CN102343050B

CN102343050B - Eye ointment for treating eye diseases

Info

Publication number: CN102343050B
Application number: CN2011103047487A
Authority: CN
Inventors: 贾道忠
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-10-10
Filing date: 2011-10-10
Publication date: 2013-05-22
Anticipated expiration: 2031-10-10
Also published as: CN102343050A

Abstract

The invention discloses an eye ointment for treating eye diseases. The eye ointment is prepared from the following raw materials in parts by weight: chrysanthemum, pen grass, fragrant solomonseal rhizome, mint, divaricate saposhnikovia root, mulberry leaf, amur corktree bark, tabasheer, notopterygium root, goat gall, borneol, coptis root, wild celery, snake gall, dahurian angelica root, heather honey, calculus bovis, fineleaf schizonepeta herb, common anemarrhena, subopposite milkwort herb, wild ginger, Chinese angelica, tea leaf and sesame oil. The entire formula has the effects of clearing away heat and toxic materials, promoting blood circulation to dispel blood stasis, resisting bacteria, reducing inflammation, clearing liver and improving vision, can be used for treating various eye diseases such as puffy eyes, lachrymation, eye dryness and itching, bursting pain, eye white congestion, conjunctivitis, viral conjunctivitis, retinitis, blurred vision and the like, has a simple preparation process, and is fully absorbed by patients.

Description

A kind of eye ointment for the treatment of ocular disease

Technical field

The present invention relates to a kind of Chinese patent medicine of the preparation take Chinese medicine as raw material, especially a kind of eye ointment for the treatment of ocular disease.

Background technology

At present, the medicament categories quantity of eye ointment that is used for the treatment of ophthalmic diseases is few, be divided into chemical synthetic drug and Chinese medicine preparation two classes, chemical synthetic drug is due to the limitation of clinical efficacy and toxic and side effects, practical effect is also unsatisfactory, and Chinese medicine preparation is well received by the public due to evident in efficacy and low toxic and side effects, but exist the ophthalmic for the treatment of single, patient's absorption difference, the shortcoming that manufacturing process is loaded down with trivial details.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of eye ointment for the treatment of ocular disease, can solve the shortcoming of existing eye ointment, can treat multiple ophthalmic, and manufacturing process is simple, the patient absorbs fully.

For solving the problems of the technologies described above, the technical solution adopted in the present invention is: a kind of eye ointment for the treatment of ocular disease, and the ointment that it is made by the raw material of following weight portion proportioning:

Flos Chrysanthemi 5～15 Herba equiseti ramosissimi 5～15 Rhizoma Polygonati Odorati 10～20 Herba Menthaes 10～20

Radix Saposhnikoviae 10～20 Folium Mori 5～15 Cortex Phellodendri 5～15 Concretio silicea Bambusae seu schizostachyi 10～20

Rhizoma Et Radix Notopterygii 5～15 Fel Caprae seu Ovis 15～25 Borneolum Syntheticum 5～15 Rhizoma Coptidis 10～20

Radix Angelicae Pubescentis 10～20 Fel Serpentis 15～25 Radix Angelicae Dahuricae 5～15 SHIMI 10～20

Calculus Bovis 5～15 Herba Schizonepetae 5～15 Rhizoma Anemarrhenae 5～15 Polygala subopposita S.K.Chen 10～20

Herba Asari 5～15 Radix Angelicae Sinensis 5～15 Folium Camelliae sinensis 5～15 Oleum Sesami 15～25.

The weight portion proportioning of each raw material is:

Flos Chrysanthemi 10 Herba equiseti ramosissimi 10 Rhizoma Polygonati Odorati 15 Herba Menthaes 15

Radix Saposhnikoviae 15 Folium Mori 10 Cortex Phellodendri 10 Concretio silicea Bambusae seu schizostachyi 15

Rhizoma Et Radix Notopterygii 10 Fel Caprae seu Ovis 20 Borneolum Syntheticum 10 Rhizoma Coptidis 15

Radix Angelicae Pubescentis 15 Fel Serpentis 20 Radix Angelicae Dahuricae 10 SHIMI 15

Calculus Bovis 10 Herba Schizonepetae 10 Rhizoma Anemarrhenae 10 Polygala subopposita S.K.Chen 15

Herba Asari 10 Radix Angelicae Sinensis 10 Folium Camelliae sinensis 10 Oleum Sesami 20.

Described eye ointment is unguentum, and making step is as follows:

1, the Flos Chrysanthemi of above-mentioned weight portion, Herba equiseti ramosissimi, Rhizoma Polygonati Odorati, Herba Menthae, Radix Saposhnikoviae, Folium Mori, Cortex Phellodendri, Rhizoma Et Radix Notopterygii, Rhizoma Coptidis, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Herba Schizonepetae, the Rhizoma Anemarrhenae, Polygala subopposita S.K.Chen, Herba Asari, Radix Angelicae Sinensis, Folium Camelliae sinensis are decocted filtered in 1 hour, filtering residue is repeated to decoct after twice the medicine juice of three times is merged again decoct with slow fire;

2, the SHIMI with above-mentioned weight portion is contained in Fel Caprae seu Ovis, tightening the medicine juice of putting into step 1 after Fel Caprae seu Ovis decocts, after having dissolved fully, sheep bile and SHIMI pull the Fel Caprae seu Ovis skin out, medicine juice is fried in shallow oil into put into Oleum Sesami after golden yellow and do not stop to stir, make the complete mix homogeneously of Oleum Sesami and medicine juice, when medicine juice was fried in shallow oil to scattered paste shape, comparison thickness, the juice of putting into Fel Serpentis stirred evenly;

3, from fire, Calculus Bovis, Concretio silicea Bambusae seu schizostachyi and ground Borneolum Syntheticum are put into the medicine juice that step 2 is fried in shallow oil, namely get eye ointment of the present invention after stirring evenly.

The pharmacology of each crude drug of the present invention is as follows:

Flos Chrysanthemi: contain volatile oil, flavonoid and aminoacid, trace element etc., have loose wind heat clearing away, the effect that suppressing the hyperactive liver makes eye bright.

Herba equiseti ramosissimi: be rich in multiple silicate and tannin, have ventilation, make eye bright, sharp nine orifices is controlled and is got injured by a fall, and removing food stagnancy is stagnant, the effect that antitussive reduces phlegm.

Rhizoma Polygonati Odorati: contain vitamin A, steroid glycoside etc., have nourishing YIN and moistening the lung; The effect of nourishing the stomach to promote the production of body fluid.

Herba Menthae: be rich in menthol and menthone, have the wind heat of dispersing, clearing throat, rash detoxifcation, dispersing the stagnated live-QI to relieve the stagnation of QI and the effect such as antipruritic.

Radix Saposhnikoviae: mainly contain the compositions such as volatility, chromogen ketone, Coumarins, polysaccharide, organic acid, polyacetylene class, glyceride type, have the effects such as analgesic, analgesia, calmness, antiinflammatory, antibiotic, antitumor, raising body's immunity, antiallergic, anticoagulation.

Folium Mori: contain polysaccharide, alkaloid and flavone etc., have dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing liver-YANG, liver heat removing and eyesight improving, the effect of cooling blood for hemostasis.

Cortex Phellodendri: contain the multiple alkaloids such as berberine, phellodendrine, have heat clearing and damp drying, eliminating fire and detoxication is brought down a fever except the effect of steaming.

Concretio silicea Bambusae seu schizostachyi: contain alkaloid and several amino acids, organic acid, have the effect of removing heat-phlegm, the arresting convulsion of the cool heart.

Rhizoma Et Radix Notopterygii: contain volatile oil, coumarin, saccharide, aminoacid, organic acid and sterol etc., have dispersing wind-cold, the effect of wind-expelling pain-stopping.

Fel Caprae seu Ovis: mainly contain bile salt, bile pigments, mucin, cholesterol, lecithin, sodium bicarbonate etc., have and relieve inflammation or internal heat, make eye bright, the effect of detoxifcation.

Borneolum Syntheticum: contain multiple ter penoids, have logical all keys, loose stagnated fire, removing nebula makes eye bright, the effect of reducing swelling and alleviating pain.

Rhizoma Coptidis: main component is berberine (berberine), has heat clearing and damp drying, the effect of eliminating fire and detoxication.

Radix Angelicae Pubescentis: contain the Coumarins compositions such as terpenoid and osthole, have wind-damp dispelling is arranged, pain relieving, the effect of inducing sweat.

Fel Serpentis: contain abundant trace copper, ferrum, calcium, magnesium, vitamin C, E etc., have heat-clearing and toxic substances removing, the damp eliminating of dispeling the wind, the effect that makes eye bright and clear away heart-fire.

The Radix Angelicae Dahuricae: contain volatile oil, coumarin and derivant thereof have wind-damp dispelling, the evacuation of pus of invigorating blood circulation, the effect of granulation promoting pain relieving.

SHIMI: contain abundant nutritional labeling, as various saccharides such as fructose, glucoses, protein, aminoacid, plurality of enzymes, vitamin A, B, C, K, pantothenic acid, folic acid, and the trace element such as ferrum, manganese, copper, nickel have the effect of the lung moistening and production of body fluid promoting, cough-relieving and middle lung benefiting, the irritability of releiving, YIN nourishing, seasoning, antihalitosis, solution salt brine poison.

Calculus Bovis: contain the composition that more than ten kind of human body such as bile acid, cholesterol, lecithin, bilirubin, ergosterol, several amino acids, calcium salt and copper, ferrum, magnesium, vitamin D is badly in need of, have and clear away heart-fire, eliminating phlegm is had one's ideas straightened out, cool liver, endogenous wind stopping, the effect of detoxifcation.

Herba Schizonepetae: contain terpenoid, terpene alcohols, aldehydes, esters and alkane derivative etc., have the loose wind that induces sweat, the effect of rash.

The Rhizoma Anemarrhenae: contain the Multiple components such as saponin, flavone and lignanoid, have clearing away heat-fire, the effect of promoting the production of body fluid and moisturizing.

Polygala subopposita S.K.Chen: have heat-clearing and toxic substances removing; The effect of dissipating blood stasis hemostasis.

Herba Asari: contain methyleugenol, safrole, 1-ally-3,4-methy-lene dioxy benzene oil, eucarvone, Borneolum Syntheticum etc., have the cold expelling of inducing sweat; Wind-expelling pain-stopping; Warming the lung to resolve fluid-retention; Sensible effect.

Radix Angelicae Sinensis: contain water miscible have ferulic acid, succinic acid, nicotinic acid, uracil, adenine etc., having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation.

Folium Camelliae sinensis: contain abundant nutrient substance, as protein, aminoacid, saccharide, lipid, vitamin, inorganic salt and trace element etc., have and quench the thirst, help digestion, expectorant, dredging water passages, make eye bright, beneficial think of, relieving restlessness, go greasy effect.

Oleum Sesami: contain the mineral such as Semen Sesami acid, protein, sesamin, vitamin E, lecithin, sucrose, calcium, phosphorus, ferrum, have the effect of loosening bowel to relieve constipation, removing toxic substances and promoting granulation.

A kind of eye ointment for the treatment of ocular disease provided by the invention, beneficial effect is as follows:

1, whole formula has the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, anti-inflammation, liver heat removing and eyesight improving, can treat multiple ophthalmic, and as inflamed eyes, shed tears, eyes are dry and astringent itches, swollen the swelling and ache of acid.White of the eye hyperemia, conjunctivitis, viral conjunctivitis, retinitis, blurred vision are unclear etc.

2, to select the natural edible-plant medicine be raw material to formula of the present invention, and each component meets respectively the distinguish the flavor of various ophthalmics of comprehensive function treatment of Chinese medicine of pharmaceutical control law regulation utilization, can a side multiplex and little to the human body toxic and side effects, easily absorbs, and is difficult for recurrence, and curative effect is good.

3, this formula also has the effect of pain relieving, granulation promoting, skin incrustation, and can stop rapidly at short notice the pain of burn due to hot liquid or fire, to the acute and chronic otitis media, not suppurative in ear pain, and burn due to hot liquid or fire has good therapeutic effect, by the tracing study to course for the treatment of (30 days) of the 15 routine otitis media patients that smear this medicine and 5 routine burn due to hot liquid or fire patients, recovery effects is good, effective percentage 100%.。

For showing medicine of the present invention to the therapeutic effect of various ophthalmics, the present invention uses the eye disease patient of this medicine to carry out clinical follow-up observation to 180 examples, and the observation period is 30 days courses for the treatment of.

Using method: with the eye ointment bottling sealing that makes, take a bit at every turn and be applied to eyelid, three times on the one.The clinical follow-up observation result is as shown in table 1.

Table 1 uses the curative effect (n, %) of medicine of the present invention

Figure 2011103047487100002DEST_PATH_IMAGE001

The therapeutic effect of medicine of the present invention can also show from the therapeutic process of following model case:

Model case 1, Lee, man, 26 years old, symptom: ignore after staying up late for a long time that the aftersensation eyes are dry and astringent and itching, after one week, sb.'s illness took a turn for the worse, and furious shedding tears incessantly is diagnosed as conjunctivitis, and medication is after 7 days, the furious remission of shedding tears, after 1 course for the treatment of of medication, transference cure checks that eyes recover normal.

Model case 2, what certain, the female, 30 years old, symptom: use computer to feel the eyes swelling and pain after a few minutes, blurred vision was unclear, medication after 5 days the eyes distending pain obviously alleviate, the ongoing operation computer also without the ophthalmic bloated performance, continued medication after 25 days more than 1 hour, all diseases disappear.

The specific embodiment

Embodiment 1

Get Flos Chrysanthemi 5g, Herba equiseti ramosissimi 5g, Rhizoma Polygonati Odorati 10g, Herba Menthae 10g; Radix Saposhnikoviae 10g, Folium Mori 5g, Cortex Phellodendri 5g, Concretio silicea Bambusae seu schizostachyi 10g; Rhizoma Et Radix Notopterygii 5g, Fel Caprae seu Ovis 15g, Borneolum Syntheticum 5g, Rhizoma Coptidis 10g; Radix Angelicae Pubescentis 10g, Fel Serpentis 15g, Radix Angelicae Dahuricae 5g, SHIMI 10g; Calculus Bovis 5g, Herba Schizonepetae 5g, Rhizoma Anemarrhenae 5g, Polygala subopposita S.K.Chen 10g; Herba Asari 5g, Radix Angelicae Sinensis 5g, Folium Camelliae sinensis 5g, Oleum Sesami 15g.

The making step of eye ointment is as follows:

1, the Flos Chrysanthemi of above-mentioned weight, Herba equiseti ramosissimi, Rhizoma Polygonati Odorati, Herba Menthae, Radix Saposhnikoviae, Folium Mori, Cortex Phellodendri, Rhizoma Et Radix Notopterygii, Rhizoma Coptidis, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Herba Schizonepetae, the Rhizoma Anemarrhenae, Polygala subopposita S.K.Chen, Herba Asari, Radix Angelicae Sinensis, Folium Camelliae sinensis are decocted filtered in 1 hour, filtering residue is repeated to decoct after twice the medicine juice of three times is merged again decoct with slow fire;

2, the SHIMI with above-mentioned weight is contained in Fel Caprae seu Ovis, tightening the medicine juice of putting into step 1 after Fel Caprae seu Ovis decocts, after having dissolved fully, sheep bile and SHIMI pull the Fel Caprae seu Ovis skin out, medicine juice is fried in shallow oil into put into Oleum Sesami after golden yellow and do not stop to stir, make the complete mix homogeneously of Oleum Sesami and medicine juice, when medicine juice was fried in shallow oil to scattered paste shape, comparison thickness, the juice of putting into Fel Serpentis stirred evenly;

Embodiment 2

Get Flos Chrysanthemi 10g, Herba equiseti ramosissimi 10g, Rhizoma Polygonati Odorati 15g, Herba Menthae 15g; Radix Saposhnikoviae 15g, Folium Mori 10g, Cortex Phellodendri 10g, Concretio silicea Bambusae seu schizostachyi 15g; Rhizoma Et Radix Notopterygii 10g, Fel Caprae seu Ovis 20g, Borneolum Syntheticum 10g, Rhizoma Coptidis 15g; Radix Angelicae Pubescentis 15g, Fel Serpentis 20g, Radix Angelicae Dahuricae 10g, SHIMI 15g; Calculus Bovis 10g, Herba Schizonepetae 10g, Rhizoma Anemarrhenae 10g, Polygala subopposita S.K.Chen 15g; Herba Asari 10g, Radix Angelicae Sinensis 10g, Folium Camelliae sinensis 10g, Oleum Sesami 20.

The making step of eye ointment is as follows:

Embodiment 3

Get Flos Chrysanthemi 15g, Herba equiseti ramosissimi 15g, Rhizoma Polygonati Odorati 20g, Herba Menthae 20g; Radix Saposhnikoviae 20g, Folium Mori 15g, Cortex Phellodendri 15g, Concretio silicea Bambusae seu schizostachyi 20g; Rhizoma Et Radix Notopterygii 15g, Fel Caprae seu Ovis 25g, Borneolum Syntheticum 15g, Rhizoma Coptidis 20g; Radix Angelicae Pubescentis 20g, Fel Serpentis 25g, Radix Angelicae Dahuricae 15g, SHIMI 20g; Calculus Bovis 15g, Herba Schizonepetae 15g, Rhizoma Anemarrhenae 15g, Polygala subopposita S.K.Chen 20g; Herba Asari 15g, Radix Angelicae Sinensis 15g, Folium Camelliae sinensis 15g, Oleum Sesami 25g.

The making step of eye ointment is as follows:

Claims

1. eye ointment for the treatment of ocular disease is characterized in that the ointment that it is made by the raw material of following weight portion proportioning:

Herba Asari 5～15 Radix Angelicae Sinensis 5～15 Folium Camelliae sinensis 5～15 Oleum Sesami 15～25;

The preparation method of this eye ointment is as follows:

1) Flos Chrysanthemi of above-mentioned weight portion, Herba equiseti ramosissimi, Rhizoma Polygonati Odorati, Herba Menthae, Radix Saposhnikoviae, Folium Mori, Cortex Phellodendri, Rhizoma Et Radix Notopterygii, Rhizoma Coptidis, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Herba Schizonepetae, the Rhizoma Anemarrhenae, Polygala subopposita S.K.Chen, Herba Asari, Radix Angelicae Sinensis, Folium Camelliae sinensis are decocted filtered in 1 hour, filtering residue is repeated to decoct after twice the medicine juice of three times is merged again decoct with slow fire;

2) SHIMI with above-mentioned weight portion is contained in Fel Caprae seu Ovis, tightening the medicine juice of putting into step 1 after Fel Caprae seu Ovis decocts, after having dissolved fully, sheep bile and SHIMI pull the Fel Caprae seu Ovis skin out, medicine juice is fried in shallow oil into put into Oleum Sesami after golden yellow and do not stop to stir, make the complete mix homogeneously of Oleum Sesami and medicine juice, when medicine juice was fried in shallow oil to scattered paste shape, comparison thickness, the juice of putting into Fel Serpentis stirred evenly;

3) from fire, Calculus Bovis, Concretio silicea Bambusae seu schizostachyi and ground Borneolum Syntheticum are put into step 2) medicine juice fried in shallow oil, namely get described eye ointment after stirring evenly.

2. a kind of eye ointment for the treatment of ocular disease according to claim 1 is characterized in that the weight portion proportioning of each raw material is: