CN105031065A - Traditional Chinese medicine for treating acute suppurative otitis media and preparation method of traditional Chinese medicine - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for treating acute suppurative otitis media and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine comprises the following raw herbal materials: poisonous boil, laciniate begonia herb, sambucus adnata, rhizoma bolbostemmae, piper hancei, abelmosk, glechoma longituba, semen sojae germinatum, hibiscus tiliaceus, lindera communis, garden balsam seeds, the fruit of rangoon creeper and Ficus pumila L. The traditional Chinese medicine has a definite curative effect for acute suppurative otitis media with slight toxic and side effects by following the theory of traditional Chinese medicine.

Description

A kind of Chinese medicine for the treatment of acute suppurative otitis media and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly a kind of Chinese medicine for the treatment of acute suppurative otitis media and preparation method thereof.

Background technology

Suppurative otitis media is the suppurative inflammation of middle ear mucosa, is apt to occur in child, be also children's's hearing loss commonly encountered diseases because of.Infectious disease common childhood period that acute suppurative otitis media being, sickness rate is high, easily recurs, complication and sequela many.The auxiliary examinations such as otoscopy, ear's palpation contribute to making a definite diagnosis suppurative otitis media.Infection control, adequate drainage, removing the cause of disease is its Therapeutic Principle.

Antibacterial enters to rouse to stop up and causes suppurative infection, is called acute suppurative otitis media, is secondary to upper respiratory tract infection more, and possible some cases is from the beginning of being viral infection, and antibacterial invades thereafter.Common is Hemolytic Type streptococcus, staphylococcus aureus, the IIIth type streptococcus pneumoniae and Bacillus proteus etc.Be more common in winter-spring season, have hematopathy, malnutrition, allergy and heart and lung diseases patient, nephritis, glycosuria patient to be easy to bring out.According to statistics, 5 ~ 16 years old school age population, sickness rate was up to 3%, and within less than 5 years old, person is up to 5% ~ 10%, sometimes can recurrent exerbation repeatedly.Eskimos and American Indian's sickness rate much higher compared with white man, this is caused by ethnic gene or living condition, not yet determines.

Treat acute suppurative otitis media in prior art, with infection control, adequate drainage, removing the cause of disease is its Therapeutic Principle.Apply enough antibiotic or other antibacterials infection controls early, must thoroughly cure.The medicines such as general available penicillins, cephalo-type.As early treatment is proper in time, the perforation of ear drum can be prevented.Get pus after scale perforation and do antibacterial culturing and drug sensitive test.Responsive antibiotic is used instead with reference to its result.Antibiotic need use about 10 days, takes a good rest, dredging stool.General Symptoms severe one gives the supporting treatments such as fluid infusion.Children's's tympanum is thicker, not easily bores a hole, and spread for avoiding infection and can consider myringotomy if desired to intracranial, adequate drainage shortens the course of disease, prevents complication.If when occurring that mastoid air cell melts routed empyema, should row Mastoidotomy in time.Although said method has good therapeutic effect, curative effect is still not good enough, and owing to using antibiotic in a large number, has certain toxic and side effects, and easily recur.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of Chinese medicine for the treatment of acute suppurative otitis media and preparation method thereof, and Chinese medicine of the present invention is to treatment acute suppurative otitis media, and determined curative effect, side effect is little.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of acute suppurative otitis media, described Chinese medicine comprises following raw medicinal material: Herba Violae dissectae, Herba Begoniae Laciniatae, Herba Sambuci Adnatae, Rhizoma Bolbostematis ， Cauliset Folium Piperis Hancei, Radix seu folium abelmoschi moschati, HUOXUEDAN, Semen Glycine Germinatum, Cortex seu flos hibisci tiliacei, Cortex Seu Folium Linderae, Semen Impatientis, Fructus Quisqualis and Fructus Fici Pumilae.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Violae dissectae 10 ~ 20 parts, Herba Begoniae Laciniatae 10 ~ 20 parts, Herba Sambuci Adnatae 15 ~ 25 parts, Rhizoma Bolbostematis 10 ~ 20 parts of ， Cauliset Folium Piperis Hancei 20 ~ 30 parts, Radix seu folium abelmoschi moschati 18 ~ 28 parts, HUOXUEDAN 10 ~ 20 parts, Semen Glycine Germinatum 20 ~ 30 parts, Cortex seu flos hibisci tiliacei 30 ~ 40 parts, Cortex Seu Folium Linderae 10 ~ 20 parts, Semen Impatientis 7 ~ 17 parts, Fructus Quisqualis 5 ~ 15 and Fructus Fici Pumilae 10 ~ 20 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Herba Violae dissectae 15 ~ 20 parts, Herba Begoniae Laciniatae 13 ~ 18 parts, Herba Sambuci Adnatae 17 ~ 22 parts, Rhizoma Bolbostematis 12 ~ 17 parts of ， Cauliset Folium Piperis Hancei 22 ~ 27 parts, Radix seu folium abelmoschi moschati 20 ~ 25 parts, HUOXUEDAN 13 ~ 18 parts, Semen Glycine Germinatum 20 ~ 25 parts, Cortex seu flos hibisci tiliacei 33 ~ 38 parts, Cortex Seu Folium Linderae 15 ~ 20 parts, Semen Impatientis 8 ~ 13 parts, Fructus Quisqualis 6 ~ 11 parts and Fructus Fici Pumilae 13 ~ 18 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Violae dissectae 18 parts, Herba Begoniae Laciniatae 14 parts, Herba Sambuci Adnatae 20 parts, Rhizoma Bolbostematis 13 parts of ， Cauliset Folium Piperis Hancei 26 parts, Radix seu folium abelmoschi moschati 22 parts, HUOXUEDAN 17 parts, Semen Glycine Germinatum 22 parts, Cortex seu flos hibisci tiliacei 36 parts, Cortex Seu Folium Linderae 16 parts, Semen Impatientis 11 parts, Fructus Quisqualis 7 parts and Fructus Fici Pumilae 17 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Violae dissectae 16 parts, Herba Begoniae Laciniatae 17 parts, Herba Sambuci Adnatae 18 parts, Rhizoma Bolbostematis 16 parts of ， Cauliset Folium Piperis Hancei 23 parts, Radix seu folium abelmoschi moschati 25 parts, HUOXUEDAN 14 parts, Semen Glycine Germinatum 24 parts, Cortex seu flos hibisci tiliacei 34 parts, Cortex Seu Folium Linderae 18 parts, Semen Impatientis 9 parts, Fructus Quisqualis 10 parts and Fructus Fici Pumilae 15 parts.

Wherein, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Wherein, when the dosage form of described Chinese medicine is oral liquid, its preparation method comprises the following steps:

The first step, by HUOXUEDAN, Semen Glycine Germinatum, Cortex seu flos hibisci tiliacei, Cortex Seu Folium Linderae, Semen Impatientis, Fructus Quisqualis and Fructus Fici Pumilae mixing, add relative to mixture 3 ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 4 DEG C ~ 10 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

Beneficial effect of the present invention: Chinese medicine provided by the invention, utilizes the theory of Chinese medical science that China is traditional, and to the definite curative effect for the treatment of acute suppurative otitis media, toxic and side effects is little, and instant effect, not easily recur.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of acute suppurative otitis media, described Chinese medicine comprises following raw medicinal material: Herba Violae dissectae, Herba Begoniae Laciniatae, Herba Sambuci Adnatae, Rhizoma Bolbostematis ， Cauliset Folium Piperis Hancei, Radix seu folium abelmoschi moschati, HUOXUEDAN, Semen Glycine Germinatum, Cortex seu flos hibisci tiliacei, Cortex Seu Folium Linderae, Semen Impatientis, Fructus Quisqualis and Fructus Fici Pumilae.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Herba Violae dissectae: [source] medical material Ji Yuan: for Violaceae plants herb or root, the rhizome of special decomposite leaf common violet.Latin plant animal mineral name: VioladissectaLedeb.[nature and flavor] bitter in the mouth; Cold in nature.[return through] heart; Gallbladder; Spleen; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Inducing diuresis and reducing edema.Main furuncle swelling toxin; Measles pyretic toxicity; Pneumonia; Pleuritis; Stranguria with turbid discharge; Leucorrhea; Nephritis.[extracts] " China's book on Chinese herbal medicine "

Herba Begoniae Laciniatae: [another name] Rhizoma Begoniae Fimbristipulatae, tiger spot Caulis et folium euphorbiae milii, Semen Nelumbinis, Herba Lobeliae Chinensis, nine tooth lotuses, Shi Honglian, rock are red, Blood Scolopendra, Rhizoma cypripedii macranthi, Radix et Rhizoma Dysosmatis, red bar fly upward.[source] medical material Ji Yuan: be the herb of Begoniaceae plant Begonia pedatifida.[nature and flavor] sweet in the mouth; Acid; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Main cough due to lung-heat; Furuncle carbuncle; Dysmenorrhea; Amenorrhea; Beriberoid pyretic arthralgia; Treating swelling and pain by traumatic injury; Serpentis flood dragon hinders.[extracts] " China's book on Chinese herbal medicine "

Herba Sambuci Adnatae: [another name] showy reiolaena root-bark, Cortex torricelliae tiliifoliae, blood vessel grass, Ramulus Sambuci Williamsii, severe grass, Red Hill flower, Rhizoma seu Herba Elatostematis stewardii, Margarita fiber crops.[source] medical material Ji Yuan: be mouth herb or the root bark of Ren Ke section plant Herba Sambuci Adnatae.Latin plant animal mineral name: SambucusadnataWall.[nature and flavor] acrid in the mouth; Sweet; Warm in nature.[return through] returns spleen; Kidney channel.[function cures mainly] dispels the wind; Diuretic; Invigorate blood circulation; Dredging collateral.Main acute and chronic nephritis; Rheumatalgia; Rubella pruritus; Children's's single board computer numbness sequela; Chronic lambago and skelalgia; Sprain stasis of blood pain; Fracture.[extracts] " China's book on Chinese herbal medicine "

Rhizoma Bolbostematis: [another name] Rhizoma Bolbostematis, Bulbus Fritillariae Thunbergii, Herba Elephantopi scaberis, careless shellfish, rattan Bulbus Fritillariae Uninbracteatae, base shellfish, pig shellfish repeatly.[source] medical material Ji Yuan: be the bulb of cucurbitaceous plant Bolbostemma paniculatum.[nature and flavor] bitter in the mouth; Cool in nature.[return through] returns lung; Spleen channel.[function cures mainly] removing heat-phlegm; Eliminating stagnation is drawn out pus by applying a plaster to the affected part.Main acute mastitis; Scrofula sucutaneous nodule; Sore swollen toxin; Snakeworm crows wound.[extracts] " China's book on Chinese herbal medicine "

Cauliset Folium Piperis Hancei: [another name] wine cake rattan, Caulis et Folium piperis, 24 diseases, wind of climbing the tree, stone Betel, Cauliset Folium Piperis Hancei, Caulis et Folium piperis, Caulis et Folium piperis, mountain wither green rattan, Fissistigma bracteolatum Chatt., Radix Morindae Officinalis, Fructus Capsici Rhizoma Zingiberis Recens, see that wind chases after, wind of celebrating a festival, Yu Jiefeng, the Serpentis that climbs the tree, embrace Serpentis, water beach wormwood, blood Rhizoma Zingiberis Recens, mountain Lao Ye, also side Seedling.[source] medical material Ji Yuan: be stem and leaf or the root of Piperaceae plant Cauliset Folium Piperis Hancei.[nature and flavor] are pungent; Temperature.[return through] lung; Spleen channel.[function cures mainly] expelling wind and removing dampness; Promoting blood circulation and detumescence; Promoting the circulation of QI to relieve pain; Preventing phlegm from forming and stopping coughing.Main air pain of dampness syndrome; Stomachache; Dysmenorrhea; Traumatic injury; Wind and cold cough with asthma; Colicky.[extracts] " China's book on Chinese herbal medicine "

Radix seu folium abelmoschi moschati: [another name] skirt of thin silk is won, the stasis of blood that blows, false three M.-dodecandrum, wild Hibisci Mutabilis, false Cotton Gossypii, Herba Limnophilae Aromaticae, false Hibisci Mutabilis, medicine Hu, Stone-soil-roller stone roller grass, tripod Trionyx sinensis Wiegmann, tripod break.[source] medical material Ji Yuan: be the Herb of Malvaceae plant Radix seu folium abelmoschi moschati.[nature and flavor] are micro-sweet; Cold in nature.[return through] heart; Lung meridian.[function cures mainly] heat-clearing and toxic substances removing; Stimulating milk secretion relieving constipation.Main hyperpyrexia; Cough due to lung-heat; Dysentery; Constipation; Puerperal galactostasis; Fracture; Carbuncle skin ulcer pus swells; Innominate toxic swelling and water inflammation are scalded.[extracts] " China's book on Chinese herbal medicine "

HUOXUEDAN: [another name] BIANDIXIANG, marchantia, cymbals grass, Herba Glechomae, Hydrocotyle vulgaris L., Bai Ermo, Olibanum rattan, Folium Et Cacumen Murrayae, half Chi Lian, year at noon is cold, money everywhere, money is grass early, money ends, also hoof grass, Radix seu Folium Gaultheriae Forrestii, TOUGUFENG, GUOQIANGFENG, steroid GUFENG, southerner grass, pennyroyal mint, grass through walls, group is through medicine, wind grass, lung-wind syndrome grass, money Herba Menthae, 18 lack grass, HERBA GLECHOMAE, a string money, four directions Gotu Kola, Horse hoof Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Hydrocotyle sibthorpioides lam.Var.Batvachium (Hand.-Mazz.) et shan., to leaf Herba Lysimachiae, infantile malnutrition gets grass, Cortex schizophragmatis integrifolii radicis, synthetism disappears.[source] medical material Ji Yuan: be the herb of labiate HUOXUEDAN.[nature and flavor] bitter in the mouth; Pungent; Cool in nature.[return through] liver; Gallbladder; Urinary bladder channel.[function cures mainly] dampness removing is treating stranguria; Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Main pyretic stranguria stranguria caused by urinary stone; Jaundice due to damp-heat; Sore, carbuncle and painful swelling; Tumbling down damages.[extracts] " China's book on Chinese herbal medicine "

Semen Glycine Germinatum: [another name] sojae germinatum,semen, Semen sojae atricolor tiller, yellow volume, volume tiller, yellow volume skin, bean tiller, Glycine max (L.) Merr. volume, bean tiller.[source] medical material Ji Yuan: form for drying after the germination of legume soybean.[nature and flavor] are sweet; Flat.[return through] spleen; Liver; Stomach warp.[function cures mainly] heat clearing away expelling pathogenic factors from the exterior; Dehumidifying promoting the circulation of QI.Main hygropyrexia from the beginning of; Heat-damp in summer is generated heat; Dyspepsia gastral cavity painful abdominal mass; Arthralgia chiefly caused by damp pathogen; Clonic spasm of the muscle; Arthralgia with restlessness; Edema distension; Dysuria.[extracts] " China's book on Chinese herbal medicine "

Cortex seu flos hibisci tiliacei: [another name] Gang flower, salt water surface folder fruit, Piao son, sea fiber crops, Hai Luoshu, back of a bow tree.[source] medical material Ji Yuan: be the leaf of Malvaceae plant Cortex seu flos hibisci tiliacei, bark or flower.[nature and flavor] are sweet; Light; Cold nature.[return through] lung meridian.[function cures mainly] clearing away lung-heat to relieve cough; Removing toxic substances and promoting subsidence of swelling.Main cough due to lung-heat; Furuncle swells and ache; Manihot poisoning.[extracts] " China's book on Chinese herbal medicine "

Cortex Seu Folium Linderae: [another name] cold and cheerless son, Qian Nianshu, native Ilicis Purpureae, Oleum sesami fruit, Fructus Pyracanthae leaf, little sticky leaf, redwood Rhizoma Zingiberis Recens, Rohdea japonica Roth, bright leaf tree, bright leaf perfume, Emmenopterys henryi oliv., Fructus Linderae Glaucae, glutinous leaf tree, the false Camphor tree of spire, very heavy perfume (or spice), a thousand pieces of gold tree, wild Fructus Litseae pungentis, Cortex Linderae Fragrantis, large Herba Pelargonii Graveolentis, furuncle tree.[source] medical material Ji Yuan: be branch and leaf or the peel of stem of canella Cortex Seu Folium Linderae.[nature and flavor] are puckery; Micro-pungent; Cold nature.[return through] lung; Kidney channel.[function cures mainly] removing toxic substances and promoting subsidence of swelling; Eliminating stasis to stop pain.Main treating swelling and pain by traumatic injury; Traumatic hemorrhage; Carbuncle sore furuncle and phyma.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Semen Impatientis: [another name] buttercup, SEMEN IMPATIENTIS.[source] medical material Ji Yuan: be the seed of Balsaminaceae plant Impatientis.Latin plant animal mineral name: ImpatiensbalsaminaL.[nature and flavor] are pungent; Bitter; Temperature; Mild toxicity.[return through] kidney; Liver; Lung meridian.[function cures mainly] clots absorbing sending down the abnormal ascending QI; Hard masses softening and resolving.Main warp closes; Dysmenorrhea; Dystocia; Retention of placenta in puerperal, dysphagic; Mass in the abdomen; Bone is choked; Dirty tooth; Sore swollen toxin.[extracts] " China's book on Chinese herbal medicine "

Fructus Quisqualis: [another name] stay ask son, history gentleman, five ribs, large rope fruit, winter equal son, sick mandarin orange, Jun Ziren, the winter gentleman, sick infantile malnutrition son.[source] medical material Ji Yuan: be the mature fruit of Combretum Racemosum plant Fructus Quisqualis.Latin plant animal mineral name: QuisqualisindicaL.[nature and flavor] sweet in the mouth; Warm in nature; Mild toxicity.[return through] returns spleen; Stomach warp.[function cures mainly] parasite killing; Removing food stagnancy; Spleen invigorating.Main ascarid stomachache; Infantile malnutrition; Breast food is stagnated; Abdominal distention; Dysentery.[extracts] " China's book on Chinese herbal medicine "

Fructus Fici Pumilae: [another name] Fructus Fici Pumilae, water steamed bread, terrible steamed bread, climing head trailing plants, climb wall fruit, climb wall fruit, Semen Vaccariae, steamed bread Plantula Papaveris, bean jelly fruit, civilian head fruit, literary composition bulky, a sugared steamed bread, Mu Feng, Fructus Citri tangerinae handle, steamed bread youth, terrible ball, Fructus Manglietiae fordianae, bean jelly tree fruit, steamed bread fruit, Fructus Elaeagni Umbellatae, milk Fructus Citri grandis, Cheng Bangzi, wooden really Pu, Ficus prmua L. fruits, bean jelly, Fructus Chaenomelis, wing arm, swollen bubble, Corvus macrorhuchus steamed bread, cook lake.[source] medical material Ji Yuan: be the fruit of moraceae plants Xue Li.Latin plant animal mineral name: FicuspumilaL.[nature and flavor] sweet in the mouth, property are flat.[return through] kidney, stomach, large intestine channel.[function cures mainly] tonifying the kidney to consolidate the essence; Clearing away heat-damp and promoting diuresis; Promoting blood circulation to restore menstrual flow; Lactogenic; Separate detumescence.Main emission due to deficiency of the kidney; YANG disease; Stranguria with turbid discharge; Chronic dysentery; Hemorrhoidal bleeding; Discharging fresh blood stool; Proctoptosis with chronic dysentery; Amenorrhea; Hernia; Agalactia; Throat pain; Mumps; Carbuncle; Scabies.[extracts] " China's book on Chinese herbal medicine "

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Violae dissectae 10 ~ 20 parts, Herba Begoniae Laciniatae 10 ~ 20 parts, Herba Sambuci Adnatae 15 ~ 25 parts, Rhizoma Bolbostematis 10 ~ 20 parts of ， Cauliset Folium Piperis Hancei 20 ~ 30 parts, Radix seu folium abelmoschi moschati 18 ~ 28 parts, HUOXUEDAN 10 ~ 20 parts, Semen Glycine Germinatum 20 ~ 30 parts, Cortex seu flos hibisci tiliacei 30 ~ 40 parts, Cortex Seu Folium Linderae 10 ~ 20 parts, Semen Impatientis 7 ~ 17 parts, Fructus Quisqualis 5 ~ 15 and Fructus Fici Pumilae 10 ~ 20 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Herba Violae dissectae 15 ~ 20 parts, Herba Begoniae Laciniatae 13 ~ 18 parts, Herba Sambuci Adnatae 17 ~ 22 parts, Rhizoma Bolbostematis 12 ~ 17 parts of ， Cauliset Folium Piperis Hancei 22 ~ 27 parts, Radix seu folium abelmoschi moschati 20 ~ 25 parts, HUOXUEDAN 13 ~ 18 parts, Semen Glycine Germinatum 20 ~ 25 parts, Cortex seu flos hibisci tiliacei 33 ~ 38 parts, Cortex Seu Folium Linderae 15 ~ 20 parts, Semen Impatientis 8 ~ 13 parts, Fructus Quisqualis 6 ~ 11 parts and Fructus Fici Pumilae 13 ~ 18 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Violae dissectae 18 parts, Herba Begoniae Laciniatae 14 parts, Herba Sambuci Adnatae 20 parts, Rhizoma Bolbostematis 13 parts of ， Cauliset Folium Piperis Hancei 26 parts, Radix seu folium abelmoschi moschati 22 parts, HUOXUEDAN 17 parts, Semen Glycine Germinatum 22 parts, Cortex seu flos hibisci tiliacei 36 parts, Cortex Seu Folium Linderae 16 parts, Semen Impatientis 11 parts, Fructus Quisqualis 7 parts and Fructus Fici Pumilae 17 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Violae dissectae 16 parts, Herba Begoniae Laciniatae 17 parts, Herba Sambuci Adnatae 18 parts, Rhizoma Bolbostematis 16 parts of ， Cauliset Folium Piperis Hancei 23 parts, Radix seu folium abelmoschi moschati 25 parts, HUOXUEDAN 14 parts, Semen Glycine Germinatum 24 parts, Cortex seu flos hibisci tiliacei 34 parts, Cortex Seu Folium Linderae 18 parts, Semen Impatientis 9 parts, Fructus Quisqualis 10 parts and Fructus Fici Pumilae 15 parts.

Wherein, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Wherein, when the dosage form of described Chinese medicine is oral liquid, its preparation method comprises the following steps:

The first step, by HUOXUEDAN, Semen Glycine Germinatum, Cortex seu flos hibisci tiliacei, Cortex Seu Folium Linderae, Semen Impatientis, Fructus Quisqualis and Fructus Fici Pumilae mixing, add relative to mixture 3 ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 4 DEG C ~ 10 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

Below adopt example to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: capsule

Get Herba Violae dissectae 160g, Herba Begoniae Laciniatae 170g, Herba Sambuci Adnatae 180g, Rhizoma Bolbostematis 160g ， Cauliset Folium Piperis Hancei 230g, Radix seu folium abelmoschi moschati 250g, HUOXUEDAN 140g, Semen Glycine Germinatum 240g, Cortex seu flos hibisci tiliacei 340g, Cortex Seu Folium Linderae 180g, Semen Impatientis 90g, Fructus Quisqualis 100g and Fructus Fici Pumilae 150g;

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 95%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.4:0.3, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Embodiment 2: oral solutions

Get Herba Violae dissectae 180g, Herba Begoniae Laciniatae 140g, Herba Sambuci Adnatae 200g, Rhizoma Bolbostematis 130g ， Cauliset Folium Piperis Hancei 260g, Radix seu folium abelmoschi moschati 220g, HUOXUEDAN 170g, Semen Glycine Germinatum 220g, Cortex seu flos hibisci tiliacei 360g, Cortex Seu Folium Linderae 160g, Semen Impatientis 110g, Fructus Quisqualis 70g and Fructus Fici Pumilae 170g;

Its preparation method comprises the following steps:

The first step, by HUOXUEDAN, Semen Glycine Germinatum, Cortex seu flos hibisci tiliacei, Cortex Seu Folium Linderae, Semen Impatientis, Fructus Quisqualis and Fructus Fici Pumilae mixing, add relative to mixture 5 times amount determining alcohol be 60% alcohol reflux 2 times, each 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 4 times of water gagings, boils 3 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28;

3rd step, the described mastic mixing that the first step, second step are obtained, 65 DEG C of reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 33 hours, and refrigerated storage temperature is 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.17; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.002; The time of described heat treated is 35 minutes, and temperature is 105 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 20 ~ 32g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 1, (concentration is 5.48g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 27.4 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50>27.4 crude drug/kg, every day, maximum dosage-feeding was 54.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.2g crude drug/day/people, adult body weight in 60KG, average dosage is 0.07g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 26g) oral administration gavage Chinese medicine of the present invention is 783 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: the capsule of embodiment 1 prepared by the present invention to 3 groups of rats by 11.26,20.15 and 38.74g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to rat all has no significant effect, and internal organs naked eyes do not find difference change; Histological indications shows, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: whole 100 routine cases are my Out-patient Department patient of in May, 2012 ~ in JIUYUE, 2014, man 55 example, female 45 example, 5 ~ 48 years old age, the course of disease 1 ~ 15 day.Be divided into treatment group and matched group at random, wherein treatment group 50 people, male 27 people, women 23 people, 5 ~ 46 years old age, the course of disease 1 ~ 13 day; Matched group 50 people, male 28 people, women 22 people, 6 ~ 48 years old age, the course of disease 2 ~ 15 days.Two groups in age, sex, clinical manifestation etc. through statistical analysis there was no significant difference (p>0.05).

Diagnostic criteria: morbidity is anxious, and the course of disease is short, patient's multidigit perforation of ear drum, purulent ear, with auditory dysesthesia, can have heating paresthesia and ear deep pain.Ear examination first meeting tympanum is congested, and color is dark red.The then perforation of ear drum, purulent ear.Hearing test shows as transmission deafness.

Exclusion standard: psychiatric disorders patient; Blood or disease of immune system patient; Mismatch the patient of this test.

Therapeutic Method:

Treatment group: dilute external auditory meatus pus with 3% hydrogen peroxide, then blots only with suction pump, every day 1 time.Take the embodiment of the present invention 1 capsule, be grown up each 4, every day 3 times; Each 3 of child, every day 3 times;

Matched group: first dilute external auditory meatus pus with 3% hydrogen peroxide, then blots only with suction pump, then applies levofloxacin ear drop and drips ear, the strong side of patient's head deflection, Ipsilateral, drips 6 ~ 8 upward, holding head invariant position after dripping, is about 10min, every day 2 times; Administration of roxithromycin sheet, be grown up a 150mg, 2 times on the one; Child presses body weight 4mg/kg, 2 times on the one.

Two groups of courses for the treatment of are 7 days.In the 2nd, 4,7 day further consultation record indices.

Curative effect judging standard: cure: clinical symptom disappearance, tympanum color is normal, does not have the congested phenomenon of mucosa, and without any perforation, movable good, do not have pus to secrete, auditory rehabilitation is normal.Effective: cardinal symptom and sign obviously alleviate, tympanum color and activity make moderate progress, tympanum mucosa mild hyperaemia, and pus secretion obviously reduces, and audition is recovered to some extent.Invalid: the famous-brand and high-quality obvious change of sings and symptoms, still have pus to ooze out in auditory meatus, tympanum mucosa is obviously congested, and audition is without any recovery or increase the weight of.

Therapeutic outcome: Comparison of therapeutic situation before and after two groups of patient treatments, in table 1.

Before and after table 1 liang group patient treatment, Comparison of therapeutic situation is as follows:

Group	n	Cure	Effectively	Invalid	Total effective rate
						Treatment group	50	35	13	2	48(96％)
Matched group	50	24	18	8	42(84％)

As shown in Table 1, treatment group curative effect is higher than matched group.

Number and time comparative example (%) is cured after a table 2 liang group treats 2 courses for the treatment of respectively

Group	n	Medication 2 days	Medication 4 days	Medication 7 days
					Treatment group	35	2(4％)	22(44％)	35(70％)
Matched group	24	1(2％)	13(26％)	24(48％)

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, the advantage of safe without toxic side effect; Follow up a case by regular visits to half a year respectively to the 24 routine patients that 35 routine patients and the matched group for the treatment of group healing are cured, result is added up, treatment group 1 case relapsed, and relapse rate is 2.86% simultaneously; The routine patient of matched group 24, recurs 4 people, relapse rate 16.67%.

Concrete case: Wang, female, 21 years old, swimming latter second day, there is property pain once in a while in ear, can alleviate after rubbing, within the 3rd day, the pain increased, and flow out pus, auditory dysesthesia, be admitted to hospital and see a doctor, the congested and perforation of ear examination tympanum, in ear has pus, is diagnosed as acute suppurative otitis media.With 3% hydrogen peroxide, external auditory meatus pus is diluted, then blot only with suction pump, every day 1 time.Take the embodiment of the present invention 1 capsule, each 4, every day 3 times, after taking medicine the 2nd day, infant readme otalgia alleviated, and audition is recovered to some extent, take medicine to the 4th day, the clinical symptom disappearance such as otalgia, tympanum color recovers normal, there is no the congested phenomenon of mucosa, without any perforation, movable good, pus is not had to secrete, auditory rehabilitation is normal, and recovery from illness, follows up a case by regular visits to and do not recur half a year.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat a Chinese medicine for acute suppurative otitis media, it is characterized in that, described Chinese medicine comprises following raw medicinal material: Herba Violae dissectae, Herba Begoniae Laciniatae, Herba Sambuci Adnatae, Rhizoma Bolbostematis, Cauliset Folium Piperis Hancei, Radix seu folium abelmoschi moschati, HUOXUEDAN, Semen Glycine Germinatum, Cortex seu flos hibisci tiliacei, Cortex Seu Folium Linderae, Semen Impatientis, Fructus Quisqualis and Fructus Fici Pumilae.

2. Chinese medicine as claimed in claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae dissectae 10 ~ 20 parts, Herba Begoniae Laciniatae 10 ~ 20 parts, Herba Sambuci Adnatae 15 ~ 25 parts, Rhizoma Bolbostematis 10 ~ 20 parts of Cauliset Folium Piperis Hancei 20 ~ 30 parts, Radix seu folium abelmoschi moschati 18 ~ 28 parts, HUOXUEDAN 10 ~ 20 parts, Semen Glycine Germinatum 20 ~ 30 parts, Cortex seu flos hibisci tiliacei 30 ~ 40 parts, Cortex Seu Folium Linderae 10 ~ 20 parts, Semen Impatientis 7 ~ 17 parts, Fructus Quisqualis 5 ~ 15 and Fructus Fici Pumilae 10 ~ 20 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae dissectae 15 ~ 20 parts, Herba Begoniae Laciniatae 13 ~ 18 parts, Herba Sambuci Adnatae 17 ~ 22 parts, Rhizoma Bolbostematis 12 ~ 17 parts of Cauliset Folium Piperis Hancei 22 ~ 27 parts, Radix seu folium abelmoschi moschati 20 ~ 25 parts, HUOXUEDAN 13 ~ 18 parts, Semen Glycine Germinatum 20 ~ 25 parts, Cortex seu flos hibisci tiliacei 33 ~ 38 parts, Cortex Seu Folium Linderae 15 ~ 20 parts, Semen Impatientis 8 ~ 13 parts, Fructus Quisqualis 6 ~ 11 parts and Fructus Fici Pumilae 13 ~ 18 parts.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae dissectae 18 parts, Herba Begoniae Laciniatae 14 parts, Herba Sambuci Adnatae 20 parts, Rhizoma Bolbostematis 13 parts of Cauliset Folium Piperis Hancei 26 parts, Radix seu folium abelmoschi moschati 22 parts, HUOXUEDAN 17 parts, Semen Glycine Germinatum 22 parts, Cortex seu flos hibisci tiliacei 36 parts, Cortex Seu Folium Linderae 16 parts, Semen Impatientis 11 parts, Fructus Quisqualis 7 parts and Fructus Fici Pumilae 17 parts.

5. the Chinese medicine as described in claims 1 to 3, is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae dissectae 16 parts, Herba Begoniae Laciniatae 17 parts, Herba Sambuci Adnatae 18 parts, Rhizoma Bolbostematis 16 parts of Cauliset Folium Piperis Hancei 23 parts, Radix seu folium abelmoschi moschati 25 parts, HUOXUEDAN 14 parts, Semen Glycine Germinatum 24 parts, Cortex seu flos hibisci tiliacei 34 parts, Cortex Seu Folium Linderae 18 parts, Semen Impatientis 9 parts, Fructus Quisqualis 10 parts and Fructus Fici Pumilae 15 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is oral liquid, and its preparation method comprises the following steps:

The first step, by HUOXUEDAN, Semen Glycine Germinatum, Cortex seu flos hibisci tiliacei, Cortex Seu Folium Linderae, Semen Impatientis, Fructus Quisqualis and Fructus Fici Pumilae mixing, add relative to mixture 3 ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 4 DEG C ~ 10 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

8. the preparation method of Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

9. the preparation method of Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is oral liquid, and its preparation method comprises the following steps:

The first step, by HUOXUEDAN, Semen Glycine Germinatum, Cortex seu flos hibisci tiliacei, Cortex Seu Folium Linderae, Semen Impatientis, Fructus Quisqualis and Fructus Fici Pumilae mixing, add relative to mixture 3 ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 4 DEG C ~ 10 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.