CN102988587A - Medicament for treating refractory insomnia and preparation method of medicament - Google Patents
Medicament for treating refractory insomnia and preparation method of medicament Download PDFInfo
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- CN102988587A CN102988587A CN 201210469199 CN201210469199A CN102988587A CN 102988587 A CN102988587 A CN 102988587A CN 201210469199 CN201210469199 CN 201210469199 CN 201210469199 A CN201210469199 A CN 201210469199A CN 102988587 A CN102988587 A CN 102988587A
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Abstract
The invention discloses a medicament for treating refractory insomnia and a preparation method of the medicament. The medicament comprises the following active ingredients in parts by weight: 10-30 parts of astragalus mongholicus, 5-15 parts of Chinese angelica, 5-15 parts of dried rehamnnia roots, 5-15 parts of prepared rehmannia roots, 2-15 parts of golden threads, 5-15 parts of skullcap, 15-25 parts of crude dragon bones, 15-25 parts of raw oyster shells and 2-15 parts of poria with hostwood. The method for preparing the medicament comprises the following steps of: weighing each active ingredient for later use; adding water into the active ingredients to decoct for twice; filtering after each decoction to obtain a filtering liquid; combining the filtering liquids obtained for twice; and concentrating at reduced pressure to obtain extract with crude drug of 5g/ml so as to obtain the medicament for treating the cold. The medicament has the advantages that the formula is scientific, and the curative effect of the medicament is obvious, and the problem that the insomnia is easy to be addicted can be effectively solved.
Description
Technical field
The present invention relates to the Chinese medicine technical field, be specifically related to a kind of medicine for the treatment of intractable insomnia and preparation method thereof.
Background technology
In recent years, along with social development, competition is aggravation constantly, and people's survival pressure continues to increase, and the sickness rate of insomnia is the trend of rising.The insomnia be with sleeping and (or) sleep keeps that sleep quality due to the difficulty or quantity do not reach the normal physiological demand and a kind of subjective experience that affect the social function on daytime is the most common a kind of sleep disordered disease.The insomnia is difficulty falling asleep or rear easy the waking up of sleeping, and accompanies weak dizziness, dysphoria with smothery sensation, xerostomia wish drink, and dreaminess is felt without sleep, and sleep dark and early awakening do not recover from fatigue after waking up etc.Because insomnia and excessively probably all has formed a vicious cycle repeatedly, the irritated sleeplessness of patient at night, even uneasy in either sitting or lying, dizziness, extreme cold of the limbs, irritability and self is too paid close attention to etc.The Chinese medicine and western medicine of Cure for insomnia is of a great variety at present, doctor trained in Western medicine is main mainly with barbital, Benzodiazepines, Non-benzodiazepine sedative hypnotic in treatment, but these medicines cause easily dependency and easily cause drug withdrawal syndrome, so the Chinese medicine insomnia just demonstrates obvious advantage.But these medicines of long-term taking are habit-forming easily, and dependency is very strong, in case easily bounce-back after the drug withdrawal.
Summary of the invention
Goal of the invention: the first purpose of the present invention is to overcome the deficiencies in the prior art, and a kind of safe and reliable, medicine of having no side effect, being difficult for the treatment intractable insomnia of bounce-back is provided.
The second purpose of the present invention is to provide a kind of above-mentioned preparation method that is used for the treatment of the medicine of intractable insomnia.
Technical scheme: in order to solve above-mentioned the first purpose, the technical solution adopted in the present invention is: a kind of medicine that is used for the treatment of intractable insomnia comprises the crude drug of following parts by weight: Radix Astragali 10-30 part, Radix Angelicae Sinensis 5-15 part, Radix Rehmanniae 5-15 part, Radix Rehmanniae Preparata 5-15 part, Rhizoma Coptidis 2-15 part, Radix Scutellariae 5-15 part, Os Draconis 15-25 part, Concha Ostreae 15-25 part, Poria cum Radix Pini 2-15 part.
Preferably, the crude drug that comprises following parts by weight: 20 parts of the Radixs Astragali, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Rehmanniae, 10 parts of Radix Rehmanniae Preparata, 8 parts of Rhizoma Coptidis, 10 parts of Radix Scutellariae, 20 parts of Os Draconis, 20 parts of Concha Ostreae, 8 parts of Poria cum Radix Pinis.
In order to solve above-mentioned the second purpose, the technical solution adopted in the present invention is: a kind of preparation method that is used for the treatment of the medicine of intractable insomnia is characterized in that the method comprises the steps:
(1) according to following parts by weight weighting raw materials: Radix Astragali 10-30 part, Radix Angelicae Sinensis 5-15 part, Radix Rehmanniae 5-15 part, Radix Rehmanniae Preparata 5-15 part, Rhizoma Coptidis 2-15 part, Radix Scutellariae 5-15 part, Os Draconis 15-25 part, Concha Ostreae 15-25 part, Poria cum Radix Pini 2-15 part; For subsequent use;
(2) above-mentioned each crude drug is decocted with water twice, for the first time amount of water is 3～5 times of crude drug gross weight, decoct and extract 1h, for the second time amount of water is 2～3 times of crude drug gross weight, decocts and extracts 30min, all filters after each the decoction, get filtrate, merge filtrate twice, be evaporated to the extractum that contains 5g crude drug/ml, namely get the medicine of described treatment intractable insomnia.
Beneficial effect: compared with prior art, advantage of the present invention is: scientific formulation, can improve effective ingredient amount in the product, and prove that medicine evident in efficacy can obviously solve easily habit-forming problem of insomnia through clinical use.
The specific embodiment
According to following embodiment, the present invention may be better understood.Yet, those skilled in the art will readily understand that the described concrete technology path of embodiment and result thereof only are used for explanation the present invention, and should also can not limit the present invention described in detail in claims.
Embodiment 1:
A kind of medicine for the treatment of intractable insomnia is mainly made by the crude drug of following parts by weight: 20 parts of the Radixs Astragali, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Rehmanniae, 10 parts of Radix Rehmanniae Preparata, 8 parts of Rhizoma Coptidis, 10 parts of Radix Scutellariae, 20 parts of Os Draconis, 20 parts of Concha Ostreae, 8 parts of Poria cum Radix Pinis.
At first according to following parts by weight weighting raw materials, then above-mentioned each crude drug is decocted with water twice, for the first time amount of water is 5 times of crude drug gross weight, decocts and extracts 1h, and amount of water is 3 times of crude drug gross weight for the second time, decoct and extract 30min, all filter after each the decoction, get filtrate, merge filtrate twice, be evaporated to the extractum that contains 5g crude drug/ml, namely get the medicine of described treatment intractable insomnia.
Embodiment 2:
A kind of medicine for the treatment of intractable insomnia is mainly made by the crude drug of following parts by weight: 15 parts of the Radixs Astragali, 8 parts of Radix Angelicae Sinensis, 8 parts of Radix Rehmanniae, 8 parts of Radix Rehmanniae Preparata, 6 parts of Rhizoma Coptidis, 8 parts of Radix Scutellariae, 20 parts of Os Draconis, 20 parts of Concha Ostreae, 6 parts of Poria cum Radix Pinis; For subsequent use;
At first according to following parts by weight weighting raw materials, then above-mentioned each crude drug is decocted with water twice, for the first time amount of water is 3 times of crude drug gross weight, decocts and extracts 1h, and amount of water is 2 times of crude drug gross weight for the second time, decoct and extract 30min, all filter after each the decoction, get filtrate, merge filtrate twice, be evaporated to the extractum that contains 5g crude drug/ml, namely get the medicine of described treatment flu.
Embodiment 3:
A kind of medicine for the treatment of intractable insomnia, mainly made by the crude drug of following parts by weight: 12 parts of the Radixs Astragali, 6 parts of Radix Angelicae Sinensis, 6 parts of Radix Rehmanniae, 7 parts of Radix Rehmanniae Preparata, 5 parts of Rhizoma Coptidis, 7 parts of Radix Scutellariae, 18 parts of Os Draconis, 18 parts of Concha Ostreae,
4 parts of Poria cum Radix Pinis; For subsequent use;
At first according to following parts by weight weighting raw materials, then above-mentioned each crude drug is decocted with water twice, for the first time amount of water is 4 times of crude drug gross weight, decocts and extracts 1h, and amount of water is 3 times of crude drug gross weight for the second time, decoct and extract 30min, all filter after each the decoction, get filtrate, merge filtrate twice, be evaporated to the extractum that contains 5g crude drug/ml, namely get the medicine of described treatment flu.
Further set forth beneficial effect of the present invention below by clinical trial.
Select 100 intractable insomnia patients to carry out system's clinical observation according to conditions of patients, the patient is divided into test group and matched group at random, every group of 50 people, test group is treated according to the prescription in embodiment 1 or the experimental example 2; Matched group is taken commercially available Western medicine A Pu mile logical sequence treatment;
Usage and dosage: be decocted in water for oral dose 2 times on the one.15 days is a course for the treatment of, totally 3 courses for the treatment of.
The curative effect of test group and matched group clinical trial is as shown in the table:
| Group | Case load | Produce effects | Effectively | Invalid | Total effective rate % |
| Test group | 50 | 20 | 28 | 2 | 96% |
| Matched group | 50 | 5 | 26 | 19 | 62% |
Test data in upper table statistics shows that take the patient of this medicine, what significant curative effect was arranged accounts for 40%, accounts for 10% and matched group has a significant curative effect, and hence one can see that, and test group has the matched group that is far longer than of significant curative effect, and the value of clinical expansion is arranged.
Claims (3)
1. medicine for the treatment of intractable insomnia, it is characterized in that, comprise the crude drug of following parts by weight: Radix Astragali 10-30 part, Radix Angelicae Sinensis 5-15 part, Radix Rehmanniae 5-15 part, Radix Rehmanniae Preparata 5-15 part, Rhizoma Coptidis 2-15 part, Radix Scutellariae 5-15 part, Os Draconis 15-25 part, Concha Ostreae 15-25 part, Poria cum Radix Pini 2-15 part.
2. a kind of medicine for the treatment of intractable insomnia according to claim 1, it is characterized in that, comprise the crude drug of following parts by weight: 20 parts of the Radixs Astragali, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Rehmanniae, 10 parts of Radix Rehmanniae Preparata, 8 parts of Rhizoma Coptidis, 10 parts of Radix Scutellariae, 20 parts of Os Draconis, 20 parts of Concha Ostreae, 8 parts of Poria cum Radix Pinis.
3. a kind of preparation method for the treatment of the medicine of intractable insomnia according to claim 1 is characterized in that the method comprises the steps:
(1) according to following parts by weight weighting raw materials: Radix Astragali 10-30 part, Radix Angelicae Sinensis 5-15 part, Radix Rehmanniae 5-15 part, Radix Rehmanniae Preparata 5-15 part, Rhizoma Coptidis 2-15 part, Radix Scutellariae 5-15 part, Os Draconis 15-25 part, Concha Ostreae 15-25 part, Poria cum Radix Pini 2-15 part; For subsequent use;
(2) above-mentioned each crude drug is decocted with water twice, for the first time amount of water is 3～5 times of crude drug gross weight, decoct and extract 1h, for the second time amount of water is 2～3 times of crude drug gross weight, decocts and extracts 30min, all filters after each the decoction, get filtrate, merge filtrate twice, be evaporated to the extractum that contains 5g crude drug/ml, namely get the medicine of described treatment intractable insomnia.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 201210469199 CN102988587A (en) | 2012-11-20 | 2012-11-20 | Medicament for treating refractory insomnia and preparation method of medicament |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201210469199 CN102988587A (en) | 2012-11-20 | 2012-11-20 | Medicament for treating refractory insomnia and preparation method of medicament |
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| CN102988587A true CN102988587A (en) | 2013-03-27 |
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| CN 201210469199 Pending CN102988587A (en) | 2012-11-20 | 2012-11-20 | Medicament for treating refractory insomnia and preparation method of medicament |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105521270A (en) * | 2016-01-29 | 2016-04-27 | 东华大学 | Traditional Chinese medicinal composition for treating refractory insomnia |
| CN105726933A (en) * | 2016-02-02 | 2016-07-06 | 东华大学 | Water pills and preparation method and application thereof |
-
2012
- 2012-11-20 CN CN 201210469199 patent/CN102988587A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105521270A (en) * | 2016-01-29 | 2016-04-27 | 东华大学 | Traditional Chinese medicinal composition for treating refractory insomnia |
| CN105726933A (en) * | 2016-02-02 | 2016-07-06 | 东华大学 | Water pills and preparation method and application thereof |
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Application publication date: 20130327 |