CN108339101A - The preparation of the five internal organs function of warming yang and gore removing soft extract and the method for improving mouthfeel - Google Patents

The preparation of the five internal organs function of warming yang and gore removing soft extract and the method for improving mouthfeel Download PDF

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CN108339101A
CN108339101A CN201810237925.6A CN201810237925A CN108339101A CN 108339101 A CN108339101 A CN 108339101A CN 201810237925 A CN201810237925 A CN 201810237925A CN 108339101 A CN108339101 A CN 108339101A
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parts
soft extract
extract
added
internal organs
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李学坚
唐农
吴林
蒋凌风
银江林
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Guangxi University of Chinese Medicine
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Guangxi University of Chinese Medicine
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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Abstract

The invention discloses the preparations of the five internal organs function of warming yang and gore removing soft extract and the method for improvement mouthfeel, the soft extract to be made of following raw material：Radix aconiti lateralis preparata, rhizoma zingiberis, Morinda officinalis, cassia twig, rhizoma pinellinae praeparata, grass-leaved sweetflag, Radix Notoginseng, Herba Epimedii, sun-dried ginseng and rheum officinale；Preparation method includes（1）Alcohol extracting（2）Water carries（3）Concentration（4）Refine syrup（5）Prepare finished product.The decoction of script is prepared into soft extract by method of the present invention, is overcome decoction and is unfavorable for quantitatively taking, and the problems such as inconvenient, dose is big, bitter is preserved；Made soft extract taste is good, without gastric disorder causing nausea sense of discomfort when taking, masks its bitter taste and pungent significantly, up-to-standard, can meet the convenience of long-term treatment, improves its whole curative effect.The soft extract has effects that temperature helps Yuanyang, Eradicates blood stasis and smoothing collaterals, dissipating phlegm for resuscitation, is mainly used for treating vascular dementia and vertigo, improves immunity, it may also be used for the pre- diseases such as anti-stroke.

Description

The preparation of the five internal organs function of warming yang and gore removing soft extract and the method for improving mouthfeel
Technical field
The present invention relates to the field of Chinese medicines, the specifically method of the preparation of the five internal organs function of warming yang and gore removing soft extract and improvement mouthfeel.
Background technology
Decoction is that medicinal material adds water to cook after a certain period of time, removes slag and takes juice that liquid dosage form is made, mainly for for oral administration, a small number of external applications Be used as bathing, it is stifling, containing gargling.It is that China applies a kind of earliest, widest dosage form, has been played in disease preventing and treating very big Effect is still one of the important dosage form of tcm clinical practice application at present, according to incompletely statistics, in traditional chinese medical science clinic prescription about using decoction Account for 50% or so.
Decoction is simple and practicable with preparing, and the advantages that absorbing soon, can play drug effect rapidly, but there is also many deficiencies Place, such as：Decoction volume is larger, bitter, storage and inconvenient to carry；It is according to doctor formula Extemporaneous application, no mostly It is preferably a large amount of to prepare, also it is unfavorable for rescuing urgent patient in time；It is difficult to store long, easily mouldy, fermentation causes to go bad.Therefore, in recent years Effective form improvement, such as herb mixture, granule, oral solution etc. are carried out to decoction to be all to try to retain decoction advantage gram Take the TCM modern preparations to grow up on the basis of its disadvantage.Soft extract is also known as oral pastes, cream is grown, and is that medicinal material adds water to cook, Remove slag, concentrate after stiff semifluid shape made of sugaring or refined honey leach preparation.The dosage form uses, takes for a long time, changes for convenience Kind mouthfeel improves curative effect and formulates.The Jiangnan doctor Qin of the Republic of China uncle does not say：Herbal paste person, learned moist, lid decocts concoction into fat liquid And so the uninteresting valetudinarian, invalid of the nutrition vital organs of the human body, therefore custom is also known as cream wetting drug.
The five internal organs function of warming yang and gore removing soup is one of the important prescription of Chinese medicine Fu Yang schools, certainly for Guangxi University of Chinese Medicine professor Tang Nong Quasi- clinical experience side, through Clinical practice closely for many years, it was demonstrated that it helps Yuanyang, Eradicates blood stasis and smoothing collaterals, dissipating phlegm for resuscitation and other effects with temperature. Since decoction uses and preserves inconvenience, it is therefore necessary to form improvement is carried out to it, so that it is used more convenient, be conducive into One step expands its use scope.
At present also about the preparation method of soft extract in open source literature, but it is much do not focus on improvement mouthfeel, carry High curative effect, such as：
1, Chinese patent：A kind of compound roxburgh anoectochilus terminal bud soft extract and preparation method thereof；Application number：201610217015.2；The applying date： 2016-04-08；Applicant：Fujian Jincao Biological Group Co., Ltd.；Abstract：The invention discloses a kind of compound gold threads Lotus soft extract and preparation method thereof.Step is by roxburgh anoectochilus terminal bud, the loguat leaf except floss removing, perilla leaf, dried orange peel, semen armeniacae amarae, peppermint Leaf is respectively crushed into coarse powder, and Radix Glycyrrhizae and Siraitia grosvenorii are cleaned, and moisturizing rear Radix Glycyrrhizae with water is sliced, Siraitia grosvenorii stripping and slicing；Take roxburgh anoectochilus terminal bud, purple perilla Leaf, dried orange peel, dried peppermint leaf, semen armeniacae amarae five tastes coarse powder are uniformly mixed, steam distillation, and water is collected when distillate clarification is without oil droplet Steam distillation liquid, and obtain the dregs of a decoction；The coarse powder of the dregs of a decoction and loguat leaf, licorice tablet and arhat fruit block are added water to cook 2-3 times, Each 1h, collecting decoction filter while hot, and filtrate decompression is concentrated to give concentrate；Maltose is heated, the concentrate is added Natural cooling afterwards, adds the steam distillation liquid and adds water to 1000ml and stir evenly；Can also there are packing and sterilizing Step.Gained compound roxburgh anoectochilus terminal bud soft extract, which has, alleviates cough with lung heat, smooth throat to stop cough, symptom of having sore throat effect.
2, Chinese patent：A kind of Chinese medicine soft extract and preparation method thereof for treating hectic fever due to yin；Application number： 201510759315.9；The applying date：2015-11-10；Applicant：Xia Fangjun；Abstract：The present invention discloses a kind of hectic fever due to yin for the treatment of Chinese medicine soft extract and preparation method thereof includes the raw material of following parts by weight proportioning：16-18 parts of Fermented Soybean, piaszky grape juice 10- 12 parts, 8-10 parts of Oliva mustelina lamarck, 15-17 parts of moutan bark, 10-12 parts of otter meat, 6-8 parts of barberry, snow 15-17 parts of tea, bark of ash 5-7 Part, 12-14 parts of radix cynanchi atrati, 18-20 parts of Colla Plastri Testudinis, 9-11 parts of rhizoma pancis majoris leaf, 13-15 parts of hairy wormwood herb, 10-12 parts of bamboo juice, rock sugar 4-6 20-22 parts of part and honey, the Chinese medicine soft extract good effect of the treatment hectic fever due to yin, quick, treatment cycle is short.
3, Chinese patent：A kind of soft extract and preparation method thereof for treating coronary heart disease；Application number：201510107360.6； The applying date：2015-03-07；Applicant：Li Chuanwei；Abstract：The invention discloses a kind of soft extracts and its system for treating coronary heart disease Preparation Method.Its prescription is as follows：Radix Codonopsis 150-250g, Radix Astragali 100-200g, dried human placenta 80-120g, jujube 60-80, honey-fried licorice root 50-70g, Rhizoma Chuanxiong 50-70g, Rhizoma Gastrodiae 80-120g, pueraria lobata 100-140g, safflower 80-120g, Chinese yam 80-120g, Radix Angelicae Sinensis 100- 140g, prepared fleece flower root 100-140g, stir-baked CORTEX EUCOMMIAE 80-120g, Radix Salviae Miltiorrhizae 100-140g, wilsonii 80-120g, Cortex Phellodendri 80-120g, Fu Siberian cocklebur 100-140g, Radix Curcumae 80-100g, matrimony vine 100-200g, Schisandra chinensis 15-35g, each 80-120g of red Radix Paeoniae Alba, black fungus 50- 70g, wine steam fruit of glossy privet 100-140g, earthworm 100-140g.By above-mentioned Chinese medicine decocting and concentrating, add sugar refinery and molten donkey-hide gelatin 80- 120g, ginseng pulverate 40-60g, Radix Notoginseng powder 40-60g, pilose antler powder 120-180g are added refined honey and allow the food antiseptic of addition Agent.Then it stirs evenly, stand, filtering, filling as finished product.For treating the heart diseases such as coronary heart disease.
Invention content
The object of the present invention is to provide the preparation of the five internal organs function of warming yang and gore removing soft extract and the method for improvement mouthfeel, the five internal organs Wen Yang Stagnation resolvation soft extract was decoction originally in clinical application, had effects that temperature helps Yuanyang, Eradicates blood stasis and smoothing collaterals, dissipating phlegm for resuscitation, Major Clinical to use In treatment vascular dementia, treatment vertigo, immunity is improved, it can also the pre- diseases such as anti-stroke.It is incited somebody to action the present invention provides a kind of The method that decoction is prepared into soft extract and is obviously improved its mouthfeel, to expand its application range, overcome decoction volume it is larger, Bitter, storage and it is inconvenient to carry the deficiencies of place.
The invention is realized by the following technical scheme：
The preparation of the five internal organs function of warming yang and gore removing soft extract and the method for improving mouthfeel, the five internal organs function of warming yang and gore removing soft extract is by following heavy The raw material of amount number is made：25~35 parts of radix aconiti lateralis preparata, 10~20 parts of rhizoma zingiberis, 10~20 parts of Morinda officinalis, 10~20 parts of cassia twig, method half 10~20 parts of summer, 10~20 parts of grass-leaved sweetflag, 10~20 parts of Radix Notoginseng, 10~20 parts of Herba Epimedii, 10~20 parts of sun-dried ginseng, rheum officinale 3~9 Part；Preparation method includes the following steps：
（1）Alcohol extracting：Radix Notoginseng and sun-dried ginseng are weighed by weight ratio, is crushed to 5~20 mesh, and it is 60~80% that volume fraction, which is added, Ethyl alcohol, carries out refluxing extraction 2~3 times, 1~2 hour every time, obtains alcohol extract and the alcohol extracting dregs of a decoction, second is recycled after alcohol extract filtering Alcohol obtains alcohol extracting dilute cream；
（2）Water carries：Radix aconiti lateralis preparata, rhizoma zingiberis, Morinda officinalis, cassia twig, rhizoma pinellinae praeparata, grass-leaved sweetflag, Herba Epimedii and rheum officinale are weighed by weight ratio, Chopping, with step（1）The alcohol extracting dregs of a decoction of gained merge, and extract 1~3 time, 10~15 times of all medicinal material dry weights are added every time Water boils 1~3 hour, and extraction while collects volatile oil, merges Aqueous extracts, filters, and concentration obtains water and puies forward dilute cream；
（3）Concentration：By step（1）Alcohol extracting dilute cream and step（2）Water carry dilute cream mixing, be further concentrated into relative density 1.35~1.40, obtain clear cream；
（4）Refine syrup：It takes white granulated sugar appropriate, the water of its weight 40~60% is added, lemon is added in 10~20min of ebuillition of heated Acid and honey, infusion 3~5min on one side stir while, and control total sugar content is 55~70%；
（5）Prepare finished product：Aseptically, qinghuo reagent, with refining syrup constant volume, heating is tempered 1~2 hour, and moisture is controlled It scatters and disappears, makes relative density in 1.38~1.42 ranges, volatile oil is added when being cooled to 60~80 DEG C, adds mouth feel modifying agents Improve mouthfeel, be sufficiently stirred, vacuum suction eliminates bubble, dispenses to get the five internal organs function of warming yang and gore removing soft extract.
The preparation method of above-described the five internal organs function of warming yang and gore removing soft extract, the method for improving mouthfeel are added in soft extract Mouth feel modifying agents, the mouth feel modifying agents are combined by beta-cyclodextrin, Sucralose, vanillic aldehyde and are made, and wherein each component accounts for pan-fried The weight ratio of paste is respectively：β-cyclodextrin 5~15%, Sucralose 0.05~0.30%, vanillic aldehyde 0.2~2.0%.
It is as follows that Pharmacological Analysis is carried out to Chinese medicine of the present invention：
Radix aconiti lateralis preparata：The ranunculaceae plant rhizome of Chinese monkshood（Aconitum carmichaeli Debx.）Sub- root processed goods.It is pungent, sweet, greatly Heat；It belongs to the heart, kidney, spleen channel.Recuperating depleted yang, mends fire supporing yang, by wind-cold damp pathogen.It collapses for yang depletion, cold weak pulse of limb, impotence, Gong Leng, Trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, cold sensation of the genitalia oedema, deficiency of yang diseases caused by external factors, numbness and ache of cold dampness.Monkshood contains mesaconitine（mesaconitine）, crow Head alkali（aconitine）, Hypaconitine（hypaconitine）, isoaconitine（isoaconitine）, tower draw younger brother's amine （talatisamine）, chuan-wu base A, second（chuan-wubaseA、B）Isoreactivity ingredient.Monkshood diterpene containing diester-type therein Alkaloid, such as aconitine, mesaconitine can become the smaller monoesters Alkaloid of toxicity through hydrolysis.
The rhizome of Chinese monkshood is ranunculaceae plant, and female root is antispastic, smelting wind low, rheumatism neuralgia the rhizome of Chinese monkshood；Lateral root（Sub- root）Enter Medicine is monkshood.The rhizome of Chinese monkshood is eliminating cold to stop pain key medicine, and the channels and collaterals that can not only dispel are cold, but also can to dissipate internal organs cold；There is Hui Yang, by cold, wind-damp dispelling Effect.Control loss of YANG due to profuse perspiration, four limbs faint the weak waist and knee crymodynia of inverse, choleraic myospasm, kidney yang, shape it is cold like cold, lassitude and The diseases such as wind-cold-dampness ache, tinea pedis.The high pressure steaming that the rhizome of Chinese monkshood is decocted or used recently long, can reduce toxicity.The rhizome of Chinese monkshood makes with other medicine compatibilities With such as rhizoma zingiberis, there is complementary effect, to reinforce power of its Wen Yang by cold analgesic.
Rhizoma zingiberis：For the dry rhizome of zingiber Zingiber oj-jicinale Rosc..Also known as：Bai Jiang, equal ginger, Dry ginger.Acrid flavour, property heat.Returns spleen, stomach, kidney, the heart, lung channel.Warming spleen and stomach for dispelling cold, recover Yang and smooth venation, warming lung and resolving fluid.It is cold to be usually used in gastral cavity abdomen Bitterly, vomiting and diarrhea, cold weak pulse of limb, cold drink are breathed with cough.Jiang Hanyou gingerols, zingerone, gingerol isoreactivity ingredient have dispelling cold, dispel Wet, warm stomach accelerates the plurality of health care functions such as blood circulation.Gingerol has stimulation to oral cavity and gastric mucosa, can promote digestion Liquid is secreted, and is improved a poor appetite, and can make intestines tension, the rhythm and pace of moving things and wriggle to increase；Zingerone has excited work to breathing and vasomotor center With can promote blood circulation, stomach invigorating, refresh oneself, restoring consciouness.
There are some researches prove, ginger dry powder to the symptoms effective percentage such as the headache of motion sickness, dizziness, Nausea and vomiting up to 90%, and Sustainable 4 hours of drug effect or more.It is civil with ginger carsickness-proof, seasick, or patch nei guan point is eaten, have obvious effects on therefore and have The reputation of " panacea of vomitting ".Modern pharmacological studies have shown that the methanol or ether extract of rhizoma zingiberis have calm, analgesia, anti-inflammatory, preventing or arresting vomiting and short Temporarily increase the effect of blood pressure；Water extract or volatile oil can be obviously prolonged thrombosis time；Alcohol extracting thing and its contained ginger are peppery Element and the peppery ketenes of ginger have significantly go out spiral shell and anti-schistosome function.
Morinda officinalis：Classification system Morinda officinalis How. are madder wort Morinda officinalis Morinda ojj:The dry root of icinalis How, alias Morinda offcinalis How, Ba Jitian.It is sweet in flavor, pungent, slightly warm in nature.Return kidney, Liver Channel.With kidney-replenishing, The effect of strengthening the bones and muscles, wind-damp dispelling.It is usually used in being used for impotence and seminal emission, uterus cold infertile, irregular menstruation, few abdomen crymodynia, arthralgia pain due to rheumatism, muscle The atrophic debility of bones is soft.
Cassia twig：Classification system CassiaTwig is the drying of canella Chinese cassia tree Cinnamomum cassia Presl Spray has special fragrance.Its nature and flavor acrid, sweet, warm, enters lung, the heart, bladder warp, is to cure mainly the common drugs for dispelling internal cold of interior cold, has complement The effect of sun, promoting blood circulation, warming spleen and stomach, often with tonifying liver renal drug, fill blood medicine compatibility, treatment the insufficiency of the kidney yang, the Yang-function insufficiency of kidneyzang, the cold arteries and veins of limb It is micro-, with other drugs for dispelling internal cold compatibilities treatment coldness and pain in the epigastrium, arthritis pain in the back, have the function of significantly analgesia and anti-cancer and cancer-preventing.
Rhizoma pinellinae praeparata：Classification system Rhizoma Pinelliae are aroid tuber of pinellia Pinellia ternata (Thunb) stem tuber of Breit.；Also known as：The tuber of pinellia processed, preparation method summer, system ground text, eight beans of system ground.It is pungent, warm；Returns spleen, stomach, lung channel.Work( It can cure mainly：It is eliminating dampness and eliminating phlegm；For abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, phlegm and headache.Rhizoma pinellinae praeparata can activate vagus nerve Efferent Activities and there is anti-vomiting effect, moreover it is possible to inhibit pepsin activity, protect stomach lining, promote the reparation of stomach lining, have The effect of anti-rat pyloric ligation ulcer, indocin ulcer and stress ulcer.
Grass-leaved sweetflag：Classification system：Acorus tatarinowii belong to Araeceae, Acorus graminoid perennial herb Plant, rhizome are often made medicinal.Major function：Dampness elimination appetizing, slit phlegm of having one's ideas straightened out, inducing resuscitation intelligence development.For gastral cavity ruffian is not hungry, apnea, Coma epilepsy, forgetfulness and deafness.Qi-regulating, promoting blood circulation, relieve heat are dried.Control epilepsy, coma due to blocking of the respiratory system, pyreticosis coma, forgetful, deafness with qi stagnation, ambition It is unhappy.Volatile oil there are many containing in grass-leaved sweetflag, main component is beta-Asarone, cis- methyl tert-butyl sesame oil phenol, elemicine, Asarylaldehyde, the clear casket alkene of δ-Bi, Thymol and Pork and beans labour acid etc..Research shows that：Asarone in volatile oil is having for calmness Ingredient is imitated, soft extract made of grass-leaved sweetflag rhizome water extract is used clinically for treatment epileptics and other nervous system diseases Suffer from, has good therapeutic effect, volatile oil that there is significant physiological activity to the animal model of certain nervous systems.Grass-leaved sweetflag decoction It is for oral administration to promote the secretion of digestive juice and prevent stomach and intestine abnormal fermentation, and play the role of alleviating intestinal tube smooth muscle spasm.
Radix Notoginseng：For the dry root and rhizome of panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen, Also known as：Pseudo-ginseng, Panax pseudoginseng, radix notoginseng, literary state Radix Notoginseng.Sweet, slight bitter, temperature.Return liver, stomach.Dissipate stasis of blood hemostasis, detumescence ding-tong.With It in spitting of blood, spits blood, bleeding from five sense organs or subcutaneous tissue is had blood in stool, uterine bleeding, traumatic hemorrhage, chest and abdomen shouting pain, tumbling and swelling.
Herba Epimedii：Scientific name：Epimedium brevicornu Maxim., Herba Epimedii acrid-sweet flavor is warm-natured, walks liver kidney two warp, For mend the gate of vitality, strengthening the essence gas, strengthening the bones and muscles, tonifying kidney and strengthening yang key medicine.Impotence and premature ejaculation is cured mainly, pain in low back and legs, numb limb, half body is not Then, neurasthenia, forgetful, tinnitus, dizzy equal diseases.Pharmacological experiment study shows that Herba Epimedii can increase cardiovascular and cerebrovascular blood flow, promotees Into hematopoiesis function, immune function and bone metabolism, there is anti-aging, antitumor and other effects.
Modern research shows that Herba Epimedii containing icariine, volatile oil, ceryl alcohol, phytosterol, tannin, vitamin E etc. at Point.The excited sexual performance of energy, has animal and promotes gonopoiesis effect.Also it is depressured（Cause peripheral vasodilation）, it is hypoglycemic, sharp Urine, kobadrin and the effect of vitamin E sample.Pharmacological experiment study shows that Herba Epimedii can increase cardiovascular and cerebrovascular blood flow, promotes Hematopoiesis function, immune function and bone metabolism have anti-aging, antitumor and other effects.
Sun-dried ginseng：It is dug out together with fibrous root by ginseng Panax ginseng C. A. Mey, cleared soil dries obtained. Sweet in flavor, slight bitter, it is warm-natured, flat.Returns spleen, lung channel, the heart channel of Hang-Shaoyin.Tonifying Qi, prevent prolapse are promoted the production of body fluid, and are calmed the nerves, intelligence development.The fleshy root of ginseng is famous Strong tonic is suitable for adjustment blood pressure, restores cardiac function, neurasthenia and the diseases such as in poor health, also have eliminating the phlegm, stomach invigorating, Diuresis, excitement and other effects.
Rheum officinale：For polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Maxim Rheum tanguticum The drying root and rhizome of Maxim.ex Balf. or Rheum officinale Rheum officinale Baill..Autumn end cauline leaf it is withered or Excavation before secondary spring is germinateed, removes radicula, scrapes off crust, valve cutting or section, and rope wears bunchiness drying or convection drying.With attack it is stagnant, Clearing away damp-heat, purging intense heat, cool blood, dissolving stasis, removing toxic substances and other effects.
The preparation of the five internal organs function of warming yang and gore removing soft extract of the present invention and the method for improving mouthfeel are inventors by multiple The practicable scheme that experimental study comes out, part test method are as follows：
Drug and reagent used：Chinese medicine radix aconiti lateralis preparata, rhizoma zingiberis, Morinda officinalis, cassia twig, rhizoma pinellinae praeparata, grass-leaved sweetflag, Radix Notoginseng, Herba Epimedii, life Ginseng, prepared RADIX ET RHIZOMA RHEI are shone, the first affiliated hospital of Guangxi University of Chinese Medicine is purchased from；Icariin（Lot number 110737-201516）, aconitine （Lot number 112019-201601）：National Institute for Food and Drugs Control；Hypaconitine（Lot number 170623）, mesaconine（Lot number 170620）：Shanghai Tongtian Biotechnology Co., Ltd.；βCyclodextrin（Lot number 20170114）：The limited public affairs of Tianjin hongda chemical industry Department.Sucralose（Lot number F1519040）：Aladdin industrial corporation；Vanillic aldehyde（Lot number 20170311）：Fine chemistry industry research institute is recovered in Tianjin；HPLC grades of methanol（Lot number 166578）：Fisher chemical.Institute Use instrument：1260 type high performance liquid chromatographs, band UV detector, are purchased from Agilent company of the U.S..
1, the five internal organs function of warming yang and gore removing soft extract preparation process flow
It takes Radix Notoginseng, sun-dried ginseng to break into coarse powder, is extracted 2 times with 70% alcohol reflux, 1.5 h, merges alcohol extract every time, filters, recycling Ethyl alcohol obtains alcohol extracting cream.Remaining 8 taste merges with the Radix Notoginseng after alcohol extracting, the sun-dried ginseng dregs of a decoction, and water carries, and is collected simultaneously volatile oil；Aqueous extracts Filtration, concentration, obtains water and carries cream.Alcohol extracting cream and water are carried cream to merge, volatile oil is added, is sufficiently mixed, is usedβCyclodextrin, trichlorine sugarcane Sugar, vanillic aldehyde modulate mouthfeel, with 60% syrup constant volume to get.
2, the content assaying method of icariin
Chromatographic condition：Agilent C18Column（ZORBAX SB-C18 4.6×250mm,5μm）, mobile phase acetonitrile-water（30: 70）, 1.0 mlmin of flow velocity-1, 270 nm of Detection wavelength, 10 μ L of sample size, 30 DEG C of column temperature.Upper machine sample is all molten with methanol Solution and preparation.
3, the TLC discrimination methods of aconitine, Hypaconitine, mesaconine
Contact plate sample is dissolved with dichloromethane, with n-hexane-ethyl acetate-methanol（6.4:3.6:1）For solvent, ammonia steam is set It is saturated in the expansion cylinder of 20 min, is unfolded, take out, dry, spray is developed the color with dilute bismuth potassium iodide test solution.
4, the orthogonal test of extraction process by water
Using L9（34）Orthogonal test with amount of water, decocts number, pan-fried using the rate of extract, the icariin rate of transform as evaluation index It is that influence factor optimizes extraction process by water to boil the time.The factor level table of orthogonal test is as shown in table 1 below.
1 extraction process by water orthogonal test factor level table of table
Evaluation index computational methods：
（1）The rate of extract：Each secondary Aqueous extracts of orthogonal test are merged, filtration is condensed into cream, sets 12h in 105 DEG C of ovens, weigh, The rate of extract is calculated as follows（E）：E%=dry cream weight/medicinal material weight × 100%；By the rate of extract the maximum（Emax）It is set to 100 points, The rate of extract（E）Score value be calculated as follows：R1=E/Emax×100.
（2）The icariin rate of transform：The Icariin content in cassia twig medicinal material and each Aqueous extracts is measured respectively, is thus calculated Go out the amount with icariin in cassia twig medicinal material in Aqueous extracts, the rate of transform is calculated as follows：The amount of icariin in F%=Aqueous extracts/ Amount × 100% of icariin in medicinal material.By rate of transform the maximum（Fmax）It is set to 100 points, the rate of transform（F）Score value as the following formula It calculates：R2=F/Fmax×100.
（3）Weighted average point：The weight of the rate of extract is 40%, and the weight of the icariin rate of transform is 60%, is calculated as follows Weighted average point（G）：G=R1×40%+R2×60%.
Test result and its variance analysis are as shown in the following table 2, table 3.
2 extraction process by water orthogonal experiments of table
3 extraction process by water orthogonal test variance analysis of table
Soruces of variation Sum of squares of deviations Degree of freedom It is square FValue Conspicuousness
A 224.95 2 112.47 3.28
B 827.08 2 413.54 12.08 P<0.1
C（Blank） 68.42 2 34.21
D 520.91 2 260.45 7.61
Note：F 0.1(2,2)=9.00。
As seen from the experiment：Influence extraction process by water factor sequence be：B>D>A, wherein B is more significant influence factor （P<0.1）, optimal to select B3, i.e., boiling is three times；D is minor effect factor, has no statistically significant meaning（P>0.10）, can appoint Choosing；A is minimum influence factor, has no statistically significant meaning（P>0.10）, can be optional.In conjunction with actual production, plan water three times The parameter boiled is set to：A3B3D1、A1B3D1、A1B3D1, i.e. boiling three times, boils 1 hour every time, for the first time plus 15 times of amount water, the Two, third time is respectively plus 10 times are measured water.
5, mouthfeel orthogonal test is modulated
The method that the present invention improves the five internal organs function of warming yang and gore removing soft extract mouthfeel is that β-ring paste is added in the five internal organs function of warming yang and gore removing soft extract Essence, Sucralose, vanillic aldehyde combination are made, and the weight ratio that wherein each component accounts for soft extract is respectively：β-cyclodextrin 5~15%, Sucralose 0.05~0.30%, vanillic aldehyde 0.2~2.0%.
It is experiment process and effect below：
With whole mouthfeel favorable comment degree, the acceptable degree of bitter taste, pungent acceptable degree for evaluation index, with beta-cyclodextrin dosage, trichlorine Dosage of sucrose, vanillic aldehyde dosage are influence factor, design optimization of orthogonal test product mouthfeel.The factor level table of orthogonal test is such as Shown in the following table 4.
Table 4 modulates the factor level table of mouthfeel orthogonal test
Evaluation index computational methods：By 5 male 5 female, totally 10 university students form for scoring group, and mouth is in good taste to the entirety of product after tasting The acceptable degree of degree of commenting, bitter taste, pungent acceptable degree score, and calculate separately the mean value of this three index, are denoted as H, I, J.It will Hmax, Imax, Jmax are respectively set to 100 points, and other score values are calculated as follows：R3=H/Hmax×100；R4=I/Imax×100； R5=J/Jmax×100。
Weighted average point：The weight of whole mouthfeel favorable comment degree is 40%, the weight of the acceptable degree of bitter taste is 30%, pungent is connect The weight spent is 30%, and weighted average point is calculated as follows：K=R3×40%+R4×30%+R5×30%.
Test result and its variance analysis are as shown in the following table 5, table 6.
Table 5 modulates mouthfeel orthogonal experiments
Table 6 modulates mouthfeel orthogonal test variance analysis
Soruces of variation Sum of squares of deviations Degree of freedom It is square FValue Conspicuousness
A 2745.03 2 1372.517 384.18 P<0.01
B 25.027 2 12.51 3.50
C 84.59 2 42.29 11.84 P<0.1
D（Blank） 7.14 2 3.57
Note：F 0.01(2,2)=99.00；F 0.1(2,2)=9.00。
As seen from the experiment：Influence mouthfeel factor sequence be：A>>C>B, wherein A is that pole significantly affects factor（P< 0.01）, optimal to select A3；C is minor effect factor（P<0.05）, optimal to select C3；B is minimum influence factor, has no statistics Notable meaning（P>0.10）, can be optional.Plan Optimal Parameters and is set to A3B1C3, i.e.,βCyclodextrin dosage is 10%, and Sucralose is used Amount is 0.1%, and vanillic aldehyde dosage is 1%.
6, verification test
Production by above-mentioned orthogonal optimization result 3 batches of products of progress and modulation mouthfeel verification, indices such as table 7.Illustrate to optimize As a result feasible, there is good operational stability.Test result is as shown in table 7.
7 orthogonal verification result of table
Batch The rate of extract/% The icariin rate of transform/% Whole mouthfeel favorable comment degree min Bitter taste is subjected to degree min Pungent acceptable degree min
1 15.86 72.34 85.3 75.8 80.6
2 16.12 75.26 81.7 77.1 83.3
3 15.91 73.97 84.5 78.0 78.9
It is average 15.96 73.86 83.83 76.97 80.93
Beneficial effects of the present invention：
The decoction of script is prepared into soft extract by the 1, preparation method of the five internal organs function of warming yang and gore removing soft extract of the present invention, hence it is evident that Its mouthfeel is improved, its whole curative effect is improved, more conducively consumer receives, can expand its application range, overcome decoction volume Larger, bitter, storage and it is inconvenient to carry the deficiencies of place；Made soft extract taste is good, without nauseous uncomfortable when taking Sense, masks itself bitter taste and pungent significantly, up-to-standard.
2, the method for the preparation of the five internal organs function of warming yang and gore removing soft extract of the present invention and improvement mouthfeel, the mouthfeel of addition are adjusted Agent beta-cyclodextrin, which can adsorb, the various chemical substances such as causes bitter taste, pungent, feels sick, and can greatly cover bad mouthfeel；Addition Sucralose be sucrose chlorinated derivatives, sugariness is 400-800 times of sucrose, can competitively be combined with taste bud, reduce Bitter；Vanillic aldehyde has milk breath, is widely used edible spices, can cover foreign odor, reduces bitter taste, overall Reconciliation mouthfeel；Three cooperates with the whole mouthfeel that can substantially improve the five internal organs function of warming yang and gore removing soft extract.
3, the preparation method of the five internal organs function of warming yang and gore removing soft extract of the present invention is divided into alcohol extracting according to the characteristics of each Chinese medicine It is carried with water, the saponin component water solubility in Radix Notoginseng and sun-dried ginseng is not high, and rhizoma zingiberis and grass-leaved sweetflag contain volatile oil.Therefore, Radix Notoginseng Alcohol extracting is first passed through with sun-dried ginseng, the obtained dregs of a decoction again extract together with other medicinal materials by boiling, is more advantageous to the dissolution of active ingredient, The abundant proposition of active ingredient is not only improved, also without losing the volatile oil with good physiological activity.
4, the preparation method of the five internal organs function of warming yang and gore removing soft extract of the present invention, preparation method is simple, obtained soft extracts The adjusting of agent mouthfeel is proper, and the rate of extract is larger, and preparation process is reasonable, up-to-standard after products obtained therefrom inspection, and active constituent content closes Reason, is not detected aconitine, mesaconine and isoaconitine using HPLC methods and TLC methods, meets relevant standard.
5, the five internal organs function of warming yang and gore removing soft extract of the present invention has effects that temperature helps Yuanyang, Eradicates blood stasis and smoothing collaterals, dissipating phlegm for resuscitation, It is mainly used for treating vascular dementia and vertigo, improves immunity, it can also the pre- diseases such as anti-stroke；It is easy to use and carry, Convenient for quantitatively taking, the needs of long-term treatment can be met.
Description of the drawings
Fig. 1 is the technological process of production of the five internal organs function of warming yang and gore removing soft extract.
Specific implementation mode
For the more detailed introduction present invention, with reference to embodiment, the present invention will be further described.Following implementation Example is not any restrictions to the scope of the present invention for illustrating the present invention.
Embodiment 1
The preparation of the five internal organs function of warming yang and gore removing soft extract and the method for improving mouthfeel, the five internal organs function of warming yang and gore removing soft extract is by following heavy The raw material of amount number is made：30 parts of radix aconiti lateralis preparata, 17 parts of rhizoma zingiberis, 16 parts of Morinda officinalis, 16 parts of cassia twig, 15 parts of rhizoma pinellinae praeparata, grass-leaved sweetflag 15 Part, 16 parts of Radix Notoginseng, 16 parts of Herba Epimedii, 15 parts of sun-dried ginseng, 5 parts of rheum officinale；Preparation method includes the following steps：
（1）Alcohol extracting：Radix Notoginseng and sun-dried ginseng are weighed by weight ratio, is crushed, 4 mesh standard sieves are crossed, and the second that volume fraction is 70% is added Alcohol, carries out refluxing extraction 3 times, 1 hour every time, obtains alcohol extract and the alcohol extracting dregs of a decoction, recycles ethyl alcohol after alcohol extract filtering, obtain alcohol Put forward dilute cream；
（2）Water carries：Radix aconiti lateralis preparata, rhizoma zingiberis, Morinda officinalis, cassia twig, rhizoma pinellinae praeparata, grass-leaved sweetflag, Herba Epimedii and rheum officinale are weighed by weight ratio, Chopping, with step（1）The alcohol extracting dregs of a decoction of gained merge, and extract 3 times, boil every time 1.5 hours, and it is dry that all medicinal materials are added for the first time The water that 15 times of weight, second, third each water for being added 12 times；Volatile oil is collected while extraction, merges Aqueous extracts, is filtered, Concentration, obtains water and puies forward dilute cream；
（3）Concentration：By step（1）Alcohol extracting dilute cream and step（2）Water carry dilute cream mixing, being further concentrated into relative density is 1.38, obtain clear cream；
（4）Refine syrup：It takes white granulated sugar appropriate, the water of its weight 60% is added, citric acid and bee is added in ebuillition of heated 20min Honey, infusions 5min on one side stir while, and control total sugar content is 60%；
（5）Prepare finished product：Aseptically, qinghuo reagent, with refining syrup constant volume, heating is tempered 1.5 hours, and control is water-dispersed It loses, it is that volatile oil is added when being cooled to 70 DEG C in 1.42 ranges to make relative density, and mouth feel modifying agents are added and modulate mouthfeel, fully Stirring, vacuum suction eliminate bubble, dispense to get the five internal organs function of warming yang and gore removing soft extract.
The method of above-mentioned improvement mouthfeel is that mouth feel modifying agents are added in soft extract, and the mouth feel modifying agents are pasted by β-ring Essence, Sucralose, vanillic aldehyde combination are made, and wherein each component accounting is respectively：β-cyclodextrin 10%, Sucralose 0.1%, chinese cymbidium Element 0.8%.
Embodiment 2
The preparation of the five internal organs function of warming yang and gore removing soft extract and the method for improving mouthfeel, the five internal organs function of warming yang and gore removing soft extract is by following heavy The raw material of amount number is made：32 parts of radix aconiti lateralis preparata, 14 parts of rhizoma zingiberis, 13 parts of Morinda officinalis, 15 parts of cassia twig, 15 parts of rhizoma pinellinae praeparata, grass-leaved sweetflag 16 Part, 16 parts of Radix Notoginseng, 14 parts of Herba Epimedii, 15 parts of sun-dried ginseng, 6 parts of rheum officinale；Preparation method includes the following steps：
（1）Alcohol extracting：Radix Notoginseng and sun-dried ginseng are weighed by weight ratio, is crushed, 12 mesh standard sieves are crossed, and it is 75% that volume fraction, which is added, Ethyl alcohol, carries out refluxing extraction 2 times, 2 hours every time, obtains alcohol extract and the alcohol extracting dregs of a decoction, recycles ethyl alcohol after alcohol extract filtering, obtain Alcohol extracting dilute cream；
（2）Water carries：Radix aconiti lateralis preparata, rhizoma zingiberis, Morinda officinalis, cassia twig, rhizoma pinellinae praeparata, grass-leaved sweetflag, Herba Epimedii and rheum officinale are weighed by weight ratio, 60 mesh are crushed to, with step（1）The alcohol extracting dregs of a decoction of gained merge, and extract 3 times, boil every time 1 hour, all medicines are added for the first time The water that 15 times of material dry weight, second, third each water for being added 10 times；Volatile oil is collected while extraction, merges Aqueous extracts, mistake Filter, concentration, obtains water and puies forward dilute cream；
（3）Concentration：By step（1）Alcohol extracting dilute cream and step（2）Water carry dilute cream mixing, into one on step be concentrated into relative density 1.35~1.38, obtain clear cream；
（4）Refine syrup：It takes white granulated sugar appropriate, the water of its weight 50% is added, citric acid and bee is added in ebuillition of heated 15min Honey, infusions 3min on one side stir while, and control total sugar content is 68%；
（5）Prepare finished product：Aseptically, qinghuo reagent, with refining syrup constant volume, heating is tempered 1.5 hours, and control is water-dispersed It loses, it is 1.40 to make relative density, and volatile oil is added when being cooled to 80 DEG C, adds mouth feel modifying agents modulation mouthfeel, is sufficiently stirred, Vacuum suction eliminates bubble, dispenses to get the five internal organs function of warming yang and gore removing soft extract.
The method of above-mentioned improvement mouthfeel is that mouth feel modifying agents are added in soft extract, and the mouth feel modifying agents are pasted by β-ring Essence, Sucralose, vanillic aldehyde combination are made, and wherein each component accounting is respectively：β-cyclodextrin 12%, Sucralose 0.13% are fragrant Blue element 1%.
Embodiment 3
The preparation of the five internal organs function of warming yang and gore removing soft extract and the method for improving mouthfeel, the five internal organs function of warming yang and gore removing soft extract is by following heavy The raw material of amount number is made：35 parts of radix aconiti lateralis preparata, 13 parts of rhizoma zingiberis, 15 parts of Morinda officinalis, 15 parts of cassia twig, 16 parts of rhizoma pinellinae praeparata, grass-leaved sweetflag 16 Part, 15 parts of Radix Notoginseng, 15 parts of Herba Epimedii, 17 parts of sun-dried ginseng, 5 parts of rheum officinale；Preparation method includes the following steps：
（1）Alcohol extracting：Radix Notoginseng and sun-dried ginseng are weighed by weight ratio, is crushed, 16 mesh standard sieves are crossed, and it is 70% that volume fraction, which is added, Ethyl alcohol, carries out refluxing extraction 3 times, 1 hour every time, obtains alcohol extract and the alcohol extracting dregs of a decoction, recycles ethyl alcohol after alcohol extract filtering, obtain Alcohol extracting dilute cream；
（2）Water carries：Radix aconiti lateralis preparata, rhizoma zingiberis, Morinda officinalis, cassia twig, rhizoma pinellinae praeparata, grass-leaved sweetflag, Herba Epimedii and rheum officinale are weighed by weight ratio, 60 mesh are crushed to, with step（1）The alcohol extracting dregs of a decoction of gained merge, and extract 2 times, boil every time 2 hours, first, second addition 10 times of water is added in the water of 15 times of all medicinal material dry weights, third time；Volatile oil is collected while extraction, merges Aqueous extracts, mistake Filter, concentration, obtains water and puies forward dilute cream；
（3）Concentration：By step（1）Alcohol extracting dilute cream and step（2）Water carry dilute cream mixing, being further concentrated into relative density is 1.38, obtain clear cream；
（4）Refine syrup：It takes white granulated sugar appropriate, the water of its weight 60% is added, citric acid and bee is added in ebuillition of heated 20min Honey, infusions 3min on one side stir while, and control total sugar content is 65%；
（5）Prepare finished product：Aseptically, qinghuo reagent, with refining syrup constant volume, heating is tempered 2 hours, and control is water-dispersed It loses, it is 1.40 to make relative density, and volatile oil is added when being cooled to 70 DEG C, adds mouth feel modifying agents modulation mouthfeel, is sufficiently stirred, Vacuum suction eliminates bubble, dispenses to get the five internal organs function of warming yang and gore removing soft extract.
The method of above-mentioned improvement mouthfeel is that mouth feel modifying agents are added in soft extract, and the mouth feel modifying agents are pasted by β-ring Essence, Sucralose, vanillic aldehyde combination are made, and wherein each component accounting is respectively：β-cyclodextrin 13%, Sucralose 0.15% are fragrant Blue element 0.15%.

Claims (2)

1. the preparation of the five internal organs function of warming yang and gore removing soft extract and the method for improving mouthfeel, which is characterized in that the five internal organs function of warming yang and gore removing Soft extract is prepared from the following raw materials in parts by weight：25~35 parts of radix aconiti lateralis preparata, 10~20 parts of rhizoma zingiberis, 10~20 parts of Morinda officinalis, osmanthus 10~20 parts of branch, 10~20 parts of rhizoma pinellinae praeparata, 10~20 parts of grass-leaved sweetflag, 10~20 parts of Radix Notoginseng, 10~20 parts of Herba Epimedii, sun-dried ginseng 10 ~20 parts, 3~9 parts of rheum officinale；Preparation method includes the following steps：
（1）Alcohol extracting：Radix Notoginseng and sun-dried ginseng are weighed by weight ratio, is crushed to 5~20 mesh, and it is 60~80% that volume fraction, which is added, Ethyl alcohol, carries out refluxing extraction 2~3 times, 1~2 hour every time, obtains alcohol extract and the alcohol extracting dregs of a decoction, second is recycled after alcohol extract filtering Alcohol obtains alcohol extracting dilute cream；
（2）Water carries：Radix aconiti lateralis preparata, rhizoma zingiberis, Morinda officinalis, cassia twig, rhizoma pinellinae praeparata, grass-leaved sweetflag, Herba Epimedii and rheum officinale are weighed by weight ratio, Chopping, with step（1）The alcohol extracting dregs of a decoction of gained merge, and extract 1~3 time, 10~15 times of all medicinal material dry weights are added every time Water boils 1~3 hour, and extraction while collects volatile oil, merges Aqueous extracts, filters, and concentration obtains water and puies forward dilute cream；
（3）Concentration：By step（1）Alcohol extracting dilute cream and step（2）Water carry dilute cream mixing, be further concentrated into relative density 1.35~1.40, obtain clear cream；
（4）Refine syrup：It takes white granulated sugar appropriate, the water of its weight 40~60% is added, lemon is added in 10~20min of ebuillition of heated Acid and honey, infusion 3~5min on one side stir while, and control total sugar content is 55~70%；
（5）Prepare finished product：Aseptically, qinghuo reagent, with refining syrup constant volume, heating is tempered 1~2 hour, and moisture is controlled It scatters and disappears, makes relative density in 1.38~1.42 ranges, volatile oil is added when being cooled to 60~80 DEG C, mouth feel modifying agents are added and change Kind mouthfeel, is sufficiently stirred, and vacuum suction eliminates bubble, dispenses to get the five internal organs function of warming yang and gore removing soft extract.
2. the preparation method of the five internal organs function of warming yang and gore removing soft extract according to claim 1, which is characterized in that improve the side of mouthfeel Method is that mouth feel modifying agents are added in soft extract, and the mouth feel modifying agents combine system by beta-cyclodextrin, Sucralose, vanillic aldehyde At the weight ratio that wherein each component accounts for soft extract is respectively：β-cyclodextrin 5~15%, Sucralose 0.05~0.30%, chinese cymbidium Element 0.2~2.0%.
CN201810237925.6A 2018-03-22 2018-03-22 The preparation of the five internal organs function of warming yang and gore removing soft extract and the method for improving mouthfeel Pending CN108339101A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110934998A (en) * 2019-12-19 2020-03-31 广西中医药大学第一附属医院 Composition for treating severe dementia, preparation and application thereof
CN110934996A (en) * 2019-12-19 2020-03-31 广西中医药大学第一附属医院 Composition and preparation for treating mild dementia and application thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110934998A (en) * 2019-12-19 2020-03-31 广西中医药大学第一附属医院 Composition for treating severe dementia, preparation and application thereof
CN110934996A (en) * 2019-12-19 2020-03-31 广西中医药大学第一附属医院 Composition and preparation for treating mild dementia and application thereof

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Application publication date: 20180731