CN103417669B - Drug for treatment of abdominal pain and diarrhea - Google Patents
Drug for treatment of abdominal pain and diarrhea Download PDFInfo
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- CN103417669B CN103417669B CN201310361987.5A CN201310361987A CN103417669B CN 103417669 B CN103417669 B CN 103417669B CN 201310361987 A CN201310361987 A CN 201310361987A CN 103417669 B CN103417669 B CN 103417669B
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Abstract
The invention discloses drug for the treatment of abdominal pain and diarrhea and belongs to the field of TCM. The drug comprises pharmaceutical effective ingredients, including Chinese granesbill, turtle shell, Eryngium foetidum herb, multibract raspberry root, cutch, birch bark, radish seed, Asiatic pennywort herb, common turczaninowia herb, Russian olive fruit, purple flower holly leaf, coastal heritiera seed, chalk, cucubalus root, Yunnan Pistache leaf, and quince. The drug has the effects of regulating qi to alleviate pain, clearing away heat and eliminating dampness, soothing the liver to dispel melancholy and tonifying the spleen to cure diarrhea, and has the significant effect of the diarrhea, watery stool, abdominal pain and poor appetite caused by damp-heat accumulation and the viral enteritis and non-infectious diarrhea caused by rotavirus. The drug has the advantages that the preparation process is simple, curative effect is good and fast, the drug is convenient to take and available for treating both symptoms and root causes, and the drug is neutral in property and has no toxic and side effects; the drug has good effects for the treatment of inappetence, nausea and vomiting, abdominal distension and diarrhea, and dyspepsia.
Description
Affiliated technical field
The present invention relates to the field of Chinese medicines, relate in particular to a kind of medicine for the treatment of stomachache, diarrhoea.
Background technology
In a lot of human eyes, stomachache, diarrhoea, as cold, fever, are a kind of indispositions, and according to World Health Organization's statistics, the annual number of the infected in the whole world reaches 1,400,000,000 person-times more than, although stomachache, diarrhoea are very common, do not equal minor issue.Investigation shows, developing country is every year because acute abdominal pain, the dead number of suffering from diarrhoea reach 10,000,000.In China, there are every year 8.36 hundred million person-times to suffer from stomachache, diarrhoea, wherein, child and old people's proportion are very high, under such situation, make doctor worry most, and a lot of patients often disorderly take medicine by rule of thumb, especially abuse of antibiotics.Defecate every day more than three times, and be loose stool, be referred to as diarrhoea, be commonly called as " diarrhoea ".Stomachache, diarrhoeal diseases account for the major part of infectious disease, be the season occurred frequently of stomachache, diarrhoeal diseases summer, the dysentery of Beijing area, concentrate and betide June 25 to JIUYUE 12 days, now will watch out for especially toxic type bacillary dysentery, toxic type bacillary dysentery change of illness state is fast, break with tremendous force, as rescued not in time, be in peril of one's life, from morbidity to death a few hours the most only.
Stomachache refers to from the pain to the above part of groin below rib.The pathological changes of the outer internal organs of intraperitoneal that cause due to a variety of causes, and show as the pain of abdominal part, stomachache may be gastro-intestinal digestion organ liver, gallbladder, pancreatic diseases, gynaecopathia or urogenital organ's defect.Stomachache is divided into acute and chronic two classes, and the cause of disease is complexity very, comprise inflammation, tumor, hemorrhage, block, the acute abdominal pain such as perforation, wound and dysfunction claims again acute abdomen, acute abdomen have change many, develop fast feature, once delay diagnosis, can cause serious consequence, even causes death.Western medical treatment generally can only be treated for a certain symptom, although this therapy takes effect obviously, also can only solve temporary transient problem, cannot reach the effect of radical cure.
Suffer from diarrhoea not strange for us, everyone lives through this disease substantially for we.Diarrhoea refers to that intestinal tube wriggling speeds and causes that defecation frequency increases, and Symptoms has stomachache flatulence, pain or disappearance after exhaust defecation, loose stool and firmly just alternately appearance.The traditional Chinese medical science will feel cold with abdominal part, and extremity are not warm, not cold resistant stimulate and at day suffer from abdominal pain and rush down be called spleen-kidney vacuity cold diarrhoea; Will be with having no appetite, dyspepsia, abdominal distention also has sagging sense, and the heavy unable deficiency of spleen-QI and stomach-QI that is called of extremity is suffered from diarrhoea; Disgruntled spirit i.e. pain is rushed down, and the liver-yang hyperactivity gram spleen that is called that rushes down rear pain relief is suffered from diarrhoea.
At present, the most effectual way for the treatment of stomachache, diarrhoea is treatment by Chinese herbs, and western medicine can only take stopgap measures and can not effect a permanent cure; Stomachache, diarrhoea may cause a series of complication, because the patient who suffers from stomachache, diarrhoea is old people or child mostly, therefore bring very large psychological burden and financial burden to household.
Summary of the invention
Medicine of the present invention has effect of regulating QI to relieve pain, clearing away heat and eliminating dampness, soothing liver-QI for relieving depression, invigorating the spleen to arrest diarrhea, to having loose bowels of causing for the treatment of retention of damp-heat in the interior, disease is seen watery stool, stomachache, poor appetite and rotavirus cause viral enteritis and noninfectious diarrhea have significant curative effect.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a medicine for stomachache, diarrhoea, raw material composition and the parts by weight of making described effective ingredient are:
55～80 parts of 59～85 parts of Radix Rubi Multibracteatis of 60～85 parts of thorn corianders of 65～90 parts of Carapax Trionycis of Geranium strictipes R. Kunth
45～66 parts of 47～70 parts of Herba Centellaes of 50～75 parts of Semen Raphanis of 51～78 parts of Cortex betulae platyphyllaes of catechu
40～53 parts of 40～60 portions of Heritiera littoralis Aites of 42～61 parts of Ilex purpurea Hassk.[I.chinensis Sims of 45～65 portions of Fructus Elaeagni Angustifoliaes of Herba Turczaninowiae Fastigiatae
20～40 parts of 32～49 parts of purple oil wood 30～45 Fen Fructus cydoniae oblongae of 35～50 parts of Radix Cucubalis of Chalk.
Raw material composition and the parts by weight of making described effective ingredient are:
60～77 parts of 61～80 parts of Radix Rubi Multibracteatis of 65～81 parts of thorn corianders of 70～85 parts of Carapax Trionycis of Geranium strictipes R. Kunth
49～63 parts of 50～67 parts of Herba Centellaes of 54～70 parts of Semen Raphanis of 55～75 parts of Cortex betulae platyphyllaes of catechu
42～50 parts of 43～55 portions of Heritiera littoralis Aites of 45～58 parts of Ilex purpurea Hassk.[I.chinensis Sims of 48～60 portions of Fructus Elaeagni Angustifoliaes of Herba Turczaninowiae Fastigiatae
23～37 parts of 35～45 parts of purple oil wood 33～40 Fen Fructus cydoniae oblongae of 38～47 parts of Radix Cucubalis of Chalk.
Raw material composition and the parts by weight of making described effective ingredient are:
63～73 parts of 65～75 parts of Radix Rubi Multibracteatis of 70～76 parts of thorn corianders of 75～80 parts of Carapax Trionycis of Geranium strictipes R. Kunth
53～60 parts of 55～65 parts of Herba Centellaes of 57～65 parts of Semen Raphanis of 60～70 parts of Cortex betulae platyphyllaes of catechu
44～47 parts of 45～50 portions of Heritiera littoralis Aites of 48～55 parts of Ilex purpurea Hassk.[I.chinensis Sims of 50～56 portions of Fructus Elaeagni Angustifoliaes of Herba Turczaninowiae Fastigiatae
25～32 parts of 38～42 parts of purple oil wood 35～37 Fen Fructus cydoniae oblongae of 40～45 parts of Radix Cucubalis of Chalk.
Raw material composition and the parts by weight of making described effective ingredient are:
68 parts of 70 parts of Radix Rubi Multibracteatis of 73 parts of thorn corianders of 78 parts of Carapax Trionycis of Geranium strictipes R. Kunth
57 parts of 60 parts of Herba Centellaes of 61 parts of Semen Raphanis of 65 parts of Cortex betulae platyphyllaes of catechu
45 parts of 48 portions of Heritiera littoralis Aites of 51 parts of Ilex purpurea Hassk.[I.chinensis Sims of 53 portions of Fructus Elaeagni Angustifoliaes of Herba Turczaninowiae Fastigiatae
28 parts of 40 parts of wooden 36 Fen Fructus cydoniae oblongae of purple oil of 43 parts of Radix Cucubalis of Chalk.
A preparation method for the treatment of the medicine of stomachache, diarrhoea, comprises following processing step:
(1) Radix Rubi Multibracteati, catechu, Semen Raphani, Herba Turczaninowiae Fastigiatae, Fructus Elaeagni Angustifoliae, Ilex purpurea Hassk.[I.chinensis Sims, Heritiera littoralis Ait, Radix Cucubali and purple oil wood are cleaned, put into container, add the distilled water of 8～12 times of amounts, soak after 4～5 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 50 DEG C, relative density is 1.10～1.14, for subsequent use;
(2) will sting coriander, Herba Centellae and clean, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(3) Carapax Trionycis is cleaned, dried, slow fire is fried, and fries to 30～50 minutes, takes out, and grinds into powder, crosses 120 order fine powders, for subsequent use;
(4) by Geranium strictipes R. Kunth with Fructus cydoniae oblongae is cleaned, immerse 80% alcohol solution dipping 1-2 hour of 6 times of amounts, reflux, extract, 1 hour, filters, by the thick paste of relative density 1.20～1.25 under 60 DEG C of environment of filtrate simmer down to, for subsequent use;
(5) Cortex betulae platyphyllae and Chalk are mixed, after mix homogeneously, carry out pulverization process, grind into powder, cross 200 order fine powders, for subsequent use;
(6) thick paste made above-mentioned steps (1)～(5), juice and fine powder are mixed, add adjuvant, utilize modern advanced pharmacy science and technology, make tablet, both treatment stomachache of the present invention, the medicine of suffering from diarrhoea.
The property of medicine of the present invention's Chinese medicine used is as follows:
Geranium strictipes R. Kunth: hardship, puckery, be slightly cold; Return liver, spleen, stomach, urinary bladder channel.Clearing away heat-damp and promoting diuresis, cooling blood for hemostasis.Main having loose bowels, dysentery, dyspepsia, gastral cavity abdomen, epistaxis, has blood in stool, menorrhagia, postpartum hemorrhage is more than, traumatic injury." choosing of Yunnan Chinese herbal medicine " carries: " astringing to arrest bleeding, invigorates blood circulation, pain relieving, stomach invigorating antidiarrheal.Control enteritis, dysentery, chronic gastritis, diarrhoea, dyspepsia, menoxenia, puerperal hemorrhage is more than, epistaxis, traumatic injury impairment caused by overstrain.”
Carapax Trionycis: salty, be slightly cold; Return liver, kidney channel.Nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, brings down a fever except steaming.For fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, stirring-up of pathogenic wind in the interior resulting from deficiency, amenorrhea ， WEIJIA, chronic malaria malaria with splenomegaly." detailed outline " carries: " except old malaria malaria with splenomegaly, insidious stomachache, recurrence caused by overexertion, relapse due to improper diet, speckle cellulitis restlessness and dyspnea, married woman's difficult labour, puerperal prolapse of the uterus, husband's erosion of vulva, stranguria caused by urinary stone; Hold back routed carbuncle.”
Thorn coriander: pungent, micro-hardship, temperature.Dispelling wind is antipyretic, stomach invigorating.For flu, measles is caved in, tracheitis, enteritis, diarrhoea, acute infectious hepatitis; Treating swelling and pain by traumatic injury is controlled in external.
Radix Rubi Multibracteati: hardship, cool.Heat-clearing and toxic substances removing, expelling wind and removing dampness, removing heat from blood, hemostasis, synthetism.Control dysentery, diarrhoea, rheumatic arthralgia, hemoptysis, women's vicarious menstruation, fracture.
Catechu: bitter, puckery, be slightly cold.Removing heat-phlegm, sore hemostasis.For cough due to lung-heat, spitting of blood, diarrhoea, infantile dyspepsia; External is controlled skin infection and is not closed up for a long time, skin eczema, aphtha, tonsillitis.
Cortex betulae platyphyllae: hardship, property is flat; Return lung, stomach, large intestine channel.Clearing away heat-damp and promoting diuresis, expelling phlegm for arresting cough, removing toxic substances.Main pharyngalgia sore throat, cough and asthma, jaundice, diarrhoea, dysentery, stranguria, dysuria, acute mastitis, sore, prurigo." Jilin Chinese herbal medicine " carries: " removing toxic substances, controls carbuncle pyogenic infections from tumour or sore, dysentery.”
Semen Raphani: pungent, sweet, flat; Return lung, spleen, stomach warp.The de-swelling that helps digestion, lowering the adverse-rising QI to resolve phlegm.For retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough." detailed outline " carries: " therapeutic method to keep the adverse QI flowing downwards Dingchuan, controls expectorant, helps digestion, and de-swelling, sharp defecation, only pain due to disorder of QI, heavy after dysentery, send out skin ulcer rash.”
Herba Centellae: bitter, acrid, cold; Return liver,spleen,kidney warp.Clearing away heat-damp and promoting diuresis, promoting blood circulation and hemostasis, removing toxic substances and promoting subsidence of swelling.Main heating, cough with asthma, laryngopharynx swelling and pain, intestinal is for being, dysentery, jaundice due to damp-heat, edema, stranguria, hematuria, epistaxis, dysmenorrhea, metrorrhagia, erysipelas, scrofula, close pyogenic infections from tumour or sore, herpes zoster, treating swelling and pain by traumatic injury, traumatic hemorrhage, snake bite and insect sting.
Herba Turczaninowiae Fastigiatae: acrid in the mouth, warm in nature.Warming the lung for resolving phlegm, invigorating spleen to remove dampness.Main cough and asthma, dysentery, oliguria is puckery." not Lu " carries: " treat lung and hinder cough with dyspnea, perspire, tremble with fear for a long time at bladder, distention and fullness, the food morbidity at night of drinking.”
Fructus Elaeagni Angustifoliae: sour in the mouth, micro-sweet, cool in nature; Return lung, liver, spleen, stomach, kidney channel.Liver-nourishing kidney-boosting, spleen invigorating regulating menstruation.Main deficiency of the liver is dizzy, lumbago due to renal deficiency, insufficiency of the spleen diarrhoea, dyspepsia, leukorrhagia, menoxenia." Chinese Herbal Medicine in Xinjiang handbook " carries: " strong, calmness, controlling nocturnal emission with astringent drugs, stomach invigorating, antidiarrheal, regulating menstruation, diuresis.Treat for stomachache, diarrhoea, physical weakness, cough due to lung-heat.”
Ilex purpurea Hassk.[I.chinensis Sims: hardship, cold.Heat-clearing and toxic substances removing, promoting blood circulation and hemostasis.For upper respiratory tract infection, chronic tracheitis, pyelonephritis, bacillary dysentery; Burn and scald is controlled in external, ulcer of the lower limb, and leprelcosis, extra earning is hemorrhage, cold injury, mastitis, chapped skin.
Heritiera littoralis Ait: sweet, puckery, flat; Return large intestine channel.Relieving diarrhea with astringents, main diarrhoea, dysentery." Xinhua's book on Chinese herbal medicine " carries: " seed is for diarrhoea, dysentery.Twig can be made toothbrush, because it is containing tannin, useful to gingiva.”
Chalk: hardship, temperature, nontoxic; Return spleen, lung, kidney channel.Warming middle-JIAO warming the kidney, astringing intestine to stop diarrhea, hemostasis, sore.Main regurgitation, dysentery, man's seminal emission, woman's menoxenia, infertile, spit blood, have blood in stool, epistaxis, marginal blepharitis, ecthyma, miliaria pruritus." medical center bun will " carries: " the raw gold of tonifying the lung, clearing away summer-heat quenches one's thirst.Control lung abscess, flaccidity, only dysentery with red and white feces, and taste, controls abdominal pain due to acute vomiting and diarrhea.”
Radix Cucubali: sweet, hardship, property is flat; Return liver, spleen channel.Blood circulation promoting and blood stasis dispelling, treating stranguria let out turbid, removing toxic substances and promoting subsidence of swelling.Main dysmenorrhea due to blood stasis, amenorrhea, vicarious menstruation, lump in the abdomen caking, pyretic stranguria, stranguria with blood, nebulousurine, leucorrhea, arthralgia pain enters network, passages through which vital energy circulates contracture, traumatic injury, carbuncle sore tumefacting virus, tonsillitis, diphtheria." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " tonifying liver, removing blood stasis with potent drugs piece, removing heat from blood heat.Control a moon amenorrhea, wet stomachache, straw mat consumptive disease, virgin regurgitant mentstrcuation, is defeated in battle, vomits, spits blood, red collapsing, leucorrhea, urgent micturition is dripping, cold-damp gas bones and muscles pain, strong muscle relaxing muscles and tendons, attacks carbuncle sore pyretic toxicity redness, mumps, tonsillitis, the red white turbid urine of man's stranguria with blood, married woman's leucorrhea with red and white discharge.Relaxing muscles and tendons and removing obstructionfrom meridians, removing blood stasis.Loose scrofula tuberculosis, attacks swollen ulcer drug red hard, and the pus that has of clothes is lifted one's head, and no pus stands and disappears.”
Purple oil wood: bitter, puckery, cool.Heat-clearing and toxic substances removing, astringing to arrest bleeding.Cure mainly dysentery, enteritis, diarrhoea, traumatic hemorrhage, skin infection eczema.
Fructus cydoniae oblongae: sweet, sour, temperature.Damp eliminating expelling summer-heat, relaxing muscles and tendons and activating QI and blood in the collateral.For Sunstroke, vomiting, diarrhoea, dyspepsia, arthralgia, sural spasm." Kaibao Bencao " carries: " main warming the middle warmer and descending qi, helps digestion, and removes vinegar water in the heart, deodorizes.”
The present invention compared with prior art, has following beneficial effect:
1, medicine of the present invention has effect of regulating QI to relieve pain, clearing away heat and eliminating dampness, soothing liver-QI for relieving depression, invigorating the spleen to arrest diarrhea, to having loose bowels of causing for the treatment of retention of damp-heat in the interior, that disease is seen watery stool, stomachache, poor appetite and rotavirus cause is viral
Enteritis and noninfectious diarrhea have significant curative effect.
2, medicine of the present invention has advantages of that preparing process is easy, good effect, instant effect, taking convenience, treating both the principal and secondary aspects of a disease, the property of medicine are gentle, have no side effect, and treatment inappetence, nausea and vomiting, abdominal distention diarrhoea, dyspepsia are had to good effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
Raw material composition and the weight of effective ingredient of the present invention are:
Geranium strictipes R. Kunth 85g Carapax Trionycis 81g thorn coriander 80g Radix Rubi Multibracteati 77g
Catechu 75g Cortex betulae platyphyllae 70g Semen Raphani 67g Herba Centellae 63g
Herba Turczaninowiae Fastigiatae 60g Fructus Elaeagni Angustifoliae 58g Ilex purpurea Hassk.[I.chinensis Sims 55g Heritiera littoralis Ait 50g
The purple oily wooden 40g Fructus cydoniae oblongae 37g of Chalk 47g Radix Cucubali 45g.
A preparation method for the treatment of the medicine of stomachache, diarrhoea, comprises following processing step:
(1) Radix Rubi Multibracteati, catechu, Semen Raphani, Herba Turczaninowiae Fastigiatae, Fructus Elaeagni Angustifoliae, Ilex purpurea Hassk.[I.chinensis Sims, Heritiera littoralis Ait, Radix Cucubali and purple oil wood are cleaned, put into container, add the distilled water of 8～12 times of amounts, soak after 4～5 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 50 DEG C, relative density is 1.10～1.14, for subsequent use;
(2) will sting coriander, Herba Centellae and clean, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(3) Carapax Trionycis is cleaned, dried, slow fire is fried, and fries to 30～50 minutes, takes out, and grinds into powder, crosses 120 order fine powders, for subsequent use;
(4) by Geranium strictipes R. Kunth with Fructus cydoniae oblongae is cleaned, immerse 80% alcohol solution dipping 1-2 hour of 6 times of amounts, reflux, extract, 1 hour, filters, by the thick paste of relative density 1.20～1.25 under 60 DEG C of environment of filtrate simmer down to, for subsequent use;
(5) Cortex betulae platyphyllae and Chalk are mixed, after mix homogeneously, carry out pulverization process, grind into powder, cross 200 order fine powders, for subsequent use;
(6) thick paste made above-mentioned steps (1)～(5), juice and fine powder are mixed, add adjuvant, utilize modern advanced pharmacy science and technology, make tablet, both treatment stomachache of the present invention, the medicine of suffering from diarrhoea.
Usage and dosage: oral, every day 3 times, each 2; Within 4 days, be 1 course for the treatment of, take effect common 1 course for the treatment of, 2～3 recoveries from illness course for the treatment of.
Embodiment 2
Raw material composition and the weight of effective ingredient of the present invention are:
Geranium strictipes R. Kunth 80g Carapax Trionycis 76g thorn coriander 75g Radix Rubi Multibracteati 73g
Catechu 70g Cortex betulae platyphyllae 65g Semen Raphani 65g Herba Centellae 60g
Herba Turczaninowiae Fastigiatae 56g Fructus Elaeagni Angustifoliae 55g Ilex purpurea Hassk.[I.chinensis Sims 50g Heritiera littoralis Ait 47g
The purple oily wooden 37g Fructus cydoniae oblongae 32g of Chalk 45g Radix Cucubali 42g.
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
Raw material composition and the weight of effective ingredient of the present invention are:
Geranium strictipes R. Kunth 78g Carapax Trionycis 73g thorn coriander 70g Radix Rubi Multibracteati 68g
Catechu 65g Cortex betulae platyphyllae 61g Semen Raphani 60g Herba Centellae 57g
Herba Turczaninowiae Fastigiatae 53g Fructus Elaeagni Angustifoliae 51g Ilex purpurea Hassk.[I.chinensis Sims 48g Heritiera littoralis Ait 45g
The purple oily wooden 36g Fructus cydoniae oblongae 28g of Chalk 43g Radix Cucubali 40g.
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 4
Raw material composition and the weight of effective ingredient of the present invention are:
Geranium strictipes R. Kunth 75g Carapax Trionycis 70g thorn coriander 65g Radix Rubi Multibracteati 63g
Catechu 60g Cortex betulae platyphyllae 57g Semen Raphani 55g Herba Centellae 53g
Herba Turczaninowiae Fastigiatae 50g Fructus Elaeagni Angustifoliae 48g Ilex purpurea Hassk.[I.chinensis Sims 45g Heritiera littoralis Ait 44g
The purple oily wooden 35g Fructus cydoniae oblongae 25g of Chalk 40g Radix Cucubali 38g.
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 5
Raw material composition and the weight of effective ingredient of the present invention are:
Geranium strictipes R. Kunth 70g Carapax Trionycis 65g thorn coriander 61g Radix Rubi Multibracteati 60g
Catechu 55g Cortex betulae platyphyllae 54g Semen Raphani 50g Herba Centellae 49g
Herba Turczaninowiae Fastigiatae 48g Fructus Elaeagni Angustifoliae 45g Ilex purpurea Hassk.[I.chinensis Sims 43g Heritiera littoralis Ait 42g
The purple oily wooden 33g Fructus cydoniae oblongae 23g of Chalk 38g Radix Cucubali 35g.
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Clinical data:
1, case selection:
As the medicine for the treatment of stomachache, diarrhoea, select stomachache, the routine clinical observation of diarrhea patient 600 of making a definite diagnosis.
Patient is divided into two groups for the treatment of first group and contrast second groups at random, treatment first group 300 examples, wherein male's 157 examples, women's 143 examples, 11～70 years old age, 35.6 years old mean age, the shortest person of the course of disease 5 days, elder 1 month, average 12 days.Contrast second group 300 examples, wherein male's 156 examples, women's 144 examples, 12～72 years old age, 34.5 years old mean age, the shortest person of the course of disease 4 days, elder 1 month, average 11 days.The course of disease, the degrees of symptoms for the treatment of first group and two groups of cases of contrast second group are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment first group is taken medicine of the present invention, oral, every day 3 times, each 2; Within 4 days, be 1 course for the treatment of, take effect common 1 course for the treatment of, 2～3 recoveries from illness course for the treatment of.
Contrast second group is taken norfloxacin capsule, a 400mg, and 2 times on the one, the suitable (medicine) being taken before meal use of this product, and the 250ml that simultaneously drinks water, 5 days be 1 course for the treatment of, and take effect 2～3 courses for the treatment of, and the person of being in a bad way is conventionally invalid.
3, efficacy determination:
(1) cure: by treating rear stomachache, symptom of diarrhea disappears completely, it is normal that functional activity recovers, and do not recur again.
(2) effective: by treating rear stomachache, symptom of diarrhea disappears substantially.
(3) effective: by treating rear stomachache, symptom of diarrhea disappearance or alleviating, even after 1 month have recurrence or increase the weight of.
(4) invalid: by treating rear stomachache, diarrhoea without any alleviation, symptom is as front.
4, result:
Select in the treatment first group of medicine of the present invention, cure 113 examples, effective 98 examples, effective 85 examples, invalid 4 examples, cure rate 37.7%, total effective rate 98.7%.
In contrast second group, cure 75 examples, effective 56 examples, effective 43 examples, invalid 126 examples, cure rate 25%, total effective rate 58%.
Above result demonstration, the cure rate for the treatment of first group and total effective rate are apparently higher than contrast second group.
Model case is given an example:
1, Zhang, man, 67 years old, people from Shenyang, Liaoning, showed as epigastric discomfort, pain, anorexia and feels sick, vomits.Take 1 course for the treatment of of medicine of the present invention, symptom disappears substantially, continues to take 1 course for the treatment of, and stomachache completely disappears and do not recur again, cures.
2, Guo, female, 54 years old, people from Datong, have loose bowels three or four nearly two week every day, and abdominal distention stomachache, with low grade fever.Be diagnosed as diarrhoea, take medicine of the present invention, the morning, noon and afternoon respectively once, each 2, observe after treating two courses for the treatment of, stool is normal, described transference cure.
3, Lee, man, 42 years old, people from Baoding, treats not in time because of dyspepsia, causes vomitting and drops, one day times of defecation is up to more than 10 times, and anus redness, with enteritis, dewater comparatively serious, local hospital treatment 4 days, do not take a turn for the better, aggravation on the contrary, arrive again Beijing Hospital's hospitalization, within 8 days, treat to have no resolution afterwards and return.In the situation that being driven into a corner, learn medicine of the present invention, within one day, take three times, two the course for the treatment of times of defecation reduce gradually, three courses for the treatment of, stool was normal, after the 4th course for the treatment of, all are normal for test excrement, appetite increases, body constitution is recovered gradually.
4, Wang, female, 33 years old, people from Dalian, because suffering from indiestion, often diarrhoea, existing more than 2 years, start upon somebody's introduction to take medicine of the present invention, largely alleviated after treat two courses for the treatment of, fully recover after treating three courses for the treatment of, do not recur so far.
5, Pueraria lobota, man, 25 years old, people from Changchun, Jilin, when medical: stomachache, shiver with cold, high heat.Be acute abdominal pain through hospital diagnosis.Take 1 course for the treatment of of Drug therapy of the present invention, symptom disappears completely, cures.
6, week certain, female, 13 years old, people from Xuzhou, nearly two weeks every day watery stool for several times, without suffering from abdominal pain, do not generate heat.Anus has burning sensation after an action of the bowels.Be diagnosed as diarrhoea, take medicine of the present invention, the morning, noon and afternoon respectively once, each 2, observe after treating two courses for the treatment of, stool is normal, described transference cure.
Claims (5)
1. a medicine for the treatment of stomachache, diarrhoea, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
55～80 parts of 59～85 parts of Radix Rubi Multibracteatis of 60～85 parts of thorn corianders of 65～90 parts of Carapax Trionycis of Geranium strictipes R. Kunth
45～66 parts of 47～70 parts of Herba Centellaes of 50～75 parts of Semen Raphanis of 51～78 parts of Cortex betulae platyphyllaes of catechu
40～53 parts of 40～60 portions of Heritiera littoralis Aites of 42～61 parts of Ilex purpurea Hassk.[I.chinensis Sims of 45～65 portions of Fructus Elaeagni Angustifoliaes of Herba Turczaninowiae Fastigiatae
20～40 parts of 32～49 parts of purple oil wood 30～45 Fen Fructus cydoniae oblongae of 35～50 parts of Radix Cucubalis of Chalk;
The preparation method of making described medicine comprises following processing step:
(1) Radix Rubi Multibracteati, catechu, Semen Raphani, Herba Turczaninowiae Fastigiatae, Fructus Elaeagni Angustifoliae, Ilex purpurea Hassk.[I.chinensis Sims, Heritiera littoralis Ait, Radix Cucubali and purple oil wood are cleaned, put into container, add the distilled water of 8～12 times of amounts, soak after 4～5 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 50 DEG C, relative density is 1.10～1.14, for subsequent use;
(2) will sting coriander, Herba Centellae and clean, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(3) Carapax Trionycis is cleaned, dried, slow fire is fried, and fries to 30～50 minutes, takes out, and grinds into powder, crosses 120 order fine powders, for subsequent use;
(4) by Geranium strictipes R. Kunth with Fructus cydoniae oblongae is cleaned, immerse 80% alcohol solution dipping 1-2 hour of 6 times of amounts, reflux, extract, 1 hour, filters, by the thick paste of relative density 1.20～1.25 under 60 DEG C of environment of filtrate simmer down to, for subsequent use;
(5) Cortex betulae platyphyllae and Chalk are mixed, after mix homogeneously, carry out pulverization process, grind into powder, cross 200 order fine powders, for subsequent use;
(6) thick paste made above-mentioned steps (1)～(5), juice and fine powder are mixed, add adjuvant, utilize modern advanced pharmacy science and technology, make tablet, obtain described treatment stomachache, the medicine of diarrhoea.
2. a kind of medicine for the treatment of stomachache, diarrhoea according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
60～77 parts of 61～80 parts of Radix Rubi Multibracteatis of 65～81 parts of thorn corianders of 70～85 parts of Carapax Trionycis of Geranium strictipes R. Kunth
49～63 parts of 50～67 parts of Herba Centellaes of 54～70 parts of Semen Raphanis of 55～75 parts of Cortex betulae platyphyllaes of catechu
42～50 parts of 43～55 portions of Heritiera littoralis Aites of 45～58 parts of Ilex purpurea Hassk.[I.chinensis Sims of 48～60 portions of Fructus Elaeagni Angustifoliaes of Herba Turczaninowiae Fastigiatae
23～37 parts of 35～45 parts of purple oil wood 33～40 Fen Fructus cydoniae oblongae of 38～47 parts of Radix Cucubalis of Chalk.
3. a kind of medicine for the treatment of stomachache, diarrhoea according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
63～73 parts of 65～75 parts of Radix Rubi Multibracteatis of 70～76 parts of thorn corianders of 75～80 parts of Carapax Trionycis of Geranium strictipes R. Kunth
53～60 parts of 55～65 parts of Herba Centellaes of 57～65 parts of Semen Raphanis of 60～70 parts of Cortex betulae platyphyllaes of catechu
44～47 parts of 45～50 portions of Heritiera littoralis Aites of 48～55 parts of Ilex purpurea Hassk.[I.chinensis Sims of 50～56 portions of Fructus Elaeagni Angustifoliaes of Herba Turczaninowiae Fastigiatae
25～32 parts of 38～42 parts of purple oil wood 35～37 Fen Fructus cydoniae oblongae of 40～45 parts of Radix Cucubalis of Chalk.
4. a kind of medicine for the treatment of stomachache, diarrhoea according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
68 parts of 70 parts of Radix Rubi Multibracteatis of 73 parts of thorn corianders of 78 parts of Carapax Trionycis of Geranium strictipes R. Kunth
57 parts of 60 parts of Herba Centellaes of 61 parts of Semen Raphanis of 65 parts of Cortex betulae platyphyllaes of catechu
45 parts of 48 portions of Heritiera littoralis Aites of 51 parts of Ilex purpurea Hassk.[I.chinensis Sims of 53 portions of Fructus Elaeagni Angustifoliaes of Herba Turczaninowiae Fastigiatae
28 parts of 40 parts of wooden 36 Fen Fructus cydoniae oblongae of purple oil of 43 parts of Radix Cucubalis of Chalk.
5. a preparation method for the medicine for the treatment of stomachache, diarrhoea as described in claim 1-4 any one, is characterized in that: comprise following processing step:
(1) Radix Rubi Multibracteati, catechu, Semen Raphani, Herba Turczaninowiae Fastigiatae, Fructus Elaeagni Angustifoliae, Ilex purpurea Hassk.[I.chinensis Sims, Heritiera littoralis Ait, Radix Cucubali and purple oil wood are cleaned, put into container, add the distilled water of 8～12 times of amounts, soak after 4～5 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 50 DEG C, relative density is 1.10～1.14, for subsequent use;
(2) will sting coriander, Herba Centellae and clean, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(3) Carapax Trionycis is cleaned, dried, slow fire is fried, and fries to 30～50 minutes, takes out, and grinds into powder, crosses 120 order fine powders, for subsequent use;
(4) by Geranium strictipes R. Kunth with Fructus cydoniae oblongae is cleaned, immerse 80% alcohol solution dipping 1-2 hour of 6 times of amounts, reflux, extract, 1 hour, filters, by the thick paste of relative density 1.20～1.25 under 60 DEG C of environment of filtrate simmer down to, for subsequent use;
(5) Cortex betulae platyphyllae and Chalk are mixed, after mix homogeneously, carry out pulverization process, grind into powder, cross 200 order fine powders, for subsequent use;
(6) thick paste made above-mentioned steps (1)～(5), juice and fine powder are mixed, add adjuvant, utilize modern advanced pharmacy science and technology, make tablet, obtain described treatment stomachache, the medicine of diarrhoea.
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| CN1368323A (en) * | 2001-02-05 | 2002-09-11 | 杨孟君 | Nano medicine 'Zhixieling' and its preparing process |
| CN101780252A (en) * | 2010-02-28 | 2010-07-21 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine compound for treating intestinal obstruction and preparation method thereof |
| CN101785845A (en) * | 2010-02-28 | 2010-07-28 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine combination and preparation method for intestinal flatulence treatment |
| CN102613421A (en) * | 2012-04-18 | 2012-08-01 | 贵州省畜牧兽医研究所 | Feed additive for preventing newborn pig diarrhea and using method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1368323A (en) * | 2001-02-05 | 2002-09-11 | 杨孟君 | Nano medicine 'Zhixieling' and its preparing process |
| CN101780252A (en) * | 2010-02-28 | 2010-07-21 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine compound for treating intestinal obstruction and preparation method thereof |
| CN101785845A (en) * | 2010-02-28 | 2010-07-28 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine combination and preparation method for intestinal flatulence treatment |
| CN102613421A (en) * | 2012-04-18 | 2012-08-01 | 贵州省畜牧兽医研究所 | Feed additive for preventing newborn pig diarrhea and using method thereof |
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