CN103520665A - Chinese medicament for miscarriage prevention at early pregnant stage of pregnant woman and preparation method thereof - Google Patents

Abstract

The invention discloses a Chinese medicament for miscarriage prevention at the early pregnant stage of a pregnant woman and a preparation method thereof. The Chinese medicament comprises Chinese medicinal components such as angelica, radix paeoniae alba, tuckahoe, rhizoma ligustici wallichii, rhizoma atractylodis alba, pilose asiabell root, astragalus root, egg shells and ginger. The Chinese medicament can achieve a good curative effect through reasonable compatibility of medicines and different roles including sovereign, minister, assistant and courier of the ingredients of the medicament, the curative is significant, and the medicament is especially suitable for habitual abortion patients; the preparation method is simple, convenient and feasible and is low in cost.

Description

Chinese medicine that a kind of anemia of pregnant woman's gestation initial stage is antiabortive and preparation method thereof

Technical field

The invention belongs to technical field of Chinese medicines, specifically a kind of anemia of pregnant woman's gestation antiabortive Chinese medicine of initial stage and preparation method thereof.

Background technology

Miscarriage refers to that gestation stopped before 28 weeks, and fetal weight claimed early abortion before the following person's miscarriage of 1000g occurs in pregnant 12 weeks, general many and inherited genetic factors, and female endocrine disturbance and immunology factor etc. are relevant; Occur in 12-28 week for late abortion, how relevant with uterine malformation, cervix uteri dysplasia, blood group incompatibility and the mother factors such as disease that take a disease.Situation when medical according to patient, can be divided into threatened abortion, inevitable abortion, incomplete abortion, artificial abortion, missed abortion, habitual abortion and septic abortion.

Habitual abortion refers to and recurs above person 3 times, its clinical symptoms is with vaginal hemorrhage, paroxysmal abdominal pain is main, habitual abortion, because the cause of disease is unclear, without effective sorting technique, clinician many threatened abortion stage blindly give progestogen or chorionic-gonadotropin hormone gives so-called antiabortive treatment, to the pair of anemia of pregnant woman and fetus, as large, effect is undesirable.

Summary of the invention

The problem to be solved in the present invention is for above problem, and antiabortive Chinese medicine of a kind of anemia of pregnant woman gestation initial stage and preparation method thereof is provided, and this Chinese medicine was taken at the gestation initial stage, have antiabortive, prevent miscarriage, anti-curative effect of falling, can effectively prevent anemia of pregnant woman's miscarriage.

For addressing the above problem, the technical solution adopted in the present invention is:

Anemia of pregnant woman's gestation antiabortive Chinese medicine of initial stage, this Chinese medicine is prepared from by following weight parts raw material: 25 parts of Radix Angelicae Sinensis, 15 parts of the Radix Paeoniae Albas, 15 parts, Poria, 25 parts of Rhizoma Chuanxiongs, 15 parts of Rhizoma Alismatis, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts of Placenta Hominiss, 25 parts of Radix Codonopsis, 25 parts of the Radixs Astragali, 30 parts of Radix Ophiopogonis, 10 parts, Radix Glycyrrhizae, 35 parts of Folium Perillaes, 35 parts of Semen Cuscutae, 25 parts of Radix Inulaes, 25 parts of Radix Boehmeriaes, 12 parts of Herba Epimedii, 25 parts, Fructus Jujubae, 5 parts of Fructus Lycii, 8 parts of Setaria palmifolia, 5 parts of Pericarppium arachidis hypogaeaes, 10 parts of Radix Panacis Quinquefoliis; 5 parts of Ovum crusta Gallus domesticuss; 15 parts, Rhizoma Zingiberis Recens.

A preparation method for the Chinese medicine that the gestation initial stage is antiabortive, comprises the following steps:

1) rear 10 times of decoctings of crude drug weight that add up of Radix Inulae, Fructus Jujubae, Fructus Lycii, Radix Angelicae Sinensis, Radix Panacis Quinquefolii, the Radix Paeoniae Alba, Semen Cuscutae, Radix Ophiopogonis, Rhizoma Chuanxiong, Poria, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Herba Epimedii, Radix Codonopsis, Radix Astragali cleaning of, getting above-mentioned weight portion boil, after ebuillition of heated, decoct 30 minutes, leach medicine juice A, add 5 times of decoctings of total raw material medicine weight to boil again, after ebuillition of heated, decoct 20 minutes, leach to obtain medicine juice B, add again 5 times of decoctings of total raw material medicine weight to boil, after ebuillition of heated, decoct 10 minutes, leach to obtain medicine juice C:

2), the Ovum crusta Gallus domesticus of above-mentioned mass parts is burnt to carbon shape, grind to obtain fine powder D, the Pericarppium arachidis hypogaeae of above-mentioned mass parts is burnt to carbon shape, grind to obtain fine powder E;

3), the Rhizoma Zingiberis Recens of above-mentioned weight portion is mashed, obtain Sucus Zingberis and Rhizoma Zingiberis Recens dregs;

4), merge medicine juice A, medicine juice B, medicine juice C, in amalgamation liquid, add fine powder D, fine powder E, Sucus Zingberis and Rhizoma Zingiberis Recens dregs, be then heated to boiling, obtain medicine.

Radix Angelicae Sinensis: enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation.

The Radix Paeoniae Alba: the easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, QI invigorating, that paeoniflorin in the Radix Paeoniae Alba has is antibiotic, analgesic, antiinflammatory, increase coronary flow, improve the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjusting blood glucose, and Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.

Poria: promoting diuresis to eliminate damp pathogen, invigorating the spleen for dissipating phlegm, mind tranquilizing and the heart calming, relieves internal heat anticancer, and the property of medicine is gentle, and dampness removing and do not hinder healthy energy is antiabortive first-selection.

Rhizoma Chuanxiong: promoting flow of QI and blood, tranquillizing and allaying excitement, anti-inflammation, vigorate qi and replenish the blood.

The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach, dampness diuretic, reduces phlegm, and hidroschesis is antiabortive, increases appetite; The vitamin A that the Rhizoma Atractylodis Macrocephalae contains volatile oil, atractylol, Rhizoma Atractylodis ketone and health had to benefiting action.

Radix Codonopsis: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst etc.

The Radix Astragali: benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, inducing diuresis to remove edema.

Radix Ophiopogonis: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.

Radix Glycyrrhizae: treating disorders in five ZANG-organs six internal organs cold and heat pathogen, hard muscles and bones, longue meat, times strength, removing toxic substances, clothes are made light of one's life by commiting suicide and are prolonged life for a long time.Raw by pathogenic fire purging heat, the ripe use exterior cold of fall apart, goes pharyngalgia, except pathogenic heat, delays healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening.

Semen Cuscutae: gas and property are slow, can float and can sink, and have the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, the solid tire of spleen invigorating.

Radix Inulae: invigorating the spleen and regulating the stomach, promoting the flow of QI for relieving the stagnancy, pain relieving is antiabortive.

Herba Epimedii: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.

Fructus Jujubae: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind; For insufficiency of the spleen lack of appetite, weak loose stool.

Fructus Lycii: nourishing the liver, nourishing kidney, lung moistening, benefiting qi and nourishing blood.

Pericarppium arachidis hypogaeae: astringing lung-QI and relieving cough.

Radix Panacis Quinquefolii: boosting qi and nourishing yin, clearing away heat and promoting production of body fluid, loses for the deficiency of vital energy is cloudy, interior-heat, Radix Panacis Quinquefolii has the effect of resisting fatigue, antioxidation, anti-stress, anticoagulant, reduction blood coagulation.

Rhizoma Zingiberis Recens: and middle preventing or arresting vomiting, relieving the exterior syndrome by diaphoresis, warming blood vessels.

Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Herba Epimedii, Fructus Jujubae, Fructus Lycii, Semen Cuscutae, Radix Codonopsis, the Radix Astragali and Radix Panacis Quinquefolii have invigorating the spleen and replenishing QI, the invigorate blood circulation effect of relieving thirst and restlessness, Radix Ophiopogonis, Folium Perillae have lung moistening and clear away heart-fire, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, Radix Inulae hemostasis and pain-relieving, Rhizoma Zingiberis Recens warming blood vessels, Pericarppium arachidis hypogaeae, Ovum crusta Gallus domesticus are guiding drug, do not use Pericarppium arachidis hypogaeae, Ovum crusta Gallus domesticus to take effect slower, but also can play a role, after use Pericarppium arachidis hypogaeae, Ovum crusta Gallus domesticus, drug effect is remarkable.

This medicine is by rational compatibility, and monarch, makes medicine reach good curative effect, evident in efficacy, is particularly useful for the patient of habitual abortion.

The decoct of gained medicine is divided into three parts, and the morning, noon and afternoon service once, and period in a medicine is avoided pungent irritable food, prohibit seafood, within 5 days, are a course for the treatment of, generally take 5 courses for the treatment of, and between adjacent two courses for the treatment of, drug withdrawal is three days.

The specific embodiment

Embodiment 1, an anemia of pregnant woman gestation antiabortive Chinese medicine of initial stage, gets the crude drug of following weight portion: 25 parts of Radix Inulaes, 25 parts, Fructus Jujubae, 5 parts of Fructus Lycii, 25 parts of Radix Angelicae Sinensis, 10 parts of Radix Panacis Quinquefoliis, 15 parts of the Radix Paeoniae Albas, 35 parts of Semen Cuscutae, 15 parts, Poria, 15 parts, Rhizoma Zingiberis Recens, 30 parts of Radix Ophiopogonis, 25 parts of Rhizoma Chuanxiongs, 10 parts, Radix Glycyrrhizae, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts of Herba Epimedii, 25 parts of Radix Codonopsis, 25 parts of the Radixs Astragali, 5 parts of Pericarppium arachidis hypogaeaes, 5 parts of Ovum crusta Gallus domesticuss.

Wherein, the unit of weight portion is gram that every part is every gram.

The preparation method of above-mentioned Chinese medicine, comprises the following steps:

1), get and after above-mentioned weight portion Radix Inulae, Fructus Jujubae, Fructus Lycii, Radix Angelicae Sinensis, Radix Panacis Quinquefolii, the Radix Paeoniae Alba, Semen Cuscutae, Radix Ophiopogonis, Rhizoma Chuanxiong, Poria, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Herba Epimedii, Radix Codonopsis, the Radix Astragali clean, add up 10 times of decoctings of crude drug weight and boil, after ebuillition of heated, decoct 30 minutes, leach medicine juice A, add 5 times of decoctings of total raw material medicine weight to boil again, after ebuillition of heated, decoct 20 minutes, leach to obtain medicine juice B, add again 5 times of decoctings of total raw material medicine weight to boil, after ebuillition of heated, decoct 10 minutes, leach to obtain medicine juice C:

2), the Ovum crusta Gallus domesticus of above-mentioned quality is burnt to carbon shape, grind to obtain fine powder D, the Pericarppium arachidis hypogaeae of above-mentioned mass parts is burnt to carbon shape, grind to obtain fine powder E;

3), the Rhizoma Zingiberis Recens of above-mentioned weight portion is mashed, obtain Sucus Zingberis and Rhizoma Zingiberis Recens dregs;

4), merge medicine juice A, medicine juice B, medicine juice C, in amalgamation liquid, add fine powder D, fine powder E, Sucus Zingberis and Rhizoma Zingiberis Recens dregs, be then heated to boiling, obtain medicine.

We select 90 examples to have the patient of miscarriage disease, wherein, the experience that the rarest mistake of they each patient is once miscarried, also there is the repeatedly experience of miscarriage, in 90 routine patients, there are 56 examples to select medicine of the present invention (treatment group), there are 34 routine patients to select hospitalize (matched group), prevent miscarriage, antiabortive treatment, also have 10 routine patients to select the expectant treatment (blank group) of not taking medicine, not being in hospital.

Criterion of therapeutical effect:

Cure: the every sign of fetus is normal, enters expected date of confinement smoothly, and anemia of pregnant woman's health has no adverse reaction.

Effective: the every sign of fetus is normal, the production time shifts to an earlier date 3-4 week than expected date of confinement, and anemia of pregnant woman's health has no adverse reaction.

Effective: the every sign of fetus is normal, the time was over 28 weeks.

Invalid: fetus less than is just born for 20 weeks.

Table one

Group name/index	Number of cases	Cure n (%)	Effective n (%)	Effective n (%)	Invalid n (%)
						Treatment group	56	42(75.0)	50(89.3)	55(98.2)	1(1.2)
Matched group	34	14(41.2)	20(58.8)	24(70.6)	10(29.4)
						Blank group	10	——	——	——	10(100)

By the data in table one, can find out, utilize patient's cure rate for the treatment of by Chinese herbs of the present invention high, and effective percentage is up to 98.2%, not only can guarantee that fetus produced after 28 weeks, but also the painful ，Gei patient family that has alleviated patient has brought happiness.

Model case:

Grandson, 29 years old, conceived 45 days, respectively in April, 2010, in February, 2011 secondary abortion, be gestation 2 months, without obvious inducement, pregnancy in August, 2012, doctor advised Chinese medicine is antiabortive, gestation is taken Chinese medicine of the present invention in the time of 2 months, take 4 courses for the treatment of, until enter expected date of confinement, without difference, react, next healthy girl baby of natural labor in this year.

Lee 32 years old, pregnant 2 wheat harvesting periods, once in June, 2007, in August, 2009, in October, 2011 miscarriage, pregnancy in May, 2,012 two months, frequent stomachache, time during pain only, tenesmus as wish product, vagina is hemorrhage on a small quantity, takes 3 of this medicines transference cure course for the treatment of, gives birth to smoothly a healthy boy baby end of the year 2012.

Wang, 28 years old, gestation 40 days, once, in August, 2007, in November, 2009, in January, 2012 miscarriage, without obvious inducement, doctor advised Chinese medicine was antiabortive, took Chinese medicine of the present invention, took after 3 courses for the treatment of, and drug withdrawal, in next healthy boy baby of natural labor in May, 2013.

Claims (2)

1. anemia of pregnant woman's gestation antiabortive Chinese medicine of initial stage, is characterized in that: this Chinese medicine is prepared from by following weight parts raw material: 25 parts of Radix Inulaes, 25 parts, Fructus Jujubae, 5 parts of Fructus Lycii, 25 parts of Radix Angelicae Sinensis, 10 parts of Radix Panacis Quinquefoliis, 15 parts of the Radix Paeoniae Albas, 35 parts of Semen Cuscutae, 15 parts, Poria, 15 parts, Rhizoma Zingiberis Recens, 30 parts of Radix Ophiopogonis, 25 parts of Rhizoma Chuanxiongs, 10 parts, Radix Glycyrrhizae, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts of Herba Epimedii, 25 parts of Radix Codonopsis, 25 parts of the Radixs Astragali, 5 parts of Pericarppium arachidis hypogaeaes, 5 parts of Ovum crusta Gallus domesticuss.

2. the preparation method of antiabortive Chinese medicine of a kind of anemia of pregnant woman gestation initial stage as claimed in claim 1, is characterized in that: comprise the following steps:

1) rear 10 times of decoctings of crude drug weight that add up of Radix Inulae, Fructus Jujubae, Fructus Lycii, Radix Angelicae Sinensis, Radix Panacis Quinquefolii, the Radix Paeoniae Alba, Semen Cuscutae, Radix Ophiopogonis, Rhizoma Chuanxiong, Poria, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Herba Epimedii, Radix Codonopsis, Radix Astragali cleaning of, getting above-mentioned weight portion boil, after ebuillition of heated, decoct 30 minutes, leach medicine juice A, add 5 times of decoctings of total raw material medicine weight to boil again, after ebuillition of heated, decoct 20 minutes, leach to obtain medicine juice B, add again 5 times of decoctings of total raw material medicine weight to boil, after ebuillition of heated, decoct 10 minutes, leach to obtain medicine juice C:

2), the Ovum crusta Gallus domesticus of above-mentioned mass parts is burnt to carbon shape, grind to obtain fine powder D, the Pericarppium arachidis hypogaeae of above-mentioned mass parts is burnt to carbon shape, grind to obtain fine powder E;

3), the Rhizoma Zingiberis Recens of above-mentioned weight portion is mashed, obtain Sucus Zingberis and Rhizoma Zingiberis Recens dregs;

4), merge medicine juice A, medicine juice B, medicine juice C, in amalgamation liquid, add fine powder D, fine powder E, Sucus Zingberis and Rhizoma Zingiberis Recens dregs, be then heated to boiling, obtain medicine.