CN1679909A - Chinese medicine composition for treating hyposomnia and preparation thereof - Google Patents
Chinese medicine composition for treating hyposomnia and preparation thereof Download PDFInfo
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- CN1679909A CN1679909A CN 200510049220 CN200510049220A CN1679909A CN 1679909 A CN1679909 A CN 1679909A CN 200510049220 CN200510049220 CN 200510049220 CN 200510049220 A CN200510049220 A CN 200510049220A CN 1679909 A CN1679909 A CN 1679909A
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Abstract
A Chinese medicine in the form of particles for treating insomnia is prepared from 10 Chinese-medicinal materials including wild jujube, fleece flower stem, Chinese angelica root, ganoderma, etc through proportional mixing, immersing, heating, extracting, decocting, hydrolysis, including, concentrating, drying and granulating.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, be specifically related to a kind of Chinese medicine composition and production method thereof of Cure for insomnia disease.
Background technology
With the quickening pace of modern life, and from the pressure of aspects such as society, family, make people in psychology be in a kind of fatigue state of anxiety mentally, in the course of time, just close and insomnia, shortness of breath and palpitation, anorexia, lassitude, forgetful, symptom such as health is weak occur.These symptoms all produce very big influence to patient's life, work, study, also may bring out symptoms such as anxiety, depression.Clinically now some Western medicine tranquilizer that adopt as medicines such as stable, secobarbitals, though they can play a period of time and act on, can not be eradicated old complaint more.Along with the course of disease prolongs, the people knows from experience the generation drug resistance, needs constantly to increase dose, or changes the stronger calm medicine of the efficacy of a drug, causes the dependence to medicine.Control that Western medicine tranquilizer Cure for insomnia is just passive or pressure sleep can not improve sleep quality.And chemical tranquilizer has toxic and side effects to neural, liver.Some Chinese patent medicines are also arranged now clinically, on curative effect, do not obtain gratifying effect as BUXIN DAN, Cinnabar Sedative Pill etc.
Summary of the invention
The object of the present invention is to provide a kind of compatibility proper treatment insomnia's the Chinese medicine composition and the technical scheme of production method thereof, therapeutic effect is good, have no side effect.
The Chinese medicine composition of described Cure for insomnia disease is characterized in that by comprising that following raw materials by weight proportions makes:
Semen Ziziphi Spinosae 10-16, Caulis Polygoni Multiflori 5-11, Radix Polygalae 8-14, Radix Angelicae Sinensis 7-13, Radix Rehmanniae 8-14, Poria 5-11, Rhizoma Acori Graminei 5-11, Concha Margaritifera 9-15, Ganoderma 8-14, Radix Ophiopogonis 5-11.
The production method of described Chinese medicine composition is characterized in that comprising following processing step:
(1), Radix Angelicae Sinensis, Rhizoma Acori Graminei add 6-10 times of water gaging, soaked 0.5-2 hour, reflux 3-5 hour, extract volatile oil, put coldly, collect volatile oil, Aromatic water, medicinal residues and medicinal liquid are standby;
(2), getting Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Radix Rehmanniae, Radix Polygalae, Poria, Ganoderma, Radix Ophiopogonis mixes with medicinal residues and medicinal liquid behind Radix Angelicae Sinensis, the Rhizoma Acori Gramineii extract volatile oil, extracting in water twice adds 9-11 times of water gaging for the first time, decocts 1-3 hour, add for the second time 7-9 times of water gaging, decocted 0.5-1.5 hour, it is 1.05-1.45 that filtrate is concentrated into relative density, adds ethanol and is 60-80% to containing the alcohol amount, placed 45-50 hour, filter, reclaim ethanol, medicinal liquid is standby;
(3), Concha Margaritifera adds the 2-4mol/LH that 6-8 doubly measures
2SO
4Back hydrolysis 4-6 hour, to filter, filtrate adds CaCO
3Transfer hydrolyzed solution to neutral, filter, the filtrate heating is concentrated into and contains crude drug amount 8-12%, and is standby;
(4), volatile oil adds beta-schardinger dextrin-and carries out enclose, volatile oil: beta-schardinger dextrin-=1: 9-11,35-45 ℃ dry 1.5-3 hour down, standby; Aromatic water adds beta-schardinger dextrin-and carries out enclose, Aromatic water: beta-schardinger dextrin-=3-5: 1, and temperature: 35-45 ℃, mixing speed: 260-340r/min, enclose 2-4 hour, standby;
(5), the decocting medicinal liquid of step (2) and the hydrolyzed solution of step (3) are merged, concentrating under reduced pressure, the clathrate that adds Aromatic water and beta-schardinger dextrin-, being concentrated into relative density is 0.85-1.58, spray drying, get fine powder, the clathrate that adds volatile oil and beta-schardinger dextrin-again, technology adds dextrin routinely then, sweeting agent is an amount of, mixing, make soft material with 70-90% ethanol, granulation, drying.
Chinese medicine composition of the present invention has nourishing YIN and supplementing blood, the effect such as calm the nerves of reducing phlegm.Cure mainly: deficiency of YIN-blood, lack of preservation of spirit, the insomnia that the turbid retardance of expectorant causes.This Chinese medicine composition can improve the specificity of medication greatly, and the curative effect of medication of other treatment congenerous disease has large increase, has no side effect relatively.And, the present invention's uniqueness of filling a prescription, evident in efficacy, production method is simple.
Proportioning that relates among the present invention and percentage composition thereof are all by weight.
The specific embodiment
Example formulations:
Semen Ziziphi Spinosae 13, Caulis Polygoni Multiflori 8, Radix Polygalae 11, Radix Angelicae Sinensis 10, Radix Rehmanniae 11, Poria 8, Rhizoma Acori Graminei 8, Concha Margaritifera 12, Ganoderma 11, Radix Ophiopogonis 8.
This Chinese medicine composition makes according to following process by above-mentioned prescription:
(1), Radix Angelicae Sinensis, Rhizoma Acori Graminei add 8 times of water gagings, soaked 1 hour, reflux 4 hours is extracted volatile oil, puts coldly, collects volatile oil, Aromatic water, medicinal residues and medicinal liquid are standby;
(2), getting Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Radix Rehmanniae, Radix Polygalae, Poria, Ganoderma, Radix Ophiopogonis mixes with medicinal residues and medicinal liquid behind Radix Angelicae Sinensis, the Rhizoma Acori Gramineii extract volatile oil, extracting in water twice adds 10 times of water gagings for the first time, decocts 2 hours, add for the second time 8 times of water gagings, decocted 1 hour, it is 1.20-1.25 that filtrate is concentrated into relative density, and adding ethanol is 70% to containing the alcohol amount, placed 48 hours, filter, reclaim ethanol, medicinal liquid is standby;
(3), Concha Margaritifera adds the 3mol/LH of 7 times of amounts
2SO
4Back hydrolysis 5 hours filters, and filtrate adds CaCO
3Transfer hydrolyzed solution pH value to 7, filter, the filtrate heating is concentrated into and contains crude drug amount 10%, and is standby;
(4), volatile oil adds beta-schardinger dextrin-and carries out enclose, volatile oil: beta-schardinger dextrin-=1: 10,40 ℃ dry 2 hours down, standby; Aromatic water adds beta-schardinger dextrin-and carries out enclose, Aromatic water: beta-schardinger dextrin-=4: 1, and temperature: 40 ℃, mixing speed: 300r/min, enclose 3 hours, standby;
(5), the decocting medicinal liquid of step (2) and the hydrolyzed solution of step (3) are merged, concentrating under reduced pressure, the clathrate that adds Aromatic water and beta-schardinger dextrin-, being concentrated into relative density is 1.05-1.08, spray drying, get fine powder, the clathrate that adds volatile oil and beta-schardinger dextrin-again, technology adds dextrin routinely then, sweeting agent is an amount of, mixing, make soft material with 80-85% ethanol, granulation, drying.
The function of this Chinese medicine composition: nourishing YIN and supplementing blood, the effect such as calm the nerves of reducing phlegm.Cure mainly: deficiency of YIN-blood, lack of preservation of spirit, the insomnia of the turbid retardance of expectorant.10 grams/time, 2 times/day, take after mixing it with water.
Below by test the example further set forth Chinese medicine composition of the present invention (to call the making mind calm granule in the following text) beneficial effect.
Pharmacodynamic test of active extract result
Test according to a conventional method, the result shows that oral making mind calm granule 60g/k and 30g/kg can obviously reduce the autonomic activities of normal mouse and the excited mice of amfetamine, prolong the length of one's sleep that pentobarbital sodium causes, shorten hypnosis incubation period and pentobarbital subliminal hypnosis dosage and have the obvious synergistic effect.And obviously prolong the incubation period that central stimulant dimefline and nikethamide induced mice are fainted from fear, obviously suppress nikethamide and cause the convulsions mortality of mice, improve the nikethamide half lethal dose.The result show the making mind calm granule to intact animal and central excitation animal tangible calmness all arranged, calm the nerves, anticonvulsant action, cure mainly with its function and to match.
Making mind calm granule mice mtd test
Test material: anthology invention medicine making mind calm granule.
Test method: the maximum dosage of mice is 804g/kg (crude drug), is equivalent to recommend 419 times of clinical consumption.
Result of the test: this dosage obviously suppresses the spontaneous activity of mice, but does not cause that animal is sleeping, does not cause animal dead, does not also have other tangible acute toxicity performance.
Making mind calm granule rat long term toxicity test
Test material: anthology invention medicine making mind calm granule.
Test method: the rat dosage is respectively 100g/kg, 50g/kg and 25g/kg, is equivalent to 52,26 and 13 times of clinical recommendation consumption respectively, continuous irrigation stomach 3 months.
Result of the test: each dosage of making mind calm granule slightly promotes the male rat body weight gain in whole test in the phase, the general state of rat, food-intake etc. all there is not obviously influence, packed cell volume and platelet slightly increase, the serum biochemistry index of reaction liver, renal function is not all had obvious harmful effect each period in test, the weight and the tissue morphology of each main organs do not had significant toxic action yet.Heavy dose of long term administration does not have tangible chronic toxicity infringement to rat.
Above-mentioned various test shows: this Chinese medicine composition, human body there is not toxic and side effects, and can not produce dependency and drug resistance, can significantly improve insomnia.
Claims (7)
1, the Chinese medicine composition of Cure for insomnia disease is characterized in that by comprising that following raw materials by weight proportions makes:
Semen Ziziphi Spinosae 10-16, Caulis Polygoni Multiflori 5-11, Radix Polygalae 8-14, Radix Angelicae Sinensis 7-13, Radix Rehmanniae 8-14, Poria 5-11, Rhizoma Acori Graminei 5-11, Concha Margaritifera 9-15, Ganoderma 8-14, Radix Ophiopogonis 5-11.
2, the Chinese medicine composition of Cure for insomnia disease as claimed in claim 1 is characterized in that the optimization weight proportion of each crude drug is:
Semen Ziziphi Spinosae 12-14, Caulis Polygoni Multiflori 7-9, Radix Polygalae 10-12, Radix Angelicae Sinensis 9-11, Radix Rehmanniae 10-12, Poria 7-9, Rhizoma Acori Graminei 7-9, Concha Margaritifera 11-13, Ganoderma 10-12, Radix Ophiopogonis 7-9.
3, the Chinese medicine composition of Cure for insomnia disease as claimed in claim 1 is characterized in that the optimum weight proportioning of each crude drug is:
Semen Ziziphi Spinosae 13, Caulis Polygoni Multiflori 8, Radix Polygalae 11, Radix Angelicae Sinensis 10, Radix Rehmanniae 11, Poria 8, Rhizoma Acori Graminei 8, Concha Margaritifera 12, Ganoderma 11, Radix Ophiopogonis 8.
4,, it is characterized in that described medicament is the above a dosage form of any pharmaceutics as the Chinese medicine composition of claim 1,2 or 3 described Cure for insomnia diseases.
5,, it is characterized in that described medicament is a granular preparation as the Chinese medicine composition of claim 1,2 or 3 described Cure for insomnia diseases.
6, the production method of Chinese medicine composition as claimed in claim 5 is characterized in that comprising following processing step:
(1), Radix Angelicae Sinensis, Rhizoma Acori Graminei add 6-10 times of water gaging, soaked 0.5-2 hour, reflux 3-5 hour, extract volatile oil, put coldly, collect volatile oil, Aromatic water, medicinal residues and medicinal liquid are standby;
(2), getting Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Radix Rehmanniae, Radix Polygalae, Poria, Ganoderma, Radix Ophiopogonis mixes with medicinal residues and medicinal liquid behind Radix Angelicae Sinensis, the Rhizoma Acori Gramineii extract volatile oil, extracting in water twice adds 9-11 times of water gaging for the first time, decocts 1-3 hour, add for the second time 7-9 times of water gaging, decocted 0.5-1.5 hour, it is 1.05-1.45 that filtrate is concentrated into relative density, adds ethanol and is 60-80% to containing the alcohol amount, placed 45-50 hour, filter, reclaim ethanol, medicinal liquid is standby;
(3), Concha Margaritifera adds the 2-4mol/LH that 6-8 doubly measures
2SO
4Back hydrolysis 4-6 hour, to filter, filtrate adds CaCO
3Transfer hydrolyzed solution to neutral, filter, the filtrate heating is concentrated into and contains crude drug amount 8-12%, and is standby;
(4), volatile oil adds beta-schardinger dextrin-and carries out enclose, volatile oil: beta-schardinger dextrin-=1: 9-11,35-45 ℃ dry 1.5-3 hour down, standby; Aromatic water adds beta-schardinger dextrin-and carries out enclose, Aromatic water: beta-schardinger dextrin-=3-5: 1, and temperature: 35-45 ℃, mixing speed: 260-340r/min, enclose 2-4 hour, standby;
(5), the decocting medicinal liquid of step (2) and the hydrolyzed solution of step (3) are merged, concentrating under reduced pressure, the clathrate that adds Aromatic water and beta-schardinger dextrin-, being concentrated into relative density is 0.85-1.58, spray drying, get fine powder, the clathrate that adds volatile oil and beta-schardinger dextrin-again, technology adds dextrin routinely then, sweeting agent is an amount of, mixing, make soft material with 70-90% ethanol, granulation, drying.
7, the production method of Chinese medicine composition as claimed in claim 6 is characterized in that comprising following processing step:
(1), Radix Angelicae Sinensis, Rhizoma Acori Graminei add 8 times of water gagings, soaked 1 hour, reflux 4 hours is extracted volatile oil, puts coldly, collects volatile oil, Aromatic water, medicinal residues and medicinal liquid are standby;
(2), getting Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Radix Rehmanniae, Radix Polygalae, Poria, Ganoderma, Radix Ophiopogonis mixes with medicinal residues and medicinal liquid behind Radix Angelicae Sinensis, the Rhizoma Acori Gramineii extract volatile oil, extracting in water twice adds 10 times of water gagings for the first time, decocts 2 hours, add for the second time 8 times of water gagings, decocted 1 hour, it is 1.20-1.25 that filtrate is concentrated into relative density, and adding ethanol is 70% to containing the alcohol amount, placed 48 hours, filter, reclaim ethanol, medicinal liquid is standby;
(3), Concha Margaritifera adds the 3mol/LH of 7 times of amounts
2SO
4Back hydrolysis 5 hours filters, and filtrate adds CaCO
3Transfer hydrolyzed solution pH value to 7, filter, the filtrate heating is concentrated into and contains crude drug amount 10%, and is standby;
(4), volatile oil adds beta-schardinger dextrin-and carries out enclose, volatile oil: beta-schardinger dextrin-=1: 10,40 ℃ dry 2 hours down, standby; Aromatic water adds beta-schardinger dextrin-and carries out enclose, Aromatic water: beta-schardinger dextrin-=4: 1, and temperature: 40 ℃, mixing speed: 300r/min, enclose 3 hours, standby;
(5), the decocting medicinal liquid of step (2) and the hydrolyzed solution of step (3) are merged, concentrating under reduced pressure, the clathrate that adds Aromatic water and beta-schardinger dextrin-, being concentrated into relative density is 1.05-1.08, spray drying, get fine powder, the clathrate that adds volatile oil and beta-schardinger dextrin-again, technology adds dextrin routinely then, sweeting agent is an amount of, mixing, make soft material with 80-85% ethanol, granulation, drying.
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| CN 200510049220 CN1679909A (en) | 2005-01-26 | 2005-01-26 | Chinese medicine composition for treating hyposomnia and preparation thereof |
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| CN 200510049220 CN1679909A (en) | 2005-01-26 | 2005-01-26 | Chinese medicine composition for treating hyposomnia and preparation thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129633B (en) * | 2007-09-19 | 2010-05-19 | 吉林省辉南天宇药业股份有限公司 | Medicine for neurasthenia and its preparation |
| CN101244195B (en) * | 2008-02-17 | 2010-12-22 | 李毅 | Medicament for treating aypnia |
| CN102327464A (en) * | 2011-10-10 | 2012-01-25 | 张运林 | Medicament for treating insomnia |
| CN101485796B (en) * | 2008-01-14 | 2013-05-29 | 北京亚东生物制药有限公司 | Chinese medicinal composition for treating insomnia as well as preparation method thereof |
| CN103251796A (en) * | 2013-04-22 | 2013-08-21 | 于祝先 | Traditional Chinese medicine for treating insomnia |
| CN104784527A (en) * | 2015-04-02 | 2015-07-22 | 韩桂莲 | Heart-calming mind-tranquilizing drug for treating insomnia and preparation method of heart-calming mind-tranquilizing drug |
| CN105853714A (en) * | 2016-06-22 | 2016-08-17 | 吴淑芬 | Traditional Chinese medicine composition for treating insomnia |
| CN107714861A (en) * | 2016-08-11 | 2018-02-23 | 孙辅 | A kind of medicine for treating middle-aged and old cerebral senility |
-
2005
- 2005-01-26 CN CN 200510049220 patent/CN1679909A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129633B (en) * | 2007-09-19 | 2010-05-19 | 吉林省辉南天宇药业股份有限公司 | Medicine for neurasthenia and its preparation |
| CN101485796B (en) * | 2008-01-14 | 2013-05-29 | 北京亚东生物制药有限公司 | Chinese medicinal composition for treating insomnia as well as preparation method thereof |
| CN101244195B (en) * | 2008-02-17 | 2010-12-22 | 李毅 | Medicament for treating aypnia |
| CN102327464A (en) * | 2011-10-10 | 2012-01-25 | 张运林 | Medicament for treating insomnia |
| CN103251796A (en) * | 2013-04-22 | 2013-08-21 | 于祝先 | Traditional Chinese medicine for treating insomnia |
| CN103251796B (en) * | 2013-04-22 | 2014-10-29 | 于祝先 | Traditional Chinese medicine for treating insomnia |
| CN104784527A (en) * | 2015-04-02 | 2015-07-22 | 韩桂莲 | Heart-calming mind-tranquilizing drug for treating insomnia and preparation method of heart-calming mind-tranquilizing drug |
| CN105853714A (en) * | 2016-06-22 | 2016-08-17 | 吴淑芬 | Traditional Chinese medicine composition for treating insomnia |
| CN107714861A (en) * | 2016-08-11 | 2018-02-23 | 孙辅 | A kind of medicine for treating middle-aged and old cerebral senility |
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