CN108187020A - A kind of preparation method of Chinese medicine preparation and its application in vertigo is treated - Google Patents

Abstract

Preparation method and its application in vertigo is treated, the Chinese medicine preparation the invention discloses a kind of Chinese medicine preparation are prepared from the following raw materials in parts by weight：25~35 parts of radix aconiti lateralis preparata, 10~20 parts of rhizoma zingiberis, 10~20 parts of Morinda officinalis, 10~20 parts of cassia twig, 10~20 parts of rhizoma pinellinae praeparata, 10~20 parts of grass-leaved sweetflag, 10~20 parts of Radix Notoginseng, 10~20 parts of Herba Epimedii, 10~20 parts of sun-dried ginseng, 3~9 parts of rheum officinale.The Chinese medicine preparation can effectively treat vertigo caused by a variety of diseases, master is adjusted within its therapy is main, fundamentally improve the nerve dysfunction phenomenon of patient, the generation of other major diseases such as prevention of cardiovascular disease, cranial vascular disease, apoplexy can be also cooperateed with, there is temperature to help Yuanyang, heat-clearing eliminating the phlegm, liver-kidney tonifying, dampness elimination appetizing, the heart restoring consciouness that disappears, adjust immune function and other effects.

Description

A kind of preparation method of traditional Chinese medicine preparation and its application in the treatment of vertigo

technical field

The invention relates to the field of traditional Chinese medicine preparations, in particular to a preparation method of traditional Chinese medicine preparations and its application in treating vertigo.

Background technique

Vertigo (Vertigo) is a kind of motion or positional illusion caused by the body's obstacle to spatial positioning. During the attack, it is characterized by dizziness often felt dizzy, and even nausea, vomiting, cold sweat and other symptoms of autonomic nervous system disorder. . Vertigo can be divided into true vertigo and false vertigo. True vertigo is caused by disorders of the ocular, proprioceptive, or vestibular systems, with a distinct sense of foreign objects or self-rotation. Pseudo-vertigo is mostly caused by systemic diseases, such as cardiovascular disease, cerebrovascular disease, anemia, uremia, drug poisoning, endocrine disease and neurosis, etc. Almost all of them have dizziness symptoms ranging from severity to severity, and patients feel "floating". Swing", there is no clear sense of rotation. According to statistics, the annual prevalence of vertigo is about 5%. Based on this, it is estimated that about 65 million people in the country's 1.3 billion population suffer from vertigo or dizziness. Vertigo accounts for 5% of internal medicine outpatient visits and 15% of otolaryngology outpatient visits. Vertigo is a kind of frequently-occurring, common, and intractable disease. There are still many unknowns. It is more common in middle-aged and elderly people, and it can also occur in young people. life threatening.

Clinically, traditional Chinese medicine is used to prevent and treat vertigo, which has a good curative effect on controlling the occurrence and development of vertigo. Vertigo is located in the clear orifices, and the clear orifices are disturbed by qi and blood deficiency, insufficient kidney essence, resulting in emptiness of the brain, loss of nourishment of the clear orifices, or hyperactivity of liver yang, phlegm fire, blood stasis, and disturbance of the clear orifices. The spleen and kidney are closely related. During the pathogenesis of vertigo, various etiology and pathogenesis can interact and transform each other to form a mixture of deficiency and excess; or yin deficiency and yang, and yin and yang deficiency. Liver wind and phlegm-fire disturb the clear orifices, and further development can lead to blindness and clear orifices, block the meridians, and cause stroke; or sudden qi movement disorder, temporary closure or loss of nourishment of the clear orifices, and fainting.

In recent years, vertigo has received more and more attention from multiple disciplines, and there are more and more academic conferences focusing on vertigo. Vertigo is a frequently-occurring, common, and difficult disease with many unknowns. Vertigo involves multiple disciplines, and it is more common in otolaryngology-head and neck surgery, neurology, emergency department, geriatrics, orthopedics, etc. Although there are many drugs for treating vertigo at present, most of them have not achieved good curative effect, and they treat the symptoms but not the root cause; many people still lack the basic knowledge of vertigo, which also leads to the phenomenon of many sick people going to the doctor indiscriminately, which leads to the lack of good treatment. Targeted, poor treatment effect.

There are also related technologies for the treatment of dizziness in the current open literature, such as:

1. Chinese patent: a traditional Chinese medicine composition for treating vertigo; application number: 201410527251.5; application date: 2014-10-10; applicant: Wang Shuqiang; abstract: the present invention relates to a traditional Chinese medicine composition for treating vertigo. It is composed of the following traditional Chinese medicine raw materials in the following proportions by weight: 20-40 parts of Crane, 10-30 parts of Alisma, 20-40 parts of Guizhi, 20-40 parts of Poria cocos, 10-30 parts of Atractylodes atractylodes, 5-20 parts of Shichangpu , 20-40 parts of kudzu root, 10-30 parts of Moutan bark, 10-30 parts of red peony root, 3-10 parts of roasted licorice. The traditional Chinese medicine composition of the invention has the effects of benefiting the spleen and harmonizing the stomach, resuscitating the mind and clearing the phlegm, warming the meridian and dredging the meridians, promoting blood circulation and dispelling blood stasis, and has remarkable curative effect and reliable effect on treating vertigo. The various components of the medicine have wide sources of medicine, are easy to prepare, have mild medicine properties, and have no toxic and side effects.

2. Chinese patent: a traditional Chinese medicine preparation for the treatment of vertigo; application number: 201310074131.X; application date: 2013-03-08; applicant: Fan Derun; abstract: the invention discloses a traditional Chinese medicine preparation for the treatment of vertigo, It is made of the following traditional Chinese medicine raw materials: 10-25g of Astragalus, 5-15g of Jiaobaizhu, 5-20g of Prunella vulgaris, 5-15g of Cassia officinalis, 5-15g of Vitex, 5-15g of Fushen, and Zhipinellia 5-15g, Baizaoren 5-15g each, Polygala 5-15g, Angelica 5-15g, fried white peony 5-15g, fried Eucommia 5-20g, cornus 5-15g, mulberry 5-20g, astragalus 12 -25g, Alisma 5-15g, raw Longmu 12-25g each. The composition of the invention is reasonable, convenient to take, and has no toxic and side effects, and can effectively treat various dizziness and relieve pain of patients.

3. Chinese patent: traditional Chinese medicine for treating vertigo; application number: 201210446779.0; application date: 2012-11-11; applicant: Guo Yihui; abstract: a traditional Chinese medicine for treating vertigo, characterized in that it includes the following raw materials in weight ratio: Pinellia 15g; Due to the adoption of the above technical solution, the present invention has the following advantages: it is a Chinese herbal medicine with special effects for treating vertigo, not only can stop vomiting and stop dizziness, but also can regulate and restore the whole nervous system, with low cost and few side effects.

Contents of the invention

The purpose of the present invention is to provide a preparation method of a traditional Chinese medicine preparation and its application in the treatment of vertigo. The Chinese medicine preparation can effectively treat the vertigo caused by various diseases. The phenomenon of neurological dysfunction in patients can also synergistically prevent the occurrence of other major diseases such as cardiovascular disease, cerebrovascular disease, and stroke. effect.

The present invention is realized through the following technical solutions:

The traditional Chinese medicine preparation for treating vertigo is made of the following raw materials in parts by weight: 25-35 parts of Radix Aconiti, 10-20 parts of Dried Ginger, 10-20 parts of Morinda officinalis, 10-20 parts of Guizhi, and 10 parts of Pinellia fragrans. ～20 parts, 10～20 parts of Shichangpu, 10～20 parts of Panax notoginseng, 10～20 parts of Epimedium, 10～20 parts of raw sun-dried ginseng, 3～9 parts of rhubarb; the preparation method comprises the following steps:

(1) Weigh Panax notoginseng and raw sun-dried ginseng according to the weight ratio, crush them to 4-24 mesh, add ethanol with a volume fraction of 60-80%, and carry out reflux extraction for 2-3 times, each time for 1-2 hours, to obtain Alcohol extract and alcohol extract dregs, ethanol is recovered after filtering the alcohol extract to obtain concentrated solution A;

(2) Weigh Aconite, Dried Ginger, Morinda officinalis, Guizhi, Pinellia, Shichangpu, Epimedium and Rhubarb according to the weight ratio, chop them up, and add the alcohol extraction obtained in step (1) in proportion Slag, extract 1 to 3 times, add water 10 to 15 times the dry weight of all medicinal materials each time, boil for 1 to 3 hours, collect volatile oil while extracting, combine water extracts, filter, and concentrate to obtain concentrated solution B;

(3) Mix concentrated solution A and concentrated solution B, add appropriate amount of traditional Chinese medicine excipients to make the required pharmaceutical dosage form.

Specifically, the prepared aconite is made from Heishun slices by salting, rinsing, boiling and frying.

The rhubarb is cooked rhubarb made from palmate rhubarb, tangut rhubarb or medicinal rhubarb through steaming. The preparation method includes the following steps: take raw rhubarb and cut it into small pieces, mix well with rice wine, mix raw rhubarb and rice wine The weight ratio is 1:0.3~0.5, put it in a steamer and steam it for 1~3 times, take it out and dry it in the sun to get cooked rhubarb.

The application of the above-mentioned traditional Chinese medicine preparations in the preparation of medicines for treating vertigo includes medicines prepared in the following dosage forms: oral liquids, pills or decoctions.

The preparation method of the oral liquid is as follows: mixing the concentrated liquid A and the concentrated liquid B, adding syrup to adjust the taste, the syrup is made of white sugar and honey according to the ratio of 0.1 to 0.3, sterilized and packaged to obtain.

The preparation method of the pill is as follows: mix the concentrated solution A and the concentrated solution B, concentrate in a vacuum, add the volatile oil obtained in step (2), add honey, starch paste, xanthan gum and mix evenly to make a water content of not more than 12%. of pills.

The preparation method of the decoction is as follows: mixing the concentrated solution A and the concentrated solution B, and concentrating to a relative density of 1.35-1.40; Within the range of 1.38-1.42, when cooled to 60-80°C, add the volatile oil obtained in step (2), add a mouthfeel regulator to adjust the mouthfeel, stir well, vacuum pump to eliminate air bubbles, and pack to get ready.

The nature of vertigo is mostly due to deficiency, such as deficiency of liver and kidney yin, internal movement of liver wind, deficiency of qi and blood, loss of nourishment of clear orifices, deficiency of kidney essence, and insufficiency of the brain; , phlegm, fire and qi are reversed, the upper offense clears the orifices, blood stasis stops, and numbness blocks the clear orifices. The traditional Chinese medicine preparation for the treatment of vertigo according to the present invention, its treatment principle mainly is to invigorate deficiency and relieve excess, and adjust yin and yang. Deficiency syndromes are mostly kidney essence deficiency and qi and blood decline. Those with essence deficiency replenish essence and produce marrow, nourishing liver and kidney; those with qi and blood deficiency nourish qi and blood, regulate spleen and kidney; Phlegm and blood stasis are the main treatments.

Carry out pharmacological analysis to the Chinese medicinal material that the present invention adopts as follows:

Preparation of aconitum: the processed product of the subroot of Ranunculaceae plant Aconitum carmichaeli Debx. Pungent, sweet, great heat; Guixin, Kidney, Spleen Meridians. Restore yang to rescue adverse events, tonify fire and support yang, and drive away wind, cold and damp pathogens. For yang deficiency and prostration, cold extremities with weak pulse, impotence, cold uterus, cold pain in trusted subordinates, vomiting and diarrhea due to deficiency-cold, edema due to yin-cold, exogenous pathogenesis caused by yang-deficiency, and arthralgia due to cold-dampness. Aconite contains mesaconitine, aconitine, hypaconitine, isoaconitine, talatisamine, chuanconitine A, B (chuan- wubaseA, B) and other active ingredients. Among them, Aconitum contains diester diterpene alkaloids, such as aconitine and mesoaconitine, which can be hydrolyzed into less toxic monoester alkaloids.

Aconitum is a plant of Ranunculaceae, the mother root is called Aconitum, which is used as an antispasmodic, cures wind, and rheumatic neuralgia; the lateral root (child root) is used as medicine, called aconite. Aconitum is an important medicine for dispelling cold and relieving pain. It can dispel the cold in the meridians and collaterals, and dispel the cold in the viscera. Treatment of profuse sweating and death of yang, Jueni of the limbs, cholera tendons, cold pain in the waist and knees due to weak kidney yang, love of cold in the body, lack of energy, wind-cold damp pain, beriberi and other diseases. Long-fried aconitum or newly adopted high-pressure steaming can reduce toxicity. Aconitum is used in combination with other medicines, such as dried ginger, which have complementary effects to strengthen its power of warming yang, expelling cold and relieving pain.

Dried ginger: the dried rhizome of Zingiber oj-jicinale Rosc. Another name: white ginger, average ginger, dried ginger. Spicy in the mouth, hot in nature. Return spleen, stomach, kidney, heart, lung channel. Warming the middle and dispelling the cold, returning the yang to unblock the veins, warming the lungs and transforming the drink. It is commonly used for cold pain in the abdomen, vomiting and diarrhea, cold extremities and weak pulse, cold drink and wheezing and coughing. Ginger contains active ingredients such as gingerol, zingerone, and gingerol, which have multiple health functions such as dispelling cold, dampness, warming the stomach, and accelerating blood circulation. Gingerol has a stimulating effect on the oral cavity and gastric mucosa, can promote the secretion of digestive juice, increase appetite, and increase intestinal tension, rhythm and peristalsis; gingerolone has an exciting effect on the respiratory and vasomotor centers, can promote blood circulation, Stomach, refreshing, refreshing.

Studies have shown that ginger dry powder is 90% effective in treating headaches, dizziness, nausea, vomiting and other symptoms of motion sickness, and the efficacy can last for more than 4 hours. Folks use ginger to prevent motion sickness and seasickness, or paste Neiguan acupoint, which has obvious effects, so it has the reputation of "the holy medicine for vomiting". Modern pharmacological studies have shown that methanol or ether extracts of dried ginger have sedative, analgesic, anti-inflammatory, anti-nausea and transiently elevated blood pressure; water extracts or volatile oils can significantly prolong the time of thrombus formation; alcohol extracts and their Containing gingerol and gingerol, it has significant molluscicide and anti-schistosome effects.

Morinda officinalis: Latin scientific name Morinda officinalis How., is the dried root of Morinda officinalis How. Sweet, pungent, slightly warm in nature. Return kidney, Liver Channel. It has the effects of invigorating kidney yang, strengthening muscles and bones, and expelling rheumatism. It is often used for impotence and nocturnal emission, cold uterine infertility, irregular menstruation, cold and pain in the lower abdomen, rheumatic arthralgia, and flaccidity of muscles and bones.

Guizhi: The Latin scientific name is CassiaTwig, which is the dry twig of Cinnamomum cassia Presl, a plant of Lauraceae, with a specific aroma. Its nature and flavor are pungent, sweet, and warm, and it enters the lung, heart, and bladder meridian. It is a commonly used warming medicine for treating interior cold. Compatibility of medicines can treat deficiency of kidney yang, decline of vital energy, cold limbs and weak pulse. Compatibility with other warming medicines can treat abdominal cold pain, cold arthralgia and low back pain. It has obvious analgesic and anti-cancer effects.

French pinellia: Latin scientific name Rhizoma Pinelliae, is the tuber of Pinellia ternata (Thunb) Breit. Pungent, warm; Return spleen, stomach, lung meridians. Functions and indications: drying dampness and resolving phlegm; used for coughing and dyspnea due to excess phlegm, dizziness and palpitation due to phlegm retention, dizziness due to wind-phlegm, and headache due to syncope due to phlegm. Pinellia can activate the efferent activity of the vagus nerve and has an antiemetic effect. It can also inhibit the activity of pepsin, protect the gastric mucosa, and promote the repair of the gastric mucosa. It has anti-pyloric ulcer, indomethacin ulcer and stress ulcer in rats. role.

Calamus calamus: Latin scientific name: Acorus tatarinowii, belongs to Araceae, calamus is a grass-like perennial herb, and its rhizome is often used for medicinal purposes. Functions and indications: reducing dampness and appetizing, resuscitating and eliminating phlegm, refreshing mind and improving intelligence. It is used for abdominal distension without hunger, dysentery, stupor and epilepsy, forgetfulness and deafness. Regulating qi, promoting blood circulation, dispersing wind, removing dampness. Treatment of epilepsy, syncope due to phlegm, febrile coma, forgetfulness, air-occlusion deafness, and chest distress. Acorus calamus contains a variety of volatile oils, the main components of which are β-asarone, cis-methyl isoeugenol, elemene, asaraldehyde, δ-piperene, thymol and myroxylic acid, etc. . Studies have shown that asarone in the volatile oil is an active ingredient for sedation, and the decoction made from the water extract of the rhizome of Acorus calamus is clinically used to treat epilepsy and other nervous system disorders, and has a good curative effect. Some nervous system animal models have significant physiological activity. Oral administration of Shichangpu decoction can promote the secretion of digestive juice, prevent abnormal gastrointestinal fermentation, and relieve intestinal smooth muscle spasm.

Panax notoginseng: It is the dry root and rhizome of Panax notoginseng (Burk.) F.H.Chen of the Araliaceae plant. Sweet, slightly bitter, warm. Return liver, stomach warp. Dispersing blood stasis to stop bleeding, reducing swelling and relieving pain. For hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic bleeding, chest and abdomen tingling pain, tumbling and swelling pain.

Epimedium: Scientific name: Epimedium brevicornu Maxim., Epimedium brevicornu Maxim., Epimedium brevicornu Maxim., Epimedium pungent and sweet, warm in nature, go through the liver and kidney meridians, and is an important medicine for nourishing the gate of life, benefiting essence, strengthening muscles and bones, tonifying kidney and strengthening yang. Indications for impotence and premature ejaculation, backache and leg pain, numbness of limbs, hemiplegia, neurasthenia, forgetfulness, tinnitus, dizziness and other diseases. Pharmacological experimental studies have shown that Epimedium can increase blood flow in cardiovascular and cerebrovascular, promote hematopoietic function, immune function and bone metabolism, and has anti-aging and anti-tumor effects.

Modern research shows that Epimedium contains ingredients such as icariin, volatile oil, wax alcohol, phytosterol, tannin, and vitamin E. It can excite sexual function and promote semen secretion in animals. There are also antihypertensive (causing peripheral vasodilation), hypoglycemic, diuretic, antitussive and expectorant, and vitamin E-like effects. Pharmacological experimental studies have shown that Epimedium can increase blood flow in cardiovascular and cerebrovascular, promote hematopoietic function, immune function and bone metabolism, and has anti-aging and anti-tumor effects.

Raw sun-dried ginseng: It is made by digging out Panax ginseng C. A. Mey together with fibrous roots, removing the soil and drying in the sun. Sweet, slightly bitter, warm and flat. Return spleen, lung meridian, heart meridian. Invigorating qi, solidifying, promoting body fluid, calming the nerves, and improving intelligence. The fleshy root of ginseng is a well-known strong tonic. It is suitable for adjusting blood pressure, restoring heart function, neurasthenia and physical weakness. It also has the effects of eliminating phlegm, strengthening the stomach, diuresis and excitement.

Rhubarb: It is the dry root and rhizome of Rheum palmatum L., Rheum tanguticumMaxim.ex Balf. or medicinal Rheum officinale Baill. of Polygonaceae. The stems and leaves wither in late autumn or excavated before germination in the next spring, remove fine roots, scrape off the outer skin, cut petals or segments, and string them into strings to dry or directly dry. It has the effects of attacking stagnation, clearing damp and heat, purging fire, cooling blood, removing blood stasis, and detoxifying.

The beneficial effects of the present invention are:

1, the Chinese medicine preparation for the treatment of vertigo according to the present invention adopts pure natural Chinese herbal medicine as raw material, and its formula combination is drafted by Guangxi University of Traditional Chinese Medicine through clinical trials, and each raw material wherein can play the effect of treating vertigo synergistically , has a very good curative effect on the treatment of vertigo caused by various diseases. While eliminating the symptoms of vertigo, it can comprehensively regulate the liver, kidney, heart, spleen and lungs of the human body, and prevent the occurrence of various major diseases from the inside of the body.

2. This traditional Chinese medicine preparation can effectively treat vertigo caused by various diseases. Its treatment method is mainly based on internal adjustment, which can fundamentally improve the patient's neurological disorders, improve blood circulation, and can also synergistically prevent cardiovascular diseases, cerebrovascular diseases, and so on. Disease, stroke and other major diseases, it has the functions of nourishing the liver and kidney, reducing dampness and appetizing, refreshing the mind, replenishing essence, strengthening bones and muscles, clearing away heat and eliminating phlegm, and regulating immune function.

3. The Chinese medicinal preparation for the treatment of vertigo according to the present invention has simple preparation process, wide sources of raw materials, and standardized drug use. The Chinese medicinal materials used are all recorded in the Pharmacopoeia of the People's Republic of China. The Chinese medicinal preparation is convenient to take and is suitable for the masses. Wide range, wide pertinence, can treat dizziness caused by various diseases, and has no toxic and side effects on human body when used within the prescribed consumption range.

Detailed ways

In order to introduce the present invention in more detail, the present invention will be further described below in conjunction with the embodiments.

Example 1

The traditional Chinese medicine preparation for the treatment of vertigo in the present embodiment is made of the following raw materials in parts by weight: 30 parts of Radix Aconiti, 15 parts of Dried Ginger, 15 parts of Morinda officinalis, 14 parts of Guizhi, 14 parts of Pinellia, 16 parts of calamus, 13 parts of notoginseng, 15 parts of epimedium, 13 parts of raw sun-dried ginseng, and 6 parts of rhubarb.

Its preparation method comprises the following steps:

(1) Weigh Panax notoginseng and raw sun-dried ginseng according to the weight ratio, crush them until they can pass through a 4-mesh standard sieve, add ethanol with a volume fraction of 70%, and carry out reflux extraction twice, each time for 1.5 hours, to obtain the alcohol extract and Alcohol extraction of medicinal residues, recovery of ethanol after filtering the alcohol extraction solution to obtain concentrated solution A;

(2) Weigh Aconite, Dried Ginger, Morinda officinalis, Guizhi, Pinellia, Shichangpu, Epimedium and Rhubarb according to the weight ratio, chop them up, and add the alcohol extraction obtained in step (1) in proportion Slag, extract 3 times, add water 15 times of its total weight for the first time, boil for 2 hours, add water 12 times of its total weight for the last two times, boil for 1.5 hours each time, collect volatile oil while extracting, and combine water extracts Filter and concentrate to obtain concentrate B;

(3) The oral liquid is made according to the relevant preparation process of the medicine. The preparation method includes: mixing the concentrated liquid A and the concentrated liquid B, adding volatile oil, adding syrup with a water content of 40% to adjust the taste, and the syrup is composed of white sugar and The honey is made according to the ratio of 1:0.1, so that it contains the prescribed content of traditional Chinese medicine ingredients, sterilized and packaged, and then it can be obtained.

Specifically, the prepared aconite is made from Heishun slices by salting, rinsing, boiling and frying.

The rhubarb is cooked rhubarb made from palmate rhubarb, tangut rhubarb or medicinal rhubarb through steaming. The preparation method includes the following steps: take raw rhubarb and cut it into small pieces, mix well with rice wine, mix raw rhubarb and rice wine The weight ratio is 1:0.4, put it in a steamer and steam it twice, take it out and dry it in the sun to get cooked rhubarb.

Example 2

A traditional Chinese medicine preparation for treating vertigo, made of the following raw materials in parts by weight: 30 parts of Radix Aconiti, 16 parts of Dried Ginger, 14 parts of Morinda officinalis, 15 parts of Guizhi, 15 parts of Pinellia chinensis, and 17 parts of Shichangpu , 15 parts of Panax notoginseng, 15 parts of Epimedium, 17 parts of raw sun-dried ginseng, and 6 parts of rhubarb.

Its preparation method comprises the following steps:

(1) Weigh Panax notoginseng and raw sun-dried ginseng according to the weight ratio, crush them until they can pass through a 10-mesh standard sieve, add ethanol with a volume fraction of 75%, and carry out reflux extraction twice, each time for 2 hours, to obtain the alcohol extract and Alcohol extraction of medicinal residues, recovery of ethanol after filtering the alcohol extraction solution to obtain concentrated solution A;

(2) Weigh Aconite, Dried Ginger, Morinda officinalis, Guizhi, Pinellia, Shichangpu, Epimedium and Rhubarb according to the weight ratio, grind them to 60 mesh, and add the alcohol obtained in step (1) in proportion Extract the dregs, extract twice, add water 15 times its total weight for the first time, boil for 2 hours, add water 12 times its total weight for the second time, boil for 2 hours, collect volatile oil while extracting, and combine water extracts Filter and concentrate to obtain concentrate B;

(3) Make pills according to the relevant preparation process of medicines. The preparation method includes: mixing concentrated solution A and concentrated solution B, concentrating in vacuum, adding volatile oil, adding honey, starch paste, xanthan gum and mixing evenly to make the water content It is a 10% pill.

Specifically, the prepared aconite is made from Heishun slices by salting, rinsing, boiling and frying.

The rhubarb is cooked rhubarb made from palmate rhubarb, tangut rhubarb or medicinal rhubarb through steaming. The preparation method includes the following steps: take raw rhubarb and cut it into small pieces, mix well with rice wine, mix raw rhubarb and rice wine The weight ratio is 1:0.4, put it in a steamer and steam it twice, take it out and dry it in the sun to get cooked rhubarb.

Example 3

A traditional Chinese medicine preparation for treating vertigo, made of the following raw materials in parts by weight: 30 parts of Radix Aconiti, 18 parts of Dried Ginger, 14 parts of Morinda officinalis, 16 parts of Guizhi, 15 parts of Pinellia chinensis, and 15 parts of Shichangpu , 15 parts of Panax notoginseng, 14 parts of Epimedium, 13 parts of raw sun-dried ginseng, and 5 parts of rhubarb.

Its preparation method comprises the following steps:

(1) Weigh Panax notoginseng and raw sun-dried ginseng according to the weight ratio, crush them until they can pass through a 20-mesh standard sieve, add ethanol with a volume fraction of 70%, and carry out reflux extraction for 3 times, each time for 1 hour, to obtain the alcohol extract and Alcohol extraction of medicinal residues, recovery of ethanol after filtering the alcohol extraction solution to obtain concentrated solution A;

(2) Weigh Aconite, Dried Ginger, Morinda officinalis, Guizhi, Pinellia, Shichangpu, Epimedium and Rhubarb according to the weight ratio, chop them up, and add the alcohol extraction obtained in step (1) in proportion Slag, extract 3 times, add water 15 times its total weight for the first time, boil for 2 hours, then add water 10 times its total weight twice, boil for 1.5 hours each time, collect volatile oil while extracting, and combine water extracts Filter and concentrate to obtain concentrate B;

(3) Make a decoction according to the relevant preparation process of the drug. The preparation method includes: mixing the concentrated solution A and the concentrated solution B, concentrating to a relative density of 1.38; adding refining syrup to make up the volume, heating and refining for 2 hours, and controlling the moisture Dissipate so that the relative density is within the range of 1.40, and when cooled to 70°C, pulverize until it can pass through a 4-mesh standard sieve, add a mouthfeel regulator to adjust the mouthfeel, stir fully, vacuum pump to eliminate air bubbles, and pack it separately.

Specifically, the prepared aconite is made from Heishun slices by salting, rinsing, boiling and frying.

The rhubarb is cooked rhubarb made from palmate rhubarb, tangut rhubarb or medicinal rhubarb through steaming. The preparation method includes the following steps: take raw rhubarb and cut it into small pieces, mix well with rice wine, mix raw rhubarb and rice wine The weight ratio is 1:0.5, steamed in a steamer for 3 times, taken out and dried in the sun to obtain cooked rhubarb.

The traditional Chinese medicine preparation prepared according to the method of the present invention is used in clinical trials to find that the therapeutic effect is remarkable, and the following is a typical case. The following cases are used to illustrate the effect of this patent for the treatment of vertigo, and are not limited to the diseases in the examples.

(1) Treatment of cervical vertigo. Choose 32 routine clinical patients with vertigo suffering from carotid arteriosclerosis, take the oral liquid that embodiment 1 makes, totally 14 days. The results showed that 27 cases were effective (the effective rate was 84.37%), and the peak systolic blood flow velocity, average blood flow velocity and end-diastolic blood flow velocity of the cervical vertebral artery were higher than those before treatment; the whole blood viscosity, plasma specific viscosity , hematocrit, erythrocyte aggregation index and fibrinogen content were all lower than before treatment; his vertigo symptoms disappeared and he could live a normal life.

(2) The treatment of motion sickness. Choose 12 routine adults who have had motion sickness every time by car, 4 males, 8 females, aged 25-50 years old, took the pills made in Example 2, totally 10 days. Within six months after taking the medicine, he took a car at any time and at will for a total of 36 times. The results showed that the frequency of dizziness, headache, nausea and vomiting, or fatigue and drowsiness was 4 times. It has been shown to have a good effect on the treatment of motion sickness.

(3) Treatment of cerebral vertigo. Select 52 cases of vertigo patients with cerebral atherosclerosis, 30 cases of males, 22 cases of females, aged 60-75 years, were randomly divided into control group and drug-adding group, 26 cases in each group, 15 males and 11 females, and the course of treatment was 14 days. sky. The control group was given conventional treatment, and the drug-adding group was given the decoction prepared in Example 3 in addition to the same conventional treatment as the control group. In the conventional group, 13 cases of vertigo symptoms disappeared (50%), and 6 cases of vertigo symptoms relieved (23.07%), with a total effective rate of 73.07%; %), the total effective rate was 84.61%. The therapeutic effect of the drug-adding group was significantly better than that of the routine group.

Claims (7)

1. A traditional Chinese medicine preparation, characterized in that it is made from the following raw materials in parts by weight: 25 to 35 parts of aconite, 10 to 20 parts of dried ginger, 10 to 20 parts of Morinda officinalis, 10 to 20 parts of cassia twig, 10-20 parts of French Pinellia, 10-20 parts of Shichangpu, 10-20 parts of Panax notoginseng, 10-20 parts of Epimedium, 10-20 parts of raw sun-dried ginseng, 3-9 parts of rhubarb; the preparation method includes the following steps : (1) Weigh Panax notoginseng and raw sun-dried ginseng according to the weight ratio, crush them to 4-24 mesh, add ethanol with a volume fraction of 60-80%, and carry out reflux extraction for 2-3 times, each time for 1-2 hours, to obtain Alcohol extract and alcohol extract dregs, ethanol is recovered after filtering the alcohol extract to obtain concentrated solution A; (2) Weigh Aconite, Dried Ginger, Morinda officinalis, Guizhi, Pinellia, Shichangpu, Epimedium and Rhubarb according to the weight ratio, chop them up, and add the alcohol extraction obtained in step (1) in proportion Slag, extract 1 to 3 times, add water 10 to 15 times the dry weight of all medicinal materials each time, boil for 1 to 3 hours, collect volatile oil while extracting, combine water extracts, filter, and concentrate to obtain concentrated solution B; (3) Mix concentrated solution A and concentrated solution B, add appropriate amount of traditional Chinese medicine excipients to make the required pharmaceutical dosage form. 2. The traditional Chinese medicine preparation according to claim 1, characterized in that, said Radix Aconiti is prepared by salting, bleaching, boiling and frying of Heishun slices. 3. The traditional Chinese medicine preparation according to claim 1, wherein said rhubarb is cooked rhubarb made from rhubarb palmatum, rhubarb tangutata or medicinal rhubarb through cooking, and the preparation method comprises the following steps: taking raw rhubarb Cut rhubarb into small pieces, mix well with rice wine, the weight ratio of raw rhubarb to rice wine is 1:0.3-0.5, steam in a steamer for 1-3 times, take out and dry in the sun to get cooked rhubarb. 4. The application of the traditional Chinese medicine preparation as claimed in claim 1 in the preparation of medicine for the treatment of vertigo, characterized in that it comprises medicine prepared into the following dosage forms: oral liquid, pill or decoction. 5. the Chinese medicine preparation according to claim 4 is in the application of preparation treatment vertigo medicine, it is characterized in that, the preparation method of described oral liquid is: concentrate A and concentrate B are mixed, add volatile oil, add syrup fixed To contain and adjust the taste, the syrup is made of white sugar and honey at a ratio of 0.1 to 0.3, sterilized and packaged to obtain. 6. The application of the traditional Chinese medicine preparation according to claim 4 in the preparation of drugs for the treatment of vertigo, characterized in that the preparation method of the pill is: mixing the concentrated solution A and the concentrated solution B, concentrating in a vacuum, and adding step (2) The obtained volatile oil is mixed with honey, starch paste and xanthan gum evenly to make a pill-shaped medicine with a moisture content of not more than 12%. 7. The application of the traditional Chinese medicine preparation according to claim 4 in the preparation of drugs for the treatment of vertigo, characterized in that the preparation method of the decoction is: mixing the concentrated solution A and the concentrated solution B, concentrating to a relative density of 1.35-1.40 ; add refining syrup to constant volume, heat and refine for 1-2 hours, control water loss, make the relative density in the range of 1.38-1.42, add the volatile oil obtained in step (2) when cooling to 60-80°C, and then add the taste adjustment Prepare the taste with the agent, fully stir, vacuum pump to eliminate air bubbles, pack separately, and get ready.