CN103656226A - Compound medicine for treating sicca syndrome - Google Patents
Compound medicine for treating sicca syndrome Download PDFInfo
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- CN103656226A CN103656226A CN201210345391.1A CN201210345391A CN103656226A CN 103656226 A CN103656226 A CN 103656226A CN 201210345391 A CN201210345391 A CN 201210345391A CN 103656226 A CN103656226 A CN 103656226A
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- atractylodis macrocephalae
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Abstract
The invention relates to a compound medicine for treating sicca syndrome and a preparation method thereof. The medicine is characterized in that Chinese medicinal herb components with reasonable compatibility are selected. The medicine is prepared from the following effective components: ophiopogon root, dangshen, rhizoma atractylodis macrocephalae, Chinese yam, schisandra fruit, tuckahoe, radix rehmanniae, testa trionidis, dendrobe, kudzu root and licorice. The medicine is prepared from pure Chinese medicinal herb components and is free of any chemical component. The Chinese medicinal herb components are strictly screened and proportioned through the experiments, so the medicine has favorable compound effect. The medicine is prepared by a special technique, has the advantages of stable quality and no toxic or side effect on the human body, is convenient to take, and is used for treating chronic inflammation autoimmune disease-sicca syndrome which mainly infringes salivary glands and lacrimal glands.
Description
technical fieldthe present invention relates to a kind of sjogren syndrome compound medicines and preparation method thereof for the treatment of.The Chinese herbal medicine composition that it is characterized in that selected reasonable compatibility.The active ingredient of formula is Radix Ophiopogonis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Fructus Schisandrae Chinensis, Poria, the Radix Rehmanniae, Carapax Trionycis, Herba Dendrobii, Radix Puerariae, Radix Glycyrrhizae, the present invention is pure medicinal herb components, not containing any chemical composition, through testing strict screening compatibility, compound recipe action effect is good, forms steady quality through special process configuration, be convenient to take, human body is had no side effect, be used for the treatment of
Take and invade salivary gland and lachrymal gland is main chronic inflammatory autoimmune disease---sjogren syndrome.
background technologysjogren syndrome is a chronic inflammation autoimmune disease of mainly involving exocrine gland.Clinically apart from salivary gland and the impaired function reduction of lachrymal gland, occur obvious dry mouth and tougue, eyes are dry and astringent, still have outer other organs of other exocrine glanies and body of gland to get involved and occur the symptom of multisystem infringement, and severe patient has lungs, liver and kidney and gets involved.At present to primary Sjogren's syndrome there is no can radical curing of disease method.Prevalence in population of China is 0.29%-0.77% with different diagnostic criterias, and in elderly population, prevalence is 3%-4%.Primary disease women is common, and men and women is than being 1:9-1:20, and age of onset is many at 40 years old-50 years old, also sees child.
The dialectical treatment of motherland's medical science can patients in remission, stop disease progression and extend patient's life cycle.Treatment sjogren syndrome compound medicines providing a kind of pure natural plant essence extraction and preparation method thereof is provided the object of the invention, has heat-clearing and toxic substances removing, spleen invigorating mind calming, qi-supplementing, blood-engendering, the effect of warming middle-JIAO to relieve pain.Because sjogren syndrome is a kind of systemic disease, the utmost point improves symptom, and controlling and delaying that internal organs get involved is to tackle the important of sjogren syndrome can obviously improve patients ' life quality.
summary of the inventionthe invention is characterized in a kind of sjogren syndrome compound medicines and preparation method thereof for the treatment of is provided, utilize the mutual synergism of active component of multiple Chinese herbal medicine essence, there is heat-clearing and toxic substances removing, spleen invigorating mind calming, qi-supplementing, blood-engendering, the effect of warming middle-JIAO to relieve pain.
Formula of the present invention following (component and percentage by weight % thereof): Radix Ophiopogonis 20.0-30.0, Radix Codonopsis 12.0-20.0, Rhizoma Atractylodis Macrocephalae 9.0-15.0, Rhizoma Dioscoreae 12.0-20.0, Fructus Schisandrae Chinensis 5.0-12.0, Poria 6.0-12.0, Radix Rehmanniae 4.0-10.0, Carapax Trionycis 15.0-30.0, Herba Dendrobii 4.0-12.0, Radix Puerariae 6.0-15.0, Radix Glycyrrhizae 2.0-6.0.
Radix Ophiopogonis, pharmacological action: 1, can strengthen reticuloendothelial system phagocytic activity Radix Ophiopogonis, rising peripheral leukocytes, strengthens immunologic function.2, can strengthen pituitary adrenal system effect, improve organism adaptation 3, can significantly improve laboratory animal hypoxia-bearing capability, increase coronary flow, myocardial ischemia be had to obvious protective effect 4, other effects: also have certain calmness and antibacterial action Radix Ophiopogonis.
Radix Codonopsis, pharmacological action: 1, enhancing human body immunity function: Radix Codonopsis extract can strengthen the ability that Turnover of Mouse Peritoneal Macrophages is engulfed chicken red blood cell.2, anti-stress effect: Radix Codonopsis can improve the resistivity of body to destructive stimulus.Radix Codonopsis polysaccharide can birth be grown mice swimming time, strengthen heat-resisting ability, strengthen adrenalectomy mice hypoxia-bearing capability.The anti-stress effect mechanism of Radix Codonopsis is main relevant with the function of excited Hypophysis-adrenal cortex axis.3 other effects: the effects such as Radix Codonopsis energy Gastrointestinal motility adjustment, antiulcer, slow down aging, anti-hypoxia, radioprotective.
The Rhizoma Atractylodis Macrocephalae, is described as " spleen air making-up and spleen enlivening the first key medicine " by forefathers.Pharmacological action: 1, activity has dual regulation to the Rhizoma Atractylodis Macrocephalae to intestinal tube, has the effect of control Experimental Gastric Ucler.2, strong effect, can promote Mouse Weight to increase, and can obviously promote the synthetic of Protein in small intestine.3 other effects: can promote cellular immune function, have and necessarily put forward effect in increasing leukocyte, can also protect the liver, function of gallbladder promoting, diuresis, blood sugar lowering, anticoagulant, antibacterial, antitumor.
Rhizoma Dioscoreae, pharmacological action: 1, immunological enhancement: Rhizoma Dioscoreae has preventive and therapeutic action to experimental rat model of spleen deficiency, and isolated intestinal motility is had to dual regulation, has digestion-aid effect.2, other effects: the effects such as blood sugar lowering, antioxidation.
Fructus Schisandrae Chinensis, pharmacological action: 1, increase cellular immune function: make brain, liver, the active obviously enhancing of spleen SOD, therefore there is the immunity of raising, antioxidation, anti-aging effects.2, nervous system maincenters at different levels are all had to excitation, corticocerebral excitement and process of inhibition are all had to impact, make it to tend to balance.3, anti-stress effect: can the defence capability of enhancing body to nonspecific stimulation.
Poria, pharmacological action: 1, strengthen immunologic function: pachyman has potentiation to the immunologic function of mice, can strengthen macrophage phagocytosis of mice.2, hepatoprotective effect: Poria has significant protective effect to the caused mouse liver injury of carbon tetrachloride, can make gpt activity obviously reduce, and prevents hepatic necrosis.3, other effects: Poria decoct, syrup, alcohol extract, ether extract, have respectively the effect of diuresis, calmness, antitumor, blood sugar lowering, increase myocardial contraction.
Radix Rehmanniae pharmacological action: 1, the Radix Rehmanniae has the effect that promotes the lymphoblastic conversion of body, increases T lymphocyte quantity, and can strengthen the phagocytic function of reticuloendothelial cell, more obvious to immunologic hypofunction person effect especially.2, Radix Rehmanniae aqueous extract has blood pressure lowering, calmness, antiinflammatory, anti-allergic effects.
Carapax Trionycis pharmacological action: 1, strengthen immunologic function: Carapax Trionycis can reduce experimental hyperthyroidism animal cAMP content, heightens lymphoblastic transformation rate, extend antibody life period.2, can promote hemopoietic function, improve content of hemoglobin.3, can protect adrenal cortex function, prevent cell mutation effect, also have certain calm effect.
Herba Dendrobii pharmacological action: 1, adjustable height mouse macrophage phagocytosis, suppress the immunologic function of mice with hydrocortisone after, dendrobium polysaccharide can recover immune function of mice.2, Herba Dendrobii can promote the secretion of gastric juice and be aid digestion, makes its hyperperistalsis and relieving constipation.3, Herba Dendrobii has certain Analgesic And Antipyretic Effects, and its effect is similar to Phenacetin and.
Radix Puerariae pharmacological action: 1, the effect to blood circulation: the flavone proposing in Radix Puerariae can increase brain and crown vascular flow amount.2, improve hepatocellular regeneration capacity, recover normal liver function, promote bile secretion, prevent that fat from piling up at liver.3, enhance metabolism, strengthen liver detoxification function, prevent the damage of ethanol to liver.
Radix Glycyrrhizae pharmacological action: 1, adrenocortical hormone sample effect: Radix Glycyrrhizae extractum, glycyrrhizin and enoxolone have promotion sodium to Healthy People and animal, the effect of water retention, low dose of glycyrrhizin can make rat chest gland atrophy and adrenal gland's weight increase, and produces the effect of glucocorticoid cortisone sample.When heavy dose of, the effect of glucocorticoid sample is not obvious, only presents the effect of mineralocorticoid sample.2, regulate body's immunity, arrhythmia.
The preparation method of product of the present invention:
1) Radix Ophiopogonis, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Dioscoreae, Fructus Schisandrae Chinensis, Poria, the Radix Rehmanniae, Carapax Trionycis, Herba Dendrobii, Radix Puerariae, Radix Glycyrrhizae, through grinding, soaks one hour;
2), after big fire is heated to boiling, from boiling 30 minutes, leach the head liquid of boiling medicine;
3) add again clear water, continue slow fire and decoct, repeat 2) step 2 ~ 3 time; Leach the liquid of boiling medicine again;
4) Chinese herbal medicine fluid leaching is mixed, 2000 revs/min are carried out centrifugally, extract the medicinal liquid of supernatant;
5) cooling, take the dish out of the pot, subpackage, high temperature sterilize, the warehouse-in that is up to the standards is standby.
The present invention has the following advantages:
(1) refine pure natural plant Chinese herbal medicine elite composition, nontoxic to human body;
(2) screen the multiple natural vegetable Chinese herbal medicine elite with nourishing YIN and clearing away heat, supplementing QI for promoting the production of body fluid, the astringent or styptic treatment for spontaneous sweating effect of convergence, can effectively alleviate each systemic symptom of whole body that sjogren syndrome causes;
(3) can improve Patients with Sjogren Syndrome immunity, to improving the treatment of exocrine gland function, play the effect of auxiliary treatment;
(4) can reduce sjogren syndrome patient's misery, improve the quality of living.
the specific embodiment:the present invention is described in further detail in conjunction with the embodiments for face:
According to following table institute column data (percentage by weight %) and described step thereof, be configured:
Formula one:
Radix Ophiopogonis 20.0-30.0
Radix Codonopsis 12.0-20.0
Rhizoma Atractylodis Macrocephalae (parched) 9.0-15.0
Rhizoma Dioscoreae 12.0-20.0
Fructus Schisandrae Chinensis 5.0-12.0
Poria 6.0-12.0
Radix Rehmanniae 4.0-10.0
Carapax Trionycis 15.0-30.0
Herba Dendrobii 4.0-12.0
Radix Puerariae 6.0-15.0
Radix Glycyrrhizae 2.0-6.0
Water to 100.0
Formula two:
Radix Ophiopogonis 22.0-30.0
Radix Codonopsis 15.0-20.0
Rhizoma Atractylodis Macrocephalae (parched) 11.0-15.0
Rhizoma Dioscoreae 13.0-20.0
Fructus Schisandrae Chinensis 7.0-12.0
Poria 9.0-12.0
Radix Rehmanniae 6.0-10.0
Carapax Trionycis 18.0-30.0
Herba Dendrobii 6.0-12.0
Radix Puerariae 9.0-15.0
Radix Glycyrrhizae 3.0-6.0
Water to 100.0
____________________________________________________________________
Formula three:
Radix Ophiopogonis 22.0-38.0
Radix Codonopsis 15.0-18.0
Rhizoma Atractylodis Macrocephalae (parched) 11.0-14.0
Rhizoma Dioscoreae 13.0-18.0
Fructus Schisandrae Chinensis 7.0-11.0
Poria 9.0-10.0
Radix Rehmanniae 6.0-9.0
Carapax Trionycis 18.0-25.0
Herba Dendrobii 6.0-10.0
Radix Puerariae 9.0-12.0
Radix Glycyrrhizae 3.0-5.0
Water to 100.0
Claims (2)
1. the present invention relates to a kind of sjogren syndrome compound medicines for the treatment of, it is characterized in that thering is following formula (component and percentage by weight % thereof): Radix Ophiopogonis 20.0-30.0, Radix Codonopsis 12.0-20.0, Rhizoma Atractylodis Macrocephalae 9.0-15.0, Rhizoma Dioscoreae 12.0-20.0, Fructus Schisandrae Chinensis 5.0-12.0, Poria 6.0-12.0, Radix Rehmanniae 4.0-10.0, Carapax Trionycis 15.0-30.0, Herba Dendrobii 4.0-12.0, Radix Puerariae 6.0-15.0, Radix Glycyrrhizae 2.0-6.0.
2. described in claim 1, treat a sjogren syndrome compound medicines, it is characterized in that having following technique:
1) Radix Ophiopogonis, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Dioscoreae, Fructus Schisandrae Chinensis, Poria, the Radix Rehmanniae, Carapax Trionycis, Herba Dendrobii, Radix Puerariae, Radix Glycyrrhizae, through grinding, soaks one hour;
2), after big fire is heated to boiling, from boiling 30 minutes, leach the head liquid of boiling medicine;
3) add again clear water, continue slow fire and decoct, repeat 2) step 2 ~ 3 time; Leach the liquid of boiling medicine again;
4) Chinese herbal medicine fluid leaching is mixed, 2000 revs/min are carried out centrifugally, extract the medicinal liquid of supernatant;
5) cooling, take the dish out of the pot, subpackage, high temperature sterilize, the warehouse-in that is up to the standards is standby.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104547502A (en) * | 2015-01-31 | 2015-04-29 | 河南中医学院 | Traditional Chinese medicine composition for treating sicca syndrome |
CN105031496A (en) * | 2015-08-14 | 2015-11-11 | 青岛琴诚医药技术有限公司 | Pharmaceutical preparation for curing xerostomia syndrome |
CN107669889A (en) * | 2017-09-28 | 2018-02-09 | 北京中医药大学 | Treat pharmaceutical composition of Sjogren syndrome and its production and use |
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2012
- 2012-09-18 CN CN201210345391.1A patent/CN103656226A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104547502A (en) * | 2015-01-31 | 2015-04-29 | 河南中医学院 | Traditional Chinese medicine composition for treating sicca syndrome |
CN104547502B (en) * | 2015-01-31 | 2017-09-01 | 河南中医学院 | A kind of Chinese medicine composition for treating Sjogren syndrome |
CN105031496A (en) * | 2015-08-14 | 2015-11-11 | 青岛琴诚医药技术有限公司 | Pharmaceutical preparation for curing xerostomia syndrome |
CN107669889A (en) * | 2017-09-28 | 2018-02-09 | 北京中医药大学 | Treat pharmaceutical composition of Sjogren syndrome and its production and use |
CN107669889B (en) * | 2017-09-28 | 2020-08-04 | 北京中医药大学 | Pharmaceutical composition for treating sicca syndrome and preparation method and application thereof |
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Application publication date: 20140326 |