CN107753800A - A kind of Chinese medicine composition for treating chronic pelvic inflammatory disease and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating chronic pelvic inflammatory disease and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of Chinese medicine composition for treating chronic pelvic inflammatory disease and preparation method thereof, the Chinese medicine composition includes 1~3 part of 6~9 parts of dandelion, 5~7 parts of cape jasmine, 4~6 parts of honeysuckle, 3~5 parts of celestial grass, 3~5 parts of coix seed and radix glycyrrhizae.Chinese medicine composition of the present invention has the effect of clearing heat and detoxicating, blood stasis-eliminating and stagnation-dissipating, it can not only be individually used for treating chronic pelvic inflammatory disease, it can be also used in combination with Western medicine, improve curative effect and reduce the toxic side effect of Western medicine, while improve susceptible tired, insomnia, the symptom such as vexed gas is hot-tempered.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for treating chronic pelvic inflammatory disease and its preparation
Method.
Background technology
Chronic pelvic inflammatory disease is a kind of chronic inflammation, is that the connective tissue of female internal genital organs, pelvic peritoneum and surrounding produces
Chronic inflammation.It is mainly shown as abdomen falling inflation pain, leucorrhea increasing, irregular menstruation, salpingemphraxis and secondary infertility etc..It is this
Inflammation is common disease in female population, and frequently-occurring disease, can reach 30~40% incidence of disease.The course of disease is long, disease
Feelings are more obstinate, and some patientss may occur in which that such as lassitude, the whole body are uncomfortable, neurasthenia symptom of having a sleepless night, and have a strong impact on patient's body
Heart health and life.
At present, doctor trained in Western medicine there is no the specific treatment of preferably treatment chronic pelvic inflammatory disease, more using cortin and antibiotic such as
Metronidazole, cefuroxime, lavo-ofloxacin, sulphadiazine etc., although easy recurrence evident in efficacy, and adverse reaction is more,
Toxic side effect is big, is also easy to produce drug resistance, has had a strong impact on the therapeutic quality of patient.In recent years, using traditional Chinese medical herbal treatment
The research of chronic pelvic inflammatory disease achieves greater advance and obtains the attention of gynaecology circle.A large amount of clinical practices prove that the traditional Chinese medical science passes through
Integrally and part is combined, the differentiation of disease is combined with dialectical item, the physical and mental statuse of comprehensive conditioning patient, it is easier to it is accepted by patients,
But the course for the treatment of of the traditional Chinese medical science is longer, take effect relatively slow, it is necessary to which patient, which adheres to taking, could obtain the effect of preferable.
Name of disease of the traditional Chinese medicine without chronic pelvic inflammatory disease, according to its clinical characters, the ownership traditional Chinese medical science " married woman's stomachache ", " vaginal discharge diseases ",
The categories such as " dysmenorrhoea ", " infertility ".Its pathogenic characteristic is damp-heat accumulation, qi depression to blood stasis.The tcm syndrome differentiation and typing of chronic pelvic inflammatory disease
It is clinically more common with 3 types such as qi stagnation and blood stasis type, damp-heat congestion type and cold and damp stagnation types.Chronic pelvic inflammatory disease is in terms of dialectical angle
Have or show or micro- qi depression to blood stasis sign, therefore the promoting flow of qi and blood circulation is to treat the constant method of this disease, or assistant eliminating dampness and heat, or assistant is warm
Change cold-dampness, the effect of certain can be obtained.Chinese patent application CN102805802A discloses a kind of dandelion anti-inflammation pill, and it includes
Radix rehmanniae recen, dandelion, Chinese violet, the radix paeoniae rubrathe, rhizome of chuanxiong, cape jasmine, rascal, Fructus Aurantii, myrrh, the root of herbaceous peony, honeysuckle, Radix Angelicae Sinensis, great burdock achene,
The taste medicine of scutellaria, tangerine core, fritillaria, coptis etc. 20, pelvic infecton can be treated, but the formula flavour of a drug are numerous, are unfavorable for popularization and application.In
State patent application CN104825610A discloses a kind of pharmaceutical composition for treating chronic pelvic inflammatory disease, and it includes radix glycyrrhizae, long-noded pit viper
Tongue grass, Sargent gloryvine, Radix Angelicae Sinensis, the radix paeoniae rubrathe, dandelion, Sculellaria barbata, field pennycress, Ligusticum wallichii, the coptis, lycopodium calvatum, cape jasmine, little Hua caulis sinomeniis, Chinese mugwort
Receive spiceleaf, pteris multifida, radix bupleuri, gratiola, Fructus Aurantii, the root bark of white mulberry, waterplantain ottelia herb, the root of bidentate achyranthes, cassia twig, cyperus awns, the Radix Astragali, honeysuckle, dried orange peel,
The bark of eucommia, the red sage root, radish seed and peach kernel.The formula flavour of a drug are numerous, and cost is high, is equally unfavorable for popularization and application.
Therefore, for treating at present, the Chinese medicine preparation of chronic pelvic inflammatory disease is complicated, curative effect is not good enough, it is necessary to researches and develops a kind of Chinese medicine
Composition, it can not only be individually used for treating chronic pelvic inflammatory disease, can be also used in combination with Western medicine, reduce the toxic side effect of Western medicine,
And improve the symptoms such as the tired, insomnia of patient susceptible.
The content of the invention
In order to solve problems of the prior art (such as formula is complicated, curative effect is not good enough), the invention provides one kind
Treat the Chinese medicine composition of chronic pelvic inflammatory disease, Chinese medicine composition of the present invention easily absorbs, and bioavilability is good, have it is clearing heat and detoxicating,
The effect of blood stasis-eliminating and stagnation-dissipating, it can not only be individually used for treating chronic pelvic inflammatory disease, can be also used in combination with Western medicine, improve curative effect and reduction
The toxic side effect of Western medicine, while improve susceptible tired, insomnia, the symptom such as vexed gas is hot-tempered.
To achieve these goals, technical scheme is as follows：
A kind of Chinese medicine composition for treating chronic pelvic inflammatory disease, include the preparing raw material of following parts by weight meter：Dandelion 6~9
1~3 part of part, 5~7 parts of cape jasmine, 4~6 parts of honeysuckle, 3~5 parts of celestial grass, 3~5 parts of coix seed and radix glycyrrhizae.
As the preferred embodiment of the present invention, the Chinese medicine composition of the treatment chronic pelvic inflammatory disease includes following parts by weight
The preparing raw material of meter：2 parts of 8 parts of dandelion, 6 parts of cape jasmine, 5 parts of honeysuckle, 4 parts of celestial grass, 4 parts of coix seed and radix glycyrrhizae.
Preferably, the Chinese medicine composition is oral formulations.
It is furthermore preferred that the Chinese medicine composition is granule, capsule, oral liquid and pill.
Correspondingly, present invention also offers the preparation method of the Chinese medicine composition of above-mentioned treatment chronic pelvic inflammatory disease, specific bag
Include following steps：
S1, the cape jasmine for taking formula ratio and coix seed, crush, cross 10 mesh sieves, add the water of 4~6 times of medicinal material amounts, immersion 1.5
After~2h, 2~3h of refluxing extraction, filter, filter vacuum is concentrated under reduced pressure into the 1/4~1/3 of original volume, and concentrate A is made；
S2, the dandelion for taking formula ratio, honeysuckle and celestial grass, crush, cross 10 mesh sieves, add the second of 5~7 times of medicinal material amounts
Alcohol, 1~2h of refluxing extraction, filtering, filter vacuum are concentrated under reduced pressure into the 1/4~1/3 of original volume, and concentrate B is made；
S3, the radix glycyrrhizae for taking formula ratio, crush, excessively 10 mesh sieves, the ethanol of 3~5 times of medicinal material amounts of addition, 2~3h of refluxing extraction,
Filtering, filter vacuum are concentrated under reduced pressure into the 1/4~1/3 of original volume, and radix glycyrrhizae concentrate is made；
S4, the concentrate A, concentrate B and radix glycyrrhizae concentrate mixed, mixed liquor is in vacuum-concentrcted at 60 DEG C
Relative density is 1.10~1.20 medicinal extract, is dried under reduced pressure, and is crushed, and the Chinese medicine composition for the treatment of chronic pelvic inflammatory disease is made.
Further, the concentration of volume percent of ethanol is 80~90% in the step S2.
Further, the concentration of volume percent of ethanol is 60~70% in the step S3.
The source of each raw material, nature and flavor and effect are as follows in Chinese medicine composition of the present invention：
Dandelion is feverfew dandelion, dandelion or belongs to the drying herbs of several plants together alkali.It is bitter in taste, sweet,
It is cold.It is clearing heat and detoxicating, diuresis dissipating bind.It is mainly used in furuncle swelling toxin, acute mastitis, scrofula, hot eyes, pharyngalgia, lung carbuncle, acute appendicitis, jaundice with damp-heat pathogen,
Puckery pain of heat gonorrhea etc..
Cape jasmine is the dry mature fruit of madder wort madder.It is bitter in taste, tremble with fear.Purging intense heat relieving restlessness, clearing heat and promoting diuresis, cool blood solution
Poison；Externally used detumescence relieves pain.For Vexed, jaundice with damp-heat pathogen, the puckery pain of stranguria, blood-head tells nosebleed, red eye, swell pain, pathogenic fire,toxin and furuncles, outside
Control bruise pain.
Honeysuckle is caprifoliaceae plant honeysuckle, lonicera hypoglauca miq, the dry flower of Honeysuckle flower (hair calyx honeysuckle or hair style honeysuckle)
Flower bud.Nature and flavor are sweet, tremble with fear.It is clearing heat and detoxicating, wind-heat dissipating.For carbuncle swells furunculosis, larynx numbness, erysipelas, toxic-heat and blood stasis, anemopyretic cold, warm disease
Heating.
Celestial grass is the drying herb of Labiatae Chinese mesona herb platymiscium Chinese mesona herb.Nature and flavor are sweet, light, tremble with fear.Relieve summer heat, heat-clearing, cool blood,
Removing toxic substances.Cure mainly diabetes, jaundice, diarrhea, dysentery, high blood pressure, arthralgia, acute nephritis, acute toothache, burn and scald, pellet
Poison, syphilis.
Coix seed is the dry mature kernal of grass Job's tears.Nature and flavor are sweet, light, cool.Dampness removing heat-clearing, invigorating spleen and reinforcing stomach.
For oedema tinea pedis, deficiency of food diarrhea, arthritis with fixed pain caused by dampness contraction, lung carbuncle, acute appendicitis.
Radix glycyrrhizae is the drying root and rhizome of glycyrrhizic legume, swollen fruit Radix or glycyrrhiza glabra.Nature and flavor are sweet, put down.Tonifying spleen benefit
Gas, cough-relieving apophlegmatic, emergency analgesic therapy, mediation property of medicine.
Dandelion, honeysuckle clearing away heat and eliminating dampeness, diuresis dissipating bind, cape jasmine, celestial grass clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, coix seed dampness removing
Heat-clearing, invigorating spleen and reinforcing stomach, radix glycyrrhizae is invigorated the spleen and benefited qi, emergency analgesic therapy, and coordinating the drug actions of a prescription, all medicines share, plays clearing heat and detoxicating, blood stasis-eliminating and stagnation-dissipating altogether
Effect, have good therapeutic effect to chronic pelvic inflammatory disease, particularly damp-heat congestion type chronic pelvic inflammatory disease.Also, Chinese medicine of the present invention
Composition also has the effect of relieving restlessness that clears away heart-fire, feel at ease to allay excitement, and can improve the symptoms such as patient susceptible is tired, have a sleepless night, vexed gas is hot-tempered, change
Kind sleep quality, improves Abwehrkraft des Koepers, avoids subinfection again or infection scope from spreading.In addition, this Chinese medicine composition is not only
It can be individually used for treating chronic pelvic inflammatory disease, can also can not only improve curative effect, moreover it is possible to protect with Western medicine therapeutic alliance chronic pelvic inflammatory disease
Liver, so as to reduce the toxic side effect of Western medicine.
Therefore, compared with prior art, advantage of the invention is that：
(1) Chinese medicine composition of present invention treatment chronic pelvic inflammatory disease easily absorbs, and bioavilability is high, have it is clearing heat and detoxicating,
Blood stasis-eliminating and stagnation-dissipating, relieving restlessness that clears away heart-fire, the effect of feeling at ease to allay excitement, to chronic pelvic inflammatory disease, particularly damp-heat congestion type chronic pelvic inflammatory disease has very
Good therapeutic effect, and can be used in combination with Western medicine, improve curative effect and reduce the toxic side effect of Western medicine, while improve susceptible tired
Tired, insomnia, the symptom such as vexed gas is hot-tempered, improve sleep quality, improve Abwehrkraft des Koepers, avoid subinfection again or infection scope from expanding
Dissipate.
(2) it is various can be made into granule, oral liquid and pill etc. for the Chinese medicine composition of present invention treatment chronic pelvic inflammatory disease
Peroral dosage form, have a good application prospect；And preparation method is simple, condition is controllable, process stabilizing, can industrialized production, have
Beneficial to popularization and application.
Embodiment
The present invention is further described below by way of specific embodiment, the present invention is not limited only to following examples.In this hair
In bright scope or do not departing from present disclosure, in spirit and scope, the change that is carried out to the present invention, combining or replace
Change, will be apparent to the person skilled in the art, and be included within the scope of the present invention.
Embodiment 1, the Chinese medicine composition of present invention treatment chronic pelvic inflammatory disease and its preparation
Formula：Dandelion 6kg, cape jasmine 5kg, honeysuckle 4kg, celestial grass 3kg, coix seed 3kg and radix glycyrrhizae 1kg.
Preparation method：S1, the cape jasmine for taking formula ratio and coix seed, crush, cross 10 mesh sieves, add 32kg water, soak 1.5h
Afterwards, refluxing extraction 2h, filtering, filter vacuum are concentrated under reduced pressure into the 1/4 of original volume, and concentrate A is made；
S2, the dandelion for taking formula ratio, honeysuckle and celestial grass, crush, cross 10 mesh sieves, add 65kg concentration of volume percent
The 1/4 of original volume is concentrated under reduced pressure into for 80% ethanol, refluxing extraction 1h, filtering, filter vacuum, concentrate B is made；
S3, the radix glycyrrhizae for taking formula ratio, crush, cross 10 mesh sieves, add the ethanol that 3kg concentration of volume percent is 60%, return
Stream extraction 2h, filtering, filter vacuum are concentrated under reduced pressure into the 1/4 of original volume, radix glycyrrhizae concentrate are made；
S4, the concentrate A, concentrate B and radix glycyrrhizae concentrate mixed, mixed liquor is in vacuum-concentrcted at 60 DEG C
Relative density is 1.10 medicinal extract, is dried under reduced pressure, and is crushed, and the Chinese medicine composition for the treatment of chronic pelvic inflammatory disease is made.
According to common process, above-mentioned Chinese medicine composition medicinal powder is mixed with auxiliary materials such as glucose, dry granulation, whole grain, i.e.,
The granule of the Chinese medicine composition of present invention treatment chronic pelvic inflammatory disease is made.
Embodiment 2, the Chinese medicine composition of present invention treatment chronic pelvic inflammatory disease and its preparation
Formula：Dandelion 9kg, cape jasmine 7kg, honeysuckle 6kg, celestial grass 5kg, coix seed 5kg and radix glycyrrhizae 3kg.
Preparation method：S1, the cape jasmine for taking formula ratio and coix seed, crush, cross 10 mesh sieves, add 72kg water, after soaking 2h,
Refluxing extraction 3h, filtering, filter vacuum are concentrated under reduced pressure into the 1/3 of original volume, and concentrate A is made；
S2, the dandelion for taking formula ratio, honeysuckle and celestial grass, crush, cross 10 mesh sieves, it is dense to add 140kg percents by volume
The ethanol for 90% is spent, refluxing extraction 2h, is filtered, filter vacuum is concentrated under reduced pressure into the 1/3 of original volume, and concentrate B is made；
S3, the radix glycyrrhizae for taking formula ratio, crush, cross 10 mesh sieves, add the ethanol that 15kg concentration of volume percent is 70%, return
Stream extraction 2h, filtering, filter vacuum are concentrated under reduced pressure into the 1/3 of original volume, radix glycyrrhizae concentrate are made；
S4, the concentrate A, concentrate B and radix glycyrrhizae concentrate mixed, mixed liquor is in vacuum-concentrcted at 60 DEG C
Relative density is 1.20 medicinal extract, is dried under reduced pressure, and is crushed, and the Chinese medicine composition for the treatment of chronic pelvic inflammatory disease is made.
According to common process, above-mentioned Chinese medicine composition medicinal powder is mixed with auxiliary materials such as glucose, dry granulation, whole grain, i.e.,
The granule of the Chinese medicine composition of present invention treatment chronic pelvic inflammatory disease is made.
Embodiment 3, the Chinese medicine composition of present invention treatment chronic pelvic inflammatory disease and its preparation
Formula：Dandelion 8kg, cape jasmine 6kg, honeysuckle 5kg, celestial grass 4kg, coix seed 4kg and radix glycyrrhizae 2kg.
Preparation method：S1, the cape jasmine for taking formula ratio and coix seed, crush, cross 10 mesh sieves, add 50kg water, after soaking 2h,
Refluxing extraction 2h, filtering, filter vacuum are concentrated under reduced pressure into the 1/4 of original volume, and concentrate A is made；
S2, the dandelion for taking formula ratio, honeysuckle and celestial grass, crush, cross 10 mesh sieves, it is dense to add 102kg percents by volume
The ethanol for 85% is spent, refluxing extraction 1.5h, is filtered, filter vacuum is concentrated under reduced pressure into the 1/4 of original volume, and concentrate B is made；
S3, the radix glycyrrhizae for taking formula ratio, crush, cross 10 mesh sieves, add the ethanol that 8kg concentration of volume percent is 65%, return
Stream extraction 2h, filtering, filter vacuum are concentrated under reduced pressure into the 1/4 of original volume, radix glycyrrhizae concentrate are made；
S4, the concentrate A, concentrate B and radix glycyrrhizae concentrate mixed, mixed liquor is in vacuum-concentrcted at 60 DEG C
Relative density is 1.10 medicinal extract, is dried under reduced pressure, and is crushed, and the Chinese medicine composition for the treatment of chronic pelvic inflammatory disease is made.
According to common process, above-mentioned Chinese medicine composition medicinal powder is mixed with auxiliary materials such as glucose, dry granulation, whole grain, i.e.,
The granule of the Chinese medicine composition of present invention treatment chronic pelvic inflammatory disease is made.
Embodiment 4, the Chinese medicine composition of present invention treatment chronic pelvic inflammatory disease and its preparation
Formula：Dandelion 9kg, cape jasmine 5kg, honeysuckle 4kg, celestial grass 5kg, coix seed 4kg and radix glycyrrhizae 1kg.
Preparation method：S1, the cape jasmine for taking formula ratio and coix seed, crush, cross 10 mesh sieves, add 45kg water, soak 1.5h
Afterwards, refluxing extraction 3h, filtering, filter vacuum are concentrated under reduced pressure into the 1/3 of original volume, and concentrate A is made；
S2, the dandelion for taking formula ratio, honeysuckle and celestial grass, crush, cross 10 mesh sieves, add 90kg concentration of volume percent
The 1/3 of original volume is concentrated under reduced pressure into for 90% ethanol, refluxing extraction 1h, filtering, filter vacuum, concentrate B is made；
S3, the radix glycyrrhizae for taking formula ratio, crush, cross 10 mesh sieves, add the ethanol that 5kg concentration of volume percent is 60%, return
Stream extraction 2h, filtering, filter vacuum are concentrated under reduced pressure into the 1/3 of original volume, radix glycyrrhizae concentrate are made；
S4, the concentrate A, concentrate B and radix glycyrrhizae concentrate mixed, mixed liquor is in vacuum-concentrcted at 60 DEG C
Relative density is 1.10 medicinal extract, is dried under reduced pressure, and is crushed, and the Chinese medicine composition for the treatment of chronic pelvic inflammatory disease is made.
According to common process, above-mentioned Chinese medicine composition medicinal powder is mixed with auxiliary materials such as glucose, dry granulation, whole grain, i.e.,
The granule of the Chinese medicine composition of present invention treatment chronic pelvic inflammatory disease is made.
Embodiment 5, the Chinese medicine composition of present invention treatment chronic pelvic inflammatory disease and its preparation
Formula：Dandelion 8kg, cape jasmine 6kg, honeysuckle 5kg, celestial grass 4kg, coix seed 4kg and radix glycyrrhizae 2kg.
Preparation method：S1, the cape jasmine for taking formula ratio and coix seed, crush, cross 10 mesh sieves, add 50kg water, after soaking 2h,
Refluxing extraction 2h, filtering, filter vacuum are concentrated under reduced pressure into the 1/4 of original volume, and concentrate A is made；
S2, the dandelion for taking formula ratio, honeysuckle and celestial grass, crush, cross 10 mesh sieves, it is dense to add 102kg percents by volume
The ethanol for 85% is spent, refluxing extraction 1.5h, is filtered, filter vacuum is concentrated under reduced pressure into the 1/3 of original volume, and concentrate B is made；
S3, the radix glycyrrhizae for taking formula ratio, crush, cross 10 mesh sieves, add the ethanol that 8kg concentration of volume percent is 65%, return
Stream extraction 2h, filtering, filter vacuum are concentrated under reduced pressure into the 1/3 of original volume, radix glycyrrhizae concentrate are made；
S4, the concentrate A, concentrate B and radix glycyrrhizae concentrate mixed, mixed liquor is in vacuum-concentrcted at 60 DEG C
Relative density is 1.10 medicinal extract, is dried under reduced pressure, and is crushed, and the Chinese medicine composition for the treatment of chronic pelvic inflammatory disease is made.
According to common process, above-mentioned Chinese medicine composition medicinal powder is taken, the volume fraction for adding 3 times of medicinal powder weights is 65% ethanol,
Be sufficiently stirred, stand 24h at room temperature, take supernatant, be recovered under reduced pressure ethanol until supernatant without alcohol taste, obtain decoction；Described in
The water that 6 times of decoction weights are added in decoction is diluted, and the Chinese traditional medicine composition for producing present invention treatment chronic pelvic inflammatory disease is filtered after standing
The oral liquid of thing.
The formula of the Chinese medicine composition of comparative example 1~5 is as follows：
| Raw material | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Comparative example 5 |
| Dandelion | 8kg | 8kg | 8kg | / | 12kg |
| Cape jasmine | 6kg | 6kg | / | 6kg | 6kg |
| Honeysuckle | 5kg | / | 5kg | 5kg | 7kg |
| Celestial grass | 4kg | 4kg | / | 4kg | 4kg |
| Coix seed | / | 4kg | 4kg | / | 6kg |
| Radix glycyrrhizae | / | / | 2kg | 2kg | 2kg |
The preparation method reference implementation example 3 of the Chinese medicine composition of comparative example 1~5, corresponding Chinese medicine composition is made.
Comparative example 6
The formula of this comparative example is the same as embodiment 3.
Preparation method：Compared with Example 3, differ only in：Concentration of volume percent is used in step S2 as 60%
Ethanol is as Extraction solvent；It is 90% ethanol as Extraction solvent that concentration of volume percent is used in step S3.
Comparative example 7
The formula of this comparative example is the same as embodiment 3.
Preparation method：Compared with Example 3, differ only in：It is molten as extracting using water in step S2 and step S3
Agent.
The influence research of test example one, the Chinese medicine composition of present invention treatment chronic pelvic inflammatory disease to liver
1. animal：SPF level Kunming mouses, 18~22g of body weight, male and female half and half, purchased from Guangdong Province medical experiment animal
The heart.
2. medicine and reagent：Lincomycin hydrochloride injection (Tianjin Pharmaceutical Group Xinzheng Co., Ltd.), traditional Chinese medicines are accurate
Word H41021052.The Chinese medicine composition of the embodiment of the present invention 1~4 and the Chinese medicine composition of comparative example 1~7.
3. animal packet and method：Kunming mouse 80,16 groups are randomly divided into, every group 5, gavage is given following respectively
Medicine, common gavage 14d.The in liberal supply drinking-water of the equal whole day of above each group, fasting after 10 points every night, give during next day 8 and fill after gavage
Sufficient feed.Specific packet and dosage regimen are as follows：
Normal group：Physiological saline 20ml/d；
Lincomycin Hydrochloride group：Lincomycin Hydrochloride 0.4ml/d；
1 group of Chinese medicine：The Chinese medicine composition 600mg/ (kgd) of embodiment 1；
2 groups of Chinese medicine：The Chinese medicine composition 600mg/ (kgd) of embodiment 2；
3 groups of Chinese medicine：The Chinese medicine composition 600mg/ (kgd) of embodiment 3；
4 groups of Chinese medicine：The Chinese medicine composition 600mg/ (kgd) of embodiment 4；
Contrast 1 group of Chinese medicine：The Chinese medicine composition 600mg/ (kgd) of comparative example 1；
Contrast 2 groups of Chinese medicine：The Chinese medicine composition 600mg/ (kgd) of comparative example 2；
Contrast 3 groups of Chinese medicine：The Chinese medicine composition 600mg/ (kgd) of comparative example 3；
Contrast 4 groups of Chinese medicine：The Chinese medicine composition 600mg/ (kgd) of comparative example 4；
Contrast 5 groups of Chinese medicine：The Chinese medicine composition 600mg/ (kgd) of comparative example 5；
Contrast 6 groups of Chinese medicine：The Chinese medicine composition 600mg/ (kgd) of comparative example 6；
Contrast 7 groups of Chinese medicine：The Chinese medicine composition 600mg/ (kgd) of comparative example 7；
Chinese medicine+Lincomycin Hydrochloride A groups：The Chinese medicine composition 300mg/ (kgd) of embodiment 3+Lincomycin Hydrochloride
0.4ml/d；
Chinese medicine+Lincomycin Hydrochloride B groups：The Chinese medicine composition 300mg/ (kgd) of comparative example 3+Lincomycin Hydrochloride
0.4ml/d；
Chinese medicine+Lincomycin Hydrochloride C groups：The Chinese medicine composition 300mg/ (kgd) of comparative example 6+Lincomycin Hydrochloride
0.4ml/d。
4. form behavior observation：Observation daily and record each group mouse profile, activity, diet and defecation situation.
5. hepatic pathology inspection：Each group mouse liver is taken, is stayed overnight with being placed after normal saline flushing in 4% paraformaldehyde,
Row HE is dyed, and observes pathology damage.
6. blood analysis：Each group Mouse whole blood is taken to place in anticoagulant tube, blood analyser analysis leucocyte, red blood cell and blood
Platelet etc. counts situation.
7. result：
(1) form behavior situation：
1) normal group, 1 group~4 groups of Chinese medicine, 1 group~7 groups of Chinese medicine of contrast and Chinese medicine+Lincomycin Hydrochloride A group mouse diets
Normally, action is active, and hair flat smooth, excrement is normal, no dead mouse.
2) Chinese medicine+Lincomycin Hydrochloride B groups and Chinese medicine+Lincomycin Hydrochloride C group mouse food ration decline, the state of mind one
As, take action and owe active, dilute soft, no dead mouse of defecating.
3) Lincomycin Hydrochloride group mouse food ration declines, and One's spirits are drooping, behavior is slow, and hair is matt, and chilly is pricked and pushed away,
Defecate dilute wet, no dead mouse.
(2) hepatic pathology observation result：
1) normal group, 1 group~4 groups of Chinese medicine, 2 groups~6 groups of Chinese medicine of contrast and Chinese medicine+Lincomycin Hydrochloride A group Mouse Livers are small
Impeller structure is clear, liver cell rope marshalling, and in reflection shape, sinus hepaticus is normal, and karyon is clear in structure.
2) it is unclear that 1 group of Chinese medicine, contrast 7 groups of mouse lobuli hepatis structures of Chinese medicine are contrasted, hepatic cell cords disorder, liver cell arrangement is gathered around
Squeeze, boundary is unclear, extensive cloudy swelling, the light dye of endochylema, karyon, occurs being dispersed in and becomes with sheet balloon sample, between portal area and liver cell
It can be seen that more inflammatory cell infiltration.
3) Chinese medicine+Lincomycin Hydrochloride A group lobuli hepatis structures are clear, hepatic cell cords marshalling, and in reflection shape, sinus hepaticus is just
Often, karyon is clear in structure, visible between portal area and liver cell to be dispersed in inflammatory cell infiltration.
4) Chinese medicine+Lincomycin Hydrochloride B groups and Chinese medicine+Lincomycin Hydrochloride C group mouse sinus hepaticus dilatation and congestion unobvious, liver
Leaflet structure is unclear, and hepatic cell cords is disorderly, and liver cell arrangement is crowded, and boundary is unclear, extensive cloudy swelling, sees massive inflammatory cells infiltrated
And intracellular silt courage.
5) Lincomycin Hydrochloride group liver parenchyma dilatation and congestion, lobuli hepatis structure is unclear, and hepatic cell cords is disorderly；Liver cell is arranged
Arrange crowded, boundary is unclear, extensive cloudy swelling, the light dye of endochylema, karyon, occurs being dispersed in and sheet balloon sample becomes, it is seen that spotty necrosis and
Inflammatory cell infiltration and intracellular silt courage.
(3) blood analysis result：Each group mouse blood analysis result compares, no difference of science of statistics (P ＞ 0.05).
From the experimental results：1) the Chinese medicine composition continuous gavage 14 of the present invention treatment chronic pelvic inflammatory disease of high dose is given
My god, no dead mouse, mouse form behavior changes without obvious, and liver cell is without exception, illustrates present invention treatment chronic pelvic inflammatory disease
Chinese medicine composition is safe, to liver without obvious toxic-side effects.2) Lincomycin Hydrochloride is to treat commonly using for chronic pelvic inflammatory disease
Medicine, but it can seriously damage liver cell, and combine gavage with the Chinese medicine composition of present invention treatment chronic pelvic inflammatory disease, liver cell
Infringement mitigates, and illustrates the Chinese medicine composition of present invention treatment chronic pelvic inflammatory disease and can mitigate Lincomycin Hydrochloride pair to a certain extent
The detrimental effect of liver.3) compared with Example 3, comparative example 1 lacks some components, and comparative example 7 changes preparation condition, as a result
Its composition has certain infringement to liver cell.4) compared with Example 3, comparative example 3 lacks some components, and comparative example 6 changes
Preparation condition, its composition will not damage liver cell in itself, but can not mitigate infringement of the Lincomycin Hydrochloride to liver and make
With.
The influence research of test example two, the Chinese medicine composition of present invention treatment chronic pelvic inflammatory disease to chronic pelvic inflammatory disease rat
1. animal：SPF level SD rats, female, 200~220g of body weight, 8~12 weeks mouse ages, purchased from Guangdong Province's medical experiment
Animal center.
2. medicine and reagent：Lincomycin hydrochloride injection (Tianjin Pharmaceutical Group Xinzheng Co., Ltd.), traditional Chinese medicines are accurate
Word H41021052.The Chinese medicine composition of the embodiment of the present invention 1~4 and the Chinese medicine composition of comparative example 1~7.
3. method：
(1) modeling method：Chronic pelvic inflammatory disease rat model is established using " Hydroxybenzene mucilage method ".It is 10% hydration chlorine with concentration
Aldehyde intraperitoneal injection of anesthesia rat (0.3ml/100g), after anesthesia comes into force, it is fixed on rubber band drawing four limbs on operating desk, nothing
Rat median incision of lower abdomen about 0.8~1cm is taken under the conditions of bacterium, exposure uterus after abdomen is opened, is carefully entered at the fork of uterus with No. 4 syringe needles
Pin, 25% Hydroxybenzene mucilage 0.04ml is slowly injected into ovary direction respectively, note is finished, and abdomen, sterilization art area are closed in layering.Modeling is postoperative
8d, 5 rats are randomly selected in model group, after 10% chloraldurate 0.3ml/100g intraperitoneal injection of anesthesia rats, take son
Palace tissue makees Pathomorphologic observation.Gross examination of skeletal muscle is shown in uterine tissue and pelvic cavity its hetero-organization has adhesion, and uterine cavity part is narrow, product
Liquid, telangiectasis are congested；Light Microscopic observation is shown in endometrial epithelium and glandular epithelium hyperplasia, and big amount lymphocyte slurry is carefully
Born of the same parents infiltrate, and still see a small amount of neutrophil leucocyte, meet the pathological change of chronic chronic pelvic inflammatory disease, it was demonstrated that modeling success.
(2) animal packet and processing：
Female sd inbred rats 128, after adaptively raising 1 week, random packet, normal group 8, remaining 120 rat are made
Mould, 15 groups are randomly divided into, every group 8, normal group and model control group start to gavage by 20ml/kg body weight doses after modeling 8d
Physiological saline.Other packets and dosage regimen are as follows：
1 group of Chinese medicine：The Chinese medicine composition 200mg/kg of embodiment 1；
2 groups of Chinese medicine：The Chinese medicine composition 200mg/kg of embodiment 2；
3 groups of Chinese medicine：The Chinese medicine composition 200mg/kg of embodiment 4；
Chinese medicine A groups：The Chinese medicine composition 80mg/kg of embodiment 3；
Chinese medicine B groups：The Chinese medicine composition 200mg/kg of embodiment 3；
Chinese medicine C groups：The Chinese medicine composition 400mg/kg of embodiment 3；
Contrast 1 group of Chinese medicine：The Chinese medicine composition 200mg/kg of comparative example 1；
Contrast 2 groups of Chinese medicine：The Chinese medicine composition 200mg/kg of comparative example 2；
Contrast 3 groups of Chinese medicine：The Chinese medicine composition 200mg/kg of comparative example 3；
Contrast 4 groups of Chinese medicine：The Chinese medicine composition 200mg/kg of comparative example 4；
Contrast 5 groups of Chinese medicine：The Chinese medicine composition 200mg/kg of comparative example 5；
Contrast 6 groups of Chinese medicine：The Chinese medicine composition 200mg/kg of comparative example 6；
Contrast 7 groups of Chinese medicine：The Chinese medicine composition 200mg/kg of comparative example 7；
Above each group gavage one time a day, continuous 21d.
(3) Indexs measure：After 10% chloraldurate 0.3ml/100g intraperitoneal injection of anesthesia rats, aortic blood is extracted about
2ml is placed in common test tube, after 4 DEG C stand solidification, low-temperature centrifugation (3500r/min) 15min, is obtained serum, is placed in -20 DEG C of ice
Case preserves, and for determining SOD, MDA content, serum activity of SOD measure uses xanthine oxidase：The μ l of serum 5 are taken, are being divided
OD value is determined at photometer 550nm；Serum MDA measure uses thiobarbituricacidα- method：The μ l of serum 100 are taken, in light splitting light
OD value is determined at degree meter 532nm.
(4) statistical method：Experimental data is represented with mean ± standard deviation, is counted using SPSS17.0 software kits,
Multigroup is compared with variance analysis, compares examined with t two-by-two.
4. result：The expression of various rat blood serum SOD, MDA contents see the table below 1.
The expression of each group rat blood serum SOD, MDA content of table 1
Note：Compared with model control group, * P<0.05, * * P<0.01.
From upper table 1：
1) model control group SOD in serum content is less than normal group, and Content of MDA is higher than normal group, is respectively provided with extremely aobvious
Write difference (P<0.01).
2) embodiment 1, embodiment 2 and the Chinese medicine composition group of embodiment 4, and the Chinese medicine composition of embodiment 3 are basic, normal, high
Dosage group rat blood serum SOD contents are higher than model control group, are respectively provided with notable or pole significant difference (P<0.05 or P<0.01)；It is real
Apply example 2, the Chinese medicine composition group of embodiment 4 and the middle and high dosage group rat blood serum MDA contents of the Chinese medicine composition of embodiment 3 and be less than mould
Type control group, it is respectively provided with notable or pole significant difference (P<0.05 or P<0.01)；The Chinese traditional medicine composition of embodiment 1 and the Chinese medicine of embodiment 3
Composition low dose group rat blood serum MDA contents are less than model control group, but the not notable (P of difference>0.05).
3) in addition to the Chinese medicine composition group of comparative example 6, other comparative example Chinese medicine composition group rat blood serum SOD contents and model
Control group compares, and is not significantly different (P>0.05)；Comparative example Chinese medicine composition group rat blood serum MDA contents and model control group
Compare, be not significantly different (P>0.05).
This experimental study shows：Compared with model control group, the Chinese medicine composition group rat blood serum of the embodiment of the present invention 1~4
SOD contents are significantly raised, Content of MDA substantially reduces, and illustrate that Chinese medicine composition of the present invention can rise to the immunologic function of rat
To adjustment effect.There is the disorder of free radical in chronic pelvic inflammatory disease rat, and use traditional Chinese medicine composition for treating of the present invention, be resistant to tissue
Oxidation, improve local blood circulation and histotrophic nutrition, be advantageous to the dissipation and absorption of rheuminess thing, so as to reach the work for the treatment of
With.
Test example three, the present invention treat the clinical therapeutic efficacy research of the Chinese medicine composition of chronic pelvic inflammatory disease
1. clinical data：
120 volunteers, are diagnosed as damp-heat congestion type chronic pelvic inflammatory disease；30~50 years old age, average age 35 years old；The course of disease
It is most short 6 months, it is most long 6 years；Some patientss are with insomnia simultaneously (course of disease is most short 1 month, most long 3 years).Diagnostic criteria reference《In
Doctor trained in Western medicine clinical gynecology》With《New Chinese medicine guideline of clinical investigations》.Volunteer is randomly divided into 3 groups, respectively western medicine
Group, Chinese herbs group, Chinese medicine+western medicine group.Compare in general information such as age, the courses of disease, three groups of no significant differences
(P>0.05).Exclusion standard：(1) liver anomalies and tumour；(2) serious cardiovascular and cerebrovascular disease；(3) severe mental disturbances；(4) it is right
Its drug administration allergy；(5) compliance is poor.
2. treatment method：
Western medicine group：The lavo-ofloxacin of oral antibiotic, 1 time a day 0.5g, 0.4g metronidazoles 3 times a day, early,
In, evening it is each 1 time.
Chinese herbs group：The Chinese herbal granules of the embodiment of the present invention 3,2 times a day, each 1 time sooner or later, each 10g.
Chinese medicine+western medicine group：The Chinese herbal granules of the embodiment of the present invention 3 are used in combination on the basis of western medicine group,
Dosage and method are constant.
Three groups of patient's treatment time 7d are 1 course for the treatment of, are total up to 4 courses for the treatment of, menstrual period are not disabled.It is right after treatment end
The effect of clinical and symptom are observed.
3. curative effect determinate standard：
Damp-heat congestion type chronic pelvic inflammatory disease：(1) it is effective：Clinical symptoms significantly improve, and every clinical indices inspection has no bright
It is aobvious abnormal；(2) effectively：Clinical symptoms make moderate progress, and every clinical indices inspection has taken a turn for the better；(3) it is invalid：Clinical symptoms are without good
Turn even to deteriorate.
Sleep：(1) it is effective：For nighttime sleep more than 6 hours, sleep is deep；(2) effectively：Nighttime sleep increase by 2 is small
When more than, Depth of sleep increase；(3) it is invalid：Sleep state does not improve after medication.
4. therapeutic effect (is shown in Table 2)
The treatment results of table 2
2 are seen the above table, clinical test results show：
(1) Chinese herbal granules of the embodiment of the present invention 3 have preferable therapeutic effect to damp-heat congestion type chronic pelvic inflammatory disease, always have
Efficiency is 82.5%；Meanwhile the Chinese herbal granules of the embodiment of the present invention 3 can improve insomnia, extend the length of one's sleep, increase sleep is deep
Degree, improves sleep quality, and total effective rate reaches 90%.
(2) compared with western medicine group and Chinese herbs group, Chinese medicine+western medicine group curative effect is more notable, total effective rate
Reach 92.5%, and insomnia can also be improved, total effective rate reaches 90%.Therefore, Chinese medicine composition of the present invention can join with Western medicine
Share in treatment chronic pelvic inflammatory disease, and therapeutic effect is notable, moreover it is possible to improve the symptoms such as patient susceptible is tired, have a sleepless night, vexed gas is hot-tempered.
It the above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair
The limitation of the present invention, protection scope of the present invention should be defined by claim limited range.For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, some improvements and modifications can also be made, these change
Enter and retouch and also should be regarded as protection scope of the present invention.
Claims (7)
1. a kind of Chinese medicine composition for treating chronic pelvic inflammatory disease, it is characterised in that include the preparing raw material of following parts by weight meter：Pu
1~3 part of public 6~9 parts of English, 5~7 parts of cape jasmine, 4~6 parts of honeysuckle, 3~5 parts of celestial grass, 3~5 parts of coix seed and radix glycyrrhizae.
2. the Chinese medicine composition of chronic pelvic inflammatory disease is treated according to claim 1, it is characterised in that including following parts by weight meter
Preparing raw material：2 parts of 8 parts of dandelion, 6 parts of cape jasmine, 5 parts of honeysuckle, 4 parts of celestial grass, 4 parts of coix seed and radix glycyrrhizae.
3. the Chinese medicine composition for the treatment of chronic pelvic inflammatory disease according to claim 1 or claim 2, it is characterised in that the Chinese traditional medicine composition
Thing is oral formulations.
4. the Chinese medicine composition of chronic pelvic inflammatory disease is treated according to claim 3, it is characterised in that the Chinese medicine composition is
Granule, capsule, oral liquid and pill.
5. according to claim 1 treat chronic pelvic inflammatory disease Chinese medicine composition preparation method, it is characterised in that including with
Lower step：
S1, the cape jasmine for taking formula ratio and coix seed, crush, cross 10 mesh sieves, add the water of 4~6 times of medicinal material amounts, soak 1.5~2h
Afterwards, 2~3h of refluxing extraction, filtering, filter vacuum are concentrated under reduced pressure into the 1/4~1/3 of original volume, and concentrate A is made；
S2, the dandelion for taking formula ratio, honeysuckle and celestial grass, crush, cross 10 mesh sieves, add the ethanol of 5~7 times of medicinal material amounts, return
Stream 1~2h of extraction, filtering, filter vacuum are concentrated under reduced pressure into the 1/4~1/3 of original volume, concentrate B are made；
S3, the radix glycyrrhizae for taking formula ratio, crush, cross 10 mesh sieves, add the ethanol of 3~5 times of medicinal material amounts, 2~3h of refluxing extraction, mistake
Filter, filter vacuum are concentrated under reduced pressure into the 1/4~1/3 of original volume, and radix glycyrrhizae concentrate is made；
S4, the concentrate A, concentrate B and radix glycyrrhizae concentrate mixed, mixed liquor is in vacuum-concentrcted to relative at 60 DEG C
Density is 1.10~1.20 medicinal extract, is dried under reduced pressure, and is crushed, and the Chinese medicine composition for the treatment of chronic pelvic inflammatory disease is made.
6. the preparation method of the Chinese medicine composition of chronic pelvic inflammatory disease is treated according to claim 4, it is characterised in that the step
The concentration of volume percent of ethanol is 80~90% in rapid S2.
7. the preparation method of the Chinese medicine composition of chronic pelvic inflammatory disease is treated according to claim 4, it is characterised in that the step
The concentration of volume percent of ethanol is 60~70% in rapid S3.
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| CN103417695A (en) * | 2012-05-18 | 2013-12-04 | 孙冰清 | Traditional Chinese medicine for treating chronic pelvic inflammation |
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| CN103417695A (en) * | 2012-05-18 | 2013-12-04 | 孙冰清 | Traditional Chinese medicine for treating chronic pelvic inflammation |
| CN103446489A (en) * | 2012-05-27 | 2013-12-18 | 孙玉建 | Traditional Chinese medicine for treating acute pelvic inflammatory disease |
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