CN107913374A - A kind of pharmaceutical composition for treating calculus and preparation method thereof - Google Patents

A kind of pharmaceutical composition for treating calculus and preparation method thereof Download PDF

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Publication number
CN107913374A
CN107913374A CN201711242886.0A CN201711242886A CN107913374A CN 107913374 A CN107913374 A CN 107913374A CN 201711242886 A CN201711242886 A CN 201711242886A CN 107913374 A CN107913374 A CN 107913374A
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parts
pharmaceutical chemicals
bulk pharmaceutical
calculus
final product
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郭博信
黄云
沈晓洲
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Traditional Chinese Medicine Science And Technology (beijing) Ltd By Share Ltd Bosin
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Traditional Chinese Medicine Science And Technology (beijing) Ltd By Share Ltd Bosin
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A61K36/12—Filicopsida or Pteridopsida
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender

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Abstract

The present invention provides a kind of pharmaceutical composition for treating calculus, it is prepared by the bulk pharmaceutical chemicals of following weight proportioning：80 120 parts of reed root, 40 60 parts of rhizoma imperatae, extra large 40 60 parts of gold sand, 40 60 parts of honeysuckle, 24 36 parts of radix bupleuri, 24 36 parts of oriental wormwood, 16 24 parts of desmodium, 8 12 parts of safflower, 8 12 parts of akebi.Present invention also offers the preparation method and purposes of said composition.Composition provided by the invention, compatibility is reasonable, and each flavour of a drug complement each other, and have no toxic side effect, can be small by changing greatly by calculus, by smallization nothing, can effectively treat calculus, has stronger actual application value.

Description

A kind of pharmaceutical composition for treating calculus and preparation method thereof
Technical field
The present invention relates to a kind of pharmaceutical composition for treating calculus and its preparation method and application.
Background technology
Lithiasis is a kind of with a kind of disease caused by calcium salt or lipid accumulation shaping caused by human body abnormal mineralization, is Surgical common disease, including stone in urinary system, Digestive calculus, such as kidney stone, ureteral calculi etc..When calculus is static, patient More without discomfort, once incarceration is very painful.
The traditional Chinese medical science thinks that calculus is not dissipated because internal damp and hot turbid pathogenic factor pents up, and is experienced all sorts of the sandstone sample pathological product for decocting and being formed, is One of Secondary cases cause of disease.It is mainly to cause the kidney and vesical calculus of urolithiasis disease that ancient medicine, which discusses calculus, such as《The General Treatise on the Cause and Symptoms of Diseases All strangurias are waited》Point out：" urolithiasis person, the main water of kidney, water knot then turns to stone, therefore kidney visitor's sandstone, kidney deficiency are multiplied by heat." calculus can occur In many positions of body, using liver and gall, kidney, bladder and stomach to be common.Calculus is the pathological product for having form quality, its is different, Common calculus has silt particle sample calculus, circular or irregular shape calculus etc., and not of uniform size.In general, the small person of calculus, It is easy to discharge；And calculus the greater, it is difficult to discharge, be detained more and cause a disease.
The primary treatment scheme that doctor trained in Western medicine is taken for calculus at present is mostly excising operation and laser lithotripsy.Although this can be Slow down or eliminate the pain of patient in short time, but do not solve the first reason of disease.Because internal hygrothermal environment is simultaneously Do not improve, so most of kidney stone patient needs to do laser lithotripsy operation repeatedly.Like the kettle for making boiling water, water has been grown The mode that we can be manually after dirt dispels incrustation scale, as long as but allow kettle to continue to make boiling water, soon incrustation scale will be again Longer, calculus is also same reason.Therefore, using theory of traditional Chinese medical science as guidance, accurate dialectical, accurate formula, it will be vast Calculus patient bring glad tidings.
The content of the invention
It is an object of the invention to provide a kind of pharmaceutical composition that can effectively treat calculus and its preparation method and application.
The present invention provides a kind of pharmaceutical composition for treating calculus, it be prepared by the bulk pharmaceutical chemicals of following weight proportioning and Into：
80-125 parts of reed root, 35-60 parts of rhizoma imperatae, extra large 35-60 parts of gold sand, 40-60 parts of honeysuckle, 24-36 parts of radix bupleuri, mattress 24-36 parts old, 16-25 parts of desmodium, 7-12 parts of safflower, 7-12 parts of akebi.
Lygodium japonicum：For the drying and ripening spore of Lygodiaceae plant Lygodium japonicum Lygodium japonicum (Thunb.) Sw. Son.
Wherein, it is prepared by the raw material of following weight proportioning：
90-115 parts of reed root, 45-55 parts of rhizoma imperatae, extra large 45-55 parts of gold sand, 45-55 parts of honeysuckle, 28-32 parts of radix bupleuri, mattress 28-32 parts old, 18-22 parts of desmodium, 8-11 parts of safflower, 8-11 parts of akebi.
Wherein, it is prepared by the raw material of following weight proportioning：
100 parts of reed root, 50 parts of rhizoma imperatae, extra large 50 parts of gold sand, 50 parts of honeysuckle, 30 parts of radix bupleuri, 30 parts of oriental wormwood, desmodium 20 Part, 10 parts of safflower, 10 parts of akebi.
Wherein, the composition is with reed root, rhizoma imperatae, extra large gold sand, honeysuckle, radix bupleuri, oriental wormwood, desmodium, safflower, wood Logical medicinal powder, or water or extractive with organic solvent are active ingredient, add pharmaceutically acceptable auxiliary material or complementary component The preparation being prepared.
Pharmaceutically acceptable auxiliary material of the present invention, refers to the material being included in addition to the active ingredient (s in formulation, bag Include but be not limited only to filler (diluent), lubricant (glidant or antitack agent), dispersant, wetting agent, adhesive, adjusting Agent, solubilizer, antioxidant, bacteriostatic agent, emulsifying agent, disintegrant etc..Adhesive include syrup, Arabic gum, gelatin, sorbierite, Tragacanth, cellulose and its derivates (such as microcrystalline cellulose, sodium carboxymethylcellulose, ethyl cellulose or hydroxypropyl methylcellulose Element etc.), gelatine size, syrup, starch slurry or polyvinylpyrrolidone etc.；Filler include lactose, Icing Sugar, dextrin, starch and its Derivative, cellulose and its derivates, inorganic calcium salt (such as calcium sulfate, calcium phosphate, calcium monohydrogen phosphate, precipitated calcium carbonate), sorb Alcohol or glycine etc.；Lubricant includes superfine silica gel powder, magnesium stearate, talcum powder, aluminium hydroxide, boric acid, hydrogenated vegetable oil, poly- second Glycol etc.；Disintegrant includes starch and its derivative (such as sodium carboxymethyl starch, Explotab, pregelatinized starch, improvement shallow lake Powder, hydroxypropul starch, cornstarch etc.), polyvinylpyrrolidone or microcrystalline cellulose etc.；Wetting agent includes dodecyl sulphate Sodium, water or alcohol etc.；Antioxidant packages are containing sodium sulfite, sodium hydrogensulfite, sodium pyrosulfite, dibutyl benzoic acid etc.；Bacteriostatic agent includes 0.5% phenol, 0.3% cresols, 0.5% anesin etc.；Conditioning agent includes hydrochloric acid, citric acid, potassium hydroxide (sodium), citron Sour sodium and buffer (including sodium dihydrogen phosphate and disodium hydrogen phosphate) etc.；Emulsifying agent includes Tween-80, aliphatic acid sorb Smooth, pluronic gram F-68, lecithin, Fabaceous Lecithin etc.；Solubilizer includes Tween-80, bile, glycerine etc..
The pharmaceutically acceptable complementary component, it has certain physiological activity, but the addition of the component will not change Become the leading position of above-claimed cpd or derivative in treatment of diseases, and only play auxiliary effect, these auxiliary work( Effect is only the utilization to the component known activity, is the usual adjuvant treatment modality of field of medicaments.If by it is above-mentioned it is complementary into Divide and be used cooperatively with the compounds of this invention, still should belong to the scope of protection of the invention.
Wherein, the preparation is oral formulations.
Wherein, the oral formulations are decoction, paste, oral liquid, granule, capsule, pill, tablet, powder.
Present invention also offers the preparation method of above-mentioned composition, it includes the following steps：
A, the raw material of each weight proportion is weighed；
Bulk pharmaceutical chemicals are directly beaten to powder, or after adding water or organic solvent extraction, add pharmaceutically acceptable auxiliary material or auxiliary b, Helping property component is prepared.
Water extract is used as medicine with medicinal powder, is Chinese medicine tradition occupation mode, after water carries, since the soluble end of water is wide, and energy Enough by most of active ingredient dissolution, make medicine be easier to be absorbed by the body, work faster, such as the form of medication such as decoction；With Original powder is used as medicine, and the surface area of medicinal powder is larger, is also beneficial to the absorption of active ingredient in vivo in medicinal material, but medicinal material is un-extracted, Active ingredient still needs to the re-absorption of dissolution in vivo, its opposite water extract that works is slower, but also weakens and be harmful into medicinal material at the same time Divide the toxicity caused by human body, be suitable for long-term use, original powder is such as prepared into pill form of medication.At present in pharmacy During, ethanol extracts medicine as solvent, and one of most commonly seen extracting mode, and ethanol is molten for semi-polarity Agent, solubility property circle can dissolve water miscible some components between polarity and nonpolar solvent, can also dissolve nonpolar molten Some components of agent dissolving, usually replace decocting with ethanol extraction, so as to avoid the dissolution of a large amount of invalid components, raising effectively into The concentration and extraction efficiency divided, but the price of ethanol is expensive compared with water, in the big production of modern pharmaceutical industry, is produced into save This, usually or based on decocting.In the case where the water extract of known compositions of the present invention has physiological activity, in order to adapt to Various productions and demand when using, can optionally water carries, original powder, alcohol extracting or combinations thereof method prepare specific agent Type.
Wherein, specific preparation method is as follows：
Tablet：Weigh bulk pharmaceutical chemicals, add water or organic solvent to extract, filtering, filtrate concentration, add auxiliary material or it is complementary into Point, granulation, whole grain, tabletting, to obtain the final product；
Decoction：Bulk pharmaceutical chemicals are weighed, are decocted, filtering, to obtain the final product；
Powder：Weigh bulk pharmaceutical chemicals, beat powder, sieve, to obtain the final product；
Granule：Bulk pharmaceutical chemicals are weighed, add water or organic solvent to extract, filtering, filtrate concentration, dry, addition auxiliary material or auxiliary Helping property component, mixes, granulation, whole grain, drying, to obtain the final product；
Capsule：Bulk pharmaceutical chemicals are weighed, add water or organic solvent to extract, filtering, filtrate is concentrated and dried, and adds auxiliary material or auxiliary Property component, mix, it is encapsulated, to obtain the final product；
The water-bindered pill：Weigh bulk pharmaceutical chemicals, beat powder, sieve, add excipient, water pill is dry, to obtain the final product；
Honeyed bolus：Weigh bulk pharmaceutical chemicals, beat powder, sieve, add honey, pill is dry, to obtain the final product；
Dripping pill：Bulk pharmaceutical chemicals are weighed, adds water or organic solvent to extract, filters, matrix is added in filtrate, mix heating and melting, Instill in not miscible condensate liquid and condense, to obtain the final product.
The organic solvent is the ethanol of various concentrations, such as the ethanol of 25%-95%.
Present invention also offers purposes of the above-mentioned composition in the medicine for preparing treatment calculus.
Wherein, the medicine is the medicine for the treatment of gall stone, kidney stone, vesical calculus or lithangiuria.
Calculus is taken advantage of a weak point mainly due to this void of internal organs, damp and hot turbid pathogenic factor, accumulate smoulder it is poly- do not dissipate, or it is damp and hot decoct with the passing of time and Into.It is often related with diet, feelings will etc..Addiction is pungent, preference for fat and sweet food savoury, or is addicted to drink too, influences transporting and transforming function of the spleen and stomach, and it is wet to accumulate life Heat, interior knot is damp and hot to decoct in courage, with the passing of time can form gall stone；Damp invasion of lower energizer, pents up in lower Jiao, with the passing of time can form kidney or bladder Calculus.Disorder of emotion, stagnation of liver qi, catharsis dereliction of duty, bile excretion is unfavorable and with the passing of time pent-up, retention of dampness due to stagnation of QI blood stasis change heat, hot and suffocating Decoct and form calculus.
In pharmaceutical composition of the present invention, using reed root, rhizoma imperatae as monarch drug in a prescription, clearing heat and promoting fluid, inducing diuresis for treating strangurtia；With extra large gold sand, gold Honeysuckle flower is ministerial drug, clearing heat and detoxicating, clearing and activating the channels and collaterals, is helped with radix bupleuri, oriental wormwood, desmodium, dispersing the stagnated liver-QI and dredging collateral, clearing heat and removing food stagnation, then with safflower, Akebi is to make coordinating the drug actions of a prescription and priming power downlink.
The mechanism of medicine composite for curing calculus of the present invention is：By removing damp-heat from the liver and the gallbladder, change internal hygrothermal environment, Make physical recovery equilibrium state, achieve the purpose that fundamentally to treat calculus；Pharmaceutical composition compatibility of the present invention is reasonable, each flavour of a drug Complement each other, can be small by changing greatly by calculus, by smallization nothing, there is good therapeutic effect to calculus, clinical cure rate is high, and Present composition security is good, has no toxic side effect, easy to use, and a kind of new medicament selection is provided for clinic.
Obviously, the above according to the present invention, according to the ordinary technical knowledge and customary means of this area, is not departing from Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The embodiment of form by the following examples, remakes further specifically the above of the present invention It is bright.But the scope that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following example.It is all to be based on the above of the present invention The technology realized belongs to the scope of the present invention.
Embodiment
It is described further below with embodiment, but the present invention is not limited to these embodiments.
The preparation of 1 medicinal tablet of the present invention of embodiment
Take reed root 100g, rhizoma imperatae 50g, extra large gold sand 50g, honeysuckle 50g, radix bupleuri 30g, oriental wormwood 30g, desmodium 20g, red Flower 10g, akebi 10g, beat powder, direct powder compression, up to tablet.
The preparation of 2 medicinal tablet of the present invention of embodiment
Take reed root 90g, rhizoma imperatae 45g, extra large gold sand 45g, honeysuckle 45g, radix bupleuri 28g, oriental wormwood 32g, desmodium 22g, red Flower 11g, akebi 11g, add water to cook extraction, are condensed into medicinal extract, starch granulation, whole grain, tabletting are added, up to tablet.
The preparation of 3 medicine capsule of the present invention of embodiment
Take reed root 115g, rhizoma imperatae 55g, extra large gold sand 55g, honeysuckle 55g, radix bupleuri 32g, oriental wormwood 28g, desmodium 18g, red Flower 8g, akebi 8g, add water to cook extraction, are condensed into medicinal extract, add auxiliary material, mix, packing, up to capsule.
The preparation of the medicine water-bindered pill of the present invention of embodiment 4
Take reed root 90g, rhizoma imperatae 45g, extra large gold sand 45g, honeysuckle 45g, radix bupleuri 32g, oriental wormwood 32g, desmodium 22g, red Flower 11g, akebi 11g, beat powder, sieve, and add excipient, water pill is dry, up to the water-bindered pill.
The preparation of the medicine honeyed bolus of the present invention of embodiment 5
Take reed root 115g, rhizoma imperatae 55g, extra large gold sand 55g, honeysuckle 55g, radix bupleuri 28g, oriental wormwood 28g, desmodium 18g, red Flower 8g, akebi 8g, beat powder, sieve, and add honey, pill is dry, up to honeyed bolus.
The preparation of the medicine decoction of the present invention of embodiment 6
Take reed root 110g, rhizoma imperatae 45g, extra large gold sand 55g, honeysuckle 50g, radix bupleuri 28g, oriental wormwood 30g, desmodium 20g, red Flower 8g, akebi 9g, soak decoction, merging filtrate, filtering, up to decoction.
The preparation of 7 medicinal tablet of the present invention of embodiment
Take reed root 90g, rhizoma imperatae 55g, extra large gold sand 55g, honeysuckle 45g, radix bupleuri 30g, oriental wormwood 28g, desmodium 22g, red Flower 9g, akebi 9g, are extracted with ethanol, obtain ethanol extract, are condensed into medicinal extract, add starch granulation, whole grain, tabletting, to obtain the final product Tablet.
The preparation of 8 medicine oral liquid of the present invention of embodiment
Take reed root 120g, rhizoma imperatae 60g, extra large gold sand 40g, honeysuckle 45g, radix bupleuri 24g, oriental wormwood 30g, desmodium 24g, red Flower 7g, akebi 12g, soak decoction, merging filtrate, concentration, embedding, sterilizing, up to oral liquid.
Illustrate beneficial effects of the present invention with the mode of test example below：
The clinical efficacy of the medicine composite for curing calculus of the present invention of test example 1
1 experiment material
1.1 experimental drugs pharmaceutical composition of the present invention, is prepared by embodiment 1.
1.2 patient datas observe case totally 46, and the age is 49 years old average.
2 experimental methods
2.1 include case standard：1. being diagnosed as lithangiuria includes kidney stone, ureteral calculi, vesical calculus and urethra The patient of calculus.2. meet cholelithiasis diagnosis patient.
2.2 Excluded cases standards：1. gestation or women breast-feeding their children, those who are allergic to this drug.2. it is associated with angiocarpy, liver, kidney With the severe primary disease such as hemopoietic system, mental patient.3. all do not meet inclusive criteria, not by regulation medication, can not sentence Disconnected curative effect or data be not congruent to affect the treatment or security judgement person.
2.3 curative effects judge
It is effective：After the 1-2 course for the treatment of of taking medicine, sings and symptoms disappears, imageological examination, and calculus disappears.
Effectively：After the 1-2 course for the treatment of of taking medicine, sings and symptoms has mitigation, imageological examination, calculus to reduce or become before relatively treating Small person.
It is invalid：After the 1-2 course for the treatment of of taking medicine, sings and symptoms has mitigation, or unchanged, and imageological examination, calculus is without change Person.
2.4 medication
Medication 2 months：It is 10 days wherein preceding, it is 2-3 times daily, each taking medicine equivalent to 6 grams crude drugs of weight；After 2 times a day, each taking medicine equivalent to 3 grams crude drugs of weight.
3 experimental results
The experiment results show that take 2 months visible positive effects, pharmaceutical composition of the present invention, total effective rate 98%, this hair Bright pharmaceutical composition can effectively treat calculus.
The model case of the medicine composite for curing calculus of the present invention of test example 2
Shen X, women, 45 years old, finds cholecystolithiasis for 2005, and hospital suggests excising one's gallbladder, and patient is reluctant to perform the operation, after take All senses of discomfort eliminations after 50 days of this medicine, cholecystolithiasis is not found after 1 year to Hospital Physical Examination.
To sum up, present composition compatibility is reasonable, has good therapeutic effect to calculus, and clinical cure rate is high, and Present composition security is good, has no toxic side effect, easy to use, and potential applicability in clinical practice is good.

Claims (10)

  1. A kind of 1. pharmaceutical composition for treating calculus, it is characterised in that：It is prepared by the bulk pharmaceutical chemicals of following weight proportioning：
    80-125 parts of reed root, 35-60 parts of rhizoma imperatae, extra large 35-60 parts of gold sand, 40-60 parts of honeysuckle, 24-36 parts of radix bupleuri, oriental wormwood 24-36 parts, 16-25 parts of desmodium, 7-12 parts of safflower, 7-12 parts of akebi.
  2. 2. pharmaceutical composition according to claim 1, it is characterised in that：It is by following weight proportioning raw material prepare and Into：
    90-115 parts of reed root, 45-55 parts of rhizoma imperatae, extra large 45-55 parts of gold sand, 45-55 parts of honeysuckle, 28-32 parts of radix bupleuri, oriental wormwood 28-32 parts, 18-22 parts of desmodium, 8-11 parts of safflower, 8-11 parts of akebi.
  3. 3. pharmaceutical composition according to claim 2, it is characterised in that：It is by following weight proportioning raw material prepare and Into：
    100 parts of reed root, 50 parts of rhizoma imperatae, extra large 50 parts of gold sand, 50 parts of honeysuckle, 30 parts of radix bupleuri, 30 parts of oriental wormwood, 20 parts of desmodium, 10 parts of safflower, 10 parts of akebi.
  4. 4. according to the composition described in claim 1-3 any one, it is characterised in that：The composition is with reed root, cogongrass Root, extra large gold sand, honeysuckle, radix bupleuri, oriental wormwood, desmodium, safflower, the medicinal powder of akebi, or water or extractive with organic solvent are work Property component, adds the preparation that pharmaceutically acceptable auxiliary material or complementary component are prepared.
  5. 5. composition according to claim 4, it is characterised in that：The preparation is oral formulations.
  6. 6. composition according to claim 5, it is characterised in that：The oral formulations for decoction, paste, oral liquid, Granula, capsule, pill, tablet, powder.
  7. 7. the preparation method of the composition described in claim 1-6 any one, it is characterised in that：It includes the following steps：
    A, the raw material of each weight proportion is weighed；
    Bulk pharmaceutical chemicals are directly beaten to powder, or after adding water or organic solvent extraction, add pharmaceutically acceptable auxiliary material or complementary b, Component is prepared.
  8. 8. preparation method according to claim 7, it is characterised in that：Specific preparation method is as follows：
    Tablet：Bulk pharmaceutical chemicals are weighed, add water or organic solvent to extract, filtering, filtrate concentration, add auxiliary material or complementary component, system Grain, whole grain, tabletting, to obtain the final product；
    Decoction：Bulk pharmaceutical chemicals are weighed, are decocted, filtering, to obtain the final product；
    Powder：Weigh bulk pharmaceutical chemicals, beat powder, sieve, to obtain the final product；
    Granule：Bulk pharmaceutical chemicals are weighed, add water or organic solvent to extract, filtering, filtrate concentration, dry, addition auxiliary material or complementary Component, mixes, granulation, whole grain, drying, to obtain the final product；
    Capsule：Weigh bulk pharmaceutical chemicals, add water or organic solvent to extract, filtering, filtrate is concentrated and dried, add auxiliary material or it is complementary into Point, mix, it is encapsulated, to obtain the final product；
    The water-bindered pill：Weigh bulk pharmaceutical chemicals, beat powder, sieve, add excipient, water pill is dry, to obtain the final product；
    Honeyed bolus：Weigh bulk pharmaceutical chemicals, beat powder, sieve, add honey, pill is dry, to obtain the final product；
    Dripping pill：Bulk pharmaceutical chemicals are weighed, adds water or organic solvent to extract, filters, matrix is added in filtrate, mix heating and melting, instill Condensed in not miscible condensate liquid, to obtain the final product.
  9. 9. purposes of the composition in the medicine for preparing treatment calculus described in claim 1-6 any one.
  10. 10. purposes according to claim 9, it is characterised in that：The medicine is treatment gall stone, kidney stone, bladder knot The medicine of stone or lithangiuria.
CN201711242886.0A 2017-11-30 2017-11-30 A kind of pharmaceutical composition for treating calculus and preparation method thereof Pending CN107913374A (en)

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CN108741024A (en) * 2018-05-17 2018-11-06 福建省安溪县苷芝宝食品科技有限公司 A kind of moisture cream that treating kidney stone prolongs slurry and its preparation process

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CN101987187A (en) * 2009-07-31 2011-03-23 天津市公博科技开发有限公司 Formula of Chinese herbal medicine for treating lithiasis
CN104001046A (en) * 2014-05-26 2014-08-27 河南科技大学第一附属医院 Oral traditional Chinese medicine preparation for treating urinary calculus and preparation method thereof
CN104906427A (en) * 2015-06-25 2015-09-16 范家迎 Chinese herbal medicine formula for treating lithiasis

Patent Citations (3)

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CN101987187A (en) * 2009-07-31 2011-03-23 天津市公博科技开发有限公司 Formula of Chinese herbal medicine for treating lithiasis
CN104001046A (en) * 2014-05-26 2014-08-27 河南科技大学第一附属医院 Oral traditional Chinese medicine preparation for treating urinary calculus and preparation method thereof
CN104906427A (en) * 2015-06-25 2015-09-16 范家迎 Chinese herbal medicine formula for treating lithiasis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108741024A (en) * 2018-05-17 2018-11-06 福建省安溪县苷芝宝食品科技有限公司 A kind of moisture cream that treating kidney stone prolongs slurry and its preparation process

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Application publication date: 20180417