CN108187020A - A kind of preparation method of Chinese medicine preparation and its application in vertigo is treated - Google Patents

A kind of preparation method of Chinese medicine preparation and its application in vertigo is treated Download PDF

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CN108187020A
CN108187020A CN201810237942.XA CN201810237942A CN108187020A CN 108187020 A CN108187020 A CN 108187020A CN 201810237942 A CN201810237942 A CN 201810237942A CN 108187020 A CN108187020 A CN 108187020A
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chinese medicine
concentrate
medicine preparation
preparation
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唐农
吴林
李学坚
蒋凌风
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Guangxi University of Chinese Medicine
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Guangxi University of Chinese Medicine
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296Epimedium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/746Morinda
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888Pinellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

Preparation method and its application in vertigo is treated, the Chinese medicine preparation the invention discloses a kind of Chinese medicine preparation are prepared from the following raw materials in parts by weight:25~35 parts of radix aconiti lateralis preparata, 10~20 parts of rhizoma zingiberis, 10~20 parts of Morinda officinalis, 10~20 parts of cassia twig, 10~20 parts of rhizoma pinellinae praeparata, 10~20 parts of grass-leaved sweetflag, 10~20 parts of Radix Notoginseng, 10~20 parts of Herba Epimedii, 10~20 parts of sun-dried ginseng, 3~9 parts of rheum officinale.The Chinese medicine preparation can effectively treat vertigo caused by a variety of diseases, master is adjusted within its therapy is main, fundamentally improve the nerve dysfunction phenomenon of patient, the generation of other major diseases such as prevention of cardiovascular disease, cranial vascular disease, apoplexy can be also cooperateed with, there is temperature to help Yuanyang, heat-clearing eliminating the phlegm, liver-kidney tonifying, dampness elimination appetizing, the heart restoring consciouness that disappears, adjust immune function and other effects.

Description

A kind of preparation method of Chinese medicine preparation and its application in vertigo is treated
Technical field
The present invention relates to field of traditional Chinese, the preparation method of specifically a kind of Chinese medicine preparation and its in vertigo is treated Application.
Background technology
Vertigo(Vertigo)It is a kind of dynamic property or positional illusion because body to being generated during planotopokinesia, hair Be characterized in usually feeling dizzy when making dizzy or even Nausea and vomiting can be generated, emit the vegetative dystonies such as cold sweat Shape.Dizziness can be divided into true vertigo and nonsystemic vertigo.True vertigo is as caused by eye, proprioceptive sensation or vestibular system disease, is had Apparent foreign object or itself sense of rotation.Nonsystemic vertigo is mostly caused by whole body system disease, such as angiocardiopathy, cerebrovascular disease Disease, anaemia, uremia, drug poisoning, endocrine system disease and neurosis etc. nearly all have the dizziness of weight not etc., suffer from Person feels " fluttering is swung ", without clearly rotation sense.According to statistics, vertigo annual loading calculates the whole nation 13 5% or so accordingly There are about 65,000,000 people in hundred million populations to suffer from dizziness or dizziness.Vertigo accounts for the 5% of outpatients in internal medicine clinics, accounts for hals,Nasen und Ohrenheilkunde outpatient service 15%.Dizziness is a kind of frequently-occurring disease, common disease, and is difficult and complicated illness, and also many unknown numbers are more common in the middle-aged and the old, also may be used Send out in young people, can recurrent exerbation, severe patient can develop into apoplexy, faint card or the exhaustion of vital energy at the critical stage of an illness and threat to life.
Dizziness clinically is prevented with traditional Chinese medicine, to controlling the generation of dizziness, development that there is good therapeutic effect.Dizziness position exists Clear key causes brains hollow by deficiency of qi and blood, kidney essence deficiency, YANG-orifices failing to be nourished or liver-yang hyperactivity, convulsive seizure due to phlegm-fire superinverse, obstruction of the orifices by blood stasis and disturb Dizziness occurs for dynamic clear key, dirty in close relations with liver,spleen,kidney three.In the pathogenic process of vertigo, various etiology and pathogenesis, Ke Yixiang It mutually influences, mutually converts, form simulataneous insufficiency and excessive;Or yin deficiency affecting yang, it is yin-yang deficiency.Clear key is disturbed on liver wind, convulsive seizure due to phlegm-fire, is further developed It can go up and cover clear key, block channels and collaterals, and form apoplexy;Or burst qi-movement disturbance, clear key, which is temporarily closed or lost, supports, and causes syncope.
In recent years, dizziness was more and more paid close attention to by multiple subjects, using dizziness as special topic academic conference increasingly It is more.Dizziness is a kind of frequently-occurring disease, common disease, and is difficult and complicated illness, and there are many unknown numbers, dizziness is related to multiple subjects, with ear Nasopharynx larynx Head and neck tumour, Neurology, emergency department, Geriatrics Dept., orthopaedics etc. are more common.Drug about treatment dizziness at present It is palliative mostly all without obtaining the effect of fine although very much;Many masses still lack the basic knowledge of dizziness, This also leads to many phenomenon that patient does not choose the doctor, and so as to cause no good specific aim is treated, therapeutic effect is bad.
It also swoons the relevant technologies of disease about treatment brain in open source literature at present, such as:
1st, Chinese patent:A kind of Chinese medicine composition for treating vertigo;Application number:201410527251.5;The applying date:2014- 10-10;Applicant:Wang Shuqiang;Abstract:The present invention relates to a kind of Chinese medicine compositions for treating vertigo, are by following weight The Chinese medicine material composition of part proportioning:20-40 parts of red crowned crane, 10-30 parts of rhizoma alismatis, 20-40 parts of cassia twig, 20-40 parts of Poria cocos, rhizoma atractylodis 10- 30 parts, 5-20 parts of grass-leaved sweetflag, 20-40 parts of pueraria lobata, 10-30 parts of moutan bark, 10-30 parts of the radix paeoniae rubrathe, 3-10 parts of honey-fried licorice root.The present invention's Chinese medicine composition has plays the effect of playing beneficial spleen and stomach, slit phlegm of having one's ideas straightened out, warming meridians and promoting circulation of qi, promoting blood circulation to remove blood stasis altogether altogether, treats vertigo It is significant in efficacy, reliable effect.Its each component medicine source is wide, prepares easy, mild in medicine property and has no toxic side effect.
2nd, Chinese patent:A kind of Chinese medicine preparation for treating vertigo;Application number:201310074131.X;The applying date: 2013-03-08;Applicant:Fan Derun;Abstract:The invention discloses a kind of Chinese medicine preparation for treating vertigo, by following weight Chinese medicine material be made:RHIZONA GASTRODIAE 10-25g, Rhizoma Atractylodis Macrocephalae preparata 5-15g, selfheal 5-20g, Cassia occidentalis 5-15g, fructus viticis 5-15g, Fushen 5-15g, tuber of pinellia 5-15g processed, cypress jujube kernel each 5-15g, Radix Polygalae 5-15g, Radix Angelicae Sinensis 5-15g, stir-baked RADIX PAEONIAE ALBA 5-15g, stir-baked CORTEX EUCOMMIAE 5- 20g, dogwood fruit 5-15g, Ramulus Taxilli 5-20g, Radix Astragali 12-25g, rhizoma alismatis 5-15g, each 12-25g of Concha Ostreae.Prescription of the present invention closes Reason, it is convenient to take, it has no toxic side effect, can effectively treat various vertigo, it is ailing to eliminate patient.
3rd, Chinese patent:Treat the Chinese medicine of dizziness;Application number:201210446779.0;The applying date:2012-11-11;Shen It asks someone:Guo Yihui;Abstract:A kind of Chinese medicine for treating dizziness, it is characterised in that it includes the raw material of following weight proportion:The tuber of pinellia 15g;Rhizoma Atractylodis Macrocephalae 20g;Rhizoma Gastrodiae 15g;Cloud a kind of reed mentioned in ancient books 20g;Dried orange peel 15g;Rhizoma alismatis 40g;Ginger 15g;Radix Salviae Miltiorrhizae 30g;Radix Glycyrrhizae 5g;Pueraria lobata 30g;Chrysanthemum Flower 30g;Rhizoma Chuanxiong 20g.By adopting the above-described technical solution, the present invention has the advantage that:It has special efficacy to treatment dizziness Chinese herbal medicine, not only can antiemetic relieving fainting, moreover it is possible to adjust and restore globality nervous system, of low cost, Small side effects.
Invention content
A kind of preparation method the object of the present invention is to provide Chinese medicine preparation and its application in vertigo is treated, in this Medicine preparation can effectively treat vertigo caused by a variety of diseases, and master is adjusted within therapy is main, fundamentally improve and suffer from The nerve dysfunction phenomenon of person can also cooperate with the hair of other major diseases such as prevention of cardiovascular disease, cranial vascular disease, apoplexy It is raw, there is heat-clearing eliminating the phlegm, liver-kidney tonifying, dampness elimination appetizing, the heart restoring consciouness that disappears, adjust immune function and other effects.
The invention is realized by the following technical scheme:
The Chinese medicine preparation of vertigo is treated, is prepared from the following raw materials in parts by weight:25~35 parts of radix aconiti lateralis preparata, rhizoma zingiberis 10~20 Part, 10~20 parts of Morinda officinalis, 10~20 parts of cassia twig, 10~20 parts of rhizoma pinellinae praeparata, 10~20 parts of grass-leaved sweetflag, 10~20 parts of Radix Notoginseng are excessive 10~20 parts of the sheep leaves of pulse plants, 10~20 parts of sun-dried ginseng, 3~9 parts of rheum officinale;Preparation method includes the following steps:
(1)Radix Notoginseng and sun-dried ginseng are weighed by weight ratio, is crushed to 4~24 mesh, add in the ethyl alcohol that volume fraction is 60~80%, It carries out refluxing extraction 2~3 times, 1~2 hour every time, obtains alcohol extract and the alcohol extracting dregs of a decoction, recycle ethyl alcohol after alcohol extract filtering, obtain To concentrate A;
(2)Radix aconiti lateralis preparata, rhizoma zingiberis, Morinda officinalis, cassia twig, rhizoma pinellinae praeparata, grass-leaved sweetflag, Herba Epimedii and rheum officinale are weighed by weight ratio, are shredded, It is proportionally added into step(1)The alcohol extracting dregs of a decoction of gained extract 1~3 time, add in all 10~15 times of medicinal material dry weights every time Water boils 1~3 hour, and extraction while collects volatile oil, merges Aqueous extracts filtering, is concentrated, obtain concentrate B;
(3)Concentrate A and concentrate B is mixed, suitable Chinese medicine auxiliary material is added in, required pharmaceutical formulation is made.
Specifically, the radix aconiti lateralis preparata floated, boiled through salt marsh, water by black suitable piece, frying into.
The rheum officinale is the prepared RADIX ET RHIZOMA RHEI made of sorrel, Rheum tanguticum Maxim or Rheum officinale are through boiling, is prepared Method includes the following steps:Rhubarb is taken to be cut into small pieces, is mixed thoroughly with yellow rice wine, the weight ratio of rhubarb and yellow rice wine is 1:0.3~ 0.5, it puts and is steamed in food steamer 1~3 time, taking-up is dried up to prepared RADIX ET RHIZOMA RHEI.
Above-mentioned Chinese medicine preparation is in the application for preparing treatment dizziness disease drug, the drug including being prepared into following dosage form:It is oral Liquid, pill or soft extract.
The preparation method of the oral liquid is:Concentrate A and concentrate B are mixed, syrup is added in and adjusts mouthfeel, syrup by White granulated sugar and honey are according to 1:0.1~0.3 is made, and is sterilized, packed, you can obtained.
The preparation method of the pill is:Concentrate A and concentrate B is mixed, is concentrated in vacuo, adds in step(2)Gained Volatile oil, add in honey, gelatinized corn starch, xanthans are uniformly mixed, the pellet medicament that moisture is no more than 12% be made.
The preparation method of the soft extract is:Concentrate A and concentrate B are mixed, be concentrated into relative density 1.35~ 1.40;Refining syrup constant volume is added in, heating is tempered 1~2 hour, is controlled moisture loss, is made relative density in 1.38~1.42 models In enclosing, step is added in when being cooled to 60~80 DEG C(2)The volatile oil of gained adds in mouth feel modifying agents modulation mouthfeel, is sufficiently stirred, Vacuum suction eliminate bubble, dispense to get.
The characteristic of disease of dizziness is in the majority with empty person, such as the deficiency of liver-yin and kidney-yin, liver wind agitation, deficiency of qi and blood, YANG-orifices failing to be nourished, deficiency of kidney-essence, Brains mistake is filled;Dizziness real example is then mostly checked by phlegm is turbid, disturbance in ascending and descending, the convulsive seizure due to phlegm-fire circulation of vital energy in the wrong direction, upper to violate clear key, and hemostasis is at a stop, and numbness hinders clear key It forms.The Chinese medicine preparation for the treatment of vertigo of the present invention, principle of reatment are mainly qi-restoratives and rush down reality, adjust negative and positive.It is empty In the majority, the smart void person's replenishing essence life marrow that declines less with deficiency of kidney-essence, qi and blood is demonstrate,proved, it is nourishing liver and kidney;Asthenia of qi and blood person's nourishing qi and blood adjusts tonifying spleen kidney; Real example then using checking exuberance of yang, purging intense heat, resolving sputum, by the stasis of blood as main therapy.
It is as follows that Pharmacological Analysis is carried out to Chinese medicine of the present invention:
Radix aconiti lateralis preparata:The ranunculaceae plant rhizome of Chinese monkshood(Aconitum carmichaeli Debx.)Sub- root processed goods.It is pungent, sweet, greatly Heat;It belongs to the heart, kidney, spleen channel.Recuperating depleted yang, mends fire supporing yang, by wind-cold damp pathogen.It collapses for yang depletion, cold weak pulse of limb, impotence, Gong Leng, Trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, cold sensation of the genitalia oedema, deficiency of yang diseases caused by external factors, numbness and ache of cold dampness.Monkshood contains mesaconitine(mesaconitine), crow Head alkali(aconitine), Hypaconitine(hypaconitine), isoaconitine(isoaconitine), tower draw younger brother's amine (talatisamine), chuan-wu base A, second(chuan-wubaseA、B)Isoreactivity ingredient.Monkshood diterpene containing diester-type therein Alkaloid, such as aconitine, mesaconitine can become the smaller monoesters Alkaloid of toxicity through hydrolysis.
The rhizome of Chinese monkshood is ranunculaceae plant, and female root is the rhizome of Chinese monkshood, for antispastic, smelting wind low, rheumatism neuralgia;Lateral root(Sub- root)Enter Medicine is monkshood.The rhizome of Chinese monkshood is eliminating cold to stop pain key medicine, and the channels and collaterals that can not only dispel are cold, but also can to dissipate internal organs cold;There is Hui Yang, by cold, wind-damp dispelling Effect.Control loss of YANG due to profuse perspiration, four limbs faint the weak waist and knee crymodynia of inverse, choleraic myospasm, kidney yang, shape tremble with fear like cold, lassitude and The diseases such as wind-cold-dampness ache, tinea pedis.The high pressure steaming that the rhizome of Chinese monkshood is decocted or used recently long, can reduce toxicity.The rhizome of Chinese monkshood makes with other medicine compatibilities With such as rhizoma zingiberis, there is complementary effect, to strengthen power of its Wen Yang by cold analgesic.
Rhizoma zingiberis:Dry rhizome for zingiber Zingiber oj-jicinale Rosc..Also known as:Bai Jiang, equal ginger, Dry ginger.Acrid flavour, property heat.Returns spleen, stomach, kidney, the heart, lung channel.Warming spleen and stomach for dispelling cold, recover Yang and smooth venation, warming lung and resolving fluid.It is cold to be usually used in gastral cavity abdomen Bitterly, vomiting and diarrhea, cold weak pulse of limb, cold drink are breathed with cough.Jiang Hanyou gingerols, zingerone, gingerol isoreactivity ingredient have dispelling cold, dispel Wet, warm stomach accelerates the plurality of health care functions such as blood circulation.Gingerol has stimulation to oral cavity and gastric mucosa, can promote digestion Liquid is secreted, and is improved a poor appetite, and can make intestines tension, the rhythm and pace of moving things and wriggle to increase;Zingerone has excited work to breathing and vasomotor center With can promote blood circulation, stomach invigorating, refresh oneself, restoring consciouness.
There are some researches prove, ginger dry powder to the symptoms effective percentage such as the headache of motion sickness, dizziness, Nausea and vomiting up to 90%, and Sustainable 4 hours of drug effect or more.It is civil with eat ginger carsickness-proof, it is seasick or patch nei guan point, have obvious effects on therefore and have The reputation of " panacea of vomitting ".Modern pharmacological studies have shown that the methanol or ether extract of rhizoma zingiberis have calm, analgesia, anti-inflammatory, preventing or arresting vomiting and short The temporarily effect of raising blood pressure;Water extract or volatile oil can be obviously prolonged thrombosis time;Alcohol extracting thing and its contained ginger are peppery Element and the peppery ketenes of ginger have significantly go out spiral shell and anti-schistosome function.
Morinda officinalis:Classification system Morinda officinalis How. are madder wort Morinda officinalis Morinda ojj:The dry root of icinalis How, alias Morinda offcinalis How, Ba Jitian.It is sweet in flavor, pungent, slightly warm in nature.Return kidney, Liver Channel.With kidney-replenishing, The effect of strengthening the bones and muscles, wind-damp dispelling.It is usually used in for impotence and seminal emission, uterus cold infertile, irregular menstruation, few abdomen crymodynia, arthralgia pain due to rheumatism, muscle The atrophic debility of bones is soft.
Cassia twig:Classification system CassiaTwig is the drying of canella Chinese cassia tree Cinnamomum cassia Presl Spray has special fragrance.Its nature and flavor acrid, sweet, warm, enters lung, the heart, bladder warp, is to cure mainly the common drugs for dispelling internal cold of interior cold, has complement The effect of sun, promoting blood circulation, warming spleen and stomach, often with tonifying liver renal drug, fill blood medicine compatibility, treatment the insufficiency of the kidney yang, the Yang-function insufficiency of kidneyzang, the cold arteries and veins of limb It is micro-, with other drugs for dispelling internal cold compatibilities treatment coldness and pain in the epigastrium, arthritis pain in the back, there is significantly analgesia and anti-cancer and cancer-preventing.
Rhizoma pinellinae praeparata:Classification system Rhizoma Pinelliae are aroid tuber of pinellia Pinellia ternata (Thunb) stem tuber of Breit.;Also known as:The tuber of pinellia processed, preparation method summer, system ground text, eight beans of system ground.It is pungent, warm;Returns spleen, stomach, lung channel.Work( It can cure mainly:It is eliminating dampness and eliminating phlegm;For abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, phlegm and headache.Rhizoma pinellinae praeparata can activate vagus nerve Efferent Activities and with anti-vomiting effect, moreover it is possible to inhibit pepsin activity, protect stomach lining, promote the reparation of stomach lining, have The effect of anti-rat pyloric ligation ulcer, indocin ulcer and stress ulcer.
Grass-leaved sweetflag:Classification system:Acorus tatarinowii belong to Araeceae, Acorus graminoid perennial herb Plant, rhizome are often made medicinal.Major function:Dampness elimination appetizing, slit phlegm of having one's ideas straightened out, inducing resuscitation intelligence development.For gastral cavity ruffian is not hungry, apnea, Coma epilepsy, forgetfulness and deafness.Qi-regulating, promoting blood circulation, relieve heat are dried.Control epilepsy, coma due to blocking of the respiratory system, pyreticosis coma, forgetful, deafness with qi stagnation, ambition It is unhappy.Volatile oil there are many containing in grass-leaved sweetflag, main component is beta-Asarone, cis- methyl tert-butyl sesame oil phenol, elemicine, Asarylaldehyde, the clear casket alkene of δ-Bi, Thymol and Pork and beans labour acid etc..Research shows that:Asarone in volatile oil is having for calmness Ingredient is imitated, soft extract made of grass-leaved sweetflag rhizome water extract is used clinically for treatment epileptics and other nervous system diseases Suffer from, there is good therapeutic effect, volatile oil has significant physiological activity to the animal model of certain nervous systems.Grass-leaved sweetflag decoction It is for oral administration to promote the secretion of digestive juice and prevent stomach and intestine abnormal fermentation, and play the role of alleviating intestinal tube smooth muscle spasm.
Radix Notoginseng:For the dry root and rhizome of panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen, Also known as:Pseudo-ginseng, Panax pseudoginseng, radix notoginseng, literary state Radix Notoginseng.Sweet, slight bitter, temperature.Return liver, stomach.Dissipate stasis of blood hemostasis, detumescence ding-tong.With It in spitting of blood, spits blood, bleeding from five sense organs or subcutaneous tissue is had blood in stool, uterine bleeding, traumatic hemorrhage, chest and abdomen shouting pain, tumbling and swelling.
Herba Epimedii:Scientific name:Epimedium brevicornu Maxim., Herba Epimedii acrid-sweet flavor is warm-natured, walks liver kidney two warp, For mend the gate of vitality, strengthening the essence gas, strengthening the bones and muscles, tonifying kidney and strengthening yang key medicine.Impotence and premature ejaculation is cured mainly, pain in low back and legs, numb limb, half body is not Then, neurasthenia, forgetful, tinnitus are dizzy to wait diseases.Pharmacological experiment study shows that Herba Epimedii can increase cardiovascular and cerebrovascular blood flow, promotees Into hematopoiesis function, immune function and bone metabolism, there is anti-aging, antitumor and other effects.
Modern research shows that Herba Epimedii containing icariine, volatile oil, ceryl alcohol, phytosterol, tannin, vitamin E etc. into Point.The excited sexual performance of energy, has animal and promotes gonopoiesis effect.Also it is depressured(Cause peripheral vasodilation), it is hypoglycemic, sharp Urine, kobadrin and the effect of vitamin E sample.Pharmacological experiment study shows that Herba Epimedii can increase cardiovascular and cerebrovascular blood flow, promotes Hematopoiesis function, immune function and bone metabolism have anti-aging, antitumor and other effects.
Sun-dried ginseng:It is dug out together with fibrous root by ginseng Panax ginseng C. A. Mey, cleared soil dries obtained. Sweet in flavor, slight bitter, it is warm-natured, flat.Returns spleen, lung channel, the heart channel of Hang-Shaoyin.Tonifying Qi, prevent prolapse are promoted the production of body fluid, and are calmed the nerves, intelligence development.The fleshy root of ginseng is famous Strong tonic suitable for adjustment blood pressure, restores cardiac function, neurasthenia and the diseases such as in poor health, also have eliminating the phlegm, stomach invigorating, Diuresis, excitement and other effects.
Rheum officinale:For polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Maxim Rheum tanguticum The drying root and rhizome of Maxim.ex Balf. or Rheum officinale Rheum officinale Baill..Autumn end cauline leaf wither or Secondary spring is excavated before germinateing, and removes radicula, scrapes off crust, valve cutting or section, and rope wears bunchiness drying or convection drying.With attack it is stagnant, Clearing away damp-heat, purging intense heat, cool blood, dissolving stasis, removing toxic substances and other effects.
The beneficial effects of the invention are as follows:
1st, it is of the present invention treatment vertigo Chinese medicine preparation, use pure natural Chinese herbal medicine as raw material, formula combination by Guangxi University of Chinese Medicine intends through clinical test into each raw material therein, which mutually cooperates with, can play the role for the treatment of vertigo, right There is the effect of fine in vertigo caused by treating various diseases, while vertigo symptoms are eliminated, to human liver, kidney, the heart, Spleen, lung are improved comprehensively, from body interior prevent the generation of various major diseases.
2nd, the Chinese medicine preparation can effectively treat vertigo caused by a variety of diseases, and master is adjusted within therapy is main, Fundamentally improve the nerve dysfunction phenomenon of patient, improve blood circulation, can also cooperate with prevention of cardiovascular disease, the cerebrovascular The generation of other major diseases such as disease, apoplexy has liver-kidney tonifying, dampness elimination appetizing, the heart restoring consciouness that disappears, strengthening the essence gas, strengthening the bones and muscles, clear Hot eliminating the phlegm adjusts immune function and other effects.
3rd, the Chinese medicine preparation for the treatment of vertigo of the present invention, preparation process is simple, and raw material sources are wide, and drug uses Specification, Chinese medicine used exist《Pharmacopoeia of People's Republic of China》In it is on the books, the Chinese medicine preparation is convenient to take, is applicable in masses model It encloses extensively, specific aim is wide, can treat dizziness caused by various diseases, and to human body, nontoxic pair is made for use in the range of regulation amount With.
Specific embodiment
The present invention is introduced in order to more detailed, with reference to embodiment, the present invention will be further described.
Embodiment 1
The Chinese medicine preparation for the treatment of vertigo in the present embodiment, is prepared from the following raw materials in parts by weight:30 parts of radix aconiti lateralis preparata, rhizoma zingiberis 15 parts, 15 parts of Morinda officinalis, 14 parts of cassia twig, 14 parts of rhizoma pinellinae praeparata, 16 parts of grass-leaved sweetflag, 13 parts of Radix Notoginseng, 15 parts of Herba Epimedii, sun-dried ginseng 13 Part, 6 parts of rheum officinale.
Preparation method includes the following steps:
(1)Radix Notoginseng and sun-dried ginseng are weighed by weight ratio, and 4 mesh standard sieves can be crossed by being crushed to, and add in the second that volume fraction is 70% Alcohol, carries out refluxing extraction 2 times, 1.5 hours every time, obtains alcohol extract and the alcohol extracting dregs of a decoction, recycles ethyl alcohol after alcohol extract filtering, obtain Concentrate A;
(2)Radix aconiti lateralis preparata, rhizoma zingiberis, Morinda officinalis, cassia twig, rhizoma pinellinae praeparata, grass-leaved sweetflag, Herba Epimedii and rheum officinale are weighed by weight ratio, are shredded, It is proportionally added into step(1)The alcohol extracting dregs of a decoction of gained extract 3 times, add in the water of 15 times of its total weight for the first time, boil 2 hours, It adds in the water of 12 times of its total weight twice afterwards, boils every time 1.5 hours, extraction while collects volatile oil, merges Aqueous extracts mistake Filter, is concentrated, obtains concentrate B;
(3)Oral liquid is made in preparing craft according to drug, and preparation method includes:Concentrate A and concentrate B are mixed It closes, adds in volatile oil, add in the syrup constant volume that water content is 40% and adjust mouthfeel, syrup is by white granulated sugar and honey according to 1:0.1 system Into it is made to contain the traditional Chinese medicine ingredients of regulation content, is sterilized, packed, you can obtained.
Specifically, the radix aconiti lateralis preparata floated, boiled through salt marsh, water by black suitable piece, frying into.
The rheum officinale is the prepared RADIX ET RHIZOMA RHEI made of sorrel, Rheum tanguticum Maxim or Rheum officinale are through boiling, is prepared Method includes the following steps:Rhubarb is taken to be cut into small pieces, is mixed thoroughly with yellow rice wine, the weight ratio of rhubarb and yellow rice wine is 1:0.4, put steaming It is steamed in cage 2 times, taking-up is dried up to prepared RADIX ET RHIZOMA RHEI.
Embodiment 2
A kind of Chinese medicine preparation for treating vertigo, is prepared from the following raw materials in parts by weight:30 parts of radix aconiti lateralis preparata, 16 parts of rhizoma zingiberis, bar 14 parts of halberd day, 15 parts of cassia twig, 15 parts of rhizoma pinellinae praeparata, 17 parts of grass-leaved sweetflag, 15 parts of Radix Notoginseng, 15 parts of Herba Epimedii, 17 parts of sun-dried ginseng, rheum officinale 6 Part.
Preparation method includes the following steps:
(1)Radix Notoginseng and sun-dried ginseng are weighed by weight ratio, and 10 mesh standard sieves can be crossed by being crushed to, and add in the second that volume fraction is 75% Alcohol, carries out refluxing extraction 2 times, 2 hours every time, obtains alcohol extract and the alcohol extracting dregs of a decoction, recycles ethyl alcohol after alcohol extract filtering, obtain dense Contracting liquid A;
(2)Radix aconiti lateralis preparata, rhizoma zingiberis, Morinda officinalis, cassia twig, rhizoma pinellinae praeparata, grass-leaved sweetflag, Herba Epimedii and rheum officinale are weighed by weight ratio, are crushed To 60 mesh, it is proportionally added into step(1)The alcohol extracting dregs of a decoction of gained extract 2 times, add in the water of 15 times of its total weight for the first time, boil Boiling 2 hours, adds in the water of 12 times of its total weight, boils 2 hours for the second time, and extraction while collects volatile oil, merges Aqueous extracts Filtering, is concentrated, obtains concentrate B;
(3)Pill is made in preparing craft according to drug, and preparation method includes:Concentrate A and concentrate B is mixed, It is concentrated in vacuo, adds in volatile oil, add in honey, gelatinized corn starch, xanthans and be uniformly mixed, the ball powder that moisture is 10% is made Agent.
Specifically, the radix aconiti lateralis preparata floated, boiled through salt marsh, water by black suitable piece, frying into.
The rheum officinale is the prepared RADIX ET RHIZOMA RHEI made of sorrel, Rheum tanguticum Maxim or Rheum officinale are through boiling, is prepared Method includes the following steps:Rhubarb is taken to be cut into small pieces, is mixed thoroughly with yellow rice wine, the weight ratio of rhubarb and yellow rice wine is 1:0.4, put steaming It is steamed in cage 2 times, taking-up is dried up to prepared RADIX ET RHIZOMA RHEI.
Embodiment 3
A kind of Chinese medicine preparation for treating vertigo, is prepared from the following raw materials in parts by weight:30 parts of radix aconiti lateralis preparata, 18 parts of rhizoma zingiberis, bar 14 parts of halberd day, 16 parts of cassia twig, 15 parts of rhizoma pinellinae praeparata, 15 parts of grass-leaved sweetflag, 15 parts of Radix Notoginseng, 14 parts of Herba Epimedii, 13 parts of sun-dried ginseng, rheum officinale 5 Part.
Preparation method includes the following steps:
(1)Radix Notoginseng and sun-dried ginseng are weighed by weight ratio, and 20 mesh standard sieves can be crossed by being crushed to, and add in the second that volume fraction is 70% Alcohol, carries out refluxing extraction 3 times, 1 hour every time, obtains alcohol extract and the alcohol extracting dregs of a decoction, recycles ethyl alcohol after alcohol extract filtering, obtain dense Contracting liquid A;
(2)Radix aconiti lateralis preparata, rhizoma zingiberis, Morinda officinalis, cassia twig, rhizoma pinellinae praeparata, grass-leaved sweetflag, Herba Epimedii and rheum officinale are weighed by weight ratio, are shredded, It is proportionally added into step(1)The alcohol extracting dregs of a decoction of gained extract 3 times, add in the water of 15 times of its total weight for the first time, boil 2 hours, It adds in the water of 10 times of its total weight twice afterwards, boils every time 1.5 hours, extraction while collects volatile oil, merges Aqueous extracts mistake Filter, is concentrated, obtains concentrate B;
(3)Soft extract is made in preparing craft according to drug, and preparation method includes:Concentrate A and concentrate B are mixed It closes, is concentrated into relative density 1.38;Refining syrup constant volume is added in, heating is tempered 2 hours, is controlled moisture loss, is made relative density In the range of 1.40,4 mesh standard sieves can be crossed by, which being crushed to when being cooled to 70 DEG C, adds in mouth feel modifying agents modulation mouthfeel, is sufficiently stirred, Vacuum suction eliminate bubble, dispense to get.
Specifically, the radix aconiti lateralis preparata floated, boiled through salt marsh, water by black suitable piece, frying into.
The rheum officinale is the prepared RADIX ET RHIZOMA RHEI made of sorrel, Rheum tanguticum Maxim or Rheum officinale are through boiling, is prepared Method includes the following steps:Rhubarb is taken to be cut into small pieces, is mixed thoroughly with yellow rice wine, the weight ratio of rhubarb and yellow rice wine is 1:0.5, it puts It is steamed in food steamer 3 times, taking-up is dried up to prepared RADIX ET RHIZOMA RHEI.
According to Chinese medicine preparation made from the method for the invention, find that therapeutic effect is notable for clinical test, here is Typical case.Following case is used to illustrate this patent for treating the effect of dizziness, it is not limited to be used only for example Illness in son.
(1)Treatment to cervical vertigo.32 dizziness clinical patients for suffering from Carotid Sclerosis are selected, embodiment 1 is taken and makes The oral liquid obtained, totally 14 days.The results show that there are 27 effectively(Effective percentage 84.37%), the receipts of medication treatment posterior neck vertebral artery Before contracting peak blood flow velocity, mean blood flow velocity and blood flow speed at the end of vasodilation are higher than treatment;Its whole blood viscosity, blood plasma specific viscosity, Before packed cell volume, erythrocyte aggregation index and fibrinogen content are below treatment;Its vertigo symptoms disappears, and can normally give birth to It is living.
(2)Treatment to motion sickness.12 are selected to ride carsick adults all occurred every time, male 4, woman's property 8, Age 25-50 Sui takes pill made from embodiment 2, totally 10 days.In half a year after medication, at any time, arbitrarily amount to by bus 36 times.The results show that by bus when dizziness headache, nausea and vomiting or weak drowsiness frequency be 4 times.Show good control Treat motion sickness effect.
(3)Treatment to cerebral vertigo.Patients with vertigo 52 of the choosing with cerebral atherosclerosis, male 30, women 22, age 60-75 Sui is randomly divided into control group, dosing group, every group 26 each 15 male 11 female, the course for the treatment of 14 days.Control group is given Conventional therapy, dosing group add soft extract made from embodiment 3 in addition to using the conventional therapy identical with control group.Conventional group There are 13 vertigo symptoms to disappear(50%), 6 vertigo symptoms mitigations(23.07%), total effective rate 73.07%;Dosing group have 17 it is dizzy Dizzy symptom disappears(65.38%), 5 vertigo symptoms mitigations(19.23%), total effective rate 84.61%.The therapeutic effect of dosing group is bright It is aobvious better than conventional group.

Claims (7)

1. a kind of Chinese medicine preparation, which is characterized in that be prepared from the following raw materials in parts by weight:25~35 parts of radix aconiti lateralis preparata, rhizoma zingiberis 10 ~20 parts, 10~20 parts of Morinda officinalis, 10~20 parts of cassia twig, 10~20 parts of rhizoma pinellinae praeparata, 10~20 parts of grass-leaved sweetflag, Radix Notoginseng 10~20 Part, 10~20 parts of Herba Epimedii, 10~20 parts of sun-dried ginseng, 3~9 parts of rheum officinale;Preparation method includes the following steps:
(1)Radix Notoginseng and sun-dried ginseng are weighed by weight ratio, is crushed to 4~24 mesh, add in the ethyl alcohol that volume fraction is 60~80%, It carries out refluxing extraction 2~3 times, 1~2 hour every time, obtains alcohol extract and the alcohol extracting dregs of a decoction, recycle ethyl alcohol after alcohol extract filtering, obtain To concentrate A;
(2)Radix aconiti lateralis preparata, rhizoma zingiberis, Morinda officinalis, cassia twig, rhizoma pinellinae praeparata, grass-leaved sweetflag, Herba Epimedii and rheum officinale are weighed by weight ratio, are shredded, It is proportionally added into step(1)The alcohol extracting dregs of a decoction of gained extract 1~3 time, add in all 10~15 times of medicinal material dry weights every time Water boils 1~3 hour, and extraction while collects volatile oil, merges Aqueous extracts filtering, is concentrated, obtain concentrate B;
(3)Concentrate A and concentrate B is mixed, suitable Chinese medicine auxiliary material is added in, required pharmaceutical formulation is made.
2. Chinese medicine preparation according to claim 1, which is characterized in that the radix aconiti lateralis preparata by black suitable piece through salt marsh, water drift, Boil, frying into.
3. Chinese medicine preparation according to claim 1, which is characterized in that the rheum officinale is especially big by sorrel, Tang's Gu Through prepared RADIX ET RHIZOMA RHEI made of boiling, preparation method includes the following steps yellow or Rheum officinale:Rhubarb is taken to be cut into small pieces, uses yellow rice wine It mixes thoroughly, the weight ratio of rhubarb and yellow rice wine is 1:0.3~0.5, it puts and is steamed in food steamer 1~3 time, taking-up is dried up to prepared RADIX ET RHIZOMA RHEI.
4. Chinese medicine preparation described in claim 1 is in the application for preparing treatment dizziness disease drug, which is characterized in that including being prepared into The drug of following dosage form:Oral liquid, pill or soft extract.
5. Chinese medicine preparation according to claim 4 is in the application for preparing treatment dizziness disease drug, which is characterized in that described The preparation method of oral liquid is:Concentrate A and concentrate B is mixed, adds in volatile oil, add in syrup constant volume and adjusts mouthfeel, Syrup is by white granulated sugar and honey according to 1:0.1~0.3 is made, and is sterilized, packed, you can obtained.
6. Chinese medicine preparation according to claim 4 is in the application for preparing treatment dizziness disease drug, which is characterized in that the ball The preparation method of agent is:Concentrate A and concentrate B is mixed, is concentrated in vacuo, adds in step(2)The volatile oil of gained adds in bee Honey, gelatinized corn starch, xanthans are uniformly mixed, and the pellet medicament that moisture is no more than 12% is made.
7. Chinese medicine preparation according to claim 4 is in the application for preparing treatment dizziness disease drug, which is characterized in that described to decoct The preparation method of paste is:Concentrate A and concentrate B is mixed, is concentrated into relative density 1.35~1.40;Add in refining syrup Constant volume, heating are tempered 1~2 hour, control moisture loss, relative density is made to be cooled to 60~80 in the range of 1.38~1.42 DEG C when add in step(2)The volatile oil of gained adds mouth feel modifying agents modulation mouthfeel, is sufficiently stirred, vacuum suction eliminates gas Bubble, dispense to get.
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