CN105497495A - Traditional Chinese medicine composition with anti-fatigue effect and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition with anti-fatigue effect and preparation method and application thereof Download PDFInfo
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition with an anti-fatigue effect and a preparation method and application thereof. According to the traditional Chinese medicine composition, channel tropism, properties and flavors of traditional Chinese medicines such as ginseng, dry mature fruit of fructus schizandrae chinensis, radix ophiopogonis, fructus lycii and salviae miltiorrhizae are fully considered, the ratio of the traditional Chinese medicines is selected, the traditional Chinese medicines can cooperate with one another and act together according to the compatibility of monarch, minister, assistant and guide, and therefore the traditional Chinese medicines act on focus, and the anti-fatigue treatment effect is brought into play. Experiments show that swimming endurance can be obviously enhanced through the traditional Chinese medicine composition, the anti-fatigue effect is achieved, and the traditional Chinese medicine composition can be used as a potential anti-fatigue medicine.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition with antifatigue effect and preparation method thereof and purposes.
Background technology
Fatigue is a comprehensive physiological process relating to many Physiology and biochemistry factors, that the mental or physical exertion of human body is to the normal physiological phenomenon of the one that must occur during certain phase, it had both indicated the temporary transient decline of the original ability to work of body, may be again the tendency that body develops into sick and wounded state.Human body feels tired, although swift and violent unlike the oncoming force such as cancer, heart disease, directly and promptly cause death, it, as a kind of stealthy killer endangering modern's health, has had a strong impact on work and the life of people, considerably increased sub-health population quantity.Under human body is in fatigue state for a long time, can produce geromorphism and fatigue syndrome, overfatigue even can accelerate death.
Chinese patent literature CN104605357A discloses a kind of functional health product of conditioning subhealthy state, be made up of the Chinese medicine of following weight: Radix Astragali 20g, Rhizoma Polygonati 20g, Rhizoma Dioscoreae 20g, Semen Nelumbinis 20g, Fructus Amomi 10g, Ganoderma 10g, Poria 20g, Fructus Crataegi 20 grams, Fructus Lycii 20g, Radix Polygoni Multiflori 20g, Flos Chrysanthemi 10g, Radix Paeoniae Alba 10g, Radix Bupleuri 10g, Rhizoma Cyperi 10g, Radix Achyranthis Bidentatae 10g, Radix Morindae Officinalis 10g, Fructus Ligustri Lucidi 20g, Radix Rehmanniae Preparata 10g, Carapax Et Plastrum Testudinis 10g, Radix Panacis Quinquefolii 6g, Rhizoma Gastrodiae 6g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 10g, Flos Carthami 10g, Radix Salviae Miltiorrhizae 20g, Folium Ginkgo 10g, Radix Notoginseng 6g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 10g, Pheretima 6g, Cornu Cervi Pantotrichum 6g, Cortex Cinnamomi 6g and Radix Glycyrrhizae 6g.But above-mentioned Chinese medicine composition exists the shortcomings such as composition is complicated, cost is higher, thus limit its application.
Therefore, study that novel therapeutic effect is good, toxic and side effects is little, it is significant to form the medicine of simple, lower-cost antifatigue effect.
Summary of the invention
Therefore, the invention provides the Chinese medicine composition with antifatigue effect that a kind of therapeutic effect is good, toxic and side effects is little, and then its preparation method and purposes are provided.
For solving the problems of the technologies described above, the present invention is achieved through the following technical solutions:
The invention provides a kind of Chinese medicine composition with antifatigue effect, the crude drug of described Chinese medicine composition consists of:
Radix Ginseng 3-9 weight portion, Fructus Schisandrae Chinensis 3-9 weight portion, Radix Ophiopogonis 6-10 weight portion, Fructus Lycii 6-10 weight portion, Radix Salviae Miltiorrhizae 6-12 weight portion.
Preferably, the above-mentioned Chinese medicine composition with antifatigue effect of the present invention, the crude drug of described Chinese medicine composition consists of:
Radix Ginseng 3 weight portion, Fructus Schisandrae Chinensis 6-8 weight portion, Radix Ophiopogonis 6-7 weight portion, Fructus Lycii 6-7 weight portion, Radix Salviae Miltiorrhizae 6-7 weight portion.
Further preferably, the above-mentioned Chinese medicine composition with antifatigue effect of the present invention, the crude drug of described Chinese medicine composition consists of:
Radix Ginseng 3 weight portion, Fructus Schisandrae Chinensis 6.7 weight portion, Radix Ophiopogonis 6.6 weight portion, Fructus Lycii 6.6 weight portion, Radix Salviae Miltiorrhizae 6 weight portion; Or
Radix Ginseng 3 weight portion, Fructus Schisandrae Chinensis 8 weight portion, Radix Ophiopogonis 7 weight portion, Fructus Lycii 7 weight portion, Radix Salviae Miltiorrhizae 7 weight portion; Or
Radix Ginseng 3 weight portion, Fructus Schisandrae Chinensis 6 weight portion, Radix Ophiopogonis 6 weight portion, Fructus Lycii 6 weight portion, Radix Salviae Miltiorrhizae 6 weight portion.
The present invention also provides the above-mentioned preparation method with the Chinese medicine composition of antifatigue effect, comprises the following steps:
(1) get the Radix Ginseng of selected weight portion, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae and Fructus Lycii respectively, then decoct with water 1-3 time, each 1-3 hour, add the water of the 8-12 times amount of above-mentioned raw materials medicine gross weight at every turn, obtain decoction liquor A;
(2) get the Radix Ophiopogonis of selected weight portion, then decoct with water 1-3 time, each 0.5-2 hour, add the water of 8-12 weight times amount at every turn, obtain decoction liquor B;
(3) merged by described decoction liquor A and described decoction liquor B, concentrated, staticly settle, it is the clear paste of 1.00-1.30 that supernatant concentration obtains relative density at 50 DEG C.
Preferably, the above-mentioned preparation method with the Chinese medicine composition of antifatigue effect of the present invention, comprises the following steps:
(1) Radix Ginseng of selected weight portion, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae and Fructus Lycii is got respectively, then 2 times are decocted with water, add the water of the 9-11 times amount of above-mentioned raw materials medicine gross weight for the first time, decoct 1.5-2.5 hour, second time adds the water of the 9-11 times amount of above-mentioned raw materials medicine gross weight, decoct 1-2 hour, obtain decoction liquor A;
(2) get the Radix Ophiopogonis of selected weight portion, then decoct with water 2 times, each 0.5-1.5 hour, add the water of 9-11 weight times amount for the first time, second time adds the water of 7-9 weight times amount, obtains decoction liquor B;
(3) merged by described decoction liquor A and described decoction liquor B, concentrated, staticly settle, it is the clear paste of 1.05-1.20 that supernatant concentration obtains relative density at 50 DEG C.
Further preferably, the above-mentioned preparation method with the Chinese medicine composition of antifatigue effect of the present invention, comprises the following steps:
(1) Radix Ginseng of selected weight portion, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae and Fructus Lycii is got respectively, then 2 times are decocted with water, add the water of 10 times amount of above-mentioned raw materials medicine gross weight for the first time, decoct 2 hours, second time adds the water of 8 times amount of above-mentioned raw materials medicine gross weight, decoct 1.5 hours, obtain decoction liquor A;
(2) get the Radix Ophiopogonis of selected weight portion, then decoct with water 2 times, each 1 hour, add the water of 10 weight times amount for the first time, second time adds the water of 8 weight times amount, obtains decoction liquor B;
(3) merged by described decoction liquor A and described decoction liquor B, concentrated, staticly settle, it is the clear paste of 1.10-1.15 that supernatant concentration obtains relative density at 50 DEG C.
The present invention also provides to comprise above-mentionedly to be had the preparation of the Chinese medicine composition of antifatigue effect or comprises the preparation of the Chinese medicine composition that above-mentioned preparation method prepares,
Described Chinese medicine composition adds customary adjuvant, conveniently technique, makes acceptable oral liquid, granule, tablet, capsule, powder, pill, syrup or unguentum clinically.
Described customary adjuvant is: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linked carboxymethyl cellulose are received; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are fixed, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods; Substrate comprises: PEG6000, PEG4000, insect wax etc.
The application had in the medicine of antifatigue effect prepared by the Chinese medicine composition that the present invention also provides above-mentioned Chinese medicine composition, above-mentioned preparation method prepares or the preparation of above-mentioned Chinese medicine composition.
Technical scheme tool of the present invention has the following advantages:
[Radix Ginseng] is warm in nature, flat, sweet in the mouth, micro-hardship; Return spleen, lung meridian, heart channel; Effect: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.
[Fructus Schisandrae Chinensis] is warm in nature, sweet in the mouth, acid; Return lung meridian, kidney channel, heart channel; Effect: supplementing QI for promoting the production of body fluid, the kidney invigorating is nourished heart, and restrains astringent or styptic treatment for spontaneous sweating.
[Radix Ophiopogonis] cold nature, sweet in the mouth, hardship; Return lung meridian, heart channel, stomach warp; Effect: nourishing YIN and moistening the lung, reinforcing stomach reg fluid, clear away heart-fire relieving restlessness.
[Fructus Lycii] property is sweet, and taste is put down; Return Liver Channel, kidney channel, lung meridian; Effect: nourishing the liver and kidney, improving eyesight, lung moistening.
[Radix Salviae Miltiorrhizae] cold nature, bitter in the mouth; GUIXIN warp, Liver Channel; Effect: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.
The present invention has the Chinese medicine composition of antifatigue effect, take into full account each Chinese medicine of Radix Ginseng, Fructus Schisandrae Chinensis, Radix Ophiopogonis, Fructus Lycii and Radix Salviae Miltiorrhizae return through and nature and flavor, and select each Chinese medicine proportioning each other, make that each Chinese medicine cooperatively interacts according to the compatibility relationship of " monarch, minister, help, make ", combined effect, thus act on focus, and then play the curative effect of antifatigue effect.In addition, the Chinese medicine composition that the present invention has antifatigue effect only comprises five kinds of Chinese medicines, and composition is simple, cost is lower.
Detailed description of the invention
To be clearly and completely described technical scheme of the present invention below, obviously, described embodiment is the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
embodiment 1
The crude drug that the present embodiment has the Chinese medicine composition of antifatigue effect consists of:
Radix Ginseng 3g, Fructus Schisandrae Chinensis 6.7g, Radix Ophiopogonis 6.6g, Fructus Lycii 6.6g, Radix Salviae Miltiorrhizae 6g;
The preparation method of this Chinese medicine composition, comprises the following steps:
(1) get the Radix Ginseng of selected weight, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae and Fructus Lycii respectively, then decoct with water 2 times, add the water of 10 times amount of above-mentioned raw materials medicine gross weight for the first time, decoct 2 hours, second time adds the water of 8 times amount of above-mentioned raw materials medicine gross weight, decocts 1.5 hours, obtains decoction liquor A;
(2) get the Radix Ophiopogonis of selected weight portion, then decoct with water 2 times, each 1 hour, add the water of 10 weight times amount for the first time, second time adds the water of 8 weight times amount, obtains decoction liquor B;
(3) merged by described decoction liquor A and described decoction liquor B, concentrated, staticly settle, it is the clear paste of 1.10-1.15 that supernatant concentration obtains relative density at 50 DEG C.
The Chinese medicine composition that the present embodiment has antifatigue effect adds customary adjuvant, conveniently technique, makes oral liquid.
embodiment 2
The crude drug that the present embodiment has the Chinese medicine composition of antifatigue effect consists of:
Radix Ginseng 3g, Fructus Schisandrae Chinensis 8g, Radix Ophiopogonis 7g, Fructus Lycii 7g, Radix Salviae Miltiorrhizae 7g;
The preparation method of this Chinese medicine composition, comprises the following steps:
(1) get the Radix Ginseng of selected weight portion, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae and Fructus Lycii respectively, then decoct with water 2 times, add the water of 9 times amount of above-mentioned raw materials medicine gross weight for the first time, decoct 2.5 hours, second time adds the water of 9 times amount of above-mentioned raw materials medicine gross weight, decocts 2 hours, obtains decoction liquor A;
(2) get the Radix Ophiopogonis of selected weight portion, then decoct with water 2 times, each 0.5 hour, add the water of 9 weight times amount for the first time, second time adds the water of 7 weight times amount, obtains decoction liquor B;
(3) merged by described decoction liquor A and described decoction liquor B, concentrated, staticly settle, it is the clear paste of 1.05-1.10 that supernatant concentration obtains relative density at 50 DEG C.
The Chinese medicine composition that the present embodiment has antifatigue effect adds customary adjuvant, conveniently technique, makes capsule.
embodiment 3
The crude drug that the present embodiment has the Chinese medicine composition of antifatigue effect consists of:
Radix Ginseng 3g, Fructus Schisandrae Chinensis 6g, Radix Ophiopogonis 6g, Fructus Lycii 6g, Radix Salviae Miltiorrhizae 6g;
The preparation method of this Chinese medicine composition, comprises the following steps:
(1) Radix Ginseng of selected weight portion, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae and Fructus Lycii is got respectively, then 2 times are decocted with water, add the water of 11 times amount of above-mentioned raw materials medicine gross weight for the first time, decoct 1.5 hours, second time adds the water of 11 times amount of above-mentioned raw materials medicine gross weight, decoct 1 hour, obtain decoction liquor A;
(2) get the Radix Ophiopogonis of selected weight portion, then decoct with water 2 times, each 1.5 hours, add the water of 11 weight times amount for the first time, second time adds the water of 9 weight times amount, obtains decoction liquor B;
(3) merged by described decoction liquor A and described decoction liquor B, concentrated, staticly settle, it is the clear paste of 1.10-1.20 that supernatant concentration obtains relative density at 50 DEG C.
The Chinese medicine composition that the present embodiment has antifatigue effect adds customary adjuvant, conveniently technique, makes tablet.
experimental examplethe research of Chinese medicine composition antifatigue effect of the present invention
With male mice, body weight 25 ~ 28g, random packet, the first experimental group 10, the second experimental group 10, matched group 10.
First experimental group, the second experimental group gavage respectively oral liquid (by crude drug) 5g/kg/ day prepared by embodiment 1 (10 times to clinical dosage, LD
50/10) and 10g/kg/ day (20 times to clinical dosage, Lg
50/5), every day 1 time; Matched group gavages 0.5mL normal saline 1 time every day; Continue 24.From administration the 4th day, each treated animal to soak in 25 DEG C ~ 30 DEG C deep water middle reaches every day 3.5 hours as stress, continue three weeks.Administration carries out exercise tolerance experiment on the 25th day.Its swimming state is observed, time of change and judge its endurance in swimming test process.
Put by mice in deep water, swim voluntarily, its nose, eye, the crown and ears are all exposed at the water surface, and two metapedes are struck, and straight line is swum, and shows that power is contained; Struck as two metapedes draw slowly or not, the water surface covers ears, the submergence crown, shows that power declines, certainly entering the time that water most declines is the animal movement endurance time.Each group of mice is stress after three weeks, and the measured endurance time is as shown in table 1.
Table 1 is on the impact of Tolerance of Swimming time
As shown in Table 1, the swimming endurance time of the first experimental group, the swimming endurance time of the second experimental group are all longer than swimming endurance time of matched group, all have significant.This shows, oral liquid prepared by embodiment 1 obviously can strengthen Tolerance of Swimming, has antifatigue effect.
In sum, Chinese medicine composition of the present invention obviously can strengthen swimming endurance, has antifatigue effect, can as the medicine of potential resisting fatigue.
Obviously, above-described embodiment is only for clearly example being described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And thus the apparent change of extending out or variation be still among the protection domain of the invention.
Claims (8)
1. have a Chinese medicine composition for antifatigue effect, it is characterized in that, the crude drug of described Chinese medicine composition consists of:
Radix Ginseng 3-9 weight portion, Fructus Schisandrae Chinensis 3-9 weight portion, Radix Ophiopogonis 6-10 weight portion, Fructus Lycii 6-10 weight portion, Radix Salviae Miltiorrhizae 6-12 weight portion.
2. the Chinese medicine composition with antifatigue effect according to claim 1, is characterized in that, the crude drug of described Chinese medicine composition consists of:
Radix Ginseng 3 weight portion, Fructus Schisandrae Chinensis 6-8 weight portion, Radix Ophiopogonis 6-7 weight portion, Fructus Lycii 6-7 weight portion, Radix Salviae Miltiorrhizae 6-7 weight portion.
3. the Chinese medicine composition with antifatigue effect according to claim 2, is characterized in that, the crude drug of described Chinese medicine composition consists of:
Radix Ginseng 3 weight portion, Fructus Schisandrae Chinensis 6.7 weight portion, Radix Ophiopogonis 6.6 weight portion, Fructus Lycii 6.6 weight portion, Radix Salviae Miltiorrhizae 6 weight portion; Or
Radix Ginseng 3 weight portion, Fructus Schisandrae Chinensis 8 weight portion, Radix Ophiopogonis 7 weight portion, Fructus Lycii 7 weight portion, Radix Salviae Miltiorrhizae 7 weight portion; Or
Radix Ginseng 3 weight portion, Fructus Schisandrae Chinensis 6 weight portion, Radix Ophiopogonis 6 weight portion, Fructus Lycii 6 weight portion, Radix Salviae Miltiorrhizae 6 weight portion.
4. the preparation method with the Chinese medicine composition of antifatigue effect described in any one of claim 1-3, is characterized in that, comprise the following steps:
(1) get the Radix Ginseng of selected weight portion, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae and Fructus Lycii respectively, then decoct with water 1-3 time, each 1-3 hour, add the water of the 8-12 times amount of above-mentioned raw materials medicine gross weight at every turn, obtain decoction liquor A;
(2) get the Radix Ophiopogonis of selected weight portion, then decoct with water 1-3 time, each 0.5-2 hour, add the water of 8-12 weight times amount at every turn, obtain decoction liquor B;
(3) merged by described decoction liquor A and described decoction liquor B, concentrated, staticly settle, it is the clear paste of 1.00-1.30 that supernatant concentration obtains relative density at 50 DEG C.
5. the preparation method with the Chinese medicine composition of antifatigue effect according to claim 4, is characterized in that, comprise the following steps:
(1) Radix Ginseng of selected weight portion, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae and Fructus Lycii is got respectively, then 2 times are decocted with water, add the water of the 9-11 times amount of above-mentioned raw materials medicine gross weight for the first time, decoct 1.5-2.5 hour, second time adds the water of the 9-11 times amount of above-mentioned raw materials medicine gross weight, decoct 1-2 hour, obtain decoction liquor A;
(2) get the Radix Ophiopogonis of selected weight portion, then decoct with water 2 times, each 0.5-1.5 hour, add the water of 9-11 weight times amount for the first time, second time adds the water of 7-9 weight times amount, obtains decoction liquor B;
(3) merged by described decoction liquor A and described decoction liquor B, concentrated, staticly settle, it is the clear paste of 1.05-1.20 that supernatant concentration obtains relative density at 50 DEG C.
6. the preparation method with the Chinese medicine composition of antifatigue effect according to claim 5, is characterized in that, comprise the following steps:
(1) Radix Ginseng of selected weight portion, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae and Fructus Lycii is got respectively, then 2 times are decocted with water, add the water of 10 times amount of above-mentioned raw materials medicine gross weight for the first time, decoct 2 hours, second time adds the water of 8 times amount of above-mentioned raw materials medicine gross weight, decoct 1.5 hours, obtain decoction liquor A;
(2) get the Radix Ophiopogonis of selected weight portion, then decoct with water 2 times, each 1 hour, add the water of 10 weight times amount for the first time, second time adds the water of 8 weight times amount, obtains decoction liquor B;
(3) merged by described decoction liquor A and described decoction liquor B, concentrated, staticly settle, it is the clear paste of 1.10-1.15 that supernatant concentration obtains relative density at 50 DEG C.
7. comprise the preparation with the Chinese medicine composition of antifatigue effect described in any one of claim 1-3 or comprise the preparation of the Chinese medicine composition that the preparation method described in any one of claim 4-6 prepares, it is characterized in that,
Described Chinese medicine composition adds customary adjuvant, conveniently technique, makes acceptable oral liquid, granule, tablet, capsule, powder, pill, syrup or unguentum clinically.
8. the application had in the medicine of antifatigue effect prepared by the preparation of the Chinese medicine composition that the Chinese medicine composition described in any one of claim 1-3, preparation method described in any one of claim 4-6 prepare or Chinese medicine composition according to claim 7.
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