CN105497496B - It is a kind of with Chinese medicine composition and preparation method thereof and purposes for improving male's sexual effect - Google Patents
It is a kind of with Chinese medicine composition and preparation method thereof and purposes for improving male's sexual effect Download PDFInfo
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Abstract
The invention belongs to the field of Chinese medicines, and in particular to a kind of with Chinese medicine composition for improving male's sexual effect and preparation method thereof and purposes.The present invention has the Chinese medicine composition for improving male's sexual effect, fully consider the channel tropism and nature and flavor of ginseng, Schisandra chinensis, Radix Ophiopogonis, fructus lycii and each Chinese medicine of Radix Salviae Miltiorrhizae, and the proportion for selecting each Chinese medicine mutual, each Chinese medicine is set to cooperate according to the compatibility relationship of " monarch, minister, help, make ", collective effect, to act on lesion, and then play the curative effect for improving male's sexual effect.Experiment shows that the sexual function of buck can be improved in the Chinese medicine composition, can be used as the potential drug for improving male's sexual.
Description
Technical field
The invention belongs to the field of Chinese medicines, and in particular to it is a kind of with improve male's sexual effect Chinese medicine composition and its
Preparation method and purposes.
Background technique
Recently as the increase of operating pressure and life stress, the patient of sex dysfunction or hypogona dism disease is got over
Come more, seriousness increasingly causes the attention of people.The reason of sex dysfunction or hypogona dism disease occur is very
It is more.For a long time, the effect is unsatisfactory for western medicine sex dysfunction or hypogona dism, and takes Western medicine for a long time and be easy
Drug resistance is generated, toxic side effect is larger, seriously damages the hepatic and renal function of patient.
Chinese patent literature CN102716260A discloses a kind of drug for quickly improving sperm quality and sexual function, under
The material medicine for stating parts by weight is prepared: 6-60 parts of fructus lycii, 6-60 parts of Herba Epimedii, and 6-60 parts of the fleece-flower root, 6-60 parts of Radix Salviae Miltiorrhizae,
3-45 parts of cortex acanthopanacis, 6-60 parts of Semen Cuscutae, 3-45 parts of ginseng, 6-36 parts of Radix Glycyrrhizae, 6-60 parts of Schisandra chinensis.However, above-mentioned Chinese medicine group
Object the disadvantages of there are complicated composition, higher cost is closed, to limit its application.
Therefore, study that novel therapeutic effect is good, toxic side effect is small, composition is simple, lower-cost raising male property function
The drug that can be acted on is of great significance.
Summary of the invention
Therefore, the present invention provide a kind of therapeutic effect is good, toxic side effect is small, composition is simple, it is lower-cost have improve
The Chinese medicine composition of male's sexual effect, and then preparation method and purposes are provided.
In order to solve the above technical problems, the present invention is achieved through the following technical solutions:
The present invention provides a kind of with the Chinese medicine composition for improving male's sexual effect, the raw material of the Chinese medicine composition
Medicine composition are as follows:
Ginseng 3-9 parts by weight, Schisandra chinensis 3-9 parts by weight, Radix Ophiopogonis 6-10 parts by weight, fructus lycii 6-10 parts by weight, Radix Salviae Miltiorrhizae 6-
12 parts by weight.
Preferably, the present invention is above-mentioned has the Chinese medicine composition for improving male's sexual effect, the Chinese medicine composition
Bulk pharmaceutical chemicals composition are as follows:
3 parts by weight of ginseng, Schisandra chinensis 6-8 parts by weight, Radix Ophiopogonis 6-7 parts by weight, fructus lycii 6-7 parts by weight, Radix Salviae Miltiorrhizae 6-7 weight
Part.
It is further preferred that the present invention is above-mentioned to have the Chinese medicine composition for improving male's sexual effect, the Chinese medicine group
Close the bulk pharmaceutical chemicals composition of object are as follows:
3 parts by weight of ginseng, 6.7 parts by weight of Schisandra chinensis, 6.6 parts by weight of Radix Ophiopogonis, 6.6 parts by weight of fructus lycii, 6 weight of Radix Salviae Miltiorrhizae
Part；Or
3 parts by weight of ginseng, 8 parts by weight of Schisandra chinensis, 7 parts by weight of Radix Ophiopogonis, 7 parts by weight of fructus lycii, 7 parts by weight of Radix Salviae Miltiorrhizae；Or
3 parts by weight of ginseng, 6 parts by weight of Schisandra chinensis, 6 parts by weight of Radix Ophiopogonis, 6 parts by weight of fructus lycii, 6 parts by weight of Radix Salviae Miltiorrhizae.
It is including following the present invention also provides the preparation method of the above-mentioned Chinese medicine composition for having and improving male's sexual effect
Step:
(1) ginseng, Schisandra chinensis, Radix Salviae Miltiorrhizae and the fructus lycii for taking selected parts by weight respectively, then add water to cook 1-3 times, every time
1-3 hours, the 8-12 times of water measured of above-mentioned raw materials medicine total weight is added every time, obtains decoction liquor A；
(2) it the Radix Ophiopogonis for taking selected parts by weight, then adds water to cook 1-3 times, it is 0.5-2 hours each, 8-12 weight is added every time
The water of amount times amount, obtains decoction liquor B；
(3) the decoction liquor A and decoction liquor B is merged, concentration staticly settles, supernatant is concentrated to give phase at 50 DEG C
The clear cream for being 1.00-1.30 to density.
Preferably, the above-mentioned preparation method with the Chinese medicine composition for improving male's sexual effect of the present invention, including with
Lower step:
(1) then ginseng, Schisandra chinensis, Radix Salviae Miltiorrhizae and the fructus lycii for taking selected parts by weight respectively add water to cook 2 times, for the first time
The 9-11 times of water measured of above-mentioned raw materials medicine total weight is added, decocts 1.5-2.5 hours, second of addition above-mentioned raw materials medicine total weight
The 9-11 times of water measured, decoct 1-2 hours, obtain decoction liquor A；
(2) Radix Ophiopogonis of selected parts by weight is taken, is then added water to cook 2 times, it is 0.5-1.5 hours each, 9-11 is added for the first time
The water of times of weight amount, the water of second of addition 7-9 times of weight amount, obtains decoction liquor B；
(3) the decoction liquor A and decoction liquor B is merged, concentration staticly settles, supernatant is concentrated to give phase at 50 DEG C
The clear cream for being 1.05-1.20 to density.
It is further preferred that the above-mentioned preparation method with the Chinese medicine composition for improving male's sexual effect of the present invention,
The following steps are included:
(1) then ginseng, Schisandra chinensis, Radix Salviae Miltiorrhizae and the fructus lycii for taking selected parts by weight respectively add water to cook 2 times, for the first time
The water of 10 times of amounts of above-mentioned raw materials medicine total weight is added, decocts 2 hours, 8 times of amounts of second of addition above-mentioned raw materials medicine total weight
Water, decoct 1.5 hours, obtain decoction liquor A；
(2) Radix Ophiopogonis of selected parts by weight is taken, then adds water to cook 2 times, 1 hour every time, 10 times of weight amounts is added for the first time
Water, second is added the water of 8 times of weight amounts, obtains decoction liquor B；
(3) the decoction liquor A and decoction liquor B is merged, concentration staticly settles, supernatant is concentrated to give phase at 50 DEG C
The clear cream for being 1.10-1.15 to density.
The present invention also provides include it is above-mentioned have improve male's sexual effect Chinese medicine composition preparation or including
The preparation for the Chinese medicine composition that above-mentioned preparation method is prepared,
The Chinese medicine composition is added customary adjuvant and clinically acceptable oral solution, particle is made according to common process
Agent, tablet, capsule, powder, pill, syrup or paste.
The customary adjuvant are as follows: filler, disintegrating agent, lubricant, suspending agent, adhesive, sweetener, corrigent, anti-corrosion
Agent, matrix etc..Filler includes: starch, pregelatinized starch, lactose, mannitol, chitin, microcrystalline cellulose, sucrose etc.；It collapses
Solving agent includes: starch, pregelatinized starch, microcrystalline cellulose, sodium carboxymethyl starch, crosslinked polyvinylpyrrolidone, low substitution hydroxyl
Third cellulose, cross-linked carboxymethyl cellulose are received；Lubricant includes: magnesium stearate, lauryl sodium sulfate, talcum powder, dioxy
SiClx etc.；Suspending agent includes: polyvinylpyrrolidone, microcrystalline cellulose, sucrose, agar, hydroxypropyl methyl cellulose etc.；Bonding
Agent includes starch slurry, polyvinylpyrrolidone, hydroxypropyl methyl cellulose etc.；Sweetener includes: saccharin sodium, aspartame, sugarcane
Sugar, honey element, enoxolone etc.；Corrigent includes: sweetener and various essence；Preservative include: parabens, benzoic acid,
Sodium benzoate, sorbic acid and its esters, benzalkonium bromide, the fixed, eucalyptus oil of acetic acid chloroethene etc.；Matrix include: PEG6000,
PEG4000, insect wax etc..
The Chinese medicine composition that is prepared the present invention also provides above-mentioned Chinese medicine composition, above-mentioned preparation method or among the above
The preparation of drug composition has the application in the drug for improving male's sexual effect in preparation.
Technical solution of the present invention has the advantages that
[ginseng] is warm-natured, flat, sweet in flavor, slight bitter；Returns spleen, lung channel, the heart channel of Hang-Shaoyin；Effect: replenish vital energy, restore pulse, and strengthen and remove vital energy, tonifying spleen benefit
Lung promotes the production of body fluid, and calms the nerves.
[Schisandra chinensis] is warm-natured, sweet in flavor, sour；Distributed in lung channel, kidney channel, the heart channel of Hang-Shaoyin；Effect: nourishing generate fluid, kidney tonifying nourishing heart, convergence are solid
It is puckery.
[Radix Ophiopogonis] cold nature is sweet in flavor, bitter；Distributed in lung channel, the heart channel of Hang-Shaoyin, stomach meridian；Effect: Yin nourishing and lung moistening, reinforcing stomach reg fluid clear away heart-fire and remove
It is tired.
[fructus lycii] property is sweet, and taste is flat；Return liver warp, kidney channel, lung channel；Effect: nourishing liver and kidney, improving eyesight, moistening lung.
[Radix Salviae Miltiorrhizae] cold nature, bitter；Thoughts of returning home warp, Liver Channel；Effect: stasis-dispelling and pain-killing, blood circulation, relieving restlessness and restlessness.
The present invention has the Chinese medicine composition for improving male's sexual effect, fully considers ginseng, Schisandra chinensis, Radix Ophiopogonis, Chinese holly
The channel tropism and nature and flavor of matrimony vine and each Chinese medicine of Radix Salviae Miltiorrhizae, and the proportion for selecting each Chinese medicine mutual, make each Chinese medicine according to " monarch, minister,
Help, make " compatibility relationship cooperate, collective effect, to act on lesion, and then play and improve male's sexual effect
Curative effect.In addition, the present invention have improve male's sexual effect Chinese medicine composition only include five kinds of Chinese medicines, composition simply,
Cost is relatively low.
Specific embodiment
Technical solution of the present invention will be clearly and completely described below, it is clear that described embodiment is this hair
Bright a part of the embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not having
Every other embodiment obtained under the premise of creative work is made, shall fall within the protection scope of the present invention.
Embodiment 1
The present embodiment has the bulk pharmaceutical chemicals composition for the Chinese medicine composition for improving male's sexual effect are as follows:
Ginseng 3g, Schisandra chinensis 6.7g, Radix Ophiopogonis 6.6g, fructus lycii 6.6g, Radix Salviae Miltiorrhizae 6g；
The preparation method of the Chinese medicine composition, comprising the following steps:
(1) then ginseng, Schisandra chinensis, Radix Salviae Miltiorrhizae and the fructus lycii for taking selected weight respectively add water to cook 2 times, add for the first time
The water for entering 10 times of amounts of above-mentioned raw materials medicine total weight, decocts 2 hours, what second of 8 times that above-mentioned raw materials medicine total weight is added was measured
Water decocts 1.5 hours, obtains decoction liquor A；
(2) Radix Ophiopogonis of selected parts by weight is taken, then adds water to cook 2 times, 1 hour every time, 10 times of weight amounts is added for the first time
Water, second is added the water of 8 times of weight amounts, obtains decoction liquor B；
(3) the decoction liquor A and decoction liquor B is merged, concentration staticly settles, supernatant is concentrated to give phase at 50 DEG C
The clear cream for being 1.10-1.15 to density.
The present embodiment has the Chinese medicine composition addition customary adjuvant for improving male's sexual effect, according to common process,
Oral solution is made.
Embodiment 2
The present embodiment has the bulk pharmaceutical chemicals composition for the Chinese medicine composition for improving male's sexual effect are as follows:
Ginseng 3g, Schisandra chinensis 8g, Radix Ophiopogonis 7g, fructus lycii 7g, Radix Salviae Miltiorrhizae 7g；
The preparation method of the Chinese medicine composition, comprising the following steps:
(1) then ginseng, Schisandra chinensis, Radix Salviae Miltiorrhizae and the fructus lycii for taking selected parts by weight respectively add water to cook 2 times, for the first time
The water of 9 times of amounts of above-mentioned raw materials medicine total weight is added, decocts 2.5 hours, 9 times of amounts of second of addition above-mentioned raw materials medicine total weight
Water, decoct 2 hours, obtain decoction liquor A；
(2) Radix Ophiopogonis of selected parts by weight is taken, then adds water to cook 2 times, 0.5 hour every time, 9 times of weight amounts is added for the first time
Water, second is added the water of 7 times of weight amounts, obtains decoction liquor B；
(3) the decoction liquor A and decoction liquor B is merged, concentration staticly settles, supernatant is concentrated to give phase at 50 DEG C
The clear cream for being 1.05-1.10 to density.
The present embodiment has the Chinese medicine composition addition customary adjuvant for improving male's sexual effect, according to common process,
Capsule is made.
Embodiment 3
The present embodiment has the bulk pharmaceutical chemicals composition for the Chinese medicine composition for improving male's sexual effect are as follows:
Ginseng 3g, Schisandra chinensis 6g, Radix Ophiopogonis 6g, fructus lycii 6g, Radix Salviae Miltiorrhizae 6g；
The preparation method of the Chinese medicine composition, comprising the following steps:
(1) then ginseng, Schisandra chinensis, Radix Salviae Miltiorrhizae and the fructus lycii for taking selected parts by weight respectively add water to cook 2 times, for the first time
The water of 11 times of amounts of above-mentioned raw materials medicine total weight is added, decocts 1.5 hours, 11 times of second of addition above-mentioned raw materials medicine total weight
The water of amount decocts 1 hour, obtains decoction liquor A；
(2) Radix Ophiopogonis of selected parts by weight is taken, then adds water to cook 2 times, 1.5 hours every time, 11 times of weight is added for the first time
The water of amount, the water of second of 9 times of weight amount of addition, obtains decoction liquor B；
(3) the decoction liquor A and decoction liquor B is merged, concentration staticly settles, supernatant is concentrated to give phase at 50 DEG C
The clear cream for being 1.10-1.20 to density.
The present embodiment has the Chinese medicine composition addition customary adjuvant for improving male's sexual effect, according to common process,
Tablet is made.
Experimental exampleThe traditional chinese medicine composition of the invention improves the research of male's sexual effect
With male mice, 25~28g of weight is random to be grouped, and experimental group 10, control group 9.
Experimental group gavage respectively the preparation of embodiment 1 oral solution (based on crude drug) 5g/kg/ days (10 times of clinical dosages,
LD50/10), one time a day；Control group gavages 0.5mL physiological saline, one time a day；Continue 24.From administration the 4th day, each group was dynamic
Object daily 25 DEG C~30 DEG C deep water middle reaches soak 3.5 hours as stress, continue three weeks.It is done being administered one week and being administered the 25th
Sexual function experiment.
Female adult mouse, 25~30g of weight.For the Oestrus rate for increasing animal, intramuscular injection female hormone diethylstilbestrol
0.4mg/kg/ days.After 2 days, vaginal smear microscopy shows to record in estrus with the seedless keratinocyte in surface layer for main person
With.This heat female mice, 5 cage packing.In 6 points of early morning, every cage adds the female mice of an experiment, in observation 5 minutes
The number of copulations and mating rate of generation.Specific experiment the results are shown in Table 1.
Influence of the table 1 to mouse sexual function
As shown in Table 1: (1) after one week of dosing, experimental group mating frequency is apparently higher than control group mating frequency, there is conspicuousness
Meaning；Experimental group mating rate is also higher than control group mating rate, but not statistically significant；(2) it is administered the 25th, control animals
Sexual function is decreased obviously, and the mating rate of test group of animals, without change, only mating frequency number is reduced；Experimental group mating frequency
It is apparently higher than control group mating frequency, there is significant；Experimental group mating rate is also higher than control group mating rate, there is conspicuousness meaning
Justice.
In conclusion the sexual function of buck can be improved in the traditional chinese medicine composition of the invention, potential raising can be used as
The drug of male's sexual.
Obviously, the above embodiments are merely examples for clarifying the description, and does not limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And it is extended from this it is obvious variation or
It changes still within the protection scope of the invention.
Claims (7)
1. a kind of with the Chinese medicine composition for improving male's sexual effect, which is characterized in that the raw material of the Chinese medicine composition
Medicine composition are as follows:
3 parts by weight of ginseng, Schisandra chinensis 6-8 parts by weight, Radix Ophiopogonis 6-7 parts by weight, fructus lycii 6-7 parts by weight, Radix Salviae Miltiorrhizae 6-7 parts by weight.
2. according to claim 1 have the Chinese medicine composition for improving male's sexual effect, which is characterized in that in described
The bulk pharmaceutical chemicals of drug composition form are as follows:
3 parts by weight of ginseng, 6.7 parts by weight of Schisandra chinensis, 6.6 parts by weight of Radix Ophiopogonis, 6.6 parts by weight of fructus lycii, 6 parts by weight of Radix Salviae Miltiorrhizae；Or
Person
3 parts by weight of ginseng, 8 parts by weight of Schisandra chinensis, 7 parts by weight of Radix Ophiopogonis, 7 parts by weight of fructus lycii, 7 parts by weight of Radix Salviae Miltiorrhizae；Or
3 parts by weight of ginseng, 6 parts by weight of Schisandra chinensis, 6 parts by weight of Radix Ophiopogonis, 6 parts by weight of fructus lycii, 6 parts by weight of Radix Salviae Miltiorrhizae.
3. a kind of preparation method with the Chinese medicine composition for improving male's sexual effect of any of claims 1 or 2, special
Sign is, comprising the following steps:
(1) ginseng, Schisandra chinensis, Radix Salviae Miltiorrhizae and the fructus lycii for taking selected parts by weight respectively, then add water to cook 1-3 times, and each 1-3 is small
When, the 8-12 times of water measured of above-mentioned raw materials medicine total weight is added every time, obtains decoction liquor A；
(2) it the Radix Ophiopogonis for taking selected parts by weight, then adds water to cook 1-3 times, it is 0.5-2 hours each, 8-12 times of weight is added every time
The water of amount obtains decoction liquor B；
(3) the decoction liquor A and decoction liquor B is merged, concentration staticly settles, supernatant is concentrated to give relatively close at 50 DEG C
Degree is the clear cream of 1.00-1.30.
4. the preparation method with the Chinese medicine composition for improving male's sexual effect according to claim 3, feature
It is, comprising the following steps:
(1) then ginseng, Schisandra chinensis, Radix Salviae Miltiorrhizae and the fructus lycii for taking selected parts by weight respectively add water to cook 2 times, be added for the first time
The 9-11 times of water measured of above-mentioned raw materials medicine total weight decocts 1.5-2.5 hours, the 9- of second of addition above-mentioned raw materials medicine total weight
The water of 11 times of amounts decocts 1-2 hours, obtains decoction liquor A；
(2) Radix Ophiopogonis of selected parts by weight is taken, is then added water to cook 2 times, it is 0.5-1.5 hours each, 9-11 weight is added for the first time
The water of amount again, the water of second of addition 7-9 times of weight amount, obtains decoction liquor B；
(3) the decoction liquor A and decoction liquor B is merged, concentration staticly settles, supernatant is concentrated to give relatively close at 50 DEG C
Degree is the clear cream of 1.05-1.20.
5. the preparation method with the Chinese medicine composition for improving male's sexual effect according to claim 4, feature
It is, comprising the following steps:
(1) then ginseng, Schisandra chinensis, Radix Salviae Miltiorrhizae and the fructus lycii for taking selected parts by weight respectively add water to cook 2 times, be added for the first time
The water of 10 times of amounts of above-mentioned raw materials medicine total weight, decocts 2 hours, the water of 8 times of amounts of second of addition above-mentioned raw materials medicine total weight,
It decocts 1.5 hours, obtains decoction liquor A；
(2) Radix Ophiopogonis of selected parts by weight is taken, then adds water to cook 2 times, 1 hour every time, the water of 10 times of weight amounts is added for the first time,
The water of second of 8 times of weight amount of addition, obtains decoction liquor B；
(3) the decoction liquor A and decoction liquor B is merged, concentration staticly settles, supernatant is concentrated to give relatively close at 50 DEG C
Degree is the clear cream of 1.10-1.15.
6. include it is of any of claims 1 or 2 have improve male's sexual effect Chinese medicine composition preparation or including
The preparation for the Chinese medicine composition that the described in any item preparation methods of claim 3-5 are prepared, which is characterized in that
Customary adjuvant is added in the Chinese medicine composition, according to common process, be made clinically acceptable oral solution, granule,
Tablet, capsule, powder, pill, syrup or paste.
7. Chinese medicine composition of any of claims 1 or 2, the described in any item preparation methods of claim 3-5 are prepared
The preparation of Chinese medicine composition or Chinese medicine composition as claimed in claim 6 has the medicine for improving male's sexual effect in preparation
Application in object.
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| CN105497495A (en) * | 2015-12-21 | 2016-04-20 | 北京同仁堂科技发展股份有限公司 | Traditional Chinese medicine composition with anti-fatigue effect and preparation method and application thereof |
| CN105535425B (en) * | 2015-12-21 | 2019-05-31 | 北京同仁堂科技发展股份有限公司 | A kind of Chinese medicine composition with strengthen immunity effect and preparation method thereof and purposes |
| CN112156075A (en) * | 2020-08-28 | 2021-01-01 | 南京康齐生物科技有限公司 | Preparation method of nervonic acid and polysaccharide composite supporting nanoparticles and application of nervonic acid and polysaccharide composite supporting nanoparticles in male health care products |
| CN113116905A (en) * | 2021-04-20 | 2021-07-16 | 北京天玺宝科技有限公司 | A composition for improving male sexual function and continuously improving sexual dysfunction, and its preparation method |
| CN116870096A (en) * | 2023-08-04 | 2023-10-13 | 北京同仁堂科技发展股份有限公司 | Application of tranquillizing and brain tonic liquid in preparing medicine for treating or preventing depression |
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