Background technology
After parturient childbirth, lower abdomen pain person, is called " puerperal abdonimal pain ", claims again " after-pains ".Primary disease is equivalent to the puerperal uterine contraction pain of western medicine and the stomachache that puerperal infection causes.
In general, cause the reason of women's lower abdominal pain, can be divided into the hypogastralgia that the relevant pain causing of menstrual cycle and non-menstrual cycle cause.Primipara because of uterus fiber comparatively tight, uterine contraction is very not strong, easily restore, and it is also shorter to restore required time, pain is not obvious; Multipara is due to multiple pregnancies, and uterus muscle fiber is tractive repeatedly, and it is more difficult to restore, and pain time extends relatively, and pain also compared with primipara more acutely.
Puerperal abdonimal pain comprises stomachache and lower abdominal pain, the most common with lower abdomen pain, mostly due to blood stasis, asthenia of qi and blood, or due to being affected by the cold, the postnatal blood stasis of take stagnates or the air-cooled blood stasis of holding under the arm is the name " after-pains " of leading, and lower abdomen can touch lump, has obvious tenderness, normal doublely see that lochia is not freely or, distension and fullness of the chest and abdomen, Grating is strong for many strings of arteries and veins, has difference partially cold, partial heat.Every easily affection of exogenous wind-cold of asthenia of qi and blood, common stomachache happiness heat is pressed, often touch less than lump, Light-headedness, the tired fear of body is cold, very cardiopalmus, breathe hard, pale tongue, deficient and thready pulse or string Grating; As hold blood stasis under the arm, bitterly, body of the tongue is how purple dim for hardness in the lower abdomen; The stagnation of QI of holding concurrently have diseases such as abdominal distention uncomfortable in chest, large loose stool is thin.Puerperal, lower abdomen pain was main person, claimed puerperal abdonimal pain.Common with new puerpera, refer to the contraction pain causing during uterine contraction puerperal, claim again " puerperal pain ", " uterine contraction pain ".
The traditional Chinese medical science is included into puerperal abdonimal pain " treat pain in abdomen puerperal ", " after-pains " category.The cause of disease be puerperal QI-blood circulation not smooth, the stagnant stagnation of QI and blood may bring about pain of the stasis of blood, can be due to blood trouble in puerperal, vessels of the whole body being deficient, blood-deficiency and QI-insufficiency, carry out unable so that thrombosis and the stasis of blood is stagnant; Also can be due to puerperal asthenia, cold-evil takes advantage of a weak point, and blood is cold coagulation, stops stagnation of QI and blood may bring about pain and causing in blood stasis.Western medicine claims " uterine contraction pain ", " puerperal pain ", belongs to physiological phenomenon, does not generally need treatment.The a burst of aggravation if suffer from abdominal pain, endurable, or continuous and dull pain in the abdomen, pain endlessly, affects perinatal health, is morbid state, should treat.
At present both at home and abroad to the puerperal abdonimal pain treatment Therapeutic Method that adopt doctor trained in Western medicine more, for treatment puerperal abdonimal pain, still there is no desirable specific medicament, although some medicine has certain effect to gynaecopathias such as puerperal abdonimal pains, but its therapeutic effect is unsatisfactory, and at the bottom of security performance, side effect is large, is not easy to clinical wide popularization and application.
Summary of the invention
The invention provides a kind of medicine and preparation method that is used for the treatment of puerperal abdonimal pain; Medicine of the present invention have enrich blood invigorate blood circulation, the effect of antalgic, circulation of qi promoting dissipating blood stasis, expelling wind and removing dampness, the abdominal pain symptom causing puerperal is had to significant curative effect, safe and reliable, without any side effects, can suppress puerperal abdonimal pain, promote WomanHealth and have positive effect, clinical trial shows, to the total effective rate of puerperal abdonimal pain patient treatment up to 96.9%, clinic wide popularization and application.
For achieving the above object, technical scheme of the present invention is implemented as follows:
A medicine that is used for the treatment of puerperal abdonimal pain, raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
A preparation method that is used for the treatment of the medicine of puerperal abdonimal pain, comprises following processing step:
(1) Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), gristle wind, Fructus Crataegi, Pollen Typhae, Radix Ribis davidii and Radix Lagerstroemia indica L. are cleaned, put into container, add the distilled water of 8~10 times of amounts, soak after 5~6 hours, boil 3~4 hours, extract; Again add 6~8 times of amount distilled water, boil 2~3 hours, extract; Finally, add 4~6 times of amount distilled water, heated and boiled 1~2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, the thick paste that at 65 ℃ of simmer down tos, relative density is 1.10~1.16, standby;
(2) Rhizoma Lycopi Lucidi, Celastrus gemmatus Loes., Herba Rubi parvifolii and Cortex Euonymi phellomanis are cleaned, immersed 80% the alcohol solution dipping 3~4 hours of 6 times of amounts, heating and refluxing extraction 2~3 hours, reclaim ethanol, filter, by the thick paste of relative density 1.20~1.25 under 60 ℃ of environment of filtrate simmer down to, standby;
(3) Olibanum is clean, put in pot and fry and to surface, slightly see melting point with slow fire, be slightly yellow, after taking-up cools, grind into powder, cross 180 order fine powders;
(4) Radix seu Caulis Kadsurae Heteroclitae, Herba Lycopi and Herba leonuri pseudoma cranthi are mixed, after mix homogeneously, carry out pulverization process, grind into powder, cross 160 order fine powders, standby;
(5) Herba artemisiae lactiflorae and Rhizoma Dioscoreae Cirrhosae are cleaned, dry at shady and cool place, and chopping, puts into container, strand juice, and filter impurity, stays juice standby;
(6) above-mentioned steps (1)~(5) prepared thick paste, fine powder and juice are mixed, make pill, obtain the medicine that is used for the treatment of puerperal abdonimal pain of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae): mildly bitter flavor, warm in nature.Expelling wind and removing dampness, promoting blood circulation and stopping pain.Dispelling the wind and dampness pathogens arthralgia pain, stomachache, injury and bone fracture, traumatic hemorrhage.The practical Chinese herbal medicine in < < Guangxi newly selects > >: " promoting the circulation of QI to relieve pain, promoting blood circulation and detumescence, strengthening bone and muscle.Control acute rheumatic arthritis, stomachache, fracture, bruise, lumbago and skelalgia, paralysis."
Rhizoma Lycopi Lucidi: sweet in the mouth, pungent, property is flat.Invigorate blood circulation, QI invigorating, water disappears.Cure mainly haematemesis, epistaxis, puerperal abdonimal pain, leukorrhagia.< < Japan hanako materia medica > > carries: " only serious epistaxis, spits blood, puerperal cardiac and abdominal pain.”
Gristle wind: sweet in the mouth, micro-puckery, property is flat; Return liver, kidney channel.Expelling wind and removing dampness, eliminating stasis to stop pain.Cure mainly pain of dampness syndrome, lumbago, puerperal abdonimal pain, traumatic injury.
Olibanum: bitter in the mouth, property is pungent, warm; Enter the heart, liver, spleen channel.Invigorate blood circulation, circulation of qi promoting, pain relieving.Cure mainly the epigastric pain of the stasis blocking stagnation of QI, rheumatic arthralgia, traumatic injury, dysmenorrhea, puerperal abdonimal pain.< < detailed outline > > carries: " all poison of eliminating carbuncle cellulitis, the heart is protected in Tuoli, and the analgesic therapy of invigorating blood circulation, stretches muscle, controls married woman's difficult labour, injured." modern medicine study confirmation, Olibanum has analgesia bacteriostasis.
Celastrus gemmatus Loes.: bitter in the mouth, pungent, property is flat; Return liver, stomach warp.Expelling wind and removing dampness, promoting blood circulation and stopping pain, removing toxic substances and promoting subsidence of swelling.Cure mainly rheumatic arthralgia, traumatic injury, menoxenia, amenorrhea, puerperal abdonimal pain, stomachache, colic, sore, carbuncle and painful swelling, fracture, rubella, eczema, herpes zoster, venom.
Radix seu Caulis Kadsurae Heteroclitae: acrid in the mouth, hardship, warm in nature; Return spleen, stomach, Liver Channel.Expelling wind and removing dampness, promoting the circulation of QI to relieve pain, relaxing muscles and tendons and activating QI and blood in the collateral.Cure mainly rheumatic arthralgia, stomachache, stomachache, dysmenorrhea, puerperal abdonimal pain, traumatic injury, chronic lambago and skelalgia.< < Guangxi Chinese herbal medicine > > carries: " promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain, wind-damp dispelling.Control traumatic injury, rheumatic ostalgia, dysmenorrhea, puerperal abdonimal pain, acute/chronic gastroenteritis.”
Herba Lycopi: bitter in the mouth, pungent, slightly warm in nature; Return liver, spleen channel.Blood circulation promoting and blood stasis dispelling, line water detumescence.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis stomachache, edema.< < property of medicine opinion > > carries: " main puerperal abdonimal pain, frequently produces the vim and vigour cold one-tenth labor that declines, and thin win, controls again the whole body appearance swollen greatly, housewife's human blood drop lumbago.”
Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature; Return spleen, stomach, Liver Channel.Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.< < detailed outline > > carries: " dissipating fluid-retention food, the meat Ji , mass in the abdomen that disappears, phlegm retention feeling of fullness acid regurgitation, stagnant blood pain with distension.”
Pollen Typhae: sweet in the mouth, property is flat; Return liver, pericardium channel.Hemostasis, blood stasis dispelling, treating stranguria.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, blood strangury and dry pain.< < Japan hanako materia medica > > carries: " controlling (top), to flutter blood vexed, evacuation of pus, furuncle; married woman's leukorrhagia, month wait irregular, vim and vigour cardiac and abdominal pain; pregnant pregnant people's hematochezia fetal abortion, blood Yun mass resulting from the blood stasis, youngster rests the head on shoot; urinary obstruction, hemorrhoidal hamorrhage rushes down blood, urticaria toxic swelling; serious epistaxis is spitted blood; stimulating milk secretion, stopping leak essence, dysentery.Removing blood stasis detumescence is raw to be made, and tonifying blood and arresting bleeding is fried and used.”
Radix Ribis davidii: puckery, hardship, slightly warm in nature; Return liver,spleen,kidney warp.Blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons is regulated the flow of vital energy.Cure mainly rheumatic arthritis, menoxenia, amenorrhea lumbago, puerperal abdonimal pain, dysentery.The book on Chinese herbal medicine outline > > of < < Xinhua carries: " the function that has relaxing muscles and tendons to promote blood circulation, stasis-dispelling and pain-killing, bone and muscle strengthening.For rheumatic arthritis, menoxenia, lumbago.”
Herba Rubi parvifolii: bitter in the mouth, puckery, cool in nature, nontoxic; Return liver, lung, kidney channel.Heat-clearing and toxic substances removing, dissipating blood stasis hemostasis, parasite killing is treated skin ulcer.Cure mainly cold, fever, cough expectorant blood, dysentery, traumatic injury, puerperal abdonimal pain, scabies, furuncle and phyma, traumatic hemorrhage.The medicine will > > of < < Nanning City carries: " dissipating blood stasis, pain relieving are reduced phlegm.Control traumatic injury, cough, puerperal stasis of blood pain, bloody dysentery, heat eye.”
Herba leonuri pseudoma cranthi: acrid in the mouth, micro-hardship, cold nature.Promoting blood flow to regulate menstruation, removing toxic substances and promoting subsidence of swelling.Cure mainly menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis stomachache, metrorrhagia, traumatic pain, carbuncle sore.< < Bencao Shiyi > > carries: " main removing blood stasis.Puerperal abdonimal pain, liquor takes it; Also smash deposited furuncle to pieces.”
Herba artemisiae lactiflorae: sweet in the mouth, micro-hardship, property is flat.Vital energy regualting and blood circulation-promoting, regulating menstruation dampness removing, removing toxic substances and promoting subsidence of swelling.For menoxenia, amenorrhea, chronic hepatitis, liver cirrhosis, oedema due to nephritis, leucorrhea, urticaria, abdominal distention, hernia; Traumatic injury is controlled in external, traumatic hemorrhage, burn and scald, skin infection, eczema.The < < record > > that gathers medicinal herbs in the south of the Five Ridges carries: " promoting blood circulation to restore menstrual flow, treats cholera watery diarrhea, and only incised wound is hemorrhage.Control burn, motive pain, watery distension, size is had blood in stool.”
Radix Lagerstroemia indica L.: mildly bitter flavor, cold nature.Clearing away heat-damp and promoting diuresis, promoting blood circulation and hemostasis, pain relieving.Cure mainly dysentery, edema, burn and scald, eczema, eczema, carbuncle sore tumefacting virus, traumatic injury, metrorrhagia, migraine, toothache, dysmenorrhea, puerperal abdonimal pain.
Rhizoma Dioscoreae Cirrhosae: bitter in the mouth, cool in nature, mild toxicity.Promoting blood circulation and hemostasis, regulating QI to relieve pain, heat-clearing and toxic substances removing.Cure mainly hemoptysis, spitting of blood, hematemesis, epistaxis, hematuria, has blood in stool, metrorrhagia, menoxenia, dysmenorrhea, amenorrhea, puerperal abdonimal pain, abdominal distention, erputive abdominal disease, toxic-heat and blood stasis, watery diarrhea, arthralgia, treating swelling and pain by traumatic injury, furuncle, herpes zoster, traumatic hemorrhage.< < Guizhou side's medicine among the people collection > > carries: " dysentery relieving disease.Control puerperal abdonimal pain, tympanites; Control again asthma.”
Cortex Euonymi phellomanis: cold in nature, bitter in the mouth; Enter liver, lung two warps.The removing blood stasis tire that falls, regulating menstruation Radix Dipsaci.Control puerperal abdonimal pain, metrorrhagia hematochezia, rheumatalgia.
The present invention compared with prior art, has following beneficial effect:
Medicine of the present invention have enrich blood invigorate blood circulation, the effect of antalgic, circulation of qi promoting dissipating blood stasis, expelling wind and removing dampness, the abdominal pain symptom causing puerperal is had to significant curative effect, safe and reliable, without any side effects, can suppress puerperal abdonimal pain, promote WomanHealth and have positive effect, clinical trial shows, to the total effective rate of puerperal abdonimal pain patient treatment up to 96.9%, clinic wide popularization and application.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of effective ingredient of the present invention forms and weight is:
A preparation method that is used for the treatment of the medicine of puerperal abdonimal pain, comprises following processing step:
(1) Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), gristle wind, Fructus Crataegi, Pollen Typhae, Radix Ribis davidii and Radix Lagerstroemia indica L. are cleaned, put into container, add the distilled water of 8~10 times of amounts, soak after 5~6 hours, boil 3~4 hours, extract; Again add 6~8 times of amount distilled water, boil 2~3 hours, extract; Finally, add 4~6 times of amount distilled water, heated and boiled 1~2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, the thick paste that at 65 ℃ of simmer down tos, relative density is 1.10~1.16, standby;
(2) Rhizoma Lycopi Lucidi, Celastrus gemmatus Loes., Herba Rubi parvifolii and Cortex Euonymi phellomanis are cleaned, immersed 80% the alcohol solution dipping 3~4 hours of 6 times of amounts, heating and refluxing extraction 2~3 hours, reclaim ethanol, filter, by the thick paste of relative density 1.20~1.25 under 60 ℃ of environment of filtrate simmer down to, standby;
(3) Olibanum is clean, put in pot and fry and to surface, slightly see melting point with slow fire, be slightly yellow, after taking-up cools, grind into powder, cross 180 order fine powders;
(4) Radix seu Caulis Kadsurae Heteroclitae, Herba Lycopi and Herba leonuri pseudoma cranthi are mixed, after mix homogeneously, carry out pulverization process, grind into powder, cross 160 order fine powders, standby;
(5) Herba artemisiae lactiflorae and Rhizoma Dioscoreae Cirrhosae are cleaned, dry at shady and cool place, and chopping, puts into container, strand juice, and filter impurity, stays juice standby;
(6) above-mentioned steps (1)~(5) prepared thick paste, fine powder and juice are mixed, make pill, obtain the medicine that is used for the treatment of puerperal abdonimal pain of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 1 (every 0.8g); Within 5 days, be 1 course for the treatment of, can fully recover 2~4 courses for the treatment of, and the person of being in a bad way follows the doctor's advice and drinks the amount of adding.
Embodiment 2
The raw material of effective ingredient of the present invention forms and weight is:
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
The raw material of effective ingredient of the present invention forms and weight is:
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 4
The raw material of effective ingredient of the present invention forms and weight is:
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 5
The raw material of effective ingredient of the present invention forms and weight is:
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Clinical data:
1, case selection:
As the medicine that is used for the treatment of puerperal abdonimal pain, select puerperal abdonimal pain patient 130 routine clinical observations, patient is divided into two groups for the treatment of group and matched groups, treatment group women's 65 examples, 18~43 years old age, 30.5 years old mean age, the course of disease 1~2 year at random; Matched group women 65 examples, 19~42 years old age, 29.7 years old mean age, the course of disease 1~2 year; The course of disease, the degrees of symptoms for the treatment of group and two groups of cases of matched group are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group is taken medicine of the present invention, oral, every day 2 times, each 1 time sooner or later, each 1 (every 0.8g); Within 5 days, be 1 course for the treatment of, take continuously 2~4 courses for the treatment of, the person of being in a bad way follows the doctor's advice and drinks the amount of adding; Matched group is taken Nuo Fosha star capsule, oral, a 400mg, 2 times on the one.
3, efficacy determination:
(1) cure: pain symptom disappears, and physical recovery is normal.
(2) effective: pain symptom obviously alleviates, it is normal that health recovers substantially.
(3) effective: pain symptom is link to some extent, it is normal that health obviously recovers.
(4) invalid: by treating rear pain symptom without alleviating or increasing the weight of.
4, result:
? |
Number of cases |
Cure |
Effective |
Effectively |
Invalid |
Cure rate |
Total effective rate |
Treatment group |
65 |
35 |
16 |
12 |
2 |
53.8% |
96.9% |
Matched group |
65 |
11 |
15 |
16 |
23 |
16.9% |
64.6% |
Above result demonstration, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is given an example:
1, Shen, female, 20 years old, people from Shijiazhuang, Hebei.Patient's lower abdomen pain in 5 days puerperal, tenderness, obtains burning pain slow, and lochia amount is few, and not smooth not smooth color purple secretly has piece, alleviation of pain under piece, companion's distending pain in the chest and hypochondrium.After being in hospital, oral Drug therapy of the present invention, every day 2 times, each 1 time sooner or later, each 1 (every 0.8g); Take after 1 course for the treatment of, colic symptoms is clearly better, and continues to take after 1 course for the treatment of, and colic symptoms disappears, and disease recovery from illness, has no recurrence.
2, health, female, 25 years old, people from Jinzhou, Liaoning.Patient is during 6 days puerperal, and hot summer days are greedy cool, do not build abdominal part night, so that are affected by the cold, next morning lower abdomen pain, pain gesture is violent, lochia is only poly-, soreness of the loins and weakness of the limbs, dizziness order flower.After being in hospital, give medicine of the present invention, take after 1 course for the treatment of, conscious lower abdomen pain symptom obviously alleviates, and takes after 2 courses for the treatment of, and all diseases disappear, and physical recovery is healthy.
3, turn round and look at certain, female, 28 years old, people from Liaoyuan, Jilin.After patient's cesarean, pelvic adhesion occurs, suffer from abdominal pain 1 year, the HSG of outer court reminds on bilateral fallopian tube and lifts, pelvic adhesion, and it is obvious abnormal that B ultrasonic prompting uterus adnexa has no.Preoperative inspection routine blood test: leukocyte: 4.5 * 10 (9)/L, erythrocyte: 4.45 * 10 (12)/L, hemoglobin: 109g/L, platelet: 300 * 10 (9)/L, abo blood group: O type, RH (D) blood group: the positive; Electrocardiogram, rabat, four of blood coagulations, Liver and kidney merit are all without significantly peculiar; C-hepatitis antibody, syphilis antibody, aids antibody are all negative; Leucorrhea convention: totally spend III degree, without infusorian mycete.AD: chronic pelvic pain, pelvic adhesion, after cesarean section.Give medicine of the present invention, take after 1 course for the treatment of, above-mentioned colic symptoms obviously alleviates, and takes after 3 courses for the treatment of, and all diseases are eliminated, and follows up a case by regular visits to without recurrence after 1 year.
4, money, female, 32 years old, people from Mudanjiang, Heilungkiang.Patient's cesarean has lower abdomen indistinctly to do the situation of pain always after 3 months, and particularly exert all one's strength when large and increase the weight of, and with symptoms such as leucorrhea jaundice.After diagnosis, start to take medicine of the present invention, to check after taking 1 course for the treatment of of the present invention, puerperal abdonimal pain turns for the better by and large, and takes again 1 course for the treatment of of medicine of the present invention, and puerperal abdonimal pain disappears, and physical recovery is healthy, does not follow up a case by regular visits to recurrence.
5, side certain, female, 27 years old, people from Changchun, Jilin.Patient has produced two wheat harvesting periods, and side cutting knife mouth is itched a little, and lower abdomen is a little very slight dull pain always, very uncomfortable sensation, and once in a while with very light very light pink colour mucus, after admission examination, there is light inflammation, cause is in age of sucking, doctor advised is taken medicine of the present invention, checks after taking 3 courses for the treatment of of the present invention, and puerperal abdonimal pain disappears, physical recovery is healthy, follows up a case by regular visits to not recurrence.
6, season, female, 26 years old, people from Weihai in Shandong province.Patient does cesarean 1 year, and there are two not only enclosed mass of hard but also circle on wound both sides, the severity of front pain in the period along with through after just so not bitterly, go to a lot of hospitals to seek medical advice and all can not check reason, catch now cervical erosion, after diagnosis, start to take medicine of the present invention, after taking 1 course for the treatment of of the present invention, check, puerperal abdonimal pain turns for the better by and large, and takes again 2 courses for the treatment of of medicine of the present invention, and puerperal abdonimal pain disappears, physical recovery is healthy, follows up a case by regular visits to not recurrence.