CN100394976C - Chinese medicine for withdrawal of drug dependence - Google Patents
Chinese medicine for withdrawal of drug dependence Download PDFInfo
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- CN100394976C CN100394976C CNB031282261A CN03128226A CN100394976C CN 100394976 C CN100394976 C CN 100394976C CN B031282261 A CNB031282261 A CN B031282261A CN 03128226 A CN03128226 A CN 03128226A CN 100394976 C CN100394976 C CN 100394976C
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Abstract
The present invention discloses a Chinese medicine for detoxification, which is prepared into pills by that Chinese herbal medicines of radix notoginseng, milkvetch root, corydalis tuber, Chinese eaglewood, ginseng, etc. are crushed in a classified way, sieved and mixed; then, honey and distilled water are added and uniformly mixed. The present invention has the advantages of stable curative effect, short treatment period, small toxic and side effect and low recurrence rate.
Description
Technical field
The present invention relates to a kind of anti-additive medicament that belongs to pure Chinese medicinal preparation, especially a kind of Narcotic Chinese medicine thing that is used for the treatment of opiate addiction the invention still further relates to the preparation method of this medicine.
Background technology
In recent years, the junkie ratio of sucking the opium drug addiction increases year by year, become serious social concern, drugs become the able-bodied killer of harm humans, junkie is rehabilitated addicts, removing accumulates in intravital toxin, reaches from physiology and the psychological thoroughly purpose of drug rehabilitation, has become the target that the medical personnel pursues with all strength.Drug rehabilitation method branch commonly used is at present given up taking addictive drugs by force and medicine drug rehabilitation two big classes, give up taking addictive drugs by force promptly without medicine, give up by force, needs of patients strong will, bear painful big, the general patient who only is applicable to that the drug abuse time is short, the amount of sucking is little, drug addiction is little and have a strong constitution, the scope of application is little, effect is not good enough: and the medicine drug rehabilitation is divided into substitution method, decrement method, hibernation method.Substitution method is to adopt the little Western medicine of addiction such as " methadone ", " dihydroetorphine hydrochlorate ", " buprenophine ", " dolantin " to substitute drugs to treat, though can rehabilitate addicts to a certain extent, the patient easily produces dependency to alternative medicine; The decrement method is to adopt the method that reduces the drugs amount of sucking gradually, and the patient is progressively rehabilitated addicts, but this method cycle is long, therapeutic effect is undesirable; The hibernation method is to adopt powerful tranquilizer to make the patient be in hibernation-like state and prevent the drug addiction outbreak, lowers the dependence of patient to drugs, but this method causes damage to patient's nervous system, or even irreversible permanent damage.In sum, all there is big, the drawback thorough, that relapse rate is high of rehabilitating addicts of curative effect instability, treatment cycle length, gastrointestinal tract and nervous system side effect in above-mentioned drug rehabilitation method commonly used.
Summary of the invention
Purpose of the present invention just provides that a kind of stable curative effect, short treating period, side effect are little, human body and psychological withdrawal is thorough, relapse rate is low, safe and reliable, with low cost pure Narcotic Chinese medicine thing.
Another object of the present invention provides the preparation method of this Narcotic Chinese medicine thing.
The object of the present invention is achieved like this:
Medicine of the present invention is made (consumption is a weight ratio) by following component:
Radix Notoginseng 180-220 Radix Astragali 270-330 Rhizoma Corydalis 720-880 Lignum Aquilariae Resinatum 360-440
Radix Puerariae 270-330 Rhizoma Atractylodis Macrocephalae 270-330 Pericarpium Papaveris 135-165 Radix Ginseng 180-220
Cortex Eucommiae 270-330 Bombyx Batryticatus 160-200 Flos Daturae 27-30 Radix Morindae Officinalis 160-200
Rhizoma Chuanxiong 325-395 Radix Curcumae Poria cum Radix Pini 325-395 160-200 Radix Trichosanthis 160-200
Succinum 90-110 Semen Strychni 27-30 Olibanum 360-440 Myrrha 360-440
Radix Dipsaci 360-440 Radix Paeoniae Alba 325-395 Rhizoma Gastrodiae 325-395 Sanguis Draxonis 180-220
Carapax Trionycis 450-550 Radix Aconiti Lateralis Preparata 160-200 Radix Angelicae Sinensis 360-440 Radix Salviae Miltiorrhizae 360-440
Flos Carthami 90-110 Pheretima 160-200 Carapax et Plastrum Testudinis 450-550 Herba Asari 160-200
Rhizoma Pinelliae 180-220 Rhizoma Et Radix Notopterygii 270-330 Rhizoma Curculiginis 270-330 Ramulus Uncariae Cum Uncis 270-330
Radix Glycyrrhizae 180-220 Radix Asparagi 180-220 Fructus Jujubae 90-110
The formula optimization weight proportion scope of preparation medicine of the present invention is:
Radix Notoginseng 190-210 Radix Astragali 280-330 Rhizoma Corydalis 730-870 Lignum Aquilariae Resinatum 370-420
Radix Puerariae 280-320 Rhizoma Atractylodis Macrocephalae 280-320 Pericarpium Papaveris 140-160 Radix Ginseng 190-210
Cortex Eucommiae 280-320 Bombyx Batryticatus 170-190 Flos Daturae 28-30 Radix Morindae Officinalis 170-190
Rhizoma Chuanxiong 330-390 Radix Curcumae Poria cum Radix Pini 330-390 170-190 Radix Trichosanthis 170-190
Succinum 90-100 Semen Strychni 28-30 Olibanum 370-430 Myrrha 370-430
Radix Dipsaci 370-430 Radix Paeoniae Alba 330-390 Rhizoma Gastrodiae 330-390 Sanguis Draxonis 190-210
Carapax Trionycis 460-540 Radix Aconiti Lateralis Preparata 170-190 Radix Angelicae Sinensis 370-430 Radix Salviae Miltiorrhizae 370-430
Flos Carthami 100-110 Pheretima 170-190 Carapax et Plastrum Testudinis 460-540 Herba Asari 170-190
Rhizoma Pinelliae 190-210 Rhizoma Et Radix Notopterygii 280-320 Rhizoma Curculiginis 280-320 Ramulus Uncariae Cum Uncis 280-320
Radix Glycyrrhizae 190-210 Radix Asparagi 190-210 Fructus Jujubae 90-100
The optimum weight proportioning of medicine of the present invention is:
Radix Notoginseng 200 Radixs Astragali 300 Rhizoma Corydalis 800 Lignum Aquilariae Resinatum 400
Radix Puerariae 300 Rhizoma Atractylodis Macrocephalaes 300 Pericarpium Papaveriss 150 Radix Ginsengs 200
The Cortex Eucommiae 300 Bombyx Batryticatus 180 Flos Daturaes 30 Radix Morindae Officinaliss 180
Rhizoma Chuanxiong 360 Radix Curcumaes 360 Poria cum Radix Pinis 180 Radix Trichosanthis 180
Succinum 100 Semen Strychni 30 Olibanums 400 Myrrhas 400
Radix Dipsaci 400 Radix Paeoniae Albas 360 Rhizoma Gastrodiaes 360 Sanguis Draxonis 200
Carapax Trionycis 500 Radix Aconiti Lateralis Preparatas 180 Radix Angelicae Sinensis 400 Radix Salviae Miltiorrhizaes 400
Flos Carthami 100 Pheretimas 180 Carapax et Plastrum Testudiniss 500 Herba Asaris 180
The Rhizoma Pinelliae 200 Rhizoma Et Radix Notopterygiis 300 Rhizoma Curculiginises 300 Ramulus Uncariae Cum Uncis 300
Radix Glycyrrhizae 200 Radix Asparagis 200 Fructus Jujubaes 100
Above-mentioned each component is made the medicine of the present invention that dosage form is a pill, and its preparation method is: after described raw material classification is pulverized, through sieving, mixing, add Mel and distilled water mixing, rubbing then, make pill.The directly pulverizing of succinum, Carapax et Plastrum Testudinis, Carapax Trionycis, Olibanum, Myrrha, Sanguis Draxonis are processed the back pulverizing in the described raw material, after processing, Bombyx Batryticatus, Pheretima, Semen Strychni, Radix Aconiti Lateralis Preparata, the Rhizoma Pinelliae grind into powder, Lignum Aquilariae Resinatum is adopted the rasion barreling, profits such as Rhizoma Gastrodiae, Radix Angelicae Sinensis, Radix Asparagi, Radix Ginseng, Radix Salviae Miltiorrhizae, the Radix Astragali are cut after drying and are pulverized, and cut off after Herba Asari, Rhizoma Curculiginis, Ramulus Uncariae Cum Uncis, Flos Carthami, Rhizoma Et Radix Notopterygii, the Radix Glycyrrhizae drying and pulverize.Cross 100 mesh sieves respectively after Semen Strychni, the Rhizoma Pinelliae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, succinum are pulverized in the described raw material, residue 34 flavor raw materials are crossed the 40-60 mesh sieve earlier, and behind 80 mesh sieves, described 39 flavor raw materials mix.Described Mel be heated to boiling and color when being brownish red 100% ratio in raw material weight add, distilled water is by the 30%-50% ratio adding of raw material weight.
Solution of the present invention is based on understanding and the Therapeutic Principle of Chinese medicine and pharmacy to opium drug addiction mechanism; achieve with reference to modern pharmacological research; choose blood circulation promoting and blood stasis dispelling, the strong kidney of being amusing, the kidney warming consolidate, detoxifying, removing dampness, analgesia are calmed the nerves, the natural edible-plant Chinese herbal medicine of strengthening vital QI to eliminate pathogenic factors; press the theoretical prescription of Chinese medicine; make its performance Chinese medicine detoxication and toxicant eliminating function thorough, little to gastrointestinal tract and cardiovascular system side effect; safeguard cardiovascular circulation system normal function; regulate meridians, the comprehensive function of protection internal organs.
Wherein, Radix Notoginseng contains the arasaponin alkaloid, blood circulation promoting and blood stasis dispelling, analgesic hemostatic, mainly curing cardiovascular systemic disease and various pain, angor, hemorrhage damage etc.; Radix Ginseng contains the rare class Saponin of triterpene, from ginseng glycoside, RB1, fruit acid, saccharide, strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promoting the production of body fluid and inducing sedation of the mind cure mainly collapse, the deficiency of vital energy etc., excited N maincenter, shock; The Radix Astragali contains saccharide, choline, folic acid, several aminoacid, B-sitosterol etc., tonifying Qi and lifting yang, benefit are defended consolidating superficial resistance, promoting pus discharge and tissue regeneration strengthening, excited N maincenter, disease resistance enhancemen, cardiotonic, blood vessel dilating are arranged, bring high blood pressure down, improve skin microcirculation, the liver protecting liver glycogen reduces, cure mainly a little less than deficiency of vital energy and physically weak, the blood deficiency gas; The Rhizoma Atractylodis Macrocephalae contains volatile oil, significantly lasting diuresis is arranged, and can promote the particularly discharge of sodium of electrolyte, blood sugar lowering, the liver protecting, invigorating the spleen and replenishing QI, dampness diuretic, strengthening superficial resistance to stop perspiration, cure mainly that diet reduces due to deficiency of spleen-QI and stomach-QI, the dysfunction of the spleen in transportation and transformation, fatigue and weakness and in the disease of burnt yang deficiency; Rhizoma Corydalis contains 15 kinds of alkaloids, and Rhizoma Corydalis second element, ugly element and first element have that tell, invigorate blood circulation in obvious analgesia and spasmolysis, loose muscle and town, promoting the circulation of QI to relieve pain, does not have toxicity, sleeps peacefully but cure mainly various pain antalgic and sedatives; Lignum Aquilariae Resinatum contains benzylacetone and to methoxybenzyl benzylacetone, the rare alcohols of terpene and cinnamic acid, promoting the circulation of QI to relieve pain, wet in cold expelling, lowering the adverse QI to relieve asthma, cure mainly the breast gastral cavity and expand and have a pain, suffer from abdominal pain; Radix Puerariae contains flavonoid and starch; analgesic expelling pathogenic factors from muscles, blood sugar lowering, hypotensive activity are arranged; effectively improve cerebral circulation and circulation on every side; the intravenous injection pituitrin is caused that the acute myocardial ischemia reaction has protective effect; expelling pathogenic factors from muscles, yang invigorating, promote the production of body fluid, cure mainly diseases such as stiff nape and back, diabetes and headache, dizziness, numb limbs and tense tendons.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, to select the natural edible Chinese herbal medicine for use be raw material in the present invention, and each component meets Pharmacopoeia of People's Republic of China nineteen ninety-five version regulation.Utilize the comprehensive pharmacological action treatment opiate addiction patient of the Chinese medicine of respectively distinguishing the flavor of, toxic and side effects is little, can not cause permanent damage to cardiovascular system, central nervous system, internal organs.
2, outward appearance rounding of the present invention is even, color and luster is consistent; weight differential ± 8%; content uniformity ± 4%; moisture content limit 9% is no more than 60 minutes disintegration, meets first inspection item regulation of Pharmacopoeia of People's Republic of China nineteen ninety-five version; take conveniently; nutritious, can strengthen patient's body constitution in the time of treatment, help the normal function of physical recovery.
3, medicine of the present invention contains multiple medicinal ingredients such as arasaponin alkaloid, the rare class Saponin of triterpene, aminoacid, choline, folic acid, multiple alkaloid, benzylacetone, flavone; effectively improve the circulation of cardiovascular and brain, the liver protecting, detoxication and toxicant eliminating function, stable curative effect, short treating period.
4, medicine of the present invention can replace expensive Western medicine, can thoroughly give up patient's drug addiction, and can not cause the dependence to medicine of the present invention, and from physiology with give up drug addiction psychologically, relapse rate is low, and treats with low cost.
For showing the therapeutic effect of medicine of the present invention to opiate addiction, 18 routine opiate addiction class patients are treated observation, be 7-15 days the course of treatment, average 11 ± 4 days.Relatively, this invention medicine is evident in efficacy to removing the opium withdrawal symptom before and after the treatment; Especially to the appearance of cardinal symptoms such as pain management, insomnia and remove the patient anxiety, depressive state is more outstanding, solved the physiological dependence problem of patient to drugs, naloxone urges addiction not have obvious withdrawal symptom appearance, observes after the drug withdrawal, does not have this drug dependence and occurs.The 7-10 days check urine drugs analysis of taking medicine is all negative.Do not find any toxic and side effects, be emotionally stable after 18 routine patients take medicine not have and give up misery, appetite increases, antisecosis, average weight increase 2.1Kg.
Onset time: in 18 examples the fastest 10 minutes, the slowest 18 minutes, on average about onset in 14-15 minute.
Experimenter's situation:
Numbering take drugs every day at sex age total amount suck mode history of drug abuse (year) last take drugs to dosing interval (time) quit drug abuse number of times course of treatment (my god)
1 male 20 dolantin 100mg po 5,/12 10 08
2 women 18 morphine 15mg po 8,/12 707
3 women 32 morphine 40mg po 2.3/12 41 12
4 male 38 heroin 6g po v 5.7/12 41 12
5 male 34 heroin 5g v 6.7/12 43 15
6 male 36 heroin 2.5g po v 3.6/12 54 14
7 male 24 dolantin 600mg v 1.2/12 41 15
8 male 20 heroin 6g v 6.4/12 70 15
9 male 23 heroin 3g v 3.2/12 52 15
10 women 16 dolantin 300mg po 6,/12 52 15
11 male 27 heroin 3g v 6.8/12 708
12 women 19 dolantin 100mg po 5,/12 55 15
13 male 21 dolantin 150mg po 8,/12 70 12
14 male 22 dolantin 400mg v 1.2/12 50 15
15 women 18 dolantin 400mg po 10,/12 60 14
16 women 19 dolantin 400mg po v 1.3/12 60 14
17 male 43 heroin 6g v 6.3/12 50 15
18 male 32 heroin 3.5g v 833 15
Diagnostic criteria: 1, certain drug abuse medical history 2, have that withdrawal symptom occurs 3, the analysis of urine drugs is (+)
18 routine experimenters all meet above diagnostic criteria, have all carried out every routine examination after being admitted to hospital, and have got rid of body complication, infectious disease and psychosis.
The onset standard is measured in time: above experimenter all begins to take medicine at the main performance outbreak rear of withdrawal symptom, as: gape, perspiration, watery nasal discharge shed tears, shiver with cold spasm, fidgety cardiopalmus, worm climbed formication etc., treats that above transference cure is as the criterion computation time.
Clinical effective standard: withdrawal symptom is alleviated after the medication.
Clinical produce effects standard: withdrawal symptom disappears after the medication, does not occur repeatedly after rationally subtracting medicine.
The clinical cure standard:
1, drug withdrawal is after 1 day, and no withdrawal symptom occurs in the naloxone 0.4-0.8mg intramuscular injection 1 hour.
2, the urine drugs detect (one).
3, body No Poison demand and dependence.
4, spirit is emotionally stable, and the diet sleep is normal, and muscle power has certain recovery.
18 routine experimenters all reached the clinical cure standard within 15 days.
The clinical practice of medicine
1-3 days, 12g/ time, every 3-4 hour/time, every day accumulated dose 60-80g;
4-10 days, 6-12g/ time, every 6-8 hour/time, every day accumulated dose 20-40g;
10-15 days, 6g/ time, every 8-12 hour/time, every day accumulated dose 10-20g.
Should under physician guidance, take after mixing it with water at every turn, fasting Semen phaseoli radiati in taking medicine, prohibit the water of drinking tea, anemia of pregnant woman and bleeder's forbidding with hot brown sugar water.
Therapeutic evaluation:
Medicine of the present invention can obviously be alleviated opiomaniac's withdrawal symptom, the onset in back 15 minutes of generally taking medicine, and majority can be kept 3-5 hour.Withdrawal symptom 46 ± 21 treatment backs 1 ± 2 of keeping the score before the 18 routine patient, the two comparing difference is (P＜0.001) significantly, medication treatment 1-3 days with treatment before more equal P＜0.01, naloxone is urged and is kept the score after the addiction and treat doomsday comparison P＞0.05 of keeping the score.
18 routine experimenters' treatment with treat after follow up a case by regular visits to, find no the untoward reaction of medicine so far, in the treatment vital sign all in normal range, no significant difference before and after the medication.Medication bleeding from anus routine urinalysis, all no abnormal variation of liver function.When 18 routine experimenters finished in treatment, all drug withdrawals were smoothly followed up a case by regular visits to the mind ﹠ body of not seeing so far medicine of the present invention and are relied on phenomenon.
The urine drugs detect: this time we all select for use urine to test positive person to participate in and tried, the treatment through 7-10 days, and the check urine sample is all negative, and check once more was still negative after treatment finished.
The specific embodiment
Below in conjunction with embodiment the present invention is further described.
Embodiment 1
Take by weighing raw material by following weight proportion
Radix Notoginseng 180 Radixs Astragali 270 Rhizoma Corydalis 720 Lignum Aquilariae Resinatum 360
Radix Puerariae 270 Rhizoma Atractylodis Macrocephalaes 270 Pericarpium Papaveriss 135 Radix Ginsengs 180
The Cortex Eucommiae 270 Bombyx Batryticatus 160 Flos Daturaes 27 Radix Morindae Officinaliss 160
Rhizoma Chuanxiong 325 Radix Curcumaes 325 Poria cum Radix Pinis 160 Radix Trichosanthis 160
Succinum 90 Semen Strychni 27 Olibanums 360 Myrrhas 360
Radix Dipsaci 360 Radix Paeoniae Albas 325 Rhizoma Gastrodiaes 325 Sanguis Draxonis 180
Carapax Trionycis 450 Radix Aconiti Lateralis Preparatas 160 Radix Angelicae Sinensis 360 Radix Salviae Miltiorrhizaes 360
Flos Carthami 90 Pheretimas 160 Carapax et Plastrum Testudiniss 450 Herba Asaris 160
The Rhizoma Pinelliae 180 Rhizoma Et Radix Notopterygiis 270 Rhizoma Curculiginises 270 Ramulus Uncariae Cum Uncis 270
Radix Glycyrrhizae 180 Radix Asparagis 180 Fructus Jujubaes 90
Embodiment 2
Take by weighing raw material by following weight proportion
Radix Notoginseng 220 Radixs Astragali 330 Rhizoma Corydalis 880 Lignum Aquilariae Resinatum 440
Radix Puerariae 330 Rhizoma Atractylodis Macrocephalaes 330 Pericarpium Papaveriss 165 Radix Ginsengs 220
The Cortex Eucommiae 330 Bombyx Batryticatus 200 Flos Daturaes 30 Radix Morindae Officinaliss 200
Rhizoma Chuanxiong 395 Radix Curcumaes 395 Poria cum Radix Pinis 200 Radix Trichosanthis 200
Succinum 110 Semen Strychni 30 Olibanums 440 Myrrhas 440
Radix Dipsaci 440 Radix Paeoniae Albas 395 Rhizoma Gastrodiaes 395 Sanguis Draxonis 220
Carapax Trionycis 550 Radix Aconiti Lateralis Preparatas 200 Radix Angelicae Sinensis 440 Radix Salviae Miltiorrhizaes 440
Flos Carthami 110 Pheretimas 200 Carapax et Plastrum Testudiniss 550 Herba Asaris 200
The Rhizoma Pinelliae 220 Rhizoma Et Radix Notopterygiis 330 Rhizoma Curculiginises 330 Ramulus Uncariae Cum Uncis 330
Radix Glycyrrhizae 220 Radix Asparagis 220 Fructus Jujubaes 110
Embodiment 3
Take by weighing raw material by following weight proportion
Radix Notoginseng 200 Radixs Astragali 300 Rhizoma Corydalis 800 Lignum Aquilariae Resinatum 400
Radix Puerariae 300 Rhizoma Atractylodis Macrocephalaes 300 Pericarpium Papaveriss 150 Radix Ginsengs 200
The Cortex Eucommiae 300 Bombyx Batryticatus 180 Flos Daturaes 30 Radix Morindae Officinaliss 180
Rhizoma Chuanxiong 360 Radix Curcumaes 360 Poria cum Radix Pinis 180 Radix Trichosanthis 180
Succinum 100 Semen Strychni 30 Olibanums 400 Myrrhas 400
Radix Dipsaci 400 Radix Paeoniae Albas 360 Rhizoma Gastrodiaes 360 Sanguis Draxonis 200
Carapax Trionycis 500 Radix Aconiti Lateralis Preparatas 180 Radix Angelicae Sinensis 400 Radix Salviae Miltiorrhizaes 400
Flos Carthami 100 Pheretimas 180 Carapax et Plastrum Testudiniss 500 Herba Asaris 180
The Rhizoma Pinelliae 200 Rhizoma Et Radix Notopterygiis 300 Rhizoma Curculiginises 300 Ramulus Uncariae Cum Uncis 300
Radix Glycyrrhizae 200 Radix Asparagis 200 Fructus Jujubaes 100
The above-mentioned raw materials medicine all prepares by Pharmacopoeia of People's Republic of China nineteen ninety-five version.
The preparation method of the pill of the described weight proportion of the foregoing description is as follows:
1, the directly pulverizing of succinum, Carapax et Plastrum Testudinis, Carapax Trionycis, Olibanum, Myrrha, Sanguis Draxonis in the above-mentioned raw materials being processed the back pulverizes, after processing, Bombyx Batryticatus, Pheretima, Semen Strychni, Radix Aconiti Lateralis Preparata, the Rhizoma Pinelliae grind into powder, Lignum Aquilariae Resinatum is adopted the rasion barreling, profits such as Rhizoma Gastrodiae, Radix Angelicae Sinensis, Radix Asparagi, Radix Ginseng, Radix Salviae Miltiorrhizae, the Radix Astragali are cut after drying and are pulverized, and cut off after Herba Asari, Rhizoma Curculiginis, Ramulus Uncariae Cum Uncis, Flos Carthami, Rhizoma Et Radix Notopterygii, the Radix Glycyrrhizae drying and pulverize;
2, the Semen Strychni after will pulverizing, the Rhizoma Pinelliae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, succinum are crossed 100 mesh sieves respectively, and all the other 34 flavor crude drug are crossed 40-60 mesh sieves earlier, after 80 mesh sieves, mixing then;
3, Mel being heated to boiling and color joins in the medicated powder in 100% ratio of mixed uniform crude drug weight when being brownish red, again the 30-50% ratio of distilled water in raw material weight also added in the medicated powder, with conventional method plant equipment mixing, rubbing, general ball;
4, carry out indexs such as moisture content, outward appearance, disintegrate and content of microorganisms after the pill molding by first one of Pharmacopoeia of People's Republic of China nineteen ninety-five version and detect, up to specification after, with the Cinnabaris coating, mechanical polishing, every Weight control is at 0.05g, it is standby to bottle.
This invention medicine is an oral administration pills, and early stage, clinical using dosage was each 6-12g, should take after mixing it with water with brown sugar water under physician guidance every day 3-6 time at every turn, fasting Semen phaseoli radiati in taking medicine, prohibits the water of drinking tea, and anemia of pregnant woman and bleeder are forbidden.
Claims (8)
1. Narcotic Chinese medicine thing is characterized in that it is the medicament of being made by the following weight proportion raw material:
Radix Notoginseng 180-220 Radix Astragali 270-330 Rhizoma Corydalis 720-880 Lignum Aquilariae Resinatum 360-440
Radix Puerariae 270-330 Rhizoma Atractylodis Macrocephalae 270-330 Pericarpium Papaveris 135-165 Radix Ginseng 180-220
Cortex Eucommiae 270-330 Bombyx Batryticatus 160-200 Flos Daturae 27-30 Radix Morindae Officinalis 160-200
Rhizoma Chuanxiong 325-395 Radix Curcumae Poria cum Radix Pini 325-395 160-200 Radix Trichosanthis 160-200
Succinum 90-110 Semen Strychni 27-30 Olibanum 360-440 Myrrha 360-440
Radix Dipsaci 360-440 Radix Paeoniae Alba 325-395 Rhizoma Gastrodiae 325-395 Sanguis Draxonis 180-220
Carapax Trionycis 450-550 Radix Aconiti Lateralis Preparata 160-200 Radix Angelicae Sinensis 360-440 Radix Salviae Miltiorrhizae 360-440
Flos Carthami 90-110 Pheretima 160-200 Carapax et Plastrum Testudinis 450-550 Herba Asari 160-200
Rhizoma Pinelliae 180-220 Rhizoma Et Radix Notopterygii 270-330 Rhizoma Curculiginis 270-330 Ramulus Uncariae Cum Uncis 270-330
Radix Glycyrrhizae 180-220 Radix Asparagi 180-220 Fructus Jujubae 90-110.
2. a kind of Narcotic Chinese medicine thing according to claim 1, it is characterized in that: wherein the weight proportion of each raw material is:
Radix Notoginseng 190-210 Radix Astragali 280-330 Rhizoma Corydalis 730-870 Lignum Aquilariae Resinatum 370-420
Radix Puerariae 280-320 Rhizoma Atractylodis Macrocephalae 280-320 Pericarpium Papaveris 140-160 Radix Ginseng 190-210
Cortex Eucommiae 280-320 Bombyx Batryticatus 170-190 Flos Daturae 28-30 Radix Morindae Officinalis 170-190
Rhizoma Chuanxiong 330-390 Radix Curcumae Poria cum Radix Pini 330-390 170-190 Radix Trichosanthis 170-190
Succinum 90-100 Semen Strychni 28-30 Olibanum 370-430 Myrrha 370-430
Radix Dipsaci 370-430 Radix Paeoniae Alba 330-390 Rhizoma Gastrodiae 330-390 Sanguis Draxonis 190-210
Carapax Trionycis 460-540 Radix Aconiti Lateralis Preparata 170-190 Radix Angelicae Sinensis 370-430 Radix Salviae Miltiorrhizae 370-430
Flos Carthami 100-110 Pheretima 170-190 Carapax et Plastrum Testudinis 460-540 Herba Asari 170-190
Rhizoma Pinelliae 190-210 Rhizoma Et Radix Notopterygii 280-320 Rhizoma Curculiginis 280-320 Ramulus Uncariae Cum Uncis 280-320
The big winter 190-210 of Radix Glycyrrhizae 190-210 Fructus Jujubae 90-100.
3. a kind of Narcotic Chinese medicine thing according to claim 1, it is characterized in that: wherein the weight proportion of each raw material is:
Radix Notoginseng 200 Radixs Astragali 300 Rhizoma Corydalis 800 Lignum Aquilariae Resinatum 400
Radix Puerariae 300 Rhizoma Atractylodis Macrocephalaes 300 Pericarpium Papaveriss 150 Radix Ginsengs 200
The Cortex Eucommiae 300 Bombyx Batryticatus 180 Flos Daturaes 30 Radix Morindae Officinaliss 180
Rhizoma Chuanxiong 360 Radix Curcumaes 360 Poria cum Radix Pinis 180 Radix Trichosanthis 180
Succinum 100 Semen Strychni 30 Olibanums 400 Myrrhas 400
Radix Dipsaci 400 Radix Paeoniae Albas 360 Rhizoma Gastrodiaes 360 Sanguis Draxonis 200
Carapax Trionycis 500 Radix Aconiti Lateralis Preparatas 180 Radix Angelicae Sinensis 400 Radix Salviae Miltiorrhizaes 400
Flos Carthami 100 Pheretimas 180 Carapax et Plastrum Testudiniss 500 Herba Asaris 180
The Rhizoma Pinelliae 200 Rhizoma Et Radix Notopterygiis 300 Rhizoma Curculiginises 300 Ramulus Uncariae Cum Uncis 300
Radix Glycyrrhizae 200 Radix Asparagis 200 Fructus Jujubaes 100.
4. a kind of Narcotic Chinese medicine thing according to claim 1 is characterized in that described medicament is a pill.
5. the preparation method of a kind of Narcotic Chinese medicine thing according to claim 4 is characterized in that: after described raw material classification is pulverized, through sieving, mixing, add Mel and distilled water mixing, rubbing then, make pill.
6. the preparation method of a kind of Narcotic Chinese medicine thing according to claim 5, it is characterized in that: succinum, Carapax et Plastrum Testudinis, Carapax Trionycis are directly pulverized in the described raw material, Olibanum, Myrrha, Sanguis Draxonis are processed the back and are pulverized, after processing, Bombyx Batryticatus, Pheretima, Semen Strychni, Radix Aconiti Lateralis Preparata, the Rhizoma Pinelliae grind into powder, Lignum Aquilariae Resinatum is adopted the rasion barreling, profits such as Rhizoma Gastrodiae, Radix Angelicae Sinensis, Radix Asparagi, Radix Ginseng, Radix Salviae Miltiorrhizae, the Radix Astragali are cut after drying and are pulverized, and cut off after Herba Asari, Rhizoma Curculiginis, Ramulus Uncariae Cum Uncis, Flos Carthami, Rhizoma Et Radix Notopterygii, the Radix Glycyrrhizae drying and pulverize.
7. the preparation method of a kind of Narcotic Chinese medicine thing according to claim 5, it is characterized in that: cross 100 mesh sieves respectively after Semen Strychni, the Rhizoma Pinelliae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, succinum are pulverized in the described raw material, residue 34 flavor raw materials are crossed the 40-60 mesh sieve earlier, and behind 80 mesh sieves, described 39 flavor raw materials mix.
8. the preparation method of a kind of Narcotic Chinese medicine thing according to claim 5 is characterized in that: described Mel be heated to boiling and color when being brownish red 100% ratio in raw material weight add, distilled water is by the 30%-50% ratio adding of raw material weight.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB031282261A CN100394976C (en) | 2003-06-27 | 2003-06-27 | Chinese medicine for withdrawal of drug dependence |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB031282261A CN100394976C (en) | 2003-06-27 | 2003-06-27 | Chinese medicine for withdrawal of drug dependence |
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| Publication Number | Publication Date |
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| CN1471954A CN1471954A (en) | 2004-02-04 |
| CN100394976C true CN100394976C (en) | 2008-06-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB031282261A Expired - Fee Related CN100394976C (en) | 2003-06-27 | 2003-06-27 | Chinese medicine for withdrawal of drug dependence |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102861289A (en) * | 2012-09-10 | 2013-01-09 | 熊治成 | Chinese medicinal drug addiction stopping and three-hyper lowering capsule |
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|---|---|---|---|---|
| CN102406780B (en) * | 2011-11-22 | 2013-07-31 | 伍玉光 | Traditional Chinese medicine composition used for drug abstinence |
| CN102973722B (en) * | 2012-11-28 | 2014-12-17 | 赵作君 | Novel anesthetic |
| CN103316285B (en) * | 2013-05-15 | 2014-08-13 | 苏振侥 | Traditional Chinese medicine for drug rehabilitation |
| CN106860823A (en) * | 2017-03-03 | 2017-06-20 | 王恒飞 | A kind of medicine given up to benzodiazepine habituation and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1163132A (en) * | 1996-08-22 | 1997-10-29 | 陕西森源药业有限公司 | Oral liquor for giving up drug |
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2003
- 2003-06-27 CN CNB031282261A patent/CN100394976C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1163132A (en) * | 1996-08-22 | 1997-10-29 | 陕西森源药业有限公司 | Oral liquor for giving up drug |
Non-Patent Citations (2)
| Title |
|---|
| 乌拉地尔对吗啡依赖新生大鼠肾上腺皮质组织化学影响. 李艳萍，张桂娥，武俊芳.实用儿科临床杂志，第14卷第5期. 1999 |
| 乌拉地尔对吗啡依赖新生大鼠肾上腺皮质组织化学影响. 李艳萍，张桂娥，武俊芳.实用儿科临床杂志，第14卷第5期. 1999 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102861289A (en) * | 2012-09-10 | 2013-01-09 | 熊治成 | Chinese medicinal drug addiction stopping and three-hyper lowering capsule |
| CN102861289B (en) * | 2012-09-10 | 2014-07-16 | 熊治成 | Chinese medicinal drug addiction stopping and three-hyper lowering capsule |
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| Publication number | Publication date |
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| CN1471954A (en) | 2004-02-04 |
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