CN104547534A - Chinese herbal medicine health oral liquid with efficacy of relieving visual fatigue - Google Patents
Chinese herbal medicine health oral liquid with efficacy of relieving visual fatigue Download PDFInfo
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Abstract
The invention discloses a Chinese herbal medicine health oral liquid with an efficacy of relieving visual fatigue. 1,000 parts of health oral liquid comprise the following Chinese herbal medicine materials in parts by weight: 5-10 parts of ginseng, 10-15 parts of semen cuscutae, 8-12 parts of rhodiola rosea, 10-15 parts of polygonum multiflorum, 15-20 parts of manyprickle acanthopanax root, 10-13 parts of mulberry, 8-12 parts of dried radix rehmanniae, 10-15 parts of radix ophiopogonis, 10-16 parts of wolfberry, 10-18 parts of herba epimedii, 15-20 parts of semen cassia, 10-15 parts of chrysanthemum, 12-18 parts of honeysuckle, 10-15 parts of houttuynia cordata, 8-12 parts of angelica sinensis, 5-10 parts of silybum marianum, 5-10 parts of mulberry leaves, 10-15 parts of glossy privet fruit, 10-15 parts of rhizoma atractylodis macrocephalae and 10-15 parts of stevia rebaudiana. The Chinese herbal medicine health oral liquid is prepared by an ultrasonic wave-assisted extraction technology, a volatile oil distillation technology, a decoction technology and an alcohol extraction technology. The Chinese herbal medicine health oral liquid has the advantages of being good in visual fatigue relieving efficacy, safe, free of side effects, convenient to drink and the like.
Description
Technical field
The present invention relates to a kind of herbal health care oral liquid with efficacy of relieving visual fatigue, particularly a kind of take vegetable Chinese herbal medicine as the health care oral liquid that raw material is made, and belongs to herbal health care field.
Background technology
Asthenopia also known as eyestrain, the former noun in order to describe the series of symptoms relevant to excess eye-using.Because its producing cause complexity is various, most scholar thinks that asthenopic generation is the result that eye or whole body apparatus factors and psychologic factors are intertwined to form, belong to somatopsychic medicine's category, but usually with the conscious eye symptom of patient for outstanding behaviours, therefore, eyestrain's syndrome is often called again clinically.According to clinical investigation, dioptric does not obtain correct rectification and accommodative excess and light-source brightness is insufficient, ambient brightness is uneven etc. is the asthenopic main cause of generation.When can produce under asthenopia serious conditions headache, dizzy, bring out the symptoms such as stomach dysfunction, spasm of ocular muscles, whole body be uncomfortable, a large amount of universal especially along with video terminals such as computers, make asthenopic incidence rate in the trend risen gradually.Therefore, asthenopic Crack cause, pathogenesis and control more and more obtain the concern of people.
Chinese herbal medicine is the rarity of Chinese traditional culture, along with the progressively raising of people's lives, the health care consciousness of people strengthens gradually, and the demand in alleviating asthenopia, pre-myopia prevention etc. increases day by day, Chinese herbal medicine in this field health food development process in occupation of innate advantage condition.For passing on Chinese herbal medicine culture of long standing and well established, meet the demand of the people to health care, the present invention chooses the Chinese herbal medicine with effects such as QI invigorating tonification, strengthening the body resistance, develops the herbal health care oral liquid with efficacy of relieving visual fatigue.
Summary of the invention
For overcoming the deficiency of existing product for relieving visual fatigue technology, the object of the present invention is to provide a kind of herbal health care oral liquid evil with alleviating asthenopia, prevention vision harm health-care effect.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
The invention provides a kind of herbal health care oral liquid with efficacy of relieving visual fatigue, it is characterized in that: in 1000 portions of oral liquids, raw material of Chinese medicine and quality proportioning are: Radix Ginseng 5 ~ 10 parts, Semen Cuscutae 10 ~ 15 parts, Radix Rhodiolae 8 ~ 12 parts, Radix Polygoni Multiflori 10 ~ 15 parts, Radix Et Caulis Acanthopanacis Senticosi 15 ~ 20 parts, 10 ~ 13 parts, Fructus Mori, 8 ~ 12 parts, the Radix Rehmanniae, Radix Ophiopogonis 10 ~ 15 parts, Fructus Lycii 10 ~ 16 parts, Herba Epimedii 10 ~ 18 parts, Semen Cassiae 15 ~ 20 parts, Flos Chrysanthemi 10 ~ 15 parts, Flos Lonicerae 12 ~ 18 parts, Herba Houttuyniae 10 ~ 15 parts, Radix Angelicae Sinensis 8 ~ 12 parts, Herba Silybi mariani 5 ~ 10 parts, 5 ~ 10 parts, Folium Mori, Fructus Ligustri Lucidi 10 ~ 15 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 parts, Folium Stevlae Rebaudianae 10 ~ 15 parts.
The preferred technical solution of the present invention is: a kind of herbal health care oral liquid with efficacy of relieving visual fatigue, is characterized in that: its raw material of Chinese medicine and quality proportioning are: Radix Ginseng 8 parts, Semen Cuscutae 13 parts, Radix Rhodiolae 12 parts, Radix Polygoni Multiflori 12 parts, Radix Et Caulis Acanthopanacis Senticosi 16 parts, 12 parts, Fructus Mori, 10 parts, the Radix Rehmanniae, Radix Ophiopogonis 14 parts, Fructus Lycii 15 parts, Herba Epimedii 15 parts, Semen Cassiae 18 parts, Flos Chrysanthemi 12 parts, Flos Lonicerae 15 parts, Herba Houttuyniae 12 parts, Radix Angelicae Sinensis 10 parts, Herba Silybi mariani 7 parts, 8 parts, Folium Mori, Fructus Ligustri Lucidi 13 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Folium Stevlae Rebaudianae 13 parts.
The invention provides a kind of herbal health care oral liquid with efficacy of relieving visual fatigue, it is characterized in that being prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, removes impurity etc., weighs according to aforementioned proportion;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after Radix Ginseng, Semen Cuscutae, Radix Rhodiolae, Radix Polygoni Multiflori, Radix Et Caulis Acanthopanacis Senticosi, the Radix Rehmanniae, Radix Ophiopogonis, Herba Epimedii, Semen Cassiae, Flos Chrysanthemi, Flos Lonicerae, Herba Houttuyniae, Radix Angelicae Sinensis, Herba Silybi mariani, Folium Mori, Fructus Ligustri Lucidi, the Rhizoma Atractylodis Macrocephalae, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. by Fructus Mori, Fructus Lycii mixing, add 2 ~ 3 times of pure water, making beating, then adds 1 ~ 2% pectase, enzymolysis 10 ~ 20min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 3 ~ 5 times of pure water after raw material mixing, then raw materials quality is added than 2 ~ 3% cellulase, 1 ~ 2% non-starch polysaccharide enzyme, enzymolysis 30 ~ 60min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 3 ~ 5 times amount in Chinese herbal medicine residue, collect volatile oil 8 ~ 10h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.5 ~ 2.0% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2 ~ 3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5 ~ 2h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 4 ~ 6 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1 ~ 1.5h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.10 ~ 0.15% and the sweeting agent of 1 ~ 2%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 5 ~ 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
The mixture of one or more that what above-mentioned sweeting agent was selected is in xylitol, oligomeric isomaltose, Mel.
Chinese medicine combination of the present invention is selected prescription under Traditional Chinese medical theory and practical advice.In Chinese medicine composition of the present invention: effect that Radix Ginseng has " tonifying five ZANG-organs, peace spirit, determine soul, spasmolytic is throbbed with fear, except pathogen, happy Fructus Alpiniae Oxyphyllae tomorrow ", " take for a long time make light of one's life by commiting suicide prolong life ", in Chinese herbal medicine, Radix Ginseng is all listed in top grade for thousands of years; Semen Cuscutae abnormal smells from the patient is pungent, sweet, flat nontoxic, cure mainly the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, the waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion; Radix Rhodiolae energy improving water flood, blood-enriching and blood-promoting circulation, anti-cerebral anoxia, resisting fatigue, promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, change become silted up detumescence, antipyreticly to bring down a fever, nourish the effects such as vigour; Radix Polygoni Multiflori has promotion hemopoietic function, and improve body's immunity, blood fat reducing, atherosclerosis, protects the liver, and slow down aging affects endocrine function, the effects such as loosening bowel to relieve constipation; Radix Et Caulis Acanthopanacis Senticosi has the disorder of adjustment body to be made it to be tending towards normal function, and have good antifatigue effect, comparatively Radix Ginseng is remarkable, the function such as invigorating middle warmer, benefit essence, strong will, wind-damp dispelling, strengthening bone and muscle, blood circulation and promoting silt, stomach invigorating diuresis, clothes " make light of one's life by commiting suicide and endure hardships " of a specified duration; Fructus Mori contains abundant activated protein, provitamin A, B
1, B
2, PP and C, aminoacid, malic acid, succinic acid, tartaric acid, carotene, mineral calcium, phosphorus, ferrum, copper, the composition such as zinc, there is raising body immunity there is the multiple efficacies such as slow down aging looks improving and the skin nourishing, be described as " the best health fruit of 21st century " by medical circle; The effects such as the Radix Rehmanniae has heat clearing away, promotes the production of body fluid, moisturizes, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, the incised wound stasis of blood, removing heat from blood, hemostasis; Sweet, the micro-hardship of property Radix Ophiopogonis, cool, Yin-nourishing and body fluid promoting, nourishing the lung to arrest cough, clear away heart-fire relieving restlessness.Cure mainly consumption of body fluid caused by febrile disease, vexed, thirsty, dry pharynx lung-heat, cough, pulmonary tuberculosis; Fructus Lycii is famous and precious medical material and tonic, and the saying Compendium of Material Medica that the traditional Chinese medical science has very early " medlar health preserving " is recorded: " Fructus Lycii, kidney-tonifying sperm-generating, nourishing the liver ... improving eyesight is calmed the nerves, make us long-lived, has the effects such as nourishing the liver, nourishing kidney, lung moistening; Herba Epimedii has the effects such as kidney-replenishing, bone and muscle strengthening, wind-damp dispelling; Semen Cassiae has the function of liver heat removing and eyesight improving, relieving constipation, cures mainly hypertension, headache, dizzy, the disease such as acute conjunctivitis, corneal ulcer, glaucoma, carbuncle furuncle infections; Flos Chrysanthemi is sweet, be slightly cold, and has loose wind heat, suppressing the hyperactive liver improving eyesight, disappears and cough effect of pain relieving, be used for the treatment of the disease Be very effective such as headache is dizzy, conjunctival congestion and swelling pain, anemopyretic cold, cough, also have effect of refreshment; Flos Lonicerae Flos Lonicerae contains the necessary trace element of multiple human body and chemical composition, simultaneously containing the multiple organized enzyme material favourable to human body, has defying age, anti-canceration, the good effects of being healthy and strong of making light of one's life by commiting suicide; Herba Houttuyniae has the effect of function of relieving visual fatigue and enhancing human body immunity function, and without any side effects, is applicable to, often close to the personnel of radiation source, as X-ray machine and computer operater, and often see the crowd of TV; The radioprotective food that computer gang must eat; Radix Angelicae Sinensis has to enrich blood invigorates blood circulation, menstruction regulating and pain relieving, the effects such as loosening bowel to relieve constipation, for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores; Herba Silybi mariani has heat-clearing and toxic substances removing, protects the liver, function of gallbladder promoting, protects brain, the effects such as anti-X-ray; Folium Mori have the effects such as blood pressure lowering, blood fat, antiinflammatory, and major function is dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving, for anemopyretic cold, and lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted; Fructus Ligustri Lucidi sweet, bitter, cold, function cures mainly nourishing the liver and kidney, improving eyesight black hair, for vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision; The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, the effect such as antiabortive, has loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement for insufficiency of the spleen lack of appetite, abdominal distention.
The selected Chinese herbal medicine formula of the present invention, its drug component, through dialectical compatibility, helps using mutually assistant, can prevent the asthenopia because excess eye-using causes; Can prevent because too high electromagnetic radiation impacts visual system, can the visual deterioration, xerophthalmia, cataract etc. that cause of anti-electromagnetic radiation in advance.
The invention provides a kind of herbal health care oral liquid with efficacy of relieving visual fatigue, it is advantageous that: one is the multiple Chinese herbal medicine of scientific compatibility, can effective alleviating asthenopia; Two is the technique adopting " Ultrasonic Wave-Assisted Extraction+volatile matter distillation oil+decocting+alcohol extraction " in the preparation process of oral liquid, fully mixes the functional active components of the alleviating asthenopia in Chinese herbal medicine, improves therapeutic effect; Three is that oral liquid has no side effect safely, drinks conveniently.
The invention provides a kind of herbal health care oral liquid of alleviating asthenopia, carried out toxicology test and the safety evaluatio of health care oral liquid by animal experiment.Chmice acute Oral toxicity result of the test shows, this health care oral liquid is greater than high dose group 75mg/kgbw to chmice acute per os maximum tolerated dose; Genetic toxicity test mouse marrow cell micro nuclear test and mouse inbred strain two result of the tests are feminine gender, show that this health care oral liquid is without mutagenic action; From rat 30d feeding trial, the behavior of rat sign is normal, figure is healthy, blood and blood parameters also change without exception, and therefore the dosage (150 times of human body recommended amounts) of 75mg/kgbw belongs to safe dose; Genetic toxicity test and rat 30d feeding trial result are feminine gender, therefore determine that this health beverage belongs to non-toxic type food, and people can be safe relieved edible.
Detailed description of the invention
below in conjunction with embodiment, the present invention will be further described.
embodiment 1:
There is a herbal health care oral liquid for efficacy of relieving visual fatigue, prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to Radix Ginseng 8 parts, Semen Cuscutae 13 parts, Radix Rhodiolae 12 parts, Radix Polygoni Multiflori 12 parts, Radix Et Caulis Acanthopanacis Senticosi 16 parts, 12 parts, Fructus Mori, 10 parts, the Radix Rehmanniae, Radix Ophiopogonis 14 parts, Fructus Lycii 15 parts, Herba Epimedii 15 parts, Semen Cassiae 18 parts, Flos Chrysanthemi 12 parts, Flos Lonicerae 15 parts, Herba Houttuyniae 12 parts, Radix Angelicae Sinensis 10 parts, Herba Silybi mariani 7 parts, 8 parts, Folium Mori, Fructus Ligustri Lucidi 13 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Folium Stevlae Rebaudianae 13 parts of ratios in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after Radix Ginseng, Semen Cuscutae, Radix Rhodiolae, Radix Polygoni Multiflori, Radix Et Caulis Acanthopanacis Senticosi, the Radix Rehmanniae, Radix Ophiopogonis, Herba Epimedii, Semen Cassiae, Flos Chrysanthemi, Flos Lonicerae, Herba Houttuyniae, Radix Angelicae Sinensis, Herba Silybi mariani, Folium Mori, Fructus Ligustri Lucidi, the Rhizoma Atractylodis Macrocephalae, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. by Fructus Mori, Fructus Lycii mixing, add 2.5 times of pure water, making beating, then adds 1.5% pectase, enzymolysis 15min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 4 times of pure water after raw material mixing, then add raw materials quality than 2.5% cellulase, 1.5% non-starch polysaccharide enzyme, enzymolysis 45min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 4 times amount in Chinese herbal medicine residue, collect volatile oil 9h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.8% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2.5 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.8h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 5 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1.2h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.12% and the xylitol of 1.5%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 8min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
embodiment 2:
There is a herbal health care oral liquid for efficacy of relieving visual fatigue, prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to Radix Ginseng 10 parts, Semen Cuscutae 10 parts, Radix Rhodiolae 12 parts, Radix Polygoni Multiflori 10 parts, Radix Et Caulis Acanthopanacis Senticosi 20 parts, 10 parts, Fructus Mori, 12 parts, the Radix Rehmanniae, Radix Ophiopogonis 10 parts, Fructus Lycii 16 parts, Herba Epimedii 10 parts, Semen Cassiae 20 parts, Flos Chrysanthemi 10 parts, Flos Lonicerae 18 parts, Herba Houttuyniae 10 parts, Radix Angelicae Sinensis 12 parts, Herba Silybi mariani 5 parts, 10 parts, Folium Mori, Fructus Ligustri Lucidi 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Folium Stevlae Rebaudianae 10 parts of ratios in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after Radix Ginseng, Semen Cuscutae, Radix Rhodiolae, Radix Polygoni Multiflori, Radix Et Caulis Acanthopanacis Senticosi, the Radix Rehmanniae, Radix Ophiopogonis, Herba Epimedii, Semen Cassiae, Flos Chrysanthemi, Flos Lonicerae, Herba Houttuyniae, Radix Angelicae Sinensis, Herba Silybi mariani, Folium Mori, Fructus Ligustri Lucidi, the Rhizoma Atractylodis Macrocephalae, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. by Fructus Mori, Fructus Lycii mixing, add 3 times of pure water, making beating, then adds 2% pectase, enzymolysis 10min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 5 times of pure water after raw material mixing, then add raw materials quality than 3% cellulase, 2% non-starch polysaccharide enzyme, enzymolysis 30min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 5 times amount in Chinese herbal medicine residue, collect volatile oil 8h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 2.0% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 6 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.15% and the oligomeric isomaltose of 2%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
embodiment 3:
There is a herbal health care oral liquid for efficacy of relieving visual fatigue, prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to Radix Ginseng 5 parts, Semen Cuscutae 15 parts, Radix Rhodiolae 8 parts, Radix Polygoni Multiflori 15 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, 13 parts, Fructus Mori, 8 parts, the Radix Rehmanniae, Radix Ophiopogonis 15 parts, Fructus Lycii 10 parts, Herba Epimedii 18 parts, Semen Cassiae 15 parts, Flos Chrysanthemi 15 parts, Flos Lonicerae 12 parts, Herba Houttuyniae 15 parts, Radix Angelicae Sinensis 8 parts, Herba Silybi mariani 10 parts, 5 parts, Folium Mori, Fructus Ligustri Lucidi 15 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Folium Stevlae Rebaudianae 15 parts of ratios in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after Radix Ginseng, Semen Cuscutae, Radix Rhodiolae, Radix Polygoni Multiflori, Radix Et Caulis Acanthopanacis Senticosi, the Radix Rehmanniae, Radix Ophiopogonis, Herba Epimedii, Semen Cassiae, Flos Chrysanthemi, Flos Lonicerae, Herba Houttuyniae, Radix Angelicae Sinensis, Herba Silybi mariani, Folium Mori, Fructus Ligustri Lucidi, the Rhizoma Atractylodis Macrocephalae, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. by Fructus Mori, Fructus Lycii mixing, add 2 times of pure water, making beating, then adds 1% pectase, enzymolysis 20min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 3 times of pure water after raw material mixing, then add raw materials quality than 2% cellulase, 1% non-starch polysaccharide enzyme, enzymolysis 60min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 3 times amount in Chinese herbal medicine residue, collect volatile oil 10h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.5% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 2h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 4 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1.5h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.10% and the Mel of 1%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 5 ~ 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
The invention provides a kind of herbal health care oral liquid of alleviating asthenopia, different Chinese herbal medicine nature and flavor are different, effect also exists huge difference, complicated interaction relationship is there is after different Chinese herbal medicine combinations, and proportioning between Chinese herbal medicine is closer, different ratio also will make monarch relation that substantial change occurs, thus make the relation generation material alterations of composite Chinese herbal.The application passes through Radix Ginseng, Semen Cuscutae, Radix Rhodiolae, Radix Polygoni Multiflori, Radix Et Caulis Acanthopanacis Senticosi, Fructus Mori, the Radix Rehmanniae, Radix Ophiopogonis, Fructus Lycii, Herba Epimedii, Semen Cassiae, Flos Chrysanthemi, Flos Lonicerae, Herba Houttuyniae, Radix Angelicae Sinensis, Herba Silybi mariani, Folium Mori, Fructus Ligustri Lucidi, the Rhizoma Atractylodis Macrocephalae, there is complicated interaction relationship to each other in the Chinese herbal medicine such as Folium Stevlae Rebaudianae, rational proportion, achieve unforeseeable technique effect, make the relation generation material alterations of alleviating asthenopia herbal health care oral liquid, the total antioxidant capacity of the application's herbal health care oral liquid reaches 485.36 ± 23.47U/mL, change Chinese herbal medicine proportioning or Chinese herbal medicine composition can reduce the oxidation resistance of health care oral liquid.According to " function of health food assessment process and the method for inspection ", Evaluation of Functional is carried out to the application's product, result shows that test group mice skeleton cell micronucleus rate significantly reduces, peripheral cells number and Quantity of DNA obviously increase, significant difference compared with matched group, demonstrates product of the present invention and has certain protective effect to radiation hazradial bundle; Evaluate by the efficacy of relieving visual fatigue of the method contrasted between self and group to product, at random 50 asthenopes are divided into test group and matched group, after taking 30h continuously, the sense of test group asthenopia obviously alleviates, duration of photopic vision on average improves more than 24.17%, total effective rate more than 94%, before and after experiment, blood, urine, feces routine examination and blood biochemistry test rating are all normal, demonstrate effect that product of the present invention has good alleviating asthenopia.
Above embodiment only for illustration of technical scheme of the present invention, but not is limited; Although be described in detail by invention with reference to previous embodiment, for the person of ordinary skill of the art, still the technical scheme described in previous embodiment can be modified, or equivalent replacement has been carried out to wherein portion of techniques feature; And to these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of the present invention's technical scheme required for protection.
Claims (2)
1. there is a herbal health care oral liquid for efficacy of relieving visual fatigue, it is characterized in that preparation technology comprises the following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., according to Radix Ginseng 5 ~ 10 parts in every 1000 portions of oral liquids, Semen Cuscutae 10 ~ 15 parts, Radix Rhodiolae 8 ~ 12 parts, Radix Polygoni Multiflori 10 ~ 15 parts, Radix Et Caulis Acanthopanacis Senticosi 15 ~ 20 parts, 10 ~ 13 parts, Fructus Mori, 8 ~ 12 parts, the Radix Rehmanniae, Radix Ophiopogonis 10 ~ 15 parts, Fructus Lycii 10 ~ 16 parts, Herba Epimedii 10 ~ 18 parts, Semen Cassiae 15 ~ 20 parts, Flos Chrysanthemi 10 ~ 15 parts, Flos Lonicerae 12 ~ 18 parts, Herba Houttuyniae 10 ~ 15 parts, Radix Angelicae Sinensis 8 ~ 12 parts, Herba Silybi mariani 5 ~ 10 parts, 5 ~ 10 parts, Folium Mori, Fructus Ligustri Lucidi 10 ~ 15 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 parts, Folium Stevlae Rebaudianae 10 ~ 15 parts of ratios are weighed,
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after Radix Ginseng, Semen Cuscutae, Radix Rhodiolae, Radix Polygoni Multiflori, Radix Et Caulis Acanthopanacis Senticosi, the Radix Rehmanniae, Radix Ophiopogonis, Herba Epimedii, Semen Cassiae, Flos Chrysanthemi, Flos Lonicerae, Herba Houttuyniae, Radix Angelicae Sinensis, Herba Silybi mariani, Folium Mori, Fructus Ligustri Lucidi, the Rhizoma Atractylodis Macrocephalae, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. by Fructus Mori, Fructus Lycii mixing, add 2 ~ 3 times of pure water, making beating, then adds 1 ~ 2% pectase, enzymolysis 10 ~ 20min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 3 ~ 5 times of pure water after raw material mixing, then raw materials quality is added than 2 ~ 3% cellulase, 1 ~ 2% non-starch polysaccharide enzyme, enzymolysis 30 ~ 60min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 3 ~ 5 times amount in Chinese herbal medicine residue, collect volatile oil 8 ~ 10h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.5 ~ 2.0% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2 ~ 3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5 ~ 2h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 4 ~ 6 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1 ~ 1.5h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.10 ~ 0.15% and the sweeting agent of 1 ~ 2%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 5 ~ 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
2. a kind of herbal health care oral liquid with efficacy of relieving visual fatigue according to claim 1, what it is characterized in that described sweeting agent selects is the mixture of one or more in xylitol, oligomeric isomaltose, Mel.
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