CN101461930B - Medicament for treating children's diarrhea - Google Patents
Medicament for treating children's diarrhea Download PDFInfo
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- CN101461930B CN101461930B CN2008102387653A CN200810238765A CN101461930B CN 101461930 B CN101461930 B CN 101461930B CN 2008102387653 A CN2008102387653 A CN 2008102387653A CN 200810238765 A CN200810238765 A CN 200810238765A CN 101461930 B CN101461930 B CN 101461930B
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Abstract
The invention discloses a drug for treating infantile diarrhea and belongs to the field of traditional Chinese medicine. The drug is characterized by being prepared from poria, Rhizoma Atractylodis Macrocephalae, Pericarpium Arecae, Semen Plantaginis, Radix Puerariae, Pinelliae Tuber and ginger according to certain weight. The drug is combined according to Chinese pharmacopoeia and pharmacology with reference to the national medical recognition of the etiopathology of the infantile diarrhea and valuable treatment experience, the prior reasonable formulas and treatment with syndrome differentiation, is innovative and improved and can effectively treat infantile acute and chronic diarrhea, dysentery, thirst but no desire for drinking water, difficulty in micturition, abdominal swelling and nausea and vomiting. The drug is a pure traditional Chinese medical preparation, scientific and reasonable in combination, free from toxic and side effects, convenient to take, and high in cure rate and total effective rate.
Description
Technical field
The invention belongs to the field of Chinese medicines, the acute and chronic diarrheal Chinese medicine preparation of particularly a kind of treatment children's.
Background technology
Infantile diarrhea is mainly in infant, is divided into acute and chronic two kinds, and severe patient is referred to as dysentery, belongs to the category that Chinese medicine is had loose bowels, and all can take place throughout the year, to see autumn more.Its sick position is mainly at taste and intestine and small intestine, and weakness of the spleen and stomach own adds injury due to diet, experience due to the exopathogen such as cold-damp summer-heat, but main key is the spleen and stomach function obstacle, exopathogenic factor and damp concern maximum, positive so-called domination of damp pathogen is then let out.Taste are impaired, and dysfunction of the spleen in transportation and transformation is experienced damp, water occurs and annotate between intestinal, or let out or rush down symptoms such as oliguria.And see feeling thirst but no desire to drink, dysuria, abdominal part distension, symptoms such as nausea and vomiting more.
Western medicine thinks that 80% children's infection is caused that by virus institute rotavirus is a main pathogen.Other causes of disease also have bacterial infection, parasitic infection and fungal infection, mainly are because the toxin of virus, antibacterial and generation thereof to the damage of intestinal mucosa, makes the absorption and the secretory function generation obstacle of Water-Electrolyte, due to large quantity of moisture rests in the enteric cavity.Western medical treatment is based on antiviral drugs clinically at present, and its treatment measure mainly contains: (1) replenishes trace element and vitamin such as zinc, ferrum, vitamin PP, A, C, B1, B12 and folic acid; (2) intestinal mucosa such as montmorillonite powder protection medicine; (3) little ecological preparation or flora regulator regulated such as bacillus bifidus, bacillus acidophilus and streptococcus faecalis.Medicine mainly contains five dimension Portugal calcium, dioctahedral smectite, golden bifid or Medilac-Vita.Clinical trial proves that the curative effect of western medical treatment clinical practice is not really definite, and price is higher, and side effect is bigger.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of infantile diarrhea, pure Chinese medicinal preparation has no side effect, the cure rate height.
The present invention is achieved in that
The medicine of treatment infantile diarrhea is characterized in that the component of making effective ingredient by its weight proportion is: Poria 8-15, Rhizoma Atractylodis Macrocephalae 8-15, Pericarpium Arecae 8-15, Semen Plantaginis 8-15, Radix Puerariae 8-15, Rhizoma Pinelliae 2-8 and Rhizoma Zingiberis Recens 1-5.
Chinese medicine thinks that the treatment infantile diarrhea should be a method with invigorating the spleen and benefiting QI, dampness removing and diarrhea-relieving, and the pathogenesis that can hit, the famous doctor family of Ming Dynasty Zhang Jingyue just propose the diagnosis of " control and let out not diuresis, Fei Qizhi also ".The present invention is with reference to the invaluable experience of motherland's medical science to pathogenetic understanding of infantile diarrhea and treatment, consult existing reasonable formula, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs is according to Chinese Pharmacopoeia and pharmacology compatibility, pushing away Chen Zhixin and gain to some extent, is the successful medicine for traditional medicine treatment infantile diarrhea.Can effectively treat the acute and chronic diarrhoea of children's, dysentery, and see feeling thirst but no desire to drink, dysuria, abdominal part distension, nausea and vomiting person.The present invention has following clinical effectiveness:
One, prescription medical material choice materials meet and according to Chinese Pharmacopoeia and pharmacology compatibility, abide by ancient the process of preparing Chinese medicine, and compatibility is proper, cooperates scientific and reasonable;
Two, pure Chinese medicinal preparation has no side effect, taking convenience;
Three, cure rate height.Empirical tests, cure rate of the present invention is up to 82%, and total effective rate reaches 93%.
Pharmacology analysis
Modern pharmacological research proves:
1, Poria
Sweet providing additional supplies oozed, and property is flat, and effect is gentle, and no cold and heat are partially, so the available various edema of cold and heat and asthenia and sthenia of controlling.Contain pachyman, pachymic acid, protein, fat, lecithin, choline, histidine, ergosterol etc.Diuresis is arranged, can increase electrolytical discharges such as potassium, sodium, chlorine in the urine.
2, the Rhizoma Atractylodis Macrocephalae
Contain volatile oil, main component is an atractylone in the oil, atractylodes lactone A, B and saccharide (being mainly mannose, fructose) etc.Strong, diuresis, blood sugar lowering, anticoagulant effect are arranged, and can the liver protecting.
3, Pericarpium Arecae
Contain arecoline and arecaidine etc., can excited gastrointestinal tract.
4, Semen Plantaginis
Many mucous matter, succinic acid, Herba Plantaginis enol, adenine, choline, Semen Plantaginis alkali, fatty oil, vitamin A and B etc. have remarkable diuresis.
5, Radix Puerariae
Mainly contain Flavonoid substances: big legumin, daidzin, also have big legumin-4,7-diglucoside, puerarin, 7-xyloside, Radix Puerariae alcohol, Radix Puerariae rattan element and daidzin and starch.Daidzin has obvious spasmolysis to the mice intestine in vitro, can be to the intestinal tube spasm due to the anti-acetylcholine.
6, the Rhizoma Pinelliae
Contain cupreol and glycoside, several amino acids and volatile oil, Saponin, the acidity alcohols, choline, alkaloid such as sanedrine and little fat, starch etc. can suppress vomiting center and preventing or arresting vomiting.
7, Rhizoma Zingiberis Recens
Contain volatile oil, be mainly zingiberol, zingiberene, phellandrene, citral, aromatic alcohol, methyl heptenone, aldehyde C-9, α-Borneolum Syntheticum etc. in the oil, still contain the pungency component gingerol.The secretion of facilitating digestion liquid is arranged, promote diet, effect is told in the town.
Theory of Chinese medical science is thought: insufficiency of the spleen leading to overabundance of dampness, disease are had loose bowels or dysentery, and insufficiency of the spleen fortuneization is too late, inability of body fluid to function, on can not on hold in mouth so see thirstyly, the water channel that can not become down down is so dysuria, water is wet gather in Jiao's abdominal distention then, the pathogenic water superinverse is then felt sick.Poria is monarch in the side, the promoting diuresis to eliminate damp pathogen spleen invigorating; The Rhizoma Atractylodis Macrocephalae is a minister, and auxiliary Poria strengthens the function of air making-up and spleen enlivening, and energy dampness diuretic; Assistant strengthens the effect of inducing diuresis to remove edema, eliminating dampness by diuresis antidiarrheal, inducing diuresis for treating stranguria syndrome with Pericarpium Arecae, Semen Plantaginis; Radix Puerariae is assistant, but both yang invigorating antidiarrheal, again can promoting the production of body fluid to quench thirst; The Rhizoma Pinelliae, Rhizoma Zingiberis Recens are also for assistant, with stopping nausea and vomiting by lowering the adverse flow of QI.
Discover by experiment, originally can make the water damp poison that is stranded in the intestinal change its course goes from urine, can promote simultaneously the recovery of the intestinal absorption and the function of motion again, help enteric cavity to water, electrolytical absorption, reduce the enteric cavity osmotic pressure, reduce the secretion of intestinal juice, strengthen the role of correcting of fluid replacement therapy dehydration, mistake electrolyte, acid base imbalance.Facilitating digestion liquid secretion is arranged simultaneously, promote diet, effect is told in the town, it is evident in efficacy therefore to treat infantile diarrhea.
The specific embodiment
Below in conjunction with embodiment the present invention is elaborated.
Embodiment 1
1. the side's of getting Chinese medicine Poria 10g, Rhizoma Atractylodis Macrocephalae 10g, Pericarpium Arecae 10g, Semen Plantaginis 10g, Radix Puerariae 10g, Rhizoma Pinelliae 5g, Rhizoma Zingiberis Recens 3g.Poria 10g Rhizoma Atractylodis Macrocephalae 10g Pericarpium Arecae 10g Semen Plantaginis 10g Radix Puerariae 10g Rhizoma Pinelliae 5g Rhizoma Zingiberis Recens 3g soaks half an hour, hot digestion 1.5 hours, and it is stand-by to get filtrate.
2. residue added the water steaming and decocting 1 hour again after the steaming and decocting, got filtrate.
3. merge twice and get filtrate, promptly get medicine of the present invention.Oral: every day 2 times, every day 10-30ml.
Using method:
The present invention can be prepared into oral liquid formulation, can also be prepared into powder, pill, electuary, capsule and unguentum according to a conventional method, also can get the above-mentioned raw materials medicine and take as Chinese herbs decoction by proportioning.
Embodiment 2
Divide and get Poria 8g, Rhizoma Atractylodis Macrocephalae 15g, Pericarpium Arecae 8g, Semen Plantaginis 15g, Radix Puerariae 8g, Rhizoma Pinelliae 8g, Rhizoma Zingiberis Recens 1g.Manufacture method and instructions of taking can effectively be treated the acute and chronic diarrhoea of children's with embodiment 1.
Embodiment 3
Divide and get Poria 15g, Rhizoma Atractylodis Macrocephalae 8g, Pericarpium Arecae 15g, Semen Plantaginis 8g, Radix Puerariae 15g, Rhizoma Pinelliae 2g, Rhizoma Zingiberis Recens 5g.Manufacture method and instructions of taking also can effectively be treated the acute and chronic diarrhoea of children's with embodiment 1.
Clinical trial
Be the curative effect of checking medicine of the present invention, the applicant carried out following clinical trial in 2005-2008 at Shandong Province's Liaocheng City the People's Hospital Pediatrics Department:
One, clinical data
(1) test acute and chronic diarrhea patient 200 examples of children's altogether, wherein women 70 examples, male 130 examples, the age is between June-2 years old.
(2) above-mentioned patient is divided into two groups at random:
First group is the treatment group, totally 100 examples, wherein women 40 examples, male 60 examples;
Second group is matched group, its 100 example, wherein women 30 examples, male 70 examples.
Two, diagnostic criteria
According to " practical department of pediatrics diagnosis and treatment standard " infantile diarrhea diagnostic criteria, in vain as the main foundation of spleen-deficient typing, all the patient all is diagnosed as the infantile diarrhea patient with the pale tongue tongue fur.
Three, Therapeutic Method
Oral medicine water decoction of the present invention is organized in treatment, and every day, potion divided secondary to take.
Oral golden bifid 0.5 gram of matched group, every day 3 times.
Four, therapeutic evaluation standard
According to " subproposal of diarrhoeal diseases curative effect judging standard " of the whole nation, Beijing in 1998 organizing committee of diarrhoeal diseases control scientific seminar revision, formulate following therapeutic evaluation standard:
Cure: treat in 2 days, the diarrhoea number of times reduces in 3 times, diarrhoea total amount＜150ml; Feces shape and number of times recover normal in 3 days, and General Symptoms disappears.
Effectively: in the medication 2 days, the diarrhoea number of times reduces in 5 times, diarrhoea total amount＜250ml; Feces shape and number of times are clearly better in 3 days, and General Symptoms obviously improves.
Invalid: after the medication in 2 days, the diarrhoea number of times is still more than 5 times, diarrhoea total amount＞300ml, and feces shape, number of times and General Symptoms all do not have being clearly better even worsen in 3 days.
Five, curative effect
Statistical method: the t check is adopted in the contrast of before the treatment and treatment back measurement data, and the X2 check is adopted in percentile contrast.
Efficacy result sees the following form:
Table 1
| Group | Total treatment (people) | Cure (people) | Effectively (people) | Invalid (people) | Total effective rate |
| The treatment group | 100 | 82 | 11 | 7 | 93％ |
| Matched group | 100 | 77 | 13 | 10 | 90％ |
Two groups of total effective rates compare=8.35, P＜0.05, and difference has highly significant.
Result: treatment group obvious effective rate 82% (82/100), total effective rate 93% (93/100).
Matched group obvious effective rate 77% (77/100), total effective rate 90% (90/100).
2 groups of antidiarrheal times and total course of treatment see the following form after the medication:
Table 2
| Group | Total treatment (people) | The average antidiarrheal time (my god) | Average total treatment time (my god) |
| The treatment group | 100 | 2.16±0.81 | 5.46±1.30 |
| Matched group | 100 | 3.85±2.51 | 7.68±1.84 |
| t | 6.77 | 10.52 | |
| p | ＜0.01 | ＜0.01 |
Six, conclusion
Above clinical trial proves that medicine of the present invention has tangible curative effect, cure rate, total effective rate height for the acute and chronic diarrhoea of treatment children's.And do not see any untoward reaction in the medication process.
Seven, concrete case
Case 1, male, 15 months
Autumn, morbidity was suffered from diarrhoea 2 days, increased the weight of my institute over 1 day.Suffer from diarrhoea 6～7 times/day, the diarrhoea amount is many, defecates to be yellow rare watery stool, and the urine amount is few, once 2 vomitings.Have a medical check-up: 37.3 ℃ of body temperature, to grow normally, nutrition is general, the eye socket depression, lip is done, and neck is soft, and two pulmonary respiration sounds are clear, hear and rale, and hear sounds is strong, 96 times/min of heart rate, the rhythm of the heart is neat, and abdomen is soft, and the liver spleen does not touch, and bowel sounds active, limb end are cold slightly.Skin elasticity is poor.Pale and moist tongue, thin white fur of tongue.Be diagnosed as infantile diarrhea, income gives medicine of the present invention in hospital, and usefulness is decocted in water for oral dose.Took medicine 2 days, the state of an illness is clearly better, and suffers from diarrhoea 3 times/day, is yellow loose stool, and amount is few, and the urine amount is normal.Continued to take medicine 2 days, and do not have diarrhoea, recovery from illness is left hospital.
Case 2: women, 18 months.
Examine over 1 day because of vomiting, diarrhoea, vomitus is a gastric content, defecates 4-5 time on the one, is the egg style just, and the urine amount does not have obvious minimizing.Have a medical check-up: ordinary circumstance still can, breathe flat, skin elasticity still can, lip is slightly done, two pulmonary respiration sounds are clear, cardiac auscultation is no abnormal, abdomen is soft, does not have and touches a tender spot, liver does not touch, stool routine examination microscopy feminine gender is examined and is " rotavirus enteritis ".Give the present invention and boil medicine one pair, divide 2 times oral, tell next day and end, stool character takes a turn for the better, and serve on 3 days, transference cure, stool is shaped.Cure.
Case 3: male, 6 months.
Because of heating, diarrhoea were examined over 2 days.38 ℃ of body temperature, rare water just, surplus one day 10 time, hypourocrinia.Have a medical check-up: listless, mind is clear, the mild dehydration looks, and thin white fur of tongue, pharyngeal congestion, two pulmonary respiration are thick, no rale, hear sounds is strong, and heart rate 110 times/minute is just being restrained, abdominal tympanites flatulence, liver, spleen do not touch.Routine blood test: leukocyte 6.0 * 10
9/ L, N35%, L65%, stool routine examination feminine gender.Examine and be viral enteritis.Give medicine of the present invention and fry in shallow oil Tang Yifu, divide 2 times oral, viral enteritis takes a turn for the better, the same day, heat was moved back, spirit takes a turn for the better, and takes 3 days, stool is normal.Cure.
Claims (2)
1. the medicine of treatment infantile diarrhea is characterized in that the component of making effective ingredient by its weight proportion is: Poria 8-15, Rhizoma Atractylodis Macrocephalae 8-15, Pericarpium Arecae 8-15, Semen Plantaginis 8-15, Radix Puerariae 8-15, Rhizoma Pinelliae 2-8 and Rhizoma Zingiberis Recens 1-5.
2. the medicine of treatment infantile diarrhea according to claim 1 is characterized in that the weight proportion of said components is: Poria 10, the Rhizoma Atractylodis Macrocephalae 10, Pericarpium Arecae 10, Semen Plantaginis 10, Radix Puerariae 10, the Rhizoma Pinelliae 5 and Rhizoma Zingiberis Recens 3.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008102387653A CN101461930B (en) | 2008-12-23 | 2008-12-23 | Medicament for treating children's diarrhea |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008102387653A CN101461930B (en) | 2008-12-23 | 2008-12-23 | Medicament for treating children's diarrhea |
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| CN101461930B true CN101461930B (en) | 2010-06-30 |
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Families Citing this family (1)
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| CN104815300B (en) * | 2015-03-12 | 2018-08-10 | 天峨县平昌生态农业有限公司 | A kind of Antidiarrheal Chinese medicine cream and preparation method thereof and application method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1435202A (en) * | 2002-01-27 | 2003-08-13 | 武水庆 | Medicine for treating child diarrhea |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1435202A (en) * | 2002-01-27 | 2003-08-13 | 武水庆 | Medicine for treating child diarrhea |
Non-Patent Citations (4)
| Title |
|---|
| 李淑秋.小儿腹泻.中国社区医师.1988, |
| 李淑秋.小儿腹泻.中国社区医师.1988. * |
| 赵藏朵,张继红,张惠玲.针药结合治疗小儿秋季腹泻100例.陕西中医.2005,(12), |
| 赵藏朵,张继红,张惠玲.针药结合治疗小儿秋季腹泻100例.陕西中医.2005,(12). * |
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