CN104758369A - Traditional Chinese medicine combination and preparing method and application thereof - Google Patents
Traditional Chinese medicine combination and preparing method and application thereof Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine combination and a preparing method and application thereof. The traditional Chinese medicine combination is mainly prepared from, by weight, 2-15 parts of liquorice, 5-20 parts of honeysuckle, 20-120 parts of plantain herbs and 10-35 parts of lycopodium clavatum. According to the traditional Chinese medicine combination, synergistic coordination among the liquorice, the honeysuckle, the plantain herbs and the lycopodium clavatum is enhanced, and the traditional Chinese medicine combination can diminish inflammation and relieve pain, has an excellent uricosuric effect, increases the discharge rate, reduces uric acid, is remarkable in treatment effect and has the effects of reducing blood pressure, clearing the liver, improving vision, slightly losing weight, expelling phlegm to arrest coughing and the like. The preparing method of the traditional Chinese medicine combination is implemented in a water decocting mode and easy to implement, the content of effective active ingredients in an obtained extractor is high, in the decocting process, all the effective active ingredients interact and are effectively fused at high temperature, and therefore the traditional Chinese medicine combination has a better treatment effect.
Description
Technical field
The present invention relates to the field of Chinese medicines, in particular to a kind of Chinese medicine composition and its preparation method and application.
Background technology
Gout, also known as " hyperuricemia ", is a kind of because of disorders of purine metabolism, uric acid is accumulated and the disease that causes, belongs to arthritic one, also known as metabolic arthritis.The definition of gout has a kind of metabolism being called the material of purine to there occurs disorder in human body, the synthesis of uric acid (oxidation metabolites of purine) increases or discharges and reduces, cause hyperuricemia, when serum Uric Acid Concentration is too high, namely uric acid is deposited in joint, soft tissue, cartilage and kidney with the form of sodium salt, cause the foreign body inflammatory reaction of tissue, be just gout.
The medicine of more existing treatment gouts or mode mainly Western medicine or transfusion etc., Western medicine therapy adopts the mode such as anti-inflammatory analgetic, mandatory down uric acid to carry out symptom management mostly, in addition, also some treatment by Chinese herbs modes are had, but the crude drug that the recipe of a lot for the treatment of by Chinese herbs adds is many, treatment cycle is long, and can not effect a radical cure, as application number be 201210416621.9 application discloses a kind of medicine for the treatment of gout and preparation method thereof, it is mainly by Olibanum, Radix Glycyrrhizae, Fructus Chaenomelis, Radix Aconiti Lateralis Preparata, Herba Ephedrae, Fructus Forsythiae, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis, the Rhizoma Anemarrhenae, Fructus Gardeniae, the Radix Paeoniae Alba, Rhizoma Alismatis, Radix Sophorae Flavescentis, the first-class 15 kinds of medicines of Radix Aconiti are prepared from according to a certain weight ratio, the crude drug needed is very many, and its effect reached is all take a turn for the better or have no side effect.
There is following shortcoming in existing treatment gout medicine:
1., side effect is large, there will be the symptoms such as diarrhoea, vomiting after a lot of people of such as colchicine takes;
2., therapeutic effect is thorough, easily occurs recurrence, no matter is in therapeutic process or after treatment terminates;
3., the raw material type that adds is too many, and cause the zest taste of medicine too large, patient's long-term taking, causes appetite to weaken.
In view of this, special proposition the present invention.
Summary of the invention
The first object of the present invention is to provide a kind of Chinese medicine composition, and described Chinese medicine composition has no side effect, and therapeutic effect is remarkable, low cost.
The second object of the present invention is the preparation method providing a kind of described Chinese medicine composition, and the method is easy and simple to handle, and obtained medicinal liquid effective active composition is high, and therapeutic effect is good.
The third object of the present invention is to provide the application of described Chinese medicine composition.This Chinese medicine composition has the effect of antiinflammatory, pain relieving and uric acid resisting, mainly by releasing uric acid, repairs metabolism, gets rid of uric acid road calculus, and finally reach radical cure gout; In addition, also there is blood pressure lowering, liver heat removing and eyesight improving, long-term drink have the effects such as fat-reducing, and side effect is very little.
In order to realize above-mentioned purpose of the present invention, spy by the following technical solutions:
A kind of Chinese medicine composition, makes primarily of following raw material, by weight, and Radix Glycyrrhizae 2-15 part, Flos Lonicerae 5-20 part, Herba Plantaginis 20-120 part, Herba Lycopodii 10-35 part.
Radix Glycyrrhizae containing glycyrrhizic acid and glycyrrhizin etc., has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effects such as coordinating the actions of various ingredients in a prescription, uses herein, mainly the effect of heat clearing and inflammation relieving, mediation and protecting spleen and stomach.
Herba Plantaginis, is commonly called as " Herba Potentillae Chinensis ", " Semen Plantaginis ", annual herb plant.Taproot is long, tool most sides root, how many meats.Rhizome is short.Phyllopodium is raw in rosette-stape, flat sleeping, tiltedly exhibition or upright; Blade papery, ellipse, ellipticity lanceolar or ovum shape lanceolar, long 3-12 centimetre, wide 1-3.5 centimetre, the anxious point or micro-blunt of tip, the shallow wavy cognate of edge tool, irregular sawtooth or tooth, the wide wedge shape of base portion to narrow wedge shape, under be extended down to petiole. arteries and veins 5-7 bar, above slightly depression, obviously swell in the back side, raw white pubescence is dredged on two sides; The long 2-6 centimetre of petiole, base portion is expanded into constitute sheath-like.There is effect of diuresis, damp eliminating, heat clearing away, improving eyesight.
Herba Lycopodii another name Radix et Rhizoma Smilacis Ripariae, large along muscle rattan, Radix Schisandrae Micranthae, muscle stretched by the Radix Stemonae, and water shakes bamboo etc., perennial herb, and stolon is in carefully cylindrical, and slightly bending, length can reach 2m, diameter 1-3mm, has yellow-white radicula under it.Erect stern makes two dichotomies.On Ye Misheng stem, helical arrangement, shrinkage bends, linear or aciculiform, long 3-5mm, and yellow green is extremely fallow, without hair, tip aristiform, Quan Yuan, easily cataclasm.Matter is soft, and section skin zone is light yellow, woody part off-white color.Odorless, lightly seasoned.Have expelling wind and cold, dehumidifying detumescence, the effect of relaxing muscles and tendons and activating QI and blood in the collateral, can be used for anemofrigid-damp arthralgia, and muscle arteries and veins contracture pain carbuncle, external is controlled osteopatia sprain and swollen and ache.
Chinese medicine composition provided by the invention, Radix Glycyrrhizae, Flos Lonicerae, coordinated enhancing between Herba Plantaginis and Herba Lycopodii, there is antiinflammatory, pain relieving and extraordinary uricotelic effect, increase discharge capacity and reduce uric acid, therapeutic effect significantly, and has blood pressure lowering, liver heat removing and eyesight improving, shade the effect such as fertilizer, expelling phlegm for arresting cough.
In order to strengthen the mutual chemiluminescence between each raw material further, preferably, by weight, Radix Glycyrrhizae 5-10 part, Flos Lonicerae 10-18 part, Herba Plantaginis 50-100 part, Herba Lycopodii 15-30 part.
More preferably, by weight, Radix Glycyrrhizae 7-8 part, Flos Lonicerae 12-15 part, Herba Plantaginis 70-80 part, Herba Lycopodii 20-25 part.
Present invention also offers the preparation method of described Chinese medicine composition, get each raw material by weight, decoct with water.
This preparation method is undertaken by the mode of decocting, simple, and in the extract obtained, effective active component content is high, and in the process decocted, the interphase interaction of each effective active composition, has carried out effective high temperature and merged, had better therapeutic effect.
Further, each raw material first carries out remove impurity before decoction, and then dry in the sun is to leather hard, is cleaned up, and dries, cutting or section.By remove impurity to make each raw material more pure, prevent the interference of other impurity; To be cleaned again by first dry in the sun, then by drying cutting or section, to be easy to the stripping of the effective active composition when soak by water.
Preferably, described decoction is: first boil with big fire, then turns down the slow stewed 5-10min of fire.Stewed with the slow of little fire by boiling of big fire, flavour of a drug are overflowed completely, the abundant stripping of effective active composition.Wherein, big fire refers generally to power at more than 1600W; Little fire refers generally to power at below 1000W.
In order to make the abundant stripping of effective active composition in each raw material, preferably, described water is 15 ~ 30:1 with the gross weight ratio of each raw material, is more preferably 20 ~ 25:1.
Present invention also offers the application of described Chinese medicine composition in preparation treatment gout medicine.
Present invention also offers the application of described Chinese medicine composition in preparation treatment Altace Ramipril.
Present invention also offers the application of described Chinese medicine composition in preparation treatment liver heat removing and eyesight improving and expelling phlegm for arresting cough medicine.
Chinese medicine composition provided by the invention has the effect of antiinflammatory, pain relieving, uric acid resisting, mainly by releasing uric acid, repairs metabolism, gets rid of uric acid road calculus, and finally reach the antipodagric object of root.
Meanwhile, this Chinese medicine composition also has the effects such as blood pressure lowering, liver heat removing and eyesight improving, expelling phlegm for arresting cough, and side effect is very little, can be made into herbal tea health preserving, and this can prevent the diseases such as gout.
Compared with prior art, beneficial effect of the present invention is:
(1) specific these the 4 kinds of Chinese herbal medicine of Radix Glycyrrhizae, Flos Lonicerae, Herba Plantaginis and Herba Lycopodii of selecting of the present invention are used in conjunction with each other, and the consumption limited between each raw material, between each raw material, coordinated strengthens, there is effect of antiinflammatory, pain relieving and extraordinary releasing uric acid uric acid resisting, therapeutic effect is remarkable, and there is blood pressure lowering, liver heat removing and eyesight improving, expelling phlegm for arresting cough, pathogenic fire reducing, decorporation are let out, steady metabolism, shade the effect such as fertile;
(2) in order to strengthen the collaborative reinforced effects between each raw material further, the present invention also further defines the consumption between each raw material;
(3) present invention also offers the preparation method of described Chinese medicine composition, the mode of decocting is selected to process, simple, in the extract obtained, effective active component content is high, and in the process decocted, the interphase interaction of each effective active composition, has carried out effective high temperature and has merged, had better therapeutic effect;
(4) the present invention is also by carrying out pretreatment to each raw material, to be easy to the stripping of the effective active composition when soak by water;
(5) the present invention is also by limiting the mode of amount of water and the decoction decocted, and make the abundant stripping of effective active composition in each raw material, fully merge, in the extracting solution obtained, effective active component content is high, takes rear good absorbing, increases therapeutic effect.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting the scope of the invention.Unreceipted actual conditions person in embodiment, the condition of conveniently conditioned disjunction manufacturer suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, being can by the conventional products of commercially available acquisition.
Embodiment 1
Get following raw material: Radix Glycyrrhizae 2g, Flos Lonicerae 20g, Herba Plantaginis 20g, Herba Lycopodii 35g;
By each impurity removing, then dry in the sun is to leather hard, is cleaned up, and dries, cutting or section;
Add water 2310ml, first boils with big fire, then turns down the slow stewed 10min of fire.
Embodiment 2
Get following raw material: Radix Glycyrrhizae 5g, Flos Lonicerae 10g, Herba Plantaginis 100g, Herba Lycopodii 15g;
By each impurity removing, then dry in the sun is to leather hard, is cleaned up, and dries, cutting or section;
Add water 2400ml, first boils with big fire, then turns down the slow stewed 7min of fire.
Embodiment 3
Get following raw material: Radix Glycyrrhizae 7g, Flos Lonicerae 15g, Herba Plantaginis 80g, Herba Lycopodii 20g;
By each impurity removing, then dry in the sun is to leather hard, is cleaned up, and dries, cutting or section;
Add water 2200ml, first boils with big fire, then turns down the slow stewed 6min of fire.
Embodiment 4
Get following raw material: Radix Glycyrrhizae 8g, Flos Lonicerae 12g, Herba Plantaginis 70g, Herba Lycopodii 25g;
By each impurity removing, then dry in the sun is to leather hard, is cleaned up, and dries, cutting or section;
Add water 2300ml, first boils with big fire, then turns down the slow stewed 8min of fire.
Embodiment 5
Get following raw material: Radix Glycyrrhizae 10g, Flos Lonicerae 18g, Herba Plantaginis 50g, Herba Lycopodii 30g;
By each impurity removing, then dry in the sun is to leather hard, is cleaned up, and dries, cutting or section;
Add water 2700ml, first boils with big fire, then turns down the slow stewed 9min of fire.
Embodiment 6
Get following raw material: Radix Glycyrrhizae 15g, Flos Lonicerae 5g, Herba Plantaginis 120g, Herba Lycopodii 10g;
By each impurity removing, then dry in the sun is to leather hard, is cleaned up, and dries, cutting or section;
Add water 2250ml, first boils with big fire, then turns down the slow stewed 5min of fire.
Experimental example 1
Repeat embodiment 1-6, obtained abundant medicinal liquid is used for experimental example and takes, and wherein, each embodiment selects 50 patient with gout to take, and takes 3 months, every day one auxiliary medicine, before or after meals all can be taken, and the dose of every day is 1500-2000ml, then adds up effect; Application number is the formula of the preferred version of 201210416621.9 description 0019-0028 sections, the medicinal liquid made with reference to the preparation method of description 0061-0063 section as a control group, select 50 patient with gout to take according to quantity, take 3 months, statistics therapeutic effect.
Effect is divided into healing, effective and invalid, cures as gout transference cure; Effectively obviously alleviate for gout symptom; Invalid is that gout symptom is without significant change.The result obtained is as shown in table 1.
The statistics effect of table 1 patient with gout
| Group | Cure | Effectively | Invalid |
| Embodiment 1 | 48 | 2 | 0 |
| Embodiment 2 | 49 | 1 | 0 |
| Embodiment 3 | 50 | 0 | 0 |
| Embodiment 4 | 49 | 1 | 0 |
| Embodiment 5 | 48 | 2 | 0 |
| Embodiment 6 | 49 | 1 | 0 |
| Matched group | 42 | 6 | 2 |
As can be seen from Table 1, the cure rate of Chinese medicine composition provided by the invention to patient with gout reaches more than 96%, has the therapeutic effect of highly significant.In addition, take period without any discomfort generation, and appetite strengthens.
Metabolic disturbance, urate excretion are not smooth, adopt Chinese medicine composition provided by the invention to nurse one's health, and make metabolism recover normal, get rid of uric acid road calculus, thus radical cure gout.But need auxiliaryly to treat in a conventional method at acute attack stage.
The medicinal liquid of Chinese medicine composition provided by the invention is a treatment phase in 15-20 days before taking, and dose can suitably increase, and is one-period by 30 days, second period by 60 days, it within 100 days, is the 3rd cycle, if severe patient, about can half a year being taken according to practical situation.
The food that the not edible purine albumen of period in a medicine is too high, such as internal organs, seafood, bean food, do not drink, edible stodge of trying not.After rehabilitation, what can be eaten, but will form healthy dietary habit.
Concrete clinical example:
1. Zhang, man, Luzhou, Sichuan people, 30 years old, is diagnosed as gout, repeatedly treats through hospital, is only by Morbidity control, does not thoroughly eradicate; After start to take Chinese medicine provided by the invention, within front 15-20 days that take medicine, because the state of an illness is relatively serious, significantly do not feel, but take medicine about 30 days time, the state of an illness is controlled, and sickness rate obviously reduces, after continue to take medicine, almost nil to sickness rate when about 60 days.Returned to one's perfect health time about 100 days.Up to now, gout does not recur again, and life is not also affected.
2. Lee, man, people from Chengdu, Sichuan, 35 years old, is diagnosed as gout, repeatedly treats to hospital, though the state of an illness is controlled, but is not effected a radical cure.Started afterwards to take Chinese medicine provided by the invention, because the state of an illness is more serious, within first 10 days that take medicine, significantly do not feel, take medicine about 30 days time, the state of an illness is controlled, and sickness rate obviously reduces, and rear continuing is taken medicine, almost nil to sickness rate when about 60 days, returned to one's perfect health time about 90 days.Up to now, gout does not recur again, and life is not also affected.
Experimental example 2
Obtain abundant medicinal liquid by embodiment 1-6 to take for experimental example, wherein, each embodiment selects 50 hyperpietics to take, and takes 2 months, every day one auxiliary medicine, before or after meals all can be taken, and the dose of every day is 1500-2000ml, then adds up effect.
Effect is divided into healing, effective and invalid, cures as blood pressure is down to normally, no longer needs to take depressor; Effectively obviously decline for blood pressure, still need to take a small amount of depressor; Invalid is that blood pressure is without significant change.The result obtained is as shown in table 2.
The statistics effect of table 2 hyperpietic
| Group | Cure | Effectively | Invalid |
| Embodiment 1 | 47 | 3 | 0 |
| Embodiment 2 | 49 | 1 | 0 |
| Embodiment 3 | 50 | 0 | 0 |
| Embodiment 4 | 49 | 1 | 0 |
| Embodiment 5 | 48 | 2 | 0 |
| Embodiment 6 | 48 | 2 | 0 |
As can be seen from Table 2, Chinese medicine composition provided by the invention has the therapeutic effect of highly significant to hyperpietic.In addition, take period without any discomfort generation, and appetite strengthens.
In addition, Chinese medicine composition provided by the invention is also applied to the symptom such as liver heat removing and eyesight improving, expelling phlegm for arresting cough; As suffered from the patient of tracheitis or flu, carrying out decoction by Chinese medicine composition provided by the invention and taking, obviously can alleviate by sensory symptoms after taking three days, can cure after taking 10 days, play the effect of extraordinary expelling phlegm for arresting cough, liver heat removing and eyesight improving.
Make herbal tea by this formula to drink, also have pathogenic fire reducing, decorporation is let out, steady metabolism, and shade fertilizer, steady blood pressure lowering, the health-care effecies such as liver heat removing and eyesight improving, and has no side effect.
Chinese medicine composition provided by the invention has the following advantages:
(1) add raw material type few, select these 4 kinds of Chinese herbal medicine of Radix Glycyrrhizae, Flos Lonicerae, Herba Plantaginis and Herba Lycopodii to be used in conjunction with each other, produce when taking without any discomfort, safety has no side effect;
(2) the specific and consumption limited between each raw material of the present invention, between each raw material, coordinated strengthens, and has antiinflammatory, pain relieving, extraordinary uricotelic effect, increases discharge capacity and reduces uric acid.Therapeutic effect is thorough, is not easy recurrence; And there is steady blood pressure lowering, liver heat removing and eyesight improving, expelling phlegm for arresting cough, pathogenic fire reducing, decorporation are let out, steady metabolism, shade the effect such as fertile;
(3) preparation method of described Chinese medicine composition provided by the invention, the mode of decocting is selected to process, simple, in the extract obtained, effective active component content is high, and in the process decocted, the interphase interaction of each effective active composition, has carried out effective high temperature and has merged, had better therapeutic effect;
(4) the present invention is also by carrying out pretreatment to each raw material, to be easy to the stripping of the effective active composition when soak by water;
(5) the present invention is also by limiting the mode of amount of water and the decoction decocted, and make the abundant stripping of effective active composition in each raw material, fully merge, in the extracting solution obtained, effective active component content is high, takes rear good absorbing, increases therapeutic effect.
Although illustrate and describe the present invention with specific embodiment, however it will be appreciated that can to make when not deviating from the spirit and scope of the present invention many other change and amendment.Therefore, this means to comprise all such changes and modifications belonged in the scope of the invention in the following claims.
Claims (10)
1. a Chinese medicine composition, is characterized in that, makes primarily of following raw material, by weight, and Radix Glycyrrhizae 2-15 part, Flos Lonicerae 5-20 part, Herba Plantaginis 20-120 part, Herba Lycopodii 10-35 part.
2. Chinese medicine composition according to claim 1, is characterized in that, by weight, and Radix Glycyrrhizae 5-10 part, Flos Lonicerae 10-18 part, Herba Plantaginis 50-100 part, Herba Lycopodii 15-30 part.
3. Chinese medicine composition according to claim 1, is characterized in that, by weight, and Radix Glycyrrhizae 7-8 part, Flos Lonicerae 12-15 part, Herba Plantaginis 70-80 part, Herba Lycopodii 20-25 part.
4. the preparation method of Chinese medicine composition described in any one of claim 1-3, is characterized in that, gets each raw material by weight, decocts with water.
5. preparation method according to claim 4, is characterized in that, each raw material first carries out remove impurity before decoction, and then dry in the sun is to leather hard, is cleaned up, and dries, cutting or section.
6. preparation method according to claim 4, is characterized in that, described decoction is: first boil with big fire, then turns down the slow stewed 5-10min of fire.
7. preparation method according to claim 4, is characterized in that, described water is 15 ~ 30:1 with the gross weight ratio of each raw material, is preferably 20 ~ 25:1.
8. the application of Chinese medicine composition described in any one of claim 1-3 in preparation treatment gout medicine.
9. the application of Chinese medicine composition described in any one of claim 1-3 in preparation treatment Altace Ramipril.
10. the application of Chinese medicine composition described in any one of claim 1-3 in preparation treatment liver heat removing and eyesight improving and expelling phlegm for arresting cough medicine.
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| CN115487272A (en) * | 2022-10-18 | 2022-12-20 | 陈炎光 | Traditional Chinese medicine composition for preventing and treating critical hyperuricemia and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106361968A (en) * | 2016-10-08 | 2017-02-01 | 宋整 | Traditional Chinese medicine tablets and preparation method thereof |
| CN115487272A (en) * | 2022-10-18 | 2022-12-20 | 陈炎光 | Traditional Chinese medicine composition for preventing and treating critical hyperuricemia and preparation method thereof |
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