CN101653555B - Chinese medicine composition for treating insomnia and anxiety and preparation method thereof - Google Patents
Chinese medicine composition for treating insomnia and anxiety and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicine composition for treating insomnia and anxiety and a preparation method thereof, belonging to the field of Chinese medicine treatment for insomnia. The Chinese medicine composition comprises the following drugs in portions by weight: 2-4 portions of agilawood, 2-5 portions of shelled cedar seed, 5-8 portions of wild jujube seed, 1-4 portions of tuber of dwarf lilyturf and 1-4 portions of liquorice. The toxicity research experiment proves that the Chinese medicine composition has no any toxic or side effect and no drug dependence. Clinical curative effect observation experiments indicate that the Chinese medicine composition has obvious curative effect on insomnia and anxiety.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition calm, the hypnosis effect that has, the invention still further relates to the preparation method of this Chinese medicine composition, belong to the treatment by Chinese herbs field of insomnia.
Background technology
Modern society's rhythm of life is accelerated gradually, and is increasingly competitive, thereby causes insomnia, anxiety patient to grow with each passing day.According to statistics, the insomnia rate among the crowd of developed country reaches 15-30%.The insomniac of China is also in rising trend in recent years.According in March, 2008 statistics, China has 300,000,000 people existence sleep disorder in various degree approximately.Insomnia, anxiety not only affect people's work and rest orthobiosis and work, and can reduce immunity, have a strong impact on health.
Calm, the hypnotic drug of the main employing of western medical treatment insomnia at present is as benzodiazepine and barbiturate.But this class medicine life-time service influences memory easily, and easily causes drug dependence.The Chinese patent medicine of Cure for insomnia has to calm the nerves decides intelligence ball, Tianwang Buxin Dan, mind-easing tonic bolus with arborvitate seed, yangxue anshen pills etc., though above-mentioned these Chinese patent medicines are obtained certain therapeutic effect for insomnia, but all contain calm mineral medicine Cinnabaris of calming the nerves in the former three, can cause certain injury human body.Contain Caulis Polygoni Multiflori in the yangxue anshen pills, take for a long time, its contained anthraquinone analog compound can cause serious liver toxicity.In addition, the prescription of above-mentioned Chinese patent medicine is many mainly to be to regulate at each organ of human body based on nourishing blood to tranquillize the mind, so that therapeutic process is slow.In addition, the existing medicine not operating pressure at most of insomniacs is big, and this cause of disease of nervous anxiety is carried out symptomatic treatment, causes existing medicine all to exist the significant inadequately defective of curative effect.
Summary of the invention
The present invention's technical problem at first to be solved is to overcome existing Chinese medicine and western medicine in the existing deficiency of Cure for insomnia, a kind of new Cure for insomnia, the Chinese medicine composition of anxiety are provided, this Chinese medicine composition has significant relieving stress, calm hypnosis, insomnia, anxiety, anxiety because of operating pressure causes greatly can effectively be alleviated and treat to effects such as nourishing blood to tranquillize the mind; In addition, this Chinese medicine composition had not both had any toxicity, did not have any drug dependence yet.
The present invention's technical problem at first to be solved is achieved through the following technical solutions:
The Chinese medicine composition of a kind of Cure for insomnia, anxiety comprises that each crude drug of following weight portion is made:
Lignum Aquilariae Resinatum 2-4 part, Semen Platycladi 2-5 part, Semen Ziziphi Spinosae 5-8 part, Radix Ophiopogonis 1-4 part and Radix Glycyrrhizae 1-4 part;
Preferably, the weight portion of each crude drug is: 3 parts of Lignum Aquilariae Resinatum, 5 parts of Semen Platycladi, 7 parts of Semen Ziziphi Spinosaes, 3 parts of Radix Ophiopogonis, 2 parts in Radix Glycyrrhizae;
Chinese medicine composition of the present invention is under Chinese medical theory instructs, in conjunction with the achievement in research of modern Chinese medicine pharmacy to insomnia, in conjunction with inventor's clinical practice experience for many years, filter out calm hypnosis, nourishing blood to tranquillize the mind, nourishing YIN and moistening the lung, the crude drug of relieving restlessness clears away heart-fire, according to the theory of Chinese medical science prescription, form according to certain weight prescription.
The compatibility of Chinese medicine composition of the present invention is according to being: the present invention is monarch with the Lignum Aquilariae Resinatum, and Semen Platycladi and Semen Ziziphi Spinosae are minister, and Radix Ophiopogonis is assistant, and Radix Glycyrrhizae is for making; The Lignum Aquilariae Resinatum tranquilizing soporific, spasmolytic; Semen Platycladi, Semen Ziziphi Spinosae nourishing blood to tranquillize the mind, the convergence motive in case dissipate, makes the painstaking effort foot motive flat then refreshing from peaceful; The Radix Ophiopogonis nourishing YIN and moistening the lung, the relieving restlessness that clears away heart-fire, reinforcing stomach reg fluid; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.
The mouse sleep time that Lignum Aquilariae Resinatum extract can make cyclobarbital cause prolongs.Baimuxinic acid contained in the Lignum Aquilariae Resinatum medical material has certain anesthetic action and good analgesic activity to mice.The decocting liquid of Lignum Aquilariae Resinatum has inhibitory action to the autonomous contraction of isolated guinea pig ileum, and the spastic contraction that can cause antihistamine, acetylcholine.The Semen Platycladi alcohol extract can make the S sleep time lengthening of cat, shows that its effective ingredient helps the sleeping of cat, and the sound sleep time is obviously prolonged, and is very remarkable to the antisecosis effect.Semen Ziziphi Spinosae total saponins can reduce spontaneous activity in mice, the time of significant prolongation dosage pentobarbital sodium in mice sleep above threshold, increases the sub-threshold dose pentobarbital sodium sleep number of animals and the length of one's sleep, the mice excitation that the antagonism amfetamine causes.The Semen Ziziphi Spinosae polysaccharide also has the effect of enhancing immunity.Radix Ophiopogonis polysaccharide in the Radix Ophiopogonis all can significantly increase mouse immune organ thymus, spleen weight, and activates the phagocytic function of mice reticuloendothelial system (RES), improves the serum hemolysin antibody horizontal.Glycyrrhizic acid in the Radix Glycyrrhizae has tangible enhance immunity effect.
The used various crude drug of the present invention all can be bought from pharmacy and obtain, and its specification meets country or industry standard gets final product.
Chinese medicine composition of the present invention can be prepared into any acceptable clinically suitable formulations by this area conventional formulation method, for example, can in the active component of medicine of the present invention, add preparation during different dosage form required various adjuvants (for example disintegrating agent, lubricant, adhesive etc.) be prepared into any suitable clinical preparation with the method for Chinese medicinal of routine, for example can be various oral formulations; Wherein, described oral formulations is preferably from tablet, granule, capsule, powder, pill, oral liquid, syrup or drop pill etc.Also Chinese medicine composition of the present invention can be prepared into health promoting wine or non-alcoholic health beverage in addition.
Preferably, a kind of method for preparing above-mentioned Chinese medicine composition, this method may further comprise the steps:
(1) takes by weighing each crude drug by described weight proportion;
(2) each crude drug is mixed the back and add the 40-90% alcohol reflux; Filter, filtrate decompression is concentrated into thick paste;
(3) with the thick paste drying; Add required adjuvant or the excipient of preparations shaping, be prepared into capsule, tablet or pill etc.
In the above-mentioned preparation method, preferred, in the step (2) each crude drug is mixed the back and add 80% alcohol reflux 2 times, extract 60min at every turn; Be 1.10～1.12 thick paste below 60 ℃ filtrate decompression being concentrated into relative density in the step (3);
In addition, also Chinese medicine composition of the present invention can be prepared into health promoting wine or non-alcoholic health beverage, for example, can Chinese medicine composition of the present invention be prepared into reference to following method and have health promoting wine calm, the hypnosis effect:
(1) takes by weighing each crude drug by described weight proportion;
(2) each crude drug mixes back rice wine heating and refluxing extraction; Filter, filtrate in 70 ℃ of high-temperature process 1-3 hours, is cooled off, placement is spent the night, filter, and fill, airtight preservation, promptly.
The toxicity research evidence, Chinese medicine composition of the present invention is without any side effects, does not also have any drug dependence.The clinical observation on the therapeutic effect test shows that Chinese medicine composition of the present invention has significant curative effect for insomnia, anxiety.
Using method and consumption: the dosage of Chinese medicine composition of the present invention depends on factors such as concrete dosage form, patient's age, health status.As guidance: for oral formulations, the consumption of Chinese medicine composition of the present invention is 10-20g crude drug/day, once takes before sleeping every night.
The specific embodiment
Further describe the present invention below in conjunction with specific embodiment, advantage of the present invention and characteristics will be more clear along with description.But these embodiment only are exemplary, scope of the present invention are not constituted any restriction.It will be understood by those skilled in the art that and down can make amendment or replace without departing from the spirit and scope of the present invention, but these modifications and replacing all fall within the scope of protection of the present invention the details of technical solution of the present invention and form.
The preparation of embodiment 1 capsule
Get Lignum Aquilariae Resinatum 300g, Semen Platycladi 500g, Semen Ziziphi Spinosae 700g, Radix Ophiopogonis 300g, Radix Glycyrrhizae 200g.Add 12000ml 80% alcohol reflux 2 times, each 60min.Filter, it is 1.10～1.12 (60 ℃) that filtrate decompression is concentrated into relative density, spray drying; Add an amount of carboxymethylstach sodium, mixing is granulated, the capsule of packing into No. 1, promptly.
The preparation of embodiment 2 tablets
Get Lignum Aquilariae Resinatum 300g, Semen Platycladi 500g, Semen Ziziphi Spinosae 700g, Radix Ophiopogonis 300g, Radix Glycyrrhizae 200g.Reflux, extract, is 2 times in adding 12000ml 40% ethanol, each 60min.Filter, it is 1.10～1.12 (60 ℃) that filtrate decompression is concentrated into relative density, spray drying; Add and an amount of carboxymethylstach sodium, mixing is made tablet.
The preparation of embodiment 3 granules
Get Lignum Aquilariae Resinatum 200g, Semen Platycladi 200g, Semen Ziziphi Spinosae 500g, Radix Ophiopogonis 100g, Radix Glycyrrhizae 100g.Reflux, extract, is 2 times in adding 10000ml 85% ethanol, each 60min.Filter, it is 1.10～1.12 (60 ℃) that filtrate decompression is concentrated into relative density, spray drying; Add and an amount of cane sugar powder and carboxymethylstach sodium, mixing is made granule.
The preparation of embodiment 4 pills
Get Lignum Aquilariae Resinatum 400g, Semen Platycladi 500g, Semen Ziziphi Spinosae 800g, Radix Ophiopogonis 400g, Radix Glycyrrhizae 400g.Reflux, extract, is 2 times in adding 15000ml 80% ethanol, each 60min.Filter, it is 1.10～1.12 (60 ℃) that filtrate decompression is concentrated into relative density, spray drying; Add an amount of pure Oleum sesami or Mel mixing, make pill.
The preparation of embodiment 5 health promoting wine
Get Lignum Aquilariae Resinatum 200g, Semen Platycladi 400g, Semen Ziziphi Spinosae 700g, Radix Ophiopogonis 300g, Radix Glycyrrhizae 200g.Place 12000ml 40 degree rice wine heating and refluxing extraction 2 times, extract 60min at every turn, filter, in 70 ℃ of high-temperature process 2 hours, cooling was spent the night in placing below 8 ℃ with filtrate, filter, and fill, airtight preservation promptly gets health promoting wine.
The preparation of comparative example's 1 drugs compared 1
Get Lignum Aquilariae Resinatum 100g, Semen Platycladi 600g, Semen Ziziphi Spinosae 300g, Radix Ophiopogonis 500g, Radix Glycyrrhizae 400g.Add 12000ml 80% alcohol reflux 2 times, each 60min.Filter, it is 1.10～1.12 (60 ℃) that filtrate decompression is concentrated into relative density, spray drying; Add an amount of carboxymethylstach sodium, mixing is granulated, the capsule of packing into No. 1, promptly.
The preparation of comparative example's 2 drugs compared 2
Get Semen Platycladi 500g, Semen Ziziphi Spinosae 700g, Radix Ophiopogonis 300g, Radix Glycyrrhizae 200g.Add 12000ml 80% alcohol reflux 2 times, each 60min.Filter, it is 1.10～1.12 (60 ℃) that filtrate decompression is concentrated into relative density, spray drying; Add an amount of carboxymethylstach sodium, mixing is granulated, the capsule of packing into No. 1, promptly.
The preparation of comparative example's 3 drugs compared 3
Get Lignum Aquilariae Resinatum 300g, Semen Ziziphi Spinosae 700g, Radix Ophiopogonis 300g, Radix Glycyrrhizae 200g.Add 12000ml 80% alcohol reflux 2 times, each 60min.Filter, it is 1.10～1.12 (60 ℃) that filtrate decompression is concentrated into relative density, spray drying; Add an amount of carboxymethylstach sodium, mixing is granulated, the capsule of packing into No. 1, promptly.
The preparation of comparative example's 4 drugs compared 4
Get Lignum Aquilariae Resinatum 300g, Semen Platycladi 500g, Radix Ophiopogonis 300g, Radix Glycyrrhizae 200g.Add 12000ml 80% alcohol reflux 2 times, each 60min.Filter, it is 1.10～1.12 (60 ℃) that filtrate decompression is concentrated into relative density, spray drying; Add an amount of carboxymethylstach sodium, mixing is granulated, the capsule of packing into No. 1, promptly.
The pharmacodynamics test of test example 1 Chinese medicine composition of the present invention
1, laboratory animal: 160 of Kunming mouses, available from Hainan Medical College's Experimental Animal Center.Male and female half and half, average weight are 20g.
2, experiment grouping: mice is divided into nine groups, be respectively dosetest group in medicine of the present invention (embodiment 1 prepared capsule) the low dosage test group, medicine of the present invention (embodiment 1 prepared capsule), medicine of the present invention (embodiment 1 prepared capsule) high dose test group, drugs compared 1 test group,, drugs compared 2 test group, drugs compared 3 test group, drugs compared 4 test group, positive controls and blank group, every group of male and female half and half.
3, medicine of the present invention is to the influence of mice autonomic activities: the liquid that the basic, normal, high dosage group water of medicine of the present invention (embodiment 1 prepared capsule) is mixed with equal volume, give mouse stomach, dosage is respectively each 2g/Kg, 4g/Kg and 8g/Kg.Positive controls is taken to calm the nerves and is decided the intelligence ball, and dosage is 3g/Kg, 20 times of the dosage of promptly being grown up.The dosage of drugs compared 1 test group, drugs compared 2 test group, drugs compared 3 test group, drugs compared 4 test group is 8g/Kg.Blank group water replaces medicine of the present invention, irritates body of stomach and amasss identical with medicine group of the present invention.Behind the 60min mice is placed toy autonomic activities analyzer, mice autonomic activities number of times in the meter 10min the results are shown in Table 1.As shown in Table 1, can obviously reduce mice autonomic activities number of times behind the medicine group gastric infusion 60min of the present invention.Explanation is in this dosage range, and medicine of the present invention has tangible sedation to mice, and its effect is apparently higher than drugs compared 1 test group, drugs compared 2 test group, drugs compared 3 test group and drugs compared 4 test group.
Table 1 medicine of the present invention is to the influence of mice autonomic activities
| Grouping | Dosage (g/Kg) | Movable number of times in the 10min |
| The blank group | 0 | 168.4±37.1 |
| Medicine low dose group of the present invention | 4 | 131.5±18.8 ** |
| Dosage group in the medicine of the present invention | 6 | 125.4±19.2 ** |
| Medicine high dose group of the present invention | 8 | 121.6±20.3 ** |
| Drugs compared is tested 2 groups | 8 | 151±14.8 * |
| Drugs compared is tested 3 groups | 8 | 152±18.8 ** |
| Drugs compared is tested 4 groups | 8 | 153±15.8 * |
| Drugs compared is tested 1 group | 8 | 142.6±16.8 * |
| Positive controls | 3 | 129.9±20.3 ** |
Annotate:
*P＜0.05,
*Compare with the blank group P＜0.01.
4, medicine of the present invention is to the syngignoscism of subliminal hypnosis dosage pentobarbital sodium mice: get 160 of Kunming mouses, grouping and administration are with 3,60min behind gastric infusion, each treated animal is lumbar injection 30mg/kg pentobarbital sodium respectively, observes to give respectively to organize the sleeping rate of mice (reaching the above person of 1min for sleeping with righting reflex loss) in the 30min behind the pentobarbital sodium.Statistics is respectively organized the sleeping rate of mice, the results are shown in Table 2.As shown in Table 2, medicine of the present invention can obviously increase the sleeping number of mice that the sub-threshold dose pentobarbital sodium causes in this tests used dosage range, remarkable with blank group comparing difference.Illustrate that medicine of the present invention has the maincenter sedative-hypnotic effect to mice, its hypnotic effect obviously be better than drugs compared 1 test group,, drugs compared 2 test group, drugs compared 3 test group and drugs compared 4 test group.
Table 2 medicine of the present invention is to the syngignoscism of subliminal hypnosis dosage pentobarbital sodium mice
| Grouping | Dosage (g/g) | Sleeping mice (only) | Sleeping rate (%) |
| The blank group | 0 | 2 | 10 |
| Low dose group of the present invention | 4 | 14 | 70 |
| Dosage group among the present invention | 6 | 15 | 75 |
| High dose group of the present invention | 8 | 17 | 85 |
| Drugs compared is tested 2 groups | 8 | 13 | 65 |
| Drugs compared is tested 3 groups | 8 | 12 | 60 |
| Drugs compared is tested 4 groups | 8 | 13 | 65 |
| Drugs compared is tested 1 group | 8 | 13 | 65 |
| Positive controls | 3 | 15 | 75 |
5, medicine of the present invention is to the influence of HD pentobarbital sodium mouse sleep time: get 160 of Kunming mouses, grouping and administration are with 3,60min behind gastric infusion, each treated animal is lumbar injection HD pentobarbital sodium 50mg/kg respectively, the observed and recorded animal sleep persistent period (with righting reflex loss to recovering the required time), the results are shown in Table 3.As shown in Table 3, medicine of the present invention can obviously prolong the length of one's sleep of HD pentobarbital sodium mice, relatively there were significant differences with the blank group, and obviously be longer than the length of one's sleep drugs compared 1 test group,, drugs compared 2 test group, drugs compared 3 test group and drugs compared 4 test group.
Table 3 medicine of the present invention is to the influence of HD pentobarbital sodium mouse sleep time
| Grouping | Dosage (g/Kg) | The length of one's sleep (min) |
| The blank group | 0 | 79.1±19.3 |
| Medicine low dose group of the present invention | 4 | 108.5±12.6 ** |
| Dosage group in the medicine of the present invention | 6 | 111.3±11.8 ** |
| Medicine high dose group of the present invention | 8 | 118.3±15.2 ** |
| Drugs compared is tested 2 groups | 8 | 96.2±15.6 * |
| Drugs compared is tested 3 groups | 8 | 95.4±10.6 * |
| Drugs compared is tested 4 groups | 8 | 91.5.±13.8 * |
| Drugs compared is tested 1 group | 8 | 98.4±10.7 * |
| Positive controls | 3 | 112.5±13.4 ** |
Annotate:
*P＜0.05,
*Compare with the blank group P＜0.01.
The explanation of above-mentioned pharmacological tests with the pharmaceutical composition that Lignum Aquilariae Resinatum, Semen Platycladi, Semen Ziziphi Spinosae, Radix Ophiopogonis and Radix Glycyrrhizae compatibility obtain after together, has the pharmacological effect of significant Synergistic between each component; Result of the test also illustrates, with Lignum Aquilariae Resinatum, Semen Platycladi, Semen Ziziphi Spinosae, Radix Ophiopogonis and Radix Glycyrrhizae further according to 2-4: the specified weight proportioning compatibility of 2-5: 5-8: 1-4: the 1-4 resulting pharmaceutical composition in back together has better calmness, hypnotic activity.
The toxicity research test of test example 2 Chinese medicine compositions of the present invention
(1) studies on acute toxicity
Get Kunming mouse, irritate stomach by 10g/kg and give medicine of the present invention (embodiment 1 prepared capsule), successive administration was 4 times in 1 day, and each 6h at interval gives normal diet then, and each organ is carried out the pathologic inspection, does not find organ disease.
(2) long term toxicity research
Get Kunming mouse, in pressing, heavy dose of group (4g/kg, 8g/Kg) irritate stomach and give medicine of the present invention (embodiment 1 prepared capsule), every day 1 time, behind the successive administration 14 days, measure indexs such as mice body weight, cardiac function, liver function, renal function, electrocardiogram, the administration group compares with matched group respectively, shows no obvious abnormalities.Internal organs such as the pathological examination heart, liver,kidney,spleen, lung, stomach, duodenum, large intestine, small intestinal, adrenal gland and genitals, administration group compare with matched group respectively, there is no obvious toxic and change.This Chinese medicine composition safety non-toxic of above results suggest can be used for clinical.
The clinical observation on the therapeutic effect test of test example 3 Chinese medicine compositions of the present invention
One, diagnostic criteria
Relevant 51.0 insomnias (307.4 in China's mental sickness classification schemes and the diagnostic criteria second edition revised edition (CCMD-2-R); F51.0) diagnostic criteria is as follows:
This disease is meant the unsatisfied situation of quality and quantity to sleep that continues the long duration, can not be with the main standard of statistical ortho sleep time as the diagnosis insomnia.There are the worry or the feared state of mind can form vicious cycle to insomnia, thereby make symptom continue to exist.If insomnia is an ingredient of certain mental disorder (as neurasthenia, depression) symptom, be not diagnosed as the insomnia in addition.
(1) be almost only symptom with sleep disorder, other symptoms all are secondary to insomnia, comprise have difficulty in going to sleep, insomnia-middle, easily wake up, the back sense that is difficult for sleeping again, wakes up of dreaminess, early awakening, the back of waking up is uncomfortable, tired or daytime is sleepy.
(2) above-mentioned sleep disorder takes place weekly three times at least, and continues more than one month.
(3) insomnia causes significant worries, or the ergasia decrease in efficiency, or hinders social function.
(4) not the part of any physical disease or mental disorder symptom.
Two, efficacy assessment standard
Carry out efficacy evaluation with reference to " disease of tcm diagnosis criterion of therapeutical effect " middle related content that the State Administration of Traditional Chinese Medicines delivered in 1994.
Cure: insomnia disappears, and the time for falling asleep and the length of one's sleep are normal, and sleeping in promptly 1 hour, the SAN time was above 5 hours.
Produce effects: insomnia makes moderate progress, and the time for falling asleep and the length of one's sleep are normal substantially.
Invalid: insomnia does not have significant change, and the time for falling asleep and the length of one's sleep are undesired.
Three, the experimenter includes standard in
Among the outpatient, 18-55 year is insomniac after diagnosing, and under-18s wherein more than 55 years old, serious primary disease, psychotic, is taken medicine or the food relevant with pharmic function of the present invention in a short time, and influence is to except the judgement person as a result.
Four, grouping
Meet the 300 routine insomnia experimenters that the experimenter includes standard in, be divided into treatment group positive controls and blank group at random, every group 100 example, the men and women half and half, and average course of disease is 1.50 ± 0.7 years.The treatment group is taken medicament capsule of the present invention, and consumption is 10-20g/ day, once takes before sleeping every night.Positive controls is taken commodity medicine mind-easing tonic bolus with arborvitate seed water-honeyed pill, each 1 ball (9g), every day 2 times.The blank group is taken blank placebo, and usage and dosage is with the treatment group.
Five, observation of curative effect
Table 4 sleep quality
| Group | The example number | Average time for falling asleep/min | The average length of one's sleep/h |
| The treatment group | 100 | 20±7* | 7.2±0.2* |
| Positive controls | 100 | 41±6* | 6.7±0.1* |
| The blank group | 100 | 85±5 | 4.6±0.3 |
Compare * P＜0.05 between group
Table 5 cardinal symptom is improved
By table 4 and table 5 as can be known, the average time for falling asleep of treatment group is significantly shorter than positive controls and blank group, significantly is longer than positive controls and blank group the average length of one's sleep.Wherein treatment group patient's clinical symptoms improves significantly, and cure rate is 73%, and total effective rate is 97.5%; The cure rate of positive controls is 67.8%, and total effective rate is 95.5%; The cure rate of blank group is 0, and total effective rate is 3.7%.
The clinical observation on the therapeutic effect test shows that Chinese medicine composition of the present invention has significant therapeutic efficiency for the insomnia.
Claims (10)
1. the Chinese medicine composition of a Cure for insomnia, anxiety is made by each crude drug of following weight portion: Lignum Aquilariae Resinatum 2-4 part, Semen Platycladi 2-5 part, Semen Ziziphi Spinosae 5-8 part, Radix Ophiopogonis 1-4 part and Radix Glycyrrhizae 1-4 part.
2. according to the described Chinese medicine composition of claim 1, it is characterized in that the weight portion of each crude drug is: 3 parts of Lignum Aquilariae Resinatum, 5 parts of Semen Platycladi, 7 parts of Semen Ziziphi Spinosaes, 3 parts of Radix Ophiopogonis, 2 parts in Radix Glycyrrhizae.
3. according to claim 1 or 2 described Chinese medicine compositions, it is characterized in that: this Chinese medicine composition is any acceptable clinically suitable formulations.
4. according to the described Chinese medicine composition of claim 3, it is characterized in that: described preparation is an oral formulations.
5. according to the described Chinese medicine composition of claim 4, it is characterized in that: described oral formulations is tablet, granule, capsule, powder, pill or oral liquid.
6. according to claim 1 or 2 described Chinese medicine compositions, it is characterized in that: this Chinese medicine composition is prepared into health promoting wine or non-alcoholic beverages.
7. one kind prepares the oral formulations of claim 1 or 2 described Chinese medicine compositions or the method for non-alcoholic beverages, and this method may further comprise the steps:
(1) takes by weighing each crude drug by described weight proportion;
(2) each crude drug is mixed the back and add the 40-90% alcohol reflux; Filter, filtrate decompression is concentrated into thick paste;
(3) with the thick paste drying, add required adjuvant or the excipient of preparations shaping, preparations shaping, promptly.
8. in accordance with the method for claim 7, it is characterized in that: in the step (2) each crude drug is mixed the back and add 80% alcohol reflux 2 times, extract 60min at every turn; Be 1.10～1.12 thick paste below 60 ℃ filtrate decompression being concentrated into relative density in the step (2).
9. a method for preparing the described health promoting wine of claim 6 is characterized in that, may further comprise the steps:
(1) takes by weighing each crude drug by described weight proportion;
(2) each crude drug mixes back rice wine heating and refluxing extraction; Filter, filtrate in 70 ℃ of high-temperature process 1-3 hours, is cooled off, placement is spent the night, filter, and fill, airtight preservation, promptly.
10. claim 1 or the 2 described Chinese medicine compositions purposes in preparation hypnosis or calm medicine.
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