Summary of the invention
The technical problem to be solved in the present invention provides a kind of cold tea of preventing and treating the inferior health constipation.
The technical scheme that the present invention solves the problems of the technologies described above is:
A kind of cold tea of preventing and treating the inferior health constipation, this cold tea is prepared by water and following materials of weight proportions: 10~30 parts of 15~40 parts of Radix Polygoni Multifloris, 15~40 parts of dandelions, 5~25 parts of the dried immature fruit of citron oranges, 5~20 parts of cassia seeds and white sugar.
In the such scheme, 10~30 parts of 20~35 parts of described raw material proportion optimization Radix Polygoni Multifloris, 20~35 parts of dandelions, 10~20 parts of the dried immature fruit of citron oranges, 10~20 parts of cassia seeds and white sugar, the best are 15 parts of 20 parts of Radix Polygoni Multifloris, 20 parts of dandelions, 15 parts of the dried immature fruit of citron oranges, 15 parts of cassia seeds and white sugar.
The preparation method of cold tea of the present invention is made up of following steps:
(1) described raw material is handled by respectively following method:
White sugar through behind the high temperature sterilization, is added 8~12 times of water, after steam low-grade fever and abundant stirring and dissolving, filter, get white sugar water;
The fleece-flower root, dandelion, the dried immature fruit of citron orange, cassia seed through after soaking 30 minutes, are put into head tank, add 8~12 times of water, boiled 2 hours, extract liquid out, in head tank, add 8~12 times of water once more, boiled 2 hours, merge decoction liquor twice, filter;
(2) preparating liquid: will join in the described decoction liquor through above-mentioned white sugar water, and fully stir, and get soup;
(3) adopt ZTC1+1 II type natural clarifying agent clarification filtration: prepare A component solution and B component solution in the described fining agent by the product description of ZTC1+1 II type natural clarifying agent, then the slow thread of the B component solution of 6% medicine liquid volume is added in the soup, stir evenly, the slow thread of A component with 8% medicine liquid volume adds in the soup again, stir evenly, put in 60~70 ℃ of water-baths and be incubated 1h, normal temperature leaves standstill 24h then, centrifugal after the coarse filtration, get supernatant, adding water to the quality of used former medicine and the volume ratio of soup is 1: 30~60.
(4) sterilization cooling: adopt steam to carry out sterilization, sterilization temperature is 120 ℃, keeps 30 minutes, and back-pressure is cooled to 30~40 ℃;
(5) filling and sealing: in vacuum is 0.03~0.04Mpa, and fluid temperature is a vacuum filling under 60~65 ℃ the condition, in time seals after canned.
Each step strictness is subjected to aseptic control in the method for the invention, and used water should meet the standard of direct drinking in the step (1).
ZTC1+1 II type natural clarifying agent used in the inventive method is a kind of food additives, form by A component and B component, wherein the A component can " bridge formation " connection increase molecule rapidly between different soluble large molecules, B component " bridge formation " again on the basis of the formed compound of A component makes floccule form precipitation as early as possible so that remove.ZTC1+1 II type natural clarifying agent answers by specification to be mixed with solution before using, and concrete compound method is as follows:
The A component solution: take by weighing 1Kg A component fine powder, add low amounts of water, stir into pasty state, add water again and be settled to 100L, leave standstill 24h, stir, double gauze filters.
The B component solution: take by weighing 1Kg B component fine powder, add a small amount of 1% glacial acetic acid, stir into pasty state, add 1% glacial acetic acid again and be settled to 100L, leave standstill 24h, stir, double gauze filters.
The present invention selects for use natural materials such as Radix Polygoni Multiflori, dandelion, the dried immature fruit of citron orange, cassia seed to dispose, the anticorrisive agent, pigment, essence and the additive that do not contain any chemical composition, can relax bowel, grow liver and kidney benefiting, abdomen, the combination of logical benefit are led in detoxifcation, can significantly improve the constipation situation of sub-health population.Wherein,
Radix Polygoni Multiflori has defaecation detoxifcation preventing malaria, enrich and benefit essence and blood, Gu the effect of kidney and blackening hair can be controlled the having a dizzy spell of the dry constipation of intestines, liver kidney essense anemia void, palpitation and insomnia, sallow weak, poliosis;
Dandelion has clearing heat and detoxicating and the effect diuresis dissipating bind, can play the merit of detoxicating intestine in cold tea of the present invention.
The dried immature fruit of citron orange has relieving stagnant Qi and removes ruffian, reduces phlegm that it is long-pending to disappear, the effect that sharp the five internal organs and beneficial gas are made light of one's life by commiting suicide;
Cassia seed has clearing liver, makes eye bright, the merit of Li Shui, defaecation, controls the wind-heat cute conjunctivitis, glaucoma, night blindness, hypertension, hepatitis, cirrhotic ascites and habitual constipation;
White sugar has the effect that moistening lung is promoted the production of body fluid;
More than all medicines share can through-supplementation, relax bowel, well alleviate the constipation symptom of sub-health population; In addition, cold tea property of medicine gentleness of the present invention, the sweet cold and not bitter of distinguishing the flavor of easily is that people accept.The used bulk drug of cold tea of the present invention is common medicinal material, moderate cost, and material is easy to get, and preparation technology is simple, is suitable for industrialization production.
In order better to understand the present invention, now study cold tea of the present invention by experiment, to inquire into its bowel relaxing functions effect to the intestinal motility of experiment mice, the influence of defecation time, fecal grains and stool weight first.
1 materials and methods
1.1 tried thing and test liquid prepares
Tried thing for embodiment 1 prepared prevent the coprostasis type sub-health cold tea, human body recommended amounts (by contained former medicine weight) is 120~240mg/Kg.BW.d.
1.2 animal used as test
120 of SPF level Male Kunming strain mice, body weight are 18~22g, are provided by Nanfang Medical Univ's medical experiment animal center.The experimental animal room quality certification number: SCXK Guangdong 2006-0015.
1.3 the experiment grouping: basic, normal, high three dosage groups are established in cold tea administration of the present invention, dosage is 1200,2400 respectively, 3600mg/kg.BW (be equivalent to respectively human body minimum recommended amount 10,20,30 times), establishes constipation model control group and negative control group simultaneously.Every group of 12 animals.
1.4 instrument and reagent operating scissors, ophthalmology tweezer, ruler, electronic balance, activated carbon powder, gum arabic (chemical reagent station, Shanghai packing factory; 19950314), (Wujin, changzhou pharmaceutical factory produces R-1132, lot number: 20010301) etc. lot number:.
1.5 experimental technique
1.5.1 intestinal motility experiment
Each experimental group by 1200,2400,3600mg/kg.BW (all transferring to equal volume) per os gives cold tea of the present invention, two control groups give isopyknic distilled water, every day 1 time, give cold tea of the present invention 7 days continuously.Last is given each treated animal fasting in evening on the same day (drinking-water is not limit) of sample, and model control group and 3 dosage groups give the compound diphenoxylate solution (0.2m1/10g.BW) that dosage is 2mg/kg.B W after 16 hours, and negative control group gives distilled water.After 30 minutes, 3 dosage groups contain the prepared Chinese ink (containing 5% activated carbon powder, 10% gum arabic) of cold tea of the present invention, and model control group and negative control group give prepared Chinese ink.Give prepared Chinese ink after 25 minutes cervical vertebra dislocation put to death animal, open the abdominal cavity and separate mesenterium, the clip upper end is the intestinal tube to ileocecus from pylorus, lower end, places on the pallet, gently small intestine is pulled into straight line and measures.Intestinal tube length is " small intestine total length ", is " prepared Chinese ink propelling length " from pylorus to prepared Chinese ink forward position.Calculate prepared Chinese ink propelling rate (P) by following formula, statistical analysis again after the line data of the going forward side by side conversion (X).
1.5.2 the mensuration of defecation time, fecal grains and stool weight
Each experimental group by 1200,2400,3600mg/kg.BW (all transferring to equal volume) per os gives cold tea of the present invention, two control groups give isopyknic distilled water, every day 1 time, successive administration 7 days.Last is given each treated animal fasting in evening on the same day (drinking-water is not limit) of sample, and model control group and 3 dosage groups give the compound diphenoxylate that dosage is 10mg/kg.BW dosage (0.2ml/10g.BW) after 16 hours, and negative control group gives the distilled water of equivalent.Give behind the compound diphenoxylate 30 minutes, model control group and negative control group mouse give prepared Chinese ink and irritate stomach, and 3 dosage groups contain the prepared Chinese ink of corresponding cold tea of the present invention, pick up counting simultaneously.Every animal is all raised separately, and supplies with feed and drinking-water, and every animal of observed and recorded is arranged defecation grain number and weight in melena time, 5 hours first.
1.5.3 experimental data is carried out the variance analysis statistical disposition with the SPSS13.0 statistical software.
2 experimental results
2.1 cold tea of the present invention is to the influence of ordinary circumstance and the body weight of animal
After giving cold tea of the present invention, the diet of each treated animal and movable normal, the ight soil of dosage group mouse is than the soft of control group and do not occur just rare.Body weight and negative control group and model control group comparing difference there are no significant meaning when experimental mice finishes in experiment (P〉0.05), show that cold tea of the present invention does not have influence to weight of mice.See Table 1.
Weight ratio before and after the experiment of each treated animal of table 1 is (x ± s)
Annotate: comparing difference there are no significant meaning between each group in the table (P〉0.05)
2.2 cold tea of the present invention is to the influence of mouse small intestine motion
The prepared Chinese ink propelling rate of constipation model control group mouse significantly is lower than negative control group (P<0.01), and expression constipation model is set up.The prepared Chinese ink propelling rate of high, medium and low dosage group mouse is higher than model control group, statistical analysis after data transaction, and the difference of high, medium and low dosage group of the present invention and constipation model control group has conspicuousness meaning (P<0.05).See Table 2.
Table 2 is respectively organized the result (x ± s) of mouse small intestine ahead running
Annotate: the P value compares for each group and constipation model control group.
2.3 cold tea of the present invention is to the influence of mouse defecation time, fecal grains and stool weight
Just and grain number and the stool weight of ight soil illustrates the establishment of constipation model all less than negative control group (P<0.01) to the little mouse's head of constipation model control group greater than negative control group (P<0.01) time.The head of each dosage group is the shortening of time ratio constipation model control group just, and high, medium and low dosage group is compared difference with it all have conspicuousness meaning (P<0.01); High, medium and low dosage group fecal grains is all greater than the constipation model control group, and with the difference of constipation model control group conspicuousness meaning (P<0.05) arranged; The stool weight of high, medium and low dosage group is greater than the constipation model control group, and with the difference of constipation model control group conspicuousness meaning (P<0.05) arranged.See Table 3.
Table 3 is respectively organized mouse defecation time, fecal grains and stool weight result (x ± s)
Annotate: the P value compares for each group and constipation model control group.
3 discuss
Experimental result shows that cold tea of the present invention can obviously promote the mouse small intestine motion, increases fecal grains, stool weight and shortens defecation time first.Show that cold tea of the present invention has the effect of defaecation.Constipation is the elderly modal gastrointestinal symptom, especially the elderly because the enterocinesia function is corresponding weakens, the abdominal muscles unable and very few easier generation constipation of intake liquid that relaxes.Its pharmacological action of cold tea of the present invention not only acts on small intestine, the main large intestine that is; And drink cold tea liquid make-up and be the comparatively generally accepted health preserving dietotherapy traditional habit of China in time, therefore have good practical values.
The specific embodiment
The used ZTC1+1 II of following examples type natural clarifying agent became clarification technique Co., Ltd in positive day available from Beijing.
Example 1
Raw material: 15 parts of 20 parts of Radix Polygoni Multifloris, 20 parts of dandelions, 15 parts of the dried immature fruit of citron oranges, 15 parts of cassia seeds and white sugar.
Preparation:
(1) described raw material is handled by respectively following method:
White sugar through behind the high temperature sterilization, is added 10 times of water, after steam low-grade fever, abundant stirring and dissolving, get white sugar water after the filtration;
The fleece-flower root, dandelion, the dried immature fruit of citron orange, cassia seed through after soaking 30 minutes, are put into head tank, add 10 times of water, boiled 2 hours, extract liquid out, in head tank, add 10 times of water once more, boiled 2 hours, merge, filter twice decoction liquor;
(2) will join in the described decoction liquor through above-mentioned white sugar water, fully stir;
(3) adopt ZTC1+1 II type natural clarifying agent clarification filtration:
The A component solution of preparation ZTC1+1 II type natural clarifying agent: take by weighing 1Kg A component fine powder, add low amounts of water, stir into pasty state, add water again and be settled to 100L, leave standstill 24h, stir, double gauze filters;
The B component solution of preparation ZTC1+1 II type natural clarifying agent: take by weighing 1Kg B component fine powder, add a small amount of 1% glacial acetic acid, stir into pasty state, add 1% glacial acetic acid again and be settled to 100L, leave standstill 24h, stir, double gauze filters;
The slow thread of the B component solution of 6% medicine liquid volume is added in the soup, stir evenly, the slow thread of A component with 8% medicine liquid volume adds in the soup again, stir evenly, put in 60~70 ℃ of water-baths and be incubated 1h, normal temperature leaves standstill 24h then, and is centrifugal after the coarse filtration, and get supernatant and add extremely former medicine of pure water: soup is 1: 60;
(4) sterilization cooling: adopt steam to carry out sterilization, sterilization temperature is 120 ℃, keeps 30 minutes, and then back-pressure is cooled to 30~40 ℃, gets final product;
(5) filling and sealing: vacuum filling, vacuum degree control are at 0.03~0.04Mpa, and fluid temperature remains on 60~65 ℃, in time seal after canned.
Example 2
Raw material: 30 parts of 40 parts of Radix Polygoni Multifloris, 40 parts of dandelions, 15 parts of the dried immature fruit of citron oranges, 15 parts of cassia seeds and white sugar
Preparation:
(1) described raw material is handled by respectively following method:
White sugar through behind the high temperature sterilization, is added 8 times of water, after steam low-grade fever, abundant stirring and dissolving, get white sugar water after the filtration;
The fleece-flower root, dandelion, the dried immature fruit of citron orange, cassia seed through after soaking 30 minutes, are put into head tank, add 8 times of water, boiled 2 hours, extract liquid out, in head tank, add 8 times of water once more, boiled 2 hours, merge, filter twice decoction liquor;
(2) will join in the described decoction liquor through above-mentioned white sugar water, fully stir;
(3) adopt ZTC1+1 II type natural clarifying agent clarification filtration:
The A component solution of preparation ZTC1+1II type natural clarifying agent: take by weighing 1Kg A component fine powder, add low amounts of water, stir into pasty state, add water again and be settled to 100L, leave standstill 24h, stir, double gauze filters;
The B component solution of preparation ZTC1+1 II type natural clarifying agent: take by weighing 1Kg B component fine powder, add a small amount of 1% glacial acetic acid, stir into pasty state, add 1% glacial acetic acid again and be settled to 100L, leave standstill 24h, stir, double gauze filters;
The slow thread of the B component solution of 6% medicine liquid volume is added in the soup, stir evenly, the slow thread of A component with 8% medicine liquid volume adds in the soup again, stir evenly, put in 60~70 ℃ of water-baths and be incubated 1h, normal temperature leaves standstill 24h then, and is centrifugal after the coarse filtration, and get supernatant and add extremely former medicine of pure water: solution is 1: 30;
(4) sterilization cooling: adopt steam to carry out sterilization, sterilization temperature is 120 ℃, keeps 30 minutes, and then back-pressure is cooled to 30~40 ℃, gets final product;
(5) filling and sealing: vacuum filling, vacuum degree control are at 0.03~0.04Mpa, and fluid temperature remains on 60~65 ℃, in time seal after canned.
Example 3
Raw material: 10 parts of 15 parts of Radix Polygoni Multifloris, 15 parts of dandelions, 25 parts of the dried immature fruit of citron oranges, 20 parts of cassia seeds and white sugar
Preparation:
(1) described raw material is handled by respectively following method:
White sugar through behind the high temperature sterilization, is added 12 times of water, after steam low-grade fever, abundant stirring and dissolving, get white sugar water after the filtration;
The fleece-flower root, dandelion, the dried immature fruit of citron orange, cassia seed through after soaking 30 minutes, are put into head tank, add 12 times of water, boiled 2 hours, extract liquid out, in head tank, add 12 times of water once more, boiled 2 hours, merge, filter twice decoction liquor;
(2) will join in the described decoction liquor through above-mentioned white sugar water, fully stir;
(3) adopt ZTC1+1 II type natural clarifying agent clarification filtration:
The A component solution of preparation ZTC1+1 II type natural clarifying agent: take by weighing 1Kg A component fine powder, add low amounts of water, stir into pasty state, add water again and be settled to 100L, leave standstill 24h, stir, double gauze filters;
The B component solution of preparation ZTC1+1 II type natural clarifying agent: take by weighing 1Kg B component fine powder, add a small amount of 1% glacial acetic acid, stir into pasty state, add 1% glacial acetic acid again and be settled to 100L, leave standstill 24h, stir, double gauze filters;
The slow thread of the B component solution of 6% medicine liquid volume is added in the soup, stir evenly, the slow thread of A component with 8% medicine liquid volume adds in the soup again, stir evenly, put in 60~70 ℃ of water-baths and be incubated 1h, normal temperature leaves standstill 24h then, and is centrifugal after the coarse filtration, and get supernatant and add extremely former medicine of pure water: soup is 1: 40;
(4) sterilization cooling: adopt steam to carry out sterilization, sterilization temperature is 120 ℃, keeps 30 minutes, and then back-pressure is cooled to 30~40 ℃, gets final product;
(5) filling and sealing: vacuum filling, vacuum degree control are at 0.03~0.04Mpa, and fluid temperature remains on 60~65 ℃, in time seal after canned.
Example 4
Raw material: 10 parts of 20 parts of Radix Polygoni Multifloris, 20 parts of dandelions, 5 parts of the dried immature fruit of citron oranges, 5 parts of cassia seeds and white sugar
Preparation:
(1) described raw material is handled by respectively following method:
White sugar through behind the high temperature sterilization, is added 10 times of water, after steam low-grade fever, abundant stirring and dissolving, get white sugar water after the filtration;
The fleece-flower root, dandelion, the dried immature fruit of citron orange, cassia seed through after soaking 30 minutes, are put into head tank, add 10 times of water, boiled 2 hours, extract liquid out, in head tank, add 10 times of water once more, boiled 2 hours, merge, filter twice decoction liquor;
(2) will join in the described decoction liquor through above-mentioned white sugar water, fully stir;
(3) adopt ZTC1+1 II type natural clarifying agent clarification filtration:
The A component solution of preparation ZTC1+1 II type natural clarifying agent: take by weighing 1Kg A component fine powder, add low amounts of water, stir into pasty state, add water again and be settled to 100L, leave standstill 24h, stir, double gauze filters;
The B component solution of preparation ZTC1+1II type natural clarifying agent: take by weighing 1Kg B component fine powder, add a small amount of 1% glacial acetic acid, stir into pasty state, add 1% glacial acetic acid again and be settled to 100L, leave standstill 24h, stir, double gauze filters;
The slow thread of the B component solution of 6% medicine liquid volume is added in the soup, stir evenly, the slow thread of A component with 8% medicine liquid volume adds in the soup again, stir evenly, put in 60~70 ℃ of water-baths and be incubated 1h, normal temperature leaves standstill 24h then, and is centrifugal after the coarse filtration, and get supernatant and add extremely former medicine of pure water: solution is 1: 50;
(4) sterilization cooling: adopt steam to carry out sterilization, sterilization temperature is 120 ℃, keeps 30 minutes, and then back-pressure is cooled to 30~40 ℃, gets final product;
(5) filling and sealing: vacuum filling, vacuum degree control are at 0.03~0.04Mpa, and feed temperature remains on 60~65 ℃, in time seal after canned.
Example 5
Raw material: 30 parts of 40 parts of Radix Polygoni Multifloris, 40 parts of dandelions, 25 parts of the dried immature fruit of citron oranges, 25 parts of cassia seeds and white sugar
Preparation:
(1) described raw material is handled by respectively following method:
White sugar through behind the high temperature sterilization, is added 8~12 times of water, after steam low-grade fever, abundant stirring and dissolving, get white sugar water after the filtration;
The fleece-flower root, dandelion, the dried immature fruit of citron orange, cassia seed through after soaking 30 minutes, are put into head tank, add 12 times of water, boiled 2 hours, extract liquid out, in head tank, add 12 times of water once more, boiled 2 hours, merge, filter twice decoction liquor;
(2) will join in the described decoction liquor through above-mentioned white sugar water, fully stir;
(3) adopt ZTC1+1 II type natural clarifying agent clarification filtration:
The A component solution of preparation ZTC1+1 II type natural clarifying agent: take by weighing 1Kg A component fine powder, add low amounts of water, stir into pasty state, add water again and be settled to 100L, leave standstill 24h, stir, double gauze filters;
The B component solution of preparation ZTC1+1 II type natural clarifying agent: take by weighing 1Kg B component fine powder, add a small amount of 1% glacial acetic acid, stir into pasty state, add 1% glacial acetic acid again and be settled to 100L, leave standstill 24h, stir, double gauze filters;
The slow thread of the B component solution of 6% medicine liquid volume is added in the soup, stir evenly, the slow thread of A component with 8% medicine liquid volume adds in the soup again, stir evenly, put in 60~70 ℃ of water-baths and be incubated 1h, normal temperature leaves standstill 24h then, and is centrifugal after the coarse filtration, and get supernatant and add extremely former medicine of pure water: solution is 1: 30;
(4) sterilization cooling: adopt steam to carry out sterilization, sterilization temperature is 120 ℃, keeps 30 minutes, and then back-pressure is cooled to 30~40 ℃, gets final product;
(5) filling and sealing: vacuum filling, vacuum degree control are at 0.03~0.04Mpa, and feed temperature remains on 60~65 ℃, in time seal after canned.