CN105535802A

CN105535802A - Traditional Chinese medicine preparation for treating habitual abortion and preparation method of traditional Chinese medicine preparation

Info

Publication number: CN105535802A
Application number: CN201610131040.9A
Authority: CN
Inventors: 房爱民
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-03-08
Filing date: 2016-03-08
Publication date: 2016-05-04

Abstract

The invention provides a traditional Chinese medicine preparation for treating habitual abortion and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation comprises raw materials as follows: longstamen onion bulb, deer bones, Korean pine seed, wood of largeleaf dogwood, Iris tenuifolia Pall., rhodomyrtus tomentosa, flos magnoliae officinalis, roots of photinia villosa, common perilla, elecampane inula roots, Salvia prionitis Hance, amomum kwangsiense, drynaria fortunei, all-grass of redclawed habenaria, balanophora dioica and common Indian mulberry. The traditional Chinese medicine preparation has the benefits as follows: the traditional Chinese medicine preparation for treating habitual abortion is combined with western medicines for use, is convenient to use and does not have toxic or side effects or cause poor reactions, the cure rate is effectively increased, and the preparation process is simple.

Description

A kind of Chinese medicine preparation for the treatment of habitual abortion and preparation method thereof

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine preparation for the treatment of habitual abortion and preparation method thereof.

Background technology

Habitual abortion, also known as habitual abortion, refers to that spontaneous abortion to recur 3 times or more person, and each miscarriage often occurs in same gestation month.In recent years conventional recurrent spontaneous replaces in the world, and the reason of early abortion is often for luteal phase defect, hypothyroidism, chromosomal abnormality, the modal reason of late abortion are cervical opening relaxation, uterine malformation, hysteromyoma etc.The clinical manifestation of habitual abortion with generally miscarry identical, be also experience threatened abortion, inevitable abortion, not entirely or artificial abortion several stage.Only can show as vagina in early days hemorrhage a little, or have the hidden pain of slight lower abdomen, the bleeding time can last for days or several weeks, and blood volume is less.Once vaginal hemorrhage is increased, abdomen pain increases the weight of, and checks the existing expansion of cervix uteri mouth, during even visible foetal sac blocking eck, miscarries inevitable.As pregnant thing is all discharged, be called artificial abortion; Only the pregnant thing of part is discharged, and when still having part to remain in cavity of uterus, is called incomplete abortion, needs clearing heat in the pericardium process immediately.After habitual abortion occurs, couple should go to regular hospital or family planning service station to be checked, and find out the reason causing " miscarriage ", symptomatic treatment.

Habitual abortion belongs to the category of Chinese medicine " habitual abortion ".Ming Dynasty's " Jing Yue's complete work married woman rule " proposes " see abortion repeatly, abortionist, how between three months and May, July, and under take second place fall must be so multiple as scheduled " habitual abortion phenomenon.Motherland's medical science is thought: the kidney being the origin of congenital constitution, kidney storing essence, blood stored in the liver, The spleen has the function to transport and transform nutrients, Liver and kidney for punching appoint this, deficiency of the liver and kindey, the then debility of CHONG and REN meridians, will tire to become homeless be cause vaginal bleeding during pregnancy, the spleen being the foundation of acquired constitution, the source of vital function, weakness of the spleen and stomach then changes source deficiency, and tire is become homeless foster, and spleen kidney provides as use mutually, the spleen reinforcing therefore the kidney invigorating is held concurrently, insufficiency of vital energy and blood also can be become homeless foster by tire.The liver losing its smoothly moving state, depressed heat-transformation also can lose tire without, and cause frequent fetal movement and vaginal bleeding during pregnancy.The formation of primary disease and the factor such as exhaustion due to sexual indulgence fecund, surfeit pungent, injury from falling down, natural endowment weakness, eating and drinking without temperance cause suffer from a deficiency of the kidney, the debility of CHONG and REN meridians, tire is become homeless and is, and insufficiency of the spleen insufficiency of generating and transforming QI and blood, and tire is become homeless foster; Injury from falling down, the factor relations such as straight wound punching is appointed, feotus vitality are close.

Summary of the invention

Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides a kind of determined curative effect and Chinese medicine preparation of the little treatment habitual abortion of toxic action and preparation method thereof.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of habitual abortion, described Chinese medicine preparation comprises following raw medicinal material: Bulbus Allii Macrostemonis, Os Cervi, Semen pini koraiensis, Lignum corni macrophyllae, old cattle are carried, Fructus Rhodomyrti, Flos Magnoliae Officinalis, hair leaf Chinese photinia, common perilla, Radix Inulae, Arisaema balansae Engl. grass, native Fructus Tsaoko, Rhizoma Drynariae, kidney channel grass, Cor Cervi are careless and Radix Morindae Umbellatae.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Bulbus Allii Macrostemonis 25 ~ 35 parts, Os Cervi 10 ~ 20 parts, Semen pini koraiensis 15 ~ 25 parts, Lignum corni macrophyllae 15 ~ 30 parts, old cattle carries 5 ~ 15 parts, Fructus Rhodomyrti 20 ~ 30 parts, Flos Magnoliae Officinalis 15 ~ 25 parts, hair leaf Chinese photinia 5 ~ 15 parts, common perilla 30 ~ 40 parts, Radix Inulae 25 ~ 35 parts, Arisaema balansae Engl. grass 10 ~ 20 parts, soil Fructus Tsaoko 15 ~ 30 parts, Rhizoma Drynariae 20 ~ 30 parts, kidney channel grass 15 ~ 25 parts, Cor Cervi grass 10 ~ 20 parts and Radix Morindae Umbellatae 25 ~ 35 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also more preferably: Bulbus Allii Macrostemonis 25 ~ 30 parts, Os Cervi 10 ~ 15 parts, Semen pini koraiensis 20 ~ 25 parts, Lignum corni macrophyllae 15 ~ 20 parts, old cattle carries 10 ~ 15 parts, Fructus Rhodomyrti 25 ~ 30 parts, Flos Magnoliae Officinalis 20 ~ 25 parts, hair leaf Chinese photinia 5 ~ 10 parts, common perilla 35 ~ 40 parts, Radix Inulae 25 ~ 30 parts, Arisaema balansae Engl. grass 10 ~ 15 parts, soil Fructus Tsaoko 20 ~ 25 parts, Rhizoma Drynariae 25 ~ 30 parts, kidney channel grass 15 ~ 20 parts, Cor Cervi grass 10 ~ 15 parts and Radix Morindae Umbellatae 30 ~ 35 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation also can more preferably: Bulbus Allii Macrostemonis 26 parts, Os Cervi 15 parts, Semen pini koraiensis 21 parts, Lignum corni macrophyllae 19 parts, old cattle carry 12 parts, Fructus Rhodomyrti 28 parts, Flos Magnoliae Officinalis 21 part, mao leaf Chinese photinia 9 parts, common perilla 37 parts, Radix Inulae 29 parts, Arisaema balansae Engl. grass 12 parts, native Fructus Tsaoko 25 parts, Rhizoma Drynariae 27 parts, kidney channel grass 19 parts, Cor Cervi grass 12 parts and Radix Morindae Umbellatae 35 parts.

When the dosage form of described Chinese medicine preparation is oral solutions, its preparation method comprises the following steps:

The first step, Bulbus Allii Macrostemonis, Os Cervi, Semen pini koraiensis, Lignum corni macrophyllae, old cattle are carried, Fructus Rhodomyrti, Flos Magnoliae Officinalis, hair leaf Chinese photinia and common perilla be mixed in proportion, be that the methanol of 70% ~ 80% is as solvent with determining alcohol, adopt percolation with the speed of 1 ~ 3ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder; The quality of the methanol added is 4 ~ 6 times of first step mixture quality;

Second step, is mixed in proportion surplus stock medical material, is ground into powder; Add the distilled water of the powder quality 4 ~ 6 times obtained relative to second step, decoct 2 ~ 4 hours, filter, obtain the first filtrate; Filtering residue is added the distilled water relative to its quality 2 ~ 4 times, decoct 1 ~ 3 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 ~ 3/4 volume, add the ethanol that determining alcohol is 90 ~ 95%, make determining alcohol reach 70% ~ 80%, leave standstill 20 ~ 40 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;

3rd step, the powder mixing first step and second step obtained, add the distilled water relative to powder quality 3 ~ 5 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.03 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

When the dosage form of described Chinese medicine preparation is tablet, its preparation method comprises the following steps:

The first step, Bulbus Allii Macrostemonis, Os Cervi, Semen pini koraiensis, Lignum corni macrophyllae, old cattle are carried, Fructus Rhodomyrti, Flos Magnoliae Officinalis and Mao Ye Chinese photinia be mixed in proportion, add relative to mixture 5 ~ 8 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.01 ~ 0.02; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;

5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 1 ~ 3: 0.15 ~ 0.3.

Beneficial effect of the present invention: the Chinese medicine preparation that habitual abortion of the present invention uses, combined with westem uses, and easy to use, effectively improve cure rate, have no side effect and untoward reaction, preparation technology is simple.

Detailed description of the invention

The invention provides a kind of Chinese medicine preparation for the treatment of habitual abortion, Chinese medicine preparation comprises following raw medicinal material: Bulbus Allii Macrostemonis, Os Cervi, Semen pini koraiensis, Lignum corni macrophyllae, old cattle are carried, Fructus Rhodomyrti, Flos Magnoliae Officinalis, hair leaf Chinese photinia, common perilla, Radix Inulae, Arisaema balansae Engl. grass, native Fructus Tsaoko, Rhizoma Drynariae, kidney channel grass, Cor Cervi are careless and Radix Morindae Umbellatae.

The pharmacology of various raw medicinal material is as follows:

Bulbus Allii Macrostemonis: [another name] wild Chinese onion, Herba Allii prattii, Bulbus Allii Macrostemonis head, Chinese wild onion.[source] this product is the dry bulb of liliaceous plant Allium macrostemon or Chinese onion.[nature and flavor] are pungent, bitter, temperature.[return through] returns lung, stomach, large intestine channel.[function cures mainly] activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving.For thoracic obstruction pain, phlegm retention cough with asthma is heavy after letting out dysentery.[extracts] " Chinese Pharmacopoeia "

Os Cervi: [source] medical material Ji Yuan: be the skeleton of animal in deer family Cervus nippon Temminck or Cervus elaphus linnaeus.[nature and flavor] sweet in the mouth; Warm in nature.[return through] kidney channel.[function cures mainly] tonify deficiency is won; Bone and muscle strengthening; Except rheumatism; Antidiarrheal dysentery; Promoting tissue regeneration and ulcer healing.Main asthenia weak bone; Rheumatic arthralgia; Dysentery; Scrofula; Sore.[each discussion] 1. " not Lu ": antiabortive, the therapeutic method to keep the adverse QI flowing downwards.2. " a thousand pieces of gold food is in harmony ": main interior-deficiency, continuous wound absolutely, Psoralen, can make wine.3. Tang Materia Medica: main asthenia, can be wine.Main air is empty, Psoralen marrow.[extracts] " China's book on Chinese herbal medicine "

Semen pini koraiensis: [another name] Semen Pini, Semen pini koraiensis, new Luo Songzi.[nature and flavor] are sweet; Slightly warm in nature.[return through] liver; Lung; Large intestine channel.[function cures mainly] moisturizes, and nourishes blood, and dispels the wind.Main dryness of the lung dry cough, stool constipation due to insufficiency, all dizziness due to wind, joint wind, migratory arthralgia.And have moist skin, apply the function of Rong Maofa.[each discussion] 1. " Bencao Jingshu ": Semen pini koraiensis, the fragrant Mei Ganwen of abnormal smells from the patient.Sweet temperature aid yang qi and stimulating the menstrual flow, then joint apoplexy aqueous vapor, and because the dead flesh of dizziness due to wind is from removing.Temperature belongs to sun, and sweet in the mouth is enriched blood, and vim and vigour are sufficient, then the five internal organs are from profit, and bleach not hungry institute origin.2. " explaining abstruseness of the canon of materia medica ": lung benefiting antitussive, benefiting qi and nourishing blood, intestine moistening is quenched the thirst, and warming middle-JIAO searches wind.[extracts] " China's book on Chinese herbal medicine "

Lignum corni macrophyllae: [another name] large-leaved dogwood, Song Yang, cool wood, holly berry, fourth ebon, Cornus controversa, great Ye Cornus controversa, Habenaria aitchisonii.[source] medical material Ji Yuan: be the heartwood of Cornaceae plant (wood comes) wood.[nature and flavor] sweet in the mouth; Salty; Property is put down.[function cures mainly] promoting blood circulation and stopping pain; Nourishing blood and preventing abortion.Main injury and bone fracture; Swelling and pain due to blood stasis; Blood deficiency and yellow complexion; Frequent fetal movement.[extracts] " China's book on Chinese herbal medicine "

Old cattle is carried: [another name] antiabortive spirit.[source] medical material Ji Yuan: be rhizome or the root of irides Iris tenuifolia.[nature and flavor] sweet in the mouth; Light; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing; Diuresis is stopped blooding.Main laryngopharynx swelling and pain; Jaundice due to damp-heat; Dysuria; Spit blood; Epistaxis; Metrorrhagia.[extracts] " China's book on Chinese herbal medicine "

Fructus Rhodomyrti: [another name] Radix Hyperici Monogyni (Herba Hyperici Monogyni), mountain M.-dodecandrum, Duo Lian, Su Yuanzi, Semen Granati, white roller, tremble moo young, harvest son.[source] medical material Ji Yuan: be the myrtaceous fruit of myrtle.[nature and flavor] sweet in the mouth; Puckery; Property is put down.[return through] returns liver; Spleen channel.[function cures mainly] nourishing blood and hemoslasis; Astringing intestine to stop diarrhea controlling nocturnal emission with astringent drugs.Main blood deficiency is weak; Spit blood; Epistaxis; Impairment caused by overstrain hemoptysis; Have blood in stool; Metrorrhagia; Seminal emission; Leukorrhagia; Dysentery; Proctoptosis; Scald; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Flos Magnoliae Officinalis: [another name] spoon flower.[source] is come from " decoction pieces is newly joined ".[source] medical material Ji Yuan: be the alabastrum of Magnoliacea plant Cortex Magnoliae Officinalis or Mount Lushan Cortex Magnoliae Officinalis.[nature and flavor] are pungent; Micro-hardship; Warm in nature.[return through] spleen; Stomach; Lung meridian.[function cures mainly] promoting the circulation of QI to alleviate the stagnation in middle-JIAO; Dissipating depression of QI removing dampness.Main stagnation of liver-QI and stomach-QI; Breast gastral cavity feeling of distension and oppression; Inappetence; Poor appetite; The cards such as cold cough.[extracts] " China's book on Chinese herbal medicine "

Hair leaf Chinese photinia: [another name] Deng is to sight root.[source] medical material Ji Yuan: be root, the fruit of section's vegetable hair leaf Chinese photinia of bowing.[nature and flavor] acrid in the mouth; Bitter; Property is put down.[return through] spleen; Stomach; Large intestine channel.[function cures mainly] clearing away heat-damp and promoting diuresis; With middle spleen invigorating.Main retention of damp-heat in the interior; Vomiting; Dysentery; Impairment caused by overstrain is tired.[each discussion] " Guizhou folk medicine ": except damp and hot, antidiarrheal dysentery.[extracts] " China's book on Chinese herbal medicine "

Common perilla: [source] medical material Ji Yuan: be the stem of labiate common perilla.[nature and flavor] acrid in the mouth; Warm in nature.[function cures mainly] is pleasant to help digestion; Pain relieving; Antiabortive.Staple food is stagnant not to be changed; Abdominal distention; Flu; Frequent fetal movement.[each discussion] be " the southern regions of the Yunnan Province book on Chinese herbal medicine " 1.: invigorating the spleen and replenishing QI.2. " Anhui medical material ": promoting the circulation of QI to alleviate the stagnation in middle-JIAO, expectorant profit lung, antiabortive.3. " Traditional Chinese Medicine in Sichuan will ": expel flatulence and relieve chest stuffiness, reduce phlegm in row, help digestion.Control uncomfortable in chest, dysphagia and regurgitation and cardiac and abdominal pain.[extracts] " China's book on Chinese herbal medicine "

Radix Inulae: [source] this product is the dry root of feverfew Radix Inulae or Radix Inulae.[nature and flavor] are pungent, bitter, temperature.[return through] returns liver, spleen channel.[function cures mainly] invigorating the spleen and regulating the stomach, promoting the flow of QI for relieving the stagnancy, pain relieving is antiabortive.For the breast side of body, abdominal distention, vomiting dysentery, the breast side of body is dampened, and feels a pain in the chest when breathing and has a pain, frequent fetal movement.[extracts] " Chinese Pharmacopoeia "

Arisaema balansae Engl. grass: [another name] hispid sage herb, Guan Gongxu, Arisaema balansae Engl., pass vibrissa, soil are invigorated blood circulation, Radix Rubiae Yunnanensis.[source] medical material Ji Yuan: be labiate Huangpu Salvia japonica Thunb. whole herb with root.[nature and flavor] micro-hardship; Cool in nature.[function cures mainly] wind and heat dispersing; Dampness removing; Arresting bleeding and miscarriage prevention.Main cold, fever; Pneumonia cough with asthma; Laryngopharynx swelling and pain; Hepatitis hypochondriac pain; Diarrhoea; Dysentery; Nephritis; Spit blood; Vaginal bleeding during pregnancy.[extracts] " China's book on Chinese herbal medicine "

Soil Fructus Tsaoko: [another name] Fructus Amomi, native sand.[source] medical material Ji Yuan: be the fruit of zingiberaceous plant Guangxi Fructus Amomi Rotundus.[nature and flavor] acrid in the mouth; Warm in nature.[function cures mainly] regulates the flow of vital energy; Appetizing; Antiabortive.Main abdominal distention; Inappetence; Frequent fetal movement.[extracts] " China's book on Chinese herbal medicine "

Rhizoma Drynariae: the broken benefit of [another name] meat, Fortune's Drynaria Rhizome, monkey Rhizoma Zingiberis Recens, Mao Jiang, drynaria baronii, delevay drynaria, rock connect Rhizoma Zingiberis Recens.[source] this product is the dry rhizome of Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi.[nature and flavor] are bitter, temperature.[return through] returns kidney, Liver Channel.[function cures mainly] the kidney invigorating bone strengthening, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; External treatment alopecia areata, vitiligo.[extracts] " Chinese Pharmacopoeia "

Kidney channel grass: [another name] Yu Feng is colored, eyelashes are blue, native Rhizoma Gastrodiae, Cephalanthera ereota (Thunb.) Blume., Herba Habenariae rhodochellae, Habenaria Ciliolaris Kranzl, Yu Fenglan.[source] medical material Ji Yuan: be the tuber of the beautiful phoenix flower of orchid hair Roripa.[nature and flavor] sweet in the mouth; Micro-hardship; Property is put down.[function cures mainly] the lumbus strengthening and the kidney invigorating; Clearing away heat and promoting diuresis; Removing toxic substances.Main lumbago due to renal deficiency; Seminal emission; Sexual impotence; Leucorrhea; Pyretic stranguria; Venom; Furuncle toxic swelling.[extracts] " China's book on Chinese herbal medicine "

Cor Cervi grass: bloom in [another name] Balanophora dioica R Br ex Royle, Hao Zhihua, soil, red bacterium, milk bacterium.[source] medical material Ji Yuan: be the herb of the thick fringe Balaenoptera borealis Lesson of Balanophoraceae plant.[nature and flavor] are bitter; Puckery; Warm in nature.[function cures mainly] kidney invigorating and YANG supporting; Spleen invigorating is regulated the flow of vital energy; Hemostasis.Main sexual impotence; Dysentery; Stomachache is spitted blood; Menorrhagia; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Radix Morindae Umbellatae: [another name] bar halberd, flour fiber crops, reddish tone root, Herba Morindae Parvifoliae, triangle vine, cat Caulis Sargentodoxae, Caulis Fissistigmatis, Herba Morindae Parvifoliae, bird mud rattan.[source] medical material Ji Yuan: be root or the root bark of dicotyledon medicine Maguireothamnus speciosus Radix Morindae Umbellatae.[nature and flavor] are pungent; Micro-sweet; Temperature.[return through] kidney channel.[function cures mainly] expelling wind and removing dampness; Reinforcing the kidney and arresting hemorrhage.Main wet arthralgia; Lumbago due to renal deficiency; Sexual impotence; Stomachache.[each discussion] 1. " register planted by Guangxi medicine ": root: wind-damp dispelling, detumescence, detoxification.2. " Fujian Chinese herbal medicine ": root bark: wind-damp dispelling, warming the kidney gas.[extracts] " China's book on Chinese herbal medicine "

When the dosage form of described Chinese medicine preparation is tablet, it comprises the following steps:

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: oral solutions prepared by the present invention

Get Bulbus Allii Macrostemonis 260g, Os Cervi 150g, Semen pini koraiensis 210g, Lignum corni macrophyllae 190g, old cattle carry 120g, Fructus Rhodomyrti 280g, Flos Magnoliae Officinalis 210g, hair leaf Chinese photinia 90g, common perilla 370g, Radix Inulae 290g, Arisaema balansae Engl. grass 120g, native Fructus Tsaoko 250g, Rhizoma Drynariae 270g, kidney channel grass 190g, Cor Cervi grass 120g and Radix Morindae Umbellatae 350g.

Its preparation method comprises the following steps:

The first step, Bulbus Allii Macrostemonis, Os Cervi, Semen pini koraiensis, Lignum corni macrophyllae, old cattle are carried, Fructus Rhodomyrti, Flos Magnoliae Officinalis, hair leaf Chinese photinia and common perilla be mixed in proportion, be that the methanol of 80% is as solvent with determining alcohol, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder; The quality of the methanol added is 6 times of first step mixture quality;

Second step, is mixed in proportion surplus stock medical material, is ground into powder; Add the distilled water of the powder quality 6 times obtained relative to second step, decoct 4 hours, filter, obtain the first filtrate; Filtering residue is added the distilled water relative to its quality 3 times, decoct 3 hours, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 volume, add the ethanol that determining alcohol is 95%, make determining alcohol reach 75%, leave standstill 35 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;

3rd step, the powder mixing first step and second step obtained, add the distilled water relative to powder quality 3.6 times amount, the sucrose of 0.23 times, the sodium benzoate of 0.03 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

Embodiment 2: tablet prepared by the present invention

Get Bulbus Allii Macrostemonis 290g, Os Cervi 120g, Semen pini koraiensis 250g, Lignum corni macrophyllae 160g, old cattle carry 150g, Fructus Rhodomyrti 260g, Flos Magnoliae Officinalis 240g, hair leaf Chinese photinia 70g, common perilla 380g, Radix Inulae 260g, Arisaema balansae Engl. grass 150g, native Fructus Tsaoko 230g, Rhizoma Drynariae 280g, kidney channel grass 170g, Cor Cervi grass 150g and Radix Morindae Umbellatae 320g.

Its preparation method comprises the following steps:

The first step, Bulbus Allii Macrostemonis, Os Cervi, Semen pini koraiensis, Lignum corni macrophyllae, old cattle are carried, Fructus Rhodomyrti, Flos Magnoliae Officinalis and Mao Ye Chinese photinia be mixed in proportion, add relative to mixture 7 times amount determining alcohol be 80% alcohol reflux 3 times, each 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 times of water gagings, boils 3 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.29;

3rd step, the mastic mixing that the first step, second step are obtained, 65 DEG C of reduced vacuum dryings, get dry extract powder;

4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.02; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;

5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 3: 0.27.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 20-34g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, fasting 12 hours before experiment, the extract oral liquor prepared by embodiments of the invention 1 is dissolved in water, (concentration is 8.49g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 42.45 crude drugs/kg), matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage oral solutions LD50>42.45 crude drug/kg of the present invention, every day, maximum dosage-feeding was 84.9 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.31g crude drug/day/people, adult body weight in 60KG, average dosage is 0.139g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 27g) oral administration gavage Chinese medicine of the present invention is 611 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 oral solutions of the present invention to three groups of mices (often organize 20) by 12.59,25.37 and 41.53g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: all 142 selected routine cases all derive from the habitual abortion patients of the court, treatment group and each 71 examples of matched group.In treatment group 71 example, age 25-40 year; Abortion times 3-6 time.In matched group 71 example, age 25-41 year; Abortion times 3-5 time.Treatment group and matched group be there was no significant difference (P≤0.01) on age and clinical symptoms, has comparability.

Diagnostic criteria: 1, spontaneous abortion recurs 3 times or more.2, each miscarriage mostly occurs in same gestation month, its clinical process with generally miscarry identical.3, pregnantly repeatly fall repeatly, the bridegroom's or husband's side checks normal.4, chromosome examination, gets rid of caused by inherited genetic factors.5, gynecologial examination uterus is without deformity.

Therapeutic Method:

Matched group: oral vitamin E soft gelatin capsule 100mg, 2 times/d; Chorionic hormone pin 1000u is urged in intramuscular injection, the next day 1 time, change into after 10d every 2d intramuscular injection 1000u to menolipsis 3 months; Inadequate luteal function person, can intramuscular injection Progesterone 20mg, the next day once; Treat 3 months.

Treatment group: on treatment of control group basis, simultaneously oral Chinese medicine embodiment 1 oral solutions of the present invention, each 30ml, every day 3 times; Treat 3 months.

Curative effect judging standard: 1, cure: full-term pregnancy childbirth or gestation were more than 28 weeks; 2, invalid: pregnant less than natural termination in 28 weeks.

Therapeutic outcome: two groups treat 3 months respectively after, statistical result is see table 1.

Table 1 liang group treats Clinical efficacy comparison after 3 months (unit: example) respectively

Group	Number of cases	Cure	Invalid	Total effective rate
					Treatment group	71	68	3	68(95.77％)
Matched group	71	54	17	54(76.06％)

As can be seen from Table 1, treatment group adopts Chinese medicine of the present invention, coordinates western medical treatment habitual abortion, relative to matched group, on therapeutic effect, has significant improvement.

Untoward reaction: in two groups of therapeutic processes, does not all find hepatic and renal function injure or other obvious adverse reaction.

Concrete case: Lee, female, 30 years old, private prosecution was married and is lived together more than 4 years, once conceived 3 times, all in about 6-10 week, occurred the symptoms such as vagina is bled on a small quantity, the soreness of waist, lower abdomen dull pain, miscarriage of failing to respond to any medical treatment, identical in general miscarriage, was diagnosed as habitual abortion.This is that the 4th is conceived, gives oral vitamin E soft gelatin capsule 100mg, 2 times/d; Chorionic hormone pin 1000u is urged in intramuscular injection, the next day 1 time, change into after 10d every 2d intramuscular injection 1000u to menolipsis 3 months; Inadequate luteal function, gives intramuscular injection Progesterone 20mg, the next day once; Oral Chinese medicine embodiment 1 oral solutions of the present invention simultaneously, each 30ml, every day 3 times; After treating March, the every inspection of health all recovers normal, and gestation continues.Natural labor in pregnant 39 weeks 1 girl baby, physically well develops, and cures.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims

1. treat the Chinese medicine preparation of habitual abortion for one kind, it is characterized in that, described Chinese medicine preparation comprises following raw medicinal material: Bulbus Allii Macrostemonis, Os Cervi, Semen pini koraiensis, Lignum corni macrophyllae, old cattle are carried, Fructus Rhodomyrti, Flos Magnoliae Officinalis, hair leaf Chinese photinia, common perilla, Radix Inulae, Arisaema balansae Engl. grass, native Fructus Tsaoko, Rhizoma Drynariae, kidney channel grass, Cor Cervi are careless and Radix Morindae Umbellatae.

2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Bulbus Allii Macrostemonis 25 ~ 35 parts, Os Cervi 10 ~ 20 parts, Semen pini koraiensis 15 ~ 25 parts, Lignum corni macrophyllae 15 ~ 30 parts, old cattle carry 5 ~ 15 parts, Fructus Rhodomyrti 20 ~ 30 parts, Flos Magnoliae Officinalis 15 ~ 25 part, mao leaf Chinese photinia 5 ~ 15 parts, common perilla 30 ~ 40 parts, Radix Inulae 25 ~ 35 parts, Arisaema balansae Engl. grass 10 ~ 20 parts, native Fructus Tsaoko 15 ~ 30 parts, Rhizoma Drynariae 20 ~ 30 parts, kidney channel grass 15 ~ 25 parts, Cor Cervi grass 10 ~ 20 parts and Radix Morindae Umbellatae 25 ~ 35 parts.

3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Bulbus Allii Macrostemonis 25 ~ 30 parts, Os Cervi 10 ~ 15 parts, Semen pini koraiensis 20 ~ 25 parts, Lignum corni macrophyllae 15 ~ 20 parts, old cattle carry 10 ~ 15 parts, Fructus Rhodomyrti 25 ~ 30 parts, Flos Magnoliae Officinalis 20 ~ 25 part, mao leaf Chinese photinia 5 ~ 10 parts, common perilla 35 ~ 40 parts, Radix Inulae 25 ~ 30 parts, Arisaema balansae Engl. grass 10 ~ 15 parts, native Fructus Tsaoko 20 ~ 25 parts, Rhizoma Drynariae 25 ~ 30 parts, kidney channel grass 15 ~ 20 parts, Cor Cervi grass 10 ~ 15 parts and Radix Morindae Umbellatae 30 ~ 35 parts.

4. the Chinese medicine preparation as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Bulbus Allii Macrostemonis 26 parts, Os Cervi 15 parts, Semen pini koraiensis 21 parts, Lignum corni macrophyllae 19 parts, old cattle carry 12 parts, Fructus Rhodomyrti 28 parts, Flos Magnoliae Officinalis 21 part, mao leaf Chinese photinia 9 parts, common perilla 37 parts, Radix Inulae 29 parts, Arisaema balansae Engl. grass 12 parts, native Fructus Tsaoko 25 parts, Rhizoma Drynariae 27 parts, kidney channel grass 19 parts, Cor Cervi grass 12 parts and Radix Morindae Umbellatae 35 parts.

5. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is oral solutions, and its preparation method comprises the following steps:

6. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps:

7. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is oral solutions, and its preparation method comprises the following steps:

8. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps: