CN105362785A - Medicine composition for treating primary hypertension and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine composition for treating primary hypertension and a preparation method thereof. The medicine composition is mainly prepared from vitis flexuosa thumb., pternopetalum nudicaule(de Boiss.) hand.-mazz, botrychium japonicum, a rubus pluribracteatus root, thysanolaena maxima, brassica integrifolia, a paper mulberry root, an artocarpus hypargyreus root, oberonia iridifolia Lindl, piptanthus concolor craib, henon bamboo juvenile leaves, phyllanthus emblica, evening primrose extract, lemon extract and moyeam tea extract. Based on the traditional Chinese medicine theory, the Medicine composition is applied according to symptoms, the formula is precise, reasonable compatibility is achieved, and the Medicine composition has the functions of removing heat to cool blood, encouraging production of body fluid to extinguish thirst, removing toxicity for detumescence, removing liver-fire for improving eyesight, stopping bleeding and reducing blood pressure, can further effectively remove toxicity and relieve mental stress, promotes a normal organism diet, clears away smoke and dispels the effects of alcohol, and is remarkable in treatment effect, mild in medicinal effect and free of side effects. The preparation technology of the Medicine composition for treating primary hypertension is simple, the production cost is low, and good medical value is achieved.

Description

A kind of Chinese medicine composition for the treatment of essential hypertension and preparation method thereof

Technical field

The present invention relates to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of essential hypertension and preparation method thereof.

Background technology

Based on current medical development level and detection methods, can find that the definite cause of disease causing blood pressure to raise is referred to as secondary hypertension, otherwise, the definite cause of disease causing blood pressure to raise can not be found, be then called essential hypertension.In Hypertensive Population, majority is essential hypertension, current medical statistics essential hypertension accounts for 90% ~ 95% of Hypertensive Population, within 2005, American Society of Hypertension proposes, essential hypertension is a cardiovascular syndrome being in continuous state of progress caused by many causes of disease, can cause the change of heart and vascular function and structure.Think that essential hypertension is that some congenital hereditary gene a kind of and many pathogenic supercharging factors and physiological reduce pressure factor interaction and the multi-factor disease caused at present, these factors mainly comprise: the low potassium meals of hereditary, high sodium, Overweight and obesity, excessive consumption of alcohol, long-term spiritual hypertonicity etc., the life style of therefore keeping fit contributes to preventing and delay hypertensive generation.Sodium salt can significantly raising blood pressure and hypertensive onset risk, and potassium salt then can resist the effect of sodium salt raising blood pressure; Overweight and obesity is one of major reason causing blood pressure to raise, and take abdominal fat accumulation as the risk that the central obesity of typical characteristic also can increase the cardiovascular such as hypertension and metabolic disease further, the suitable body weight reducing rising, reduces body fat content, can significantly reduce blood pressure; Smoking can cause blood vessel endothelium to damage, and significantly increases the risk that atherosclerosis occurs hyperpietic; Long-term heavy drinking can cause blood pressure to raise, and restriction drinking amount then significantly can reduce hypertension; Regular physical training then can produce important therapeutical effect, can reduce blood pressure, improve carbohydrate metabolism etc.; Psychology or stress cause psychological stress, i.e. the reaction made psychology and the stimulation of physiologic factor in environment of human body.

Treatment essential hypertension also start with from many aspects come comprehensive adjustment human body balance, blood pressure is made to return to normal condition, conventional antihypertensive drugs comprises calcium channel blocker, angiotensin converting enzyme inhibitor, angiotensin receptor blocker, diuretic and beta-blocker five class, and the fixed mixing ratio compound preparation be made up of said medicine.In addition, alpha-blocking agent or other kind of hypotensor also can be applicable to some Hypertensive Population sometimes.Calcium channel blocker, ACEI, ARB, diuretic and beta-blocker and low dosage immobilised compound preparation thereof, all can be used as initial medication or the long term maintenance medication of Treatment of Hypertension, single medicine or therapeutic alliance.But more than treatment also just controls blood pressure targetedly, the object fundamentally regulating human body function to reduce blood pressure can not be reached.

Summary of the invention

For making up the deficiencies in the prior art, the invention provides a kind of good effect, instant effect, having no side effect, the Chinese medicine composition for the treatment of essential hypertension easy to use.

Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine composition of essential hypertension.

For achieving the above object, technical scheme of the present invention is: a kind of Chinese medicine composition for the treatment of essential hypertension, component meter by weight, mainly be made up of following raw material: Pueraria lobota Bud root 60 ~ 90 parts, medicine root of Herba Apii graveolentis 55 ~ 80 parts, Botrychium japonicum (Prantl) underw 52 ~ 78 parts, Radix Rubi Setchuenensis 42 ~ 65 parts, Herba Thysanolaenae maximae 40 ~ 58 parts, bitter 38 ~ 56 parts, mustard, Radix broussonetiae 38 ~ 55 parts, Bai Guimu root 35 ~ 52 parts, Herba Oberoniae iridifoliae 36 ~ 48 parts, Semen piptanthi concoloris 34 ~ 46 parts, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle 30 ~ 45 parts, Fructus Phyllanthi 30 ~ 43 parts, Radix Oenotherae erythrosepalae extract 4.2 ~ 5.6 parts, citron extract 3.8 ~ 5.4 parts, Ampelopsis grossedentata extrat 2.8 ~ 4.6 parts.

Further, described a kind of Chinese medicine composition for the treatment of essential hypertension, component meter by weight, is mainly made up of following raw material: Pueraria lobota Bud root 75 parts, medicine root of Herba Apii graveolentis 68 parts, Botrychium japonicum (Prantl) underw 65 parts, Radix Rubi Setchuenensis 54 parts, Herba Thysanolaenae maximae 49 parts, 47 parts, bitter mustard, Radix broussonetiae 46 parts, Bai Guimu root 44 parts, Herba Oberoniae iridifoliae 42 parts, Semen piptanthi concoloris 40 parts, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle 38 parts, Fructus Phyllanthi 37 parts, Radix Oenotherae erythrosepalae extract 4.9 parts, citron extract 4.6 parts, Ampelopsis grossedentata extrat 3.7 parts.

Further, described Radix Oenotherae erythrosepalae extract is Radix Oenotherae erythrosepalae oil, its extracting method is: after evening primrose seed wash clean, be placed in oven drying, baking oven set temperature 60 DEG C, make its moisture lower than 5%, then ultra micro comminution by gas stream is carried out, cross 100 ~ 120 mesh sieves, obtain evening primrose seed powder, add the distilled water of 10 times amount, add 0.08 times amount mixed enzyme again, enzymolysis 2 ~ 5h under the condition of vacuum-0.03 ~-0.05MPa and temperature 50 ~ 60 DEG C, by the enzymolysis solution microwave radiation exaraction 45min under the condition of temperature 80 ~ 90 DEG C obtained, with Rotary Evaporators concentrating under reduced pressure, organic solvent is removed, namely Radix Oenotherae erythrosepalae oil is obtained.Contain in Radix Oenotherae erythrosepalae oil: r-linoleic acid, magnesium, zinc, the effective ingredient such as copper, injection Vitamin B_6, B6, B5, be the extremely polynary undersaturated essential fatty acid of one, the endogenous factor of inflammatory that Oleum Arachidis hypogaeae semen tetraenoic acid produces in vivo can be replaced in the process of metabolism in vivo, as prostaglandin, leukotrienes and the Prothrombin causing Coagulation test, except anti-inflammatory effect, Radix Oenotherae erythrosepalae oil also has the effect reducing Coagulation test, antithrombotic.

Further, described mixed enzyme to be fully uniformly mixed according to the weight ratio of 4:1:2 by chitinase, cellulase, papain to obtain, it carries out enzymolysis to organic substances such as cellulose, starch, protein in Radix Oenotherae erythrosepalae and the mixed solution of water respectively, thus isolates the active substance containing Radix Oenotherae erythrosepalae oil fast.

Further, described citron extract preparation method is: cleaned by lemon fruit, is ground into 20 ~ 40 orders with pulverizer, carries out supersound extraction with ethanol, solid-liquid ratio is 1:(2 ~ 6), the mass concentration of ethanol is 60 ~ 80%, and ultrasonic power is 30 ~ 40KHz, and temperature is 55 DEG C, extraction time is 30 minutes, be separated with macroporous adsorption resin chromatography, dry, the brown color fine powder obtained is citron extract again.Citron extract has and promotes the production of body fluid, and quenches the thirst, drives away summer heat, antiabortive, pharyngalgia xerostomia, gastral cavilty flatulence, hypertension, myocardial infarction, effect of anorexia.

Further, described Ampelopsis grossedentata extrat preparation method is: by Ampelopsis grossedentata crushed after being dried, cross 20 ~ 30 mesh sieves, obtain Ampelopsis grossedentata coarse powder, to add in Ampelopsis grossedentata coarse powder 15 times of quality containing the protectant aqueous solution of flavone, in aqueous solution, the protectant mass percent of flavone is 0.05%, the pH value of aqueous solution is 3, filter after 85 DEG C of heating 30min leave standstill, obtain Ampelopsis grossedentata water clear liquid, Ampelopsis grossedentata Aqueous extracts clear liquid is heated, vacuum concentration, be cooled to 5 DEG C, crystallization, to the deionized water drip washing adding 5 times of quality in crystal, centrifuge dehydration, microwave drying, obtain Ampelopsis grossedentata extrat.

Treat a preparation method for the Chinese medicine composition of essential hypertension, comprise the following steps:

Step one: after evening primrose seed wash clean, be placed in oven drying, baking oven set temperature 60 DEG C, make its moisture lower than 5%, then ultra micro comminution by gas stream is carried out, cross 100 ~ 120 mesh sieves, obtain evening primrose seed powder, add the distilled water of 10 times amount, add 0.08 times amount mixed enzyme again, described mixed enzyme is by chitinase, cellulase, papain is fully uniformly mixed according to the weight ratio of 4:1:2 and obtains, it is respectively to cellulose in Radix Oenotherae erythrosepalae and the mixed solution of water, starch, the organic substances such as protein carry out enzymolysis, thus the active substance isolated fast containing Radix Oenotherae erythrosepalae oil, enzymolysis 2 ~ 5h under the condition of vacuum-0.03 ~-0.05MPa and temperature 50 ~ 60 DEG C, by the enzymolysis solution microwave radiation exaraction 45min under the condition of temperature 80 ~ 90 DEG C obtained, with Rotary Evaporators concentrating under reduced pressure, organic solvent is removed, namely Radix Oenotherae erythrosepalae oil is obtained, contain in Radix Oenotherae erythrosepalae oil: r-linoleic acid, magnesium, zinc, copper, vitamin C, E, B6, the effective ingredient such as B5, it is the extremely polynary undersaturated essential fatty acid of one, the endogenous factor of inflammatory that Oleum Arachidis hypogaeae semen tetraenoic acid produces in vivo can be replaced in the process of metabolism in vivo, as prostaglandin, the Prothrombin of leukotrienes and initiation Coagulation test, except anti-inflammatory effect, Radix Oenotherae erythrosepalae oil also has reduction Coagulation test, the effect of antithrombotic,

Step 2: lemon fruit is cleaned, be ground into 20 ~ 40 orders with pulverizer, carry out supersound extraction with ethanol, solid-liquid ratio is 1:(2 ~ 6), the mass concentration of ethanol is 60 ~ 80%, ultrasonic power is 30 ~ 40KHz, and temperature is 55 DEG C, and extraction time is 30 minutes, be separated with macroporous adsorption resin chromatography again, drying, the brown color fine powder obtained is citron extract, and citron extract has and promotes the production of body fluid, quench the thirst, drive away summer heat, antiabortive, pharyngalgia xerostomia, gastral cavilty flatulence, hypertension, myocardial infarction, effect of anorexia;

Step 3: by Ampelopsis grossedentata crushed after being dried, cross 20 ~ 30 mesh sieves, obtain Ampelopsis grossedentata coarse powder, to add in Ampelopsis grossedentata coarse powder 15 times of quality containing the protectant aqueous solution of flavone, in aqueous solution, the protectant mass percent of flavone is 0.05%, the pH value of aqueous solution is filter after 3,85 DEG C of heating 30min leave standstill, and obtains Ampelopsis grossedentata water clear liquid, Ampelopsis grossedentata Aqueous extracts clear liquid is heated, vacuum concentration, is cooled to 5 DEG C, crystallization, to the deionized water drip washing adding 5 times of quality in crystal, centrifuge dehydration, microwave drying, obtains Ampelopsis grossedentata extrat;

Step 4: take Pueraria lobota Bud root by described components by weight percent, medicine root of Herba Apii graveolentis, Botrychium japonicum (Prantl) underw, Radix Rubi Setchuenensis, Radix broussonetiae, Bai Guimu root, Fructus Phyllanthi, all medical materials are cut into the thin slice of 2mm, be placed in oven for drying, baking oven set temperature 60 DEG C, make Chinese medicine tablet moisture lower than 5%, take the Semen piptanthi concoloris seed of described components by weight percent, crushed after being dried, cross 50 mesh sieves, obtain Semen piptanthi concoloris coarse powder, by Chinese medicine tablet and the mixing of Semen piptanthi concoloris coarse powder, add the pure water of 8 ~ 10 times amount of mixing medical material gross weight, soak 8 ~ 12h, use special marmite, fine coal ash quantity after described special marmite refers to the calcining added in clay is 1.2 times that common marmite is fired, firing temperature is higher than common marmite 100 DEG C, the raising of fine coal ash quantity can increase the activated carbon constituents in marmite, thus a large amount of negative oxygen ion can be formed make to have strong physical absorption and chemical adsorption capacity, therefore can except the heavy metal ion in anhydrating, stink, rust etc., and effectively can stop the loss of effective ingredient in medical material, improving firing temperature can make the heat-resisting quantity of marmite improve, can more be uniformly dissolved from making medicinal ingredient, intense fire heated and boiled, slow fire boiling is extracted, decoct 2-3 hour, again add the pure water of 6 ~ 8 times amount, intense fire heated and boiled, slow fire boiling is extracted, decoct 1 ~ 2 hour, merge the extracting solution of twice,

Step 5: take fresh Herba Thysanolaenae maximae by described components by weight percent, bitter mustard, Herba Oberoniae iridifoliae, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle smash to pieces, and the mass concentration adding 5 times amount is 75% alcoholic solution, blender is used to stir 30min, the supernatant is extracted after leaving standstill 12h, carry out 85 ~ 95 DEG C of microwave sterilizating, sterilization time 90 ~ 120s, reclaims the ethanol in filtrate and concentrates, obtained mixture extractum;

Step 6: the mixture extractum mix homogeneously that extracting solution step 4 obtained and step 5 obtain, 3h is left standstill after stirring, then centrifuge 5000 ~ 6000r/min centrifugal sediment is used, filter, add Radix Oenotherae erythrosepalae extract, citron extract, the Ampelopsis grossedentata extrat of described components by weight percent more respectively, the Chinese medicine composition of the essential hypertension that namely obtains medical treatment.

Further, the preparation method that a kind of Chinese medicine composition for the treatment of essential hypertension makes capsule comprises the following steps:

Step one: after evening primrose seed wash clean, be placed in oven drying, baking oven set temperature 60 DEG C, make its moisture lower than 5%, then ultra micro comminution by gas stream is carried out, cross 100 ~ 120 mesh sieves, obtain evening primrose seed powder, add the distilled water of 10 times amount, add 0.08 times amount mixed enzyme again, described mixed enzyme is by chitinase, cellulase, papain is fully uniformly mixed according to the weight ratio of 4:1:2 and obtains, it is respectively to cellulose in Radix Oenotherae erythrosepalae and the mixed solution of water, starch, the organic substances such as protein carry out enzymolysis, thus isolate active substance containing Radix Oenotherae erythrosepalae oil enzymolysis 2 ~ 5h under the condition of vacuum-0.03 ~-0.05MPa and temperature 50 ~ 60 DEG C fast, by the enzymolysis solution microwave radiation exaraction 45min under the condition of temperature 80 ~ 90 DEG C obtained, with Rotary Evaporators concentrating under reduced pressure, organic solvent is removed, namely Radix Oenotherae erythrosepalae oil is obtained, contain in Radix Oenotherae erythrosepalae oil: r-linoleic acid, magnesium, zinc, copper, vitamin C, E, B6, the effective ingredient such as B5, it is the extremely polynary undersaturated essential fatty acid of one, the endogenous factor of inflammatory that Oleum Arachidis hypogaeae semen tetraenoic acid produces in vivo can be replaced in the process of metabolism in vivo, as prostaglandin, the Prothrombin of leukotrienes and initiation Coagulation test, except anti-inflammatory effect, Radix Oenotherae erythrosepalae oil also has reduction Coagulation test, the effect of antithrombotic,

Step 2: lemon fruit is cleaned, be ground into 20 ~ 40 orders with pulverizer, carry out supersound extraction with ethanol, solid-liquid ratio is 1:(2 ~ 6), the mass concentration of ethanol is 60 ~ 80%, ultrasonic power is 30 ~ 40KHz, and temperature is 55 DEG C, and extraction time is 30 minutes, be separated with macroporous adsorption resin chromatography again, drying, the brown color fine powder obtained is citron extract, and citron extract has and promotes the production of body fluid, quench the thirst, drive away summer heat, antiabortive, pharyngalgia xerostomia, gastral cavilty flatulence, hypertension, myocardial infarction, effect of anorexia;

Step 3: by Ampelopsis grossedentata crushed after being dried, cross 20 ~ 30 mesh sieves, obtain Ampelopsis grossedentata coarse powder, to add in Ampelopsis grossedentata coarse powder 15 times of quality containing the protectant aqueous solution of flavone, in aqueous solution, the protectant mass percent of flavone is 0.05%, the pH value of aqueous solution is filter after 3,85 DEG C of heating 30min leave standstill, and obtains Ampelopsis grossedentata water clear liquid, Ampelopsis grossedentata Aqueous extracts clear liquid is heated, vacuum concentration, is cooled to 5 DEG C, crystallization, to the deionized water drip washing adding 5 times of quality in crystal, centrifuge dehydration, microwave drying, obtains Ampelopsis grossedentata extrat;

Step 4: take Pueraria lobota Bud root by described components by weight percent, medicine root of Herba Apii graveolentis, Botrychium japonicum (Prantl) underw, Radix Rubi Setchuenensis, Radix broussonetiae, Bai Guimu root, Fructus Phyllanthi, all medical materials are cut into the thin slice of 2mm, be placed in oven for drying, baking oven set temperature 60 DEG C, make Chinese medicine tablet moisture lower than 5%, take the Semen piptanthi concoloris seed of described components by weight percent, crushed after being dried, cross 50 mesh sieves, obtain Semen piptanthi concoloris coarse powder, by Chinese medicine tablet and the mixing of Semen piptanthi concoloris coarse powder, add the pure water of 8 ~ 10 times amount of mixing medical material gross weight, soak 8 ~ 12h, use special marmite, fine coal ash quantity after described special marmite refers to the calcining added in clay is 1.2 times that common marmite is fired, firing temperature is higher than common marmite 100 DEG C, the raising of fine coal ash quantity can increase the activated carbon constituents in marmite, thus a large amount of negative oxygen ion can be formed make to have strong physical absorption and chemical adsorption capacity, therefore can except the heavy metal ion in anhydrating, stink, rust etc., and effectively can stop the loss of effective ingredient in medical material, improving firing temperature can make the heat-resisting quantity of marmite improve, can more be uniformly dissolved from making medicinal ingredient, intense fire heated and boiled, slow fire boiling is extracted, decoct 2-3 hour, again add the pure water of 6 ~ 8 times amount, intense fire heated and boiled, slow fire boiling is extracted, decoct 1 ~ 2 hour, merge the extracting solution of twice,

Step 5: take fresh Herba Thysanolaenae maximae by described components by weight percent, bitter mustard, Herba Oberoniae iridifoliae, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle smash to pieces, and the mass concentration adding 5 times amount is 75% alcoholic solution, blender is used to stir 30min, the supernatant is extracted after leaving standstill 12h, carry out 85 ~ 95 DEG C of microwave sterilizating, sterilization time 90 ~ 120s, reclaims the ethanol in filtrate and concentrates, obtained mixture extractum;

Step 6: the mixture extractum mix homogeneously that extracting solution step 4 obtained and step 5 obtain, 3h is left standstill after stirring, then centrifuge 5000 ~ 6000r/min centrifugal sediment is used, filter, add Radix Oenotherae erythrosepalae extract, citron extract, the Ampelopsis grossedentata extrat of described components by weight percent more respectively, the Chinese medicine composition of the essential hypertension that namely obtains medical treatment;

Step 7: add lactose 6.8 parts, micropowder silica gel 5.2 parts, polyoxyethylene sorbitan monoleate 4.6 parts by following components by weight percent in the Chinese medicine composition that step 6 is obtained, capsule is made by corresponding Technology, described lactose Main Function is absorption dispersant, described micropowder silica gel Main Function is raising agent, and described polyoxyethylene sorbitan monoleate Main Function is wetting agent.

The pharmacologically active of each raw material of Chinese medicine of the present invention is as follows:

Pueraria lobota Bud root: dampness removing jaundice eliminating, promoting blood circulation to remove obstruction in the collateral, removing toxic substances and promoting subsidence of swelling, main icterohepatitis, rheumatic arthralgia, traumatic injury, carbuncle;

Medicine root of Herba Apii graveolentis: promoting blood circulation to remove obstruction in the collateral, removing toxic substances, main impairment caused by overstrain, sore;

Botrychium japonicum (Prantl) underw: liver heat removing and eyesight improving, detumescence of reducing phlegm, main conjunctival congestion and swelling pain, infantile hyperpyrexia is twitched, cough, spits blood, scrofula, carbuncle skin ulcer;

Radix Rubi Setchuenensis: removing heat from blood, invigorates blood circulation, and controls over-strained hemoptysis, hemoptysis, menoxenia, dysentery, scrofula, fracture;

Herba Thysanolaenae maximae: heat-clearing and toxic substances removing, promoting the production of body fluid to quench thirst, cures mainly malaria;

Bitter mustard: clearing away heat and cooling blood, diuresis removing food stagnancy, main high heat, dysuria, stops in stagnant, abdominal distention;

Radix broussonetiae: heat clearing away, removing heat from blood, dampness removing, eliminates the phlegm, and controls cough and spits blood, edema, metrorrhagia, traumatic injury;

Bai Guimu root: expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral, main air pain of dampness syndrome, headache, paturient's hypogalactia;

Herba Oberoniae iridifoliae: regulate the flow of vital energy and help digestion, clearing away heat and promoting diuresis, cough-relieving pain relieving, for dyspepsia, stomachache, enteritis, urinary tract infection, cough, bronchitis, asthma, traumatic injury, fracture, venom;

Semen piptanthi concoloris: liver heat removing and eyesight improving, diuretic, intestine moistening, controls headache due to pathogenic wind-heat, acute conjunctivitis, hypertension, chronic constipation;

Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle: clear away heart-fire relieving restlessness, relieves heat and thirst;

Fructus Phyllanthi: clearing away heat and cooling blood, promoting digestion and invigorating the stomach, cough-relieving of promoting the production of body fluid.For heat in blood blood stasis, dyspepsia, abdominal distention, cough, laryngalgia, xerostomia;

Radix Oenotherae erythrosepalae oil: promoting blood circulation to remove obstruction in the collateral, endogenous wind stopping suppressing the hyperactive liver, detumescence sore, main obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, stirring-up of pathogenic wind in the interior resulting from deficiency, children's moves more, wind dampness rheumatic anesthesia pain, and stomachache is had loose bowels, dysmenorrhea, oral-anal-genital ulcer syndrome, skin infection, eczema;

Citron extract: preventing phlegm from forming and stopping coughing, stomach invigorating of promoting the production of body fluid, for bronchitis, pertussis, inappetence, Vitamin C deficiency disease, heatstroke excessive thirst;

Ampelopsis grossedentata extrat: clearing away heat-damp and promoting diuresis, suppressing the hyperactive liver blood pressure lowering, promoting blood circulation to remove obstruction in the collateral, main dysentery, has loose bowels, and urine leaching pain, hypertension, dizzy order is swollen, traumatic injury.

Compared with prior art, beneficial effect of the present invention is embodied in: by selected multiple Chinese herbal medicine and Chinese herbal medicine extract, effectively can play clearing away heat and cooling blood, promoting the production of body fluid to quench thirst, removing toxic substances and promoting subsidence of swelling, liver heat removing and eyesight improving, effect of hemostasis blood pressure lowering, can also toxin expelling, stress of releiving, promote that body diet is normal, clear cigarette relieves the effect of alcohol, evident in efficacy, and drug effect is gentle, have no side effect, for treatment essential hypertension evident in efficacy, short treating period, instant effect, easy to use, through clinical verification without any toxic and side effects, the relieved use of this patient.

Detailed description of the invention

Below in conjunction with detailed description of the invention, the present invention is described in more detail:

Embodiment 1: a kind of Chinese medicine composition for the treatment of essential hypertension, component meter by weight, is mainly made up of following raw material: Pueraria lobota Bud root 60 parts, medicine root of Herba Apii graveolentis 55 parts, Botrychium japonicum (Prantl) underw 52 parts, Radix Rubi Setchuenensis 42 parts, Herba Thysanolaenae maximae 40 parts, 38 parts, bitter mustard, Radix broussonetiae 38 parts, Bai Guimu root 35 parts, Herba Oberoniae iridifoliae 36 parts, Semen piptanthi concoloris 34 parts, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle 30 parts, Fructus Phyllanthi 30 parts, Radix Oenotherae erythrosepalae extract 4.2 parts, citron extract 3.8 parts, Ampelopsis grossedentata extrat 2.8 parts.

The preparation method that a kind of Chinese medicine composition for the treatment of essential hypertension makes capsule comprises the following steps:

Step one: after evening primrose seed wash clean, be placed in oven drying, baking oven set temperature 60 DEG C, make its moisture lower than 5%, then ultra micro comminution by gas stream is carried out, cross 100 mesh sieves, obtain evening primrose seed powder, add the distilled water of 10 times amount, add 0.08 times amount mixed enzyme again, described mixed enzyme is by chitinase, cellulase, papain is fully uniformly mixed according to the weight ratio of 4:1:2 and obtains, it is respectively to cellulose in Radix Oenotherae erythrosepalae and the mixed solution of water, starch, the organic substances such as protein carry out enzymolysis, thus isolate active substance containing Radix Oenotherae erythrosepalae oil enzymolysis 2h under the condition of vacuum-0.03MPa and temperature 50 C fast, by the enzymolysis solution microwave radiation exaraction 45min under the condition of temperature 80 DEG C obtained, with Rotary Evaporators concentrating under reduced pressure, organic solvent is removed, namely Radix Oenotherae erythrosepalae oil is obtained, contain in Radix Oenotherae erythrosepalae oil: r-linoleic acid, magnesium, zinc, copper, vitamin C, E, B6, the effective ingredient such as B5, it is the extremely polynary undersaturated essential fatty acid of one, the endogenous factor of inflammatory that Oleum Arachidis hypogaeae semen tetraenoic acid produces in vivo can be replaced in the process of metabolism in vivo, as prostaglandin, the Prothrombin of leukotrienes and initiation Coagulation test, except anti-inflammatory effect, Radix Oenotherae erythrosepalae oil also has reduction Coagulation test, the effect of antithrombotic,

Step 2: cleaned by lemon fruit, is ground into 20 orders with pulverizer, carries out supersound extraction with ethanol, and solid-liquid ratio is 1:6, the mass concentration of ethanol is 60%, and ultrasonic power is 30KHz, and temperature is 55 DEG C, and extraction time is 30 minutes, be separated with macroporous adsorption resin chromatography, dry, the brown color fine powder obtained is citron extract again, citron extract has and promotes the production of body fluid, and quenches the thirst, drives away summer heat, antiabortive, pharyngalgia xerostomia, gastral cavilty flatulence, hypertension, myocardial infarction, effect of anorexia;

Step 3: by Ampelopsis grossedentata crushed after being dried, cross 20 mesh sieves, obtain Ampelopsis grossedentata coarse powder, to add in Ampelopsis grossedentata coarse powder 15 times of quality containing the protectant aqueous solution of flavone, in aqueous solution, the protectant mass percent of flavone is 0.05%, the pH value of aqueous solution is filter after 3,85 DEG C of heating 30min leave standstill, and obtains Ampelopsis grossedentata water clear liquid, Ampelopsis grossedentata Aqueous extracts clear liquid is heated, vacuum concentration, is cooled to 5 DEG C, crystallization, to the deionized water drip washing adding 5 times of quality in crystal, centrifuge dehydration, microwave drying, obtains Ampelopsis grossedentata extrat;

Step 4: take Pueraria lobota Bud root by described components by weight percent, medicine root of Herba Apii graveolentis, Botrychium japonicum (Prantl) underw, Radix Rubi Setchuenensis, Radix broussonetiae, Bai Guimu root, Fructus Phyllanthi, all medical materials are cut into the thin slice of 2mm, be placed in oven for drying, baking oven set temperature 60 DEG C, make Chinese medicine tablet moisture lower than 5%, take the Semen piptanthi concoloris seed of described components by weight percent, crushed after being dried, cross 50 mesh sieves, obtain Semen piptanthi concoloris coarse powder, by Chinese medicine tablet and the mixing of Semen piptanthi concoloris coarse powder, add the pure water of 8 times amount of mixing medical material gross weight, soak 8h, use special marmite, fine coal ash quantity after described special marmite refers to the calcining added in clay is 1.2 times that common marmite is fired, firing temperature is higher than common marmite 100 DEG C, the raising of fine coal ash quantity can increase the activated carbon constituents in marmite, thus a large amount of negative oxygen ion can be formed make to have strong physical absorption and chemical adsorption capacity, therefore can except the heavy metal ion in anhydrating, stink, rust etc., and effectively can stop the loss of effective ingredient in medical material, improving firing temperature can make the heat-resisting quantity of marmite improve, can more be uniformly dissolved from making medicinal ingredient, intense fire heated and boiled, slow fire boiling is extracted, decoct 2 hours, again add the pure water of 6 times amount, intense fire heated and boiled, slow fire boiling is extracted, decoct 1 hour, merge the extracting solution of twice,

Step 5: take fresh Herba Thysanolaenae maximae by described components by weight percent, bitter mustard, Herba Oberoniae iridifoliae, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle smash to pieces, and the mass concentration adding 5 times amount is 75% alcoholic solution, blender is used to stir 30min, the supernatant is extracted after leaving standstill 12h, carry out 85 DEG C of microwave sterilizating, sterilization time 90s, reclaims the ethanol in filtrate and concentrates, obtained mixture extractum;

Step 6: the mixture extractum mix homogeneously that extracting solution step 4 obtained and step 5 obtain, 3h is left standstill after stirring, then centrifuge 5000r/min centrifugal sediment is used, filter, add Radix Oenotherae erythrosepalae extract, citron extract, the Ampelopsis grossedentata extrat of described components by weight percent more respectively, the Chinese medicine composition of the essential hypertension that namely obtains medical treatment;

Step 7: add lactose 6.8 parts, micropowder silica gel 5.2 parts, polyoxyethylene sorbitan monoleate 4.6 parts by following components by weight percent in the Chinese medicine composition that step 6 is obtained, capsule is made by corresponding Technology, described lactose Main Function is absorption dispersant, described micropowder silica gel Main Function is raising agent, and described polyoxyethylene sorbitan monoleate Main Function is wetting agent.

Embodiment 2: a kind of Chinese medicine composition for the treatment of essential hypertension, component meter by weight, is mainly made up of following raw material: Pueraria lobota Bud root 75 parts, medicine root of Herba Apii graveolentis 68 parts, Botrychium japonicum (Prantl) underw 65 parts, Radix Rubi Setchuenensis 54 parts, Herba Thysanolaenae maximae 49 parts, 47 parts, bitter mustard, Radix broussonetiae 46 parts, Bai Guimu root 44 parts, Herba Oberoniae iridifoliae 42 parts, Semen piptanthi concoloris 40 parts, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle 38 parts, Fructus Phyllanthi 37 parts, Radix Oenotherae erythrosepalae extract 4.9 parts, citron extract 4.6 parts, Ampelopsis grossedentata extrat 3.7 parts.

The preparation method that a kind of Chinese medicine composition for the treatment of essential hypertension makes capsule comprises the following steps:

Step one: after evening primrose seed wash clean, be placed in oven drying, baking oven set temperature 60 DEG C, make its moisture lower than 5%, then ultra micro comminution by gas stream is carried out, cross 110 mesh sieves, obtain evening primrose seed powder, add the distilled water of 10 times amount, add 0.08 times amount mixed enzyme again, described mixed enzyme is by chitinase, cellulase, papain is fully uniformly mixed according to the weight ratio of 4:1:2 and obtains, it is respectively to cellulose in Radix Oenotherae erythrosepalae and the mixed solution of water, starch, the organic substances such as protein carry out enzymolysis, thus isolate active substance containing Radix Oenotherae erythrosepalae oil enzymolysis 3.5h under the condition of vacuum-0.04MPa and temperature 55 DEG C fast, by the enzymolysis solution microwave radiation exaraction 45min under the condition of temperature 85 DEG C obtained, with Rotary Evaporators concentrating under reduced pressure, organic solvent is removed, namely Radix Oenotherae erythrosepalae oil is obtained, contain in Radix Oenotherae erythrosepalae oil: r-linoleic acid, magnesium, zinc, copper, vitamin C, E, B6, the effective ingredient such as B5, it is the extremely polynary undersaturated essential fatty acid of one, the endogenous factor of inflammatory that Oleum Arachidis hypogaeae semen tetraenoic acid produces in vivo can be replaced in the process of metabolism in vivo, as prostaglandin, the Prothrombin of leukotrienes and initiation Coagulation test, except anti-inflammatory effect, Radix Oenotherae erythrosepalae oil also has reduction Coagulation test, the effect of antithrombotic,

Step 2: cleaned by lemon fruit, is ground into 30 orders with pulverizer, carries out supersound extraction with ethanol, and solid-liquid ratio is 1:4, the mass concentration of ethanol is 70%, and ultrasonic power is 35KHz, and temperature is 55 DEG C, and extraction time is 30 minutes, be separated with macroporous adsorption resin chromatography, dry, the brown color fine powder obtained is citron extract again, citron extract has and promotes the production of body fluid, and quenches the thirst, drives away summer heat, antiabortive, pharyngalgia xerostomia, gastral cavilty flatulence, hypertension, myocardial infarction, effect of anorexia;

Step 3: by Ampelopsis grossedentata crushed after being dried, cross 25 mesh sieves, obtain Ampelopsis grossedentata coarse powder, to add in Ampelopsis grossedentata coarse powder 15 times of quality containing the protectant aqueous solution of flavone, in aqueous solution, the protectant mass percent of flavone is 0.05%, the pH value of aqueous solution is filter after 3,85 DEG C of heating 30min leave standstill, and obtains Ampelopsis grossedentata water clear liquid, Ampelopsis grossedentata Aqueous extracts clear liquid is heated, vacuum concentration, is cooled to 5 DEG C, crystallization, to the deionized water drip washing adding 5 times of quality in crystal, centrifuge dehydration, microwave drying, obtains Ampelopsis grossedentata extrat;

Step 4: take Pueraria lobota Bud root by described components by weight percent, medicine root of Herba Apii graveolentis, Botrychium japonicum (Prantl) underw, Radix Rubi Setchuenensis, Radix broussonetiae, Bai Guimu root, Fructus Phyllanthi, all medical materials are cut into the thin slice of 2mm, be placed in oven for drying, baking oven set temperature 60 DEG C, make Chinese medicine tablet moisture lower than 5%, take the Semen piptanthi concoloris seed of described components by weight percent, crushed after being dried, cross 50 mesh sieves, obtain Semen piptanthi concoloris coarse powder, by Chinese medicine tablet and the mixing of Semen piptanthi concoloris coarse powder, add the pure water of 9 times amount of mixing medical material gross weight, soak 10h, use special marmite, fine coal ash quantity after described special marmite refers to the calcining added in clay is 1.2 times that common marmite is fired, firing temperature is higher than common marmite 100 DEG C, the raising of fine coal ash quantity can increase the activated carbon constituents in marmite, thus a large amount of negative oxygen ion can be formed make to have strong physical absorption and chemical adsorption capacity, therefore can except the heavy metal ion in anhydrating, stink, rust etc., and effectively can stop the loss of effective ingredient in medical material, improving firing temperature can make the heat-resisting quantity of marmite improve, can more be uniformly dissolved from making medicinal ingredient, intense fire heated and boiled, slow fire boiling is extracted, decoct 2.5 hours, again add the pure water of 7 times amount, intense fire heated and boiled, slow fire boiling is extracted, decoct 1.5 hours, merge the extracting solution of twice,

Step 5: take fresh Herba Thysanolaenae maximae by described components by weight percent, bitter mustard, Herba Oberoniae iridifoliae, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle smash to pieces, and the mass concentration adding 5 times amount is 75% alcoholic solution, blender is used to stir 30min, the supernatant is extracted after leaving standstill 12h, carry out 90 DEG C of microwave sterilizating, sterilization time 105s, reclaims the ethanol in filtrate and concentrates, obtained mixture extractum;

Step 6: the mixture extractum mix homogeneously that extracting solution step 4 obtained and step 5 obtain, 3h is left standstill after stirring, then centrifuge 5500r/min centrifugal sediment is used, filter, add Radix Oenotherae erythrosepalae extract, citron extract, the Ampelopsis grossedentata extrat of described components by weight percent more respectively, the Chinese medicine composition of the essential hypertension that namely obtains medical treatment;

Step 7: add lactose 6.8 parts, micropowder silica gel 5.2 parts, polyoxyethylene sorbitan monoleate 4.6 parts by following components by weight percent in the Chinese medicine composition that step 6 is obtained, capsule is made by corresponding Technology, described lactose Main Function is absorption dispersant, described micropowder silica gel Main Function is raising agent, and described polyoxyethylene sorbitan monoleate Main Function is wetting agent.

Embodiment 3: a kind of Chinese medicine composition for the treatment of essential hypertension, component meter by weight, is mainly made up of following raw material: Pueraria lobota Bud root 90 parts, medicine root of Herba Apii graveolentis 80 parts, Botrychium japonicum (Prantl) underw 78 parts, Radix Rubi Setchuenensis 65 parts, Herba Thysanolaenae maximae 58 parts, 56 parts, bitter mustard, Radix broussonetiae 55 parts, Bai Guimu root 52 parts, Herba Oberoniae iridifoliae 48 parts, Semen piptanthi concoloris 46 parts, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle 45 parts, Fructus Phyllanthi 43 parts, Radix Oenotherae erythrosepalae extract 5.6 parts, citron extract 5.4 parts, Ampelopsis grossedentata extrat 4.6 parts.

The preparation method that a kind of Chinese medicine composition for the treatment of essential hypertension makes capsule comprises the following steps:

Step one: after evening primrose seed wash clean, be placed in oven drying, baking oven set temperature 60 DEG C, make its moisture lower than 5%, then ultra micro comminution by gas stream is carried out, cross 120 mesh sieves, obtain evening primrose seed powder, add the distilled water of 10 times amount, add 0.08 times amount mixed enzyme again, described mixed enzyme is by chitinase, cellulase, papain is fully uniformly mixed according to the weight ratio of 4:1:2 and obtains, it is respectively to cellulose in Radix Oenotherae erythrosepalae and the mixed solution of water, starch, the organic substances such as protein carry out enzymolysis, thus isolate active substance containing Radix Oenotherae erythrosepalae oil enzymolysis 5h under the condition of vacuum-0.05MPa and temperature 60 C fast, by the enzymolysis solution microwave radiation exaraction 45min under the condition of temperature 90 DEG C obtained, with Rotary Evaporators concentrating under reduced pressure, organic solvent is removed, namely Radix Oenotherae erythrosepalae oil is obtained, contain in Radix Oenotherae erythrosepalae oil: r-linoleic acid, magnesium, zinc, copper, vitamin C, E, B6, the effective ingredient such as B5, it is the extremely polynary undersaturated essential fatty acid of one, the endogenous factor of inflammatory that Oleum Arachidis hypogaeae semen tetraenoic acid produces in vivo can be replaced in the process of metabolism in vivo, as prostaglandin, the Prothrombin of leukotrienes and initiation Coagulation test, except anti-inflammatory effect, Radix Oenotherae erythrosepalae oil also has reduction Coagulation test, the effect of antithrombotic,

Step 2: cleaned by lemon fruit, is ground into 40 orders with pulverizer, carries out supersound extraction with ethanol, and solid-liquid ratio is 1:2, the mass concentration of ethanol is 80%, and ultrasonic power is 40KHz, and temperature is 55 DEG C, and extraction time is 30 minutes, be separated with macroporous adsorption resin chromatography, dry, the brown color fine powder obtained is citron extract again, citron extract has and promotes the production of body fluid, and quenches the thirst, drives away summer heat, antiabortive, pharyngalgia xerostomia, gastral cavilty flatulence, hypertension, myocardial infarction, effect of anorexia;

Step 3: by Ampelopsis grossedentata crushed after being dried, cross 30 mesh sieves, obtain Ampelopsis grossedentata coarse powder, to add in Ampelopsis grossedentata coarse powder 15 times of quality containing the protectant aqueous solution of flavone, in aqueous solution, the protectant mass percent of flavone is 0.05%, the pH value of aqueous solution is filter after 3,85 DEG C of heating 30min leave standstill, and obtains Ampelopsis grossedentata water clear liquid, Ampelopsis grossedentata Aqueous extracts clear liquid is heated, vacuum concentration, is cooled to 5 DEG C, crystallization, to the deionized water drip washing adding 5 times of quality in crystal, centrifuge dehydration, microwave drying, obtains Ampelopsis grossedentata extrat;

Step 4: take Pueraria lobota Bud root by described components by weight percent, medicine root of Herba Apii graveolentis, Botrychium japonicum (Prantl) underw, Radix Rubi Setchuenensis, Radix broussonetiae, Bai Guimu root, Fructus Phyllanthi, all medical materials are cut into the thin slice of 2mm, be placed in oven for drying, baking oven set temperature 60 DEG C, make Chinese medicine tablet moisture lower than 5%, take the Semen piptanthi concoloris seed of described components by weight percent, crushed after being dried, cross 50 mesh sieves, obtain Semen piptanthi concoloris coarse powder, by Chinese medicine tablet and the mixing of Semen piptanthi concoloris coarse powder, add the pure water of 10 times amount of mixing medical material gross weight, soak 12h, use special marmite, fine coal ash quantity after described special marmite refers to the calcining added in clay is 1.2 times that common marmite is fired, firing temperature is higher than common marmite 100 DEG C, the raising of fine coal ash quantity can increase the activated carbon constituents in marmite, thus a large amount of negative oxygen ion can be formed make to have strong physical absorption and chemical adsorption capacity, therefore can except the heavy metal ion in anhydrating, stink, rust etc., and effectively can stop the loss of effective ingredient in medical material, improving firing temperature can make the heat-resisting quantity of marmite improve, can more be uniformly dissolved from making medicinal ingredient, intense fire heated and boiled, slow fire boiling is extracted, decoct 3 hours, again add the pure water of 8 times amount, intense fire heated and boiled, slow fire boiling is extracted, decoct 2 hours, merge the extracting solution of twice,

Step 5: take fresh Herba Thysanolaenae maximae by described components by weight percent, bitter mustard, Herba Oberoniae iridifoliae, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle smash to pieces, and the mass concentration adding 5 times amount is 75% alcoholic solution, blender is used to stir 30min, the supernatant is extracted after leaving standstill 12h, carry out 95 DEG C of microwave sterilizating, sterilization time 120s, reclaims the ethanol in filtrate and concentrates, obtained mixture extractum;

Step 6: the mixture extractum mix homogeneously that extracting solution step 4 obtained and step 5 obtain, 3h is left standstill after stirring, then centrifuge 6000r/min centrifugal sediment is used, filter, add Radix Oenotherae erythrosepalae extract, citron extract, the Ampelopsis grossedentata extrat of described components by weight percent more respectively, the Chinese medicine composition of the essential hypertension that namely obtains medical treatment;

Step 7: add lactose 6.8 parts, micropowder silica gel 5.2 parts, polyoxyethylene sorbitan monoleate 4.6 parts by following components by weight percent in the Chinese medicine composition that step 6 is obtained, capsule is made by corresponding Technology, described lactose Main Function is absorption dispersant, described micropowder silica gel Main Function is raising agent, and described polyoxyethylene sorbitan monoleate Main Function is wetting agent.

Clinical trial:

1. clinical case is selected and is divided into groups: inventor collects 120 routine primary hypertension patients altogether, is divided into four groups at random, often organizes 30 people, three groups of test group, one group of matched group, and the data such as four groups of sexes, age, state of an illness there are no significant difference, has comparability.

2. test method: take the Chinese medicinal composition capsules of embodiment 1, embodiment 2, embodiment 3 preparation to respectively test group patient, matched group takes common depressor, takes 2 every day, 10 days is a course for the treatment of, and experimental period is three courses for the treatment of.

3. criterion of therapeutical effect and therapeutic outcome

3.1 criterion of therapeutical effect

(1) fully recover: blood pressure recover normal condition, withdrawal after three months blood pressure normal;

(2) effective: blood pressure reduces, but does not reach normal condition, and after withdrawal, blood pressure does not raise;

(3) invalid: blood pressure is without obviously changing or raising.

3.2 treatment statistical results

Table 1-tetra-group comparitive study

The medicine taken	Case number	Recovery from illness	Effective	Invalid	Untoward reaction	Total effective rate %
							Embodiment 1	30	12	13	5	0	83.3
Embodiment 2	30	16	13	1	0	96.6
							Embodiment 3	30	13	14	3	0	90.0
Common depressor	30	3	16	9	2	63.3

4. conclusion: in clinical trial process, the patient accepting Drug therapy of the present invention finds no any untoward reaction, as seen from the data in Table 1, the hypertensive total effective rate of drugs in idiopathic of the present invention reaches more than 83.3%, be the safe and effective medicine for the treatment of essential hypertension, there is good clinical meaning.

5. clinical individual case

Case 1: Huang, man, 32 years old, occurred before 3 months that intermittent blood pressure raises, develop into gradually and have a dizzy spell, the normal work of impact and life, take Western medicine and control blood pressure, medicine stops rear blood pressure and raises immediately, after the course for the treatment of of Chinese medicinal composition capsules agent of the treatment essential hypertension bringing into use the embodiment of the present invention 1 to prepare two months ago, blood pressure returns to normal range, withdrawal after three courses for the treatment of, withdrawal one month, has no bounce-back up till now.

Case 2: Korea Spro so-and-so, female, 48 years old, heritability primary hypertension patient, its grandfather, father, elder brother suffers from essential hypertension, long-term taking Western medicine controlled release agent, start to occur headache, after half course for the treatment of of Chinese medicinal composition capsules agent of the treatment essential hypertension using the embodiment of the present invention 2 to prepare, blood pressure returns to normal range, take medicine continuously three courses for the treatment of, after half a year, have no recurrence.

Case 3: section, man, 62 years old, primary hypertension patient, long-term alcohol smoking, decreased liver function, pulmonary's easy infection inflammation, intermittent blood pressure raises and causes having a dizzy spell, and cannot normally walk, long-term taking Western medicine slow releasing agent, along with the age increases, slow releasing function worse and worse, after the course for the treatment of of Chinese medicinal composition capsules agent of the treatment essential hypertension using the embodiment of the present invention 3 to prepare, blood pressure starts to reduce, soft tissue swelling alleviates, and after two courses for the treatment of, blood pressure returns to normal range, take 5 courses for the treatment of continuously, drug withdrawal has no recurrence half a year.

Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.

Claims (10)

1. treat the Chinese medicine composition of essential hypertension for one kind, it is characterized in that, component meter by weight, mainly be made up of following raw material: Pueraria lobota Bud root 60 ~ 90 parts, medicine root of Herba Apii graveolentis 55 ~ 80 parts, Botrychium japonicum (Prantl) underw 52 ~ 78 parts, Radix Rubi Setchuenensis 42 ~ 65 parts, Herba Thysanolaenae maximae 40 ~ 58 parts, bitter 38 ~ 56 parts, mustard, Radix broussonetiae 38 ~ 55 parts, Bai Guimu root 35 ~ 52 parts, Herba Oberoniae iridifoliae 36 ~ 48 parts, Semen piptanthi concoloris 34 ~ 46 parts, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle 30 ~ 45 parts, Fructus Phyllanthi 30 ~ 43 parts, Radix Oenotherae erythrosepalae extract 4.2 ~ 5.6 parts, citron extract 3.8 ~ 5.4 parts, Ampelopsis grossedentata extrat 2.8 ~ 4.6 parts.

2. a kind of Chinese medicine composition for the treatment of essential hypertension as claimed in claim 1, it is characterized in that, component meter by weight, is mainly made up of following raw material: Pueraria lobota Bud root 75 parts, medicine root of Herba Apii graveolentis 68 parts, Botrychium japonicum (Prantl) underw 65 parts, Radix Rubi Setchuenensis 54 parts, Herba Thysanolaenae maximae 49 parts, 47 parts, bitter mustard, Radix broussonetiae 46 parts, Bai Guimu root 44 parts, Herba Oberoniae iridifoliae 42 parts, Semen piptanthi concoloris 40 parts, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle 38 parts, Fructus Phyllanthi 37 parts, Radix Oenotherae erythrosepalae extract 4.9 parts, citron extract 4.6 parts, Ampelopsis grossedentata extrat 3.7 parts.

3. a kind of Chinese medicine composition for the treatment of essential hypertension as described in claim 1 ~ 2 any one, it is characterized in that, described Radix Oenotherae erythrosepalae extract is Radix Oenotherae erythrosepalae oil, its extracting method is: after evening primrose seed wash clean, be placed in oven drying, baking oven set temperature 60 DEG C, make its moisture lower than 5%, then ultra micro comminution by gas stream is carried out, cross 100 ~ 120 mesh sieves, obtain evening primrose seed powder, add the distilled water of 10 times amount, add 0.08 times amount mixed enzyme again, enzymolysis 2 ~ 5h under the condition of vacuum-0.03 ~-0.05MPa and temperature 50 ~ 60 DEG C, by the enzymolysis solution microwave radiation exaraction 45min under the condition of temperature 80 ~ 90 DEG C obtained, with Rotary Evaporators concentrating under reduced pressure, organic solvent is removed, namely Radix Oenotherae erythrosepalae oil is obtained.

4. a kind of Chinese medicine composition for the treatment of essential hypertension as claimed in claim 3, is characterized in that, described mixed enzyme to be fully uniformly mixed according to the weight ratio of 4:1:2 by chitinase, cellulase, papain to obtain.

5. a kind of Chinese medicine composition for the treatment of essential hypertension as described in claim 1 ~ 2 any one, it is characterized in that, described citron extract preparation method is: cleaned by lemon fruit, 20 ~ 40 orders are ground into pulverizer, supersound extraction is carried out with ethanol, solid-liquid ratio is 1:(2 ~ 6), the mass concentration of ethanol is 60 ~ 80%, ultrasonic power is 30 ~ 40KHz, temperature is 55 DEG C, and extraction time is 30 minutes, then is separated with macroporous adsorption resin chromatography, drying, the brown color fine powder obtained is citron extract.

6. a kind of Chinese medicine composition for the treatment of essential hypertension as described in claim 1 ~ 2 any one, it is characterized in that, described Ampelopsis grossedentata extrat preparation method is: by Ampelopsis grossedentata crushed after being dried, cross 20 ~ 30 mesh sieves, obtain Ampelopsis grossedentata coarse powder, to add in Ampelopsis grossedentata coarse powder 15 times of quality containing the protectant aqueous solution of flavone, in aqueous solution, the protectant mass percent of flavone is 0.05%, the pH value of aqueous solution is 3, filter after 85 DEG C of heating 30min leave standstill, obtain Ampelopsis grossedentata water clear liquid, Ampelopsis grossedentata Aqueous extracts clear liquid is heated, vacuum concentration, be cooled to 5 DEG C, crystallization, to the deionized water drip washing adding 5 times of quality in crystal, centrifuge dehydration, microwave drying, obtain Ampelopsis grossedentata extrat.

7. a kind of preparation method for the treatment of the Chinese medicine composition of essential hypertension as described in claim 1 ~ 6 any one, is characterized in that, comprise the following steps:

Step one: after evening primrose seed wash clean, be placed in oven drying, baking oven set temperature 60 DEG C, make its moisture lower than 5%, then ultra micro comminution by gas stream is carried out, cross 100 ~ 120 mesh sieves, obtain evening primrose seed powder, add the distilled water of 10 times amount, add 0.08 times amount mixed enzyme again, described mixed enzyme is by chitinase, cellulase, papain is fully uniformly mixed according to the weight ratio of 4:1:2 and obtains, enzymolysis 2 ~ 5h under the condition of vacuum-0.03 ~-0.05MPa and temperature 50 ~ 60 DEG C, by the enzymolysis solution microwave radiation exaraction 45min under the condition of temperature 80 ~ 90 DEG C obtained, with Rotary Evaporators concentrating under reduced pressure, organic solvent is removed, namely Radix Oenotherae erythrosepalae oil is obtained,

Step 2: lemon fruit is cleaned, 20 ~ 40 orders are ground into pulverizer, carry out supersound extraction with ethanol, solid-liquid ratio is 1:(2 ~ 6), the mass concentration of ethanol is 60 ~ 80%, ultrasonic power is 30 ~ 40KHz, temperature is 55 DEG C, and extraction time is 30 minutes, then is separated with macroporous adsorption resin chromatography, drying, the brown color fine powder obtained is citron extract;

Step 3: by Ampelopsis grossedentata crushed after being dried, cross 20 ~ 30 mesh sieves, obtain Ampelopsis grossedentata coarse powder, to add in Ampelopsis grossedentata coarse powder 15 times of quality containing the protectant aqueous solution of flavone, in aqueous solution, the protectant mass percent of flavone is 0.05%, the pH value of aqueous solution is filter after 3,85 DEG C of heating 30min leave standstill, and obtains Ampelopsis grossedentata water clear liquid, Ampelopsis grossedentata Aqueous extracts clear liquid is heated, vacuum concentration, is cooled to 5 DEG C, crystallization, to the deionized water drip washing adding 5 times of quality in crystal, centrifuge dehydration, microwave drying, obtains Ampelopsis grossedentata extrat;

Step 4: take Pueraria lobota Bud root by described components by weight percent, medicine root of Herba Apii graveolentis, Botrychium japonicum (Prantl) underw, Radix Rubi Setchuenensis, Radix broussonetiae, Bai Guimu root, Fructus Phyllanthi, all medical materials are cut into the thin slice of 2mm, be placed in oven for drying, baking oven set temperature 60 DEG C, make Chinese medicine tablet moisture lower than 5%, take the Semen piptanthi concoloris seed of described components by weight percent, crushed after being dried, cross 50 mesh sieves, obtain Semen piptanthi concoloris coarse powder, by Chinese medicine tablet and the mixing of Semen piptanthi concoloris coarse powder, add the pure water of 8 ~ 10 times amount of mixing medical material gross weight, soak 8 ~ 12h, use special marmite, intense fire heated and boiled, slow fire boiling is extracted, decoct 2-3 hour, again add the pure water of 6 ~ 8 times amount, intense fire heated and boiled, slow fire boiling is extracted, decoct 1 ~ 2 hour, merge the extracting solution of twice,

Step 5: take fresh Herba Thysanolaenae maximae by described components by weight percent, bitter mustard, Herba Oberoniae iridifoliae, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle smash to pieces, and the mass concentration adding 5 times amount is 75% alcoholic solution, blender is used to stir 30min, the supernatant is extracted after leaving standstill 12h, carry out 85 ~ 95 DEG C of microwave sterilizating, sterilization time 90 ~ 120s, reclaims the ethanol in filtrate and concentrates, obtained mixture extractum;

Step 6: the mixture extractum mix homogeneously that extracting solution step 4 obtained and step 5 obtain, 3h is left standstill after stirring, then centrifuge 5000 ~ 6000r/min centrifugal sediment is used, filter, add Radix Oenotherae erythrosepalae extract, citron extract, the Ampelopsis grossedentata extrat of described components by weight percent more respectively, the Chinese medicine composition of the essential hypertension that namely obtains medical treatment.

8. a kind of preparation method for the treatment of the Chinese medicine composition of essential hypertension as claimed in claim 7, is characterized in that described Chinese medicine composition to make capsule.

9. a kind of preparation method for the treatment of the Chinese medicine composition of essential hypertension as claimed in claim 8, is characterized in that the preparation method of described capsule comprises the following steps:

Step one: after evening primrose seed wash clean, be placed in oven drying, baking oven set temperature 60 DEG C, make its moisture lower than 5%, then ultra micro comminution by gas stream is carried out, cross 100 ~ 120 mesh sieves, obtain evening primrose seed powder, add the distilled water of 10 times amount, add 0.08 times amount mixed enzyme again, described mixed enzyme is by chitinase, cellulase, papain is fully uniformly mixed according to the weight ratio of 4:1:2 and obtains, enzymolysis 2 ~ 5h under the condition of vacuum-0.03 ~-0.05MPa and temperature 50 ~ 60 DEG C, by the enzymolysis solution microwave radiation exaraction 45min under the condition of temperature 80 ~ 90 DEG C obtained, with Rotary Evaporators concentrating under reduced pressure, organic solvent is removed, namely Radix Oenotherae erythrosepalae oil is obtained,

Step 2: lemon fruit is cleaned, 20 ~ 40 orders are ground into pulverizer, carry out supersound extraction with ethanol, solid-liquid ratio is 1:(2 ~ 6), the mass concentration of ethanol is 60 ~ 80%, ultrasonic power is 30 ~ 40KHz, temperature is 55 DEG C, and extraction time is 30 minutes, then is separated with macroporous adsorption resin chromatography, drying, the brown color fine powder obtained is citron extract;

Step 3: by Ampelopsis grossedentata crushed after being dried, cross 20 ~ 30 mesh sieves, obtain Ampelopsis grossedentata coarse powder, to add in Ampelopsis grossedentata coarse powder 15 times of quality containing the protectant aqueous solution of flavone, in aqueous solution, the protectant mass percent of flavone is 0.05%, the pH value of aqueous solution is filter after 3,85 DEG C of heating 30min leave standstill, and obtains Ampelopsis grossedentata water clear liquid, Ampelopsis grossedentata Aqueous extracts clear liquid is heated, vacuum concentration, is cooled to 5 DEG C, crystallization, to the deionized water drip washing adding 5 times of quality in crystal, centrifuge dehydration, microwave drying, obtains Ampelopsis grossedentata extrat;

Step 4: take Pueraria lobota Bud root by described components by weight percent, medicine root of Herba Apii graveolentis, Botrychium japonicum (Prantl) underw, Radix Rubi Setchuenensis, Radix broussonetiae, Bai Guimu root, Fructus Phyllanthi, all medical materials are cut into the thin slice of 2mm, be placed in oven for drying, baking oven set temperature 60 DEG C, make Chinese medicine tablet moisture lower than 5%, take the Semen piptanthi concoloris seed of described components by weight percent, crushed after being dried, cross 50 mesh sieves, obtain Semen piptanthi concoloris coarse powder, by Chinese medicine tablet and the mixing of Semen piptanthi concoloris coarse powder, add the pure water of 8 ~ 10 times amount of mixing medical material gross weight, soak 8 ~ 12h, use special marmite, intense fire heated and boiled, slow fire boiling is extracted, decoct 2-3 hour, again add the pure water of 6 ~ 8 times amount, intense fire heated and boiled, slow fire boiling is extracted, decoct 1 ~ 2 hour, merge the extracting solution of twice,

Step 5: take fresh Herba Thysanolaenae maximae by described components by weight percent, bitter mustard, Herba Oberoniae iridifoliae, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle smash to pieces, and the mass concentration adding 5 times amount is 75% alcoholic solution, blender is used to stir 30min, the supernatant is extracted after leaving standstill 12h, carry out 85 ~ 95 DEG C of microwave sterilizating, sterilization time 90 ~ 120s, reclaims the ethanol in filtrate and concentrates, obtained mixture extractum;

Step 6: the mixture extractum mix homogeneously that extracting solution step 4 obtained and step 5 obtain, 3h is left standstill after stirring, then centrifuge 5000 ~ 6000r/min centrifugal sediment is used, filter, add Radix Oenotherae erythrosepalae extract, citron extract, the Ampelopsis grossedentata extrat of described components by weight percent more respectively, the Chinese medicine composition of the essential hypertension that namely obtains medical treatment;

Step 7: add lactose 6.8 parts, micropowder silica gel 5.2 parts, polyoxyethylene sorbitan monoleate 4.6 parts in the Chinese medicine composition that step 6 is obtained by following components by weight percent, make capsule by corresponding Technology.

10. a kind of preparation method for the treatment of the Chinese medicine composition of essential hypertension as described in claim 7 or 9 any one, it is characterized in that described special marmite refer to the calcining added in clay after fine coal ash quantity be 1.2 times that common marmite is fired, firing temperature is higher than common marmite 100 DEG C.