nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
Summary of the invention
The object of the invention is for the easily outbreak repeatedly of gout, gouty arthritis, conventional Western medicine often causes some toxic and side effects or occurs the obvious situation of untoward reaction, provide a kind of and can fall blood uric acid, prevent and treat gout, the pharmaceutical composition for the treatment of gouty arthritis, pharmaceutical composition of the present invention is Chinese crude drug, toxic and side effects is little, through pharmacology, clinical verification, has obvious curative effect.And in functional medicine, added appropriate Fructus Momordicae, Fructus Lycii, and not only play corresponding drug effect, can also improve mouthfeel, allow more acceptant this pharmaceutical composition of patient.
The technical solution adopted in the present invention is as follows:
Treat a pharmaceutical composition for gout, gouty arthritis, by the component of following weight portion, formed: Herb Gynostemmae Pentaphylli 20-30 part, Fructus Momordicae 20-30 part, Fructus Lycii 20-30 part, Radix Angelicae Pubescentis 20-30 part, Poria 20-30 part, Herba Artemisiae Scopariae 15-25 part, Squama Manis 10-15 part, Herba speranskiae tuberculatae 15-25 part, Rhizoma Dioscoreae Hypoglaucae 15-20 part, Caulis Spatholobi 15-20 part, Ramulus Cinnamomi 10-15 part, Radix Astragali 10-15 part, Fructus Chaenomelis 8-12 part, Radix Salviae Miltiorrhizae 8-10 part.
The pharmaceutical composition of the above treatment gout, gouty arthritis, is comprised of the component of following weight portion: 25 parts of Herb Gynostemmae Pentaphylli, 30 parts of Fructus Momordicaes, 30 parts of Fructus Lycii, 25 parts of Radix Angelicae Pubescentiss, 25 parts, Poria, 20 parts of Herba Artemisiae Scopariaes, 10 parts of Squama Maniss, 20 parts of Herba speranskiae tuberculataes, 18 parts of Rhizoma Dioscoreae Hypoglaucaes, 18 parts of Caulis Spatholobis, 12 parts of Ramulus Cinnamomi, 12 parts of the Radixs Astragali, 10 parts of Fructus Chaenomeliss, 10 parts of Radix Salviae Miltiorrhizaes.
The pharmaceutical composition of the above treatment gout, gouty arthritis, can add acceptable excipient on various pharmaceuticss required while preparing different dosage form, as disintegrating agent, lubricant, binding agent, cosolvent, thickening agent, antiseptic etc., and be prepared into pharmaceutically acceptable any dosage form with modern Chinese medicine formulation method.For example, after each raw material of Chinese medicine directly can being pulverized, be mixed and made into powder; Also can, by these crude drug waters or with processing accordingly after ethanol extraction and adding the required different auxiliary material of the different solid preparations of preparation, can be made into the multi-form day oral solid preparation such as capsule, tablet, pill, powder, drop pill, granule; Also can prepare the required different auxiliary material of different liquids preparation by these crude drug waters or with processing accordingly after ethanol extraction and adding, can be made into the multi-form oral liquids such as mixture, syrup, Emulsion.
The pharmaceutical composition of the above treatment gout, gouty arthritis, described pharmaceutical composition is preferably made capsule.
The pharmaceutical composition for the treatment of gout, gouty arthritis described in more than one is made the method for capsule, comprises the following steps:
1. according to following weight portion, take component: Herb Gynostemmae Pentaphylli 20-30 part, Fructus Momordicae 20-30 part, Fructus Lycii 20-30 part, Radix Angelicae Pubescentis 20-30 part, Poria 20-30 part, Herba Artemisiae Scopariae 15-25 part, Squama Manis 10-15 part, Herba speranskiae tuberculatae 15-25 part, Rhizoma Dioscoreae Hypoglaucae 15-20 part, Caulis Spatholobi 15-20 part, Ramulus Cinnamomi 10-15 part, Radix Astragali 10-15 part, Fructus Chaenomelis 8-12 part, Radix Salviae Miltiorrhizae 8-10 part;
2. get Poria powder and be broken into fine powder, cross 80 mesh sieves, obtain Poria powder;
3. get Radix Angelicae Pubescentis, Ramulus Cinnamomi extraction volatile oil; Medicinal residues and Herb Gynostemmae Pentaphylli, Fructus Momordicae, Fructus Lycii, Herba Artemisiae Scopariae, Herba speranskiae tuberculatae, Squama Manis, Rhizoma Dioscoreae Hypoglaucae, Caulis Spatholobi, the Radix Astragali, Fructus Chaenomelis, Radix Salviae Miltiorrhizae, add 8-12 times of water gaging, heating extraction 2-3 time, each 1-2 hour, filters, merging filtrate, filtrate is condensed into thick paste, adds Poria powder and appropriate amount of starch under step 2, dry, pulverize, powder gets dry extract;
4. get the volatile oil under step 3, with 6-10, doubly measure betacyclodextrin inclusion his cyclodextrin inclusion complex at double, add in step 3 dried cream powder, mix, incapsulate, obtain.
The present invention according to Chinese Traditional Medicine to the original explanation of gout pathogeny and the rule for the treatment of, in conjunction with the dialectical therapy of modern Chinese medicine, prescription rigorous and scientific.Pharmaceutical composition of the present invention is comprised of Herb Gynostemmae Pentaphylli, Fructus Momordicae, Fructus Lycii, Radix Angelicae Pubescentis, Poria, Herba Artemisiae Scopariae, Squama Manis, Herba speranskiae tuberculatae, Rhizoma Dioscoreae Septemlobae, Caulis Spatholobi, Ramulus Cinnamomi, the Radix Astragali, Fructus Chaenomelis and Radix Salviae Miltiorrhizae, all medicines are harmonious, that the blood stasis dispelling of gathering is altogether dispelled is turbid, the merit of expelling wind and removing dampness, numbness relieving and pain relieving and stomach function regulating revisal, has good treatment gout, gouty arthritis effect.The consumption of pharmaceutical composition of the present invention is also to grope in a large number to sum up, repeatedly study checking preferably and obtain through inventor, shows: the present invention has antiinflammatory, analgesic activity through modern pharmacological research; Through clinical trial, show: the present invention has significant curative effect to gout, gouty arthritis, can obviously reduce Level of Serum Uric Acid, and during medication, do not occur the untoward reaction such as gastrointestinal tract, allergy.
And, in pharmaceutical composition, added appropriate Fructus Momordicae, Fructus Lycii, not only play corresponding drug effect, can also improve mouthfeel, allow more acceptant this pharmaceutical composition of patient.
  
The specific embodiment
Below in conjunction with specific embodiment, the invention will be further described, but do not limit the scope of the invention and range of application:
one, the preparation for the treatment of gout, gouty arthritis medicament composition capsule
embodiment 1
The pharmaceutical composition for the treatment of gout, gouty arthritis is made a method for capsule, comprises the following steps:
1. according to following weight portion, take component: Herb Gynostemmae Pentaphylli 20kg, Fructus Momordicae 30kg, Fructus Lycii 30kg, Radix Angelicae Pubescentis 20kg, Poria 20kg, Herba Artemisiae Scopariae 15kg, Squama Manis 5KG, Herba speranskiae tuberculatae 15kg, Rhizoma Dioscoreae Hypoglaucae 15kg, Caulis Spatholobi 15kg, Ramulus Cinnamomi 10kg, Radix Astragali 10kg, Fructus Chaenomelis 8kg, Radix Salviae Miltiorrhizae 10KG;
2. get Poria powder and be broken into fine powder, cross 80 mesh sieves, obtain Poria powder;
3. get Radix Angelicae Pubescentis, Ramulus Cinnamomi extraction volatile oil; Medicinal residues and Herb Gynostemmae Pentaphylli, Fructus Momordicae, Fructus Lycii, Herba Artemisiae Scopariae, Herba speranskiae tuberculatae, Rhizoma Dioscoreae Hypoglaucae, Caulis Spatholobi, the Radix Astragali, Fructus Chaenomelis, Radix Salviae Miltiorrhizae, add 8 times of water gagings, heating extraction 2 times, each 2 hours, filters, merging filtrate, filtrate is condensed into thick paste, adds Poria powder and appropriate amount of starch under step 2, dry, pulverize, powder gets dry extract;
4. get the volatile oil under step 3, with 6 times of amount betacyclodextrin inclusions his cyclodextrin inclusion complex at double, add in step 3 dried cream powder, mix, incapsulate, obtain.
embodiment 2
The pharmaceutical composition for the treatment of gout, gouty arthritis is made a method for capsule, comprises the following steps:
1. according to following weight portion, take component: Herb Gynostemmae Pentaphylli 30kg, Fructus Momordicae 20kg, Fructus Lycii 20kg, Radix Angelicae Pubescentis 30kg, Poria 30kg, Herba Artemisiae Scopariae 35kg, Squama Manis 10KG, Herba speranskiae tuberculatae 35kg, Rhizoma Dioscoreae Hypoglaucae 20kg, Caulis Spatholobi 20kg, Ramulus Cinnamomi 15kg, Radix Astragali 15kg, Fructus Chaenomelis 12k, Radix Salviae Miltiorrhizae 8KGg;
2. get Poria powder and be broken into fine powder, cross 80 mesh sieves, obtain Poria powder;
3. get Radix Angelicae Pubescentis, Ramulus Cinnamomi extraction volatile oil; Medicinal residues and Herb Gynostemmae Pentaphylli, Fructus Momordicae, Fructus Lycii, Herba Artemisiae Scopariae, Herba speranskiae tuberculatae, Rhizoma Dioscoreae Hypoglaucae, Caulis Spatholobi, the Radix Astragali, Fructus Chaenomelis, add 12 times of water gagings, heating extraction 3 times, each 1 hour, filters, merging filtrate, filtrate is condensed into thick paste, adds Poria powder and appropriate amount of starch under step 2, dry, pulverize, powder gets dry extract;
4. get the volatile oil under step 3, with 10 times of amount betacyclodextrin inclusions his cyclodextrin inclusion complex at double, add in step 3 dried cream powder, mix, incapsulate, obtain.
embodiment 3
The pharmaceutical composition for the treatment of gout, gouty arthritis is made a method for capsule, comprises the following steps:
1. according to following weight portion, take component: Herb Gynostemmae Pentaphylli 25kg, Fructus Momordicae 25kg, Fructus Lycii 25kg, Radix Angelicae Pubescentis 25kg, Poria 25kg, Herba Artemisiae Scopariae 20kg, Squama Manis 15KG, Herba speranskiae tuberculatae 20kg, Rhizoma Dioscoreae Hypoglaucae 18kg, Caulis Spatholobi 18kg, Ramulus Cinnamomi 12kg, Radix Astragali 12kg, Fructus Chaenomelis 10kg, Radix Salviae Miltiorrhizae 9KG;
2. get Poria powder and be broken into fine powder, cross 80 mesh sieves, obtain Poria powder;
3. get Radix Angelicae Pubescentis, Ramulus Cinnamomi extraction volatile oil; Medicinal residues and Herb Gynostemmae Pentaphylli, Fructus Momordicae, Fructus Lycii, Herba Artemisiae Scopariae, Squama Manis, Herba speranskiae tuberculatae, Rhizoma Dioscoreae Hypoglaucae, Caulis Spatholobi, the Radix Astragali, Fructus Chaenomelis, Radix Salviae Miltiorrhizae, add 10 times of water gagings, heating extraction 2 times, each 2 hours, filters, merging filtrate, filtrate is condensed into thick paste, adds Poria powder and appropriate amount of starch under step 2, dry, pulverize, powder gets dry extract;
4. get the volatile oil under step 3, with 8 times of amount betacyclodextrin inclusions his cyclodextrin inclusion complex at double, add in step 3 dried cream powder, mix, incapsulate, obtain.
two, pharmacodynamics test
1. antiinflammatory test: getting 60 of the special-purpose mices of healthy pharmacological testing, is all female body, and body weight 20-25g, divides 4 groups, 15 every group, is divided into matched group (TONGFENGNING oral liquid), 3 groups of embodiment, blank group (normal saline).Laboratory mice, after random packet, successive administration is 3 days.Within the 4th day, respectively organizing every mice is coated with auris dextra and causes inflammation with Oleum Tiglii mixing proinflammatory agent (Oleum Tiglii 2%, dehydrated alcohol 20%, distilled water 5%, ether 73%) 50 μ l.Administration 1 time again after causing scorching half an hour.Cause scorching latter 4 hours clip mice left and right ears, with card punch punching, get left and right ear and be equal to position, accurately weigh, using left and right ear weight difference as swelling, evaluate the impact of medicine on Fructus Crotonis oiliness inflammation.The results are shown in Table 1.
Table 1 Oleum Tiglii causes the antiinflammatory action result table of mice auricle swelling method
Group Swelling (mg)
Matched group 3.5±1.7
1 group of embodiment 2.6±0.6
3 groups of embodiment 2.7±0.7
Blank group 6.8±2.5
Result shows: 1 group of the embodiment of the present invention, 3 groups of embodiment and matched group, acute inflammation Fructus Crotonis oiliness inflammation and chronic inflammatory disease are all had to obvious inhibitory action (P<0.05), and 3 groups of 1 group of this embodiment and bright embodiment are slightly stronger than matched group to the inhibitory action of inflammation.
2. analgesic test: getting 60 of the special-purpose mices of healthy pharmacological testing, be all female body, and body weight 20-25g, divides 4 groups, 10 every group, is divided into matched group (TONGFENGNING oral liquid), 3 groups of embodiment, blank group (normal saline).Respectively continuous 7 days of administration of each group after grouping, after last administration 1 hour, lumbar injection 0.8% acetic acid 0.2m1/ only, recorded writhing number of times in 5-20 minutes.The results are shown in Table 2.
Table 2 mouse writhing method analgesic test result table
Group Writhing number of times (inferior)
Matched group ?28.5±4.5
1 group of embodiment 28.2±2.7
2 groups of embodiment 28.4±2.7
Blank group 55.6±5.8
Result shows: 2 groups of 1 group of the embodiment of the present invention, embodiment are compared with matched group, all can significantly reduce mouse writhing number of times (P<0.05), and 2 groups of 1 group of the real embodiment of the present invention, embodiment compare with matched group, and writhing number of times is suitable.Show that analgesic effect of the present invention and matched group are suitable.
Above result of the test shows that the present invention has antiinflammatory, analgesic activity.
three, clinical trial
1. case selection standard
(1) clinical manifestation is because of Changes in weather, and the red and swollen heat pain of big toe, toe toe joint or instep unknown cause occurs suddenly, and often in sudden onset at night, and sufferer body temperature is lower than 38 ℃;
(2) blood uric acid (UA) is higher than 7.0mg/dl.
Possess above-mentioned two, the age is 25-70 year person simultaneously.
2. therapeutic scheme
The 40 routine gouts that meet above-mentioned standard, gouty arthritis companion hyperuricemia patients are divided into 3 groups of embodiment groups and 1 group of matched group, every group of 10 examples at random by medical order.
(1) embodiment group: by the above-mentioned embodiment preparing 1, embodiment 2, embodiment 3 samples, for clinical trial.Oral, one time 4,3 times on the one.The course for the treatment of: medication 4 weeks.
(2) matched group: Allopurinol Tablets.The 1st week: each 0.05g(half sheet), every day 3 times; The 2nd week: each 0.1g(1 sheet), every day 3 times; 2-4 week: each 0.2-0.3g(2-3 sheet), every day 3 times.The course for the treatment of: medication 4 weeks.
3. therapeutic outcome
After medication 4 weeks, patient's ordinary circumstance and blood uric acid are detected.
(1) ordinary circumstance is observed
Embodiment group: after weather turns cold suddenly, substantially without hands big toe, toe joint or instep redness, twinge, burning pain phenomenon occur suddenly, joint function recovery, patient's body constitution strengthens, and has no adverse reaction.
Matched group: after weather turns cold suddenly, substantially without hands big toe, toe joint or instep redness, twinge, burning pain phenomenon occur suddenly, joint function recovery, but during medication there is the untoward reaction such as gastrointestinal reaction, allergy in some patients were.
(2) detect data comparison
Measure respectively patient self take medicine before and after Level of Serum Uric Acid, refer to following table:
Blood uric acid mean change (mg/dl) before and after the treatment of table 3 embodiment group
Group Stage n (x±s) P value
Embodiment 1 Before treatment 10 9.33±1.34 ﹤0.05
? After treatment 10 5.87±1.21 ?
Embodiment 2 Before treatment 10 9.28±1.37 ﹤0.05
? After treatment 10 5.82±1.22 ?
Embodiment 3 Before treatment 10 9.46±1.37 ﹤0.05
? After treatment 10 5.71±1.19 ?
Level of Serum Uric Acid comparison (mg/dl) falls in table 4 embodiment group and matched group
Group n (x±s) P value
Embodiment group 1 10 5.89±1.19* ﹤0.05
Embodiment group 2 10 5.83±1.21* ﹤0.05
Embodiment group 3 10 5.71±1.23* ﹤0.05
Matched group 10 5.78±1.05 ?
4. brief summary: the present invention is by the clinical trial certificate of 3 embodiment groups, and patient self treats the change of front and back Level of Serum Uric Acid, and difference has highly significant, illustrate that the present invention can obviously reduce blood uric acid, it is suitable with matched group that it reduces blood uric acid effect, and patient's favourable prognosis, has no adverse reaction.Though and matched group can obviously reduce blood uric acid, have untoward reaction during medication.

Claims (6)

1. a pharmaceutical composition for the treatment of gout, gouty arthritis, it is characterized in that, by the component of following weight portion, formed: Herb Gynostemmae Pentaphylli 20-30 part, Fructus Momordicae 20-30 part, Fructus Lycii 20-30 part, Radix Angelicae Pubescentis 20-30 part, Poria 20-30 part, Herba Artemisiae Scopariae 15-25 part, Squama Manis 10-15 part, Herba speranskiae tuberculatae 15-25 part, Rhizoma Dioscoreae Hypoglaucae 15-20 part, Caulis Spatholobi 15-20 part, Ramulus Cinnamomi 10-15 part, Radix Astragali 10-15 part, Fructus Chaenomelis 8-12 part, Radix Salviae Miltiorrhizae 8-10 part.
2. treat according to claim 1 the pharmaceutical composition of gout, gouty arthritis, it is characterized in that, by the component of following weight portion, formed: 25 parts of Herb Gynostemmae Pentaphylli, 30 parts of Fructus Momordicaes, 30 parts of Fructus Lycii, 25 parts of Radix Angelicae Pubescentiss, 25 parts, Poria, 20 parts of Herba Artemisiae Scopariaes, 10 parts of Squama Maniss, 20 parts of Herba speranskiae tuberculataes, 18 parts of Rhizoma Dioscoreae Hypoglaucaes, 18 parts of Caulis Spatholobis, 12 parts of Ramulus Cinnamomi, 12 parts of the Radixs Astragali, 10 parts of Fructus Chaenomeliss, 10 parts of Radix Salviae Miltiorrhizaes.
3. according to the pharmaceutical composition for the treatment of gout, gouty arthritis described in claim 1 or 2, it is characterized in that, described pharmaceutical composition is made pharmaceutically acceptable any dosage form.
4. according to the pharmaceutical composition for the treatment of gout, gouty arthritis described in claim 1 or 2, it is characterized in that, described pharmaceutical composition is made capsule.
5. the pharmaceutical composition for the treatment of as claimed in claim 4 gout, gouty arthritis is made a method for capsule, comprises the following steps:
(1) according to following weight portion, take component: Herb Gynostemmae Pentaphylli 20-30 part, Fructus Momordicae 20-30 part, Fructus Lycii 20-30 part, Radix Angelicae Pubescentis 20-30 part, Poria 20-30 part, Herba Artemisiae Scopariae 15-25 part, Squama Manis 10-15 part, Herba speranskiae tuberculatae 15-25 part, Rhizoma Dioscoreae Hypoglaucae 15-20 part, Caulis Spatholobi 15-20 part, Ramulus Cinnamomi 10-15 part, Radix Astragali 10-15 part, Fructus Chaenomelis 8-12 part, Radix Salviae Miltiorrhizae 8-10 part;
(2) get Poria powder and be broken into fine powder, cross 80 mesh sieves, obtain Poria powder;
(3) get Radix Angelicae Pubescentis, Ramulus Cinnamomi extraction volatile oil; Medicinal residues and Herb Gynostemmae Pentaphylli, Fructus Momordicae, Fructus Lycii, Herba Artemisiae Scopariae, Squama Manis, Herba speranskiae tuberculatae, Rhizoma Dioscoreae Hypoglaucae, Caulis Spatholobi, the Radix Astragali, Fructus Chaenomelis, Radix Salviae Miltiorrhizae, add 8-12 times of water gaging, heating extraction 2-3 time, each 1-2 hour, filters, merging filtrate, filtrate is condensed into thick paste, adds Poria powder and appropriate amount of starch under step (2), dry, pulverize, powder gets dry extract;
(4) get the volatile oil under step (3), with 6-10, doubly measure betacyclodextrin inclusion his cyclodextrin inclusion complex at double, add in step (3) dried cream powder, mix, incapsulate, obtain.
6. according to the pharmaceutical composition of arbitrary described treatment gouty arthritis in claim 1 to 5, it is characterized in that the purposes of described pharmaceutical composition in preparation gout, gouty arthritis medicine.
CN201310715137.0A 2013-12-23 2013-12-23 Drug composition for treating gout and gouty arthritis Pending CN103705689A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103931846A (en) * 2014-04-25 2014-07-23 杨剑礼 Health care tea capable of reducing uric acid
CN106620068A (en) * 2017-02-27 2017-05-10 普洱淞茂滇草六味制药股份有限公司 Anti-gout medicine composition, as well as preparation method, preparation and application thereof
CN108078935A (en) * 2017-12-29 2018-05-29 南宁市共健源健康科技有限公司 Treat chewable tablets of gout and preparation method thereof
CN111991530A (en) * 2020-09-21 2020-11-27 广西谢郡堂科技股份有限公司 Medicine for treating gout and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
李红琴等: "绞股蓝对小鼠一过性高尿酸血症的作用", 《湖北中医学院学报》 *
郜顺兴等: "中药治疗痛风性关节炎的计量分析", 《河南中医》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103931846A (en) * 2014-04-25 2014-07-23 杨剑礼 Health care tea capable of reducing uric acid
CN103931846B (en) * 2014-04-25 2015-09-16 杨剑礼 A kind of anti-trioxypurine health protection tea
CN106620068A (en) * 2017-02-27 2017-05-10 普洱淞茂滇草六味制药股份有限公司 Anti-gout medicine composition, as well as preparation method, preparation and application thereof
CN108078935A (en) * 2017-12-29 2018-05-29 南宁市共健源健康科技有限公司 Treat chewable tablets of gout and preparation method thereof
CN111991530A (en) * 2020-09-21 2020-11-27 广西谢郡堂科技股份有限公司 Medicine for treating gout and preparation method thereof

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