CN107050258A - A kind of pharmaceutical composition for treating postpartum abdominal pain - Google Patents
A kind of pharmaceutical composition for treating postpartum abdominal pain Download PDFInfo
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- CN107050258A CN107050258A CN201611009757.2A CN201611009757A CN107050258A CN 107050258 A CN107050258 A CN 107050258A CN 201611009757 A CN201611009757 A CN 201611009757A CN 107050258 A CN107050258 A CN 107050258A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/483—Gleditsia (locust)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
A kind of to treat pharmaceutical composition of postpartum abdominal pain and preparation method thereof, the pharmaceutical composition is made up of the medicine of following parts by weight：Garlic, Chinese honey locust (fruit), Rhizoma Belamcandae, FRUCTUS TERMINALIAE IMMATURUS, carbonized hair, red ginseng, bark of tree of heaven, stiff silkworm, Exocarpium Citri Grandis, peach branch, the seed of cowherb, radix glycyrrhizae, it is made up of techniques such as alcohol extractings, treat postpartum abdominal pain 315, the efficient average out to 94.3% of each embodiment, effect is obvious, and adverse reaction and toxic side effect are not found, illustrate that pharmaceutical composition of the present invention is evident in efficacy in treatment postpartum abdominal pain, with good promotional value.
Description
Technical field
The present invention relates to field of medicine invention, and in particular to a kind of pharmaceutical composition for treating postpartum abdominal pain and its preparation side
Method.
Background technology
Within puerperium the underbelly pain relevant with childbirth or puerperium, referred to as postpartum abdominal pain occur for puerpera.It is mainly shown as
To there is lower abdomen paroxysmal intense pain in puerperium after production, or underbelly has a dull ache, and does not understand within many days, not with fever and chills, often
Few with lochia amount, color purple is dim block, discharges not smooth；Or lochia amount is few, color is light red.This sick main pathogenesis be QI-blood circulation not
Freely, not Rong Ze pains or not general rule pain.Uterine retraction and puerpera's condition are closely related after the generation and production of postpartum abdominal pain.It is pregnant
It is pregnent the phase, uterus installing but not discharging saves and preserve essence and blood, moistens nourishing the fetus youngster, as carcass gradually increases, uterus gradually stores extremely.After childbirth, tire
Under youngster, afterbirth time the are all, uterus is rushed down by hiding, and by swollen full in hollow state, in addition the turbid liquid of the remaining blood of uterine retraction discharge, son
Palace is during a surname one is rushed down herein, and qi and blood changes drastically, if puerpera's body is strong, is suitable for more.If puerpera's ferritic deficient qi and blood, or production
When excessive blood loss, or postpartum take good care of oneself improper, and cause the deficiency of blood, punching is appointed, vessels of the uterus loses, not Rong Ze pain foster in moistening；Or the turbid liquid of blood more than uterus,
Cause is cold to cause the stasis of blood, or qi depression to blood stasis, or afterbirth, Placenta remnants, rushes, appoints, vessels of the uterus blocks, not general rule pain.The common cause of disease is qi and blood
Two is empty, the stagnant uterus of the stasis of blood.
Postpartum abdominal pain not only has a strong impact on the mood and health of puerpera, and prevents puerpera from normal lactation baby, if not
Treatment can also cause massive haemorrhage in time, and threat to life, doctor trained in Western medicine mainly based on analgesic, is cured the symptoms, not the disease, and Chinese traditional treatment is with qi-restoratives
Stagnation resolvation, is adjusted based on smooth qi and blood.Nourishing for deficiency and adjust it, real person is logical and adjusts it, promotes gas congested smooth, vessels of the uterus circulation then stomachache from removing.
When facing card, according to the characteristics of postpartum multiple deficiency and stasis, medication does not grow greasy excessively, also do not attack excessively by, make vessels of the uterus hemapodium gas fill moisten it is foster
Uterus, qi and blood passes unimpeded, and lochia discharge, uterine retraction is normal, then stomachache is self solved.At present, the Chinese medicine for the treatment of postpartum abdominal pain has a lot
Kind, but good actually rare of effect, therefore research and develop a kind of medicine of the good Small side effects of therapeutic effect be it is clinical in the urgent need to.
In order to solve the above problems, inventor have developed a kind of new drug for treating postpartum abdominal pain.
The content of the invention
It is an object of the invention to provide a kind of pharmaceutical composition for treating postpartum abdominal pain.
It is a further object of the present invention to provide a kind of pharmaceutical composition preparation method for treating postpartum abdominal pain.
The pharmaceutical composition for the treatment postpartum abdominal pain that the present invention is provided is made up of the medicine of following parts by weight：Garlic 50-80
Part, 10-30 parts of Chinese honey locust (fruit), 10-30 parts of Rhizoma Belamcandae, 5-13 parts of FRUCTUS TERMINALIAE IMMATURUS, 5-12 parts of carbonized hair, 10-30 parts of red ginseng, bark of tree of heaven 8-16
Part, 5-14 parts of stiff silkworm, 10-30 parts of Exocarpium Citri Grandis, 15-40 parts of peach branch, 6-15 parts of the seed of cowherb, 10-30 parts of radix glycyrrhizae.
It is preferred that, pharmaceutical composition of the present invention is made up of the medicine of following parts by weight：55-75 parts of garlic, big soap
Angle 12-28 parts, 12-28 parts of Rhizoma Belamcandae, 6-12 parts of FRUCTUS TERMINALIAE IMMATURUS, 6-11 parts of carbonized hair, 12-28 parts of red ginseng, 9-15 parts of bark of tree of heaven, stiff silkworm
7-12 parts, 12-28 parts of Exocarpium Citri Grandis, peach branch 18-35 parts, 7-14 parts of the seed of cowherb, 12-28 parts of radix glycyrrhizae.
It is further preferred that pharmaceutical composition of the present invention is made up of the medicine of following parts by weight：Garlic 58-72
Part, 15-25 parts of Chinese honey locust (fruit), 15-25 parts of Rhizoma Belamcandae, 7-11 parts of FRUCTUS TERMINALIAE IMMATURUS, 7-10 parts of carbonized hair, 15-25 parts of red ginseng, bark of tree of heaven 10-
14 parts, 8-11 parts of stiff silkworm, 15-26 parts of Exocarpium Citri Grandis, peach branch 22-31 parts, 8-13 parts of the seed of cowherb, 15-25 parts of radix glycyrrhizae.
Still more preferably, pharmaceutical composition of the present invention is made up of the medicine of following parts by weight：Garlic 62-70
Part, 17-23 parts of Chinese honey locust (fruit), 17-23 parts of Rhizoma Belamcandae, 8-10 parts of FRUCTUS TERMINALIAE IMMATURUS, 8-9 parts of carbonized hair, 17-23 parts of red ginseng, bark of tree of heaven 11-13
Part, 9-10 parts of stiff silkworm, 18-24 parts of Exocarpium Citri Grandis, 24-29 parts of peach branch, 9-12 parts of the seed of cowherb, 18-23 parts of radix glycyrrhizae.
Still more preferably, pharmaceutical composition of the present invention is made up of the medicine of following parts by weight：65 parts of garlic,
20 parts of Chinese honey locust (fruit), 20 parts of Rhizoma Belamcandae, 9 parts of FRUCTUS TERMINALIAE IMMATURUS, 8 parts of carbonized hair, 20 parts of red ginseng, 12 parts of bark of tree of heaven, 9 parts of stiff silkworm, Exocarpium Citri Grandis 21
Part, 27 parts of peach branch, 11 parts of the seed of cowherb, 20 parts of radix glycyrrhizae.
Pharmaceutical composition of the present invention also contains pharmaceutically acceptable carrier or diluent.
Pharmaceutical composition of the present invention be solid pharmaceutical preparation or liquid preparation, the solid pharmaceutical preparation be tablet, capsule,
Granula or pill；The liquid preparation is oral liquid.
The preparation method of pharmaceutical composition of the present invention comprises the following steps：By garlic, Chinese honey locust (fruit), Rhizoma Belamcandae, west
Chinese olive, carbonized hair, red ginseng, bark of tree of heaven, stiff silkworm, Exocarpium Citri Grandis, peach branch, the seed of cowherb, radix glycyrrhizae pulverize and sieve, and pharmaceutically acceptable
Carrier or diluent are well mixed, are prepared into preparation.
The preparation method of pharmaceutical composition of the present invention comprises the following steps：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by red ginseng, that Crinis carbonisatus powder is broken into fine powder is standby；
3) add 2-5 times to measure vinegar-fried 12-16 minutes garlic, Chinese honey locust (fruit), Rhizoma Belamcandae, FRUCTUS TERMINALIAE IMMATURUS, be ground into fine powder, it is standby；
4) 3-7 times of 75% ethanol measured is added to soak 12-16 bark of tree of heaven, stiff silkworm, Exocarpium Citri Grandis, peach branch, the seed of cowherb, radix glycyrrhizae
Hour, filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
5) above-mentioned fine powder is well mixed, adds auxiliary material, pharmaceutically acceptable formulation is made.
It is preferred that, the preparation method of pharmaceutical composition of the present invention comprises the following steps：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by red ginseng, that Crinis carbonisatus powder is broken into fine powder is standby；
3) add 3 times to measure vinegar-fried 14 minutes garlic, Chinese honey locust (fruit), Rhizoma Belamcandae, FRUCTUS TERMINALIAE IMMATURUS, be ground into fine powder, it is standby；
4) 75% ethanol that bark of tree of heaven, stiff silkworm, Exocarpium Citri Grandis, peach branch, the seed of cowherb, radix glycyrrhizae are added into 5 times of amounts soaks 14 hours,
Filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
5) above-mentioned fine powder is well mixed, adds auxiliary material, pharmaceutically acceptable formulation is made.
The parts by weight can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
The implication of amount refers to the weight ratio of medicinal material again.
The pharmaceutically acceptable carrier or diluent refer to the conventional pharmaceutical carrier of pharmaceutical field, selected from filler,
One or more in adhesive, disintegrant, lubricant, surfactant or flavouring.
Wherein described filler is selected from starch, sucrose, lactose, mannitol, sorbierite, xylitol, microcrystalline cellulose or Portugal
Grape sugar etc.；
Described adhesive is selected from cellulose derivative, alginates, gelatin or polyvinylpyrrolidone etc.；
The disintegrant is selected from microcrystalline cellulose, sodium carboxymethyl starch, polyvinylpyrrolidone, low substituted hydroxy-propyl fiber
Element or Ac-Di-Sol；
The lubricant is selected from stearic acid, polyethylene glycol, calcium carbonate, sodium acid carbonate, silica, talcum powder or stearic acid
Magnesium；
The surfactant is selected from neopelex, stearic acid, Pluronic F68, fat
Sorb is smooth or polysorbate (tween) etc. for fat acid；
The flavouring is selected from Aspartame, Sucralose or saccharin sodium.
The pharmaceutical composition that the present invention is provided has advantages below：
Primary treatment clinical manifestation of the present invention is postpartum underbelly severe pain or a few days that has a dull ache is more than, and lochia amount is few, and happiness is pressed
Happiness is rubbed, evident in efficacy in terms of dry and hard excrement；Treat postpartum abdominal pain 315, the efficient average out to 94.3% of each embodiment, effect
Substantially, adverse reaction and toxic side effect and are not found, illustrate that pharmaceutical composition of the present invention is evident in efficacy in treatment postpartum abdominal pain,
With good promotional value.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Prescription：Garlic 50g, Chinese honey locust (fruit) 10g, Rhizoma Belamcandae 10g, FRUCTUS TERMINALIAE IMMATURUS 5g, carbonized hair 5g, red ginseng 10g, bark of tree of heaven 8g, deadlock
Silkworm 5g, Exocarpium Citri Grandis 10g, peach branch 15g, seed of cowherb 6g, radix glycyrrhizae 10g.
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by red ginseng, that Crinis carbonisatus powder is broken into fine powder is standby；
3) add 2 times to measure vinegar-fried 12 minutes garlic, Chinese honey locust (fruit), Rhizoma Belamcandae, FRUCTUS TERMINALIAE IMMATURUS, be ground into fine powder, it is standby；
4) 75% ethanol that bark of tree of heaven, stiff silkworm, Exocarpium Citri Grandis, peach branch, the seed of cowherb, radix glycyrrhizae are added into 3 times of amounts soaks 12 hours,
Filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
5) starch for accounting for well mixed fine powder weight 2/5 is added, loads capsule, capsule is made.
Embodiment 2
Prescription：Garlic 80g, Chinese honey locust (fruit) 30g, Rhizoma Belamcandae 30g, FRUCTUS TERMINALIAE IMMATURUS 13g, carbonized hair 12g, red ginseng 30g, bark of tree of heaven 16g,
Stiff silkworm 14g, Exocarpium Citri Grandis 30g, peach branch 40g, seed of cowherb 15g, radix glycyrrhizae 30g.
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by red ginseng, that Crinis carbonisatus powder is broken into fine powder is standby；
3) add 5 times to measure vinegar-fried 16 minutes garlic, Chinese honey locust (fruit), Rhizoma Belamcandae, FRUCTUS TERMINALIAE IMMATURUS, be ground into fine powder, it is standby；
4) 75% ethanol that bark of tree of heaven, stiff silkworm, Exocarpium Citri Grandis, peach branch, the seed of cowherb, radix glycyrrhizae are added into 7 times of amounts soaks 16 hours,
Filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
5) starch for accounting for well mixed fine powder weight 2/5 is added, loads capsule, capsule is made.
Embodiment 3
Prescription：Garlic 55g, Chinese honey locust (fruit) 12g, Rhizoma Belamcandae 12g, FRUCTUS TERMINALIAE IMMATURUS 6g, carbonized hair 6g, red ginseng 12g, bark of tree of heaven 9g, deadlock
Silkworm 7g, Exocarpium Citri Grandis 12g, peach branch 18g, seed of cowherb 7g, radix glycyrrhizae 12g.
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by red ginseng, that Crinis carbonisatus powder is broken into fine powder is standby；
3) add 3 times to measure vinegar-fried 13 minutes garlic, Chinese honey locust (fruit), Rhizoma Belamcandae, FRUCTUS TERMINALIAE IMMATURUS, be ground into fine powder, it is standby；
4) 75% ethanol that bark of tree of heaven, stiff silkworm, Exocarpium Citri Grandis, peach branch, the seed of cowherb, radix glycyrrhizae are added into 4 times of amounts soaks 13 hours,
Filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
5) starch for accounting for well mixed fine powder weight 1/5 is added, is dried, tabletting produces the tablet of the application.
Embodiment 4
Prescription：Garlic 75g, Chinese honey locust (fruit) 28g, Rhizoma Belamcandae 28g, FRUCTUS TERMINALIAE IMMATURUS 12g, carbonized hair 11g, red ginseng 28g, bark of tree of heaven 15g,
Stiff silkworm 12g, Exocarpium Citri Grandis 28g, peach branch 35g, seed of cowherb 14g, radix glycyrrhizae 28g.
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by red ginseng, that Crinis carbonisatus powder is broken into fine powder is standby；
3) add 4 times to measure vinegar-fried 14 minutes garlic, Chinese honey locust (fruit), Rhizoma Belamcandae, FRUCTUS TERMINALIAE IMMATURUS, be ground into fine powder, it is standby；
4) 75% ethanol that bark of tree of heaven, stiff silkworm, Exocarpium Citri Grandis, peach branch, the seed of cowherb, radix glycyrrhizae are added into 6 times of amounts soaks 15 hours,
Filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
5) starch for accounting for well mixed fine powder weight 1/5 is added, is dried, tabletting produces the tablet of the application.
Embodiment 5
Prescription：Garlic 58g, Chinese honey locust (fruit) 15g, Rhizoma Belamcandae 15g, FRUCTUS TERMINALIAE IMMATURUS 7g, carbonized hair 7g, red ginseng 15g, bark of tree of heaven 10g, deadlock
Silkworm 8g, Exocarpium Citri Grandis 15g, peach branch 22g, seed of cowherb 8g, radix glycyrrhizae 15g.
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by red ginseng, that Crinis carbonisatus powder is broken into fine powder is standby；
3) add 3 times to measure vinegar-fried 14 minutes garlic, Chinese honey locust (fruit), Rhizoma Belamcandae, FRUCTUS TERMINALIAE IMMATURUS, be ground into fine powder, it is standby；
4) 75% ethanol that bark of tree of heaven, stiff silkworm, Exocarpium Citri Grandis, peach branch, the seed of cowherb, radix glycyrrhizae are added into 5 times of amounts soaks 14 hours,
Filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
5) starch for accounting for well mixed fine powder weight 1/5 is added, is mixed, is pelletized, is dried, whole grain obtains of the application
Granula.
Embodiment 6
Prescription：Garlic 72g, Chinese honey locust (fruit) 25g, Rhizoma Belamcandae 25g, FRUCTUS TERMINALIAE IMMATURUS 11g, carbonized hair 10g, red ginseng 25g, bark of tree of heaven 14g,
Stiff silkworm 11g, Exocarpium Citri Grandis 26g, peach branch 31g, seed of cowherb 13g, radix glycyrrhizae 25g.
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by red ginseng, that Crinis carbonisatus powder is broken into fine powder is standby；
3) add 3 times to measure vinegar-fried 14 minutes garlic, Chinese honey locust (fruit), Rhizoma Belamcandae, FRUCTUS TERMINALIAE IMMATURUS, be ground into fine powder, it is standby；
4) 75% ethanol that bark of tree of heaven, stiff silkworm, Exocarpium Citri Grandis, peach branch, the seed of cowherb, radix glycyrrhizae are added into 5 times of amounts soaks 14 hours,
Filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
5) dextrin for accounting for well mixed fine powder weight 1/11 is added, is mixed, pill, dries, obtains the micropill of the application.
Embodiment 7
Prescription：Garlic 62g, Chinese honey locust (fruit) 17g, Rhizoma Belamcandae 17g, FRUCTUS TERMINALIAE IMMATURUS 8g, carbonized hair 8g, red ginseng 17g, bark of tree of heaven 11g, deadlock
Silkworm 9g, Exocarpium Citri Grandis 18g, peach branch 24g, seed of cowherb 9g, radix glycyrrhizae 18g
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by red ginseng, that Crinis carbonisatus powder is broken into fine powder is standby；
3) add 3 times to measure vinegar-fried 14 minutes garlic, Chinese honey locust (fruit), Rhizoma Belamcandae, FRUCTUS TERMINALIAE IMMATURUS, be ground into fine powder, it is standby；
4) 75% ethanol that bark of tree of heaven, stiff silkworm, Exocarpium Citri Grandis, peach branch, the seed of cowherb, radix glycyrrhizae are added into 5 times of amounts soaks 14 hours,
Filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
5) starch for accounting for well mixed fine powder weight 1/5 is added, is mixed, is pelletized, is dried, whole grain obtains of the application
Granula.
Embodiment 8
Prescription：Garlic 70g, Chinese honey locust (fruit) 23g, Rhizoma Belamcandae 23g, FRUCTUS TERMINALIAE IMMATURUS 10g, carbonized hair 9g, red ginseng 23g, bark of tree of heaven 13g,
Stiff silkworm 10g, Exocarpium Citri Grandis 24g, peach branch 29g, seed of cowherb 12g, radix glycyrrhizae 23g
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by red ginseng, that Crinis carbonisatus powder is broken into fine powder is standby；
3) add 3 times to measure vinegar-fried 14 minutes garlic, Chinese honey locust (fruit), Rhizoma Belamcandae, FRUCTUS TERMINALIAE IMMATURUS, be ground into fine powder, it is standby；
4) 75% ethanol that bark of tree of heaven, stiff silkworm, Exocarpium Citri Grandis, peach branch, the seed of cowherb, radix glycyrrhizae are added into 5 times of amounts soaks 14 hours,
Filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
5) starch for accounting for well mixed fine powder weight 2/5 is added, loads capsule, capsule is made.
Embodiment 9
Prescription：Garlic 65g, Chinese honey locust (fruit) 20g, Rhizoma Belamcandae 20g, FRUCTUS TERMINALIAE IMMATURUS 9g, carbonized hair 8g, red ginseng 20g, bark of tree of heaven 12g, deadlock
Silkworm 9g, Exocarpium Citri Grandis 21g, peach branch 27g, seed of cowherb 11g, radix glycyrrhizae 20g.
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by red ginseng, that Crinis carbonisatus powder is broken into fine powder is standby；
3) add 3 times to measure vinegar-fried 14 minutes garlic, Chinese honey locust (fruit), Rhizoma Belamcandae, FRUCTUS TERMINALIAE IMMATURUS, be ground into fine powder, it is standby；
4) 75% ethanol that bark of tree of heaven, stiff silkworm, Exocarpium Citri Grandis, peach branch, the seed of cowherb, radix glycyrrhizae are added into 5 times of amounts soaks 14 hours,
Filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
5) starch for accounting for well mixed fine powder weight 2/5 is added, loads capsule, capsule is made.
In order to further sketch beneficial effects of the present invention, inventor has done clinical test, specific as follows：
1st, general information：Inventor have collected 315 postpartum abdominal pain patients, age altogether between in January, -2014 in January, 2009
22 years old~39 years old, main performance clinical manifestation was postpartum underbelly severe pain or a few days that has a dull ache is more than, and lochia amount is few, and happiness is by happiness
Rub, dry and hard excrement.
2nd, test method：9 groups are randomly divided into, 1-9 of embodiment of the present invention medicine is taken respectively.Orally, each 3g, one day
Three times, course for the treatment of 10-25 days.
3rd, criterion of therapeutical effect：
It is effective：The clinical symptoms of postpartum abdominal pain all disappear.
Effectively：The clinical symptom relief of postpartum abdominal pain, the state of an illness is controlled.
It is invalid：No significant improvement or aggravated in clinical symptoms for postpartum abdominal pain.
4th, experimental result
Most patients are having the sensation that symptom substantially mitigates in 7 days or so according to the inventive method using medicine, clothes
After 3 weeks, postpartum underbelly severe pain or a few days that has a dull ache are more than, and lochia amount is few, and happiness is rubbed by happiness, and dry and hard excrement the results are shown in Table 1：
The curative effect statistical form of table 1
| Group | It is effective | Effectively | It is invalid | It is total | Efficient (%) |
| Embodiment 1 | 29 | 4 | 2 | 35 | 94.3% |
| Embodiment 2 | 28 | 6 | 1 | 35 | 97.1% |
| Embodiment 3 | 30 | 3 | 2 | 35 | 94.3% |
| Embodiment 4 | 28 | 4 | 3 | 35 | 91.4% |
| Embodiment 5 | 30 | 3 | 2 | 35 | 94.3% |
| Embodiment 6 | 29 | 5 | 1 | 35 | 97.1% |
| Embodiment 7 | 27 | 4 | 4 | 35 | 88.6% |
| Embodiment 8 | 29 | 5 | 1 | 35 | 97.1% |
| Embodiment 9 | 28 | 5 | 2 | 35 | 94.3% |
Postpartum abdominal pain 315 is treated, the efficient average out to 94.3% of each embodiment, effect substantially, and is not found bad
Reaction and toxic side effect, illustrate that pharmaceutical composition of the present invention is evident in efficacy in treatment postpartum abdominal pain, with good promotional value.
Model case：
Mrs Han of case 1, female, 25 years old.Symptom：In 3 days postpartum, because hot summer days covet cool, night does not cover belly, so that impression
Chill, second day underbelly pain, acutely, lochia is poly- only, and soreness of the loins and weakness of the limbs, head dazzles the eyes flower, the medicine of the oral embodiment of the present invention 1 for pain gesture
After thing 4 days, symptom is clearly better, then takes 7 days, and symptom disappears, and recovers.
Mrs Guo of case 2, female, 32 years old, symptom：2 days postpartum underbelly pain, tenderness obtains hot pain and delayed, lochia amount is few, not smooth
Not smooth color purple secretly has to be subtracted bitterly under block, block, and with distending pain in the chest and hypochondrium, the medicine of the oral embodiment of the present invention 2 is after 5 days, and symptom is clearly better,
Take again 7 days, symptom disappears, and recovers.
The Mr. Wang of case 3, female, 26 years old, 5 days postpartum pale complexion, underbelly had a dull ache, and lochia matter is dilute, is QIXUELIANGXU type
Postpartum abdominal pain, the medicine of the oral embodiment of the present invention 3 is after 3 days, and symptom is clearly better, then takes 8 days, and symptom disappears, and recovers.
Case 4 shuts out certain, female, and 31 years old, postpartum underbelly pain subtracted bitterly after rubbing, and often dizzy, palpitaition is seized with terror secondary, diagnosis
For QIXUELIANGXU type postpartum abdominal pain, the medicine of the oral embodiment of the present invention 4 is after 5 days, and symptom is clearly better, then takes 6 days, symptom
Disappear, recover.
The Tan of case 5, female, 36 years old, postpartum abdominal pain, lochia amount was few, and color is light red but without block, is hard and dry, and tongue nature is light, tongue
Bao Bai, arteries and veins is thin and delicate, is diagnosed as QIXUELIANGXU type postpartum abdominal pain.The medicine of the oral embodiment of the present invention 5 is after 6 days, and symptom is substantially good
Turn, then take 6 days, symptom disappears, and recovers.
Lee of case 6, female, 27 years old, there is underbelly pain in 4 days postpartum, and lochia amount is few, and color purple is dim block, discharges not smooth；
The medicine of the oral embodiment of the present invention 6 is after 3 days, and underbelly pain substantially mitigates, and lochia amount is normal, and symptom is clearly better, then takes 6
My god, symptom disappears, and recovers.
The Sun of case 7, female, 29 years old, 5 days postpartum underbelly sharp ache was sustained without reduction and tenderness, few when many during lochia, color
It is purple it is dim lose such as sauce, gas is smelly dirty, red tongue body, yellow and greasy fur, wiry and frequent pulse；The medicine of the oral embodiment of the present invention 7 is after 6 days, and symptom is obvious
Take a turn for the better, then take 8 days, symptom disappears, and recovers.
The Mr. Wang of case 8, female, 38 years old, 4 days postpartum underbelly had a dull ache, and lochia matter is dilute, and tongue nature is light, and tongue is thin white, orally originally
The medicine of inventive embodiments 8 is after 5 days, and symptom is clearly better, then takes 6 days, and symptom disappears, and recovers.
Case 9 thanks certain, female, 28 years old, and underbelly pain occurred in 5 days postpartum, and color purple is dim block, discharges not smooth, red tongue body, tongue
Yellow greasy, the medicine of the oral embodiment of the present invention 9 is after 4 days, and underbelly pain substantially mitigates, and lochia amount is normal, and symptom is clearly better, then
Take 6 days, symptom disappears, and recovers.
Although above having made to retouch in detail to the present invention with general explanation, embodiment and experiment
State, but on the basis of the present invention, some modifications can be made to it or are improved, this is aobvious and easy to those skilled in the art
See.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, are belonged to claimed
Scope.
Claims (10)
1. a kind of pharmaceutical composition for treating postpartum abdominal pain, it is characterised in that the pharmaceutical composition by following parts by weight medicine
It is made：50-80 parts of garlic, 10-30 parts of Chinese honey locust (fruit), 10-30 parts of Rhizoma Belamcandae, 5-13 parts of FRUCTUS TERMINALIAE IMMATURUS, 5-12 parts of carbonized hair, red ginseng
10-30 parts, 8-16 parts of bark of tree of heaven, 5-14 parts of stiff silkworm, 10-30 parts of Exocarpium Citri Grandis, peach branch 15-40 parts, 6-15 parts of the seed of cowherb, radix glycyrrhizae
10-30 parts.
2. pharmaceutical composition according to claim 1, it is characterised in that the pharmaceutical composition by following parts by weight medicine
Thing is made：55-75 parts of garlic, 12-28 parts of Chinese honey locust (fruit), 12-28 parts of Rhizoma Belamcandae, 6-12 parts of FRUCTUS TERMINALIAE IMMATURUS, 6-11 parts of carbonized hair, red ginseng
12-28 parts, 9-15 parts of bark of tree of heaven, 7-12 parts of stiff silkworm, 12-28 parts of Exocarpium Citri Grandis, peach branch 18-35 parts, 7-14 parts of the seed of cowherb, radix glycyrrhizae
12-28 parts.
3. pharmaceutical composition according to claim 2, it is characterised in that the pharmaceutical composition by following parts by weight medicine
Thing is made：58-72 parts of garlic, 15-25 parts of Chinese honey locust (fruit), 15-25 parts of Rhizoma Belamcandae, 7-11 parts of FRUCTUS TERMINALIAE IMMATURUS, 7-10 parts of carbonized hair, red ginseng
15-25 parts, 10-14 parts of bark of tree of heaven, 8-11 parts of stiff silkworm, 15-26 parts of Exocarpium Citri Grandis, peach branch 22-31 parts, 8-13 parts of the seed of cowherb, radix glycyrrhizae
15-25 parts.
4. pharmaceutical composition according to claim 3, it is characterised in that the pharmaceutical composition by following parts by weight medicine
Thing is made：62-70 parts of garlic, 17-23 parts of Chinese honey locust (fruit), 17-23 parts of Rhizoma Belamcandae, 8-10 parts of FRUCTUS TERMINALIAE IMMATURUS, 8-9 parts of carbonized hair, red ginseng
17-23 parts, 11-13 parts of bark of tree of heaven, 9-10 parts of stiff silkworm, 18-24 parts of Exocarpium Citri Grandis, peach branch 24-29 parts, 9-12 parts of the seed of cowherb, radix glycyrrhizae
18-23 parts.
5. pharmaceutical composition according to claim 4, it is characterised in that the pharmaceutical composition by following parts by weight medicine
Thing is made：65 parts of garlic, 20 parts of Chinese honey locust (fruit), 20 parts of Rhizoma Belamcandae, 9 parts of FRUCTUS TERMINALIAE IMMATURUS, 8 parts of carbonized hair, 20 parts of red ginseng, 12 parts of bark of tree of heaven,
9 parts of stiff silkworm, 21 parts of Exocarpium Citri Grandis, 27 parts of peach branch, 11 parts of the seed of cowherb, 20 parts of radix glycyrrhizae.
6. the pharmaceutical composition according to claim any one of 1-5, it is characterised in that the pharmaceutical composition also contains pharmacy
Upper acceptable carrier or diluent.
7. pharmaceutical composition according to claim 6, it is characterised in that described pharmaceutical composition is solid pharmaceutical preparation or liquid
Preparation, the solid pharmaceutical preparation is tablet, capsule, granule or pill；The liquid preparation is oral liquid.
8. a kind of preparation method for preparing the pharmaceutical composition described in claim any one of 1-5, it is characterised in that this method bag
Include following steps：By garlic, Chinese honey locust (fruit), Rhizoma Belamcandae, FRUCTUS TERMINALIAE IMMATURUS, carbonized hair, red ginseng, bark of tree of heaven, stiff silkworm, Exocarpium Citri Grandis, peach branch, king not
Stay row, radix glycyrrhizae to pulverize and sieve, be well mixed with pharmaceutically acceptable carrier or diluent, be prepared into preparation.
9. a kind of preparation method for preparing the pharmaceutical composition described in claim any one of 1-5, it is characterised in that this method bag
Include following steps
1) medicine of parts by weight is weighed respectively, it is standby；
2) by red ginseng, that Crinis carbonisatus powder is broken into fine powder is standby；
3) add 2-5 times to measure vinegar-fried 12-16 minutes garlic, Chinese honey locust (fruit), Rhizoma Belamcandae, FRUCTUS TERMINALIAE IMMATURUS, be ground into fine powder, it is standby；
4) add 3-7 times of 75% ethanol measured immersion 12-16 small bark of tree of heaven, stiff silkworm, Exocarpium Citri Grandis, peach branch, the seed of cowherb, radix glycyrrhizae
When, filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
5) above-mentioned fine powder is well mixed, adds auxiliary material, pharmaceutically acceptable formulation is made.
10. the preparation method of pharmaceutical composition according to claim 9, it is characterised in that this method comprises the following steps：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by red ginseng, that Crinis carbonisatus powder is broken into fine powder is standby；
3) add 3 times to measure vinegar-fried 14 minutes garlic, Chinese honey locust (fruit), Rhizoma Belamcandae, FRUCTUS TERMINALIAE IMMATURUS, be ground into fine powder, it is standby；
4) 75% ethanol that bark of tree of heaven, stiff silkworm, Exocarpium Citri Grandis, peach branch, the seed of cowherb, radix glycyrrhizae are added into 5 times of amounts soaks 14 hours, mistake
Filter, filtrate concentrates, dry, pulverize into fine powder, standby；
5) above-mentioned fine powder is well mixed, adds auxiliary material, pharmaceutically acceptable formulation is made.
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| CN102988736A (en) * | 2012-11-28 | 2013-03-27 | 青岛文创科技有限公司 | Chinese medicinal composition for treating postpartum abdominal pain |
| CN103751482A (en) * | 2014-02-22 | 2014-04-30 | 张利娜 | Medicine for treating postpartum abdominal pain and preparation method thereof |
| CN105148173A (en) * | 2015-07-22 | 2015-12-16 | 当涂县科辉商贸有限公司 | Traditional Chinese medicine decoction for treating postpartum abdominal pain |
| CN105497517A (en) * | 2015-12-31 | 2016-04-20 | 陈彬 | Chinese medicinal composition for treating postpartum abdominal pain due to deficiency of both qi and blood and preparation method thereof |
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| CN102988736A (en) * | 2012-11-28 | 2013-03-27 | 青岛文创科技有限公司 | Chinese medicinal composition for treating postpartum abdominal pain |
| CN103751482A (en) * | 2014-02-22 | 2014-04-30 | 张利娜 | Medicine for treating postpartum abdominal pain and preparation method thereof |
| CN105148173A (en) * | 2015-07-22 | 2015-12-16 | 当涂县科辉商贸有限公司 | Traditional Chinese medicine decoction for treating postpartum abdominal pain |
| CN105497517A (en) * | 2015-12-31 | 2016-04-20 | 陈彬 | Chinese medicinal composition for treating postpartum abdominal pain due to deficiency of both qi and blood and preparation method thereof |
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