CN102764340B - Traditional Chinese medicine composite capable of improving sleep and preparation method and application thereof - Google Patents
Traditional Chinese medicine composite capable of improving sleep and preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to the traditional Chinese medicine field, and discloses a traditional Chinese medicine composite capable of improving sleep and a preparation method and an application thereof. The traditional Chinese medicine composite is composed of bulk pharmaceutical chemicals of 7 to 10 parts of spina date seeds, 5 to 8 parts of lucid ganoderma, 6 to 9 parts of Poria and 3 to 6 parts of wolfberry. According to the traditional Chinese medicine composite capable of improving sleep and the preparation method and the application thereof, the formula is reasonable and optimized, four kinds of natural traditional Chinese medicines are finely prepared into an efficient and safe traditional Chinese medicine composite which is provided with functions of improving sleep, calming nerves, nourishing bleed and colors and the like, capable of effectively relieving and curing sleep disorders or palpitation and insomnia caused by mental disorders, neural decline, depression and anxiety, malaise and the like for learning and work pressures, no toxic and side effect and drug dependence exist for human bodies, the composite is superior to Chinese herba preparation products, and can be widely applied in medicine preparation for improving sleep and curing insomnia.
Description
Technical field
The present invention relates to tcm field processed, be specifically related to a kind of Chinese medicine composition that improves sleep and its preparation method and application.
Background technology
Modern society's rhythm of life is accelerated gradually, increasingly competitive, thereby causes insomnia, anxiety patient to grow with each passing day.According to statistics, the insomnia rate in the crowd of developed country reaches 15-30%.China insomniac is also in rising trend in recent years, has its people of 20-30% to suffer from insomnia in various degree, and old group insomnia rate is especially up to 40%.Insomnia is often can not obtain because lack of preservation of spirit or irritability cause the class disease that ortho sleep is feature, main manifestations be the length of one's sleep deficiency, Depth of sleep not enough and can not allaying tiredness, regain one's strength and energy, the lighter's difficulty falling asleep, or sleep but not soundly, or sometimes sleeping and sometimes waking, or can not sleep again after waking up; Heavy be insomnia all night.Due to the not enough of the length of one's sleep or sleep not yet done, common spiritlessness and weakness after waking up, dizziness headache, the symptoms such as palpitation and amnesia and malaise.Insomnia, anxiety not only affect people's work and rest orthobiosis and work, and can reduce immunity, have a strong impact on health.
Cure for insomnia is mainly take synthetic drug as main at present, and the main employing of western medical treatment insomnia is calm, hypnotic drug, as benzodiazepine and barbiturate.But this class medicine life-time service has certain side effect, as have a dizzy spell, weak etc., easily affect memory, and easily cause drug dependence, thus find can hypnotic natural plant very necessary.
Compared with Western medicine, Chinese medicine has higher safety.At present, the Chinese medicine preparation of Cure for insomnia has to calm the nerves determines intelligence ball, Tianwang Buxin Dan, mind-easing tonic bolus with arborvitate seed, yangxue anshen pills etc., although above-mentioned these Chinese patent medicines are obtained certain therapeutic effect for insomnia, but in former three, all contain calm mineral medicine Cinnabaris of calming the nerves, can cause certain injury to human body; And in yangxue anshen pills, contain Caulis Polygoni Multiflori, and long-term taking, its contained anthraquinone analog compound can cause serious liver toxicity.
In addition, the prescription of above-mentioned Chinese patent medicine is main mainly with nourishing blood to tranquillize the mind, is mainly to regulate for each organ of human body, so that therapeutic effect is not good.Therefore the tcm product of, researching and developing a kind of efficient, safe improvement sleep has significant society and economic benefit prospect to human society.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of sleep Chinese medicine composition and its preparation method and application that improves, make described Chinese medicine composition can improve the therapeutic effect to insomnia, significantly improve sleep state, and safe, have no side effect.
To achieve these goals, the invention provides following technical scheme:
Improve a Chinese medicine composition for sleep, made by the crude drug of following weight portion:
Semen Ziziphi Spinosae 7-10 part, Ganoderma 5-8 part, Poria 6-9 part, Fructus Lycii 3-6 part, be more preferably made up through ethanol extraction of above-mentioned raw materials medicine.
Wherein, described raw material medicines in portions by weight number is preferably:
8 parts of Semen Ziziphi Spinosaes, 5 parts of Ganodermas, 6 parts, Poria, 3 parts of Fructus Lyciis.
The defect that curative effect is undesirable, Western medicine toxic and side effects is larger for existing traditional Chinese medicine preparation product to insomnia, reasonably optimizing formula of the present invention, select four kinds of purification of tcm to form a kind of brand-new Chinese medicine composition, guaranteeing under the prerequisite of safety, there is good effect to improving sleep, solved the defect of existing medicament for treating insomnia.
Chinese medicine composition of the present invention is under Chinese medical theory instructs, achievement in research in conjunction with modern Chinese medicine pharmacy to insomnia, in conjunction with applicant's research practice experience for many years, filter out and improve sleep, calm calming the nerves, the nourish blood crude drug of skin care, according to theory of Chinese medical science prescription, forms according to certain weight prescription.Semen Ziziphi Spinosae has the tonifying liver of nourishing heart, mind tranquilizing and the heart calming, arresting sweating, the effect of promoting the production of body fluid, and can be used for restlessness of asrhenia type and insomnia and palpitation with fear dreaminess; Ganoderma has invigorating QI and tranquilization, cough and asthma relieving efficacy, for malaise and insomnia cardiopalmus; Poria has mind calming spleen invigorating, promoting diuresis to eliminate damp pathogen effect, for the insomnia of palpitating with fear, irritability, edema diuresis, phlegm retention vertigo and palpitation; Fructus Lycii has nourishing the liver and kidney, nourishing the liver to improve visual acuity effect, can be used for asthenia damage of essence, vertigo and tinnitus, blood pressure lowering, blood fat reducing and improves immune function of human body.
Above-mentioned various crude drug synergism, can effectively alleviate and treat the sleep disorder or the palpitation and insomnia that cause because of study and work pressure mental maladjustment, neural decline, depressive anxiety, irritability etc.In addition, this Chinese medicine composition, both without any toxicity, also without any drug dependence, can be applicable in the medicine of preparation improvement sleep and Cure for insomnia.
Improve sleep and control in the application of medicine of insomnia in preparation, Chinese medicine composition of the present invention can be prepared into various conventional formulations clinically by this area conventional formulation method, for example, can in the Chinese medicine composition of effective dose of the present invention, add pharmaceutically acceptable adjuvant (such as disintegrating agent, lubricant, adhesive, dispersant etc.), be prepared into various medicinal preparation for oral administration, the present invention preferably makes tablet, granule, capsule, powder, pill or oral liquid.
To those skilled in the art, in the situation that knowing active component, can, according to conventional formulation method, make easily various pharmaceutical products, the adjuvant adopting in preparation also for well known in the art, as carboxymethylstach sodium, cane sugar powder, Mel, Semen Sesami wet goods simultaneously.
The present invention also provides a kind of preparation method of the Chinese medicine composition that improves sleep, in weight portion, and weighting raw materials Semen Ziziphi Spinosae 7-10 part, Ganoderma 5-8 part, Poria 6-9 part and Fructus Lycii 3-6 part, after ethanol extraction crude drug, gained filtrate is described Chinese medicine composition.
Wherein, described raw material medicines in portions by weight number is preferably:
8 parts of Semen Ziziphi Spinosaes, 5 parts of Ganodermas, 6 parts, Poria, 3 parts of Fructus Lyciis.
The ethanol extraction method adopting in preparation method of the present invention is the conventional extracting method in this area, can be percolation, infusion process or reflux extraction, as preferably, preparation method preferred alcohol reflux, extract, crude drug of the present invention, operating procedure more preferably:
With 5-7 doubly to the 50-90% of crude drug gross weight ethanol, more preferably 80% ethanol, reflux, extract, crude drug 1-2 time, at every turn 60min.
In addition, make more easily various medicaments for the ease of Chinese medicine composition of the present invention, preparation method of the present invention also comprises:
Below 60 ℃, the filtrate of gained after ethanol extraction is condensed into thick paste.
Wherein, the relative density of described thick paste is preferably 1.10-1.15.
In the mice contrast test of the Chinese medicine composition outside Chinese medicine preparation mind-easing tonic bolus with arborvitate seed, anshen dingzhi wan and the formula range of the present invention of Chinese medicine composition of the present invention and existing Cure for insomnia, Chinese medicine composition of the present invention can effectively reduce the mice autonomic activities time, increases the length of one's sleep and improve sleep rate, and effect is better than a contrast group.
Meanwhile, in the research of the acute toxicity to Chinese medicine composition of the present invention and long term toxicity, do not find that Chinese medicine composition of the present invention has any untoward reaction, to each organ not damaged.In clinical trial, Chinese medicine composition of the present invention has obvious curative effect to patient's insomnia, has greatly improved sleep quality, and has no side effect and drug dependence.
From above technical scheme, reasonably optimizing formula of the present invention, adopt four kinds of natural Chinese medicine exquisitenesses to form a kind of efficient, safe Chinese medicine composition, there is the sleep of improvement, calm calming the nerves, the effects such as skin care nourish blood, can effectively alleviate and treat the sleep disorder or the palpitation and insomnia that cause because of study and work pressure mental maladjustment, neural decline, depressive anxiety, irritability etc., and human body is had no side effect and drug dependence type, be better than existing traditional Chinese medicine preparation product, can be widely used in improving in the medicine preparation of sleep and Cure for insomnia.
The specific embodiment
The invention discloses a kind of Chinese medicine composition that improves sleep and its preparation method and application, those skilled in the art can use for reference content herein, suitably improve technological parameter and realize.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the artly, they are all deemed to be included in the present invention.Product of the present invention and preparation method are described by preferred embodiment, related personnel obviously can change methods and applications as herein described in content of the present invention, spirit and scope or suitably change and combination not departing from, and realizes and apply the technology of the present invention.
Be described further with regard to a kind of Chinese medicine composition that improves sleep provided by the present invention and its preparation method and application below.
Embodiment 1: the capsule of preparing Chinese medicine composition of the present invention
Take each raw material (unit: g): Semen Ziziphi Spinosae 800, Ganoderma 500, Poria 600, Fructus Lycii 300 by following weight;
Get Semen Ziziphi Spinosae, Ganoderma, Poria, Fructus Lycii, add 6 times to 80% alcohol reflux of crude drug gross weight 2 times, each 60min, filters, and filtrate is evaporated to the thick paste that relative density is 1.10-1.15 below at 60 ℃, spraying is dry, add carboxymethylstach sodium, fully mix, granulation, pack capsule into No. 1, obtain capsule.
Embodiment 2: the tablet of preparing Chinese medicine composition of the present invention
Take each raw material (unit: g): Semen Ziziphi Spinosae 700, Ganoderma 600, Poria 700, Fructus Lycii 400 by following weight;
Get Semen Ziziphi Spinosae, Ganoderma, Poria, Fructus Lycii, add 5 times to 60% alcohol reflux of crude drug gross weight 2 times, each 60min, filter, filtrate is evaporated to the thick paste that relative density is 1.10-1.15 below at 60 ℃, and spraying is dry, adds carboxymethylstach sodium, fully mix, send into tablet machine and make tablet.
Embodiment 3: the granule of preparing Chinese medicine composition of the present invention
Take each raw material (unit: g): Semen Ziziphi Spinosae 1000, Ganoderma 800, Poria 900, Fructus Lycii 600 by following weight;
Get Semen Ziziphi Spinosae, Ganoderma, Poria, Fructus Lycii, add 7 times to 50% alcohol reflux of crude drug gross weight 2 times, each 60min, filter, filtrate is evaporated to the thick paste that relative density is 1.10-1.15 below at 60 ℃, and spraying is dry, then adds the mixture of cane sugar powder and carboxymethylstach sodium, mix granulation agent.
Embodiment 4: the pill of preparing Chinese medicine composition of the present invention
Take each raw material (unit: g): Semen Ziziphi Spinosae 900, Ganoderma 700, Poria 800, Fructus Lycii 500 by following weight;
Get Semen Ziziphi Spinosae, Ganoderma, Poria, Fructus Lycii, add 6 times to 90% alcohol reflux of crude drug gross weight 1 time, 60min, filter, filtrate is evaporated to the thick paste that relative density is 1.10-1.15 below at 60 ℃, spraying is dry, then adds pure Oleum sesami or Mel to mix, and delivers to the centrifugal ball machine of making and makes pill.
Embodiment 5: the pharmacy test of Chinese medicine composition of the present invention to mice
1, experimental animal: 96 of Kunming mouses, purchased from Hainan Medical College's Experimental Animal Center, male and female half and half, average weight is 20g.
2, test grouping: mice is divided into eight groups, be respectively medicine of the present invention (thick paste that embodiment 1 is prepared) group, drugs compared 1 test group, drugs compared 2 test group, drugs compared 3 test group, drugs compared 4 test group, calm the nerves and determine intelligence ball (commercially available) group, mind-easing tonic bolus with arborvitate seed (commercially available) group and blank group, every group of male and female half and half.
Wherein, the formula of drugs compared 1-4 group is outside crude drug compositional range of the present invention, and extracting method is with embodiment 1, and each group of formula is as follows:
Drugs compared 1 test group: Semen Ziziphi Spinosae 200g, Ganoderma 300g, Poria 600g, Fructus Lycii 500g;
Drugs compared 2 test group: Ganoderma 200g, Poria 500g, Fructus Lycii 100g;
Drugs compared 3 test group: Semen Ziziphi Spinosae 500g, Poria 300g, Fructus Lycii 300g;
Drugs compared 4 test group: Semen Ziziphi Spinosae 300g, Ganoderma 100g, Fructus Lycii 200g;
3, the impact test of medicine on mice autonomic activities
By tested medicine water obtaining liq, give mouse stomach, in effective ingredient, medicine group dosage of the present invention is each 4g/Kg; Positive controls is taken to calm the nerves and is determined intelligence ball and mind-easing tonic bolus with arborvitate seed, and dosage is 3g/Kg, 20 times of the dosage of being grown up; The dosage of drugs compared 1 test group, drugs compared 2 test group, drugs compared 3 test group, drugs compared 4 test group is 4g/Kg; Blank group water replaces medicine of the present invention, and gavage volume is identical with medicine group of the present invention.After 60min, mice is placed in to toy autonomic activities analyzer, mice autonomic activities number of times in meter 10min, the results are shown in Table 1.
The affect result of the test of table 1 medicine on mice autonomic activities
| Grouping | Dosage (g/Kg) | Movable number of times in 10min |
| Blank group | 0 | 182.4±39.1 |
| Mind-easing tonic bolus with arborvitate seed | 3 | 130.5±11.2 |
| Calm the nerves and determine intelligence ball | 3 | 126.9±18.7 |
| Medicine group of the present invention | 4 | 122.4±19.5 |
| Drugs compared 1 test group | 4 | 146.6±19.2 |
| Drugs compared 2 test group | 4 | 141.5±17.9 |
| Drugs compared 3 test group | 4 | 153.7±20.3 |
| Drugs compared 4 test group | 4 | 148.2±16.3 |
As shown in Table 1, after medicine group gastric infusion of the present invention, can obviously reduce mice autonomic activities number of times.Illustrate that medicine of the present invention has obvious sedation to mice, its successful is higher than drugs compared 1 test group, drugs compared 2 test group, drugs compared 3 test group and drugs compared 4 test group, and is better than calming the nerves and determines intelligence ball group and mind-easing tonic bolus with arborvitate seed group.Show that Chinese medicine composition of the present invention can improve sleep state, calm calming the nerves, effectively treats sleep disorder or palpitation and insomnia.
4, the syngignoscism of medicine to subthreshold hypnotic dosage pentobarbital sodium mice
Get 96 of Kunming mouses, grouping and administering mode are with 1,2,3,60min after gastric infusion, respectively organizes respectively lumbar injection 30mg/kg pentobarbital sodium of mice, observes each group mice rate (reaching the above person of 1min for falling asleep with righting reflex loss) of falling asleep that gives after pentobarbital sodium in 30min.Add up the each group of mice rate of falling asleep, the results are shown in Table 2.
The syngignoscism of table 2 medicine to subthreshold hypnotic dosage pentobarbital sodium mice
| Grouping | Dosage (g/Kg) | Mice (only) falls asleep | The rate of falling asleep (%) |
| Blank group | 0 | 3 | 25 |
| Mind-easing tonic bolus with arborvitate seed | 3 | 9 | 75 |
| Calm the nerves and determine intelligence ball | 3 | 9 | 75 |
| Medicine group of the present invention | 4 | 11 | 92 |
| Drugs compared is tested 1 group | 4 | 9 | 75 |
| Drugs compared is tested 2 groups | 4 | 8 | 67 |
| Drugs compared is tested 3 groups | 4 | 9 | 75 |
| Drugs compared is tested 4 groups | 4 | 8 | 67 |
As shown in Table 2, medicine of the present invention can obviously increase mice that sub-threshold dose pentobarbital sodium the causes number of falling asleep.Illustrate that medicine of the present invention has maincenter sedative-hypnotic effect to mice, its hypnotic effect is better than drugs compared 1 test group, drugs compared 2 test group, drugs compared 3 test group, drugs compared 4 test group and calms the nerves and determine intelligence ball and mind-easing tonic bolus with arborvitate seed.Show that Chinese medicine composition of the present invention can improve sleep state, calm calming the nerves, effectively treats sleep disorder or palpitation and insomnia.
5, the impact of medicine on HD pentobarbital sodium mouse sleep time
Get 96 of Kunming mouses, grouping and administering mode are with 1,2,3,60min after gastric infusion, each group mice lumbar injection HD pentobarbital sodium 50mg/kg respectively, the observed and recorded animal sleep persistent period (take righting reflex loss to recovering required time as standard recording), the results are shown in Table 3.
The impact of table 3 medicine on HD pentobarbital sodium mouse sleep time
| Grouping | Dosage (g/Kg) | The length of one's sleep (min) |
| Blank group | 0 | 75.1±16.3 |
| Mind-easing tonic bolus with arborvitate seed | 3 | 102.3±12.9 |
| Calm the nerves and determine intelligence ball | 3 | 105.8±17.8 |
| Medicine group of the present invention | 4 | 115.7±15.2 |
| Drugs compared is tested 1 group | 4 | 94.4±17.6 |
| Drugs compared is tested 2 groups | 4 | 92.8±13.8 |
| Drugs compared is tested 3 groups | 4 | 96.2±11.5 |
| Drugs compared is tested 4 groups | 4 | 95.3±18.4 |
As shown in Table 3, medicine of the present invention can obviously extend the length of one's sleep of HD pentobarbital sodium mice, and be obviously longer than drugs compared 1 test group, drugs compared 2 test group, drugs compared 3 test group and drugs compared 4 test group the length of one's sleep, being also better than calms the nerves determines intelligence ball and mind-easing tonic bolus with arborvitate seed.Show that Chinese medicine composition of the present invention can improve sleep state, calm calming the nerves, effectively treats sleep disorder or palpitation and insomnia.
Above-mentioned pharmacy test presentation of results, the Chinese medicine composition that Semen Ziziphi Spinosae, Ganoderma, Poria, Fructus Lycii reasonable compatibility are obtained together afterwards, between each component, have the pharmacological effect of significant Synergistic, have better calmness, hypnotic activity, drug effect is better than calming the nerves and determines intelligence ball and mind-easing tonic bolus with arborvitate seed.
Embodiment 6: Chinese medicine composition toxicity research of the present invention
1, studies on acute toxicity
Get Kunming mouse, administering mode, with 3 in embodiment 5, gives medicine of the present invention (thick paste that embodiment 1 is prepared) by 10g/kg gavage, 1 day successive administration 4 times, every minor tick 6h, then gives normal diet, each organ is carried out to pathologic inspection, do not find organ disease.
2, long term toxicity research
Get Kunming mouse, administering mode is with 3 in embodiment 5, in pressing, heavy dose of group of (4g/kg, 8g/kg) gavage gives medicine of the present invention (thick paste that embodiment 1 is prepared), every day 1 time, successive administration, after 14 days, is measured the indexs such as Mouse Weight, cardiac function, liver function, renal function, electrocardiogram, administration group respectively with matched group comparison, show no obvious abnormalities.The internal organs such as the pathological examination heart, liver,kidney,spleen, lung, Stomach duodenum, large intestine, small intestinal, adrenal gland and genitals, administration group respectively with matched group comparison, be showed no obvious toxic and change.Above result shows Chinese medicine composition safety non-toxic of the present invention, can be used for clinical.
Embodiment 7: the clinical trial of Chinese medicinal composition preparation of the present invention
1, diagnostic criteria
Press Chinese Spirit classification of diseases scheme and relevant insomnia (307.4 in diagnostic criteria second edition revised edition (CCMD-2-R); F51.0) diagnostic criteria is diagnosed, be that insomnia refers to the unsatisfied situation of quality and quantity to sleep that continues the long duration, can not be using the main standard of statistical ortho sleep time as diagnosis insomnia, there are worry or the feared state of mind can form vicious cycle to insomnia, thereby make symptom sustainable existence: (1) is take sleep disorder as almost only symptom, other symptoms are all secondary to insomnia, comprise have difficulty in going to sleep, insomnia-middle, easily wake up, dreaminess, early awakening, be difficult for sleeping again, wake up after waking up after sense uncomfortable, tired or daytime is sleepy; (2) above-mentioned sleep disorder at least occurs weekly three times, and continues more than one month; (3) insomnia causes significant worries, or ergasia decrease in efficiency, or hinders social function; (4) not a part for any physical disease or mental disorder symptom.
2, efficacy assessment standard
In " the disease of tcm Standardization of diagnosis and curative effect " delivered for 1994 with reference to the State Administration of Traditional Chinese Medicines, related content is carried out efficacy evaluation.
Cure: insomnia disappears, and time for falling asleep and the length of one's sleep are normal, in 1 hour, fall asleep, and the SAN time exceedes 5 hours;
Effective: insomnia makes moderate progress, time for falling asleep and the length of one's sleep normal;
Invalid: insomnia is without significant change, and time for falling asleep and the length of one's sleep are undesired.
3, experimenter's inclusive criteria
18-55 year, is insomniac after diagnosing, and wherein under-18s more than 55 years old, serious primary disease, psychotic, is taken the medicine relevant with pharmic function of the present invention or food in a short time, and impact is to except result judgement person.
4, grouping
The 150 routine insomnia experimenters that meet experimenter's inclusive criteria, are divided into treatment group, positive controls and blank group at random, every group of 50 examples, and men and women half and half, and average course of disease is 1.50 ± 0.7 years.Treatment group is taken the embodiment of the present invention 1 medicament capsule, and consumption is 12g/ day, before sleeping every night, once takes.Positive controls is taken commodity medicine mind-easing tonic bolus with arborvitate seed water-honeyed pill, each 1 ball (9g), every day 2 times.Blank group is taken blank placebo, the same treatment group of usage and dosage.
5, observation of curative effect
Table 4 sleep quality
| Group | Number of cases | Average time for falling asleep/min | The average length of one's sleep/h |
| Treatment group | 50 | 22±7 | 7.6±0.2 |
| Positive controls | 50 | 40±9 | 6.9±0.5 |
| Blank group | 50 | 83±6 | 4.5±0.4 |
Table 5 have a sleepless night cardinal symptom improve situation
From table 4 and table 5, the average time for falling asleep for the treatment of group is significantly shorter than positive controls and blank group, is significantly longer than positive controls and blank group the average length of one's sleep.Wherein treatment group patient's clinical symptoms improves significantly, and shows as significant therapeutic efficiency.
6, toxic and side effects observed result: in the patient who treats, do not have a routine patient to occur any untoward reaction, illustrate that medicine of the present invention is safe to human body.
Above-mentioned clinical observation result shows that Chinese medicine composition of the present invention is evident in efficacy to improving sleep and Cure for insomnia symptom, has no side effect, without drug dependence.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. a Chinese medicine composition that improves sleep, is characterized in that, is made up through alcohol reflux of the crude drug of following weight portion:
Semen Ziziphi Spinosae 7-10 part, Ganoderma 5-8 part, Poria 6-9 part, Fructus Lycii 3-6 part.
2. Chinese medicine composition according to claim 1, is characterized in that, described raw material medicines in portions by weight number is:
8 parts of Semen Ziziphi Spinosaes, 5 parts of Ganodermas, 6 parts, Poria, 3 parts of Fructus Lyciis.
3. the application of Chinese medicine composition in the medicine of preparation improvement sleep and Cure for insomnia described in claim 1 or 2.
4. a Chinese medicine preparation that improves sleep, is characterized in that, is made up of Chinese medicine composition described in the claim 1 or 2 of effective dose and pharmaceutically acceptable adjuvant.
5. Chinese medicine preparation according to claim 4, is characterized in that, it is tablet, granule, capsule, powder, pill or oral liquid.
6. a preparation method of improving the Chinese medicine composition of sleep, is characterized in that, in weight portion, and weighting raw materials Semen Ziziphi Spinosae 7-10 part, Ganoderma 5-8 part, Poria 6-9 part and Fructus Lycii 3-6 part, after ethanol extraction crude drug, gained filtrate is described Chinese medicine composition.
7. preparation method according to claim 6, is characterized in that, described ethanol extraction crude drug is alcohol reflux crude drug.
8. preparation method according to claim 7, is characterized in that, described alcohol reflux crude drug be with 5-7 doubly to the 50-90% of crude drug gross weight alcohol reflux crude drug 1-2 time, 60min at every turn.
9. preparation method according to claim 6, is characterized in that, also comprises:
Below 60 ℃, the filtrate of gained after ethanol extraction is condensed into thick paste.
10. preparation method according to claim 9, is characterized in that, the relative density of described thick paste is 1.10-1.15.
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| CN116327870A (en) * | 2023-05-19 | 2023-06-27 | 上海市第七人民医院(上海中医药大学附属第七人民医院) | Composition for relieving insomnia symptom, application, medicine and preparation method |
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| CN101474347A (en) * | 2007-12-31 | 2009-07-08 | 天津中新药业研究中心 | Oral solid preparation for promoting sleep and preparation method thereof |
| CN102068555A (en) * | 2009-11-25 | 2011-05-25 | 王念军 | Medicinal composition for improving sleep and preparation method thereof |
| CN102172383A (en) * | 2011-01-12 | 2011-09-07 | 涂传荣 | Chinese medicinal preparation having functions of enhancing immunity, promoting digestion and improving sleep |
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