CN101244195B - Medicament for treating aypnia - Google Patents
Medicament for treating aypnia Download PDFInfo
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- CN101244195B CN101244195B CN2008100814786A CN200810081478A CN101244195B CN 101244195 B CN101244195 B CN 101244195B CN 2008100814786 A CN2008100814786 A CN 2008100814786A CN 200810081478 A CN200810081478 A CN 200810081478A CN 101244195 B CN101244195 B CN 101244195B
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Abstract
The invention discloses a drug for treating insomnia, belonging to the Chinese medicine field, which is prepared with rehmannia root, common anemarrhena rhizome, danshen root, root poria, lily bulb, albizzia flower, seed of oriental arborvitae, milkwort root and fried jujube seed in a given weight ratio, the drug can be prepared into any common oral dosage form. The drug has the advantages of functions of nourishing yin and stomach and tranquilizing spirit and eliminating melancholy, no side effect, 86.3% cure rate in one course, and 98.6% cure rate in two courses.
Description
Technical field
The present invention relates to the field of Chinese medicines, especially a kind of medicine of Cure for insomnia.
Background technology
Sleep is one of important objective index of health, and insomnia is modal sleep disorder, it is by lack of preservation of spirit or uneasy and cause, mainly show as the deficiency of the length of one's sleep, the degree of depth, and can not allaying tiredness, regain one's strength and energy, this disease has seriously hindered human orthobiosis, and can increase the weight of or bring out diseases such as cardiopalmus, the thoracic obstruction, dizzy, headache, apoplexy, and intractable insomnia more brings secular misery to the patient.At present, the universal method that the patient is alleviated this disease is to take the medicine with the effect of necessarily sleeping peacefully, but can not treat at all, can form the dependence to sleeping pill, and this class medicine mostly has certain side effect, takes for a long time also to cause the disease even more serious than insomnia.
Summary of the invention
The medicine that the purpose of this invention is to provide a kind of Cure for insomnia, this medicine have tonifying-Yin and nourishing-stomach, the effect of the resolving depression of calming the nerves.
Medicine of the present invention selects the Radix Rehmanniae, the Rhizoma Anemarrhenae, Radix Salviae Miltiorrhizae, Poria cum Radix Pini, Bulbus Lilii, Flos Albiziae, Semen Platycladi, Radix Polygalae, Semen Ziziphi Spinosae (parched) to make up, and makes the effect of each medicine produce synergism these medicament composing prescriptions, thus effective Cure for insomnia disease.Wherein, the Radix Rehmanniae: nature and flavor sweetness and bitterness is cold, and GUIXIN liver lung meridian helps heart and gallbladder gas, peace soul to decide soul.Fresh or exsiccant tuber for yellow Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch.Excavate autumn, and using fresh herb or dry sliced giving birth to are used." Japan hanako materia medica ": Radix Rehmanniae, help heart and gallbladder gas, the peace soul is decided soul, controls palpitation with fear, and the bad cardiopulmonary of labor decrease, haematemesis epistaxis, married woman's metrorrhagia blood fortune helps muscles and bones, long will.
The Rhizoma Anemarrhenae: the property bitter but sweet flavor is cold, returns lung stomach kidney channel, clearing away heat-fire, nourshing Yin and drynsessmoistening prescription.Dry rhizome for liliaceous plant Rhizoma Anemarrhenae Anemarrhena asphodeloides Bge..Two seasons of spring and autumn excavate.Remove fibrous root and silt, dry.
Radix Salviae Miltiorrhizae: the nature and flavor hardship is slightly cold, the GUIXIN Liver Channel, and stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Dry root and rhizome for labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..
Poria cum Radix Pini: the property slightly sweet flavor is flat, the GUIXIN spleen channel, mind calming, calm the nerves, diuretic.Entertain Radix Pini massonianae or thin Masson Pine heart person's part for (Poria) in the middle of the poria cocos sclerotium.Be cut into thin square more, solid." property of medicine opinion ": main infantile convulsion, tranquilizing the mind is mended tired.
Bulbus Lilii: nature and flavor are sweet to be slightly cold, GUIXIN lung meridian, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.This product is the underground bulb of Liliaceae herbaceos perennial Bulbus Lilii Lilium brownii var.viridulum Baker." Japan hanako materia medica ": feel at ease, decide gallbladder, beneficial will is supported five and is hidden, and controls insane heresy, weep, and mad crying, diseases due to noxious agents produced by various parasites gas is killed in palpitation with fear, and carbuncle in the hypochondriac region acute mastitis carbuncle on the back and all skin ulcers are swollen, and the mad fortune of the bleeding from anus of managing property.
Flos Albiziae: nature and flavor are sweet flat, GUIXIN Liver Channel, resolving stagnation for tranquilization.Be leguminous plant Herba Albiziae Albizia julibrissin
Durazz. dry inflorescence.Summer, the flowers are in blossom selects fine day when putting and gathers, and in time dries.
Semen Platycladi: nature and flavor are sweet flat, GUIXIN kidney large intestine channel, tranquilizing by nourishing the heart, hidroschesis, intestine moistening.Kernel for Cupressaceae plant Cacumen Platycladi Biotaorientalis (L.) End1.." medicine justice " carries " the saturating heart of Semen Platycladi fragrance, body profit taste blood.”
Radix Polygalae: nature and flavor temperature toil is puckery, calms the nerves, eliminates the phlegm, subsides a swelling.Herbaceos perennial Radix Polygalae Polygalatenuifolia, all produce on slope, north and south, the Qinling Mountains, is born in the patana or the roadside of height above sea level 400-1000 rice.
Semen Ziziphi Spinosae (parched): nature and flavor are flat sweet, nourish heart, calm the nerves, arresting sweating.Seed SemenZiziphi Spinosae for Rhamnaceae plant Ziziphi Spinosae." not Lu ": main vexatious insomnia, umbilicus is pain up and down, and blood changes chronic diarrhea, the sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, hard muscles and bones is helped cloudy gas, makes us fertile strong.
By said medicine combination, interact, complementarity and mutual benefit has tonifying-Yin and nourishing-stomach, an effect of the resolving depression of calming the nerves.
In order to reach better therapeutic, medicine of the present invention also makes up with Rhizoma Dioscoreae, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Radix Polygoni Multiflori Teng, wherein Rhizoma Dioscoreae: nature and flavor are sweet flat, return lung spleen kidney channel, spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Dry tuber for Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita.Cylindrical, meat, plumpness.Compendium of Material Medica is summarized five big functions " kidney tonifying gas, strengthening the spleen and stomach, stopping leak dysentery, the saliva that reduces phlegm, profit skin ".
The Rhizoma Atractylodis Macrocephalae: nature and flavor sweetness and bitterness temperature, return the taste warp, replenishing QI to invigorate the spleen, strengthening superficial resistance to stop perspiration.Dry rhizome for feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz.." medicine origin " record: " the dry and middle QI invigorating of dehumidifying benefit, warming middle-JIAO removes the taste being attacked by dampness, removes gastric heat, and strong taste advance diet, quench the thirst, and are antiabortive.”
Pericarpium Citri Reticulatae: nature and flavor temperature toil, return the lung spleen channel, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Dry mature skin for rutaceae orange Citrus reticulata Blanco and variety thereof.Pluck mature fruit, strip peel, dry or cold drying.
Radix Glycyrrhizae: nature and flavor are sweet flat, invigorating the heart and spleen, nourishing the lung to arrest cough, eliminating fire and detoxication, slow convulsion pain relieving.Be pulse family herbaceos perennial Radix Glycyrrhizae Radix Glycyrrhizae." Japan hanako materia medica " record: " the peace soul is decided soul.Mend five kinds of strain and seven kinds of impairment, all are deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle is separated cold and hot.”
Caulis Polygoni Multiflori: nature and flavor are sweet flat, GUIXIN Liver Channel, nourishing blood to tranquillize the mind, dispelling wind and removing obstruction in the collateral.Dry rattan for polygonum multiflorum thunb Polygonum multiflorum Thunb..Autumn, two seasons of winter tap, and remove residual leaf, tie into handle, drying.
Drug dose of the present invention is groped to sum up to draw through the inventor in a large number, and each crude drug consumption all has curative effect preferably in the scope of following portions by weight: Radix Rehmanniae 3-6 part, Rhizoma Anemarrhenae 3-6 part, Radix Salviae Miltiorrhizae 8-12 part, Poria cum Radix Pini 8-12 part, Bulbus Lilii 4-7 part, Flos Albiziae 13-18 part, Semen Platycladi 8-12 part, Radix Polygalae 4-7 part, Semen Ziziphi Spinosae (parched) 8-12 part.
Its optimum ratio is 4 parts in the Radix Rehmanniae, 4 parts of the Rhizoma Anemarrhenaes, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Poria cum Radix Pinis, 5 parts of Bulbus Liliies, 15 parts of Flos Albiziaes, 9 parts of Semen Platycladi, 5 parts of Radix Polygalaes, 10 parts of Semen Ziziphi Spinosae (parched)s.
Each crude drug consumption of medicine of the present invention can also be Rhizoma Dioscoreae 4-7 part, Rhizoma Atractylodis Macrocephalae 6-9 part, Pericarpium Citri Reticulatae 4-7 part, Radix Glycyrrhizae 0.5-2 part, Caulis Polygoni Multiflori 8-12 part.
Its optimum ratio is 4 parts in the Radix Rehmanniae, 4 parts of the Rhizoma Anemarrhenaes, 5 parts of Rhizoma Dioscoreaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Pericarpium Citri Reticulataes, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Poria cum Radix Pinis, 5 parts of Bulbus Liliies, 15 parts of Flos Albiziaes, 9 parts of Semen Platycladi, 5 parts of Radix Polygalaes, 10 parts of Semen Ziziphi Spinosae (parched)s, 1 part in Radix Glycyrrhizae, 10 parts of Caulis Polygoni Multiflori.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, capsule, oral liquid etc.For example these crude drug pulverize mix homogeneously can be made the powder electuary; Can use decocting, get filtrate after filtration, add antiseptic and make oral liquid; Also can directly take decoction in case of necessity.
Effects such as medicine of the present invention has tonifying-Yin and nourishing-stomach, the resolving depression of calming the nerves, short treating period, evident in efficacy, without any side effects, according to clinical 200 routine patients being observed statistics, taking course cure rate of prescription of the present invention is that 86.3%, two course cure rate is 98.6%.
The specific embodiment
Embodiment one, 3 parts in the Radix Rehmanniae, 3 parts of the Rhizoma Anemarrhenaes, 8 parts of Radix Salviae Miltiorrhizaes, 8 parts of Poria cum Radix Pinis, 4 parts of Bulbus Liliies, 13 parts of Flos Albiziaes, 8 parts of Semen Platycladi, 4 parts of Radix Polygalaes, 8 parts of Semen Ziziphi Spinosaes.
Embodiment two, 4 parts in the Radix Rehmanniae, 4 parts of the Rhizoma Anemarrhenaes, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Poria cum Radix Pinis, 5 parts of Bulbus Liliies, 15 parts of Flos Albiziaes, 9 parts of Semen Platycladi, 5 parts of Radix Polygalaes, 10 parts of Semen Ziziphi Spinosaes.
Embodiment three, 6 parts in the Radix Rehmanniae, 6 parts of the Rhizoma Anemarrhenaes, 12 parts of Radix Salviae Miltiorrhizaes, 12 parts of Poria cum Radix Pinis, 7 parts of Bulbus Liliies, 18 parts of Flos Albiziaes, 12 parts of Semen Platycladi, 7 parts of Radix Polygalaes, 12 parts of Semen Ziziphi Spinosaes.
Embodiment four, 3 parts in the Radix Rehmanniae, 3 parts of the Rhizoma Anemarrhenaes, 4 parts of Rhizoma Dioscoreaes, 6 parts of the Rhizoma Atractylodis Macrocephalaes, 4 parts of Pericarpium Citri Reticulataes, 8 parts of Radix Salviae Miltiorrhizaes, 8 parts of Poria cum Radix Pinis, 4 parts of Bulbus Liliies, 13 parts of Flos Albiziaes, 8 parts of Semen Platycladi, 4 parts of Radix Polygalaes, 8 parts of Semen Ziziphi Spinosaes, 0.5 part in Radix Glycyrrhizae, 8 parts of Caulis Polygoni Multiflori.
Embodiment five, 4 parts in the Radix Rehmanniae, 4 parts of the Rhizoma Anemarrhenaes, 5 parts of Rhizoma Dioscoreaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Pericarpium Citri Reticulataes, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Poria cum Radix Pinis, 5 parts of Bulbus Liliies, 15 parts of Flos Albiziaes, 9 parts of Semen Platycladi, 5 parts of Radix Polygalaes, 10 parts of Semen Ziziphi Spinosaes, 1 part in Radix Glycyrrhizae, 10 parts of Caulis Polygoni Multiflori.
Embodiment six, 6 parts in the Radix Rehmanniae, 6 parts of the Rhizoma Anemarrhenaes, 7 parts of Rhizoma Dioscoreaes, 9 parts of the Rhizoma Atractylodis Macrocephalaes, 7 parts of Pericarpium Citri Reticulataes, 12 parts of Radix Salviae Miltiorrhizaes, 12 parts of Poria cum Radix Pinis, 7 parts of Bulbus Liliies, 18 parts of Flos Albiziaes, 12 parts of Semen Platycladi, 7 parts of Radix Polygalaes, 12 parts of Semen Ziziphi Spinosaes, 2 parts in Radix Glycyrrhizae, 12 parts of Caulis Polygoni Multiflori.
Be the clinical observation of medicine of the present invention below:
One, physical data
Accept out-patient's totally 200 examples for medical treatment, male's 90 examples wherein, women's 60 examples, men and women's ratio 1.5: 1.Age 20-30 year 20 examples, 31-40 year 43 examples, 41-50 year 75 examples, 62 examples more than 51 years old.
Two, diagnostic criteria
1, tcm diagnosis standard: have difficulty in going to sleep or dreaming often and waking easily, feelings will is not relaxed, and is depressed, being irritable and getting angry easily very then, and feeling of fullness and disecomfort in the chest and hypochondrium or chest and diaphragm are not smooth, and bitter taste is dizzy, the vexed heating installation of gastral cavity, stringy pulse dialectically is the stagnation of liver-QI card of overtaxing one's nerves.
2, Western medicine diagnose standard
The insomnia diagnoses with reference to Chinese mental sickness classification schemes and diagnostic criteria (CCMD-2-R), be unique symptom almost with sleep disorder, other symptoms all are secondary to insomnia, comprise have difficulty in going to sleep, insomnia-middle, easily wake up, dreaminess, early awakening, the back of waking up be difficult for sleeping again, the back sense of waking up is uncomfortable, tired or daytime is sleepy; Above-mentioned sleep disorder takes place weekly 3 times at least, and more than 1 month; Insomnia causes significant worries, or the ergasia decrease in efficiency, or hinders social function; It or not the part of any physical disease or mental disorder symptom.
3, Therapeutic Method
According to drug ratios of the present invention, take by weighing raw material (dosage), obtain medicinal liquid according to the method for boiling medicine usually, every day, potion serviced once sooner or later, and taking one month is a course of treatment.
4, efficacy assessment standard
Cure: (1), sleeping in 15 minutes; (2), wake up in sleeping sleeping once more in 15 minutes; (3), 24 hour length of one's sleep was above 6 hours.
Do not heal: (1), in 15 minutes, can't fall asleep; (2), be lower than 6 hours 24 hour length of one's sleep.
5, therapeutic outcome statistics
Claims (4)
1. the medicine of a Cure for insomnia is characterized in that it is to be made by following bulk drugs: Radix Rehmanniae 3-6 part, Rhizoma Anemarrhenae 3-6 part, Radix Salviae Miltiorrhizae 8-12 part, Poria cum Radix Pini 8-12 part, Bulbus Lilii 4-7 part, Flos Albiziae 13-18 part, Semen Platycladi 8-12 part, Radix Polygalae 4-7 part, Semen Ziziphi Spinosae (parched) 8-12 part.
2. medicine according to claim 1 is characterized in that wherein each crude drug consumption is 4 parts in the Radix Rehmanniae, 4 parts of the Rhizoma Anemarrhenaes, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Poria cum Radix Pinis, 5 parts of Bulbus Liliies, 15 parts of Flos Albiziaes, 9 parts of Semen Platycladi, 5 parts of Radix Polygalaes, 10 parts of Semen Ziziphi Spinosae (parched)s.
3. the medicine of a Cure for insomnia is characterized in that it is to be made by following bulk drugs: Radix Rehmanniae 3-6 part, Rhizoma Anemarrhenae 3-6 part, Radix Salviae Miltiorrhizae 8-12 part, Poria cum Radix Pini 8-12 part, Bulbus Lilii 4-7 part, Flos Albiziae 13-18 part, Semen Platycladi 8-12 part, Radix Polygalae 4-7 part, Semen Ziziphi Spinosae (parched) 8-12 part, Rhizoma Dioscoreae 4-7 part, Rhizoma Atractylodis Macrocephalae 6-9 part, Pericarpium Citri Reticulatae 4-7 part, Radix Glycyrrhizae 0.5-2 part, Caulis Polygoni Multiflori 8-12 part.
4. medicine according to claim 3 is characterized in that wherein each crude drug consumption is 4 parts in the Radix Rehmanniae, 4 parts of the Rhizoma Anemarrhenaes, 5 parts of Rhizoma Dioscoreaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Pericarpium Citri Reticulataes, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Poria cum Radix Pinis, 5 parts of Bulbus Liliies, 15 parts of Flos Albiziaes, 9 parts of Semen Platycladi, 5 parts of Radix Polygalaes, 10 parts of Semen Ziziphi Spinosae (parched)s, 1 part in Radix Glycyrrhizae, 10 parts of Caulis Polygoni Multiflori.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100814786A CN101244195B (en) | 2008-02-17 | 2008-02-17 | Medicament for treating aypnia |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100814786A CN101244195B (en) | 2008-02-17 | 2008-02-17 | Medicament for treating aypnia |
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| CN101244195A CN101244195A (en) | 2008-08-20 |
| CN101244195B true CN101244195B (en) | 2010-12-22 |
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| CN2008100814786A Expired - Fee Related CN101244195B (en) | 2008-02-17 | 2008-02-17 | Medicament for treating aypnia |
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293301B (en) * | 2011-08-26 | 2012-10-17 | 天津尖峰弗兰德医药科技发展有限公司 | Health care tea with hypnosis effect and preparation method |
| CN103181434B (en) * | 2012-06-06 | 2014-09-10 | 严丰丽 | Comfortable health-care tea and preparation method thereof |
| CN104225194A (en) * | 2013-06-24 | 2014-12-24 | 山东明仁福瑞达制药股份有限公司 | Traditional Chinese medicine for treating insomnia |
| CN104001067A (en) * | 2014-06-10 | 2014-08-27 | 滕秀君 | Traditional Chinese medicine composition for curing intractable insomnia |
| CN104397282A (en) * | 2014-11-27 | 2015-03-11 | 青岛申达高新技术开发有限公司 | Tranquilization and brain tonifying eleutherococcus senticosus healthare tea and preparation method thereof |
| CN104352998A (en) * | 2014-12-08 | 2015-02-18 | 杨其义 | Traditional Chinese medicine composition for treating severe insomnia |
| CN105412292A (en) * | 2015-12-15 | 2016-03-23 | 赵国贤 | Quick-acting hypnotic soup |
| CN105379914A (en) * | 2015-12-17 | 2016-03-09 | 济南舜祥医药科技有限公司 | Health tea for treatment of insomnia |
| CN107137646A (en) * | 2017-06-07 | 2017-09-08 | 陈胤峰 | A kind of seedling medicine for the treatment of of insomnia patients |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1399986A (en) * | 2001-07-27 | 2003-03-05 | 张树贵 | Medicine for curing sleepless |
| CN1493353A (en) * | 2003-09-18 | 2004-05-05 | 江苏扬子江药业集团有限公司 | Chinese compound medicine for treating anhypnosis and its preparation metod |
| CN1679909A (en) * | 2005-01-26 | 2005-10-12 | 陈卫辉 | Chinese medicine composition for treating hyposomnia and preparation thereof |
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2008
- 2008-02-17 CN CN2008100814786A patent/CN101244195B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1399986A (en) * | 2001-07-27 | 2003-03-05 | 张树贵 | Medicine for curing sleepless |
| CN1493353A (en) * | 2003-09-18 | 2004-05-05 | 江苏扬子江药业集团有限公司 | Chinese compound medicine for treating anhypnosis and its preparation metod |
| CN1679909A (en) * | 2005-01-26 | 2005-10-12 | 陈卫辉 | Chinese medicine composition for treating hyposomnia and preparation thereof |
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