CN104172159A - Composition with auxiliary protection effect on alcoholic liver injury and preparation method thereof - Google Patents

Composition with auxiliary protection effect on alcoholic liver injury and preparation method thereof Download PDF

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CN104172159A
CN104172159A CN201410356846.9A CN201410356846A CN104172159A CN 104172159 A CN104172159 A CN 104172159A CN 201410356846 A CN201410356846 A CN 201410356846A CN 104172159 A CN104172159 A CN 104172159A
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何俊保
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BEIJING ZHONGTAI TIANHE SCIENCE AND TECHNOLOGY Co Ltd
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BEIJING ZHONGTAI TIANHE SCIENCE AND TECHNOLOGY Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The invention discloses a composition with an auxiliary protection effect on an alcoholic liver injury and a preparation method of the composition. The composition with the auxiliary protective effect on the alcoholic liver injury is mainly prepared from the following raw materials in parts by weight: 57.5-172.5 parts of kudzuvine root extract, 22.5-67.5 parts of semen hoveniae extract, 35-105 parts of salvia miltiorrhiza extract, 18-57 parts of turmeric extract and 7.5-22.5 parts of ammonium glycyrrhetate. The raw materials respectively have anti-lipid peroxidation effect and protective effect on the liver. Functional tests show that the composition with the auxiliary protection effect on the alcoholic liver injury has better liver protection effect compared with the same dose of single kudzuvine root extract preparation and single semen hoveniae extract preparation, and liver fatty degeneration and liver lipid peroxidation which are caused by the alcoholic liver injury can be obviously alleviated. The composition with the auxiliary protection effect is prepared by adopting a scientific and reasonable production process, is definite in functions, controllable in quality and safe to take and is applicable to a large group of people suffering from the alcoholic liver injury.

Description

A kind of composition and method of making the same alcoholic liver injury to auxiliary protection function
Technical field
The present invention relates to a kind of composition and method of making the same that alcoholic liver injury is had to auxiliary protection function, belong to health food technology field.
Background technology
Alcoholic liver injury (alcoholic liver disease, ALD) is the Poisoning liver diseases causing because of long-term excessive consumption of alcohol, and ALDShi western countries patient causes the main reason of cirrhosis.At China's AML, there is in recent years the trend increasing gradually, become the second largest hepatopathy cause of disease that is only second to virus hepatitis at present.
AML is due to the liver diseases due to long-term heavy drinking, initial stage is usually expressed as fatty liver, and then can develop into alcoholic hepatitis, alcoholic fibrosis and alcoholic cirrhosis, even while seriously indulging in excessive drinking, can bring out extensive necrosis of liver cells liver failure.So far also there is no clinically effectively to prevent and treat the ideal medicament that development occurs liver diseases.Think at present, alcohol has the hepatocellular toxic action of direct infringement, is the fundamental cause that causes hepatic lesion, and oxidative stress and lipid peroxidation are that alcohol causes one of key factor of hepar damnification.80～the 150g that drinks general every day, can cause hepatic injury in continuous 5 years; Heavy drinking is more than 20 years, and 40%～50% cirrhosis can occur.
The pathogenesis of ALD is not fully aware of at present, and the lipid peroxidation of free radical and mediation thereof is considered to topmost paathogenic factor.Ethanol can produce a large amount of free radicals: O when liver metabolism 2 -, H 2o 2, OH -, C 2h 5o -and C 2h 5oH -, excessive free radical can cause liver plasma membrane generation peroxidatic reaction of lipid, makes cell membrane and organelle structural deterioration, membrane fluidity is not normal; A large amount of liver cell endoenzymes (ALT, AST) are released into blood, and can make to remove free radical enzyme (SOD, GPx) and exhaust, hepatocellular injury further increases the weight of, dysfunction of liver, fat metabolic disturbance, hepatic tissue official fat-like and the sex change of cavity sample, finally cause liver cell extensive necrosis, and cellular swelling is dead.Therefore, remove free radical inhibition peroxidatic reaction of lipid, protection liver cell, recovers liver normal function, is the key that control ALD occurs and develops.
Summary of the invention
The object of this invention is to provide a kind of composition and method of making the same alcoholic liver injury to auxiliary protection function.
The present invention also provides the purposes of described composition, is mainly used in health food or functional food.
A kind of composition alcoholic liver injury to auxiliary protection function of the present invention, comprises that the raw material of following weight portion forms:
Kudzu root extract 57.5-172.5 part, raisin tree seed extract 22.5-67.5 part, Salvia root P.E 35-105 part, Turmeric P.E 18-57 part, ammonium glycyrrhetate 7.5-22.5 part.
Wherein, preferred raw material weight umber is:
115 parts of kudzu root extracts, 45 parts of raisin tree seed extracts, 70 parts of Salvia root P.Es, 37.5 parts of Turmeric P.Es, 15 parts of ammonium glycyrrhetates.
Composition of the present invention, also contains one or more auxiliary materials in microcrystalline cellulose, PVPP, dolomol, dextrin, sucrose, or the conventional pharmaceutical adjunct in other this areas.
Composition of the present invention, prepares by the following method: kudzu root extract, raisin tree seed extract, Salvia root P.E, Turmeric P.E, ammonium glycyrrhetate are crossed respectively to 80 mesh sieves, add auxiliary material, through steps such as batching, mixing, make preparation.
Composition primary raw material effect of the present invention is as follows:
1, kudzu root extract: the root of kudzu vine is sweet, pungent, cool.Return spleen, stomach, lung channel.Relieving muscles to expel heat, promotes the production of body fluid to quench thirst, and promoting eruption rises positive antidiarrheal, clearing and activating the channels and collaterals, relieving alcoholism.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hot dysentery, has loose bowels, dizziness and headache, hemiplegia, chest impediment and cardialgia, in wine poison wound.The root of kudzu vine is the traditional Sobering-up Chinese medicine of China, and its main component is flavone compound, containing daidzin, Daidzein and Puerarin, has the effect of protection liver cell 26S Proteasome Structure and Function integrality, and alcoholic liver injury is had to certain therapeutic action.Feng Qin etc. study discovery, root of kudzu vine water extraction liquid can significantly reduce alcoholic liver injury rat model serum alt, AST content, significantly improve SOD content and reduction MDA content in liver organization, suppressing lipid peroxidation injury may be one of effect link of root of kudzu vine resisting alcoholic hepatic injury.The root of kudzu vine is loose can be improved alcoholic liver injury Mouse Liver microsome Cytochrome P450 (CYP450) content and reduce Cytochrome P450-2E1 (CYP2E1) activity, and acute alcohol liver damage Mouse Liver function is had to optimum intervention effect.Puerarin has the effect that reduces acute alcoholism SD rat Ethanol concentration in rat blood, and alcoholic liver injury is had to protective effect, alleviates the murder by poisoning of ethanol to health.Root of kudzu vine Radix Glycyrrhizae compound formulation can obviously reduce TG content in alcoholic hepatic injury liver tissues of rats, rising GSH content, and can improve hepatic cell fattydegeneration, alcoholic liver injury is had to prevention effect.
2, raisin tree seed extract: hoveniae semoveniae semen is the mature seed of northern trifoliate orange Dulcis, trifoliate orange Dulcis, comospore trifoliate orange Dulcis.Main component is saponin(e, alkaloid and flavones ingredient.The traditional Chinese medical science thinks that hoveniae semoveniae semen has reducing fever and causing diuresis, and the effect of relieving alcoholism cures mainly the diseases such as wine disease, dysphoria with smothery sensation, thirsty, vomiting, difficulty in urination and defecation.Pharmacological research shows, northern trifoliate orange Dulcis can extend the drunk time and shorten because of the drunk length of one's sleep of causing, and alcohol metabolism in acceleration bodies suppresses of flaccid muscles due to ethanol, important enzyme in activation alcohol metabolism process.Hoveniae semoveniae semen methanolic extract can improve acute hepatic injury mice GSH anti-oxidation function, strengthen the GSH association reaction of GST catalysis, increase SOD, CAT active, the acute liver due to antagonism ethanol.Hoveniae semoveniae semen aqueous extract in advance gastric infusion can stop the mouse liver MDA due to ethanol to raise and GSH decline; and cholesterol, triglycerides due to energy Anti-ethanol increase; point out it to alcohol, to cause mouse liver lipid peroxidation and there is protective effect, and likely delay and prevent the formation of the fatty liver due to ethanol.Hoveniae semoveniae semen general flavone can significantly reduce ALT in rat blood serum, AST, TNF-α, HA, LN content, reduce hepatic tissue and produce MDA, rising IL-10 level, alleviates the inflammatory reaction that alcohol causes, and formation that may be to anti-hepatic fibrosis, the hepatic injury that alcohol is caused has good preventive and therapeutic effect.
3, Salvia root P.E: the red sage root, hardship, is slightly cold.The thoughts of returning home, Liver Channel.There is promoting blood circulation, inducing meastruation to relieve menalgia, the relieving restlessness that clears away heart-fire, the cool blood carbuncle that disappears, for chest impediment and cardialgia, gastral cavity abdominal rib Tong ， lumps in the chest and abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea is through closing, and sore swells and ache.Effective component in red sage mostly is fat-soluble tanshinone and water miscible danshinolic acid class.Motherland's medical science thinks, it is long-pending that the alcohol impariment of the liver mostly is the wine poison stasis of blood, due to damp and hot stifling liver, all has the factor of the stasis of blood from the cause of disease, pathological analysis.The pharmacological action of the red sage root is promoting blood circulation and removing blood stasis just, and modern pharmacology is thought and improved microcirculation by the expansible blood vessel of the red sage root, suppresses blood coagulation, increases internal organs CBF and reduces the effects such as blood viscosity.The red sage root also has antioxidation, by improving the activity of superoxide dismutase in blood, and oxygen radical in scavenger-cell, anti-oxidative defense ability in reinforcement, to improve cell membrane stability, thus Cell protection.The red sage root truly has protective effect to acute alcohol liver damage.
Studies show that Tanshinone II acan reduce hepatic injury mice serum ALT, AST, reduce the content of hepatic tissue MDA, remove oxygen radical, performance antioxidation activity, there is obvious liver protection.The red sage root can alleviate hepatic cell fattydegeneration, the necrosis that alcohol causes, lowers hepatic tissue toll sample acceptor 4 (TLR4) mrna expressions and heme oxygenase-1 (HO-1) mrna expression, and can make TLR4 positive cell number obviously reduce.The red sage root can be by reducing the caused hepatic injury of alcohol on the impact of TLR4 signal transduction path.
4, Turmeric P.E: turmeric, acrid, bitter, warm.Return spleen, Liver Channel.Broken blood gas, inducing meastruation to relieve menalgia.For the shouting pain of the chest side of body, chest impediment and cardialgia, dysmenorrhoea is through Bi ， Disorder lump in the abdomen, and rheumatism is takeed on arm pain, tumbling and swelling.Curcumin is its main chemical compositions.Modern pharmacological research shows, the mechanism of action of curcumin anti-liver injury is mainly manifested in and removes liver free radical, suppresses inflammation reaction and suppress the several respects such as Hepatic Stellate Cell Activation.Curcumin can reduce MDA content in liver injury model animal blood serum ALT, AST, NO content and hepatic tissue, has obvious hepatoprotective effect.Curcumin can pass through to suppress the expression of NF-κ B in alcoholism lipid peroxidation in rats and hepatic tissue, thereby alleviates or prevent and treat the hepatic injury of alcohol induction.Curcumin can alleviate the liver fat sex change of alcohol induction, suppress the release of serum transaminase, improve disorders of lipid metabolism, and suppresses the oxidative damage of accumulating, slow down hepatic tissue of ROS in liver, thereby the hepatic injury of alcohol induction is shielded.
5, ammonium glycyrrhetate: glycyrrhizic acid is the active ingredient of glycyrrhiza uralensis fisch, has anti-inflammatory, antiallergy and liver-protective effect.Radix Glycyrrhizae acids medicine is clinical conventional hepatic.Ammonium glycyrrhetate is ammonium glycyrrhizinate salt material.Modern pharmacological research shows, various Radix Glycyrrhizae acids mechanisms of drug action are basically identical, and the enoxolone generating through glycuronidase effect in vivo has protection liver plasma membrane, anti-inflammatory, adjusting immunity, regulates the effects such as cytochrome P 450 Enzyme, removing toxic substances.Glycyrrhizic acid can suppress alcohol metabolism product, alleviates the immunological liver injury due to alcohol metabolism thing.Glycyrrhizic acid can be removed by raising the activity of free radical enzyme; the damage of the peroxidatic reaction of lipid of inhibition free radical mediated to liver, Cell protection film, alleviates degeneration of liver cells necrosis and alleviates; thereby accelerate the recovery of cell function, alcoholic liver injury is played a protective role.
Composition of the present invention is made following oral formulations: capsule, tablet, granule or oral liquid, be preferably capsule or tablet.
The present invention also provides the preparation method of above-mentioned composition, and the above-mentioned method of making various oral formulations adopts this area common method, and for example the preparation method of present composition capsule, comprises the steps:
(1) supplementary material in formula is all crossed 80 mesh sieves, standby.Industrial water is purified water, should meet 2010 editions purified water requirements of < < Chinese pharmacopoeia > >; Producing ethanol used is food grade ethanol, should meet the requirement of GB 10343-2008 edible alcohol.
(2) by formula inventory, accurately take kudzu root extract, raisin tree seed extract, Salvia root P.E, Turmeric P.E, ammonium glycyrrhetate, microcrystalline cellulose; put in mixer and mix, then add ethanolic solution to make in right amount softwood, with oscillating granulator, granulate; sieve.
(3) wet granular is laid in stainless steel disc uniformly, puts forced air drying at 60 ℃ ± 3 ℃ in air dry oven, pellet moisture should be controlled in 6%.Dried particle is sieved to whole, standby.
(4) by formula inventory, accurately take dolomol, first and dried particle equivalent increases progressively mixes after three times, and whole materials are added to total mixed 30min in total mixing device.
(5) filling on automatic capsule filling machine.Populated capsule is carried out on capsule polisher to polishing.
(6) packing, check obtain standard compliant product.
The present invention also provides described composition in the application for the preparation of alcoholic liver injury being had to health food or the functional food of auxiliary protection function.
The present invention also provides described composition preparing the health food of sub-health state or the application in functional food.
In addition, the present invention also provides the functional food that contains above-mentioned composition.
The invention has the advantages that: select the raw material with the effect of auxiliary protection alcoholic liver injury; formula Design is scientific and reasonable; preparation process simple possible; quality controllable; safe; than the single kudzu root extract preparation under same dose and single raisin tree seed extract preparation, there is the more excellent effect that improves alcoholic liver injury symptom, be suitable for vast alcoholic liver injury crowd's use.
The specific embodiment
By the following specific examples further illustrate the invention, and the embodiment wherein exemplifying is only to explanation of the present invention, and can not limit the scope of the invention by any way.In following examples, kudzu root extract (Puerarin>=10%), raisin tree seed extract (10:1), Turmeric P.E (10:1) is all purchased from Yuan Sen bio tech ltd, Xi'an; Salvia root P.E (Tanshinone I I a>=3%), purchased from San Jiang bio tech ltd, Xi'an; Ammonium glycyrrhetate (>=75%), purchased from Shaanxi Fu Jie pharmaceutcal corporation, Ltd.
Embodiment 1
Formula: kudzu root extract 115g, raisin tree seed extract 45g, Salvia root P.E 70g, Turmeric P.E 37.5g, ammonium glycyrrhetate 15g, microcrystalline cellulose 56g, dolomol (additional) 1.5g.
Preparation method:
1, the supplementary material in formula is all crossed 80 mesh sieves, standby.Industrial water is purified water, should meet 2010 editions purified water requirements of < < Chinese pharmacopoeia > >; Producing ethanol used is food grade ethanol, should meet the requirement of GB 10343-2008 edible alcohol.
2, by formula inventory, accurately take kudzu root extract, raisin tree seed extract, Salvia root P.E, Turmeric P.E, ammonium glycyrrhetate, microcrystalline cellulose; put in mixer and mix, then add ethanolic solution to make in right amount softwood, with oscillating granulator, granulate; sieve.
3, wet granular is laid in stainless steel disc uniformly, puts forced air drying at 60 ℃ ± 3 ℃ in air dry oven, pellet moisture should be controlled in 6%.Dried particle is sieved to whole, standby.
4, by formula inventory, accurately take dolomol, first and dried particle equivalent increases progressively mixes after three times, and whole materials are added to total mixed 30min in total mixing device.
5, filling on automatic capsule filling machine.Populated capsule is carried out on capsule polisher to polishing.
6, packing, check obtain standard compliant product.
Embodiment 2:
Formula: kudzu root extract 172.5g, raisin tree seed extract 22.5g, Salvia root P.E 62g, Turmeric P.E 18g, ammonium glycyrrhetate 7.5g, microcrystalline cellulose 185g, PVPP 30g, dolomol 2.5g, film coating pre-mix dose 15g.
Preparation method: supplementary material mixes, sieves, and compressing tablet is made tablet, and package test obtains meeting standardized product.
Embodiment 3:
Formula: kudzu root extract 57.5g, raisin tree seed extract 67.5g, Salvia root P.E 105g, Turmeric P.E 30g, ammonium glycyrrhetate 22.5g, dextrin 217.5g.
Preparation method: supplementary material mixes, sieves, granulates, and granulation agent, package test obtains meeting standardized product.
Embodiment 4:
Formula: kudzu root extract 125g, raisin tree seed extract 55g, Salvia root P.E 35g, Turmeric P.E 57g, ammonium glycyrrhetate 10.5g, sucrose 90g.
Preparation method: supplementary material mixes, adds water and dissolves in right amount, filters, and makes oral liquid.Package test obtains standard compliant product.
By toxicological test and function test, further set forth the present invention below, due to capsule involved in the present invention, tablet, granule, oral liquid, except formulation, auxiliary material difference, primary raw material, every day, amount, functional component were all identical, do not affect safety and the function of product, therefore select the product of embodiment 1 preparation to carry out toxicity and function test, no longer other formulations repeated.
Test example 1 toxicological test
The above embodiment of the present invention product promulgates that according to the Ministry of Public Health check of < < health food and assessment technique standard > > (version in 2003) related request carry out toxicology test, and concrete test method is shown in above-mentioned standard.
Toxicological experiment proves, the maximum tolerated dose of Kunming mouse acute oral is greater than 15.0g/kgbw, belongs to nontoxic level; Three genetic toxicity tests (Salmonella reversion test, PCEMNR micronucleus test, mouse sperm deformity test), result is all negative.With the Capsule content of 2.3g/kgbw, 3.4g/kgbw, 4.5g/kgbw (be equivalent to respectively human body RD 50,75,100 times) to rat oral gavage 30 days, duration of test, each treated animal grows well, each dosage of sample is to rat body weight, body weight gain, average food-intake and food utilization and the comparison of solvent control group, without significant difference (P>0.05).Each dosage group hematological indices, blood biochemistry index, dirty body ratio and the comparison of solvent control group, there was no significant difference (P>0.05).Solvent control group has no the abnormal change relevant with sample with high dose group gross anatomy and histopathological examination.
Test example 2 function tests
Test objective: whether check product has auxiliary protection function to alcoholic liver injury to animal
The capsule that test material: embodiment 1 makes
Dosage arranges and selects: dosage group (primary raw material content is 0.38g/kgbw), present composition high dose group (primary raw material content is 0.76g/kgbw), kudzu root extract group (kudzu root extract content is 0.76g/kgbw), raisin tree seed extract group (raisin tree seed extract content is 0.76g/kgbw) in blank group, model control group, present composition low dose group (primary raw material content is 0.19g/kgbw), the present composition.Wherein the basic, normal, high dosage group of the present composition is equivalent to respectively 5,10,20 times of human body RD.
Test method: promulgate, in the check of < < health food and assessment technique standard > > (version in 2003), chemical damage to be had to the method for inspection of auxiliary protection function according to the Ministry of Public Health.
Result of the test:
1, the impact of given the test agent on Mouse Weight
Each given the test agent is through mouse stomach 30d, there are no significant difference (P>0.05) that blank group, model control group, kudzu root extract group, raisin tree seed extract group, the basic, normal, high dosage group of the present composition group mesosome method of double differences be different, the results are shown in Table 1.
Table 1 given the test agent on the impact of Mouse Weight (n=10, )
2, the impact of given the test agent on mouse liver biochemical indicator
In model control group liver, MDA, TG content are all significantly higher than blank group (P<0.01 or P<0.05), GSH activity is significantly lower than blank group (P<0.05), and experiment modeling is successful.With model control group comparison, kudzu root extract group and raisin tree seed extract group all significantly reduce MDA content (P<0.05) in alcoholic liver injury animal's liver, GSH active (P<0.05) in its liver that significantly raises; Present composition low dose group can significantly reduce MDA content (P<0.05) in alcoholic liver injury animal's liver, GSH active (P<0.05) in its liver that significantly raises; The middle and high dosage group of the present composition can significantly reduce MDA in alcoholic liver injury animal's liver, TG content (P<0.05 or P<0.01), GSH active (P<0.05 or P<0.01) in its liver that significantly raises; In present composition high dose group animal's liver, MDA, TG content are significantly lower than kudzu root extract group and raisin tree seed extract group (P<0.05), and GSH activity is significantly higher than kudzu root extract group and raisin tree seed extract group (P<0.05).Present composition group is better than single kudzu root extract preparation and the single raisin tree seed extract preparation under same dose to the protective effect of alcoholic liver injury animal's liver.The results are shown in Table 2.
Table 2 given the test agent on the impact of mouse liver biochemical indicator (n=10, )
Note: with model control group comparison, * P<0.05, * * P<0.01; With the comparison of present composition high dose group, #P<0.05, ##P<0.01
3, histopathologic examination's result
The degree that model control group liver fat changes is significantly higher than blank group (P<0.01); With model control group comparison, kudzu root extract group, the basic, normal, high dosage group of the present composition can significantly be improved the liver fat denaturation degrees (P<0.05 or P<0.01) of alcoholic liver injury animal; Present composition high dose group is significantly higher than kudzu root extract group and raisin tree seed extract group (P<0.05) to the improvement degree of alcoholic liver injury animal's liver steatosis, illustrates that to a certain extent present composition group is better than single kudzu root extract preparation and the single raisin tree seed extract preparation under same dose to the protective effect of alcoholic liver injury.The results are shown in Table 3.
Table 3 given the test agent on the impact of mouse liver fatty change degree (n=10, )
Note: with model control group comparison, * P<0.05, * * P<0.01; With the comparison of present composition high dose group, #P<0.05, ##P<0.01
Conclusion: according to above-mentioned result of the test, according to the Ministry of Public Health, promulgate the middle result judgement of the check of < < health food and value disciplines > > (version in 2003), meet arbitrary condition, can judge that given the test agent has alcoholic liver injury is had to auxiliary protection function: it is positive that liver MDA, reduced form GSH and tri-of TG detect index results; In liver MDA, reduced form GSH and tri-indexs of TG, wantonly two index positives and histopathologic examination's result are positive.The present composition is described, kudzu root extract has that alcoholic liver injury is had to auxiliary protection function.Animal experiment proves, the present composition is better than single kudzu root extract preparation and the single raisin tree seed extract preparation under same dose to alcoholic liver injury auxiliary protection function.
The above is only the preferred embodiment of the present invention, but this should be interpreted as to the scope of the above-mentioned theme of the present invention only limits to above-mentioned example.It should be pointed out that according to foregoing of the present invention, according to ordinary skill knowledge and the customary means of this area, not departing under the above-mentioned basic fundamental thought of the present invention prerequisite, to content of the present invention, can also make modification, replacement or the change of various ways.All technology realizing based on foregoing of the present invention all belong to scope of the present invention.

Claims (10)

1. alcoholic liver injury is there is to a composition for auxiliary protection function, it is characterized in that: mainly take kudzu root extract, raisin tree seed extract, Salvia root P.E, Turmeric P.E, ammonium glycyrrhetate makes oral formulations as raw material; The parts by weight that wherein comprise raw material are: kudzu root extract 57.5-172.5 part, raisin tree seed extract 22.5-67.5 part, Salvia root P.E 35-105 part, Turmeric P.E 18-57 part, ammonium glycyrrhetate 7.5-22.5 part.
2. composition alcoholic liver injury to auxiliary protection function according to claim 1, is characterized in that, mainly adopts the raw material of following weight portion to make:
115 parts of kudzu root extracts, 45 parts of raisin tree seed extracts, 70 parts of Salvia root P.Es, 37.5 parts of Turmeric P.Es, 15 parts of ammonium glycyrrhetates.
3. composition according to claim 1 and 2, is characterized in that, also contains one or more auxiliary materials in microcrystalline cellulose, PVPP, dolomol, dextrin, sucrose, or the conventional pharmaceutical adjunct in other this areas.
4. according to the composition described in claim 1-3 any one, it is characterized in that, described composition is prepared by the following method: kudzu root extract, raisin tree seed extract, Salvia root P.E, Turmeric P.E, ammonium glycyrrhetate are crossed respectively 80 mesh sieves, add auxiliary material, through steps such as batching, mixing, make preparation.
5. according to the composition described in claim 1-3 any one, it is characterized in that described oral formulations is that medically acceptable various formulations comprise capsule, tablet, granule or oral liquid.
6. composition according to claim 5, preferred oral formulations is capsule or tablet.
7. the method for preparing composition described in claim 1-6 any one, is characterized in that, it comprises the steps:
(1), kudzu root extract, raisin tree seed extract, Salvia root P.E, Turmeric P.E, ammonium glycyrrhetate respectively to 80 mesh sieves excessively, standby;
(2), by the kudzu root extract after sieving, raisin tree seed extract, Salvia root P.E, Turmeric P.E, ammonium glycyrrhetate, put in mixer and mix, then add auxiliary material, make oral formulations.
According to the composition described in claim 1-6 any one in the health food for the preparation of auxiliary protection alcoholic liver injury or the application in functional food.
9. according to the composition described in claim 1-6 any one, in preparation, improve the health food of inferior health or the application in functional food.
10. the functional food that contains composition described in claim 1-6 any one.
CN201410356846.9A 2014-07-24 2014-07-24 Composition with auxiliary protection effect on alcoholic liver injury and preparation method thereof Pending CN104172159A (en)

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Cited By (15)

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CN104605058A (en) * 2015-01-01 2015-05-13 张志科 Composition, tea cream and application
CN104667196A (en) * 2015-03-26 2015-06-03 江苏康缘药业股份有限公司 Composition with protection effect against liver with chemical injuries, preparation method and traditional Chinese medicine preparation
CN105410569A (en) * 2015-12-08 2016-03-23 广东省农业科学院蚕业与农产品加工研究所 Preparation method of mulberry drink with protective effect on alcoholic liver injury
CN105816798A (en) * 2016-04-13 2016-08-03 南昌济顺制药有限公司 Liver protecting drug or health food composition
CN105999212A (en) * 2016-05-13 2016-10-12 无限极（中国）有限公司 Composition having alcohol effect dispelling effect and preparation method and application thereof
CN106135891A (en) * 2015-04-15 2016-11-23 吉林省中医药科学院 A kind of health food to alcoholic liver injury with defencive function
CN108652000A (en) * 2018-03-07 2018-10-16 姜学林 Imperial bud liver-protecting and alcoholism-relieving solid articles of a kind of compound thorn and preparation method thereof
CN109965072A (en) * 2019-04-08 2019-07-05 杭州花姐食品有限公司 A kind of pressed candy and the preparation method and application thereof conserving liver
CN111887332A (en) * 2020-08-05 2020-11-06 重庆西大魔芋生物科技有限公司 Konjak chocolate capable of dispelling effects of alcohol, protecting liver and benefiting intestines and preparation method thereof
CN112535230A (en) * 2020-11-12 2021-03-23 浙江英格莱制药有限公司 Herbaceous plant corn peptide vitamin sugar pill and preparation method thereof
CN113694104A (en) * 2021-07-23 2021-11-26 江苏大学 Traditional Chinese medicine composition with protection effect on chemical liver injury and liver regeneration promotion function, preparation method and application thereof
CN114949139A (en) * 2022-05-17 2022-08-30 健码制药（广东）有限公司 Composition for relieving alcoholic liver injury and preparation process thereof
CN115337376A (en) * 2022-08-24 2022-11-15 辽宁泰阳医药科技开发有限公司 Traditional Chinese medicine composition with liver protecting and toxin expelling effects, preparation method and application thereof
CN115487280A (en) * 2022-10-19 2022-12-20 浙江中医药大学 Traditional Chinese medicine composition for relieving alcoholism, protecting liver and promoting liver regeneration, preparation and preparation method thereof
CN115886254A (en) * 2022-10-08 2023-04-04 睿丽生命科技(江苏)有限公司 Food for dispelling effects of alcohol and protecting liver

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CN1883687A (en) * 2006-05-31 2006-12-27 北京药谷传奇医药科技开发有限公司 Liver-benefiting health food made from pure Chinese medicine
CN102342357A (en) * 2010-07-27 2012-02-08 襄樊隆中药业有限责任公司 Formula of antialcoholismic heterosugar tablet and its preparation method
CN102450714A (en) * 2010-10-22 2012-05-16 赵强 Alcoholism-relieving drink and preparation method thereof
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Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104605058A (en) * 2015-01-01 2015-05-13 张志科 Composition, tea cream and application
CN104667196A (en) * 2015-03-26 2015-06-03 江苏康缘药业股份有限公司 Composition with protection effect against liver with chemical injuries, preparation method and traditional Chinese medicine preparation
CN106135891A (en) * 2015-04-15 2016-11-23 吉林省中医药科学院 A kind of health food to alcoholic liver injury with defencive function
CN105410569A (en) * 2015-12-08 2016-03-23 广东省农业科学院蚕业与农产品加工研究所 Preparation method of mulberry drink with protective effect on alcoholic liver injury
CN105410569B (en) * 2015-12-08 2018-07-24 广东省农业科学院蚕业与农产品加工研究所 A kind of preparation method to mulberry beverage of the alcoholic liver injury with protective effect
CN105816798A (en) * 2016-04-13 2016-08-03 南昌济顺制药有限公司 Liver protecting drug or health food composition
CN105999212A (en) * 2016-05-13 2016-10-12 无限极（中国）有限公司 Composition having alcohol effect dispelling effect and preparation method and application thereof
CN108652000A (en) * 2018-03-07 2018-10-16 姜学林 Imperial bud liver-protecting and alcoholism-relieving solid articles of a kind of compound thorn and preparation method thereof
CN109965072A (en) * 2019-04-08 2019-07-05 杭州花姐食品有限公司 A kind of pressed candy and the preparation method and application thereof conserving liver
CN111887332A (en) * 2020-08-05 2020-11-06 重庆西大魔芋生物科技有限公司 Konjak chocolate capable of dispelling effects of alcohol, protecting liver and benefiting intestines and preparation method thereof
CN112535230A (en) * 2020-11-12 2021-03-23 浙江英格莱制药有限公司 Herbaceous plant corn peptide vitamin sugar pill and preparation method thereof
CN113694104A (en) * 2021-07-23 2021-11-26 江苏大学 Traditional Chinese medicine composition with protection effect on chemical liver injury and liver regeneration promotion function, preparation method and application thereof
CN114949139A (en) * 2022-05-17 2022-08-30 健码制药（广东）有限公司 Composition for relieving alcoholic liver injury and preparation process thereof
CN114949139B (en) * 2022-05-17 2023-02-03 健码制药（广东）有限公司 Composition for relieving alcoholic liver injury and preparation process thereof
CN115337376A (en) * 2022-08-24 2022-11-15 辽宁泰阳医药科技开发有限公司 Traditional Chinese medicine composition with liver protecting and toxin expelling effects, preparation method and application thereof
CN115886254A (en) * 2022-10-08 2023-04-04 睿丽生命科技(江苏)有限公司 Food for dispelling effects of alcohol and protecting liver
CN115487280A (en) * 2022-10-19 2022-12-20 浙江中医药大学 Traditional Chinese medicine composition for relieving alcoholism, protecting liver and promoting liver regeneration, preparation and preparation method thereof
CN115487280B (en) * 2022-10-19 2023-12-19 浙江中医药大学 Traditional Chinese medicine composition for dispelling effects of alcohol, protecting liver and promoting liver regeneration as well as preparation and preparation method thereof

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Application publication date: 20141203