CN107875308A - A kind of pharmaceutical composition for treating calculus and its production and use - Google Patents
A kind of pharmaceutical composition for treating calculus and its production and use Download PDFInfo
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Abstract
The invention discloses a kind of pharmaceutical composition, and it is the preparation being prepared by the bulk drug of following weight proportioning:80 120 parts of felwort, 65 100 parts of rhizoma imperatae, 12 28 parts of radix bupleuri, 10 30 parts of the bighead atractylodes rhizome, 8 22 parts of akebi, 5 25 parts of honeysuckle, 6 26 parts of radix achyranthis bidentatae, 5 15 parts of RADIX MORINDAE OFFICINALIS, 5 18 parts of the fruit of glossy privet, 2 10 parts of radix glycyrrhizae.Present invention also offers the preparation method of the pharmaceutical composition and purposes.Clinical test proves that pharmaceutical composition compatibility of the present invention is precise and appropriate, and each taste medicine complements each other, and has no toxic side effect, can be small by changing greatly by calculus, by smallization nothing, can effectively treat calculus, has stronger actual application value.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for treating calculus.
Background technology
Calculus refers in the catheter lumen in body or luminal organ (such as kidney, ureter, gall-bladder, bladder and urethra)
Chamber in the solid mass that is formed.Calculus can betide many positions of body, with hepatic duct, gall-bladder, kidney, bladder, urine output
The position such as pipe and urethra is common.It is composition, shape, quality contained by the mechanism of calculus, right due to the difference of afflicted organ
Influence of body etc. differs.Generally speaking, calculus can cause tube chamber to block, and influence the discharge of afflicted organ's liquid, produce
The symptoms such as pain, bleeding or secondary infection.Disease morbidity urgency, complicated symptoms, complication are more, high recurrence rate and have canceration
May, it is a kind of stubborn disease.
Doctor trained in Western medicine is broken still with operation or external knock wave for the treatment of hepatic calculus, cholecystolithiasis, kidney stone etc. at present
Based on stone art, wherein operative treatment takes stone, major liver resection, gallbladder removal etc. including bile duct stenosis.In recent years, calculus surgery hand
Art curative effect has been significantly improved, but it is postoperative may still face retained calculus, recurrence of hepatolithiasis and again operation etc. problems.
Calculus belongs in the traditional Chinese medical science category of " urolithiasis ", " sand leaching ", " blood strangury ", " stomachache " and " abdominal distension " of " stranguria ", according to facing
Bed research finds that TCM Therapy treatment calculus has the advantages that hurtless measure, adverse reaction are small, cheap and evident in efficacy,
Received at present by numerous calculus patients, especially to some single-shots or little particle calculus, TCM Therapy is into head
Choosing method.Wang Ruifen, " three gold medal Treating Urinary Lithiasis with Paishi Decoction 120, the new traditional Chinese medical science, the 39th phase in 2007 disclose oral three
Golden Paishi Tang (desmodium, the membrane of a chicken's gizzard, curcuma zedoary, Rhizoma Sparganii, extra large gold sand, radix glycyrrhizae, the Radix Astragali, chingma abutilon seed, the seed of cowherb, corydalis tuber, ox
Knee, teasel root, talcum, Chinese herbaceous peony are given, rhizoma alismatis), and routing motion and hydrotherapy can effectively treat stone in urinary system.Application number:
200510010352.6 denomination of invention:A kind of Chinese medicine preparation for treating lithiasis and preparation method thereof, it is mainly with radix bupleuri, life
33 kinds of Chinese herbal medicines such as the root of herbaceous peony, rascal, moutan bark, root tuber of aromatic turmeric, corydalis tuber, extra large gold sand, desmodium and pig gall bladder form through processing;This side
It is high with prodrug complex, drug cost.
Now have no felwort, rhizoma imperatae, radix bupleuri, the bighead atractylodes rhizome, akebi, honeysuckle, radix achyranthis bidentatae, RADIX MORINDAE OFFICINALIS, the fruit of glossy privet and sweet
Grass coordinates the report for treating calculus.
The content of the invention
The invention provides a kind of pharmaceutical composition for treating calculus, and its production and use.
The invention provides a kind of pharmaceutical composition, it is characterised in that:It is prepared by the bulk drug of following weight proportioning
The preparation formed:Felwort 80-120 parts, rhizoma imperatae 65-100 parts, radix bupleuri 12-28 parts, bighead atractylodes rhizome 10-30 parts, akebi 8-22 parts,
Honeysuckle 5-25 parts, radix achyranthis bidentatae 6-26 parts, RADIX MORINDAE OFFICINALIS 5-15 parts, fruit of glossy privet 5-18 parts, radix glycyrrhizae 2-10 parts.
Wherein, it is the preparation being prepared by the bulk drug of following weight proportioning:Felwort 90-110 parts, rhizoma imperatae
70-90 parts, radix bupleuri 15-25 parts, bighead atractylodes rhizome 12-28 parts, akebi 10-20 parts, honeysuckle 8-20 parts, radix achyranthis bidentatae 10-22 parts, RADIX MORINDAE OFFICINALIS
8-12 parts, fruit of glossy privet 6-14 parts, radix glycyrrhizae 4-8 parts.
Wherein, it is the preparation being prepared by the bulk drug of following weight proportioning:100 parts of felwort, 80 parts of rhizoma imperatae,
20 parts of radix bupleuri, 20 parts of the bighead atractylodes rhizome, 15 parts of akebi, 15 parts of honeysuckle, 15 parts of radix achyranthis bidentatae, 10 parts of RADIX MORINDAE OFFICINALIS, 10 parts of the fruit of glossy privet, radix glycyrrhizae 6
Part.
Wherein, described RADIX MORINDAE OFFICINALIS is madder wort Morinda officinalis Morinda officinalis How dry root.
Wherein, the composition be with felwort, rhizoma imperatae, radix bupleuri, the bighead atractylodes rhizome, akebi, honeysuckle, radix achyranthis bidentatae, RADIX MORINDAE OFFICINALIS,
The fruit of glossy privet and the medicinal powder of radix glycyrrhizae, or water or extractive with organic solvent are active ingredient, plus pharmaceutically acceptable auxiliary material system
It is standby into pharmaceutically conventional preparation.
Pharmaceutically acceptable auxiliary material of the present invention, refer to the material being included in addition to the active ingredient (s in formulation, bag
Include but be not limited only to filler (diluent), lubricant (glidant or antitack agent), dispersant, wetting agent, adhesive, regulation
Agent, solubilizer, antioxidant, bacteriostatic agent, emulsifying agent, disintegrant etc..Adhesive include syrup, Arabic gum, gelatin, sorbierite,
Tragacanth, cellulose and its derivates (such as microcrystalline cellulose, sodium carboxymethylcellulose, ethyl cellulose or hydroxypropyl methylcellulose
Element etc.), gelatine size, syrup, starch slurry or polyvinylpyrrolidone etc.;Filler include lactose, Icing Sugar, dextrin, starch and its
Derivative, cellulose and its derivates, inorganic calcium salt (such as calcium sulfate, calcium phosphate, calcium monohydrogen phosphate, precipitated calcium carbonate), sorb
Alcohol or glycine etc.;Lubricant includes superfine silica gel powder, magnesium stearate, talcum powder, aluminium hydroxide, boric acid, hydrogenated vegetable oil, poly- second
Glycol etc.;Disintegrant includes starch and its derivative (such as sodium carboxymethyl starch, Explotab, pregelatinized starch, improvement shallow lake
Powder, hydroxypropul starch, cornstarch etc.), polyvinylpyrrolidone or microcrystalline cellulose etc.;Wetting agent includes dodecyl sulphate
Sodium, water or alcohol etc.;Antioxidant packages are containing sodium sulfite, sodium hydrogensulfite, sodium pyrosulfite, dibutyl benzoic acid etc.;Bacteriostatic agent includes
0.5% phenol, 0.3% cresols, 0.5% anesin etc.;Conditioning agent includes hydrochloric acid, citric acid, potassium hydroxide (sodium), citron
Sour sodium and buffer (including sodium dihydrogen phosphate and disodium hydrogen phosphate) etc.;Emulsifying agent includes Tween-80, aliphatic acid sorb
Smooth, pluronic gram F-68, lecithin, Fabaceous Lecithin etc.;Solubilizer includes Tween-80, bile, glycerine etc..
The pharmaceutically acceptable complementary composition, it has certain physiologically active, but the addition of the composition will not change
Become the leading position of above-claimed cpd or derivative in treatment of diseases, and only play auxiliary effect, these auxiliary work(
Effect is only the utilization to the composition known activity, is the usual adjuvant treatment modality of field of medicaments.If by it is above-mentioned it is complementary into
Divide and be used cooperatively with the compounds of this invention, still should belong to the scope of protection of the invention.
Wherein, the preparation is oral formulations.
Wherein, the preparation is powder, decoction, granule, tablet, capsule, oral liquid, pill.
The present invention also extracts the preparation method of foregoing pharmaceutical composition, and it is comprised the following steps:
(1) bulk drug of each weight proportion is weighed;
(2) bulk drug directly beats powder, or bulk drug is added water to cook or organic solvent extracts, and extract solution concentration, adds
Pharmaceutically acceptable auxiliary material or complementary composition are prepared into pharmaceutically conventional preparation.
Water extract is used as medicine with medicinal powder, is Chinese medicine tradition occupation mode, after water extraction, because the soluble end of water is wide, and energy
Enough by most of active ingredient dissolution, make medicine be easier to be absorbed by the body, work faster, such as the form of medication such as decoction;With
Former powder is used as medicine, and the surface area of medicinal powder is larger, is also beneficial to the absorption of active ingredient in vivo in medicinal material, but medicinal material is un-extracted,
Active ingredient still needs to the re-absorption of dissolution in vivo, and its relative water extract that works is slower, but also weakens and be harmful into medicinal material simultaneously
Divide the toxicity to caused by human body, be suitable for long-term use, former powder is such as prepared into pill form of medication.At present in pharmacy
During, ethanol extracts as solvent to medicine, and one of most commonly seen extracting mode, and ethanol is that semi-polarity is molten
Agent, solubility property circle can dissolve water miscible some compositions between polarity and non-polar solven, can also dissolve nonpolar molten
Some compositions of agent dissolving, generally replace decocting with ethanol extraction, so as to avoid the dissolution of a large amount of invalid components, raising effectively into
The concentration and extraction efficiency divided, but the price of ethanol is expensive compared with water, in the big production of modern pharmaceutical industry, is produced into save
This, generally or based on decocting.In the case where the water extract of known compositions of the present invention has physiologically active, in order to adapt to
Various productions and demand when using, optionally water extraction, former powder, alcohol extracting or combinations thereof method can prepare specific agent
Type.
Wherein, specific preparation method is as follows:
Decoction:Bulk drug is weighed, is decocted, filtering, is produced;
Powder:Bulk drug is weighed, beats powder, sieves, produces;
Granule:Bulk drug is weighed, adds water or organic solvent to extract, filtering, filtrate concentration, dries, adds auxiliary material or auxiliary
Helping property composition, mix, granulation, whole grain, drying, produce;
Tablet:Weigh bulk drug, add water or organic solvent to extract, filtering, filtrate concentration, add auxiliary material or it is complementary into
Point, granulation, whole grain, tabletting, produce;
Capsule:Bulk drug is weighed, adds water or organic solvent to extract, filtering, filtrate is concentrated and dried, and adds auxiliary material or auxiliary
Property composition, mix, it is encapsulated, produce;
The water-bindered pill:Bulk drug is weighed, beats powder, is sieved, excipient is added, water pill, dries, produce;
Honeyed bolus:Bulk drug is weighed, beats powder, is sieved, honey is added, pill, dries, produce;
Dripping pill:Bulk drug is weighed, adds water or organic solvent to extract, filters, matrix is added in filtrate, mix heating and melting,
Instill in not miscible condensate liquid and condense, produce.
Described organic solvent is the ethanol of various concentrations, such as 25%-95% ethanol.
The present invention finally provides purposes of the foregoing pharmaceutical composition in the medicine for preparing treatment calculus.
Wherein, the medicine is the medicine for the treatment of gall stone, kidney stone, vesical calculus or lithangiuria.
Calculus is taken advantage of a weak point mainly due to this void of internal organs, damp and hot turbid pathogenic factor, accumulate smoulder it is poly- do not dissipate, or it is damp and hot decoct with the passing of time and
Into.It is often relevant with diet, feelings will etc..Addiction is pungent, preference for fat and sweet food savoury, or is addicted to drink too, influences transporting and transforming function of the spleen and stomach, and it is wet to accumulate life
Heat, inside tie in courage, it is damp and hot to decoct, it with the passing of time can form gall stone;Damp invasion of lower energizer, pent up in lower Jiao, with the passing of time can form kidney or bladder
Calculus.Disorder of emotion, stagnation of liver qi, catharsis dereliction of duty, bile excretion is unfavorable and with the passing of time pent-up, retention of dampness due to stagnation of QI blood stasis change heat, hot and suffocating
Decoct and form calculus.
In pharmaceutical composition of the present invention, felwort is monarch drug in a prescription, heat-clearing and damp-drying drug, purging the liver of pathogenic fire is calmed the frightened;Rhizoma imperatae, radix bupleuri are ministerial drug,
Reducing fever and causing diuresis, soothing liver-qi stagnation;Assistant is clearing heat and detoxicating with the bighead atractylodes rhizome, akebi, honeysuckle, radix achyranthis bidentatae, inducing diuresis for treating strangurtia;Again with RADIX MORINDAE OFFICINALIS, female
Simultaneously priming power is descending to make coordinating the drug actions of a prescription for loyal son and radix glycyrrhizae.
The mechanism of medicine composite for curing calculus of the present invention is:By removing damp-heat from the liver and the gallbladder, change internal hygrothermal environment,
Make physical recovery poised state, reach the purpose for fundamentally treating calculus;Pharmaceutical composition compatibility of the present invention is precise and appropriate, each taste medicine
Complement each other, have no toxic side effect, can be small by changing greatly by calculus, by smallization nothing, calculus can be effectively treated, has stronger reality should
With value.
Obviously, according to the above of the present invention, according to the ordinary technical knowledge and customary means of this area, do not departing from
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The embodiment of form by the following examples, the above of the present invention is remake further specifically
It is bright.But the scope that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following example.It is all to be based on the above of the present invention
The technology realized belongs to the scope of the present invention.
Embodiment
The preparation of 1 medicinal tablet of the present invention of embodiment
Take felwort 100g, rhizoma imperatae 80g, radix bupleuri 20g, bighead atractylodes rhizome 20g, akebi 15g, honeysuckle 15g, radix achyranthis bidentatae 15g, bar
Halberd meat 10g, fruit of glossy privet 10g, radix glycyrrhizae 6g, beat powder, direct powder compression, produce tablet.Described RADIX MORINDAE OFFICINALIS is madder wort
Morinda officinalis Morinda officinalis How dry root.
The preparation of 2 medicinal tablet of the present invention of embodiment
Take felwort 120g, rhizoma imperatae 100g, radix bupleuri 28g, bighead atractylodes rhizome 30g, akebi 22g, honeysuckle 25g, radix achyranthis bidentatae 26g,
RADIX MORINDAE OFFICINALIS 15g, fruit of glossy privet 18g, radix glycyrrhizae 10g, add water to cook extraction, be condensed into medicinal extract, add starch granulation, whole grain, tabletting, i.e.,
Obtain tablet.Described RADIX MORINDAE OFFICINALIS is madder wort Morinda officinalis Morinda officinalis How dry root.
The preparation of 3 medicine capsule of the present invention of embodiment
Take felwort 80g, rhizoma imperatae 65g, radix bupleuri 12g, bighead atractylodes rhizome 10g, akebi 8g, honeysuckle 5g, radix achyranthis bidentatae 6g, RADIX MORINDAE OFFICINALIS
5g, fruit of glossy privet 5g, radix glycyrrhizae 2g, add water to cook extraction, be condensed into medicinal extract, add auxiliary material, mix, packing, produce capsule.It is described
RADIX MORINDAE OFFICINALIS be madder wort Morinda officinalis Morinda officinalis How dry root.
The preparation of the medicine water-bindered pill of the present invention of embodiment 4
Take felwort 110g, rhizoma imperatae 90g, radix bupleuri 25g, bighead atractylodes rhizome 28g, akebi 20g, honeysuckle 20g, radix achyranthis bidentatae 22g, bar
Halberd meat 12g, fruit of glossy privet 14g, radix glycyrrhizae 8g, beat powder, sieving, add excipient, water pill, dry, produce the water-bindered pill.Described Morinda offcinalis How
Meat is madder wort Morinda officinalis Morinda officinalis How dry root.
The preparation of the medicine honeyed bolus of the present invention of embodiment 5
Take felwort 90g, rhizoma imperatae 70g, radix bupleuri 15g, bighead atractylodes rhizome 12g, akebi 10g, honeysuckle 8g, radix achyranthis bidentatae 10g, Morinda offcinalis How
Meat 8g, fruit of glossy privet 6g, radix glycyrrhizae 4g, beat powder, sieving, add honey, pill, dry, produce honeyed bolus.Described RADIX MORINDAE OFFICINALIS is madder
Section plant Morinda officinalis Morinda officinalis How dry root.
The preparation of the medicine decoction of the present invention of embodiment 6
Take felwort 100g, rhizoma imperatae 80g, radix bupleuri 20g, bighead atractylodes rhizome 20g, akebi 15g, honeysuckle 15g, radix achyranthis bidentatae 15g, bar
Halberd meat 10g, fruit of glossy privet 10g, radix glycyrrhizae 6g, decoction is soaked, merging filtrate, filtering, produces decoction.Described RADIX MORINDAE OFFICINALIS is madder
Careless section plant Morinda officinalis Morinda officinalis How dry root.
The preparation of 7 medicinal tablet of the present invention of embodiment
Take felwort 110g, rhizoma imperatae 90g, radix bupleuri 25g, bighead atractylodes rhizome 28g, akebi 20g, honeysuckle 20g, radix achyranthis bidentatae 22g, bar
Halberd meat 12g, fruit of glossy privet 14g, radix glycyrrhizae 8g, are extracted with ethanol, obtain ethanol extract, are condensed into medicinal extract, are added starch and are pelletized, be whole
Grain, tabletting, produce tablet.Described RADIX MORINDAE OFFICINALIS is madder wort Morinda officinalis Morinda officinalis How drying
Root.
The preparation of 8 medicine oral liquid of the present invention of embodiment
Take felwort 90g, rhizoma imperatae 70g, radix bupleuri 15g, bighead atractylodes rhizome 12g, akebi 10g, honeysuckle 8g, radix achyranthis bidentatae 10g, Morinda offcinalis How
Meat 8g, fruit of glossy privet 6g, radix glycyrrhizae 4g, decoction is soaked, merging filtrate, concentration, embedding, sterilizing, produces oral liquid.Described bar
Halberd meat is madder wort Morinda officinalis Morinda officinalis How dry root.
Beneficial effects of the present invention are proved below by way of specific clinical test:
The clinical efficacy of the medicine composite for curing calculus of the present invention of test example 1
1 experiment material
1.1 Experimental agents pharmaceutical composition of the present invention, is prepared by embodiment 1.
1.2 patient datas observe case totally 38, and the age is average 45 years old.
2 experimental methods
2.1 include case standard:1. being diagnosed as lithangiuria includes kidney stone, ureteral calculi, vesical calculus and urethra
The patient of calculus.2. it is diagnosed as the patient of gall stone.
2.2 Excluded cases standards:1. gestation or women breast-feeding their children, those who are allergic to this drug.2. it is associated with angiocarpy, liver, kidney
With the severe primary disease such as hemopoietic system, mental patient.3. all do not meet inclusive criteria, not by regulation medication, can not sentence
Disconnected curative effect or data be not congruent to affect the treatment or security judgement person.
2.3 curative effects judge
It is effective:After the 1-2 course for the treatment of of taking medicine, sings and symptoms disappears.Imageological examination, calculus disappear.
Effectively:After the 1-2 course for the treatment of of taking medicine, sings and symptoms has mitigation, imageological examination, calculus to reduce or become before relatively treating
Small person.
It is invalid:After the 1-2 course for the treatment of of taking medicine, sings and symptoms has mitigation, or unchanged, and imageological examination, calculus is without change
Person.
2.4 medication
10 days before medication, daily 2-3 times, each taking when need to separate more than half an hour with the meal time, every time
Equivalent to 6 grams crude drugs of the weight for the medicine taken;Later 2 times a day, each taking medicine equivalent to 3 grams crude drugs of weight.
3 experimental results
Experimental result illustrates, takes 3 months visible positive effects, pharmaceutical composition of the present invention, total effective rate 97%, this hair
Bright pharmaceutical composition can effectively treat calculus.
The model case of the medicine composite for curing calculus of the present invention of test example 2
Guo XX, male, 55 years old, kidney stone morbidity in 1998, in great pain, all senses of discomfort disappeared after taking this medicine 40 days
Lose, do not recur again so far.
To sum up, the mechanism of medicine composite for curing calculus of the present invention is:By removing damp-heat from the liver and the gallbladder, change internal damp and hot
Environment, make physical recovery poised state, reach the purpose for fundamentally treating calculus;Pharmaceutical composition compatibility of the present invention is precise and appropriate,
Each taste medicine complements each other, and has no toxic side effect, can be small by changing greatly by calculus, by smallization nothing, can effectively treat calculus, has stronger
Actual application value.
Claims (10)
- A kind of 1. pharmaceutical composition, it is characterised in that:It is the preparation being prepared by the bulk drug of following weight proportioning:Rough gentian Careless 80-120 parts, rhizoma imperatae 65-100 parts, radix bupleuri 12-28 parts, bighead atractylodes rhizome 10-30 parts, akebi 8-22 parts, honeysuckle 5-25 parts, bosom Root of bidentate achyranthes 6-26 parts, RADIX MORINDAE OFFICINALIS 5-15 parts, fruit of glossy privet 5-18 parts, radix glycyrrhizae 2-10 parts.
- 2. pharmaceutical composition according to claim 1, it is characterised in that:It is prepared by the bulk drug of following weight proportioning The preparation formed:Felwort 90-110 parts, rhizoma imperatae 70-90 parts, radix bupleuri 15-25 parts, bighead atractylodes rhizome 12-28 parts, akebi 10-20 parts, Honeysuckle 8-20 parts, radix achyranthis bidentatae 10-22 parts, RADIX MORINDAE OFFICINALIS 8-12 parts, fruit of glossy privet 6-14 parts, radix glycyrrhizae 4-8 parts.
- 3. pharmaceutical composition according to claim 2, it is characterised in that:It is prepared by the bulk drug of following weight proportioning The preparation formed:100 parts of felwort, 80 parts of rhizoma imperatae, 20 parts of radix bupleuri, 20 parts of the bighead atractylodes rhizome, 15 parts of akebi, 15 parts of honeysuckle, bosom ox 15 parts of knee, 10 parts of RADIX MORINDAE OFFICINALIS, 10 parts of the fruit of glossy privet, 6 parts of radix glycyrrhizae.
- 4. according to the pharmaceutical composition described in claim 1-3 any one, it is characterised in that:The composition is with rough gentian Grass, rhizoma imperatae, radix bupleuri, the bighead atractylodes rhizome, akebi, honeysuckle, radix achyranthis bidentatae, RADIX MORINDAE OFFICINALIS, the fruit of glossy privet and the medicinal powder of radix glycyrrhizae, or water or organic Solvent extractable matter is active ingredient, and pharmaceutically conventional preparation is prepared into plus pharmaceutically acceptable auxiliary material.
- 5. pharmaceutical composition according to claim 4, it is characterised in that:The preparation is oral formulations.
- 6. pharmaceutical composition according to claim 5, it is characterised in that:The preparation is powder, decoction, granule, piece Agent, capsule, oral liquid, pill.
- 7. the preparation method of the pharmaceutical composition described in claim 1-6 any one, it is characterised in that:It includes following step Suddenly:(1) bulk drug of each weight proportion is weighed;(2) bulk drug directly beats powder, or bulk drug is added water to cook or organic solvent extracts, and extract solution concentration, adds pharmacy Upper acceptable auxiliary material or complementary composition are prepared into pharmaceutically conventional preparation.
- 8. preparation method according to claim 8, it is characterised in that:Specific preparation method is as follows:Decoction:Bulk drug is weighed, is decocted, filtering, is produced;Powder:Bulk drug is weighed, beats powder, sieves, produces;Granule:Bulk drug is weighed, adds water or organic solvent to extract, filtering, filtrate concentration, dries, adds auxiliary material or complementary Composition, mix, granulation, whole grain, drying, produce;Tablet:Bulk drug is weighed, adds water or organic solvent to extract, filtering, filtrate concentration, adds auxiliary material or complementary composition, system Grain, whole grain, tabletting, are produced;Capsule:Weigh bulk drug, add water or organic solvent to extract, filtering, filtrate is concentrated and dried, add auxiliary material or it is complementary into Point, mix, it is encapsulated, produce;The water-bindered pill:Bulk drug is weighed, beats powder, is sieved, excipient is added, water pill, dries, produce;Honeyed bolus:Bulk drug is weighed, beats powder, is sieved, honey is added, pill, dries, produce;Dripping pill:Bulk drug is weighed, adds water or organic solvent to extract, filters, matrix is added in filtrate, mix heating and melting, instill Condense, produce in not miscible condensate liquid.
- 9. purposes of the pharmaceutical composition in the medicine for preparing treatment calculus described in claim 1-6 any one.
- 10. purposes according to claim 9, it is characterised in that:The medicine is treatment gall stone, kidney stone, bladder knot The medicine of stone or lithangiuria.
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1751734A (en) * | 2005-09-13 | 2006-03-29 | 郭德润 | Traditional Chinese medicine prepn. for treating lithiasis and its prepn. method |
CN101904995A (en) * | 2010-07-28 | 2010-12-08 | 陈帮英 | Traditional Chinese medicine composite for treating biliary calculi |
-
2017
- 2017-11-30 CN CN201711241522.0A patent/CN107875308A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1751734A (en) * | 2005-09-13 | 2006-03-29 | 郭德润 | Traditional Chinese medicine prepn. for treating lithiasis and its prepn. method |
CN101904995A (en) * | 2010-07-28 | 2010-12-08 | 陈帮英 | Traditional Chinese medicine composite for treating biliary calculi |
Non-Patent Citations (2)
Title |
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康广盛等: "《中医名方临床新用》", 31 October 2001, 人民卫生出版社 * |
黄素嫦等: "《中医药治疗泌尿系结石研究述要》", 《中医药学刊》 * |
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