CN102861289B - Chinese medicinal drug addiction stopping and three-hyper lowering capsule - Google Patents

Abstract

The invention discloses a Chinese medicinal drug addiction stopping and three-hyper lowering capsule, which is prepared by cleaning, drying, smashing, uniformly mixing and loading 39 types of Chinese medicines such as pseudo-ginseng root, astragalus, corydalis tuber, Chinese eaglewood, and ginseng into a capsule. The Chinese medicinal drug addiction stopping and three-hyper lowering capsule has the advantages of stable curative effect, short treatment course, small toxic and side effects and low relapse rate. The capsule also has an immunity enhancing function on a patient suffering from 'three-hyper (hypertension, hyperlipemia and hyperglycemia)' in cardiovascular system diseases, and a rehabilitation effect is achieved.

Description

Three-hypers capsule falls in Chinese medicinal drug withdrawal

Technical field

The present invention relates to a kind of anti-additive medicament that belongs to Chinese medicine preparation, especially a kind of when being not only used for the treatment of opiate addiction but also can strengthen immune function of human body, promote the Chinese medicinal drug withdrawal of cardiovascular and cerebrovascular disease rehabilitation to fall three-hypers capsule.

Background technology

In recent years, the junkie ratio of sucking opium drug addiction increases year by year, become serious social problem, drugs become the able-bodied killer of harm humans, how to make junkie rehabilitate addicts, toxin is in vivo gathered in removing, reaches from physiology and the psychological thoroughly object for the treatment of narcotic addiction, has become the target that medical personnel pursues with all strength.

Conventional treating narcotic addiction method is divided into gives up taking addictive drugs by force and the large class of medicine treating narcotic addiction two, give up taking addictive drugs by force without medicine, carry out the stage by force, needs of patients strong will, bear painful large, generally be only applicable to the patient that the time of sucking is short, the amount of sucking is little, drug addiction is little and have a strong constitution, the scope of application is little, effect is not good enough; And medicine treating narcotic addiction is divided into substitution method, decrement method, hibernation method.Substitution method is to adopt the alternative drugs of Western medicine that the addiction such as " methadone ", " dihydroetorphine hydrochlorate ", " buprenorphine ", " dolantin " are little to treat, although can rehabilitate addicts to a certain extent, patient easily produces dependency to alternative medicine; Decrement method is to adopt the method that reduces gradually the drugs amount of sucking, and patient is progressively rehabilitated addicts, but the method cycle is long, therapeutic effect is undesirable; Hibernation method is to adopt powerful tranquilizer to make patient in hibernation-like state, prevent drug addiction outbreak, lower the dependence of patient to drugs, but the method can cause damage to patient's nervous system, or even irreversible permanent damage.In sum, above-mentioned conventional treating narcotic addiction method all exists curative effect unstable, and treatment cycle length, gastrointestinal tract and neural side effect are large, the drawback thorough, relapse rate is high of rehabilitating addicts.

At present, use detoxification by Chinese medicine to cause the domestic and international personage's of the world of medicine extensive attention, and make some progress, formed unique traditional Chinese medical science science, method, prescription, drugs serial therapy scheme.Yet syndrome conclusion, Therapeutic Principle and medicine that the whole world is given up after to drug addiction are selected, still lack arrangement and the research of system.The tcm syndrome of opioid drug dependence syndrome is the same with the disease of other traditional Chinese medical science disease, the feature equally with complexity, multiformity, polytropy, therefore the Chinese government has also dropped into a large amount of manpower and materials encouraging to utilize traditional Chinese medicine method to inquire into aspect new treating narcotic addiction research.

China Patent Publication No. is that the patent of invention of CN100394976C discloses a kind of Chinese medicine for giving-up drugging, the 39 taste Chinese herbal medicine such as Radix Notoginseng, the Radix Astragali, Rhizoma Corydalis, Lignum Aquilariae Resinatum, Radix Ginseng are made to pill after pulverizing, sieve, mixing, although there is certain drug abstinence, but exist, abnormal smells from the patient is difficult to accept, taking dose is large, patient's resentment is strong, for the three-hypers patient (hypertension, hyperlipidemia and hyperglycemia) who catches drug addiction, when taking this medicine, also need to take the shortcomings such as other drug.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of Chinese medicinal drug withdrawal and falls three-hypers capsule, have no side effect, stable curative effect, short treating period, side effect are little, human body and psychological withdrawal is thorough, relapse rate is low, safe and reliable, with low cost, especially can also nurse one's health the health of junkie, can alleviate hypotension and cerebral anoxia symptom, reduce " three-hypers disease ", to suffering from the patient of cardiovascular and cerebrovascular disease, diabetes, hypertension, there is equally treatment and attack effect, expanded the disease kind crowd for the treatment of and the category of disease.

For solving the problems of the technologies described above, the technical solution adopted in the present invention is: three-hypers capsule falls in a kind of Chinese medicinal drug withdrawal, the medicament that it is made by the raw material of following weight parts proportioning:

The Radix Astragali 240～300 Rhizoma Gastrodiae 300～350 Rhizoma Corydalis 700～750 Lignum Aquilariae Resinatum 320～400

Radix Puerariae 240～300 Radix Trichosanthis 140～180 Cortex Eucommiae 240～300 Bombyx Batryticatus 140～180

Rhizoma Chuanxiong 300～350 Radix Curcumae 300～350 Poria cum Radix Pini's 140～180 succinums 65～115

Semen Strychni 27～30 Rhizoma Curculiginis 240～300 Radix Dipsaci 320～400 Radix Paeoniae Albas 300～350

Sanguis Draxonis 150～210 Radix Notoginseng 150～210 Flos Daturae 27～30 Radix Angelicae Sinensis 320～400

Radix Aconiti Lateralis Preparata 140～180 Radix Morindae Officinalis 140～180 Radix Salviae Miltiorrhizae 320～400 Flos Carthamis 65～115

Pheretima 140～180 Herba Asari 140～180 Pericarpium Papaveris 100～170 Rhizoma Pinelliaes 150～210

Rhizoma Et Radix Notopterygii 240～300 Ramulus Uncariae Cum Uncis 240～300 Radix Asparagi 150～210 Radix Ginsengs 150～210

The Rhizoma Atractylodis Macrocephalae 240～300 Fructus Jujubae 65～115 Folium Pini 695～745 Radix Rhodiolaes 320～400

Hirudo 240～300 Cordyceps 140～180 Herb Gynostemmae Pentaphylli 240～300.

Wherein, preferred weight part proportioning of each crude drug is:

The Radix Astragali 250～290 Rhizoma Gastrodiae 310～340 Rhizoma Corydalis 710～740 Lignum Aquilariae Resinatum 330～390

Radix Puerariae 250～290 Radix Trichosanthis 150～170 Cortex Eucommiae 250～290 Bombyx Batryticatus 150～170

Rhizoma Chuanxiong 310～340 Radix Curcumae 310～340 Poria cum Radix Pini's 150～170 succinums 75～105

Semen Strychni 27～29 Rhizoma Curculiginis 250～290 Radix Dipsaci 330～390 Radix Paeoniae Albas 310～340

Sanguis Draxonis 160～200 Radix Notoginseng 160～200 Flos Daturae 27～29 Radix Angelicae Sinensis 330～390

Radix Aconiti Lateralis Preparata 150～170 Radix Morindae Officinalis 150～170 Radix Salviae Miltiorrhizae 330～390 Flos Carthamis 75～105

Pheretima 150～170 Herba Asari 150～170 Pericarpium Papaveris 110～160 Rhizoma Pinelliaes 160～200

Rhizoma Et Radix Notopterygii 250～290 Ramulus Uncariae Cum Uncis 250～290 Radix Asparagi 160～200 Radix Ginsengs 160～200

The Rhizoma Atractylodis Macrocephalae 250～290 Fructus Jujubae 75～105 Folium Pini 705～735 Radix Rhodiolaes 330～390

Hirudo 250～290 Cordyceps 150～170 Herb Gynostemmae Pentaphylli 250～290.

Wherein optimum weight part proportioning of each crude drug is:

The Radix Astragali 270 Rhizoma Gastrodiae 325 Rhizoma Corydalis 720 Lignum Aquilariae Resinatum 360

Radix Puerariae 270 Radix Trichosanthis 160 Cortex Eucommiae 270 Bombyx Batryticatus 160

Rhizoma Chuanxiong 325 Radix Curcumae 325 Poria cum Radix Pini's 160 succinums 90

Semen Strychni 27 Rhizoma Curculiginis 270 Radix Dipsaci 360 Radix Paeoniae Albas 325

Sanguis Draxonis 180 Radix Notoginseng 180 Flos Daturae 27 Radix Angelicae Sinensis 360

Radix Aconiti Lateralis Preparata 160 Radix Morindae Officinalis 160 Radix Salviae Miltiorrhizae 360 Flos Carthamis 90

Pheretima 160 Herba Asari 160 Pericarpium Papaveris 135 Rhizoma Pinelliaes 180

Rhizoma Et Radix Notopterygii 270 Ramulus Uncariae Cum Uncis 270 Radix Asparagi 180 Radix Ginsengs 180

The Rhizoma Atractylodis Macrocephalae 270 Fructus Jujubae 90 Folium Pini 720 Radix Rhodiolaes 360

Hirudo 270 Cordyceps 160 Herb Gynostemmae Pentaphylli 270.

Preparation method: the preparation method of capsule preparations is got the raw materials ready above medicine by above-mentioned weight portion proportioning routinely; Through classification cleaning, oven dry, pulverizing, mix homogeneously, in incapsulating, the medicated powder of each capsule 0.5g dosage.

Formula of the present invention is understanding and the Therapeutic Principle to opium drug addiction mechanism based on Chinese medicine and pharmacy, and a patent of invention < < Chinese medicine for giving-up drugging > > (China Patent Publication No. CN100394976C) thinks after practice analysis for clinical more than ten years, detoxification treatment to opiate addiction, the multiple diseases such as Ying Congfeng, expectorant, poison, the stasis of blood, void are come comprehensively dialectical, it is main adopting righting, reaches eliminating evil object.

Formula of the present invention is on the basic side's of a patent of invention < < Chinese medicine for giving-up drugging > > (China Patent Publication No. CN100394976C) basis, reasonable adjustment and plus-minus have been carried out, the person's that takes into account consume illegal drugs the amount of sucking is how many, course of disease length, disease weight deficiency and excess screen in various degree analysis, formulate the principles of formulating prescriptions of drug addiction treatment, deduct Carapax Trionycis, Carapax et Plastrum Testudinis, Myrrha, Olibanum and Radix Glycyrrhizae five tastes medicine, add Folium Pini, Radix Rhodiolae, Hirudo, Cordyceps and Herb Gynostemmae Pentaphylli five tastes medicine, form new Chinese medicine preparation.

The prescription function of the present invention formula is: heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, the kidney warming consolidate, ease pain calm the nerves, activating spleen and strengthening stomach, strengthening vital QI to eliminate pathogenic factors.

Wherein, Radix Notoginseng is containing arasaponin alkaloid, blood circulation promoting and blood stasis dispelling, analgesic hemostatic, mainly curing cardiovascular systemic disease and all kinds of pain, angor, hemorrhage damage etc.; Radix Ginseng is containing the rare class Saponin of triterpene, from ginseng glycoside, RB1, fruit acid, saccharide, and strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promoting the production of body fluid and inducing sedation of the mind, cure mainly collapse, the deficiency of vital energy etc., excited N maincenter, shock; The Radix Astragali is defended consolidating superficial resistance, promoting pus discharge and tissue regeneration strengthening, excited N maincenter, is improved resistance against diseases containing saccharide, choline, folic acid, several aminoacid, B～sitosterol etc., tonifying Qi and lifting yang, benefit, have cardiotonic, blood vessel dilating, reduce blood pressure, improve skin microcirculation, the liver protecting liver glycogen reduces, a little less than curing mainly deficiency of vital energy and physically weak, blood deficiency gas; The Rhizoma Atractylodis Macrocephalae is containing volatile oil, there is significantly lasting diuresis, and can promote the particularly discharge of sodium of electrolyte, blood sugar lowering, the liver protecting, invigorating the spleen and replenishing QI, dampness diuretic, strengthening superficial resistance to stop perspiration, cure mainly the disease of diet minimizing due to deficiency of spleen-QI and stomach-QI, dysfunction of the spleen in transportation and transformation, fatigue and weakness and middle burnt yang deficiency; Rhizoma Corydalis is containing 15 kinds of alkaloids, and Rhizoma Corydalis second element, ugly element and first element have that obvious analgesia and spasmolysis, relaxed muscle and town are told, invigorated blood circulation, promoting the circulation of QI to relieve pain, do not have toxicity, cures mainly various pain, can sleep peacefully by antalgic and sedative; Lignum Aquilariae Resinatum is containing benzylacetone and to methoxybenzyl benzylacetone, the rare alcohols of terpene and cinnamic acid, promoting the circulation of QI to relieve pain, wet in cold expelling, lowering the adverse QI to relieve asthma, cure mainly that breast gastral cavity is swollen has a pain, suffers from abdominal pain; Radix Puerariae is containing flavonoid and starch, there are antipyretic expelling pathogenic factors from muscles, blood sugar lowering, hypotensive activity, effectively improve cerebral circulation and circulation around, to intravenous injection acute myocardial ischemia that pituitrin causes, reaction has protective effect, expelling pathogenic factors from muscles, yang invigorating, promote the production of body fluid, cure mainly the diseases such as phase stiffback pain, diabetes and headache, dizziness, numb limbs and tense tendons; Folium Pini contains the compositions such as volatile oil, flavonoid, resin, cellulose, lignin, chlorophyll, carotene, vitamin, trace element, removing toxic substances dehumidifying, and removing obstruction in the collateral to relieve pain, cures mainly the retardance of addict's tobacco poisoning, blockage of main and collateral channels, the card of general aching; In Radix Rhodiolae, contain 35 kinds of trace element, 18 seed amino acids, vitamin A. D. E and activity of fighting against senium superoxides, energy antitumor, protection cardiovascular and cerebrovascular vessel, defying age, radioprotective and cerebral anoxia, with the heal heresy of addiction of righting, nerve system of human body, blood circulation system, metabolic system, hormonal system etc. are had to good whole opsonic action; Hirudo contains hirudin, is the most effective known natural anticoagulant, and its effect is better than heparin, has anticoagulation, thrombolytic effect, and dredging collateral removing blood stasis, removing toxic substances pain relieving, recover cranial nerve function; Cordyceps contains cordycepic acid, vitamin B12, Ergota lipidol, hexose alcohol, multiple alkaloid etc., and property is sweet, Wen Ping, nontoxic, and tonifying the lung kidney two feeling pulse are empty, repose and get rid of illness, and primordial QI reinforcing reinforcing is to get rid of evils treating narcotic addiction; Herb Gynostemmae Pentaphylli contains sterol, sugar part, pigment and more than 50 kind of Saponin, can reduce hypertension, hyperlipidemia, hyperglycemia, the anti-cardiovascular and cerebrovascular disease of antitoxin addiction.

Clinical drug of the present invention is used result to show there is following advantage:

1, to select natural edible Chinese herbal medicine be raw material in the present invention, each component meets Pharmacopoeia of People's Republic of China version regulation in 2010, utilize the comprehensive efficacy of a drug effect treatment opiate addiction patient of all kinds of Chinese medicines, toxic and side effects is little, to cardiovascular system, central nervous system, internal organs, can not cause permanent damage.

2, medicine of the present invention can replace expensive Western medicine, can thoroughly give up patient's drug addiction, and can not cause the dependence to medicine of the present invention, and from physiology with rehabilitate addicts psychologically, relapse rate is low, and treatment cost is cheap, therapeutic process no pain.By perspiration, urine or stool, drugs are got rid of external, the reaction that has no side effect, junkie is waking state in therapeutic process, enjoys, sleeps surely, light detoxification.

3, with a patent of invention < < Chinese medicine for giving-up drugging > > (China Patent Publication No. CN100394976C), compare, the dose of medicine of the present invention reduces, the dosage of 1～3 day is reduced to 9 grams/times by original 12 grams/times, every TDD drops to 50～60 grams/day by original 60～80 grams/day, and the dosage form of medicament is become to capsule from original pill, overcome original pill abnormal smells from the patient and be difficult to the shortcoming of accepting, greatly reduce junkie and take resentment and the mental burden of anti-additive medicament.

4, with a patent of invention < < Chinese medicine for giving-up drugging > > (China Patent Publication No. CN100394976C), compare, prescription Folium Pini after medicine of the present invention is adjusted, Radix Rhodiolae, Hirudo, Cordyceps and Herb Gynostemmae Pentaphylli five tastes medicine have been replaced the Carapax Trionycis in original prescription, Carapax et Plastrum Testudinis, Myrrha, Olibanum and Radix Glycyrrhizae, in prescription function, and on vicissitudinous basis, obviously do not promoted therapeutic effect, strengthened the anti-immunity of medicine, the concentration of detoxifying in the blood persistent period is longer, the time of relief of symptoms extended to 7～8 hours by original 3～5 hours, effectively extended the effect phase of drug addiction treatment, improved widely the confidence of patient's treating narcotic addiction of consume illegal drugs.

5, with a patent of invention < < Chinese medicine for giving-up drugging > > (China Patent Publication No. CN100394976C), compare, side effect and contraindication reduce, a < < Chinese medicine for giving-up drugging > > (China Patent Publication No. CN100394976C) need prohibit at period in a medicine the water of drinking tea, and medicine period in a medicine of the present invention needn't be prohibited the water of drinking tea, untoward reaction is slight.

6, with a patent of invention < < Chinese medicine for giving-up drugging > > (China Patent Publication No. CN100394976C), compare, medicine of the present invention not only reaches and has maintained former prescription drug abstinence, due to the Folium Pini newly increasing, Radix Rhodiolae, Hirudo, Cordyceps and Herb Gynostemmae Pentaphylli five tastes medicine also have antitumor, protection cardiovascular and cerebrovascular vessel, defying age, radiation-resisting functional, and can also alleviate hypotension and cerebral anoxia symptom, reduce " three-hypers disease ", to suffering from cardiovascular and cerebrovascular disease, diabetes, the patient of hypertension has equally treatment and attacks effect, the disease kind crowd for the treatment of and the category of disease have been expanded, for Changes of Patients With Cerebrovascular Diseases, for in radiation or the crowd of anoxia working environment, diabetes patient (hypertension or hyperlipidemia patient) has brought Gospel.

For showing the therapeutic effect of medicine of the present invention to opiate addiction, to 48 examples, use the opiate addiction patient of this medicine to carry out clinical follow-up observation, be 15 days the course for the treatment of.

The instructions of taking of medicine:

1st～3 days, 9 grams/times, every 3～4 hours/time, 50～60 grams of every TDDs;

4th～10 days, 6 grams/times, every 6～8 hours/time, 20～30 grams of every TDDs;

11st～15 days, 3-6 gram/times, every 8 hours/time, 10～20 grams of every TDDs;

During treatment, avoid the pungent irritable food that waits.

Onset standard and the timing of medicine of the present invention aspect rehabilitating addicts: above experimenter all starts to take medicine at the main manifestations outbreak rear of withdrawal symptom, as gape, perspiration, fluid are shed tears, shivered with cold, newly machine, worm climb formication etc. for spasm, agitation, treat that above transference cure is as the criterion, computation time.

The clinical effective standard of rehabilitating addicts: after medication, withdrawal symptom disappears, does not occur repeatedly after rationally subtracting medicine.

The clinical cure standard of rehabilitating addicts:

1, drug withdrawal is after 1 day, and naloxone 0.4～0.8mg intramuscular injection went out without withdrawal symptom in 1 hour

Existing.

2, Urine drug abuse test (-).

3, body No Poison demand and dependence.

4, spirit is emotionally stable, and diet sleep is normal, and muscle power has certain recovery.

Clinical follow-up observation result is as shown in table 1:

Table 1 is used the curative effect (n, %) of medicine of the present invention

Disease	Number of cases	Cure	Effectively	Invalid	Effective percentage
						Suck heroin	7	5（71.43）	2（28.57）	0（0.00）	100
Heroin merges sucks methamphetamine hydrochloride	4	2（50.00）	2（50.00）	0（0.00）	100
						Heroin merges sucks fiber crops Gu	7	5（71.43）	1（14.29）	1（14.29）	85.72
Heroin merges sucks head-shaking pill	4	3（75.00）	1（25.00）	0（0.00）	100
						Heroin merges sucks KET	2	2（100.00）	0（0.00）	0（0.00）	100
Add up to	24	17（70.83）	6（25.00）	1（4.17）	95.83

Medicine of the present invention detoxification treatment to opiate addiction simultaneously " cautiously grasping pathogenesis, in detail distinguish deficiency and excess, the reasonable side of sending " taken into account enhancing immune function of human body.As promoting blood circulation and detoxication, numbness relieving and pain relieving have been taken into account peace and the five internal organs; When rehabilitating addicts, taken into account protection cardiovascular and cerebrovascular vessel, protected cerebral anoxia, promoted cranial nerve function recovery, hindered the further infringement of the toxin such as opiates to cardiovascular and cerebrovascular vessel.Effectively reduce " three-hypers disease " (hypertension, hyperlipidemia, hyperglycemia).

Therapeutic effect of the present invention can also show from the therapeutic process of following model case:

Model case 1, Wang, man, 33 years old, consume illegal drugs (be mainly heroin, fiber crops ancient) 8 years, every 3 days, suck once symptom: the fidgety irritability of temper, introverted, fear to be monitored own action by people, thinking that someone will kill oneself, is the mental disorder due to consume illegal drugs after diagnosing.Take medicine of the present invention and within 7 days, initiatively look for afterwards people to heartly talk, after 14 days, temper recovers normal, no longer thinks that someone will kill oneself.Further consultation after three months, and give psychological counseling, current every health and psychological indicator performance are good, and represent no longer to take drugs from now on.

Model case 2: Liu, man, 35 years old, consume illegal drugs (intramuscular injection heroin, maximum every day 7 grams) 8 years, symptom: health is become thin, complexion is gloomy, and appetite obviously goes down, and only eats a meal every day, and abdominal distention is felt sick, time feel right flank pain, sleepy weak, shortness of breath and tired spirit, yellow urine is short; Signs: expression is painful, One's eyesight is restrained, cardiopulmonary no abnormality seen, abdomen is soft, under liver right flank, can touch 1.5cm, and matter is soft, touches a tender spot obviously, percussion tenderness over hepatic region; Lab testing: hepatitis b surface antigen positive, alanine aminotransferase 140u, urine morphine is tested the positive surely.Through taking this medicine, patient's sensory symptoms alleviates day by day, and spirit also takes a turn for the better to some extent, and sleepy weak symptom is obviously improved, and diet increases, and urine is clear by xanthochromia; Take after 7 days and check alanine aminotransferase 80u, rear continuation after treatment, sees propylhomoserin aminotransferase 30 after 13 days, and patient's drug addiction is removed, and subjective symptoms disappears, have rosy cheeks, and brisk condition of mind.Urine morphine qualitative test is negative.Therefore, medicine of the present invention can also kill hepatitis virus, and the toxicity damage of relieving liver parenchyma can impel liver cell regeneration, and can improve liver blood circulation and liver function.

Model case 3: Xu certain, man, 35 years old, consume illegal drugs (heroin) 10 years, repeatedly treating narcotic addiction does not all relapse again because heart addiction eliminates, symptom: cold extremities, foot fiber crops.Look into: chronic facies, two lung audible and dry rales, 102 beats/min of hearts rate, epigastrium has tenderness, and liver, spleen do not touch, alanine aminotransferase 140u, blood pressure 148/112mmHg, blood glucose is not looked into, and upper limb is shown in that pin trace is innumerable, and some veins are streak hard thing.Skin temperature reduces, and toenail is withered matt, and fine hair comes off.Electrocardioscopy finds that T ripple changes, determination of immunoglobulin: IgM2460/L, and blood flow becomes inspection: packed cell volume: 60%, blood plasma viscosity all increases.After checking, consider that its heart, lung and liver function are all undesired, matter deviation, took medicine of the present invention after 10 days, spirit is clearly better, sleepy weak symptom is obviously improved, and diet increases, and urine is clear by xanthochromia, check alanine aminotransferase drops to 80u, two lung dry rales disappear, and post-prandial glycemia drops to 9, and controlling of blood pressure is at blood pressure 130/92mmHg, medicine of the present invention obviously impels liver cell regeneration in treating narcotic addiction, and has improved liver blood circulation and liver function.Take after the 15th day and check alanine aminotransferase 42u, liver function transfers to normally substantially.Patient has rosy cheeks, and the morphine qualitative test that has urine examined is negative, and 'Duyinxiao ' removes, and leave hospital next day.

Model case 4: Lee, female, 29 years old, consume illegal drugs (heroin, " KET ") 3 years, symptom:

Drug abuse resistance declines, and becomes thin, and expression is frightened, often occurs the abdominal distention that has a stomach-ache.Take medicine of the present invention after 7 days, tired symptom is obviously improved, and diet increases, the abdominal distention that has a stomach-ache transference cure, and urine is normal, drug addiction etc., and subjective symptoms disappears substantially, and the morphine qualitative test that has urine examined for the 12nd day is cloudy.

Model case 5: Wu, female, 31 years old; Because sucking continuously " heroin " 11 months, stopping using there is depressed, bradykinesia, hypologia, drowsiness etc. admits to hospital first after 2 days.Because rest, food and drink is bad for a long time, cause absentminded ， Ti Of-thin, through examination in hospital, be diagnosed as diabetes; Fasting glucose 13mmol/L, alanine aminotransferase is 80u, and blood pressure, the heart, lung are normal, and both hands slightly tremble, and urine morphine is checked and examined the positive.Diagnosis: heroin addiction, and suffer from diabetes.Treatment: take medicine of the present invention and check afterwards for 10 days: fasting glucose 8mmol/L, alanine aminotransferase is 44u; Take medicine of the present invention after 15 days, this patient: urine morphine is checked and examined feminine gender, and blood glucose and liver function index full recovery are normal.

Model case 6: patient Chen, man, 42 years old; Drug abuse heroin 4 years, and suffer from hypertension, chronic renal insufficiency, blood test creatinine 175.2umol/l, urine protein 2+, urine morphine qualitative test is positive, ultrasound diagnosis prompting fatty liver, and with itching throat cough, blurred vision; yellow urine, large dry stool, looks into main thin and greasy fur, thready and rolling pulse and string slightly.Chinese medical discrimination has the pathogenesis basis of deficiency of both QI and YIN, channels stasis, has the basic pathogenesis that kidney unit is deficient, the evil poison of turbid damp is not changed, thus treatment first take front and back divide disappear wet toxic removing for will, treat that heresy moves back, then intend QI invigorating righting, tonifying kidney.Treatment: take medicine of the present invention after 15 days, remission, coughs and subtract, but have expectorant in readme pharynx, red tip of the tongue, greasy fur, stool every day 2 times, diet sleep quality takes a turn for the better, and urine morphine qualitative test is negative.Further consultation after two months, conditions of patients is steady, and readme sleep is easily waken up, without cough, greasy fur on tongue, deep pulse, check serum creatinine 137.0umol/l.With anti-, the state of an illness does not increase the weight of.

the specific embodiment

Embodiment 1

Get Radix Astragali 240g, Rhizoma Gastrodiae 300g, Rhizoma Corydalis 700g, Lignum Aquilariae Resinatum 320g, Radix Puerariae 240g, Radix Trichosanthis 140g, Cortex Eucommiae 240g, Bombyx Batryticatus 140, Rhizoma Chuanxiong 300g, Radix Curcumae 300g, Poria cum Radix Pini 140g, succinum 65g, Semen Strychni 27g, Rhizoma Curculiginis 240g, Radix Dipsaci 320g, Radix Paeoniae Alba 300g, Sanguis Draxonis 150g, Radix Notoginseng 150g, Flos Daturae 27g, Radix Angelicae Sinensis 320g, Radix Aconiti Lateralis Preparata 140g, Radix Morindae Officinalis 140g, Radix Salviae Miltiorrhizae 320g, Flos Carthami 65g, Pheretima 140g, Herba Asari 140g, Pericarpium Papaveris 100g, Rhizoma Pinelliae 150g, Rhizoma Et Radix Notopterygii 240g, Ramulus Uncariae Cum Uncis 240g, Radix Asparagi 150g, Radix Ginseng 150g, Rhizoma Atractylodis Macrocephalae 240g, Fructus Jujubae 65g, Folium Pini 695g, Radix Rhodiolae 320g, Hirudo 240g, Cordyceps 140g, Herb Gynostemmae Pentaphylli 240g, by the above-mentioned raw materials preparation method of capsule preparations routinely, through cleaning, oven dry, pulverizing, mix homogeneously, in incapsulating, each capsule packs the medicated powder of 0.5 gram of dosage into.

Embodiment 2

Get Radix Astragali 300g, Rhizoma Gastrodiae 350g, Rhizoma Corydalis 750g, Lignum Aquilariae Resinatum 400g, Radix Puerariae 300g, Radix Trichosanthis 180g, Cortex Eucommiae 300g, Bombyx Batryticatus 180g, Rhizoma Chuanxiong 350g, Radix Curcumae 350g, Poria cum Radix Pini 180g, succinum 115g, Semen Strychni 30g, Rhizoma Curculiginis 300g, Radix Dipsaci 400g, Radix Paeoniae Alba 350g, Sanguis Draxonis 210g, Radix Notoginseng 210g, Flos Daturae 30g, Radix Angelicae Sinensis 400g, Radix Aconiti Lateralis Preparata 180g, Radix Morindae Officinalis 180g, Radix Salviae Miltiorrhizae 400g, Flos Carthami 115g, Pheretima 180g, Herba Asari 180g, Pericarpium Papaveris 170g, Rhizoma Pinelliae 210g, Rhizoma Et Radix Notopterygii 300g, Ramulus Uncariae Cum Uncis 300g, Radix Asparagi 210g, Radix Ginseng 210g, Rhizoma Atractylodis Macrocephalae 300g, Fructus Jujubae 115g, Folium Pini 745g, Radix Rhodiolae 400g, Hirudo 300g, Cordyceps 180g, Herb Gynostemmae Pentaphylli 300g, by the above-mentioned raw materials preparation method of capsule preparations routinely, through cleaning, oven dry, pulverizing, mix homogeneously, in incapsulating, each capsule packs the medicated powder of 0.5 gram of dosage into.

Embodiment 3

Get Radix Astragali 250g, Rhizoma Gastrodiae 310g, Rhizoma Corydalis 710g, Lignum Aquilariae Resinatum 330g, Radix Puerariae 250g, Radix Trichosanthis 150g, Cortex Eucommiae 250g, Bombyx Batryticatus 150g, Rhizoma Chuanxiong 310g, Radix Curcumae 310g, Poria cum Radix Pini 150g, succinum 75g, Semen Strychni 28g, Rhizoma Curculiginis 250g, Radix Dipsaci 330g, Radix Paeoniae Alba 310g, Sanguis Draxonis 160g, Radix Notoginseng 160g, Flos Daturae 28g, Radix Angelicae Sinensis 330g, Radix Aconiti Lateralis Preparata 150g, Radix Morindae Officinalis 150g, Radix Salviae Miltiorrhizae 330g, Flos Carthami 75g, Pheretima 150g, Herba Asari 150g, Pericarpium Papaveris 110g, Rhizoma Pinelliae 160g, Rhizoma Et Radix Notopterygii 250g, Ramulus Uncariae Cum Uncis 250g, Radix Asparagi 160g, Radix Ginseng 160g, Rhizoma Atractylodis Macrocephalae 250g, Fructus Jujubae 75g, Folium Pini 705g, Radix Rhodiolae 330g, Hirudo 250g, Cordyceps 150g, Herb Gynostemmae Pentaphylli 250g, by the above-mentioned raw materials preparation method of capsule preparations routinely, through cleaning, oven dry, pulverizing, mix homogeneously, in incapsulating, each capsule packs the medicated powder of 0.5 gram of dosage into.

Embodiment 4

Get Radix Astragali 290g, Rhizoma Gastrodiae 340g, Rhizoma Corydalis 740g, Lignum Aquilariae Resinatum 390g, Radix Puerariae 290g, Radix Trichosanthis 170g, Cortex Eucommiae 290g, Bombyx Batryticatus 170g, Rhizoma Chuanxiong 340g, Radix Curcumae 340g, Poria cum Radix Pini 170g, succinum 105g, Semen Strychni 29g, Rhizoma Curculiginis 290g, Radix Dipsaci 390g, Radix Paeoniae Alba 340g, Sanguis Draxonis 200g, Radix Notoginseng 200g, Flos Daturae 29g, Radix Angelicae Sinensis 390g, Radix Aconiti Lateralis Preparata 170g, Radix Morindae Officinalis 170g, Radix Salviae Miltiorrhizae 390g, Flos Carthami 105g, Pheretima 170g, Herba Asari 170g, Pericarpium Papaveris 160g, Rhizoma Pinelliae 200g, Rhizoma Et Radix Notopterygii 290g, Ramulus Uncariae Cum Uncis 290g, Radix Asparagi 200g, Radix Ginseng 200g, Rhizoma Atractylodis Macrocephalae 290g, Fructus Jujubae 105g, Folium Pini 735g, Radix Rhodiolae 390g, Hirudo 290g, Cordyceps 170g, Herb Gynostemmae Pentaphylli 290g, by the above-mentioned raw materials preparation method of capsule preparations routinely, through cleaning, oven dry, pulverizing, mix homogeneously, in incapsulating, each capsule packs the medicated powder of 0.5 gram of dosage into.

Embodiment 5

Get Radix Astragali 270g, Rhizoma Gastrodiae 325g, Rhizoma Corydalis 720g, Lignum Aquilariae Resinatum 360g, Radix Puerariae 270g, Radix Trichosanthis 160g, Cortex Eucommiae 270g, Bombyx Batryticatus 160, Rhizoma Chuanxiong 325g, Radix Curcumae 325g, Poria cum Radix Pini 160g, succinum 90g, Semen Strychni 27g, Rhizoma Curculiginis 270g, Radix Dipsaci 360g, Radix Paeoniae Alba 325g, Sanguis Draxonis 180g, Radix Notoginseng 180g, Flos Daturae 27g, Radix Angelicae Sinensis 360g, Radix Aconiti Lateralis Preparata 160g, Radix Morindae Officinalis 160g, Radix Salviae Miltiorrhizae 360g, Flos Carthami 90g, Pheretima 160g, Herba Asari 160g, Pericarpium Papaveris 135g, Rhizoma Pinelliae 180g, Rhizoma Et Radix Notopterygii 270g, Ramulus Uncariae Cum Uncis 270g, Radix Asparagi 180g, Radix Ginseng 180g, Rhizoma Atractylodis Macrocephalae 270g, Fructus Jujubae 90g, Folium Pini 720g, Radix Rhodiolae 360g, Hirudo 270g, Cordyceps 160g, Herb Gynostemmae Pentaphylli 270g, by the above-mentioned raw materials preparation method of capsule preparations routinely, through cleaning, oven dry, pulverizing, mix homogeneously, in incapsulating, each capsule packs the medicated powder of 0.5 gram of dosage into.

Claims (3)

1. a three-hypers capsule falls in Chinese medicinal drug withdrawal, it is characterized in that the medicament that it is made by the raw material of following weight parts proportioning:

The Radix Astragali 240～300 Rhizoma Gastrodiae 300～350 Rhizoma Corydalis 700～750 Lignum Aquilariae Resinatum 320～400

Radix Puerariae 240～300 Radix Trichosanthis 140～180 Cortex Eucommiae 240～300 Bombyx Batryticatus 140～180

Rhizoma Chuanxiong 300～350 Radix Curcumae 300～350 Poria cum Radix Pini's 140～180 succinums 65～115

Semen Strychni 27～30 Rhizoma Curculiginis 240～300 Radix Dipsaci 320～400 Radix Paeoniae Albas 300～350

Sanguis Draxonis 150～210 Radix Notoginseng 150～210 Flos Daturae 27～30 Radix Angelicae Sinensis 320～400

Radix Aconiti Lateralis Preparata 140～180 Radix Morindae Officinalis 140～180 Radix Salviae Miltiorrhizae 320～400 Flos Carthamis 65～115

Pheretima 140～180 Herba Asari 140～180 Pericarpium Papaveris 100～170 Rhizoma Pinelliaes 150～210

Rhizoma Et Radix Notopterygii 240～300 Ramulus Uncariae Cum Uncis 240～300 Radix Asparagi 150～210 Radix Ginsengs 150～210

The Rhizoma Atractylodis Macrocephalae 240～300 Fructus Jujubae 65～115 Folium Pini 695～745 Radix Rhodiolaes 320～400

Hirudo 240～300 Cordyceps 140～180 Herb Gynostemmae Pentaphylli 240～300.

2. three-hypers capsule falls in Chinese medicinal drug withdrawal according to claim 1, it is characterized in that wherein the weight portion proportioning of each crude drug is:

The Radix Astragali 250～290 Rhizoma Gastrodiae 310～340 Rhizoma Corydalis 710～740 Lignum Aquilariae Resinatum 330～390

Radix Puerariae 250～290 Radix Trichosanthis 150～170 Cortex Eucommiae 250～290 Bombyx Batryticatus 150～170

Rhizoma Chuanxiong 310～340 Radix Curcumae 310～340 Poria cum Radix Pini's 150～170 succinums 75～105

Semen Strychni 27～29 Rhizoma Curculiginis 250～290 Radix Dipsaci 330～390 Radix Paeoniae Albas 310～340

Sanguis Draxonis 160～200 Radix Notoginseng 160～200 Flos Daturae 27～29 Radix Angelicae Sinensis 330～390

Radix Aconiti Lateralis Preparata 150～170 Radix Morindae Officinalis 150～170 Radix Salviae Miltiorrhizae 330～390 Flos Carthamis 75～105

Pheretima 150～170 Herba Asari 150～170 Pericarpium Papaveris 110～160 Rhizoma Pinelliaes 160～200

Rhizoma Et Radix Notopterygii 250～290 Ramulus Uncariae Cum Uncis 250～290 Radix Asparagi 160～200 Radix Ginsengs 160～200

The Rhizoma Atractylodis Macrocephalae 250～290 Fructus Jujubae 75～105 Folium Pini 705～735 Radix Rhodiolaes 330～390

Hirudo 250～290 Cordyceps 150～170 Herb Gynostemmae Pentaphylli 250～290.

3. three-hypers capsule falls in Chinese medicinal drug withdrawal according to claim 1, it is characterized in that wherein the weight portion proportioning of each crude drug is:

The Radix Astragali 270 Rhizoma Gastrodiae 325 Rhizoma Corydalis 720 Lignum Aquilariae Resinatum 360

Radix Puerariae 270 Radix Trichosanthis 160 Cortex Eucommiae 270 Bombyx Batryticatus 160

Rhizoma Chuanxiong 325 Radix Curcumae 325 Poria cum Radix Pini's 160 succinums 90

Semen Strychni 27 Rhizoma Curculiginis 270 Radix Dipsaci 360 Radix Paeoniae Albas 325

Sanguis Draxonis 180 Radix Notoginseng 180 Flos Daturae 27 Radix Angelicae Sinensis 360

Radix Aconiti Lateralis Preparata 160 Radix Morindae Officinalis 160 Radix Salviae Miltiorrhizae 360 Flos Carthamis 90

Pheretima 160 Herba Asari 160 Pericarpium Papaveris 135 Rhizoma Pinelliaes 180

Rhizoma Et Radix Notopterygii 270 Ramulus Uncariae Cum Uncis 270 Radix Asparagi 180 Radix Ginsengs 180

The Rhizoma Atractylodis Macrocephalae 270 Fructus Jujubae 90 Folium Pini 720 Radix Rhodiolaes 360

Hirudo 270 Cordyceps 160 Herb Gynostemmae Pentaphylli 270.