CN106361968A - Traditional Chinese medicine tablets and preparation method thereof - Google Patents

Traditional Chinese medicine tablets and preparation method thereof Download PDF

Info

Publication number
CN106361968A
CN106361968A CN201610880282.8A CN201610880282A CN106361968A CN 106361968 A CN106361968 A CN 106361968A CN 201610880282 A CN201610880282 A CN 201610880282A CN 106361968 A CN106361968 A CN 106361968A
Authority
CN
China
Prior art keywords
parts
tablet
pulverize
weight
extract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201610880282.8A
Other languages
Chinese (zh)
Inventor
宋整
宋一整
张泽柏
杜志德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201610880282.8A priority Critical patent/CN106361968A/en
Publication of CN106361968A publication Critical patent/CN106361968A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/52—Juglandaceae (Walnut family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716—Clematis (leather flower)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention belongs to the technical field of traditional Chinese medicine processing and particularly relates to traditional Chinese medicine tablets and a preparation method thereof. The tablets comprise, by weight, 20-30 parts of radix ophiopogonis, 15-30 parts of hairyvein agrimony and 10-20 parts of cyclocarya paliurus. The preparation method includes the steps of raw material smashing, ethanol extraction, high-speed dispersion and emulsification, pressurized extraction and ultrasound combined electric field treatment. Different extraction modes are adopted for different raw materials, and maximum extraction efficiency is achieved; the provided tablets have an obvious treatment effect on conjunctivitis and an obvious effect of reducing blood sugar and have no toxic and side effects on the body, after the tablets are used by patients, no dependence on medicine is generated, and the traditional Chinese medicine is low in price and can be accepted by common people.

Description

A kind of Chinese medicinal tablet and preparation method thereof
Technical field
The invention belongs to processing technique of Chinese herbs field, especially relate to a kind of Chinese medicinal tablet and preparation method thereof.
Background technology
Radix Ophiopogonis, mainly glycosides containing dwarf lilyturf, steroidal saponin, alkaloid, sitosterol, glucose, aminoacid, vitamin etc., had Resisting fatigue, removing free radical, raising cellular immune function and hypoglycemic effect.Contain necessary to human body in Cyclocarya paliurus Iljinskaja The macroelements such as potassium, calcium, magnesium, phosphorus, and also have trace element that body-care is played an important role for example manganese, ferrum, copper, zinc, selenium, Chromium, vitriol, germanium etc..At present how the materials such as Radix Ophiopogonis, Cyclocarya paliurus Iljinskaja are utilized using immersion way, its deep processing and utilization is also needed to Study further.
Content of the invention
Based on this, the present invention provides one kind for Chinese medicinal tablet and preparation method thereof, provides a kind of mouthfeel suitable, effect becomes Code insurance stays the Chinese medicinal tablet of abundant, favourable absorption of human body.
Technical solution of the present invention is:
A kind of be used for Chinese medicinal tablet, described tablet includes following parts by weight of component:
20～30 parts of Radix Ophiopogonis, 15～30 parts of Herba Agrimoniae, 10～20 parts of Cyclocarya paliurus Iljinskaja.
Preferably, described Chinese medicinal tablet also includes following parts by weight of component:
5～10 parts of Caulis Polygoni Multiflori, 5～15 parts of Herba Hyperici Sampsonii, 3～8 parts of Lindernia ruellioides (Colsm.) Pennell, 2～9 parts of Radix Glycyrrhizae, 8～13 parts of bamboo vinegar liquid.
Preferably, described Chinese medicinal tablet also includes following parts by weight of component:
5～7 parts of Chinese clematis leaf, 3～9 parts of Flos Lonicerae, attached column spends 2～8 parts, 4～8 parts of green section of grass.
Preferably, described Chinese medicinal tablet also includes following parts by weight of component:
3～5 parts of Folium Mori, 3～7 parts of Radix seu Folium Alchorneae trewioidis, 3～5 parts of Herba Lycopodii.
The method making described Chinese medicinal tablet, by raw material pulverizing, mixing, tabletting.
Preferably, the method comprising the steps of:
1) weigh raw material components, successively raw material is pulverized respectively with Chinese medicine grinder, each grinding time 2-10 divides Clock, is pulverized with super micron mill after crossing 100 mesh sieves again, standby；
2) by above-mentioned steps 1) pulverize after Radix Ophiopogonis, Herba Agrimoniae is stirred carrying with 80%～95% ethanol of 5-10 times amount Take, after extraction, carry out solid-liquid separation, remove filtering residue concentrating under reduced pressure, drying, dried object is pulverized, obtains material 1；
3) by above-mentioned steps 1) pulverize after Cyclocarya paliurus Iljinskaja, with pure water heating and refluxing extraction 2-3 time of 5-10 times amount, merging Lixiviating solution, by gained lixiviating solution concentrating under reduced pressure, dry, pulverize, obtains material 2；
4) by above-mentioned steps 1) pulverize after Caulis Polygoni Multiflori, Herba Hyperici Sampsonii, Lindernia ruellioides (Colsm.) Pennell, Radix Glycyrrhizae, Chinese clematis leaf, Flos Lonicerae, attached column Colored, green section of grass, Folium Mori, Radix seu Folium Alchorneae trewioidis, Herba Lycopodii, Medulla Junci respectively with 50%～70% alcohol reflux 3～4 times, every time 1.5 ～2.5 hours, united extraction liquid was simultaneously condensed into extractum, concentrating under reduced pressure, dry, pulverize, and obtained material 3；
5) material 1, material 2, material 3 are mixed, smash, add the water of identical weight, put at high speed dispersion emulsifying machine Reason, obtains high speed dispersion and emulsion thing；
6) pressurised extraction: by step 5) process after emulsion, put in pressure pan, add identical weight water, pressurization Then recover normal pressure, filter, obtain extracting solution, and be condensed into extractum, concentrating under reduced pressure, drying, obtain extract；
7) by bamboo vinegar liquid with combination of ultrasound electric field treatment, and it is condensed into extractum, concentrating under reduced pressure, dry, pulverize, cross 80～90 Mesh sieve, obtains bamboo vinegar extract；
8) by described step 6) extract that obtains, described step 7) mixing of bamboo vinegar extract, tabletting；
Complete the making of tablet.
Preferably, methods described also include raw material Cyclocarya paliurus Iljinskaja carry out before pulverizing the efficacy of a drug fermentation pretreatment, its processing method For: by Cyclocarya paliurus Iljinskaja freezing processing, then steam treatment, be dried form efficacy of a drug fermentation Cyclocarya paliurus Iljinskaja and carry out described step 1 again) at pulverizing Reason.
Preferably, -25～-10 DEG C of described freezing processing temperature, freezing processing 3-7h, described vapor (steam) temperature is 60-75 DEG C, Steam pressure is 0.1-0.25mpa, continues 30～35 minutes.
Preferably, described baking temperature is 50-60 DEG C, is dried to moisture below 6%.
Preferably, described step 5) emulsifying rotating speed 2000-3000r/min, time 10-20min.
Preferably, described step 6) it is forced into 3.5～4kg/cm2, and keep 10-15min, then often recover in 1-3s Pressure.
Preferably, described step 7) combination of ultrasound electric field treatment method is: first with frequency 40～60khz, supersound process 5～ 20min, then the Electric Pulse Treatment 5～10min with intensity 5～10kv/cm.
Described tablet carrier includes: stabilizer, diluent, disintegrating agent, solvent, binding agent and lubricant.Wherein diluent Including but not limited to starch, Microcrystalline Cellulose, PEG-6000, PEG-4000, PEG-4000, sucrose, paste Essence, Lactose, Icing Sugar, glucose, low molecular dextran, sodium chloride or Mannitol etc..Described adhesive includes but is not limited to Water, ethanol, starch slurry, syrup, gelatin, methylcellulose, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, sodium alginate Or Polyvinylpyrrolidone etc..Described lubricant include but is not limited to magnesium stearate, stearic acid, boric acid, sodium chloride, enuatrol, Sodium laurylsulfate, pool Lip river sand mother etc..Described disintegrating agent includes but is not limited to starch, carboxymethyl starch sodium, sodium bicarbonate and Chinese holly Rafter acid, tartaric acid or low-substituted hydroxypropyl cellulose etc..Described stabilizer includes but is not limited to polysaccharide such as agar, acrylic acid tree Fat, cellulose ether and carboxymethyl cellulose etc..Described solvent includes water, phosphate buffer, Mannitol, the saline solution of balance Etc..
Radix Ophiopogonis, mainly glycosides containing dwarf lilyturf, steroidal saponin, alkaloid, sitosterol, glucose, aminoacid, vitamin etc., had Resisting fatigue, removing free radical, raising cellular immune function and hypoglycemic effect.In addition, having calmness, hypnosis, the anti-heart Radix Ophiopogonis Myocardial ischemia, arrhythmia, antitumor etc. act on, and especially have many-sided effect to enhancement senior health and fitness.Additionally, Radix Ophiopogonis is also There is promotion islet cell function to recover, increase hepatic glycogen, drop hypoglycemic effect.
Cyclocarya paliurus Iljinskaja (cyclocarya paliurus batal.) is Juglandaceae (juglandaceae) cyclocarya plant, Also known as money tree, numb willow, blue or green Qian Li etc..The macroelement such as potassium, calcium, magnesium, phosphorus necessary to human body is contained in leaf of Cyclocarya paliurus Iljinskaja, and Also has trace element such as manganese, ferrum, copper, zinc, selenium, chromium, vitriol, germanium etc. that body-care is played an important role.Leaf of Cyclocarya paliurus Iljinskaja is China Distinctive natural health care resource, containing a lot of nutritional labelings, can be processed into tea, boiled water brews on behalf of the tea, have well Health-care effect, being capable of blood sugar lowering, lipid-loweringing, blood pressure lowering, enhance immunity etc..
Herba Agrimoniae: latin name agrimoniae herba, bitter in the mouth, puckery, mild-natured, GUIXIN, Liver Channel, there is astringing to arrest bleeding, only Effect of dysentery parasite killing, cures mainly the card of various bleedings, for example: haematemesis, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, labor The de- power of wound, carbuncle, traumatic injury, wound hemorrhage etc. is demonstrate,proved.
Caulis Polygoni Multiflori: sweet in the mouth, mild-natured, GUIXIN, Liver Channel, there is nourishing blood to tranquillize the mind, effect of dispelling wind and removing obstruction in the collateral, cure mainly insomnia and dreamful sleep, Blood deficiency general pain, rheumatic arthralgia；Skin pruritus etc. are demonstrate,proved.Ramulus et Folium Bauhiniae Faberi: latin name euphorbiae hirate herba, mildly bitter flavor, micro- Acid, cool in nature, there is heat-clearing and toxic substances removing, effect of removing dampness through diuresis and relieving itching, for bacillary dysentery, amebic dysentery, enteritis, intestinal infusorian, Dyspepsia, bronchitis, pyelonephritis；The card such as eczema, dermatitis, skin pruritus is controlled in external.
Herba Hyperici Sampsonii: bitter in the mouth, pungent, cold in nature, Return liver, spleen channel, there is removing pathogenic heat from blood and toxic substance from the body, promoting blood flow to regulate menstruation, effect of dispelling wind and removing obstruction in the collateral, master Control various bleedings, enteritis and dysentery, acute mastitis, carbuncle furunculosis, scald, venom, menoxenia, dysmenorrhea, leucorrhea, traumatic injury, wind Pain of dampness syndrome, aphtha etc. is demonstrate,proved.
Lindernia ruellioides (Colsm.) Pennell: sweet in the mouth, light, mild-natured, there is vital energy regualting and blood circulation-promoting, effect of removing toxic substances and promoting subsidence of swelling, cure mainly menoxenia, dysmenorrhea, stomach Bitterly, mastitis, lymphonodi cervicales close, external treatment traumatic injury, and lyssodexiss etc. are demonstrate,proved.
Radix Glycyrrhizae: sweet in the mouth, mild-natured, return 12 warps, have a heat-clearing and toxic substances removing, mediation property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and In, relieving spasm to stop pain, it is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak, the card such as contracture pain in abdomen can be alleviated.
Chinese clematis leaf: pungent, bitter, flat.Sore-throat relieving, removing toxic substances, promoting blood circulation and detumescence.It is clinically used for laryngopharynx swelling and pain, sore throat, throat moth, crane knee joint Wind, hordeolum, the disease such as conjunctivitis.
Flos Lonicerae: sweet, cold, return lung, the heart, stomach.Heat-clearing and toxic substances removing, dispelling wind and heat pathogens.For carbuncle swells furunculosis, toxic-heat and blood stasis.
Attached column is spent: slight bitter, pungent, cool.Heat-clearing and toxic substances removing, removing dampness through diuresis and relieving itching, reducing swelling and alleviating pain.It is clinically used for dysentery, eczema, skin scabies Itch, the disease such as traumatic injury.
Green section of grass: sweet, light, cool.Removing heat from blood removes and steams, removing toxic substances and promoting subsidence of swelling.For dysphoria with smothery sensation, chronic cough, stomachache, conjunctival congestion, fracture, banding bleb Rash etc..
Folium Mori: sweet, bitter, tremble with fear.Return through: return lung, Liver Channel.Indication: dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.For Anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.
Radix seu Folium Alchorneae trewioidis: clearing away heat-damp and promoting diuresis, dissipate stasis of blood hemostasis.For dysentery, dysuria, hematuria, lithangiuria, red collapse, leucorrhea, waist Skelalgia, treating swelling and pain by traumatic injury；Traumatic hemorrhage, urticaria, eczema are controlled in external.
It is the second largest genus of orchid family that Herba Lycopodii belongs to (dendrobium), herbaceos perennial.Herba Lycopodii is famous and precious as one kind Chinese medicine is just included in Compendium of Material Medica, is classified as top grade in Shennong's Herbal, has a reinforcing stomach reg fluid, nourishing YIN and clearing away heat, bright The effects such as mesh profit throat.The Pharmacopoeia of the People's Republic of China is defined as reinforcing stomach reg fluid, the function of nourishing YIN and clearing away heat.It is mainly used in the moon Impairment of body fluid loses, and xerostomia is irritated, and lack of appetite is retched, deficiency-heat after being ill, poor vision.Traditional medicine thinks, Herba Lycopodii has reinforcing stomach reg fluid Effect, modern pharmacological research also demonstrates that, Herba Lycopodii has therapeutical effect for digestive system disease.Pharmacology to Herba Lycopodii in recent years Research and application, in addition to concentrating on to gastrointestinal Effect study, Chinese scholars are to Herba Lycopodii enhancing human body immunity masterpiece With, antitumor action, treatment cataract effect and hypoglycemic activity, antiplatelet aggregative activity etc. had different document reports Road.
Bamboo vinegar liquid is through pyrogenous natural valuable elite by bamboo wood, and it contains more than 200 kind of natural and organic ingredients and ore deposit Material, has that antiphlogistic antibacterial, insect protected be fresh-keeping, a smelly eliminating beauty treatment and other effects.
The present invention has the beneficial effect that:
1st, the tablet in treatment effect that the present invention provides substantially, reaches 94% to the cure rate of conjunctivitis, also can blood sugar lowering, and And body is had no toxic side effect, patient does not produce dependence feeling using rear to medicine, and this Chinese medicine price is relatively low, is ordinary people Acceptable；
2nd, the present invention carries out extraction process to raw material, and the composition finally concentrating carries out tabletting again, improves the activity one-tenth of tablet Divide concentration, improve drug effect；
3rd, it is directed to different raw materials, using different extracting modes, strive for that extraction efficiency maximizes, and to the thing after extracting Material carries out concentrating under reduced pressure, dried, keeps active component.
4th, by Cyclocarya paliurus Iljinskaja freezing processing, freezing can make rapidly cell damage to the present invention, to a certain extent damaged cell Purpose, and relatively improve the damage ratio of cell, improve extraction ratio；And fumigated using steam, remove bad taste, improve The extraction efficiency of Cyclocarya paliurus Iljinskaja；
5th, the present invention adopt HIGH PRESSURE TREATMENT, under high pressure, its result be protein denaturation, starch gelatinization, enzyme inactivation, micro- Biological death, pressure seldom, and is reduced to 0 so that active substance is isolated by moment by nutrition loss, compares existing Technology, effect is good, and the time is short；
6th, material is carried out with emulsifying, the rotor of high speed dispersion emulsifying machine, in high-speed rotation, produces very big centrifugation Power makes processed material spray from the elongated cuts (slit) of rotation, and under the collective effect of stator, makes processed Material is subject to both sides active force: forces it through the positive force of slit and the resistance stoping it from passing through.Meanwhile, it is processed Material when spraying from slit, be also subject to the shear action of slit, and the rotation being produced by turning stator relative motion cut Shear force makes material obtain homogenizing, emulsifying in the presence of multi-acting force.It is narrow, all that the material processing has particle distribution range Evenness is good, no dead angle, the feature by dispersion and emulsion for the material 100%.
7th, the present invention passes through combination of ultrasound electric field treatment, and the harmful components such as the aldehyde in bamboo vinegar liquid are removed, by bamboo vinegar liquid plus Enter in tea, the effect of antibiotic and sterilizing sterilization can be played, the composition beneficial to human body can be retained simultaneously in tea.The present invention can Understand interior free yl rubbish, delay to enhance metabolism, heat clearing away blood sugar lowering, no added.
8th, the present invention utilizes bamboo vinegar liquid, the combination of Flos Lonicerae, Folium Mori and other materials, significantly improves the effect of inhibiting bacteria and diminishing inflammation Really.
Specific embodiment
To further illustrate the present invention with reference to embodiment, but the scope of protection of present invention is not limited to implement The scope of example statement.
Embodiment 1
A kind of Chinese medicinal tablet, described tablet includes following parts by weight of component:
20 parts of Radix Ophiopogonis, 15 parts of Herba Agrimoniae, 10 parts of Cyclocarya paliurus Iljinskaja.
Embodiment 2
A kind of Chinese medicinal tablet, described tablet includes following parts by weight of component:
25 parts of Radix Ophiopogonis, 20 parts of Herba Agrimoniae, 15 parts of Cyclocarya paliurus Iljinskaja.
Embodiment 3
A kind of Chinese medicinal tablet, described tablet includes following parts by weight of component:
25 parts of Radix Ophiopogonis, 20 parts of Herba Agrimoniae, 15 parts of Cyclocarya paliurus Iljinskaja, 8 parts of Caulis Polygoni Multiflori, 12 parts of Herba Hyperici Sampsonii, 5 parts of Lindernia ruellioides (Colsm.) Pennell, Radix Glycyrrhizae 5 Part, 12 parts of bamboo vinegar liquid, 6 parts of Chinese clematis leaf, 7 parts of Flos Lonicerae, attached column spends 7 parts, 6 parts of green section of grass.
Embodiment 4
A kind of Chinese medicinal tablet, described tablet includes following parts by weight of component:
25 parts of Radix Ophiopogonis, 20 parts of Herba Agrimoniae, 15 parts of Cyclocarya paliurus Iljinskaja, 8 parts of Caulis Polygoni Multiflori, 12 parts of Herba Hyperici Sampsonii, 5 parts of Lindernia ruellioides (Colsm.) Pennell, Radix Glycyrrhizae 6 Part, 6 parts of Chinese clematis leaf, 7 parts of Flos Lonicerae, attached column spends 6 parts, 7 parts of green section of grass, 11 parts of Folium Mori, 10 parts of Radix seu Folium Alchorneae trewioidis, 11 parts of Herba Lycopodii, 12 parts of bamboo vinegar liquid.
The method making described Chinese medicinal tablet, the method comprising the steps of:
1) weigh raw material components, successively raw material is pulverized respectively with Chinese medicine grinder, each grinding time 2-10 divides Clock, is pulverized with super micron mill after crossing 100 mesh sieves, fineness is up to 0.006～0.5 μm, standby again；
2) by above-mentioned steps 1) pulverize after Radix Ophiopogonis, Herba Agrimoniae 85% ethanol of 5 times amount be stirred extract, after extraction Carry out solid-liquid separation, remove filtering residue concentrating under reduced pressure, drying, dried object is pulverized, obtains material 1；
3) by above-mentioned steps 1) pulverize after Cyclocarya paliurus Iljinskaja, with pure water heating and refluxing extraction 2-3 time of 8 times amount, merge and soak Extract, by gained lixiviating solution concentrating under reduced pressure, dry, pulverize, obtains material 2；
4) by above-mentioned steps 1) pulverize after Caulis Polygoni Multiflori, Herba Hyperici Sampsonii, Lindernia ruellioides (Colsm.) Pennell, Radix Glycyrrhizae, Chinese clematis leaf, Flos Lonicerae, attached column , respectively with 60% alcohol reflux 4 times, 2 hours every time, united extraction liquid was simultaneously for colored, green section of grass, Folium Mori, Radix seu Folium Alchorneae trewioidis, Herba Lycopodii It is condensed into extractum, concentrating under reduced pressure, dry, pulverize, obtain material 3；
5) material 1, material 2, material 3 are mixed, smash, add the water of mixture identical weight, put into and disperse at a high speed breast Change machine is processed, and obtains high speed dispersion and emulsion thing；
6) pressurised extraction: by step 5) process after emulsion, put in pressure pan, add emulsion identical weight Water, pressurization and then recovery normal pressure, filter, obtain extracting solution, and be condensed into extractum, and concentrating under reduced pressure, drying obtain extract；
7) by bamboo vinegar liquid with combination of ultrasound electric field treatment, and it is condensed into extractum, concentrating under reduced pressure, drying, baking temperature 50-60 DEG C, to moisture below 6%, pulverize, cross 80～90 mesh sieves, obtain bamboo vinegar extract；
8) by described step 6) extract that obtains, described step 7) mixing of bamboo vinegar liquid extract, tabletting, in schistose surface Spraying, by swellable material, obtains tablet；
Complete the making of tablet.
Methods described also includes raw material Cyclocarya paliurus Iljinskaja and carries out efficacy of a drug fermentation pretreatment before pulverizing, and its processing method is: by green grass or young crops Money willow freezing processing, then steam treatment, be dried formed the efficacy of a drug fermentation Cyclocarya paliurus Iljinskaja carry out described step 1 again) pulverization process.
- 25 DEG C of described freezing processing temperature, freezing processing 3h, described vapor (steam) temperature is 60 DEG C, and steam pressure is 0.1mpa, Continue 30 minutes.
Described concentrating under reduced pressure and baking temperature are 50 DEG C, are dried to moisture below 6%.
Described step 5) emulsifying rotating speed 2000r/min, time 10min.
Described step 6) it is forced into 3.5kg/cm2, and keep 10min, in 1s, then recover normal pressure.
Described step 7) combination of ultrasound electric field treatment method is: first with frequency 40khz, supersound process 20min, then use intensity The Electric Pulse Treatment 5min of 10kv/cm.
Described swellable material is acroleic acid resin, and its weight portion is 0.5 part, add 85 DEG C of pure water be configured to 2% molten Spray after liquid.
The clinical observation result of the present embodiment treatment conjunctivitis:
The traditional Chinese medical science thinks that keratoconjunctivitiss are subject to ailment said due to cold or exposure outside being, above attacks in mesh, pathogen contact is popular between eyelid corner of the eyes space between skin and muscles, therefore causes mesh Itch.Find that through clinical practice there is to keratoconjunctivitiss the curative effect of uniqueness, reach the purpose for the treatment of keratoconjunctivitiss.
, in 71 patients of 2012 to 2014 clinical observation keratoconjunctivitiss, clinical report is as follows for the present embodiment Chinese medicine:
1st, physical data
In 81 patients, age 18-65 year, the course of disease many at 1 week to 3 months, 36 years old mean age.
2nd, diagnostic criteria
2.1 carry out clinical diagnosises with reference to the diagnosis basis in " Chinese medical disease Standardization of diagnosis and curative effect ":
Upper tarsal conjunctiva nipple hypertrophy is in flat paving stone sample, or cornea edge glue sample tuberosity；More in conjunctival secretion Eosinophilic granulocyte and the eosinophilic granulocyte's tuberosity being dispersed in.
3rd, Therapeutic Method
The present embodiment tablet, daily 9,3 times a day, is within 7 days 1 course for the treatment of.
4th, therapeutic outcome:
4.1 treatment evaluation criterias, judge according to " Chinese medical disease Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine formulates:
Cure: clinical symptoms and sign all disappear, vision restoration is normal (or vision restoration is to premorbid vision)；
Effective: vision improves, clinical symptoms and sign all disappear；
Effective: clinical symptoms and sign all disappear or partial disappearance or improvement, and vision no improves；
Invalid: vision no improves or clinical symptoms and sign no take a turn for the better or increase.
4.2 results: in 81 patients, 56 (52.1%) of healing, effective 14 (25.4%), effective 10 (21.1%), invalid 1 (1.4%) example, total effective rate is 98.8%.
Model case
1st, Wang, man, 29 years old, right eye was very itched, and recurrent exerbation is more than the moon.Red tongue, stringy pulse is slightly several.Check: hyperemia of the bulbar conjunctiva is black Eyeball central authorities and periphery have the punctate opacity of the cornea of several Semen Sesami sizes.Vision: right eye 0.12, left eye 1.2, examine as keratoconjunctivitiss.2 after medication After the individual course for the treatment of, above-mentioned symptom mitigates, and eye is itched and gone down, and checks that right vision is promoted to 0.8.Continue to take the present embodiment medicine, 1 After the individual course for the treatment of, symptom disappears, and follow-up after a year is no recurred.
2nd, week certain, female, 26 years old, eyes were very itched, now with headache, heating.Check: binocular vision is 1.0, and Dual-eyelid is light Degree swelling, palpebral conjunctiva is congested substantially, and lower eyelid fornix portion has folliculus to be formed, and cornea of left eye has point-like inflammatory infiltration, red tongue.Take 1 course for the treatment of of the present embodiment medicine, daily 1 dose, symptom disappears, and follow-up after a year is no recurred.
3rd, week certain, patient's readme, it once suffers from " pink eye disease " classmate's close contact with part, and originally two have foreign body sensation, Itch, photophobia, shed tears, then eye conjunctiva is more and more redder, gum gets more and more.It is diagnosed as conjunctivitis on inspection.Using the present embodiment Treatment, fully recovered after 3 days.Its father and mother also daily the present embodiment 1 time, 1 ball every time, serve on three days.Follow-up after January, Wang is no Recurrence, its father and mother has no infection.
Embodiment 5
A kind of Chinese medicinal tablet is it is characterised in that described tablet includes following parts by weight of component:
26 parts of Radix Ophiopogonis, 18 parts of Herba Agrimoniae, 13 parts of Cyclocarya paliurus Iljinskaja, 12 parts of Caulis Polygoni Multiflori, 14 parts of Herba Hyperici Sampsonii, 6 parts of Lindernia ruellioides (Colsm.) Pennell, Radix Glycyrrhizae 6 Part, 11 parts of bamboo vinegar liquid, 6 parts of Chinese clematis leaf, 5 parts of Flos Lonicerae, attached column spends 7 parts, 6 parts of green section of grass, 4 parts of Folium Mori, and 7 parts of Radix seu Folium Alchorneae trewioidis are stretched 4 parts of muscle grass.
The method making described Chinese medicinal tablet, the method comprising the steps of:
1) weigh raw material components, successively raw material is pulverized respectively with Chinese medicine grinder, each grinding time 10 minutes, Pulverized with super micron mill again after crossing 100 mesh sieves, standby；
2) by above-mentioned steps 1) pulverize after Radix Ophiopogonis, Herba Agrimoniae 95% ethanol of 10 times amount be stirred extract, extract After carry out solid-liquid separation, remove filtering residue concentrating under reduced pressure, drying, dried object pulverized, obtains material 1；
3) by above-mentioned steps 1) pulverize after Cyclocarya paliurus Iljinskaja, with the pure water heating and refluxing extraction 3 times of 10 times amount, merge extraction Liquid, by gained lixiviating solution concentrating under reduced pressure, dry, pulverize, obtains material 2；
4) by above-mentioned steps 1) pulverize after Caulis Polygoni Multiflori, Herba Hyperici Sampsonii, Lindernia ruellioides (Colsm.) Pennell, Radix Glycyrrhizae, Chinese clematis leaf, Flos Lonicerae, attached column Colored, green section of grass, Folium Mori, Radix seu Folium Alchorneae trewioidis, Herba Lycopodii respectively with 70% alcohol reflux 4 times, 2.5 hours every time, united extraction liquid And it is condensed into extractum, concentrating under reduced pressure, dry, pulverize, obtain material 3；
5) material 1, material 2, material 3 are mixed in proportion, smash, add the pure water of identical weight, put into and divide at a high speed Scattered mulser is processed, and obtains high speed dispersion and emulsion thing；
6) pressurised extraction: by step 5) process after emulsion, put in pressure pan, add identical weight pure water, Pressurization and then recovery normal pressure, filter, obtain extracting solution, and be condensed into extractum, and concentrating under reduced pressure, drying obtain extract；
7) by bamboo vinegar liquid with combination of ultrasound electric field treatment, and it is condensed into extractum, concentrating under reduced pressure, drying, 60 DEG C of baking temperature, To moisture below 6%, pulverize, cross 90 mesh sieves, obtain bamboo vinegar extract；
8) by described step 6) extract that obtains, described step 7) mixing of bamboo vinegar extract, tabletting, in schistose surface spray Apply swellable material, obtain tablet；
Complete the making of tablet.
Methods described also includes raw material Cyclocarya paliurus Iljinskaja and carries out efficacy of a drug fermentation pretreatment before pulverizing, and its processing method is: by green grass or young crops Money willow freezing processing, then steam treatment, be dried formed the efficacy of a drug fermentation Cyclocarya paliurus Iljinskaja carry out described step 1 again) pulverization process.
- 10 DEG C of described freezing processing temperature, freezing processing 7h, described vapor (steam) temperature is 75 DEG C, and steam pressure is 0.25mpa, continues 35 minutes.
Described concentrating under reduced pressure and baking temperature are 60 DEG C, are dried to moisture below 6%.
Described step 5) emulsifying rotating speed 2100r/min, time 13min.
Described step 6) it is forced into 4kg/cm2, and keep 15min, in 3s, then recover normal pressure.
Described step 7) combination of ultrasound electric field treatment method is: first with frequency 60khz, supersound process 20min, then use intensity The Electric Pulse Treatment 10min of 10kv/cm.
Described swellable material is acroleic acid resin, and its weight portion is 0.5 part, add 85 DEG C of pure water be configured to 2% molten Spray after liquid.
The present embodiment is for blood sugar lowering clinical observation result:
1.1 physical data: select the People's Hospital of city outpatient service type 2 diabetes mellitus patient 60, be randomly divided into two groups.Treatment group 30 Example, man 16, female 14,30～70 years old age, average (50 ± 1.5) year, the course of disease 6 months～15 years, average (8.0 ± 1.2) Year；Matched group 30；Man 18；Female 12,29～70 years old age.Two groups of physical data comparing differences not statistically significant (p > 0.05), there is comparability.
1.2 case selections: with reference to World Health Organization's (who) diabetes diagnosis in 1999 and parting standard [1]: diabetes Symptom+random time plasma glucose levels >=11.1mmol/l (200mg/dl).The patient meeting above-mentioned standard is divided at random Group carries out observational study, and the patient partly taking traditional Chinese medicine stops former Chinese medicine and includes observation after 2 weeks, and the patient not taken traditional Chinese medicine is directly brought into sight Examine.Two groups of patients all give Diabetes Foundation to treat, and including diet control, exercise therapy and orally-taken blood sugar reducing Western medicine, blood sugar lowering Western medicine is adopted With metformin, drug usage and dose adjustment are carried out according to blood glucose situation.
1.3 Therapeutic Method: treatment group takes the present embodiment Chinese medicinal tablet on the basis of taking metformin.Every natural gift three Secondary take, 5 grams every time.Matched group routine takes metformin.Two groups are consistent in diet control, exercise therapy, two groups The course for the treatment of is 2 months.
1.4 observation index: measure fasting glucose (fpg), post-prandial glycemia (2hbg), glycolated hemoglobin before and after treatment respectively (hba1c), fasting insulin (fins), blood glucose determination of glucose oxidase, insulin is measured with putting method of exempting from, and blood fat is with entirely Automatic biochemistry analyzer measures, and homa-ir adopts haffner etc. to calculate the formula of ir, i.e. homa-ir=in homa model Fpg × fins/22.5 (fpg unit is mmol/l, and fins unit is mu/l).
1.5 statistical methods: statistical procedures are carried out using spss 14.0 statistical analysis software.Measurement data adopts t to examine Test, enumeration data chi-square criterion.
2 results: before and after two groups of treatments, the change of fpg, 2hbg, hbaic, fins and homa-ir refers to table 1.By in table 1 I Can see, treatment the horizontal comparing difference of front two groups of patients fpg, 2hbg, hbalc, fins, homa-ir not statistically significant (p>0.05)；Before two groups of fpg, 2hbg, hbalc, fins, homa-ir levels and treatment after treatment, comparing difference has statistics to anticipate Adopted (p < 0.05 or p < 0.01), treatment group's patient's These parameters have significant difference (p < 0.01) with comparing before treatment.Treatment group All diabetes glucose can be reduced with matched group, but blood glucose be improved with treatment group and becomes apparent from.
The change of fpg, 2hbg, hbalc, fins and homa-ir before and after 1 liang of group patient's treatment of table
Note: indices compared with pre-treatment: * p < 0.05, * * p < 0.01；After treatment, two groups of fins and homa-ir compare ^ P < 0.05, ^^p < 0.01.
Embodiment 6
A kind of Chinese medicinal tablet is it is characterised in that described tablet includes following parts by weight of component:
26 parts of Radix Ophiopogonis, 18 parts of Herba Agrimoniae, 15 parts of Cyclocarya paliurus Iljinskaja, 6 parts of Caulis Polygoni Multiflori, 12 parts of Herba Hyperici Sampsonii, 4 parts of Lindernia ruellioides (Colsm.) Pennell, Radix Glycyrrhizae 6 Part, 12 parts of bamboo vinegar liquid, 6 parts of Chinese clematis leaf, 4 parts of Flos Lonicerae, attached column spends 6 parts, 7 parts of green section of grass, 4 parts of Folium Mori, and 5 parts of Radix seu Folium Alchorneae trewioidis are stretched 4 parts of muscle grass.
The method making described Chinese medicinal tablet, the method comprising the steps of:
1) weigh raw material components, successively raw material is pulverized respectively with Chinese medicine grinder, each grinding time 2 minutes, Pulverized with super micron mill again after crossing 100 mesh sieves, standby；
2) by above-mentioned steps 1) pulverize after Radix Ophiopogonis, Herba Agrimoniae 80% ethanol of 5 times amount be stirred extract, after extraction Carry out solid-liquid separation, remove filtering residue concentrating under reduced pressure, drying, dried object is pulverized, obtains material 1；
3) by above-mentioned steps 1) pulverize after Cyclocarya paliurus Iljinskaja, with the pure water heating and refluxing extraction 2 times of 5 times amount, merge extraction Liquid, by gained lixiviating solution concentrating under reduced pressure, dry, pulverize, obtains material 2；
4) by above-mentioned steps 1) pulverize after Caulis Polygoni Multiflori, Herba Hyperici Sampsonii, Lindernia ruellioides (Colsm.) Pennell, Radix Glycyrrhizae, Chinese clematis leaf, Flos Lonicerae, attached column Colored, green section of grass, Folium Mori, Radix seu Folium Alchorneae trewioidis, Herba Lycopodii respectively with 50% alcohol reflux 3 times, 1.5 hours every time, united extraction liquid And it is condensed into extractum, concentrating under reduced pressure, dry, pulverize, obtain material 3；
5) material 1, material 2, material 3 are mixed in proportion, smash, add the water of mixture identical weight, put at a high speed Dispersion emulsifying machine is processed, and obtains high speed dispersion and emulsion thing；
6) pressurised extraction: by step 5) process after emulsion, put in pressure pan, add emulsion identical weight Water, pressurization and then recovery normal pressure, filter, obtain extracting solution, and be condensed into extractum, and concentrating under reduced pressure, drying obtain extract；
7) by bamboo vinegar liquid with combination of ultrasound electric field treatment, and it is condensed into extractum, concentrating under reduced pressure, drying, 50 DEG C of baking temperature, To moisture below 6%, pulverize, cross 80 mesh sieves, obtain bamboo vinegar extract；
8) by described step 6) extract that obtains, described step 7) mixing of bamboo vinegar extract, tabletting；
Complete the making of tablet.
Methods described also includes raw material Cyclocarya paliurus Iljinskaja and carries out efficacy of a drug fermentation pretreatment before pulverizing, and its processing method is: by green grass or young crops Money willow freezing processing, then steam treatment, be dried formed the efficacy of a drug fermentation Cyclocarya paliurus Iljinskaja carry out described step 1 again) pulverization process.
- 25 DEG C of described freezing processing temperature, freezing processing 3h, described vapor (steam) temperature is 60 DEG C, and steam pressure is 0.1mpa, Continue 30 minutes.
Described concentrating under reduced pressure and baking temperature are 50 DEG C, are dried to moisture below 6%.
Described step 6) it is forced into 3.5kg/cm2, and keep 10min, in 1s, then recover normal pressure.
Described step 7) combination of ultrasound electric field treatment method is: first with frequency 40khz, supersound process 5min, then use intensity The Electric Pulse Treatment 5min of 5kv/cm.
The present embodiment In vitro Bactericidal Experiments
Trial drug: the Chinese medicinal tablet in embodiment 6.
Method: this present embodiment Chinese medicinal tablet is measured to escherichia coli, golden yellow Portugal using micro continuous doubling dilution Grape coccus, Pseudomonas aeruginosas, staphylococcus epidermidiss, proteus vulgaris, the mark bacterial strain of streptococcus faecalis and escherichia coli, gold Staphylococcus aureus, Pseudomonas aeruginosas, staphylococcus epidermidiss, proteus vulgaris, the minimum of streptococcus faecalis clinical separation strain Mlc (mic), measures Chinese medicine in the present embodiment minimal bactericidal concentration to above-mentioned antibacterial using flat board infection protocol (mbc).By escherichia coli, staphylococcus aureuses, Pseudomonas aeruginosas, staphylococcus epidermidiss, proteus vulgaris, it is inoculated in Mh meat soup, puts 37 DEG C of culture 24h of standard incubator；Streptococcus faecalis are inoculated in tpy meat soup (anaerobe nutrient broth), put anaerobism training Foster 37 DEG C of culture 48h of case.
The least concentration that bacterial growth in culture medium can be suppressed is minimal inhibitory concentration (minimal inhibitory Concentration, mic).During killing antibacterial for evaluation criteria, total viable count is made to reduce 99% or more than 99.5%, referred to as Minimal bactericidal concentration (minimal bactericidal concentration, mbc).A collection of experiment in can suppress 50% or Mic needed for 90% tested bacterium, is referred to as mic50And mic90.The bacteriostasis of antimicrobial drug are relative with bactericidal action, and some resist Bacterium medicine is in bacteriostasis in low concentration, and high concentration is in bactericidal action.
Mic and mbc to reference culture for the table 2 the present embodiment Chinese medicinal tablet
Bacterial strain Mic (mg compositionss/ml) Mbc (mg compositionss/ml)
Escherichia coli atcc25922 strain 11.7 23.4
Staphylococcus aureuses atcc25922 strain 0.42 0.94
Pseudomonas aeruginosas atcc25922 strain 55 109
Staphylococcus epidermidiss atcc25922 strain 0.48 0.97
49010 plants of proteus vulgaris 29 64
32221 plants of streptococcus faecalis 0.43 1.70
From upper table 2, the present embodiment Chinese medicinal tablet is to selected escherichia coli of test, staphylococcus aureuses, green Pus pseudomonass, staphylococcus epidermidiss, proteus vulgaris, streptococcus faecalis be clinically separated Reference Strains all have obvious suppression and Deactivation, its mbc is 2～4 times of mic.
Table 3 is the present embodiment Chinese medicinal tablet mic, mic to 265 plants of Clinical isolation50、mic99(mg combines with mbc Thing/ml)
Mic and mbc to reference culture for the table 3 the present embodiment pharmaceutical composition
Bacterial strain Strain number mic mic50 mic99 mbc
Staphylococcus aureuses 100 0.40～1.47 1.032 1.31 0.75～6.31
Escherichia coli 110 6.39～48 17.861 22.146 30～800
Staphylococcus epidermidiss 30 0.35～3.12 0.712 1.4808 1.58～6.36
Proteus vulgaris 25 11.4～49 25.454 33.0531 35～88
From upper table 3, the present embodiment pharmaceutical composition 265 plant Clinical isolation selected to test all have necessarily Suppression and deactivation, its mbc is 2～4 times of mic.
When removing bamboo vinegar liquid or Flos Lonicerae or Folium Mori in Chinese medicinal components in the present embodiment, carry out with the present embodiment fungistatic effect Relatively, measure inhibitory action mic (mg compositionss/ml) to bacterial strain.Comparing result is shown in Table 4.
Specifically comparative example is,
Comparative example 1: a kind of Chinese medicinal tablet is it is characterised in that described tablet includes following parts by weight of component:
26 parts of Radix Ophiopogonis, 18 parts of Herba Agrimoniae, 15 parts of Cyclocarya paliurus Iljinskaja, 6 parts of Caulis Polygoni Multiflori, 12 parts of Herba Hyperici Sampsonii, 4 parts of Lindernia ruellioides (Colsm.) Pennell, Radix Glycyrrhizae 6 Part, 12 parts of bamboo vinegar liquid, 6 parts of Chinese clematis leaf, attached column spends 6 parts, 7 parts of green section of grass, 4 parts of Folium Mori, 5 parts of Radix seu Folium Alchorneae trewioidis, 4 parts of Herba Lycopodii.
Comparative example 2: a kind of Chinese medicinal tablet is it is characterised in that described tablet includes following parts by weight of component:
26 parts of Radix Ophiopogonis, 18 parts of Herba Agrimoniae, 15 parts of Cyclocarya paliurus Iljinskaja, 6 parts of Caulis Polygoni Multiflori, 12 parts of Herba Hyperici Sampsonii, 4 parts of Lindernia ruellioides (Colsm.) Pennell, Radix Glycyrrhizae 6 Part, 6 parts of Chinese clematis leaf, 4 parts of Flos Lonicerae, attached column spends 6 parts, 7 parts of green section of grass, 4 parts of Folium Mori, 5 parts of Radix seu Folium Alchorneae trewioidis, 4 parts of Herba Lycopodii.
Comparative example 3: a kind of Chinese medicinal tablet is it is characterised in that described tablet includes following parts by weight of component:
26 parts of Radix Ophiopogonis, 18 parts of Herba Agrimoniae, 15 parts of Cyclocarya paliurus Iljinskaja, 6 parts of Caulis Polygoni Multiflori, 12 parts of Herba Hyperici Sampsonii, 4 parts of Lindernia ruellioides (Colsm.) Pennell, Radix Glycyrrhizae 6 Part, 12 parts of bamboo vinegar liquid, 6 parts of Chinese clematis leaf, 4 parts of Flos Lonicerae, attached column spends 6 parts, 7 parts of green section of grass, 5 parts of Radix seu Folium Alchorneae trewioidis, 4 parts of Herba Lycopodii.
Comparative example 4: a kind of Chinese medicinal tablet is it is characterised in that described tablet includes following parts by weight of component:
26 parts of Radix Ophiopogonis, 18 parts of Herba Agrimoniae, 15 parts of Cyclocarya paliurus Iljinskaja, 6 parts of Caulis Polygoni Multiflori, 12 parts of Herba Hyperici Sampsonii, 4 parts of Lindernia ruellioides (Colsm.) Pennell, Radix Glycyrrhizae 6 Part, 6 parts of Chinese clematis leaf, attached column spends 6 parts, 7 parts of green section of grass, 5 parts of Radix seu Folium Alchorneae trewioidis, 4 parts of Herba Lycopodii.
Contrast on effect to the mic of reference culture in table 4 the present embodiment component
As shown in Table 4, for having fungistatic effect, both are joined with other components for the bamboo vinegar liquid in prescription, Flos Lonicerae, Folium Mori Close and use, effect is optimum.
Choosing has the crowd totally 200 of various oral cavities malaise symptoms, and the wherein personnel based on oral ulcer symptom have 110, The personnel of laryngopharynx swelling and pain symptom have 90, take the Chinese medicinal tablet of the present embodiment to above-noted persons, and instructions of taking is: three times a day, 5mg every time.Continuously take observed result after the week, in 110 of oral ulcer symptom, have 100 feels pain substantially to subtract Gently, ulcer surface is no longer rubescent, and remaining personnel's feels pain slightly mitigates, and effect is less obvious, and effective percentage is 90.1%.Swelling throat In 90 of pain, 75 pain are had substantially to mitigate, remaining personnel's sensory effect is inconspicuous, effective percentage is 83%.
The above embodiments are only the preferred technical solution of the present invention, and are not construed as the restriction for the present invention, this Shen Please in embodiment and the feature in embodiment in the case of not conflicting, can mutual combination in any.The protection model of the present invention Enclose the technical scheme that should record with claim, the equivalent side of technical characteristic in the technical scheme recorded including claim Case is protection domain.I.e. equivalent within this range is improved, also within protection scope of the present invention.

Claims (10)

1. a kind of Chinese medicinal tablet is it is characterised in that described tablet includes following parts by weight of component:
20 ~ 30 parts of Radix Ophiopogonis, 15 ~ 30 parts of Herba Agrimoniae, 10 ~ 20 parts of Cyclocarya paliurus Iljinskaja.
2. according to claim 1 Chinese medicinal tablet it is characterised in that described tablet also includes following parts by weight of component:
5 ~ 10 parts of Caulis Polygoni Multiflori, 5 ~ 15 parts of Herba Hyperici Sampsonii, 3 ~ 8 parts of Lindernia ruellioides (Colsm.) Pennell, 2 ~ 9 parts of Radix Glycyrrhizae, 8 ~ 13 parts of bamboo vinegar liquid.
3. according to claim 2 Chinese medicinal tablet it is characterised in that described tablet also includes following parts by weight of component:
5 ~ 7 parts of Chinese clematis leaf, 3 ~ 9 parts of Flos Lonicerae, attached column spends 2 ~ 8 parts, 4 ~ 8 parts of green section of grass.
4. according to claim 3 Chinese medicinal tablet it is characterised in that described tablet also includes following parts by weight of component:
3 ~ 5 parts of Folium Mori, 3 ~ 7 parts of Radix seu Folium Alchorneae trewioidis, 3 ~ 5 parts of Herba Lycopodii.
5. make claim 4 described in Chinese medicinal tablet method it is characterised in that: the method comprising the steps of:
1) weigh raw material components, successively raw material is pulverized respectively with Chinese medicine grinder, each grinding time 2-10 minute, mistake Pulverized with super micron mill again after 100 mesh sieves, standby；
2) by above-mentioned steps 1) pulverize after Radix Ophiopogonis, Herba Agrimoniae 80% ~ 95% ethanol of 5-10 times of weight be stirred extract, carry Carry out solid-liquid separation after taking, remove filtering residue concentrating under reduced pressure, drying, dried object is pulverized, obtains material 1；
3) by above-mentioned steps 1) pulverize after Cyclocarya paliurus Iljinskaja, with water heating and refluxing extraction 2-3 time of 5-10 times of weight, merge and extract Liquid, by gained lixiviating solution concentrating under reduced pressure, dry, pulverize, obtains material 2；
4) by above-mentioned steps 1) pulverize after Caulis Polygoni Multiflori, Herba Hyperici Sampsonii, Lindernia ruellioides (Colsm.) Pennell, Radix Glycyrrhizae, Chinese clematis leaf, Flos Lonicerae, attached column flower, green Section grass, Folium Mori, Radix seu Folium Alchorneae trewioidis, Herba Lycopodii respectively with 50% ~ 70% alcohol reflux 3 ~ 4 times, 1.5 ~ 2.5 hours every time, merging Extracting solution is simultaneously condensed into extractum, concentrating under reduced pressure, dry, pulverize, and obtains material 3；
5) material 1, material 2, material 3 are mixed, smash, add the water of mixture identical weight, put into high speed dispersion emulsifying machine Process, obtain high speed dispersion and emulsion thing；
6) pressurised extraction: the emulsion after step 5) is processed, put in pressure pan, add the water of emulsion identical weight, plus Pressure and then recovery normal pressure, filter, obtain extracting solution, and be condensed into extractum, and concentrating under reduced pressure, drying obtain extract；
7) by bamboo vinegar liquid with combination of ultrasound electric field treatment, and it is condensed into extractum, concentrating under reduced pressure, dry, pulverize, cross 80 ~ 90 mesh sieves, Obtain bamboo vinegar extract；
8) extract that described step 6) obtained, the mixing of described step 7) bamboo vinegar liquid extract, tabletting；
Complete the making of tablet.
6. method according to claim 5 it is characterised in that: methods described also includes raw material Cyclocarya paliurus Iljinskaja and carries out before pulverizing Efficacy of a drug fermentation pretreatment, its processing method is: by Cyclocarya paliurus Iljinskaja freezing processing, then steam treatment, the blue or green money of dry formation efficacy of a drug fermentation Willow carries out described step 1) pulverization process again.
7. method according to claim 6 it is characterised in that: -25～-10 DEG C of described freezing processing temperature, freezing processing 3-7 h, described vapor (steam) temperature is 60-75 DEG C, and steam pressure is 0.1-0.25mpa, continues 30 ~ 35 minutes.
8. method according to claim 5 it is characterised in that: described baking temperature be 50-60 DEG C, be dried to moisture Less than 6%.
9. method according to claim 5 it is characterised in that: described step 6) is forced into 3.5 ~ 4 kg/cm2, and keep 10-15min, then recovers normal pressure in 1-3s.
10. method according to claim 5 it is characterised in that: described step 7) combination of ultrasound electric field treatment method is: first With frequency 40 ~ 60khz, supersound process 5 ~ 20min, then Electric Pulse Treatment 5 ~ 10 min with intensity 5 ~ 10kv/cm.
CN201610880282.8A 2016-10-08 2016-10-08 Traditional Chinese medicine tablets and preparation method thereof Withdrawn CN106361968A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610880282.8A CN106361968A (en) 2016-10-08 2016-10-08 Traditional Chinese medicine tablets and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610880282.8A CN106361968A (en) 2016-10-08 2016-10-08 Traditional Chinese medicine tablets and preparation method thereof

Publications (1)

Publication Number Publication Date
CN106361968A true CN106361968A (en) 2017-02-01

Family

ID=57895252

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610880282.8A Withdrawn CN106361968A (en) 2016-10-08 2016-10-08 Traditional Chinese medicine tablets and preparation method thereof

Country Status (1)

Country Link
CN (1) CN106361968A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110201416A (en) * 2019-06-13 2019-09-06 温州科技职业学院 A kind of blue or green money willow impulse electric field extraction element

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1868521A (en) * 2005-05-27 2006-11-29 张言军 Traditional Chinese medicine tablet for treating medical arthralgia-syndrome and its prepn. method
CN1883644A (en) * 2005-06-21 2006-12-27 杨次龄 Chinese medicinal tablet for treating gynecological disease and preparation process thereof
CN104758369A (en) * 2015-04-28 2015-07-08 张红 Traditional Chinese medicine combination and preparing method and application thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1868521A (en) * 2005-05-27 2006-11-29 张言军 Traditional Chinese medicine tablet for treating medical arthralgia-syndrome and its prepn. method
CN1883644A (en) * 2005-06-21 2006-12-27 杨次龄 Chinese medicinal tablet for treating gynecological disease and preparation process thereof
CN104758369A (en) * 2015-04-28 2015-07-08 张红 Traditional Chinese medicine combination and preparing method and application thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110201416A (en) * 2019-06-13 2019-09-06 温州科技职业学院 A kind of blue or green money willow impulse electric field extraction element

Similar Documents

Publication Publication Date Title
CN101269153A (en) Sobering-up composition and preparation method thereof
CN101569739B (en) Traditional Chinese medicine composition for treating cholecystitis and preparation method thereof
CN102886014B (en) Anticancer drug capable of clearing blood and diminishing inflammation
CN102847061B (en) Traditional Chinese medicine preparation for treating pediatric viral myocarditis and preparation method thereof
CN104547220A (en) Traditional Chinese medicine composition for treating visual fatigue of children and preparation for traditional Chinese medicine composition
CN104383288A (en) Pharmaceutical composition for treating bovine pneumonia and preparation method of pharmaceutical composition for treating bovine pneumonia
CN103520318A (en) Traditional Chinese medicine composition of enhancing immune function and preparation method of composition
CN106344829A (en) Traditional Chinese medicine composition and production method thereof
CN105943953A (en) Health product for treating diabetes and preparation method thereof
CN105435197A (en) Pharmaceutical composition for treating chronic lymphocytic thyroiditis and preparation method thereof
CN102357151B (en) Chinese medicinal composition for delaying senility and preparation process thereof
CN106361968A (en) Traditional Chinese medicine tablets and preparation method thereof
CN104431061A (en) Tea with functions of reducing blood sugar and losing weight and production method thereof
CN103768570B (en) A kind of Chinese medicine composition for the treatment of acute cholecystitis and preparation method thereof
CN103099885A (en) Soft capsules having acne removing function and preparation method thereof
CN102988747B (en) Aristida triseta electuary for reducing hypertension, hyperglycemia and hyperlipidemia and preparation method thereof
CN106344676A (en) Traditional Chinese medicine tablets with blood glucose reducing effect and manufacturing method thereof
CN111603522A (en) Chili leaf composition with blood sugar reducing effect and preparation method and application thereof
CN104306817A (en) Pharmaceutical composition for treating ephemeral fever of dairy cow and preparation method thereof
CN104906502A (en) Pharmaceutical composition for treatment of chicken damaged by heat and preparation method thereof
CN106344655A (en) Traditional Chinese medicinal composition with blood glucose reducing effect and manufacturing method thereof
CN107308254A (en) Eight positives and preparation method thereof
CN102091227B (en) Chinese medicinal preparation for treating swelling and pain in throat and preparation method thereof
CN103690771B (en) Be used for the treatment of medicine of lamb colibacillosis and preparation method thereof
CN103239673B (en) Traditional Chinese medicine composition for preventing and curing sudden death syndrome of cow

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20170201