CN106344655A - Traditional Chinese medicinal composition with blood glucose reducing effect and manufacturing method thereof - Google Patents

Traditional Chinese medicinal composition with blood glucose reducing effect and manufacturing method thereof Download PDF

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Publication number
CN106344655A
CN106344655A CN201610880284.7A CN201610880284A CN106344655A CN 106344655 A CN106344655 A CN 106344655A CN 201610880284 A CN201610880284 A CN 201610880284A CN 106344655 A CN106344655 A CN 106344655A
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parts
rhizoma polygonati
chinese medicine
raw material
blood glucose
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郑国�
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Hubei Sanxia Shennong Biological Science And Technology Co Ltd
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Hubei Sanxia Shennong Biological Science And Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/62—Nymphaeaceae (Water-lily family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention belongs to the technical field of traditional Chinese medicine processing, and particularly relates to a traditional Chinese medicinal composition with a blood glucose reducing effect and a manufacturing method thereof. The composition is prepared from the following raw material components in parts by weight: 10 to 20 parts of cuscutae semen, 3 to 6 parts of white poria cocos, 3 to 6 parts of semen nelumbinis and 5 to 7 parts of fructus schisandrae. The manufacturing method comprises the following steps: crushing the raw materials, performing alcohol extraction, dispersing and emulsifying at a high speed, extracting under an increased pressure, and treating by combining ultrasound and an electric field. According to the traditional Chinese medicinal composition with the blood glucose reducing effect and the manufacturing method thereof, for different raw materials, different extracting modes are adopted for fighting for the maximization of extracting efficiency; the provided composition has an obvious treatment effect of reducing blood glucose, and does not have toxic or side effect on human bodies; a patient does not have a dependence feeling on the composition after using the composition; moreover, the traditional Chinese medicine is low in cost and can be accepted by common people.

Description

A kind of have Chinese medicine composition of effect of lowering blood sugar and preparation method thereof
Technical field
The invention belongs to processing technique of Chinese herbs field, especially relate to a kind of Chinese medicine composition with effect of lowering blood sugar and Its manufacture method.
Background technology
With the raising of people's living standard, take in the nutrient substance such as substantial amounts of fat, starch in diet, cause Substantial amounts of overweight, obese people, and then occur in that the " three high " class disease such as hyperglycemia, hyperlipidemia, hypertension, the life giving people Bring more detrimental effect with economic situation.China's current " three high " crowd's ratio is in a high position, needs by diet etc. Method is controlled.There is reduction blood glucose, the compound health-care food of regulation blood fat shows good fall " three high " effect.
Content of the invention
Based on this, the present invention provides one kind for Chinese medicine composition and preparation method thereof, provides a kind of mouthfeel suitable, effect Composition retains the Chinese medicine composition of abundant, favourable absorption of human body.
Technical solution of the present invention is:
A kind of Chinese medicine composition with effect of lowering blood sugar, described compositionss include following raw material component:
10～20 parts of Semen Cuscutae, 3～6 parts of Poria, 3～6 parts of Semen Nelumbinis, 5～7 parts of Fructus Schisandrae Chinensis.
Preferably, described compositionss also include following raw material component:
10～15 parts of Caulis Polygoni Multiflori, 3～10 parts of Hubei Chinese flowering crabapple, 8～13 parts of bamboo vinegar liquid.
Preferably, described compositionss also include following raw material component:
5～15 parts of Radix Puerariae, 3～12 parts of Rhizoma Polygonati Odorati, 5～7 parts of Rhizoma Polygonati.
The method making described Chinese medicine composition, the method comprising the steps of:
1) weigh raw material components, successively raw material is pulverized respectively with Chinese medicine grinder, each grinding time 2-10 divides Clock, is pulverized with super micron mill after crossing 100 mesh sieves again, standby；
2) by above-mentioned steps 1) pulverize after Semen Cuscutae, Poria, entered with 80%～95% ethanol of its 5-10 times of weight Row stirring is extracted, and carries out solid-liquid separation after extraction, removes filtering residue concentrating under reduced pressure, drying, dried object is pulverized, obtains material 1；
3) by above-mentioned steps 1) pulverize after Semen Nelumbinis, Fructus Schisandrae Chinensis, with water heating and refluxing extraction 2-3 of its 5-10 times of weight Secondary, merge lixiviating solution, by gained lixiviating solution concentrating under reduced pressure, dry, pulverize, obtain material 2；
4) by above-mentioned steps 1) pulverize after Caulis Polygoni Multiflori, Hubei Chinese flowering crabapple add cold distilled water solution, then carry out ultralow temperature Lyophilization drying is less than 7% to moisture, obtains material 3；
5) material 1, material 2, material 3 are mixed, smash, add the water of mixture identical weight, put into and disperse at a high speed breast Change machine is processed, and obtains high speed dispersion and emulsion thing；
6) pressurised extraction: by step 5) process after emulsion, put in pressure pan, add emulsion identical weight Water, pressurization and then recovery normal pressure, filter, obtain extracting solution, and be condensed into extractum, and concentrating under reduced pressure, drying obtain extract；
7) Radix Puerariae is stacked 2-6 days at 10～20 DEG C, and lyophilizing is pulverized；Add the organic solvent of its 5～10 times of weight, carry out Ultrasonic-microwave cooperating extracts, and the filtrate cryoconcentration being filtrated to get obtains concentrated solution, then is dried, and dried object is carried out powder Broken, obtain material 4；
8) carry out lyophilization, pulverization process by after Rhizoma Polygonati Odorati, Rhizoma Polygonati section, obtain Rhizoma Polygonati Odorati powder, Rhizoma Polygonati powder；
9) by bamboo vinegar liquid with combination of ultrasound electric field treatment, and it is condensed into extractum, concentrating under reduced pressure, dry, pulverize, cross 80～90 Mesh sieve, obtains bamboo vinegar liquid extract；
10) by described step 6) extract that obtains, described step 7) material 4, step 8) Rhizoma Polygonati Odorati powder, Rhizoma Polygonati powder, step 9) mixing of bamboo vinegar liquid extract, tabletting；
Complete the making of compositionss.
Preferably, methods described also include raw material Caulis Polygoni Multiflori, Hubei Chinese flowering crabapple carry out before pulverizing the efficacy of a drug fermentation pretreatment, its Processing method is: by Caulis Polygoni Multiflori, Hubei Chinese flowering crabapple freezing processing, then steam treatment, the dry formation efficacy of a drug green Caulis Polygoni Multiflori of fermentation, Hubei Caulis et folium euphorbiae milii carries out described step 1 again) pulverization process.
Preferably, described baking temperature is 50-60 DEG C, is dried to moisture below 6%.
Preferably, described step 4) also comprise the resistant dextrin, 12%～18% that concentration is 3%～20% in cold distilled water Sucralose, cold distilled water temperature be 4～25 DEG C, -8 DEG C～-45 DEG C of lyophilization temperature.
Preferably, described step 5) emulsifying rotating speed 2000-3000r/min, time 10-20min.
Preferably, described step 6) it is forced into 3.5～4kg/cm2, and keep 10-15min, then often recover in 1-3s Pressure.
Preferably, described step 7) organic solvent is the ethanol that volumetric concentration is 50%～85%, ultrasonic-microwave cooperating carries The condition taking is: microwave power 210～460w, ultrasonic power 310～550w, 26～36 DEG C of temperature, carries out ultrasonic-microwave association With extraction 400～1300s.
Preferably, described step 9) combination of ultrasound electric field treatment method is: first with frequency 40～60khz, supersound process 5～ 20min, then the Electric Pulse Treatment 5～10min with intensity 5～10kv/cm.
Described compound preparation includes tablet or granule or capsule.
Described preparation agent carrier includes: stabilizer, diluent, disintegrating agent, solvent, binding agent and lubricant.Wherein dilute Agent include but is not limited to starch, Microcrystalline Cellulose, PEG-6000, PEG-4000, PEG-4000, sucrose, Dextrin, Lactose, Icing Sugar, glucose, low molecular dextran, sodium chloride or Mannitol etc..Described adhesive includes but does not limit Yu Shui, ethanol, starch slurry, syrup, gelatin, methylcellulose, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, alginic acid Sodium or Polyvinylpyrrolidone etc..Described lubricant includes but is not limited to magnesium stearate, stearic acid, boric acid, sodium chloride, Oleic acid Sodium, sodium laurylsulfate, pool Lip river sand mother etc..Described disintegrating agent include but is not limited to starch, carboxymethyl starch sodium, sodium bicarbonate and Citric acid, tartaric acid or low-substituted hydroxypropyl cellulose etc..Described stabilizer includes but is not limited to polysaccharide such as agar, acrylic acid tree Fat, cellulose ether and carboxymethyl cellulose etc..Described solvent includes water, phosphate buffer, Mannitol, the saline solution of balance Etc..
Semen Cuscutae: this product is the dry mature seed of convolvulus cuscuta plant cuscuta chinensis lam..Autumn Harvest plant during season fruit maturation, dry, lay seed, remove impurity.[nature and flavor] are sweet, temperature.[return through] Return liver, kidney, spleen channel. [indication] nourishing the liver and kidney, astringent sperm contracting urine, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, waist Knees soreness, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen kidney deficiency is rushed down；Externally treating leucoderma.Semen Cuscutae be flat the kidney invigorating simply, liver, The good medicine of spleen, clinic is mainly used in lumbago due to renal deficiency, impotence and seminal emission, frequent micturition, uterus cold infertile, the kidney yin yang deficiency syndrome of the dark loose stool of mesh. Semen Cuscutae is sweet, warm, returns kidney,liver,spleen warp, has the effect of nourishing the liver and kidney, astringent sperm contracting urine, antiabortive, improving eyesight, antidiarrheal, begins to carry " the legendary god of farming Herbal warp ", it is listed in top grade.Sugariness typically has tonic effect, sweet pungent tepor, report gas neutralization, both can YANG invigorating, again can tonifying YIN, There is temperature and not dry, mend and not stagnant feature.Controlling nocturnal emission with astringent drugs is antiabortive and gonadotropic Effect.The traditional Chinese medical science thinks that the kidney being the origin of congenital constitution, interior residence Kidney-Yin and Yuanyang, are the roots of human body reproductive development, the motive power of internal organs functional activity.
Poria: meridian distribution of property and flavor: sweet；Light；Flat.The heart；Spleen；Lung；Kidney channel.Eliminating dampness and diuresises；Invigorating the spleen and regulating the stomach；Mind tranquilizing and the heart calming.With In dysuria；Oedema turgor；Phlegm retention cough with dyspnea；Vomiting；Spleen eating less；Have loose bowels；Palpitation and restlessness；Insomnia forgetfulness；Seminal emission nebulousurine.With In diarrhea due to hypofunction of the spleen, Poria can spleen invigorating, and can eliminating dampness by diuresis, have loose bowels for caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has The effect of giving consideration to both the incidental and fundamental, Poria is often and the compatibility such as Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Poria can be used as tonifying the lung spleen again, controls assisting a ruler in governing a country of the deficiency of vital energy Medicine.For cardiopalmus, the disease Poria energy tranquilizing by nourishing the heart such as insomnia, therefore can be used for the diseases such as irritability, cardiopalmus, insomnia, Poria often with The compatibilities such as Radix Ginseng, Radix Polygalae, Semen Ziziphi Spinosae.For cough due to fluid-retention, phlegm-damp enters network, aching pain in shoulder and back Poria can promoting diuresis to eliminate damp pathogen, have strong again Spleen acts on, and is unable to transmitting and distributing the fluids for insufficiency of the spleen, stops the disease of the raw phlegm retention of dimerization, has therapeutical effect.
Fructus Schisandrae Chinensis: acid, temperature.Enter lung, kidney channel, astringe the lung, nourishing kidney, promote the production of body fluid, receive antiperspirant, arresting seminal emission.Control the deficiency of the lung to breath with cough, xerostomia is made yearningly, Spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, protracted dysentery and diarrhea.
Caulis Polygoni Multiflori: sweet in the mouth, mild-natured, GUIXIN, Liver Channel, there is nourishing blood to tranquillize the mind, effect of dispelling wind and removing obstruction in the collateral, cure mainly insomnia and dreamful sleep, Blood deficiency general pain, rheumatic arthralgia；Skin pruritus etc. are demonstrate,proved.Ramulus et Folium Bauhiniae Faberi: latin name euphorbiae hirate herba, mildly bitter flavor, micro- Acid, cool in nature, there is heat-clearing and toxic substances removing, effect of removing dampness through diuresis and relieving itching, for bacillary dysentery, amebic dysentery, enteritis, intestinal infusorian, Dyspepsia, bronchitis, pyelonephritis；The card such as eczema, dermatitis, skin pruritus is controlled in external.
Radix Puerariae, Chinese medicine name.For the dry root of legume pueraria lobata, practise and claim Herba Gelsemii Elegantis.It is dried.Sweet, pungent, cool.There is expelling pathogenic factors from muscles for reducing heat, Rash, promoting the production of body fluid to quench thirst, the work(of Shengyang Zhixie.Mainly have relieve the effect of alcohol, lipid-loweringing, blood pressure lowering, pathogenic fire reducing, heat-clearing and toxic substances removing, yang invigorating expelling pathogenic factors from muscles, spasmolytic town Bitterly, rash antidiarrheal, increase brain and crown blood glucose, the effects such as improve brain microcirculation, be to prevent and treat hypertension, hyperlipidemia, coronary heart disease, the heart The important source material of the medicine of multiple disease such as angor, diabetes, cerebral thrombosiss, gastroenteropathy, has to women cosmetology and health etc. simultaneously Special efficacy.
Rhizoma Polygonati Odorati also known as Tibetan thick soup, Caulis Clematidis apiifoliae, are the dry rhizome of liliaceous plant Rhizoma Polygonati Odorati.Rhizoma Polygonati Odorati cold nature, sweet in the mouth is put down, return lung, Stomach, has nourishing YIN to relieve dryness, the work(of promoting the production of body fluid to quench thirst.Polysaccharide, steroidal saponin, flavone, alkaloid, cardiac glycoside etc. is contained many in Rhizoma Polygonati Odorati Kind of composition, wherein content highest fragrant solomonseal rhizome polyoses, as one of effective medicinal ingredient of Rhizoma Polygonati Odorati, fragrant solomonseal rhizome polyoses have immunity tune The pharmacology such as section, blood sugar lowering, defying age, Adjust-blood lipid and anti peroxidation of lipid, enhancing mice hypoxia-bearing capability, antitumor action is lived Property.
Hubei Chinese flowering crabapple contain tea polyphenols, flavone, after albumen and the several mineral materials such as fe, cu, zn, mn, have anti-inflammation, Anoxia enduring, resisting fatigue, blood sugar lowering etc. act on.
Rhizoma Polygonati, also known as: polygonatum sibiricum Redoute, yellow chicken dish, shaft of a writing brush dish, claw ginseng, Rhizoma Polygonati Cirrhifolii, JIZHUASHEN.For HUANGJING ZANYU CAPSULE, have There are spleen reinforcing, the effect of the lung moistening and production of body fluid promoting.Rhizoma Polygonati nature and flavor are sweet, eat tasty and refreshing.Its meat root stock is plump, containing much starch, sugar Point, fat, protein, carotene, vitamin and other nutritional labelings multiple, eat raw, stewed clothes can be allayed one's hunger, have again body-building it With strength multiplication can be made us, muscle fills, bone marrow is strong, highly beneficial to body.Modern study proves, Rhizoma Polygonati water extraction goes out liquid There is inhibitory action to Bacillus typhi, staphylococcus aureuses, acid-fast bacilli；Blood glucose that epinephrine is caused too high in significant suppression Make and use；There is stronger resisting fatigue, antioxidation and delaying senility function；It is significantly increased the effect of anesthetized dog coronary flow.
Bamboo vinegar is through pyrogenous natural valuable elite by bamboo wood, and it contains more than 200 kind of natural and organic ingredients and mineral Matter, has that antiphlogistic antibacterial, insect protected be fresh-keeping, a smelly eliminating beauty treatment and other effects.
The present invention has the beneficial effect that:
1st, the composition treatment effect that the present invention provides substantially, can blood sugar lowering, and body is had no toxic side effect, patient makes With rear, dependence feeling is not produced to medicine, and this Chinese medicine price is relatively low, be that ordinary people is acceptable；
2nd, the present invention carries out extraction process to raw material, and the composition finally concentrating carries out preparation process again, improves the work of preparation Property constituent concentration, improve drug effect；
3rd, it is directed to different raw materials, using different extracting modes, strive for that extraction efficiency maximizes, and to the thing after extracting Material carries out concentrating under reduced pressure, dried, keeps active component.
4th, by green section of grass, Caulis Polygoni Multiflori, Hubei Chinese flowering crabapple freezing processing, freezing can make rapidly cell damage to the present invention, one Determine the purpose of damaged cell in degree, and the relative damage ratio that improve cell, improve extraction ratio；And fumigated using steam, go Except bad taste, the extraction efficiency of functional components in green section of grass of raising, Caulis Polygoni Multiflori, Hubei Chinese flowering crabapple；
5th, the present invention adopt HIGH PRESSURE TREATMENT, under high pressure, its result be protein denaturation, starch gelatinization, enzyme inactivation, micro- Biological death, pressure seldom, and is reduced to 0 so that active substance is isolated by moment by nutrition loss, compares existing Technology, effect is good, and the time is short；
6th, material is carried out with emulsifying, the rotor of high speed dispersion emulsifying machine, in high-speed rotation, produces very big centrifugation Power makes processed material spray from the elongated cuts (slit) of rotation, and under the collective effect of stator, makes processed Material is subject to both sides active force: forces it through the positive force of slit and the resistance stoping it from passing through.Meanwhile, it is processed Material when spraying from slit, be also subject to the shear action of slit, and the rotation being produced by turning stator relative motion cut Shear force makes material obtain homogenizing, emulsifying in the presence of multi-acting force.It is narrow, all that the material processing has particle distribution range Evenness is good, no dead angle, the feature by dispersion and emulsion for the material 100%.
7th, the present invention passes through combination of ultrasound electric field treatment, and the harmful components such as the aldehyde in bamboo vinegar liquid are removed, by bamboo vinegar liquid plus Enter in tea, the effect of antibiotic and sterilizing sterilization can be played, the composition beneficial to human body can be retained simultaneously in tea.The present invention can Understand interior free yl rubbish, delay to enhance metabolism, heat clearing away blood sugar lowering, no added.
8th, cryogenic temperature ensure that the moisture in Rhizoma Polygonati Odorati, Rhizoma Polygonati is sufficiently formed ice pellets, is easy to the distillation of follow-up ice crystal, In addition, in the environment of this freezing, also effectively suppression microorganism grow it is ensured that sanitary condition.Can also effectively suppress beautiful simultaneously Bamboo, the activity of the enzyme of Rhizoma Polygonati, it is to avoid the oxidation of its nutrition and functional components and decomposition, the vacuum drying temperature after freezing Nutritional labeling can be prevented effectively from oxygen free condition to be destroyed, and can prevent the specific flavor components of Rhizoma Polygonati Odorati, Rhizoma Polygonati from being volatilized, I other words at a temperature of this vacuum drying, ice crystal can not only be enable effectively to distil moreover it is possible to be effectively kept Radix Glycyrrhizae, Rhizoma Polygonati Odorati, Specific flavor components in Rhizoma Polygonati.
9th, lyophilization makes Radix Puerariae be internally formed a large amount of cavities, is conducive to the infiltration of the compositions such as later stage extractant；In Radix Puerariae Dissolubility in ethanol water for the active component higher, adopt low temperature ultrasonic-microwave cooperating extractive technique simultaneously, extract temperature Degree is relatively low, the time is shorter, can be prevented effectively from Radix Puerariae active component in extraction process oxidized.
10th, resistant dextrin, sucralose are added in cold distilled water, resistant dextrin is a kind of Low Caloric Polydextrose, with sky The low molecule water soluble dietary fiber that so starch is prepared for raw material, with respect to other diet fiber products, resistant dextrin has good Acid well, heat stability, high digestion toleration, low-glycemic, low insulin index, heat is low, prevents dental caries etc. excellent Characteristic, the present invention passes through to add resistant dextrin to cold distilled water so that nutrient substance will not be destroyed in freeze-drying process, And hyperpyrexia quantity of material can be reduced.Resistant dextrin is gi (glycaemic index) value < 5, has the physiology that suppression blood glucose rises Effect, can effectively reduce the gi value of other products, thus effectively helping diabeticss to control glycaemic index.Sucralose is also Sweet taste can be adjusted it is adaptable to diabeticss use.
11st, the present composition, except having effect of lowering blood sugar, also utilizes the group of bamboo vinegar liquid, Radix Puerariae and other materials Close, significantly improve the effect of inhibiting bacteria and diminishing inflammation.
Specific embodiment
To further illustrate the present invention with reference to embodiment, but the scope of protection of present invention is not limited to implement The scope of example statement.
Embodiment 1
A kind of Chinese medicine composition with effect of lowering blood sugar, described compositionss include following raw material component:
10 parts of Semen Cuscutae, 5 parts of Poria, 4 parts of Semen Nelumbinis, 6 parts of Fructus Schisandrae Chinensis, 12 parts of Caulis Polygoni Multiflori, 8 parts of Hubei Chinese flowering crabapple, bamboo vinegar liquid 12 parts, 11 parts of Radix Puerariae, 7 parts of Rhizoma Polygonati Odorati, 6 parts of Rhizoma Polygonati, 2～3 parts of swellable material.
Described swellable material includes raw material components by weight: 0.5 part of hydroxypropyl methyl cellulose, carboxymethyl cellulose 0.1 part of plain sodium, 0.4 part of carrageenan.
The method making described Chinese medicine composition, the method comprising the steps of:
1) weigh raw material components, successively raw material is pulverized respectively with Chinese medicine grinder, each grinding time 7 minutes, Pulverized with super micron mill again after crossing 100 mesh sieves, standby；
2) by above-mentioned steps 1) pulverize after Semen Cuscutae, Poria, be stirred carrying with 85% ethanol of its 8 times of weight Take, after extraction, carry out solid-liquid separation, remove filtering residue concentrating under reduced pressure, drying, dried object is pulverized, obtains material 1；
3) by above-mentioned steps 1) pulverize after Semen Nelumbinis, Fructus Schisandrae Chinensis, with water heating and refluxing extraction 2-3 time of its 7 times of weight, conjunction And lixiviating solution, by gained lixiviating solution concentrating under reduced pressure, dry, pulverize, obtain material 2；
4) by above-mentioned steps 1) pulverize after Caulis Polygoni Multiflori, Hubei Chinese flowering crabapple add cold distilled water solution, then carry out ultralow temperature Lyophilization drying is less than 7% to moisture, obtains material 3；
5) material 1, material 2, material 3 are mixed, smash, add the water of mixture identical weight, put into and disperse at a high speed breast Change machine is processed, and obtains high speed dispersion and emulsion thing；
6) pressurised extraction: by step 5) process after emulsion, put in pressure pan, add emulsion identical weight Water, pressurization and then recovery normal pressure, filter, obtain extracting solution, and be condensed into extractum, and concentrating under reduced pressure, drying obtain extract；
7) Radix Puerariae is stacked 5 days at 15 DEG C, and lyophilizing is pulverized；Add the organic solvent of its 8 times of weight, carry out ultrasonic-microwave Collaborative extraction, the filtrate cryoconcentration being filtrated to get obtains concentrated solution, then is dried, and dried object is pulverized, obtains thing Material 4；
8) carry out lyophilization, pulverization process by after Rhizoma Polygonati Odorati, Rhizoma Polygonati section, obtain Rhizoma Polygonati Odorati powder, Rhizoma Polygonati powder；
9) by bamboo vinegar liquid with combination of ultrasound electric field treatment, and it is condensed into extractum, concentrating under reduced pressure, dry, pulverize, cross 85 mesh Sieve, obtains bamboo vinegar liquid extract；
10) by described step 6) extract that obtains, described step 7) material 4, step 8) Rhizoma Polygonati Odorati powder, Rhizoma Polygonati powder, step 9) mixing of bamboo vinegar liquid extract, tabletting, spray swellable material in schistose surface, obtain tablet；
Described swellable material adds 85 DEG C of pure water to spray after being configured to 2% solution.
Complete the making of compositionss.
Methods described also includes raw material green section of grass, Caulis Polygoni Multiflori, Hubei Chinese flowering crabapple and carries out efficacy of a drug fermentation pretreatment before pulverizing, its Processing method is: by green section of grass, Caulis Polygoni Multiflori, Hubei Chinese flowering crabapple freezing processing, then steam treatment, the dry efficacy of a drug that formed ferment green section Grass, Caulis Polygoni Multiflori, Hubei Chinese flowering crabapple carry out described step 1 again) pulverization process.
Described baking temperature is 70 DEG C, is dried to moisture below 6%.
Described step 4) also comprise the resistant dextrin, 16% sucralose that concentration is 15%, cold distillation in cold distilled water Coolant-temperature gage is 15 DEG C, -35 DEG C of lyophilization temperature.
Described step 7) organic solvent is the ethanol that volumetric concentration is 75%, the condition that ultrasonic-microwave cooperating extracts is: micro- Wave power 360w, ultrasonic power 450w, 16 DEG C of temperature, carry out ultrasonic-microwave cooperating and extract 1100s.
Described step 6) it is forced into 3.8kg/cm2, and keep 13min, in 2s, then recover normal pressure.
Described step 9) combination of ultrasound electric field treatment method is: first with frequency 50khz, supersound process 15min, then use intensity The Electric Pulse Treatment 9min of 8kv/cm.
The present invention is for blood sugar lowering clinical observation result:
1.1 physical data: select the People's Hospital of city outpatient service type 2 diabetes mellitus patient 60, be randomly divided into two groups.Treatment group 30 Example, man 16, female 14,30～70 years old age, average (50 ± 1.5) year, the course of disease 6 months～15 years, average (8.0 ± 1.2) Year；Matched group 30；Man 18；Female 12,29～70 years old age.Two groups of physical data comparing differences not statistically significant (p > 0.05), there is comparability.
1.2 case selections: with reference to World Health Organization's (who) diabetes diagnosis in 1999 and parting standard [1]: diabetes Symptom+random time plasma glucose levels >=11.1mmol/l (200mg/dl).The patient meeting above-mentioned standard is divided at random Group carries out observational study, and the patient partly taking traditional Chinese medicine stops former Chinese medicine and includes observation after 2 weeks, and the patient not taken traditional Chinese medicine is directly brought into sight Examine.Two groups of patients all give Diabetes Foundation to treat, and including diet control, exercise therapy and orally-taken blood sugar reducing Western medicine, blood sugar lowering Western medicine is adopted With metformin, drug usage and dose adjustment are carried out according to blood glucose situation.
1.3 Therapeutic Method: treatment group takes Chinese medicinal tablet of the present invention on the basis of taking metformin.Daily in three times Take, 5 grams every time.Matched group routine takes metformin.Two groups are consistent in diet control, exercise therapy, two groups of treatments Cheng Junwei 2 months.
1.4 observation index: measure fasting glucose (fpg), post-prandial glycemia (2hbg), glycolated hemoglobin before and after treatment respectively (hba1c), fasting insulin (fins), blood glucose determination of glucose oxidase, insulin is measured with putting method of exempting from, and blood fat is with entirely Automatic biochemistry analyzer measures, and homa-ir adopts haffner etc. to calculate the formula of ir, i.e. homa-ir=in homa model Fpg × fins/22.5 (fpg unit is mmol/l, and fins unit is mu/l).
1.5 statistical methods: statistical procedures are carried out using spss 14.0 statistical analysis software.Measurement data adopts t to examine Test, enumeration data chi-square criterion.
2 results: before and after two groups of treatments, the change of fpg, 2hbg, hbaic, fins and homa-ir refers to table 1.By in table 1 I Can see, treatment the horizontal comparing difference of front two groups of patients fpg, 2hbg, hbalc, fins, homa-ir not statistically significant (p>0.05)；Before two groups of fpg, 2hbg, hbalc, fins, homa-ir levels and treatment after treatment, comparing difference has statistics to anticipate Adopted (p < 0.05 or p < 0.01), treatment group's patient's These parameters have significant difference (p < 0.01) with comparing before treatment.Treatment group All diabetes glucose can be reduced with matched group, but blood glucose be improved with treatment group and becomes apparent from.
The change of fpg, 2hbg, hbalc, fins and homa-ir before and after 1 liang of group patient's treatment of table
Note: indices compared with pre-treatment: * p < 0.05, * * p < 0.01；After treatment, two groups of fins and homa-ir compare ^ P < 0.05, ^^p < 0.01.
Case introduces 1:
Zhang, man, 57 years old, private storekeeper, diabetes medical history has 8 years.In early days, symptom is lighter, and empty stomach whole blood blood glucose is 6.8 MM/l, more steadily, but nearest 3 years, disease is more serious, and empty stomach whole blood blood glucose reaches 9.7 mM/ls, and companion There is dehydrating phenomena.Many-side is sought medical advice for many years, more can only slowly control ongoing disease, but not preferably by the effect of blood glucose Really.Take two courses for the treatment of of preparation of the present invention, blood pressure is substantially reduced, and empty stomach whole blood blood glucose will be 6.6 mM/ls, not Dehydrating phenomena.Continue to take this preparation, 2 months afterwards blood glucose will be normal level.This preparation obtains obvious blood sugar decreasing effect.
Case introduces 2:
Wang, man, 50 years old, retirement was in, and the hyperglycemia time has 4 years, and symptom is lighter, and empty stomach whole blood blood glucose is 6.7 mmoles You/liter.More significantly symptom is many for getting up in the night to urinate, and gets up in the night to urinate 2-4 time every night.Phenomenon of getting up in the night to urinate after taking two courses for the treatment of of invention formulation obtains To improving, empty stomach whole blood blood glucose drops to 5.9 mM/ls.The blood sugar decreasing effect of this preparation substantially, and has no side effect.
Case introduces 3:
Guo, female, 62 years old, civil servant, diabetic history had 16 years.Its empty stomach whole blood blood sugar concentration is in 13.0 mmoles You/liter about, and with frequent micturition, the manifest symptom such as dehydration, thirsty, Nausea and vomiting, is more serious case.Take this system After two courses for the treatment of of agent, empty stomach whole blood blood glucose drops to less than 9 mM/ls, Nausea and vomiting symptom mitigation, continues to take 5 treatments After journey, empty stomach whole blood glycemic control is at 7.3 mM/ls about, and frequent micturition, thirsty phenomenon also substantially mitigate, and do not have it The sensation of his discomfort.Substantially, investigation is taking this preparation before terminating to curative effect always.
Case introduces 4:
Wu, man, 51 years old, suffers from diabetes 8 years, 9.3 mM/ls of empty stomach whole blood blood glucose.Separately check its blood pressure, diastolic pressure 92nd, systolic pressure 155, with hypertension symptom.After taking other hypoglycemic medicines, blood glucose is reduced, but it is very big to rise and fall, Unstable, during whole blood blood sugar concentration higher in normal value, when and reach 9.1 mM/ls of maximum, after drug withdrawal always It is high state.After taking 3 courses for the treatment of of this preparation, glycemic control, at 5.8 mM/ls, has substantially hypoglycemic Effect, and, the phenomenon of its hypertension also improved, diastolic pressure 85, systolic pressure 137, and no other side effect.
Case introduces 5:
Easily certain, man, 49 years old, have no property, because of long-term excessive drinking simultaneously obesity, lead to hyperglycemia, before 4 years, checked that its blood glucose is inclined Height, its empty stomach whole blood blood glucose typically at 8.8 mM/ls about hence it is evident that complication be frequent micturition, xerosis cutiss, control drink simultaneously After moderate exercise, its blood glucose drops to 8.3 mM/ls, but does not drop to normal value, and has phenomenon repeatedly, is to be dropped Take this Chinese medicine preparation to normal value.After two courses for the treatment of, empty stomach whole blood blood glucose drops to 6.9 mM/ls, is further continued for taking two Drop to 6.1 mM/ls after the individual course for the treatment of, and obtain controlling hypourocrinia, xerosis cutiss symptom mitigates, not anti-after off-drug Bullet, does not have other senses of discomfort yet.Said preparation curative effect is obvious.
It is seen that the present invention has the beneficial effects that, the present invention makes theoretical foundation in conjunction with above clinical data and the present invention Preparation, blood sugar decreasing effect is substantially, and nontoxic, has no side effect, effect stability, and reparation technology is simple and easy to do.
Embodiment 2
A kind of Chinese medicine composition with effect of lowering blood sugar, described compositionss include following raw material component:
15 parts of Semen Cuscutae, 5 parts of Poria, 5 parts of Semen Nelumbinis, 6 parts of Fructus Schisandrae Chinensis, 12 parts of Caulis Polygoni Multiflori, 7 parts of Hubei Chinese flowering crabapple, bamboo vinegar liquid 12 parts, 12 parts of Radix Puerariae, 11 parts of Rhizoma Polygonati Odorati, 6 parts of Rhizoma Polygonati, 2.5 parts of swellable material.
Described swellable material includes raw material components by weight: 0.5 part of hydroxypropyl methyl cellulose, carboxymethyl cellulose 0.1 part of plain sodium, 0.4 part of carrageenan.
The method making described Chinese medicine composition, the method comprising the steps of:
1) weigh raw material components, successively raw material is pulverized respectively with Chinese medicine grinder, each grinding time 2-10 divides Clock, is pulverized with super micron mill after crossing 100 mesh sieves again, standby；
2) by above-mentioned steps 1) pulverize after Semen Cuscutae, Poria, be stirred carrying with 85% ethanol of its 7 times of weight Take, after extraction, carry out solid-liquid separation, remove filtering residue concentrating under reduced pressure, drying, dried object is pulverized, obtains material 1；
3) by above-mentioned steps 1) pulverize after Semen Nelumbinis, Fructus Schisandrae Chinensis, with the water heating and refluxing extraction 3 times of its 9 times of weight, merge Lixiviating solution, by gained lixiviating solution concentrating under reduced pressure, dry, pulverize, obtains material 2；
4) by above-mentioned steps 1) pulverize after Caulis Polygoni Multiflori, Hubei Chinese flowering crabapple add cold distilled water solution, then carry out ultralow temperature Lyophilization drying is less than 7% to moisture, obtains material 3；
5) material 1, material 2, material 3 are mixed, smash, add the water of mixture identical weight, put into and disperse at a high speed breast Change machine is processed, and obtains high speed dispersion and emulsion thing；
6) pressurised extraction: by step 5) process after emulsion, put in pressure pan, add emulsion identical weight Water, pressurization and then recovery normal pressure, filter, obtain extracting solution, and be condensed into extractum, and concentrating under reduced pressure, drying obtain extract；
7) Radix Puerariae is stacked 3 days at 18 DEG C, and lyophilizing is pulverized；Add the organic solvent of its 8 times of weight, carry out ultrasonic-microwave Collaborative extraction, the filtrate cryoconcentration being filtrated to get obtains concentrated solution, then is dried, and dried object is pulverized, obtains thing Material 4；
8) carry out lyophilization, pulverization process by after Rhizoma Polygonati Odorati, Rhizoma Polygonati section, obtain Rhizoma Polygonati Odorati powder, Rhizoma Polygonati powder；
9) by bamboo vinegar liquid with combination of ultrasound electric field treatment, and it is condensed into extractum, concentrating under reduced pressure, dry, pulverize, cross 85 mesh Sieve, obtains bamboo vinegar liquid extract；
10) by described step 6) extract that obtains, described step 7) material 4, step 8) Rhizoma Polygonati Odorati powder, Rhizoma Polygonati powder, step 9) mixing of bamboo vinegar liquid extract, tabletting, spray swellable material in schistose surface, obtain tablet；
Described swellable material adds 85 DEG C of pure water to spray after being configured to 2% solution.
Complete the making of compositionss.
Methods described also includes raw material green section of grass, Caulis Polygoni Multiflori, Hubei Chinese flowering crabapple and carries out efficacy of a drug fermentation pretreatment before pulverizing, its Processing method is: by green section of grass, Caulis Polygoni Multiflori, Hubei Chinese flowering crabapple freezing processing, then steam treatment, the dry efficacy of a drug that formed ferment green section Grass, Caulis Polygoni Multiflori, Hubei Chinese flowering crabapple carry out described step 1 again) pulverization process.
Described baking temperature is 55 DEG C, is dried to moisture below 6%.
Described step 4) also comprise the resistant dextrin, 16% sucralose that concentration is 15%, cold distillation in cold distilled water Coolant-temperature gage is 15 DEG C, -25 DEG C of lyophilization temperature.
Described step 7) organic solvent is the ethanol that volumetric concentration is 75%, the condition that ultrasonic-microwave cooperating extracts is: micro- Wave power 360w, ultrasonic power 450w, 30 DEG C of temperature, carry out ultrasonic-microwave cooperating and extract 1200s.
Described step 6) it is forced into 3.9kg/cm2, and keep 13min, in 2s, then recover normal pressure.Preferably, described Step 9) combination of ultrasound electric field treatment method is: first with frequency 50khz, supersound process 15min, the more electric arteries and veins with intensity 8kv/cm Punching processes 8min.
The clinical observation result of present invention treatment conjunctivitis:
The traditional Chinese medical science thinks that keratoconjunctivitiss are subject to ailment said due to cold or exposure outside being, above attacks in mesh, pathogen contact is popular between eyelid corner of the eyes space between skin and muscles, therefore causes mesh Itch.In the present invention, sack made by leather perfume heat-clearing and toxic substances removing, is monarch drug, Fici hispidae dispelling wind is antipyretic, scattered stasis, and Chinese clematis leaf removing toxic substances, promoting blood circulation disappear Swollen, it is ministerial drug, Radix Cynanchi Paniculati warming middle-JIAO to relieve pain, killing parasites for relieving itching, promoting blood circulation and detoxication, Flos Lonicerae heat-clearing and toxic substances removing, dispelling wind and heat pathogens, attached column spends heat clearing away Removing toxic substances, removing dampness through diuresis and relieving itching, green section of careless removing toxic substances and promoting subsidence of swelling, Herba Senecionis Scandentiss heat-clearing and toxic substances removing, improving acuity of vision and removing nebula, antipruritic, Periostracum Cicadae dispelling wind and heat pathogens, rash is stopped Itch, Fructus Xanthii powder wind and cold, antipruritic.Find that through clinical practice there is to keratoconjunctivitiss the curative effect of uniqueness, reach treatment angle conjunctiva Scorching purpose.
, in 71 patients of 2012 to 2014 clinical observation keratoconjunctivitiss, clinical report is as follows for Chinese medicine of the present invention:
1st, physical data
In 81 patients, age 18-65 year, the course of disease many at 1 week to 3 months, 36 years old mean age.
2nd, diagnostic criteria
2.1 carry out clinical diagnosises with reference to the diagnosis basis in " Chinese medical disease Standardization of diagnosis and curative effect ":
Upper tarsal conjunctiva nipple hypertrophy is in flat paving stone sample, or cornea edge glue sample tuberosity；More in conjunctival secretion Eosinophilic granulocyte and the eosinophilic granulocyte's tuberosity being dispersed in.
3rd, Therapeutic Method
Tablets, daily 9,3 times a day, is within 7 days 1 course for the treatment of.
4th, therapeutic outcome:
4.1 treatment evaluation criterias, judge according to " Chinese medical disease Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine formulates:
Cure: clinical symptoms and sign all disappear, vision restoration is normal (or vision restoration is to premorbid vision)；
Effective: vision improves, clinical symptoms and sign all disappear；
Effective: clinical symptoms and sign all disappear or partial disappearance or improvement, and vision no improves；
Invalid: vision no improves or clinical symptoms and sign no take a turn for the better or increase.
4.2 results: in 81 patients, 56 (52.1%) of healing, effective 14 (25.4%), effective 10 (21.1%), invalid 1 (1.4%) example, total effective rate is 98.8%.
Model case
1st, Wang, man, 29 years old, right eye was very itched, and recurrent exerbation is more than the moon.Red tongue, stringy pulse is slightly several.Check: hyperemia of the bulbar conjunctiva is black Eyeball central authorities and periphery have the punctate opacity of the cornea of several Semen Sesami sizes.Vision: right eye 0.12, left eye 1.2, examine as keratoconjunctivitiss.2 after medication After the individual course for the treatment of, above-mentioned symptom mitigates, and eye is itched and gone down, and checks that right vision is promoted to 0.8.Continue to take medicine of the present invention, 1 After the course for the treatment of, symptom disappears, and follow-up after a year is no recurred.
2nd, week certain, female, 26 years old, eyes were very itched, now with headache, heating.Check: binocular vision is 1.0, and Dual-eyelid is light Degree swelling, palpebral conjunctiva is congested substantially, and lower eyelid fornix portion has folliculus to be formed, and cornea of left eye has point-like inflammatory infiltration, red tongue.Take 1 course for the treatment of of medicine of the present invention, daily 1 dose, symptom disappears, and follow-up after a year is no recurred.
3rd, week certain, patient's readme, it once suffers from " pink eye disease " classmate's close contact with part, and originally two have foreign body sensation, Itch, photophobia, shed tears, then eye conjunctiva is more and more redder, gum gets more and more.It is diagnosed as conjunctivitis on inspection.Controlled using the present invention Treat, fully recover after 3 days.Its father and mother also daily present invention 1 time, 1 ball every time, serve on three days.Follow-up after January, Wang is no recurred, Its father and mother has no infection.
In vitro Bactericidal Experiments
Trial drug: the Chinese medicine in the present embodiment.
Method: using micro continuous doubling dilution measure the present embodiment Chinese medicine to escherichia coli, staphylococcus aureuses, Pseudomonas aeruginosas, staphylococcus epidermidiss, proteus vulgaris, the mark bacterial strain of streptococcus faecalis and escherichia coli, golden yellow Portugal Grape coccus, Pseudomonas aeruginosas, staphylococcus epidermidiss, proteus vulgaris, streptococcus faecalis clinical separation strain minimum antibacterial dense Degree (mic), measures the minimal bactericidal concentration (mbc) to above-mentioned antibacterial for the Chinese medicine in the present embodiment using flat board infection protocol.Will be big Enterobacteria, staphylococcus aureuses, Pseudomonas aeruginosas, staphylococcus epidermidiss, proteus vulgaris, it is inoculated in mh meat soup, put 37 DEG C of culture 24h of standard incubator；Streptococcus faecalis are inoculated in tpy meat soup (anaerobe nutrient broth), put 37 DEG C of anaerobic culture box Culture 48h.
The least concentration that bacterial growth in culture medium can be suppressed is minimal inhibitory concentration (minimal inhibitory Concentration, mic).During killing antibacterial for evaluation criteria, total viable count is made to reduce 99% or more than 99.5%, referred to as Minimal bactericidal concentration (minimal bactericidal concentration, mbc).A collection of experiment in can suppress 50% or Mic needed for 90% tested bacterium, is referred to as mic50And mic90.The bacteriostasis of antimicrobial drug are relative with bactericidal action, and some resist Bacterium medicine is in bacteriostasis in low concentration, and high concentration is in bactericidal action.
Mic and mbc to reference culture for the table 2 the present embodiment pharmaceutical composition
Bacterial strain Mic (mg compositionss/ml) Mbc (mg compositionss/ml)
Escherichia coli atcc25922 strain 11.7 23.4
Staphylococcus aureuses atcc25922 strain 0.42 0.94
Pseudomonas aeruginosas atcc25922 strain 55 109
Staphylococcus epidermidiss atcc25922 strain 0.48 0.97
49010 plants of proteus vulgaris 29 64
32221 plants of streptococcus faecalis 0.43 1.70
From upper table 2, the present embodiment pharmaceutical composition to the selected escherichia coli of test, staphylococcus aureuses, Pseudomonas aeruginosas, staphylococcus epidermidiss, proteus vulgaris, streptococcus faecalis are clinically separated Reference Strains all obvious suppression And deactivation, its mbc is 2～4 times of mic.
Table 3 is the present embodiment pharmaceutical composition mic, mic to 265 plants of Clinical isolation50、mic99With mbc (mg group Compound/ml)
Mic and mbc to reference culture for the table 3 the present embodiment pharmaceutical composition
Bacterial strain Strain number mic mic50 mic99 mbc
Staphylococcus aureuses 100 0.40～1.47 1.032 1.31 0.75～6.31
Escherichia coli 110 6.39～48 17.861 22.146 30～800
Staphylococcus epidermidiss 30 0.35～3.12 0.712 1.4808 1.58～6.36
Proteus vulgaris 25 11.4～49 25.454 33.0531 35～88
From upper table 3, the present embodiment pharmaceutical composition 265 plant Clinical isolation selected to test all have necessarily Suppression and deactivation, its mbc is 2～4 times of mic.
When removing bamboo vinegar liquid or Radix Puerariae in Chinese medicinal components in the present embodiment, it is compared with the present embodiment fungistatic effect, survey Fixed inhibitory action mic (mg compositionss/ml) to bacterial strain.Comparing result is shown in Table 4.
Specifically comparative example is,
Comparative example 1: a kind of Chinese medicine composition with effect of lowering blood sugar, described compositionss include following parts by weight of component:
15 parts of Semen Cuscutae, 5 parts of Poria, 5 parts of Semen Nelumbinis, 6 parts of Fructus Schisandrae Chinensis, 12 parts of Caulis Polygoni Multiflori, 7 parts of Hubei Chinese flowering crabapple, Radix Puerariae 12 Part, 11 parts of Rhizoma Polygonati Odorati, 6 parts of Rhizoma Polygonati, 2.5 parts of swellable material.
Comparative example 2: a kind of Chinese medicine composition with effect of lowering blood sugar, described compositionss include following parts by weight of component:
15 parts of Semen Cuscutae, 5 parts of Poria, 5 parts of Semen Nelumbinis, 6 parts of Fructus Schisandrae Chinensis, 12 parts of Caulis Polygoni Multiflori, 7 parts of Hubei Chinese flowering crabapple, bamboo vinegar liquid 12 parts, 11 parts of Rhizoma Polygonati Odorati, 6 parts of Rhizoma Polygonati, 2.5 parts of swellable material.
Comparative example 3: a kind of Chinese medicine composition with effect of lowering blood sugar, described compositionss include following parts by weight of component:
15 parts of Semen Cuscutae, 5 parts of Poria, 5 parts of Semen Nelumbinis, 6 parts of Fructus Schisandrae Chinensis, 12 parts of Caulis Polygoni Multiflori, 7 parts of Hubei Chinese flowering crabapple, Rhizoma Polygonati Odorati 11 Part, 6 parts of Rhizoma Polygonati, 2.5 parts of swellable material.
Contrast on effect to the mic of reference culture in table 4 the present embodiment component
Bacterial strain Embodiment 10 Comparative example 1 Comparative example 2 Comparative example 3
Escherichia coli atcc25922 strain 11.7 12.5 14.5 29
Staphylococcus aureuses atcc25922 strain 0.42 0.51 0.63 63
Pseudomonas aeruginosas atcc25922 strain 55 58 78 135
Staphylococcus epidermidiss atcc25922 strain 0.48 0.52 8.35 There is no inhibition
49010 plants of proteus vulgaris 29 31 34 There is no inhibition
32221 plants of streptococcus faecalis 0.43 0.48 0.89 There is no inhibition
As shown in Table 4, for having fungistatic effect, both are used cooperatively with other components for the Radix Puerariae in prescription, bamboo vinegar liquid, Effect is optimum.
The above embodiments are only the preferred technical solution of the present invention, and are not construed as the restriction for the present invention, this Shen Please in embodiment and the feature in embodiment in the case of not conflicting, can mutual combination in any.The protection model of the present invention Enclose the technical scheme that should record with claim, the equivalent side of technical characteristic in the technical scheme recorded including claim Case is protection domain.I.e. equivalent within this range is improved, also within protection scope of the present invention.

Claims (8)

1. a kind of Chinese medicine composition with effect of lowering blood sugar is it is characterised in that described compositionss include following raw material Component:
10～20 parts of Semen Cuscutae, 3～6 parts of Poria, 3～6 parts of Semen Nelumbinis, 5～7 parts of Fructus Schisandrae Chinensis.
2. according to claim 1 Chinese medicine composition it is characterised in that described compositionss also include following raw material group Point:
10～15 parts of Caulis Polygoni Multiflori, 3～10 parts of Hubei Chinese flowering crabapple, 8～13 parts of bamboo vinegar liquid.
3. according to claim 2 Chinese medicine composition it is characterised in that described compositionss also include following raw material group Point:
5～15 parts of Radix Puerariae, 3～12 parts of Rhizoma Polygonati Odorati, 5～7 parts of Rhizoma Polygonati.
4. make claim 3 described in Chinese medicine composition method it is characterised in that: the method comprising the steps of:
1) weigh raw material components, successively raw material is pulverized respectively with Chinese medicine grinder, each grinding time 2-10 minute, mistake Pulverized with super micron mill again after 100 mesh sieves, standby；
2) by above-mentioned steps 1) pulverize after Semen Cuscutae, Poria, stirred with 80%～95% ethanol of its 5-10 times of weight Mix extraction, after extraction, carry out solid-liquid separation, remove filtering residue concentrating under reduced pressure, drying, dried object is pulverized, obtains material 1；
3) by above-mentioned steps 1) pulverize after Semen Nelumbinis, Fructus Schisandrae Chinensis, with water heating and refluxing extraction 2-3 time of its 5-10 times of weight, conjunction And lixiviating solution, by gained lixiviating solution concentrating under reduced pressure, dry, pulverize, obtain material 2；
4) by above-mentioned steps 1) pulverize after Caulis Polygoni Multiflori, Hubei Chinese flowering crabapple add cold distilled water solution, then carry out cryotherapy It is dried and is less than 7% to moisture, obtain material 3；
5) material 1, material 2, material 3 are mixed, smash, add the water of mixture identical weight, put into high speed dispersion emulsifying machine Process, obtain high speed dispersion and emulsion thing；
6) pressurised extraction: by step 5) process after emulsion, put in pressure pan, add emulsion identical weight water, plus Pressure and then recovery normal pressure, filter, obtain extracting solution, and be condensed into extractum, and concentrating under reduced pressure, drying obtain extract；
7) Radix Puerariae is stacked 2-6 days at 10～20 DEG C, and lyophilizing is pulverized；Add the organic solvent of its 5～10 times of weight, surpassed Sound-microwave cooperating extracts, and the filtrate cryoconcentration being filtrated to get obtains concentrated solution, then is dried, and dried object is pulverized, Obtain material 4；
8) carry out lyophilization, pulverization process by after Rhizoma Polygonati Odorati, Rhizoma Polygonati section, obtain Rhizoma Polygonati Odorati powder, Rhizoma Polygonati powder；
9) by bamboo vinegar liquid with combination of ultrasound electric field treatment, and it is condensed into extractum, concentrating under reduced pressure, dry, pulverize, cross 80～90 mesh Sieve, obtains bamboo vinegar liquid extract；
10) by described step 6) extract that obtains, described step 7) material 4, step 8) Rhizoma Polygonati Odorati powder, Rhizoma Polygonati powder, step 9) bamboo The mixing of jealous woman liquid extract, tabletting；
Complete the making of compositionss.
5. method according to claim 4 it is characterised in that: methods described also includes raw material green section of grass, Caulis Polygoni Multiflori, Hubei Caulis et folium euphorbiae milii carries out efficacy of a drug fermentation pretreatment before pulverizing, and its processing method is: by Caulis Polygoni Multiflori, Hubei Chinese flowering crabapple freezing processing, then steam Process, formation efficacy of a drug fermentation Caulis Polygoni Multiflori be dried, Hubei Chinese flowering crabapple carries out described step 1 again) pulverization process.
6. method according to claim 4 it is characterised in that: described baking temperature be 50-60 DEG C, be dried to moisture Less than 6%.
7. method according to claim 3 it is characterised in that: described step 6) be forced into 3.5～4kg/cm2, and keep 10-15min, then recovers normal pressure in 1-3s.
8. method according to claim 4 it is characterised in that: described step 9) combination of ultrasound electric field treatment method is: first With frequency 40～60khz, supersound process 5～20min, then the Electric Pulse Treatment 5～10min with intensity 5～10kv/cm.
CN201610880284.7A 2016-10-08 2016-10-08 Traditional Chinese medicinal composition with blood glucose reducing effect and manufacturing method thereof Pending CN106344655A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106720829A (en) * 2016-11-30 2017-05-31 高振达 A kind of polygonatum Solomon's seal sugar-tablet and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106720829A (en) * 2016-11-30 2017-05-31 高振达 A kind of polygonatum Solomon's seal sugar-tablet and preparation method thereof

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Application publication date: 20170125