CN104547534B - A kind of herbal health care oral solution with efficacy of relieving visual fatigue - Google Patents
A kind of herbal health care oral solution with efficacy of relieving visual fatigue Download PDFInfo
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Abstract
The invention discloses a kind of herbal health care oral solutions with efficacy of relieving visual fatigue,The products material formula is that the herbal raw material composition of 1000 parts of health care oral liquids is 5~10 parts of ginseng,10~15 parts of Semen Cuscutae,8~12 parts of rhodiola root,10~15 parts of the fleece-flower root,15~20 parts of wilsonii,10~13 parts of mulberry fruit,8~12 parts of Radix Rehmanniae,10~15 parts of Radix Ophiopogonis,10~16 parts of matrimony vine,10~18 parts of Herba Epimedii,15~20 parts of cassia seed,10~15 parts of chrysanthemum,12~18 parts of honeysuckle,10~15 parts of cordate houttuynia,8~12 parts of Radix Angelicae Sinensis,5~10 parts of milk thistle,5~10 parts of mulberry leaf,10~15 parts of the fruit of glossy privet,10~15 parts of Rhizoma Atractylodis Macrocephalae,10~15 parts of STEVIA REBAUDIANA,It is prepared using " Ultrasonic Wave-Assisted Extraction+volatile matter distillation oil+decocting+alcohol extracting " technique.The product has that efficacy of relieving visual fatigue is good, safety is without side-effects, drinks and the advantages such as facilitates.
Description
Technical field
The present invention relates to a kind of herbal health care oral solutions with efficacy of relieving visual fatigue, and especially one kind is in plant
Herbal medicine is health care oral liquid made of raw material, belongs to herbal health care field.
Background technology
Visual fatigue is also known as asthenopia, former describing the noun with the relevant a series of symptoms of excess eye-using.Because of its generation
Reason complexity is various, and most scholars think that the generation of visual fatigue is that eye or whole body apparatus factors are mutually handed over psychologic factors
The result to be formed is knitted, belongs to psychosomatics scope, but eye symptom is usually felt as outstanding behaviours, therefore, in clinic using patient
Upper frequently referred to asthenopia syndrome again.According to clinical investigation, excessive and light-source brightness is not correctly corrected and adjusted to dioptric not
Fully, it is the main reason for generating visual fatigue that ambient brightness is uneven etc..When will produce headache, dizzy under visual fatigue serious conditions
It is dizzy, induce the symptoms such as stomach dysfunction, spasm of ocular muscles, whole body be uncomfortable, especially with a large amount of general of the video terminals such as computer
And the incidence of visual fatigue is made to be in the trend being gradually increasing.Therefore, the Crack cause of visual fatigue, pathogenesis and prevention are more next
More obtain the concern of people.
Chinese herbal medicine is the rarity of Chinese traditional culture, and with stepping up for people's lives, the health care consciousness of people is gradual
Enhancing increasingly increases in the demand for alleviating visual fatigue, pre- myopia prevention etc., and Chinese herbal medicine is in the field health food development process
In in occupation of innate advantage condition.For the Chinese herbal medicine culture for passing on of long standing and well established, meet the needs of people is to health care, this hair
It is bright to choose the Chinese herbal medicine there is tonifying Qi help, strengthen the body resistance to consolidate the constitution and other effects, develop the Chinese herbal medicine with efficacy of relieving visual fatigue
Health care oral liquid.
Invention content
To overcome the shortcomings of existing alleviation visual fatigue product technology, the purpose of the present invention is to provide one kind, and there is alleviation to regard
Fatigue prevents the herbal health care oral solution evil that vision endangers health-care efficacy.
Above-mentioned purpose of the present invention is achieved by the following technical programs：
The present invention provides a kind of herbal health care oral solution with efficacy of relieving visual fatigue, it is characterised in that：1000 parts
Chinese medicine material and quality proportioning are in oral solution：5~10 parts of ginseng, 10~15 parts of Semen Cuscutae, 8~12 parts of rhodiola root, the fleece-flower root
10~15 parts, it is 15~20 parts of wilsonii, 10~13 parts of mulberry fruit, 8~12 parts of Radix Rehmanniae, 10~15 parts of Radix Ophiopogonis, 10~16 parts of matrimony vine, excessive
10~18 parts of the sheep leaves of pulse plants, 15~20 parts of cassia seed, 10~15 parts of chrysanthemum, 12~18 parts of honeysuckle, 10~15 parts of cordate houttuynia, Radix Angelicae Sinensis 8
~12 parts, 5~10 parts of milk thistle, 5~10 parts of mulberry leaf, 10~15 parts of the fruit of glossy privet, 10~15 parts of Rhizoma Atractylodis Macrocephalae, 10~15 parts of STEVIA REBAUDIANA.
The preferred technical solution of the present invention is：A kind of herbal health care oral solution with efficacy of relieving visual fatigue, it is special
Sign is：Its Chinese medicine material and quality proportioning are：8 parts of ginseng, 13 parts of Semen Cuscutae, 12 parts of rhodiola root, 12 parts of the fleece-flower root, wilsonii
16 parts, 12 parts of mulberry fruit, 10 parts of Radix Rehmanniae, 14 parts of Radix Ophiopogonis, 15 parts of matrimony vine, 15 parts of Herba Epimedii, 18 parts of cassia seed, 12 parts of chrysanthemum, gold and silver
Spend 15 parts, 12 parts of cordate houttuynia, 10 parts of Radix Angelicae Sinensis, 7 parts of milk thistle, 8 parts of mulberry leaf, 13 parts of the fruit of glossy privet, 12 parts of Rhizoma Atractylodis Macrocephalae, 13 parts of STEVIA REBAUDIANA.
The present invention provides a kind of herbal health care oral solution with efficacy of relieving visual fatigue, it is characterised in that by following
It is prepared by step：
（1）Sorting weighs：Chinese herbal medicine used is sorted, removal impurity etc. is weighed according to aforementioned proportion；
（2）Pretreatment of raw material：Pretreatment of raw material is carried out respectively according to property of raw material difference：
1. by ginseng, Semen Cuscutae, rhodiola root, the fleece-flower root, wilsonii, Radix Rehmanniae, Radix Ophiopogonis, Herba Epimedii, cassia seed, chrysanthemum, gold
Pulverization process is carried out after honeysuckle flower, cordate houttuynia, Radix Angelicae Sinensis, milk thistle, mulberry leaf, the fruit of glossy privet, Rhizoma Atractylodis Macrocephalae, STEVIA REBAUDIANA mixing, crosses 40 mesh sieve；
2. mulberry fruit, matrimony vine are mixed, 2~3 times of pure water are added, then 1~2% pectase is added, 40~50 in mashing
10~20min is digested under the conditions of DEG C；
（3）Ultrasound-assisted enzymolysis：Than 3~5 times pure water of material quality are added after raw material mixing, raw material matter is then added
Amount digests 30~60min, hydrolysis temperature than 2~3% cellulases, 1~2% non-starch polysaccharide enzyme under ultrasonic wave subsidiary conditions
Control is at 40~50 DEG C；
（4）Centrifugation：Centrifuge leaching liquor and middle medicinal herbs residue；
（5）Distillation：The pure water of 3~5 times of amounts is added into Chinese herbal medicine residue, collects 8~10h of volatile oil, volatile oil list
It solely collects and places, aqueous solution filtering merges with leaching liquor；
（6）Volatile oil emulsifies：1.5~2.0% cosolvent Tween-80, heating emulsification will be added in the volatile oil of collection；
（7）Decocting：The water of 2~3 times of amounts will be added in Chinese herbal medicine residue after distillation, decoct 3 times, every time 1.5~2h, water
Decocting liquid merges with leaching liquor；
（8）It is concentrated under reduced pressure：Aqueous solution after merging is concentrated into the clear cream of 1g/ml, is let cool；
（9）Alcohol precipitation：48h or more is placed under the conditions of the ethyl alcohol of addition 95% makes alcohol content reach 60~70%, 4 DEG C into clear cream
（10）Alcohol extracting：50% ethyl alcohol of 4~6 times of amounts, heating extraction 2 times, extraction are added into the Chinese herbal medicine residue after decocting
1~1.5h of time；
（11）Merge and filters：Liquid after alcohol precipitation is merged into suction filtration with alcohol extract；
（12）It is recovered under reduced pressure：Smoke filtrate be recovered under reduced pressure ethyl alcohol to no alcohol taste；
（13）Mixing：The volatile oil emulsified is added into concentrate while hot, stirs evenly；
（14）Add auxiliary material：0.10~0.15% potassium sorbate and 1~2% sweetener is added, water is added to stir constant volume；
（15）It stands：48h or more will be stood under oral solution semi-finished product room temperature；
（16）Centrifugation：Oral solution semi-finished product 3000r/min is centrifuged into 5~10min；
（17）Constant volume dispenses：By after centrifugation oral solution constant volume, dispense up to oral solution finished product.
What above-mentioned sweetener was selected is the mixture of one or more of xylitol, oligoisomaltose, honey.
Pharmaceutical composition is the selected prescription under Traditional Chinese medical theory and practical advice in the present invention.Chinese medicine composition of the present invention
In：Ginseng has the effect of " tonifying five zang organs, soothe the nerves determine soul, stop palpitate with fear, remove pathogenic factor, happy intelligence development tomorrow ", and " long term usage, which is made light of one's life by commiting suicide, prolongs
Year ", ginseng is all listed in top grade in Chinese herbal medicine for thousands of years；Semen Cuscutae smell is pungent, and sweet and neutral is nontoxic, cures mainly tonifying kidney and benefiting sperm, nourishing the liver
Improving eyesight, the waist and knee muscles and bones suitable for kidney deficiency and liver are ached, and legs and feet are weak and feeble, impotence and seminal emission, crazy talk, frequent urination, urine are had a surplus
Drip, dizzy, blurring of vision, Hiccough and deaf and women are under, the diseases such as habitual abortion；Rhodiola root can improve sleep, life
Blood promoting blood circulation, antifatigue, promoting blood circulation and hemostasis, removing heat from the lung to relieve cough, changes detumescence of becoming silted up, antipyretic bring down a fever, nourishes vigour and other effects anti-cerebral anoxia；What
The tuber of multiflower knotweed, which has, promotes hematopoiesis function, improves body's immunity, reducing blood lipid, antiatherosclerosis, liver protection, anti-aging, shadow
Endocrine function is rung, relax bowel and other effects；There is wilsonii adjusting body disorder to be allowed to tend to normal function, have good
Antifatigue effect, notable compared with ginseng, bowl spares strengthening the essence, strong will, wind-damp dispelling, strengthens the bone, blood circulation and promoting silt, the functions such as stomach invigorating diuresis,
Long term usage " makes light of one's life by commiting suicide and endures hardships "；Mulberry fruit contains abundant activated protein, provitamin A, B1、B2, PP and C, amino acid, malic acid, amber
The ingredients such as amber acid, tartaric acid, carrotene, mineral calcium, phosphorus, iron, copper, zinc, with improve the immunity of the human body with slow down aging
The multiple efficacies such as beautifying face and moistering lotion are described as " the best health fruit of 21st century " by medical field；Radix Rehmanniae have heat-clearing, promote the production of body fluid,
It moisturizes, laxation, broken stasis of blood, give birth to new, analgesic, menstruation regulating, the metal-inflicted wound stasis of blood, cool blood, hemostasis and other effects；Radix Ophiopogonis property is sweet, slight bitter, cool, enriching yin life
Tianjin is moistened the lung and relieve the cough, relieving restlessness that clears away heart-fire.Cure mainly consumption of body fluid caused by febrile disease, vexed, thirsty, dry throat lung heat, cough, pulmonary tuberculosis；Matrimony vine is rare
Medicinal material and invigorant, Chinese medicine have the saying of " medlar health preserving " very early《Compendium of Materia Medica》It records：" matrimony vine, kidney-tonifying sperm-generating are supported
Liver ... improving eyesight is calmed the nerves, and makes us long-lived, has nourishing the liver, nourshing kidney, moistening lung and other effects；Herba Epimedii has kidney-replenishing, strengthening the bones and muscles, wind-dispelling
It is wet and other effects；Cassia seed has the function of clearing liver and improving vision, defaecation, cures mainly hypertension, headache, dizziness, acute conjunctivitis, cornea are burst
The diseases such as ulcer, glaucoma, carbuncle furuncle sore；Chrysanthemum is sweet, is slightly cold, and has effects that dissipate wind-heat, flat liver improving eyesight, the cough that disappears analgesic, is used for
The illnesss significant effects such as dizziness of having a headache, red eye, swell pain, anemopyretic cold, cough are treated, also have effects that refresh the mind；Honeysuckle
The necessary trace element of honeysuckle human body containing there are many and chemical composition, while containing there are many to the advantageous organized enzyme object of human body
Matter has anti-aging, anti-canceration, the good effects being healthy and strong of making light of one's life by commiting suicide；Cordate houttuynia, which has to alleviate visual fatigue effect and enhance body, exempts from
The effect of epidemic disease function, and it is without any side effects, it is suitable for the personnel often close to radiation source, such as X-ray machine and computation people
Member, and often see the crowd of TV；The radiation protection food that computer family must eat；Radix Angelicae Sinensis has replenishing and activating blood, menstruction regulating and pain relieving, ease constipation
Defaecation and other effects, for blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, rheumatism numbness
Bitterly, injury from falling down, ulcer sores；Milk thistle has clearing heat and detoxicating, liver protection, cholagogic, protects brain, anti-X-ray and other effects；Mulberry leaf have
Blood pressure lowering, blood fat, it is anti-inflammatory the effects that, major function is dispelling wind and heat from the body, and clearing away the lungheat and moisturizing is clear liver and improved vision, be used for anemopyretic cold, lung heat
Cough caused by dryness, dizziness headache, hot eyes are dim-sighted；Fruit of glossy privet sweet, bitter, cold, major function is nourishing liver and kidney, improving eyesight black hair, is used for dizziness ear
Ring, soreness and weakness of waist and knees, poliosis, mesh are secretly unknown；Rhizoma Atractylodis Macrocephalae has strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, tocolysis and other effects, is used for
Spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability.
The selected Chinese herbal medicine formula of the present invention, drug component are helped through dialectical compatibility using mutually to help, can prevent because
Visual fatigue caused by excess eye-using；It can prevent to impact vision system due to excessively high electromagnetic radiation, it can be pre- anti-electric
Visual impairment caused by magnetic radiation, xerophthalmia, cataract etc..
The present invention provides a kind of herbal health care oral solution with efficacy of relieving visual fatigue, it is advantageous that：First, section
The a variety of Chinese herbal medicines of compatibility are learned, visual fatigue can be effectively relieved；Second is that using " Ultrasonic Wave-Assisted Extraction in the preparation process of oral solution
The technique of+volatile matter distillation oil+decocting+alcohol extracting " is fully mixed the functional active components of the alleviation visual fatigue in Chinese herbal medicine, is improved
Therapeutic effect；Third, oral solution is without side-effects safely, drink conveniently.
The present invention provides a kind of herbal health care oral solution for alleviating visual fatigue, and health care oral liquid is carried out by animal experiment
Toxicology test and safety evaluatio.Chmice acute Oral toxicity test result shows this health care oral liquid to chmice acute
Oral maximum tolerated dose is more than high dose group 75mg/kgbw；Genetic toxicity test mouse marrow cell micro nuclear test and small
Two test results of mouse sperm malformation test are feminine gender, show the health care oral liquid without mutagenesis；It is fed by rat 30d
Experiment is it is found that rat sign behavior is normal, figure is healthy, blood and blood parameters also variation without exception, therefore 75mg/
The dosage of kgbw（150 times of human body recommended amounts）Belong to safe dose；Genetic toxicity test and rat 30d feeding trial results
It is feminine gender, it is thus determined that this health drink belongs to nontoxic based food, people can be edible with safe and secure.
Specific implementation mode
With reference to embodiment, the present invention will be further described.
Embodiment 1：
A kind of herbal health care oral solution with efficacy of relieving visual fatigue, is prepared by following steps：
（1）Sorting weighs：Chinese herbal medicine used is sorted, removal impurity etc., according to 8 parts of ginseng in every 1000 portions of oral solutions,
13 parts of Semen Cuscutae, 12 parts of rhodiola root, 12 parts of the fleece-flower root, 16 parts of wilsonii, 12 parts of mulberry fruit, 10 parts of Radix Rehmanniae, 14 parts of Radix Ophiopogonis, matrimony vine 15
Part, 15 parts of Herba Epimedii, 18 parts of cassia seed, 12 parts of chrysanthemum, 15 parts of honeysuckle, 12 parts of cordate houttuynia, 10 parts of Radix Angelicae Sinensis, 7 parts of milk thistle, mulberry
13 parts of 8 parts of leaf, 13 parts of the fruit of glossy privet, 12 parts of Rhizoma Atractylodis Macrocephalae, STEVIA REBAUDIANA ratios are weighed；
（2）Pretreatment of raw material：Pretreatment of raw material is carried out respectively according to property of raw material difference：
1. by ginseng, Semen Cuscutae, rhodiola root, the fleece-flower root, wilsonii, Radix Rehmanniae, Radix Ophiopogonis, Herba Epimedii, cassia seed, chrysanthemum, gold
Pulverization process is carried out after honeysuckle flower, cordate houttuynia, Radix Angelicae Sinensis, milk thistle, mulberry leaf, the fruit of glossy privet, Rhizoma Atractylodis Macrocephalae, STEVIA REBAUDIANA mixing, crosses 40 mesh sieve；
2. mulberry fruit, matrimony vine are mixed, 2.5 times of pure water are added, then 1.5% pectase is added, at 40~50 DEG C in mashing
Under the conditions of digest 15min；
（3）Ultrasound-assisted enzymolysis：Than 4 times pure water of material quality are added after raw material mixing, material quality is then added
Than 2.5% cellulase, 1.5% non-starch polysaccharide enzyme, 45min is digested under ultrasonic wave subsidiary conditions, hydrolysis temperature is controlled 40
~50 DEG C；
（4）Centrifugation：Centrifuge leaching liquor and middle medicinal herbs residue；
（5）Distillation：The pure water of 4 times of amounts is added into Chinese herbal medicine residue, collects volatile oil 9h, volatile oil, which is collected separately, to be put
It sets, aqueous solution filtering merges with leaching liquor；
（6）Volatile oil emulsifies：1.8% cosolvent Tween-80, heating emulsification will be added in the volatile oil of collection；
（7）Decocting：The water of 2.5 times of amounts will be added in Chinese herbal medicine residue after distillation, decocts 3 times, each 1.8h, decocting liquid
Merge with leaching liquor；
（8）It is concentrated under reduced pressure：Aqueous solution after merging is concentrated into the clear cream of 1g/ml, is let cool；
（9）Alcohol precipitation：48h or more is placed under the conditions of the ethyl alcohol of addition 95% makes alcohol content reach 60~70%, 4 DEG C into clear cream
（10）Alcohol extracting：50% ethyl alcohol of 5 times of amounts, heating extraction 2 times, when extraction are added into the Chinese herbal medicine residue after decocting
Between 1.2h；
（11）Merge and filters：Liquid after alcohol precipitation is merged into suction filtration with alcohol extract；
（12）It is recovered under reduced pressure：Smoke filtrate be recovered under reduced pressure ethyl alcohol to no alcohol taste；
（13）Mixing：The volatile oil emulsified is added into concentrate while hot, stirs evenly；
（14）Add auxiliary material：0.12% potassium sorbate and 1.5% xylitol is added, water is added to stir constant volume；
（15）It stands：48h or more will be stood under oral solution semi-finished product room temperature；
（16）Centrifugation：Oral solution semi-finished product 3000r/min is centrifuged into 8min；
（17）Constant volume dispenses：By after centrifugation oral solution constant volume, dispense up to oral solution finished product.
Embodiment 2：
A kind of herbal health care oral solution with efficacy of relieving visual fatigue, is prepared by following steps：
（1）Sorting weighs：Chinese herbal medicine used is sorted, removal impurity etc., according to 10 parts of ginseng in every 1000 portions of oral solutions,
10 parts of Semen Cuscutae, 12 parts of rhodiola root, 10 parts of the fleece-flower root, 20 parts of wilsonii, 10 parts of mulberry fruit, 12 parts of Radix Rehmanniae, 10 parts of Radix Ophiopogonis, matrimony vine 16
Part, 10 parts of Herba Epimedii, 20 parts of cassia seed, 10 parts of chrysanthemum, 18 parts of honeysuckle, 10 parts of cordate houttuynia, 12 parts of Radix Angelicae Sinensis, 5 parts of milk thistle, mulberry
10 parts of 10 parts of leaf, 10 parts of the fruit of glossy privet, 15 parts of Rhizoma Atractylodis Macrocephalae, STEVIA REBAUDIANA ratios are weighed；
（2）Pretreatment of raw material：Pretreatment of raw material is carried out respectively according to property of raw material difference：
1. by ginseng, Semen Cuscutae, rhodiola root, the fleece-flower root, wilsonii, Radix Rehmanniae, Radix Ophiopogonis, Herba Epimedii, cassia seed, chrysanthemum, gold
Pulverization process is carried out after honeysuckle flower, cordate houttuynia, Radix Angelicae Sinensis, milk thistle, mulberry leaf, the fruit of glossy privet, Rhizoma Atractylodis Macrocephalae, STEVIA REBAUDIANA mixing, crosses 40 mesh sieve；
2. mulberry fruit, matrimony vine are mixed, 3 times of pure water are added, then 2% pectase is added, in 40~50 DEG C of conditions in mashing
Lower enzymolysis 10min；
（3）Ultrasound-assisted enzymolysis：Than 5 times pure water of material quality are added after raw material mixing, material quality is then added
Than 3% cellulase, 2% non-starch polysaccharide enzyme, 30min is digested under ultrasonic wave subsidiary conditions, hydrolysis temperature is controlled 40~50
℃；
（4）Centrifugation：Centrifuge leaching liquor and middle medicinal herbs residue；
（5）Distillation：The pure water of 5 times of amounts is added into Chinese herbal medicine residue, collects volatile oil 8h, volatile oil, which is collected separately, to be put
It sets, aqueous solution filtering merges with leaching liquor；
（6）Volatile oil emulsifies：2.0% cosolvent Tween-80, heating emulsification will be added in the volatile oil of collection；
（7）Decocting：Will in the Chinese herbal medicine residue after distillation be added 3 times amount water, decoct 3 times, each 1.5h, decocting liquid with
Leaching liquor merges；
（8）It is concentrated under reduced pressure：Aqueous solution after merging is concentrated into the clear cream of 1g/ml, is let cool；
（9）Alcohol precipitation：48h or more is placed under the conditions of the ethyl alcohol of addition 95% makes alcohol content reach 60~70%, 4 DEG C into clear cream
（10）Alcohol extracting：50% ethyl alcohol of 6 times of amounts, heating extraction 2 times, when extraction are added into the Chinese herbal medicine residue after decocting
Between 1h；
（11）Merge and filters：Liquid after alcohol precipitation is merged into suction filtration with alcohol extract；
（12）It is recovered under reduced pressure：Smoke filtrate be recovered under reduced pressure ethyl alcohol to no alcohol taste；
（13）Mixing：The volatile oil emulsified is added into concentrate while hot, stirs evenly；
（14）Add auxiliary material：0.15% potassium sorbate and 2% oligoisomaltose is added, water is added to stir constant volume；
（15）It stands：48h or more will be stood under oral solution semi-finished product room temperature；
（16）Centrifugation：Oral solution semi-finished product 3000r/min is centrifuged into 10min；
（17）Constant volume dispenses：By after centrifugation oral solution constant volume, dispense up to oral solution finished product.
Embodiment 3：
A kind of herbal health care oral solution with efficacy of relieving visual fatigue, is prepared by following steps：
（1）Sorting weighs：Chinese herbal medicine used is sorted, removal impurity etc., according to 5 parts of ginseng in every 1000 portions of oral solutions,
15 parts of Semen Cuscutae, 8 parts of rhodiola root, 15 parts of the fleece-flower root, 15 parts of wilsonii, 13 parts of mulberry fruit, 8 parts of Radix Rehmanniae, 15 parts of Radix Ophiopogonis, matrimony vine 10
Part, 18 parts of Herba Epimedii, 15 parts of cassia seed, 15 parts of chrysanthemum, 12 parts of honeysuckle, 15 parts of cordate houttuynia, 8 parts of Radix Angelicae Sinensis, 10 parts of milk thistle, mulberry
15 parts of 5 parts of leaf, 15 parts of the fruit of glossy privet, 10 parts of Rhizoma Atractylodis Macrocephalae, STEVIA REBAUDIANA ratios are weighed；
（2）Pretreatment of raw material：Pretreatment of raw material is carried out respectively according to property of raw material difference：
1. by ginseng, Semen Cuscutae, rhodiola root, the fleece-flower root, wilsonii, Radix Rehmanniae, Radix Ophiopogonis, Herba Epimedii, cassia seed, chrysanthemum, gold
Pulverization process is carried out after honeysuckle flower, cordate houttuynia, Radix Angelicae Sinensis, milk thistle, mulberry leaf, the fruit of glossy privet, Rhizoma Atractylodis Macrocephalae, STEVIA REBAUDIANA mixing, crosses 40 mesh sieve；
2. mulberry fruit, matrimony vine are mixed, 2 times of pure water are added, then 1% pectase is added, in 40~50 DEG C of conditions in mashing
Lower enzymolysis 20min；
（3）Ultrasound-assisted enzymolysis：Than 3 times pure water of material quality are added after raw material mixing, material quality is then added
Than 2% cellulase, 1% non-starch polysaccharide enzyme, 60min is digested under ultrasonic wave subsidiary conditions, hydrolysis temperature is controlled 40~50
℃；
（4）Centrifugation：Centrifuge leaching liquor and middle medicinal herbs residue；
（5）Distillation：The pure water of 3 times of amounts is added into Chinese herbal medicine residue, collects volatile oil 10h, volatile oil is collected separately
It places, aqueous solution filtering merges with leaching liquor；
（6）Volatile oil emulsifies：1.5% cosolvent Tween-80, heating emulsification will be added in the volatile oil of collection；
（7）Decocting：The water of 2 times of amounts will be added in Chinese herbal medicine residue after distillation, decocts 3 times, each 2h, decocting liquid and leaching
Extract merges；
（8）It is concentrated under reduced pressure：Aqueous solution after merging is concentrated into the clear cream of 1g/ml, is let cool；
（9）Alcohol precipitation：48h or more is placed under the conditions of the ethyl alcohol of addition 95% makes alcohol content reach 60~70%, 4 DEG C into clear cream
（10）Alcohol extracting：50% ethyl alcohol of 4 times of amounts, heating extraction 2 times, when extraction are added into the Chinese herbal medicine residue after decocting
Between 1.5h；
（11）Merge and filters：Liquid after alcohol precipitation is merged into suction filtration with alcohol extract；
（12）It is recovered under reduced pressure：Smoke filtrate be recovered under reduced pressure ethyl alcohol to no alcohol taste；
（13）Mixing：The volatile oil emulsified is added into concentrate while hot, stirs evenly；
（14）Add auxiliary material：0.10% potassium sorbate and 1% honey is added, water is added to stir constant volume；
（15）It stands：48h or more will be stood under oral solution semi-finished product room temperature；
（16）Centrifugation：Oral solution semi-finished product 3000r/min is centrifuged into 5~10min；
（17）Constant volume dispenses：By after centrifugation oral solution constant volume, dispense up to oral solution finished product.
The present invention provides a kind of herbal health care oral solution for alleviating visual fatigue, and different Chinese herbal medicine nature and flavor are different, effect
There is huge difference, there is complicated interaction relationship, and the proportioning between Chinese herbal medicine after the combination of different Chinese herbal medicines
Compare closely, different ratio also will make monarch relationship that substantive variation occur, to make the relationship of composite Chinese herbal send out
Raw material alterations.The application by ginseng, Semen Cuscutae, rhodiola root, the fleece-flower root, wilsonii, mulberry fruit, Radix Rehmanniae, Radix Ophiopogonis, matrimony vine,
The Chinese herbal medicines such as Herba Epimedii, cassia seed, chrysanthemum, honeysuckle, cordate houttuynia, Radix Angelicae Sinensis, milk thistle, mulberry leaf, the fruit of glossy privet, Rhizoma Atractylodis Macrocephalae, STEVIA REBAUDIANA
There is complicated interaction relationship to each other, rational proportion achieves unexpected technique effect, makes in alleviation visual fatigue
Material alterations occur for the relationship of herb health oral solution, and the total antioxidant capacity of the application herbal health care oral solution reaches
485.36 ± 23.47U/mL, the oxidation resistance of health care oral liquid can be reduced by changing Chinese herbal medicine proportioning or Chinese herbal medicine composition.According to
《Function of health food assessment process and the method for inspection》Evaluation of Functional is carried out to the application product, the results showed that test group
Mouse bone cell micronucleus rate significantly reduces, and peripheral cells number and Quantity of DNA obviously increase, poor compared with the control group
It is different significantly, it was demonstrated that product of the present invention has certain protective effect to radiation hazradial bundle；With the method pair compareed between itself and group
The efficacy of relieving visual fatigue of product is evaluated, and 50 asthenopes are divided into test group and control group at random, continuously take 30h
Afterwards, the sense of test group visual fatigue is substantially reduced, and duration of photopic vision averagely improves 24.17% or more, 94% or more total effective rate, before experiment
Afterwards blood, urine, feces routine inspection and blood biochemistry test rating are normal, it was demonstrated that product of the present invention, which has, preferable alleviates visual fatigue
The effect of.
Above example is only used to illustrate the technical scheme of the present invention, rather than is limited；Although with reference to aforementioned reality
Example is applied to being described in detail by invention, but for those of ordinary skill in the art, it still can be to aforementioned reality
The technical solution recorded in example is applied to modify or equivalent replacement of some of the technical features；And to these modifications
Or it replaces, the spirit and scope for claimed technical solution of the invention that it does not separate the essence of the corresponding technical solution.
Claims (2)
1. a kind of application of Chinese medicine composition in preparing the herbal health care oral solution with efficacy of relieving visual fatigue, feature
It is, Chinese medicine composition and quality proportioning are：5~10 parts of ginseng, 10~15 parts of Semen Cuscutae, 8~12 parts of rhodiola root, the fleece-flower root 10
~15 parts, 15~20 parts of wilsonii, 10~13 parts of mulberry fruit, 8~12 parts of Radix Rehmanniae, 10~15 parts of Radix Ophiopogonis, 10~16 parts of matrimony vine, excessive sheep
10~18 parts of the leaves of pulse plants, 15~20 parts of cassia seed, 10~15 parts of chrysanthemum, 12~18 parts of honeysuckle, 10~15 parts of cordate houttuynia, Radix Angelicae Sinensis 8~
12 parts, 5~10 parts of milk thistle, 5~10 parts of mulberry leaf, 10~15 parts of the fruit of glossy privet, 10~15 parts of Rhizoma Atractylodis Macrocephalae, 10~15 parts of STEVIA REBAUDIANA；
The preparation process of herbal health care oral solution includes the following steps：
（1）Sorting weighs：Chinese herbal medicine used is sorted, impurity is removed, according to 5~10 parts of ginseng, Tu in every 1000 portions of oral solutions
10~15 parts of silk, 8~12 parts of rhodiola root, 10~15 parts of the fleece-flower root, 15~20 parts of wilsonii, 10~13 parts of mulberry fruit, Radix Rehmanniae 8~
12 parts, 10~15 parts of Radix Ophiopogonis, 10~16 parts of matrimony vine, 10~18 parts of Herba Epimedii, 15~20 parts of cassia seed, 10~15 parts of chrysanthemum, gold
12~18 parts of honeysuckle flower, 10~15 parts of cordate houttuynia, 8~12 parts of Radix Angelicae Sinensis, 5~10 parts of milk thistle, 5~10 parts of mulberry leaf, the fruit of glossy privet 10~
15 parts, 10~15 parts of 10~15 parts of Rhizoma Atractylodis Macrocephalae, STEVIA REBAUDIANA ratios weigh；
（2）Pretreatment of raw material：Pretreatment of raw material is carried out respectively according to property of raw material difference：
1. by ginseng, Semen Cuscutae, rhodiola root, the fleece-flower root, wilsonii, Radix Rehmanniae, Radix Ophiopogonis, Herba Epimedii, cassia seed, chrysanthemum, honeysuckle,
Pulverization process is carried out after cordate houttuynia, Radix Angelicae Sinensis, milk thistle, mulberry leaf, the fruit of glossy privet, Rhizoma Atractylodis Macrocephalae, STEVIA REBAUDIANA mixing, crosses 40 mesh sieve；
2. mulberry fruit, matrimony vine are mixed, 2~3 times of pure water are added, then 1~2% pectase is added, in 40~50 DEG C of items in mashing
10~20min is digested under part；
（3）Ultrasound-assisted enzymolysis：Than 3~5 times pure water of material quality are added after raw material mixing, material quality ratio is then added
2~3% cellulases, 1~2% non-starch polysaccharide enzyme digest 30~60min, hydrolysis temperature control under ultrasonic wave subsidiary conditions
At 40~50 DEG C；
（4）Centrifugation：Centrifuge leaching liquor and middle medicinal herbs residue；
（5）Distillation：The pure water of 3~5 times of amounts is added into Chinese herbal medicine residue, collects 8~10h of volatile oil, volatile oil is individually received
Collection is placed, and aqueous solution filtering merges with leaching liquor；
（6）Volatile oil emulsifies：1.5~2.0% cosolvent Tween-80, heating emulsification will be added in the volatile oil of collection；
（7）Decocting：The water of 2~3 times of amounts will be added in Chinese herbal medicine residue after distillation, decoct 3 times, every time 1.5~2h, decocting liquid
Merge with leaching liquor；
（8）It is concentrated under reduced pressure：Aqueous solution after merging is concentrated into the clear cream of 1g/ml, is let cool；
（9）Alcohol precipitation：48h or more is placed under the conditions of the ethyl alcohol of addition 95% makes alcohol content reach 60~70%, 4 DEG C into clear cream；
（10）Alcohol extracting：50% ethyl alcohol of 4~6 times of amounts, heating extraction 2 times, extraction time are added into the Chinese herbal medicine residue after decocting
1~1.5h；
（11）Merge and filters：Liquid after alcohol precipitation is merged into suction filtration with alcohol extract；
（12）It is recovered under reduced pressure：Smoke filtrate be recovered under reduced pressure ethyl alcohol to no alcohol taste；
（13）Mixing：The volatile oil emulsified is added into concentrate while hot, stirs evenly；
（14）Add auxiliary material：0.10~0.15% potassium sorbate and 1~2% sweetener is added, water is added to stir constant volume；
（15）It stands：48h or more will be stood under oral solution semi-finished product room temperature；
（16）Centrifugation：Oral solution semi-finished product 3000r/min is centrifuged into 5~10min；
（17）Constant volume dispenses：By after centrifugation oral solution constant volume, dispense up to oral solution finished product.
2. application according to claim 1, it is characterised in that the sweetener was selected is xylitol, oligomeric different malt
The mixture of one or more of sugar, honey.
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| CN110157589A (en) * | 2019-06-04 | 2019-08-23 | 阳信鼎致集团有限公司 | A kind of pear health-care vinegar and its preparation process |
| CN111012840A (en) * | 2019-12-26 | 2020-04-17 | 刘永 | Ginseng and chrysanthemum health tea for relieving eye fatigue and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1262072A (en) * | 1999-01-30 | 2000-08-09 | 李连成 | Beverage for balancing original vital energies |
| CN1843457A (en) * | 2006-02-20 | 2006-10-11 | 王信锁 | Oral liquid for promoting eyesight and protecting eye |
| CN104116900A (en) * | 2014-08-07 | 2014-10-29 | 赵西迷 | Traditional Chinese medicine dressing for preventing and treating myopia and preparation method of traditional Chinese medicine dressing |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005287376A (en) * | 2004-03-31 | 2005-10-20 | Q P Corp | Food and beverage composition for asthenopia |
-
2015
- 2015-02-03 CN CN201510054127.6A patent/CN104547534B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1262072A (en) * | 1999-01-30 | 2000-08-09 | 李连成 | Beverage for balancing original vital energies |
| CN1843457A (en) * | 2006-02-20 | 2006-10-11 | 王信锁 | Oral liquid for promoting eyesight and protecting eye |
| CN104116900A (en) * | 2014-08-07 | 2014-10-29 | 赵西迷 | Traditional Chinese medicine dressing for preventing and treating myopia and preparation method of traditional Chinese medicine dressing |
Non-Patent Citations (1)
| Title |
|---|
| 龙眼多糖超声波-酶解辅助提取工艺优化;易阳等;《农业机械学报》;20100531;第41卷(第5期);第131-136页 * |
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