CN105998639A - Oral liquid with lipid-decreasing and pressure-decreasing effects and preparation method thereof - Google Patents

Oral liquid with lipid-decreasing and pressure-decreasing effects and preparation method thereof Download PDF

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Publication number
CN105998639A
CN105998639A CN201610340261.7A CN201610340261A CN105998639A CN 105998639 A CN105998639 A CN 105998639A CN 201610340261 A CN201610340261 A CN 201610340261A CN 105998639 A CN105998639 A CN 105998639A
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parts
weight portion
fructus
corii asini
colla corii
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孙龙喜
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/066—Clavicipitaceae
    • A61K36/068—Cordyceps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/254—Acanthopanax or Eleutherococcus
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967—Lilium, e.g. tiger lily or Easter lily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention relates to an oral liquid with lipid-decreasing and pressure-decreasing effects and a preparation method thereof. The oral liquid is prepared from the following raw materials in parts by weight: 10 to 15 parts of kudzuvine root, 5 to 10 parts of rhizoma polygonati, 4 to 8 parts of fruit of Chinese wolfberry, 1 to 2 parts of rhizoma polygonati odorati, 2 to 6 parts of fingered citron, 1 to 5 parts of oxytropis psammocharis hance, 8 to 12 parts of radix angelicae dahurioae, 5 to 10 parts of arillus longan, 5 to 10 parts of dark plum, 2 to 6 parts of raspberry fruit, 2 to 6 parts of lily bulb, 4 to 8 parts of peach kernel, 5 to 10 parts of acanthopanax sessiliflorus, 1 to 5 parts of cordyceps militaris, 5 to 10 parts of donkey-hide gelatin, 1 to 5 parts of earthworm protein, 3 to 8 parts of nicotinic acid, and 15 to 20 parts of honey. The oral liquid has the advantage that the double effects of decreasing lipid and pressure can be realized.

Description

A kind of blood fat-reducing blood pressure-decreasing drink and preparation method thereof
Technical field
The present invention relates to Chinese medicine health care product field, be specifically related to a kind of drink reducing blood fat, blood pressure and preparation method thereof.
Background technology
Along with the improvement of the raising and dietary habit surviving level, in recent years, suffer from hypertension, hyperlipemia patient by Year increases.Suffer from hypertension, the patient of hyperlipidemia needs to take medicine all the life, otherwise can cause other complication, shortens the life-span.
Existing treatment hypertension, hyperlipidemia drug main will be based on Western medicine, but its side effect is relatively big, and long-term taking is serious Affect Liver and kidney function.And owing to the rising of blood fat is closely related with hypertension incidence, hypertension, hyperlipidemia are deposited the most simultaneously , existing Western medicine not occurring, a kind of hypertension of can treating can reduce again the medicine of blood fat, for i.e. suffering from hypertension again Suffer from the patient of hyperlipidemia, hypertension, two kinds of medicines of hyperlipidemia can only be taken simultaneously, so considerably increase medicine to body Infringement.Chinese medicine is constantly paid attention to by everybody with its few side effects, some treatment hypertension, hyperlipidemia has occurred Chinese medicine composition or to treat hypertension, the health product of hyperlipidemia Chinese medicine, solves the problem that Western medicine toxic and side effects is big, but It is that these product action effects are general, still can not simultaneously work as blood pressure lowering, blood fat reducing dual activity, and for serious high blood Pressure, hyperlipemic patients can not play good therapeutic effect, are only applicable to Mild or moderate hypertension patient and use.
Summary of the invention
It is an object of the invention to provide one and can either reduce blood fat, can reduce blood pressure again, have in dual activity Medicine drink, this drink remains able to play good therapeutic effect for serious hypertension, hyperlipemic patients.
For achieving the above object, technical scheme of the present invention is achieved in that this Chinese medicine drink is by following weight parts Raw material make: Radix Puerariae 10-15 part, Rhizoma Polygonati 5-10 part, Fructus Lycii 4-8 part, Rhizoma Polygonati Odorati 1-2 part, Fructus Citri Sarcodactylis 2-6 part, Herba Oxytropis Psammocharitis 1-5 Part, Radix Angelicae Dahuricae 8-12 part, Arillus Longan 5-10 part, Fructus Mume 5-10 part, Fructus Rubi 2-6 part, Bulbus Lilii 2-6 part, Semen Persicae 4-8 part, short stalk five Add 5-10 part, Cordyceps militaris (L.) Link.sporophore 1-5 part, Colla Corii Asini 5-10 part, earthworm protein 1-5 part, nicotinic acid 3-8 part, Mel 15-20 part.
As present invention further optimization, described Chinese medicine drink is made up of the raw material of following weight parts: Radix Puerariae 13 parts, Huang Essence 10 parts, Fructus Lycii 6 parts, Rhizoma Polygonati Odorati 1 part, Fructus Citri Sarcodactylis 6 parts, Herba Oxytropis Psammocharitis 5 parts, the Radix Angelicae Dahuricae 10 parts, Arillus Longan 7 parts, Fructus Mume 5 parts, Fructus Rubi 4 Part；Bulbus Lilii 3 parts, 5 parts of Semen Persicae, Cortex Acanthopancis 7 parts, Cordyceps militaris (L.) Link.sporophore 3 parts, 6 parts of Colla Corii Asini, earthworm protein 3 parts, 6 parts of nicotinic acid, honeybee Honey 19 parts.
It is a further object of the present invention to provide the preparation method of a kind of blood fat-reducing blood pressure-decreasing drink, the method comprises the following steps:
(1) Radix Puerariae of described weight portion, Rhizoma Polygonati, Fructus Lycii, Rhizoma Polygonati Odorati, Fructus Citri Sarcodactylis, Herba Oxytropis Psammocharitis, the Radix Angelicae Dahuricae, Arillus Longan, crow are weighed Prunus mume (sieb.) sieb.et zucc., Fructus Rubi, Bulbus Lilii, Semen Persicae, Cortex Acanthopancis, Cordyceps militaris (L.) Link.sporophore, pulverize, uniformly mix, put in multi-function extractor, soaks After 3-5 hour, heating decocts three times, and each amount of water is medical material amount 6-10 times, and each decocting time is 1-2 hour；Cross by several times 120 eye mesh screens, leaching medicinal liquid, it is mixed；Medicinal liquid is put in settling tank, staticly settle more than 12 hours；Take supernatant medicine in settling tank Liquid, standby；
(2) weigh the Colla Corii Asini of described weight portion, pulverize；Take the purification water of Colla Corii Asini amount 1 times again, be heated to 40-60 DEG C, add The Colla Corii Asini pulverized, stirring while adding, stir to obtain Colla Corii Asini liquid；
(3) weigh the earthworm protein of described weight portion, nicotinic acid, grind in being placed in mortar, obtained the fine powder of 200 mesh, standby With；
(4) step (1), step (2), the medicinal liquid of step (3), Colla Corii Asini liquid and fine powder are mixed, add described heavy The Mel of amount part, stirring, mix homogeneously, fill, sterilizing.
Effect of heretofore described each raw material is selected as follows:
Radix Puerariae: sweet in the mouth, pungent, property is put down, is entered lung, stomach warp.[effect] yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is quenched the thirst.Radix Puerariae contains There is the abundant important biomolecule active substance useful to human body.Wherein, the isoflavonoid puerarin in Radix Puerariae can be expanded Blood vessel, reduce blood pressure, improve microcirculation, strengthen myocardial contraction, protecting myocardial cell, to hypertension, hyperlipidemia, hyperglycemia and Cardiovascular and cerebrovascular disease has certain curative effect.
Rhizoma Polygonati Odorati: sweet in the mouth, property is put down, is entered lung, stomach warp.[effect] yin nourishing, moisturizes, relieving restlessness, quenches the thirst.[application] deficiency of lung-YIN causes Scorching, cough and phthisical cough chronic cough, have effect that nourishing YIN and clearing away lung-heat is moistened dryness and relieve cough.Can nourishing the stomach to promote the production of body fluid control interior-heat and quench one's thirst.Modern medicine Research: Rhizoma Polygonati Odorati is soft and moist product, control lung dryness of the stomach heat, body fluid dry up, thirsty dry sensation in the pharynx, excessiveness of stomach-fire, dry thirsty rapid digestion of food, polyorexia Person, still have and very imitate.There are blood pressure lowering, hypoglycemic effect.
Earthworm protein: be a kind of macromole compound enzyme extracted in Chinese traditional medicine sleeper, containing multiple free amino acid, containing many Plant active component, such as Multiple components such as collagenase, fibrinolysin, Lumbrukinase, nucleic acid, trace element, blood capillary can be entered smoothly, By recovering, blood is elastic, expand blood vessel, thrombus, improve microcirculation, thus improves circumference of cannon bone state, reduces the resistance of blood flow periphery Power, reduces blood viscosity, reduces blood pressure.Can prophylaxis of hypertension, myocardial infarction, arrhythmia, apoplexy thromboembolism etc. well.
Nicotinic acid: be the constituent of two kinds of important coenzyme of NAD and NADP, participates in human body carbohydrate, fat and albumen The metabolism of matter, has the function safeguarding application system, skin and digestive system.To expansion peripheral vessel, promote that peripheral vessel is raw Long side and reduction blood lipid level aspect have special effect.Can be used for treating hyperlipemia.It is also used for treating vascular inclined Headache, headache, cerebral artery thrombosis formation, pulmonary infarction, auditory vertigo, cold injury, central retinochoroiditis etc..
Cordyceps militaris (L.) Link.sporophore: nature and flavor are sweet flat, do not warm the most cold and cool, enters lung kidney two warp, and both tonifying the lung was cloudy, and kidney-replenishing again, is only One can the Chinese crude drug of " tonifying both YIN and YANG, balance YIN and YANG balance regulating ", have raising body immunity, antitumor, antioxidation, antiviral, Antiinflammatory, endocrine regulation, calm sleeping, resisting fatigue, defying age, spasmolytic, attenuation, blood sugar lowering, blood fat reducing, tonifying deficiency, the kidney invigorating, profit Lung, protect the liver, protect the heart, reduce phlegm, the effect of relievining asthma etc..
Colla Corii Asini: sweet in the mouth, property are flat, return liver, lung, kidney channel.[effect] tonifying blood and arresting bleeding, nourshing Yin and drynsessmoistening prescription.Excellent tonic product, tonic is used Two preferably, have nourishing YIN and supplementing blood, moisturize the function of hemostasis, and effect of enriching blood is notable.It is good at treating the various diseases that blood deficiency causes, and energy The effect of skin care is played by enriching blood.Can regulating menstruation is antiabortive, health invigorating, slow down aging, raising immunity, improve sleep, Nourishing the brain and improving intelligence, resisting fatigue, radioprotective, improve bone density and promote calcium absorption.
Fructus Lycii: sweet in the mouth, property is put down, is entered liver, kidney channel.[effect] nourishing kidney, lung moistening, tonifying liver, improving eyesight.[application] is used for Liver and kidney not Foot, essence and blood can not on help in mesh, the disease such as eyes is dim-sighted, visual deterioration.
Fructus Citri Sarcodactylis: depressed liver-energy dispersing and QI regulating, and stomach and alleviating pain, drying dampness to eliminate phlegm.
Rhizoma Polygonati: sweet in the mouth, property is put down, is entered spleen, lung, kidney channel.[effect] invigorating the spleen and replenishing QI, moistens cardiopulmonary, strong muscle.
Herba Oxytropis Psammocharitis: lightly seasoned, property is put down.[effect] digestion-promoting spleen-invigorating.
The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature, enter spleen, spleen, stomach warp.[effect] dispels the wind, dampness, detumescence, pain relieving.
Arillus Longan: sweet in the mouth, warm in nature, enter the heart, spleen channel.[effect] heart-spleen boosting, fills blood, calms the nerves.
Fructus Mume: sour in the mouth, warm in nature, enter liver, spleen, lung, large intestine channel.[effect] convergence is promoted the production of body fluid, relieving colic caused by ascaris anthelmintic.
Fructus Rubi: supplementing the kidney to control the nocturnal reducing urination, nourishing the liver to improve visual acuity.
Bulbus Lilii: sweet and slightly bitter taste, property is put down, is entered the heart, lung meridian.[effect] nourishing the lung to arrest cough, clearing away heart-fire for tranquillization.
Semen Persicae: bitter but sweet flavor, property is put down, is entered the heart, liver, large intestine channel.[effect] removing blood stasis blood stasis expelling, moisturizes laxation.
Cortex Acanthopancis: acrid in the mouth, micro-hardship, warm in nature.[effect] has replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of strengthening the body resistance.
Mel: lung moistening is quenched the thirst, looks improving and the skin nourishing, loosening bowel to relieve constipation, for a long time take anticancer.
Usage and dosage: once a day, each 10-20ml.
Advantages of the present invention and good effect:
(1) the raw materials used health of the present invention, safety, to human non-toxic's side effect；It is selected to treat hypertension, hyperlipidemia Medicine so that it is jointly play therapeutical effect.Meanwhile, by tonification biological organs, it is ensured that they are able to maintain that at optimal shape State, plays the effect of assisting in preventing and treating so that it is the most effective for severe hypertension, hyperlipemic patients.Long-term taking, can not only Play reduce blood pressure, the effect of blood fat, additionally it is possible to effectively facilitate health equilibrium between yin and yang, it is provided that body function.
(2) raw material sweet in the mouth person of the present invention is in the majority, when making liquid oral medicine, and raising patient's compliance, good absorbing, Bioavailability is high, and preparation technology is simple.
Blood pressure lowering of the present invention, fall is proved below by using essential hypertension and acute high blood lipid model and clinical data The action effect of fat.
One, essential hypertension and acute high blood lipid model experimental data
1 materials and methods
1.1 laboratory animal
Original hypertensive rat (SHR): be purchased from Beijing Vital River Experimental Animals Technology Co., Ltd.；Kunming kind is little Mus, male and female half and half, body weight 19～21g, preclinical medicine institute of Jilin University animal experimental center provide.
1.2 medicines and reagent
The drink of the embodiment of the present invention 4.Blood pressure lowering 0: Beijing Double-Crane Pharmaceutical Co., Ltd.Zhibituo: Chengdu buchu Nine deep pharmaceutical factories.
1.3 instrument
RBP-1 type not damaged rat tail artery analyzer；752 type spectrophotometers.
The impact on original hypertensive rat (SHR) blood pressure of 1.4 embodiment 4 drinks
Taking original hypertensive rat 40, male and female half and half, after adapting to 1 week in fixed environment, by the big rat-tail of not damaged Tremulous pulse measuring cell surveys its blood pressure as value before medicine.By blood pressure and body weight, animal being divided into 5 groups, packet and dosage are shown in Table 1, often Day 1 time, totally 20 days.Observe the impact on original hypertensive rat blood pressure of each dosage medicine.
The impact on chmice acute high blood lipid model of 1.5 embodiment 4 drinks
Take 72 mices, female, body weight 19～21g, it is grouped and is administered and be shown in Table 2, every day 1 time, totally 5 days.The 4th day gavage It is administered latter 1 hour, in addition to blank group, model group and the egg yolk emulsion (0.5ml of each administration equal lumbar injection of group mice 75% Only).Meanwhile, water is can't help in fasting, and after 16 hours, i.e. mice sacrificed by decapitation is taken serum, surveys its cholesterol by last administration for latter 1 hour (TC), triglyceride (TG) and high density lipoprotein (HDL) content.
1.6 statistical analysis data withRepresent, between group, compare employing t inspection.
2 results
2.1 embodiment 4 drinks are shown in Table 1 to the impact of original hypertensive rat blood pressure
Table 1 embodiment 4 drink on the impact of original hypertensive rat blood pressure (Kpa, n=8)
P < 0.05 P < 0.01 (lower same) is compared with blank group
Continued 1 embodiment 4 drink on the impact of original hypertensive rat blood pressure (Kpa, n=8)
The drink of continuous upper table embodiment 4 on the impact of original hypertensive rat blood pressure (Kpa, n=8)
The drink of 2.2 embodiments 4 is shown in Table 2 to the impact of chmice acute high blood lipid model
The impact on chmice acute high blood lipid model of the drink of table 2 embodiment 4
P < 0.05 P < 0.01 is compared with model group
Conclusion: knowable to table 1, table 2, drink of the present invention can substantially reduce the blood pressure of original hypertensive rat, Significantly reduce the T-CHOL of hyperlipidemic mice and the content of triglyceride simultaneously.
Two, clinical data
1, case selection
In 113 examples, male 86 examples, female 27 example；Minimum 37 years old of age, maximum 71 years old, with 45-65 year for many, account for 72%；Shrink Pressure is all at more than 22kPa, and diastolic pressure is all at more than 14.8kPa.This organizes II phase hypertension 74 example, and III phase hypertension 39 example, without continuing Essential hypertension or malignant hypertension patient.This group case serum cholesterol is all in more than 6.76mmol/L (normal value 2.9- 6.0mmol/L)；Triglyceride raises (normal value 0.22-1.2mmol/L) the most accordingly.
2, Therapeutic Method
Before selecting to use drink of the present invention, disable other hypertension and hyperlipemia medicines 2 weeks, detect blood pressure, blood fat, treatment Later stage checks blood pressure, blood fat again, to compare.Taking every day period 1 time, each 15ml, taking 30 days is a course for the treatment of.
3, result
This group patient is after the drink of the present invention is treated, and blood pressure is decreased obviously, and shrinks pressure average before 113 example patient treatments 26.1kPa, average 20.6kPa after treatment, equal value difference declines 5.5kPa；Diastolic pressure average 17.1kPa before treatment, average after treatment 13.7kPa, equal value difference declines 3.4kPa.
In blood fat gallbladder solid the most liquor-saturated all have with triglyceride decline by a relatively large margin；Average before 113 example total serum cholesterol in patients treatments 7.72mmol/L, average 5.45mmol/L after treatment, equal value difference 2.27mmol/L.Average 1.79mmol/ before triglyceride treatment L, all grows after treatment for 1.08mmol/L, equal value difference 0.71mmol/L.Before and after treatment, own control compares p < 0.01.
Detailed description of the invention
Embodiment 1
(1) Radix Puerariae 10 weight portion, Rhizoma Polygonati 10 weight portion, Fructus Lycii 4 weight portion, Rhizoma Polygonati Odorati 2 weight portion, Fructus Citri Sarcodactylis 2 weight are weighed Part, Herba Oxytropis Psammocharitis 5 weight portion, the Radix Angelicae Dahuricae 8 weight portion, Arillus Longan 10 weight portion, Fructus Mume 5 weight portion, Fructus Rubi 6 weight portion, Bulbus Lilii 2 weight Amount part, Semen Persicae 8 weight portion, Cortex Acanthopancis 5 weight portion, Cordyceps militaris (L.) Link.sporophore 5 weight portion, pulverize, uniformly mix, put Multifunction hand Taking in tank, after soaking 5 hours, heating decocts three times, adds the water of medical material 10 times amount for the first time, and decocting time is 2 hours, for the second time Adding the water of medical material 8 times amount, decoct 1.5 hours, third time adds the water of medical material 6 times amount, decocts 1 hour, every time mistake respectively after decoction 120 eye mesh screens, leaching medicinal liquid, three medicinal liquids are uniformly mixed；Mixed medicinal liquid is put in settling tank, staticly settles 24 little Time, in taking settling tank, upper clear liquid medicine, standby；
(2) weigh Colla Corii Asini 10 weight portion, pulverize；Take the purification water of Colla Corii Asini 1 times amount again, be heated to 40-60 DEG C, by pulverize Colla Corii Asini is added to the water, stirring while adding, and stir to obtain Colla Corii Asini liquid；
(3) weigh earthworm protein 5 weight portion, nicotinic acid 8 weight portion, grind in being placed in mortar, obtained the fine powder of 200 mesh, Standby；
(4) step (1), step 2, the medicinal liquid of step 3, Colla Corii Asini liquid and fine powder are mixed, add 15 weight portions Mel, stirring, mix homogeneously, fill, sterilizing.
Embodiment 2
(1) Radix Puerariae 15 weight portion, Rhizoma Polygonati 7 weight portion, Fructus Lycii 8 weight portion, Rhizoma Polygonati Odorati 1 weight portion, Fructus Citri Sarcodactylis 6 weight are weighed Part, Herba Oxytropis Psammocharitis 1 weight portion, the Radix Angelicae Dahuricae 12 weight portion, Arillus Longan 5 weight portion, Fructus Mume 8 weight portion, Fructus Rubi 2 weight portion, Bulbus Lilii 4 weight Amount part, Semen Persicae 6 weight portion, Cortex Acanthopancis 10 weight portion, Cordyceps militaris (L.) Link.sporophore 1 weight portion, pulverize, uniformly mix, put multi-functional In extraction pot, after soaking 4 hours, heating decocts three times, adds the water of medical material 10 times amount for the first time, and decocting time is 2 hours, and second The secondary water adding medical material 8 times amount, decocts 1.5 hours, and third time adds the water of medical material 6 times amount, decocts 1 hour, after decocting respectively every time Cross 120 eye mesh screens, leaching medicinal liquid, three medicinal liquids are uniformly mixed；Mixed medicinal liquid is put in settling tank, staticly settles 24 little Time, in taking settling tank, upper clear liquid medicine, standby；
(2) weigh Colla Corii Asini 7 weight portion, pulverize；Take the purification water of Colla Corii Asini 1 times amount again, be heated to 40-60 DEG C, by pulverize Colla Corii Asini is added to the water, stirring while adding, and stir to obtain Colla Corii Asini liquid；
(3) weigh earthworm protein 1 weight portion, nicotinic acid 5 weight portion, grind in being placed in mortar, obtained the fine powder of 200 mesh, Standby；
(4) step (1), step 2, the medicinal liquid of step 3, Colla Corii Asini liquid and fine powder are mixed, add 19 weight portions Mel, stirring, mix homogeneously, fill, sterilizing.
Embodiment 3
(1) Radix Puerariae 15 weight portion, Rhizoma Polygonati 5 weight portion, Fructus Lycii 4 weight portion, Rhizoma Polygonati Odorati 2 weight portion, Fructus Citri Sarcodactylis 4 weight are weighed Part, Herba Oxytropis Psammocharitis 3 weight portion, the Radix Angelicae Dahuricae 10 weight portion, Arillus Longan 8 weight portion, Fructus Mume 10 weight portion, Fructus Rubi 5 weight portion, Bulbus Lilii 6 Weight portion, Semen Persicae 8 weight portion, Cortex Acanthopancis 7 weight portion, Cordyceps militaris (L.) Link.sporophore 3 weight portion, pulverize, uniformly mix, put multi-functional In extraction pot, after soaking 3 hours, heating decocts three times, adds the water of medical material 10 times amount for the first time, and decocting time is 2 hours, and second The secondary water adding medical material 8 times amount, decocts 1.5 hours, and third time adds the water of medical material 6 times amount, decocts 1 hour, after decocting respectively every time Cross 120 eye mesh screens, leaching medicinal liquid, three medicinal liquids are uniformly mixed；Mixed medicinal liquid is put in settling tank, staticly settles 24 little Time, in taking settling tank, upper clear liquid medicine, standby；
(2) weigh Colla Corii Asini 5 weight portion, pulverize；Take the purification water of Colla Corii Asini 1 times amount again, be heated to 40-60 DEG C, by pulverize Colla Corii Asini is added to the water, stirring while adding, and stir to obtain Colla Corii Asini liquid；
(3) weigh earthworm protein 3 weight portion, nicotinic acid 3 weight portion, grind in being placed in mortar, obtained the fine powder of 200 mesh, Standby；
(4) step (1), step 2, the medicinal liquid of step 3, Colla Corii Asini liquid and fine powder are mixed, add 15 weight portions Mel, stirring, mix homogeneously, fill, sterilizing.
Embodiment 4
(1) Radix Puerariae 13 weight portion, Rhizoma Polygonati 10 weight portion, Fructus Lycii 6 weight portion, Rhizoma Polygonati Odorati 1 weight portion, Fructus Citri Sarcodactylis 6 weight are weighed Part, Herba Oxytropis Psammocharitis 5 weight portion, the Radix Angelicae Dahuricae 10 weight portion, Arillus Longan 7 weight portion, Fructus Mume 5 weight portion, Fructus Rubi 4 weight portion, Bulbus Lilii 3 weight Amount part, Semen Persicae 5 weight portion, Cortex Acanthopancis 7 weight portion, Cordyceps militaris (L.) Link.sporophore 3 weight portion, pulverize, uniformly mix, put Multifunction hand Taking in tank, after soaking 5 hours, heating decocts three times, adds the water of medical material 10 times amount for the first time, and decocting time is 2 hours, for the second time Adding the water of medical material 8 times amount, decoct 1.5 hours, third time adds the water of medical material 6 times amount, decocts 1 hour, every time mistake respectively after decoction 120 eye mesh screens, leaching medicinal liquid, three medicinal liquids are uniformly mixed；Mixed medicinal liquid is put in settling tank, staticly settles 24 little Time, in taking settling tank, upper clear liquid medicine, standby；
(2) weigh Colla Corii Asini 6 weight portion, pulverize；Take the purification water of Colla Corii Asini 1 times amount again, be heated to 40-60 DEG C, by pulverize Colla Corii Asini is added to the water, stirring while adding, and stir to obtain Colla Corii Asini liquid；
(3) weigh earthworm protein 3 weight portion, nicotinic acid 6 weight portion, grind in being placed in mortar, obtained the fine powder of 200 mesh, Standby；
(4) step (1), step 2, the medicinal liquid of step 3, Colla Corii Asini liquid and fine powder are mixed, add 19 weight portions Mel, stirring, mix homogeneously, fill, sterilizing.

Claims (3)

1. a blood fat-reducing blood pressure-decreasing drink, it is characterised in that: described drink is made up of the raw material of following weight parts: Radix Puerariae 10-15 part, Rhizoma Polygonati 5-10 part, Fructus Lycii 4-8 part, Rhizoma Polygonati Odorati 1-2 part, Fructus Citri Sarcodactylis 2-6 part, Herba Oxytropis Psammocharitis 1-5 part, Radix Angelicae Dahuricae 8-12 part, Arillus Longan 5-10 Part, Fructus Mume 5-10 part, Fructus Rubi 2-6 part, Bulbus Lilii 2-6 part, Semen Persicae 4-8 part, Cortex Acanthopancis 5-10 part, Cordyceps militaris (L.) Link.sporophore 1-5 Part, Colla Corii Asini 5-10 part, earthworm protein 1-5 part, nicotinic acid 3-8 part, Mel 15-20 part.
A kind of blood fat-reducing blood pressure-decreasing drink the most according to claim 1, it is characterised in that: former by following weight parts of described drink Material is made: Radix Puerariae 13 parts, Rhizoma Polygonati 10 parts, Fructus Lycii 6 parts, Rhizoma Polygonati Odorati 1 part, Fructus Citri Sarcodactylis 6 parts, Herba Oxytropis Psammocharitis 5 parts, the Radix Angelicae Dahuricae 10 parts, Arillus Longan 7 Part, Fructus Mume 5 parts, Fructus Rubi 4 parts；Bulbus Lilii 3 parts, 5 parts of Semen Persicae, Cortex Acanthopancis 7 parts, Cordyceps militaris (L.) Link.sporophore 3 parts, 6 parts of Colla Corii Asini, Pheretima 3 parts of albumen, 6 parts of nicotinic acid, Mel 19 parts.
3. the preparation method of a blood fat-reducing blood pressure-decreasing drink, it is characterised in that: comprise the following steps:
(1) weigh the Radix Puerariae of described weight portion, Rhizoma Polygonati, Fructus Lycii, Rhizoma Polygonati Odorati, Fructus Citri Sarcodactylis, Herba Oxytropis Psammocharitis, the Radix Angelicae Dahuricae, Arillus Longan, Fructus Mume, cover Basin, Bulbus Lilii, Semen Persicae, Cortex Acanthopancis, Cordyceps militaris (L.) Link.sporophore, pulverize, uniformly mix, put in multi-function extractor, soaks 3-5 little Shi Hou, heating decocts three times, and each amount of water is medical material amount 6-10 times, and each decocting time is 1-2 hour；Cross 120 mesh by several times Screen cloth, leaching medicinal liquid, it is mixed；Medicinal liquid is put in settling tank, staticly settle more than 12 hours；In taking settling tank, upper clear liquid medicine, standby With；
(2) weigh the Colla Corii Asini of described weight portion, pulverize；Take the purification water of Colla Corii Asini amount 1 times again, be heated to 40-60 DEG C, add and pulverize Colla Corii Asini, stirring while adding, stir to obtain Colla Corii Asini liquid；
(3) weigh the earthworm protein of described weight portion, nicotinic acid, grind in being placed in mortar, obtained the fine powder of 200 mesh, standby；
(4) step (1), step (2), the medicinal liquid of step (3), Colla Corii Asini liquid and fine powder are mixed, add described weight portion Mel, stirring, mix homogeneously, fill, sterilizing.
CN201610340261.7A 2016-05-20 2016-05-20 Oral liquid with lipid-decreasing and pressure-decreasing effects and preparation method thereof Pending CN105998639A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107212129A (en) * 2017-06-23 2017-09-29 禹州市鼎信中药科技有限公司 A kind of peach kernel Sessileflower Acanthopanax Bark alternative tea
CN108186870A (en) * 2018-03-15 2018-06-22 天津白大夫健康管理有限公司 Ginseng oyster particle

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Publication number Priority date Publication date Assignee Title
CN101797341A (en) * 2010-04-22 2010-08-11 宋长现 Chinese herbal medicine pill capable of clearing blood fat and lowering blood pressure
CN104784473A (en) * 2015-03-10 2015-07-22 贵州广济堂药业有限公司 Earthworm protein health care product

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101797341A (en) * 2010-04-22 2010-08-11 宋长现 Chinese herbal medicine pill capable of clearing blood fat and lowering blood pressure
CN104784473A (en) * 2015-03-10 2015-07-22 贵州广济堂药业有限公司 Earthworm protein health care product

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107212129A (en) * 2017-06-23 2017-09-29 禹州市鼎信中药科技有限公司 A kind of peach kernel Sessileflower Acanthopanax Bark alternative tea
CN108186870A (en) * 2018-03-15 2018-06-22 天津白大夫健康管理有限公司 Ginseng oyster particle

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