CN102579816B - Brain-invigorating tablets and preparation method thereof - Google Patents
Brain-invigorating tablets and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a novel method for preparing brain-invigorating tablets. According to the method, on the basis of the prior art, a unique process for distinguishing and treating different Chinese medicinal herbal components is adopted, so that a curative effect of the prepared brain-invigorating tablets is more obvious, and the problems of incomplete effects of Chinese medicinal components and serious waste in the prior art are solved. According to the method, a preparation process is simple and effective, raw materials are saved, and a high treatment effect is achieved, so the method has a bright market application prospect.
Description
Technical field
The invention belongs to the Chinese medicine technical field of pharmaceuticals, concrete, relate to a kind of brain-invigorating tablet pharmaceutical composition and preparation method thereof.
Background technology
The neurasthenia is a kind of of mental illness, is class spirit excited and mental tired, normal the be in a bad mood neurosis disorder of worry and psychological physiological signs easily easily.The neurasthenia is because the cerebral nerve activity is in tension for a long time, cause the imbalance of brain excitement and inhibit feature and produce one group with easily excitement of spirit, mental fatiguability, symptoms such as emotional instability are function of nervous system's sexual disorders of characteristics.Follow anxiety, conflict, setback and suspect, neurasthenic feature often shows as easy excitement and fatiguability, and serious sleep obstacle and hypomnesis symptom can appear in most of patients.The neurasthenia mainly shows as spirit, and excitement is tired especially easily again especially easily: the excitation time patient often loses control of and recalls and association, a bit stimulates all to be difficult to stand; Most patients can feel mental not enough very soon when tired, feel dizzy, and can not beat spirit, and are absent minded or can not concentrate lastingly, hypomnesis, even tired being short of physical strength from head to foot.Secondly, patient always feels to be nervous, and can loosen, and worried, exciting or fly into a rage especially easily somebody even LA depression or hypochondriacal idea occur.Owing to social competition's pressure, neurasthenic patient deserved to be called the trend of liter in the last few years, and the people who is engaged in mental work suffers from neurasthenic more.Once there was investigation to find that total prevalence rate is 13.03% in 15～59 years old resident, accounts for 58.7% of whole neurosis cases; Seriously influenced people's health.
Doctor trained in Western medicine will be decided on patient's concrete condition aspect the treatment neurasthenia, mainly comprises: 1. Cure for insomnia.The medicine that only is used for the treatment of at present insomnia clinically.Though barbiturates is also being used such as secobarbital etc., because addiction easily, existing few using.2. anxiety and tranquilizing soporific.Various anxiolytic drugs commonly used are such as stable, estazolam, nitrodiazepam, oxazepan, the high logical sequence of A Pu, roller, Flurazepam.Sea Lip river god etc.3. the medicine that uses some to regulate function of nervous system is as brain tonic mixture, the ingredients of many hospitals preparation.4. insulin subcoma therapy etc., but there is defective in these medicines aspect safety and the dependency, easy addiction, and toxic and side effects is serious, should not take for a long time, drug withdrawal easily repeatedly, the state of an illness increases the weight of.
Theory of Chinese medical science thinks that the neurasthenia belongs to categories such as " strongly fragrant disease ", " insomnia ", " asthenia ", " cardiopalmus ", and Chinese medical discrimination is divided into: syndrome of stagnation of liver qi, syndrome of disharmony between heart and kidney, syndrome of deficiency of both heart and spleen.Its pathogenesis belongs to QI and blood and visceral dysfunction more, and deficiency of vital energy blood fortune is not smooth, and channels and collaterals running is obstructed.Treating then unobstructed with QI-blood circulation is principle.Traditional Chinese Medicine experts points out, though all neurastheniacs all are because due to the long-time hypertonicity of ergasia, the disorder of brain excitement inhibit feature, it is different bringing out the root that these situations occur.Lose void, insufficiency of kidney-YANG, hyperactivity of YANG due to deficiency of YIN, deficiency of both the heart and spleen etc. reason as hyperactivity of fire caused by deficiency of YIN, the hepatic and renal YIN deficiency, depression of liver-QI, heart spleen and all can cause the neurasthenia.So treat starting point accordingly yes different, corresponding medicament administration also is different.Chinese medicine is used for the treatment of the neurasthenia namely can addiction, can not produce dependency yet.There are large quantities of high-tech Chinese medicine achievements bringing into play important effect in neurasthenia, Insomnia therapy field, but also have some problems, slow as some drug effect, flavour of a drug are more, are not easy to preparation and use, and effect is not fairly obvious, Time of Administration is long, curative effect instability etc.Therefore, develop a kind of high-efficiency low-toxicity, treating both the principal and secondary aspects of a disease is treated neurasthenic Chinese medicine and is still clinical eager needs.
Brain spirit element is Chinese medicine composition relatively more commonly used in the prior art.Prior art produce the plain producer of brain spirit have ten surplus, its preparation technology is similar, the plain prescription of brain spirit and the preparation technology that all disclose, Rhizoma Polygonati 60g wherein, Herba Epimedii 50g, Fructus Xanthii 40g, Fructus Schisandrae Chinensis 40g, Fructus Lycii 20g, Fructus Jujubae 20g, Radix Polygalae 20g, Radix Rehmanniae Preparata 10g, Radix Ophiopogonis 10g, Semen Ziziphi Spinosae 10g, Poria 10g, Carapax Et Plastrum Testudinis 5g, Colla cornus cervi 2g, Radix Ginseng 2g, Cornu Cervi Pantotrichum 1g, and fabricating technology disclosed specifically: Radix Ginseng, Cornu Cervi Pantotrichum, Colla cornus cervi, Carapax Et Plastrum Testudinis, Radix Polygalae, Poria, Radix Ophiopogonis, Rhizoma Polygonati, Fructus Lycii, Fructus Schisandrae Chinensis, Semen Ziziphi Spinosae, white sugar 30g is ground into fine powder, sieve, four flavors such as all the other Herba Epimedii decoct with water three times, 3 hours for the first time, second, three times respectively is 2 hours, collecting decoction filters, and filtrate is condensed into cream.Condensed cream is added in the above-mentioned fine powder, mixing, oven dry is pulverized, and incapsulates and makes 580, namely.Field of medicaments personnel all know, and the preparation technology of Chinese medicine preparation plays crucial effects to the curative effect of this Chinese medicine.Yet there is more defective in above-mentioned technology, for example can not make that some Effective Components of Chinese Herb is as much as possible to ooze out, to such an extent as to cause the waste of Chinese medicine consumptive material and the not enough refinement of not good and concrete technological process standard of therapeutic effect etc.The maximum effect of the various raw material of Chinese medicine of performance how, and can with other raw material of Chinese medicine compatibility reasonably, reach best therapeutic effect, be the technical problem that prior art needs to be resolved hurrily.
Summary of the invention
The present invention through concentrating on studies for many years, has further optimized the plain preparation technology of brain spirit on the clever plain prescription of the known brain of prior art and preparation technology's thereof basis, and the feasible brain spirit extract for treating effect for preparing is better.
For achieving the above object, the technical solution used in the present invention is as follows:
A kind of preparation technology for neurasthenic brain-invigorating tablet is characterized in that carrying out according to following steps:
The spirit of described brain plain by Rhizoma Polygonati 80g, Fructus Lycii 26.7g, Poria 13.3g, Fructus Xanthii 53.3g, Herba Epimedii 66.6g, Radix Polygalae, 26.7g, Fructus Jujubae 26.7g, Fructus Schisandrae Chinensis 53.3g, Semen Ziziphi Spinosae 13.3g, Radix Ophiopogonis 13.3g, Carapax Et Plastrum Testudinis 6.7g, Cornu Cervi Pantotrichum 1.3g, Colla cornus cervi 2.7g, Radix Rehmanniae Preparata 13.3g and Radix Ginseng 2.7g be prepared from.
Described brain spirit is plain preparation technology carry out according to following steps:
Radix Ginseng, Cornu Cervi Pantotrichum, Colla cornus cervi, Carapax Et Plastrum Testudinis, Radix Polygalae, Poria, Radix Ophiopogonis, the Rhizoma Polygonati of above-mentioned weight are ground into fine powder;
Herba Epimedii, Fructus Xanthii, Fructus Jujubae, Semen Ziziphi Spinosae, Radix Rehmanniae Preparata are decocted with water three times, add for the first time 8 times of amounts of water, decocted 3 hours, and added 6 times of amounts of water for the second time, decocted 2 hours, add 6 times of amounts of water for the third time, decocted 1 hour, gradation filters, merging filtrate, be condensed into the extractum A of relative density 1.3, the Concentrating Process Control temperature is 50 ℃;
Fructus Lycii, Fructus Schisandrae Chinensis decoct with water twice, for the first time add 6 times of amounts of water, decoct 2 hours, add 3 times of amounts of water for the second time, decocted 1 hour, and the gradation filtration, merging filtrate is condensed into the extractum B of relative density 1.2, and the Concentrating Process Control temperature is 50 ℃;
According to the batching mode of fine powder 21g, extractum A 12g, extractum B3g, starch 9g, make bulky grain behind the mix homogeneously, 3 centimetres of diameters, dry below 80 ℃, be ground into fine grained, use 95% alcohol granulation, every 100g is blended into magnesium stearate 1g mix homogeneously, be pressed into 1000, the bag film-coat, namely.
Function with cure mainly: fill blood the kidney that nourishes heart, invigorating brain and relieving mental uneasiness.Be used for the neurasthenia, forgetful insomnia, dizzy cardiopalmus, body is tired unable, the empty spontaneous perspiration of body, impotence and seminal emission.
Usage and dosage: oral, one time 3,3 times on the one.
Attention: the hyperpietic avoids clothes, warm water delivery service.Period in a medicine avoids pungent food and cold and cool food, avoids feelings will to stimulate, and life is regular.
The excellent results that the present invention treats the preparation method of neurasthenic brain-invigorating tablet is:
1. this preparation technology's simple possible has taken into full account the characteristics of each Chinese medicinal components in the preparation process, brought into play the effect of each Chinese medicinal components to greatest extent, has saved the raw material consumptive material, and has improved curative effect;
2. the medicament short treating period for preparing by worker preparation technology of the present invention, the total effective rate height, more the back is difficult for recurrence, obviously is better than like product of the prior art.
The specific embodiment
The present invention is further elaborated below will to adopt the mode of specific embodiment, and what need statement is that those skilled in the art should understand that following specific embodiment should not be construed its limitation of the present invention effect.
Embodiment 1
A kind of preparation technology for neurasthenic brain-invigorating tablet, carry out according to following steps:
This brain-invigorating tablet by Rhizoma Polygonati 80g, Fructus Lycii 26.7g, Poria 13.3g, Fructus Xanthii 53.3g, Herba Epimedii 66.6g, Radix Polygalae, 26.7g, Fructus Jujubae 26.7g, Fructus Schisandrae Chinensis 53.3g, Semen Ziziphi Spinosae 13.3g, Radix Ophiopogonis 13.3g, Carapax Et Plastrum Testudinis 6.7g, Cornu Cervi Pantotrichum 1.3g, Colla cornus cervi 2.7g, Radix Rehmanniae Preparata 13.3g and Radix Ginseng 2.7g be prepared from.
Technology one,
The preparation technology of above-mentioned brain-invigorating tablet carries out according to following steps:
1, Radix Ginseng, Cornu Cervi Pantotrichum, Colla cornus cervi, Carapax Et Plastrum Testudinis, Radix Polygalae, Poria, Radix Ophiopogonis, the Rhizoma Polygonati with above-mentioned weight is ground into fine powder;
2, Herba Epimedii, Fructus Xanthii, Fructus Jujubae, Semen Ziziphi Spinosae, Radix Rehmanniae Preparata are decocted with water three times, add for the first time 8 times of amounts of water, decocted 3 hours, and added 6 times of amounts of water for the second time, decocted 2 hours, add 4 times of amounts of water for the third time, decocted 1 hour, gradation filters, merging filtrate, be condensed into the extractum A of relative density 1.3, the Concentrating Process Control temperature is 50 ℃;
3, Fructus Lycii, Fructus Schisandrae Chinensis decoct with water twice, for the first time add 6 times of amounts of water, decoct 2 hours, add 3 times of amounts of water for the second time, decocted 1 hour, and the gradation filtration, merging filtrate is condensed into the extractum B of relative density 1.2, and the Concentrating Process Control temperature is 50 ℃;
4, according to the batching mode of fine powder 21g, extractum A 12g, extractum B3g, starch 9g, make bulky grain behind the mix homogeneously, 3 centimetres of diameters, dry below 80 ℃, be ground into fine grained, use 95% alcohol granulation, every 100g is blended into magnesium stearate 1g mix homogeneously, be pressed into 1000, the bag film-coat, namely.
Technology two, to prepare brain spirit according to the known Technology of prior art plain:
1 and Radix Ginseng, Cornu Cervi Pantotrichum, Colla cornus cervi, Carapax Et Plastrum Testudinis, Radix Polygalae, Poria, Radix Ophiopogonis, Rhizoma Polygonati, Fructus Lycii, Fructus Schisandrae Chinensis, Semen Ziziphi Spinosae and the white sugar 30g of technology one identical weight be ground into fine powder, sieve;
2, four flavors such as all the other Herba Epimedii decoct with water three times, add 8 times of amounts of water, and 3 hours for the first time, second and third time respectively was 2 hours, and collecting decoction filters, and filtrate is condensed into cream.Condensed cream is added in the above-mentioned fine powder, mixing, oven dry is pulverized, and incapsulates granulation, namely.
Usage and dosage: oral, one time 3,3 times on the one.
Embodiment 2
One, studies on acute toxicity
Healthy rat and mice respectively single oral irritate stomach give technology one preparation of the present invention the neurasthenic brain spirit for the treatment of plain, irritate stomach dosage and be clinical plan consumption 100 times.The light activity minimizing appears in mice after the administration, recovers normal about 1 hour, observes 7 days continuously after the administration, none animal dead, its overall health of patients, diet, to take the photograph water, urine and body weight gain all normal, tangible acute toxic reaction do not occur, also do not cause animal dead.Tangible acute toxic reaction does not appear in mice, and rat occurs having loose bowels just, reactions such as movable minimizing, and the acute toxicity target organ is liver and spleen.Point out this medicine acute toxicity low, clinical drug safety.
Effect experiment: to the influence of length of one's sleep of pentobarbital sodium
Animal: Kunming mouse, male and female half and half, body weight 18～22g, is divided into three groups, 20 every group at random by 60.
Experimental technique: technology two medicine groups of the present invention are as positive control: consumption is 50mg/kg; Technology one medicine group of the present invention, consumption is 50mg/kg; Negative control group: normal saline group.Medicine disposes with distilled water before experiment, gastric infusion.Successive administration 7d, every day 1 time, 1h weighs and lumbar injection 0.3% pentobarbital sodium 0.15ml/10g after the last administration, the influence of recording mice pentobarbital sodium sub-threshold dose syngignoscism in three experimental grouies.
| Group | The example number | The length of one's sleep |
| Positive control | 20 | 63.4±8.2** |
| The present invention | 20 | 81.5±9.4** |
| Negative control | 20 | 30.2±5.1 |
**p＜0.01
The result shows: technology one medicine group of the present invention can obviously reduce mice autonomic activities number of times, compares with technology two medicine groups to have significant difference.
Embodiment 2
1, clinical data
Choose patient's 103 examples with complete data, be divided into two groups immediately, 51 examples are organized in treatment, male 24 examples, and women 27 examples, age 21-63 year, 43 years old mean age, the course of disease 2 months is surplus 10 year.Matched group 52 examples, male 23 examples, women 29 examples, 46.6 years old mean age, the course of disease 1 month to 13 years does not have significant difference at aspects such as sex, age, the courses of disease before two groups of case treatments, has comparability.
Case is selected: the selection of falling ill is the neurasthenia of main symptom with the insomnia and dreamful sleep, and gets rid of organic diseases such as the serious heart, liver, kidney, brain.Differential diagnosis in tcm belongs to the turbid heart type of disturbing of (1) expectorant: insomnia and dreamful sleep, and have that a body is heavy, uncomfortable in chest, dizzy, light red tongue, greasy fur, rolling pulse.(2) type of failure of the heart and kidney integrating: dysphoria and insomnia, dreaminess, dizziness, tinnitus, cardiopalmus, forgetful, few Tianjin of xerostomia, soreness of the loins and nocturnal emission or aphtha of the mouth and tongue, red tip of the tongue, thready and rapid pulse.(3) type of deficiency of heart-QI and gallbladder-QI: insomnia and timid, the shortness of breath and lassitude of cardiopalmus, light red tongue, thready and rapid pulse.(4) type of deficiency of both the heart and spleen: insomnia and dreamful sleep and cardiopalmus are divided forgetful, have a dizzy spell, Mental fatigue, lustreless complexion, white and thin fur, thready and weak pulse.
Therapeutic Method:
The treatment group: technology one medicine group brain-invigorating tablet, three times on the one, one time three, a course for the treatment of two Mondays.
Matched group: technology two medicine group brain-invigorating tablets, three times on the one, one time three, a course for the treatment of two Mondays.
The course for the treatment of and points for attention: two groups of patients are a course for the treatment of with two weeks all, and every case need take just to be counted the people course for the treatment of and add up case, prohibit the clothes class medicine of sleeping peacefully, in order to avoid influence the accuracy of observed result.Observation index: all cases are main symptom with the insomnia and dreamful sleep all,, and carry out classification and observe jointly as observation index in conjunction with picture of the tongue, pulse condition.Neurasthenic other symptom is time card.Such as dizziness, feeling of fullness in the head, fidgety irritability, forgetful cardiopalmus, spiritlessness and weakness etc., the variation of inferior card is represented with (--) (+) (++).(-) is normal, and (+) is normal, and (++) is severe.
Insomnia classification: (1) 0 grade: asymptomatic.(2) I level: difficulty falling asleep, need half an hour sleeping approximately, or the length of one's sleep is short, the aftersensation health of waking up is lighter, or sleep but not soundly, the time back of sleeping, wake up when waking up easily sleeping.(3) II level: difficulty falling asleep, toss about, need can to fall asleep more than half an hour, early awakening, the aftersensation of waking up be drowsy, fatigue and weak or sleep shallowly, in time, sleep when waking up, and the back of waking up is difficult sleeping.(4) III level: lying awake all night or dormancy and dreaminess, is to sleep non-ly to sleep or do not have enough sleep 3-4 hour, though there is sleep weak, symptoms such as dizziness do not have obvious improvement.
Daydream classification: (1) 0 grade: no dream or few dream.(2) I level: it is more to have a dream.(3) II level: daydream is many, and is still drowsy after waking up.(4) III level: dreamland is diverse and confused, and the back of waking up is drowsy.
Therapeutic outcome
Curative effect determinate standard:
1, cure: it is 0 grade that insomnia is had a dream.
2, produce effects: insomnia is had a dream and is improved more than the secondary, or has a sleepless night to have a dream and improve one-level, and inferior card has disappearances more than half.
3, effective: insomnia is had a dream and is improved more than the one-level, the inferior card not enough half that disappears.
4, invalid: insomnia is had a dream of not having and is improved.
1, it is as follows that total effects sees Table 1 concrete therapeutic outcome: P＜0.05
As seen from the above table: the cure rate of technology one medicine group relieving neurasthenia and total effective rate all obviously are better than technology two medicine groups, and significant difference is arranged.
Embodiment 3
Exemplary embodiments
Complete certain, the woman, 22 years old, students were because the study anxiety causes insomnia, spiritual poor, headache and dizzy etc.Since close on graduation, sx, and sensory learning is difficult to be competent at, last class hour is noted not concentrating, hypomnesis is read a book with regard to vexed headache the emotion irritability, often sigh endlessly because of minor matter, take a turn for the better to some extent when meeting the happiness thing, sleep in evening difference companion dreaminess, daytime lethargy, insobriety, general fatigue is unable, once does many inspections to hospital and does not all find organic disease, takes oryzanol, Drug therapy such as stable is many half a year, do not see and be clearly better, mood is heavier, occurs tired behaviour sometimes, depressed, it is also even more serious to have a sleepless night, and is diagnosed as " neurasthenia ", the brain-invigorating tablet that begins to take one preparation of embodiment 1 technology cooperates therapy at heart a course for the treatment of, one the course for the treatment of aftersensation respond well, continue to strengthen course for the treatment of of treatment, present one feels and can sleep to daybreak, the back spirit of getting up morning is fine, and memory has clear improvement.
Poplar, man 35 years old, nearest 2 years, because operating pressure is big, often overtime work was stayed up late, and life does not have rule, difficulty falling asleep, the shallow dreaminess of sleeping, and often lie awake all night.The visible positive effect of initial stage clothes Western medicine sleeping pill, degradation failure is increased the weight of with the state of an illness in the back.Recent months, often to lie awake all night, daytime, dizzy head was heavy, weak, neurolysis, tinnitus and soreness of loins, hypomnesis, susceptible to lose temper due to restlessness is on tenterhooks inappetence; Lassitude of the limbs and weakness, health diurnal inequality, cisco unity malfunction.Suffer from the neurasthenia on inspection, take the brain-invigorating tablet of embodiment 1 technology 1 after 2 courses for the treatment of, it is normal gradually to sleep, and has a dizzy spell, and health is weak to wait disease disappearance, continue to take 2 courses for the treatment of again after, on inspection, neurasthenia's recovery from illness.
The present invention adopts the unique preparation process technology on the basis of existing technology, makes that to prepare the plain curative effect of brain spirit more remarkable, and it is not thorough to have overcome in the prior art Chinese medicinal components performance effect, wastes serious problem.Preparation technology of the present invention is simply effective, has saved raw material, and has given play to higher therapeutic efficiency, possesses superior market application foreground.
Claims (2)
1. preparation method that is used for the treatment of neurasthenic brain-invigorating tablet is characterized in that carrying out according to following steps: described brain-invigorating tablet by Rhizoma Polygonati 80g, Fructus Lycii 26.7g, Poria 13.3g, Fructus Xanthii 53.3g, Herba Epimedii 66.6g, Radix Polygalae 26.7g, Fructus Jujubae 26.7g, Fructus Schisandrae Chinensis 53.3g, Semen Ziziphi Spinosae 13.3g, Radix Ophiopogonis 13.3g, Carapax Et Plastrum Testudinis 6.7g, Cornu Cervi Pantotrichum 1.3g, Colla cornus cervi 2.7g, Radix Rehmanniae Preparata 13.3g and Radix Ginseng 2.7g be prepared from;
The plain preparation method of described brain spirit is carried out according to following steps:
1) Radix Ginseng, Cornu Cervi Pantotrichum, Colla cornus cervi, Carapax Et Plastrum Testudinis, Radix Polygalae, Poria, Radix Ophiopogonis, the Rhizoma Polygonati with above-mentioned weight is ground into fine powder;
2) Herba Epimedii, Fructus Xanthii, Fructus Jujubae, Semen Ziziphi Spinosae, the Radix Rehmanniae Preparata with above-mentioned weight decocts with water three times, add for the first time 8 times of amounts of water, decocted 3 hours, and added 6 times of amounts of water for the second time, decocted 2 hours, add 6 times of amounts of water for the third time, decocted 1 hour, gradation filters, merging filtrate, be condensed into the extractum A of relative density 1.3, the Concentrating Process Control temperature is 50 ℃;
3) Fructus Lycii, the Fructus Schisandrae Chinensis with above-mentioned weight decocts with water twice, adds 6 times of amounts of water for the first time, decocts 2 hours, for the second time add 3 times of amounts of water, decocted 1 hour, gradation filters, merging filtrate is condensed into the extractum B of relative density 1.2, and the Concentrating Process Control temperature is 50 ℃;
4) according to the batching mode of fine powder 21g, extractum A 12g, extractum B3g, starch 9g, make bulky grain behind the mix homogeneously, 3 centimetres of diameters, dry below 80 ℃, be ground into fine grained, use 95% alcohol granulation, every 100g is blended into magnesium stearate 1g mix homogeneously, be pressed into 1000, the bag film-coat, namely.
2. the brain-invigorating tablet that obtains according to the described preparation method of claim 1.
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| CN107823428A (en) * | 2017-11-06 | 2018-03-23 | 贵州拜特制药有限公司 | Application of the plain preparation of brain spirit in anti-curing oncoma and its complication medicine is prepared |
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| C14 | Grant of patent or utility model | ||
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| C56 | Change in the name or address of the patentee |
Owner name: XIANGYU PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: SHANDONG XIANGYU HEALTH PHARMACEUTICAL CO., LTD. |
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Address after: 276023 No. 30, Hangzhou Road, Linyi economic and Technological Development Zone, Linyi, Shandong Patentee after: Xiang Yu Pharmaceutical limited company Address before: 276023 No. 30, Beijing Road, Linyi Economic Development Zone, Shandong, Linyi Patentee before: Shandong Xiangyu Health Pharmaceutical Co., Ltd. |