CN104922299A - Traditional Chinese medicine healthcare oral liquid used for preventing and treating diabetic retinopathy - Google Patents
Traditional Chinese medicine healthcare oral liquid used for preventing and treating diabetic retinopathy Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicine healthcare oral liquid for preventing and treating diabetic retinopathy. The raw material formula used for preparing 1000 parts of the healthcare oral liquid comprises, by weight, 5-10 parts of astaxanthin, 10-15 parts of concha haliotidis, 8-12 parts of rhodiola rosea, 10-15 parts of ligusticum wallichii, 15-20 parts of panax notoginseng, 10-13 parts of mulberries, 8-12 parts of red paeony roots, 10-15 parts of schisandra chinensis, 10-16 parts of wolfberries, 10-18 parts of herba epimedii, 15-20 parts of semen cassiae, 10-15 parts of chrysanthemums, 12-18 parts of roots of kudzu vine, 10-15 parts of rehmannia glutinosa, 8-12 parts of angelica sinensis, 5-10 parts of silybum marianum, 5-10 parts of cortex moutan, 10-15 parts of cornus officinalis, 10-15 parts of radix astragali and 10-15 parts of stevia rebaudiana, and is prepared by adopting the technology including ultrasonic wave-assisted extraction, naphtha distillation, decoction with water and alcohol extraction. The traditional Chinese medicine healthcare oral liquid has the advantages of good efficacy, safety without side effects, convenience in drinking and the like.
Description
Technical field
The present invention relates to a kind of herbal health care oral liquid of prevention and therapy diabetic retinopathy, particularly a kind of health care oral liquid made for raw material with marine active substance and vegetable Chinese herbal medicine, belong to herbal health care field.
Background technology
Diabetes are a kind of common metabolic diseases, can cause the extensive infringement of body tissue, multiple organ.Wherein diabetic renal papillary necrosis is one of serious complication of diabetes, it is again a kind of common diseases causing blindness, for one of universally acknowledged four large main diseases causing blindnesses, its sickness rate and blind rate are in ascendant trend year by year, there is no the desirable Western medicine of a kind of curative effect or tcm product for this disease at present, the active drug therefore exploring and develop treatment of diabetic retinopathy change is necessary and urgent.
Chinese herbal medicine is the rarity of Chinese traditional culture, along with the progressively raising of people's lives, the health care consciousness of people strengthens gradually, demand in disperse blood stasis and dredge collateral, supplementing QI and nourishing YIN, hemostasis improving eyesight, alleviating asthenopia, pre-myopia prevention etc. increases day by day, Chinese herbal medicine in this field health food development process in occupation of innate advantage condition.For passing on Chinese herbal medicine culture of long standing and well established, meet the demand of the people to health care, the present invention chooses the Chinese herbal medicine with effects such as QI invigorating tonification, strengthening the body resistance, reducing blood sugar and blood fats, develops the herbal health care oral liquid with prevention and therapy diabetic retinopathy.
Summary of the invention
For overcoming the deficiency of existing prevention and therapy diabetic retinopathy product technology, the object of the present invention is to provide a kind of herbal health care oral liquid with prevention and therapy diabetic retinopathy health-care effect.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
The invention provides a kind of herbal health care oral liquid of prevention and therapy diabetic retinopathy, it is characterized in that: in 1000 portions of oral liquids, raw material of Chinese medicine and quality proportioning are: astaxanthin 5 ~ 10 parts, Concha Haliotidis 10 ~ 15 parts, Radix Rhodiolae 8 ~ 12 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Radix Notoginseng 15 ~ 20 parts, 10 ~ 13 parts, Fructus Mori, Radix Paeoniae Rubra 8 ~ 12 parts, Fructus Schisandrae Chinensis 10 ~ 15 parts, Fructus Lycii 10 ~ 16 parts, Herba Epimedii 10 ~ 18 parts, Semen Cassiae 15 ~ 20 parts, Flos Chrysanthemi 10 ~ 15 parts, Radix Puerariae 12 ~ 18 parts, 10 ~ 15 parts, Radix Rehmanniae Preparata, Radix Angelicae Sinensis 8 ~ 12 parts, Herba Silybi mariani 5 ~ 10 parts, Cortex Moutan 5 ~ 10 parts, Fructus Corni 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Folium Stevlae Rebaudianae 10 ~ 15 parts.
The preferred technical solution of the present invention is: a kind of herbal health care oral liquid of prevention and therapy diabetic retinopathy, is characterized in that: its raw material of Chinese medicine and quality proportioning are: astaxanthin 8 parts, Concha Haliotidis 13 parts, Radix Rhodiolae 12 parts, Rhizoma Chuanxiong 12 parts, Radix Notoginseng 16 parts, 12 parts, Fructus Mori, Radix Paeoniae Rubra 10 parts, Fructus Schisandrae Chinensis 14 parts, Fructus Lycii 15 parts, Herba Epimedii 15 parts, Semen Cassiae 18 parts, Flos Chrysanthemi 12 parts, Radix Puerariae 15 parts, 12 parts, Radix Rehmanniae Preparata, Radix Angelicae Sinensis 10 parts, Herba Silybi mariani 7 parts, Cortex Moutan 8 parts, Fructus Corni 13 parts, the Radix Astragali 12 parts, Folium Stevlae Rebaudianae 13 parts.
The invention provides a kind of herbal health care oral liquid of prevention and therapy diabetic retinopathy, it is characterized in that being prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, removes impurity etc., weighs according to aforementioned proportion;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after astaxanthin, Concha Haliotidis, Radix Rhodiolae, Rhizoma Chuanxiong, Radix Notoginseng, Radix Paeoniae Rubra, Fructus Schisandrae Chinensis, Herba Epimedii, Semen Cassiae, Flos Chrysanthemi, Radix Puerariae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Herba Silybi mariani, Cortex Moutan, Fructus Corni, the Radix Astragali, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. by Fructus Mori, Fructus Lycii mixing, add 2 ~ 3 times of pure water, making beating, then adds 1 ~ 2% pectase, enzymolysis 10 ~ 20min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 3 ~ 5 times of pure water after raw material mixing, then raw materials quality is added than 2 ~ 3% cellulase, 1 ~ 2% non-starch polysaccharide enzyme, enzymolysis 30 ~ 60min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 3 ~ 5 times amount in Chinese herbal medicine residue, collect volatile oil 8 ~ 10h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.5 ~ 2.0% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2 ~ 3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5 ~ 2h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 4 ~ 6 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1 ~ 1.5h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.10 ~ 0.15% and the sweeting agent of 1 ~ 2%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 5 ~ 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
The mixture of one or more that what above-mentioned sweeting agent was selected is in xylitol, oligomeric isomaltose, Mel.
Marine active substance of the present invention and Chinese medicine combination are selected prescriptions under Traditional Chinese medical theory and practical advice.In marine active substance of the present invention and Chinese medicine composition: (1) astaxanthin is the one of carotenoid, for a kind of stronger Natural antioxidant, research shows, astaxanthin is easily via blood brain barrier and cell membrane, effectively can prevent the damage of amphiblestroid oxidation and photoreceptor cell，photosensory cell, especially comparatively phylloxanthin is more remarkable for macular degeneration effect; (2) Concha Haliotidis is the shell of Carnis Haliotidis, main containing calcium carbonate. also containing the iodine of organic and a small amount of magnesium, ferrum, silicate, sulfate, phosphate, chloride and denier, there is the effect such as suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving, be usually used in headache dizzy, cataract, blurring of vision, optic atrohic blindness nyctalopia etc.; (3) Radix Rhodiolae energy improving water flood, blood-enriching and blood-promoting circulation, anti-cerebral anoxia, resisting fatigue, promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, change become silted up detumescence, antipyreticly to bring down a fever, nourish the effects such as vigour; (4) Rhizoma Chuanxiong is the dry rhizome of samphire Rhizoma Chuanxiong, medicine first choice of system's treatment headache, is usually used in that menoxenia, amenorrhea dysmenorrhea, the stasis of blood in puerperal stagnant raw meat pain, lump in the abdomen lump, pain in chest and hypochondrium, headache are dizzy, the prevention and therapy of anemofrigid-damp arthralgia, traumatic injury, ulcer sores etc.; (5) Radix Notoginseng has dissipating blood stasis hemostasis, and effect of subduing swelling and relieving pain, cures mainly spitting of blood, and spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, and tumbling down swells and ache; (6) Fructus Mori contains abundant activated protein, provitamin A, B
1, B
2, PP and C, aminoacid, malic acid, succinic acid, tartaric acid, carotene, mineral calcium, phosphorus, ferrum, copper, the composition such as zinc, there is raising body immunity there is the multiple efficacies such as slow down aging looks improving and the skin nourishing, be described as " the best health fruit of 21st century " by medical circle; (7) Radix Paeoniae Rubra has the effects such as clots absorbing, pain relieving, removing heat from blood, detumescence, cures mainly and controls the stagnant amenorrhea of the stasis of blood, hernia abdominal mass is gathered, suffers from abdominal pain, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle, injury from falling down; (8) Fructus Schisandrae Chinensis is containing compositions such as saccharide, fatty oil, volatile oil, malic acid, citric acid, tartaric acid, vitamin Cs, can strengthen the process of excitation of central nervous system, also can strengthen process of inhibition, make it mutually balance, improve corticocerebral regulating action; Can work ratio be improved, lessen fatigue; Blood pressure can be regulated, cardiac function enhancing; Can excited breathe, and eliminate the phlegm, antitussive effect; Bile secretion can be promoted, reduce hepatitis patient serum's glutamate pyruvate transaminase, have certain protective role to hepatocyte; Can gastric secretion be regulated, excited uterus, and promote vision, audition, improve the resolving ability of skin receptor; (9) Fructus Lycii is famous and precious medical material and tonic, and the saying Compendium of Material Medica that the traditional Chinese medical science has very early " medlar health preserving " is recorded: " nourishing the liver to improve visual acuity is calmed the nerves for Fructus Lycii, kidney-tonifying sperm-generating, makes us long-lived, has the effects such as nourishing the liver, nourishing kidney, lung moistening; (10) Herba Epimedii has the effects such as kidney-replenishing, bone and muscle strengthening, wind-damp dispelling; (11) Semen Cassiae has the function of liver heat removing and eyesight improving, relieving constipation, cures mainly hypertension, headache, dizzy, the disease such as acute conjunctivitis, corneal ulcer, glaucoma, carbuncle furuncle infections; (12) Flos Chrysanthemi sweet, be slightly cold, there is loose wind heat, suppressing the hyperactive liver improving eyesight, disappear and cough effect of pain relieving, be used for the treatment of the disease Be very effective such as headache is dizzy, conjunctival congestion and swelling pain, anemopyretic cold, cough, effect (13) Radix Puerariae also with refreshment has the merit of expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal; Be usually used in exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura is thirsty, the deficiency of YIN is quenched one's thirst, diarrhea of heat type hematodiarrhoea, diarrhea due to hypofunction of the spleen; (14) Radix Rehmanniae Preparata has another name called Radix Rehmanniae Preparata or throws oneself on the ground, belong to goatweed, be a kind of first-class Chinese crude drug, there is YIN nourishing effect of enriching blood, can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, also diseases such as can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, pass out semen, quench one's thirst is one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main component; (15) Radix Angelicae Sinensis has to enrich blood and invigorates blood circulation, menstruction regulating and pain relieving, and the effects such as loosening bowel to relieve constipation, for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores; (16) Herba Silybi mariani has heat-clearing and toxic substances removing, protects the liver, function of gallbladder promoting, protects brain, the effects such as anti-X-ray; (17) Cortex Moutan, bitter, pungent, be slightly cold, GUIXIN, liver, kidney channel, have the effects such as clearing away heat and cooling blood, activating blood circulation to dissipate blood stasis, reducing the asthenic fever; (18) Fructus Corni, have another name called Fructus Corni, medicine Fructus Jujubae, real Fructus Jujubae, Fructus Corni, meat Fructus Jujubae etc., for China commonly uses rare Chinese medicine, applicating history is long; , tonifying YANG gentle with its benefit power and do not help fire, YIN nourishing and oiliness diaphragm, convergence and do not stay evil wait special efficacy like by successive dynasties medical science use.According to chemical analysis, Fructus Corni contains the effective ingredient such as the stronger cornin of physiologically active, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin, having and strengthen immunity, antiinflammatory, the pharmacological action such as antibacterial, is the Herba indigoferae Pseudotinctoriae commonly used in tcm clinical practice; (19) Radix Astragali has effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.Be used for the treatment of the deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.; (20) Folium Stevlae Rebaudianae has adjustment blood pressure, vessel softening, reduction blood fat, blood sugar lowering, glucose in urine, antibacterial hemostasis, analgesia, fat-reducing and beauty, YIN nourishing and the production of body fluid promoting, helps digest, and promotes the effects such as pancreas, spleen and stomach function and heat-clearing and toxic substances removing.
The invention provides a kind of herbal health care oral liquid of prevention and therapy diabetic retinopathy, it is advantageous that: one is the multiple Chinese herbal medicine of scientific compatibility, drug component, through dialectical compatibility, helps using mutually assistant, can effective prevention and therapy diabetic retinopathy; Two is the technique adopting " Ultrasonic Wave-Assisted Extraction+volatile matter distillation oil+decocting+alcohol extraction " in the preparation process of oral liquid, fully mixes the functional active components of the prevention and therapy diabetic retinopathy in Chinese herbal medicine, improves therapeutic effect; Three is that oral liquid has no side effect safely, drinks conveniently.
The invention provides a kind of herbal health care oral liquid of prevention and therapy diabetic retinopathy, carried out toxicology test and the safety evaluatio of health care oral liquid by animal experiment.Chmice acute Oral toxicity result of the test shows, this health care oral liquid is greater than high dose group 75mg/kgbw to chmice acute per os maximum tolerated dose; Genetic toxicity test mouse marrow cell micro nuclear test and mouse inbred strain two result of the tests are feminine gender, show that this health care oral liquid is without mutagenic action; From rat 30d feeding trial, the behavior of rat sign is normal, figure is healthy, blood and blood parameters also change without exception, and therefore the dosage (150 times of human body recommended amounts) of 75mg/kgbw belongs to safe dose; Genetic toxicity test and rat 30d feeding trial result are feminine gender, therefore determine that this health beverage belongs to non-toxic type food, and people can be safe relieved edible.
Detailed description of the invention
below in conjunction with embodiment, the present invention will be further described.
embodiment 1:
A herbal health care oral liquid for prevention and therapy diabetic retinopathy, prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to astaxanthin 8 parts, Concha Haliotidis 13 parts, Radix Rhodiolae 12 parts, Rhizoma Chuanxiong 12 parts, Radix Notoginseng 16 parts, 12 parts, Fructus Mori, Radix Paeoniae Rubra 10 parts, Fructus Schisandrae Chinensis 14 parts, Fructus Lycii 15 parts, Herba Epimedii 15 parts, Semen Cassiae 18 parts, Flos Chrysanthemi 12 parts, Radix Puerariae 15 parts, 12 parts, Radix Rehmanniae Preparata, Radix Angelicae Sinensis 10 parts, Herba Silybi mariani 7 parts, Cortex Moutan 8 parts, Fructus Corni 13 parts, the Radix Astragali 12 parts, Folium Stevlae Rebaudianae 13 parts of ratios in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after astaxanthin, Concha Haliotidis, Radix Rhodiolae, Rhizoma Chuanxiong, Radix Notoginseng, Radix Paeoniae Rubra, Fructus Schisandrae Chinensis, Herba Epimedii, Semen Cassiae, Flos Chrysanthemi, Radix Puerariae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Herba Silybi mariani, Cortex Moutan, Fructus Corni, the Radix Astragali, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. by Fructus Mori, Fructus Lycii mixing, add 2.5 times of pure water, making beating, then adds 1.5% pectase, enzymolysis 15min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 4 times of pure water after raw material mixing, then add raw materials quality than 2.5% cellulase, 1.5% non-starch polysaccharide enzyme, enzymolysis 45min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 4 times amount in Chinese herbal medicine residue, collect volatile oil 9h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.8% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2.5 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.8h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 5 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1.2h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.12% and the xylitol of 1.5%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 8min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
embodiment 2:
A herbal health care oral liquid for prevention and therapy diabetic retinopathy, prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to astaxanthin 10 parts, Concha Haliotidis 10 parts, Radix Rhodiolae 12 parts, Rhizoma Chuanxiong 10 parts, Radix Notoginseng 20 parts, 10 parts, Fructus Mori, Radix Paeoniae Rubra 12 parts, Fructus Schisandrae Chinensis 10 parts, Fructus Lycii 16 parts, Herba Epimedii 10 parts, Semen Cassiae 20 parts, Flos Chrysanthemi 10 parts, Radix Puerariae 18 parts, 10 parts, Radix Rehmanniae Preparata, Radix Angelicae Sinensis 12 parts, Herba Silybi mariani 5 parts, Cortex Moutan 10 parts, Fructus Corni 10 parts, the Radix Astragali 15 parts, Folium Stevlae Rebaudianae 10 parts of ratios in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after astaxanthin, Concha Haliotidis, Radix Rhodiolae, Rhizoma Chuanxiong, Radix Notoginseng, Radix Paeoniae Rubra, Fructus Schisandrae Chinensis, Herba Epimedii, Semen Cassiae, Flos Chrysanthemi, Radix Puerariae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Herba Silybi mariani, Cortex Moutan, Fructus Corni, the Radix Astragali, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. by Fructus Mori, Fructus Lycii mixing, add 3 times of pure water, making beating, then adds 2% pectase, enzymolysis 10min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 5 times of pure water after raw material mixing, then add raw materials quality than 3% cellulase, 2% non-starch polysaccharide enzyme, enzymolysis 30min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 5 times amount in Chinese herbal medicine residue, collect volatile oil 8h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 2.0% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 6 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.15% and the oligomeric isomaltose of 2%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
embodiment 3:
A herbal health care oral liquid for prevention and therapy diabetic retinopathy, prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to astaxanthin 5 parts, Concha Haliotidis 15 parts, Radix Rhodiolae 8 parts, Rhizoma Chuanxiong 15 parts, Radix Notoginseng 15 parts, 13 parts, Fructus Mori, Radix Paeoniae Rubra 8 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Lycii 10 parts, Herba Epimedii 18 parts, Semen Cassiae 15 parts, Flos Chrysanthemi 15 parts, Radix Puerariae 12 parts, 15 parts, Radix Rehmanniae Preparata, Radix Angelicae Sinensis 8 parts, Herba Silybi mariani 10 parts, Cortex Moutan 5 parts, Fructus Corni 15 parts, the Radix Astragali 10 parts, Folium Stevlae Rebaudianae 15 parts of ratios in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after astaxanthin, Concha Haliotidis, Radix Rhodiolae, Rhizoma Chuanxiong, Radix Notoginseng, Radix Paeoniae Rubra, Fructus Schisandrae Chinensis, Herba Epimedii, Semen Cassiae, Flos Chrysanthemi, Radix Puerariae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Herba Silybi mariani, Cortex Moutan, Fructus Corni, the Radix Astragali, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. by Fructus Mori, Fructus Lycii mixing, add 2 times of pure water, making beating, then adds 1% pectase, enzymolysis 20min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 3 times of pure water after raw material mixing, then add raw materials quality than 2% cellulase, 1% non-starch polysaccharide enzyme, enzymolysis 60min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 3 times amount in Chinese herbal medicine residue, collect volatile oil 10h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.5% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 2h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 4 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1.5h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.10% and the Mel of 1%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 5 ~ 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
The invention provides a kind of herbal health care oral liquid of prevention and therapy diabetic retinopathy, different Chinese herbal medicine nature and flavor are different, effect also exists huge difference, complicated interaction relationship is there is after different Chinese herbal medicine combinations, and proportioning between Chinese herbal medicine is closer, different ratio also will make monarch relation that substantial change occurs, thus make the relation generation material alterations of composite Chinese herbal.The application passes through astaxanthin, Concha Haliotidis, Radix Rhodiolae, Rhizoma Chuanxiong, Radix Notoginseng, Fructus Mori, Radix Paeoniae Rubra, Fructus Schisandrae Chinensis, Fructus Lycii, Herba Epimedii, Semen Cassiae, Flos Chrysanthemi, Radix Puerariae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Herba Silybi mariani, Cortex Moutan, Fructus Corni, the Radix Astragali, there is complicated interaction relationship to each other in the Chinese herbal medicine such as Folium Stevlae Rebaudianae, rational proportion, achieve unforeseeable technique effect, make the relation generation material alterations of prevention and therapy diabetic retinopathy herbal health care oral liquid, the total antioxidant capacity of the application's herbal health care oral liquid reaches 523.116 ± 47.84U/mL, change Chinese herbal medicine proportioning or Chinese herbal medicine composition can reduce the oxidation resistance of health care oral liquid.Carried out Evaluation of Functional according to " function of health food assessment process and the method for inspection " to the application's product, adopt Spontaneous type Ⅱ diabetes KK/Upj-Ay mouse model, relative analysis product of the present invention is to diabetic retina protective effect.Result of the test shows: after gastric infusion, product of the present invention can significantly reduce blood glucose and glycolated hemoglobin, light microscopic and the remarkable product of the present invention of Electronic Speculum result can delay the appearance of diabetic mice retinopathy, and there is good therapeutic efficiency, difference is extremely significantly (p<0.01) compared with model group, photograph group; Evaluate with the prevention and therapy diabetic retinopathy of the method contrasted between self and group to product, at random 50 Patients With Diabetic Retinopathies are divided into test group and matched group, after taking 30h continuously, the apparition of test group retinopathy alleviates, total effective rate more than 93.33%, before and after experiment, blood, urine, feces routine examination and blood biochemistry test rating are all normal, demonstrate effect that product of the present invention has good prevention and therapy diabetic retinopathy.In addition, result of the test shows, changes marine active substance and the composition of Chinese herbal medicine and effect of reduction product more remarkable in regular meeting, and result difference significantly (p<0.05).
Above embodiment only for illustration of technical scheme of the present invention, but not is limited; Although be described in detail by invention with reference to previous embodiment, for the person of ordinary skill of the art, still the technical scheme described in previous embodiment can be modified, or equivalent replacement has been carried out to wherein portion of techniques feature; And to these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of the present invention's technical scheme required for protection.
Claims (2)
1. a herbal health care oral liquid for prevention and therapy diabetic retinopathy, is characterized in that preparation technology comprises the following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., according to astaxanthin 5 ~ 10 parts in every 1000 portions of oral liquids, Concha Haliotidis 10 ~ 15 parts, Radix Rhodiolae 8 ~ 12 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Radix Notoginseng 15 ~ 20 parts, 10 ~ 13 parts, Fructus Mori, Radix Paeoniae Rubra 8 ~ 12 parts, Fructus Schisandrae Chinensis 10 ~ 15 parts, Fructus Lycii 10 ~ 16 parts, Herba Epimedii 10 ~ 18 parts, Semen Cassiae 15 ~ 20 parts, Flos Chrysanthemi 10 ~ 15 parts, Radix Puerariae 12 ~ 18 parts, 10 ~ 15 parts, Radix Rehmanniae Preparata, Radix Angelicae Sinensis 8 ~ 12 parts, Herba Silybi mariani 5 ~ 10 parts, Cortex Moutan 5 ~ 10 parts, Fructus Corni 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Folium Stevlae Rebaudianae 10 ~ 15 parts of ratios are weighed,
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after astaxanthin, Concha Haliotidis, Radix Rhodiolae, Rhizoma Chuanxiong, Radix Notoginseng, Radix Paeoniae Rubra, Fructus Schisandrae Chinensis, Herba Epimedii, Semen Cassiae, Flos Chrysanthemi, Radix Puerariae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Herba Silybi mariani, Cortex Moutan, Fructus Corni, the Radix Astragali, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. by Fructus Mori, Fructus Lycii mixing, add 2 ~ 3 times of pure water, making beating, then adds 1 ~ 2% pectase, enzymolysis 10 ~ 20min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 3 ~ 5 times of pure water after raw material mixing, then raw materials quality is added than 2 ~ 3% cellulase, 1 ~ 2% non-starch polysaccharide enzyme, enzymolysis 30 ~ 60min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 3 ~ 5 times amount in Chinese herbal medicine residue, collect volatile oil 8 ~ 10h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.5 ~ 2.0% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2 ~ 3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5 ~ 2h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 4 ~ 6 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1 ~ 1.5h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.10 ~ 0.15% and the sweeting agent of 1 ~ 2%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 5 ~ 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
2. the herbal health care oral liquid of a kind of prevention and therapy diabetic retinopathy according to claim 1, what it is characterized in that described sweeting agent selects is the mixture of one or more in xylitol, oligomeric isomaltose, Mel.
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| CN111012818A (en) * | 2020-01-07 | 2020-04-17 | 佛山科学技术学院 | Myopia-preventing capsule and preparation method thereof |
| US11696593B2 (en) | 2018-08-24 | 2023-07-11 | Bioscience Formulators, LLC | Astaxanthin nutritional compositions and uses |
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Cited By (3)
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| US11696593B2 (en) | 2018-08-24 | 2023-07-11 | Bioscience Formulators, LLC | Astaxanthin nutritional compositions and uses |
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