CN107970295A - A kind of pharmaceutical composition to relax bowel, preparation and preparation method thereof - Google Patents
A kind of pharmaceutical composition to relax bowel, preparation and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
A kind of pharmaceutical composition to relax bowel, preparation and preparation method thereof, are related to technical field of pharmaceuticals.A kind of pharmaceutical composition to relax bowel, pharmaceutical composition count in parts by weight including：3 10 parts of 10 15 parts of fructus cannabis, 2 10 parts of radix glycyrrhizae, 9 15 parts of Semen Lablab Album, 9 15 parts of cassia seed, 5 10 parts of almond, 9 15 parts of Siraitia grosvenorii, 5 10 parts of peach kernel, 9 15 parts of mulberries, 5 12 parts of radish seed, 9 15 parts of Semen sesami nigrum, 6 10 parts of brush-cherry seed and purple perilla.The pharmaceutical composition has effects that preferably to relax bowel, and has therapeutic effect well to constipation.
Description
Technical field
The present invention relates to technical field of pharmaceuticals, and the more particularly to a kind of pharmaceutical composition to relax bowel, preparation and its system
Preparation Method.
Background technology
Constipation is clinical common symptom, is primarily referred to as that few defecation frequency, difficult defecation, laborious, defecation be not smooth, stool is dry
Knot, defecation be not net, defecation is with abdominal pain etc..The functional property side of constipation touch with organic two kinds of constipation, constipation often causes people's feelings
Thread changes, and upsets, and notice laxes, and influences daily life and work, and rectitis, the stifled, anal fissure of intestines stalk etc. can be caused more
Kind complication.
The content of the invention
The first purpose of the purpose of the present invention is to provide a kind of pharmaceutical composition to relax bowel, which has
Preferable the effect of relaxing bowel, have therapeutic effect well to constipation.
The second object of the present invention is to provide a kind of pharmaceutical preparation to relax bowel.
The third object of the present invention is to provide a kind of preparation method of the pharmaceutical preparation to relax bowel, preparation method letter
Single, obtained pharmaceutical preparation quality is high, good drug efficacy.
The present invention is solved its technical problem and is realized using following technical scheme.
The present invention proposes a kind of pharmaceutical composition to relax bowel, pharmaceutical composition count in parts by weight including：
10-15 parts of fructus cannabis, 2-10 parts of radix glycyrrhizae, 9-15 parts of Semen Lablab Album, 9-15 parts of cassia seed, 5-10 parts of almond, Siraitia grosvenorii
9-15 parts, 5-10 parts of peach kernel, 9-15 parts of mulberries, 5-12 parts of radish seed, 9-15 parts of Semen sesami nigrum, 6-10 parts of brush-cherry seed and purple perilla 3-
10 parts.
A kind of pharmaceutical preparation to relax bowel, it is by the above-mentioned pharmaceutical composition to relax bowel and pharmaceutically acceptable
Auxiliary material forms.
A kind of pharmaceutical preparation to relax bowel, it is made of the above-mentioned pharmaceutical composition to relax bowel fermentation.
A kind of above-mentioned pharmaceutical preparation to relax bowel, including：Count in parts by weight, by fructus cannabis, radix glycyrrhizae, Semen Lablab Album,
Cassia seed, almond, Siraitia grosvenorii, peach kernel, mulberries, radish seed, Semen sesami nigrum, brush-cherry seed and purple perilla are mixed to get mixture, will mix
After thing ferments at a temperature of 80-100 DEG C after being mixed with water and probiotics, pharmaceutical solutions are obtained by filtration.
A kind of preparation method of the pharmaceutical preparation to relax bowel, it includes：
By fructus cannabis 10-15 parts by weight, radix glycyrrhizae 2-10 parts by weight, Semen Lablab Album 9-15 parts by weight, cassia seed 9-15 parts by weight,
Siraitia grosvenorii 9-15 parts by weight, peach kernel 5-10 parts by weight, mulberries 9-15 parts by weight, radish seed 5-12 parts by weight, Semen sesami nigrum 9-15 weights
Part, brush-cherry seed 6-10 parts by weight and the mixing of purple perilla 3-10 parts by weight are measured, according to solid-liquid ratio 1:5~8 are blended in 90-100 with water
DEG C temperature conditionss under decoct 15-25min after, add almond 5-10 parts by weight continue to filter after 10~15min of decoction first
Filtrate and filter residue, mix 15~25min of decoction with water by filter residue and obtain the second filtrate, the first filtrate and the second filtrate are mixed
To liquid, liquid is concentrated to give medicinal extract.
The beneficial effect of the embodiment of the present invention is：The pharmaceutical composition disclosed by the invention to relax bowel, by fructus cannabis, sweet
Grass, Semen Lablab Album, cassia seed, almond, Siraitia grosvenorii, peach kernel, mulberries, radish seed, Semen sesami nigrum, brush-cherry seed and purple perilla are by suitable proportioning
Composition.The pharmaceutical composition is drafted according to theory of traditional Chinese medical science, from invigorating the spleen and benefiting qi, promote the production of body fluid to quench thirst, help digestion and eliminate flatulence, relax bowel this four
Aspect drug combination, can effectively treat constipation.And the pharmaceutical composition is gentle, does not stimulate, good drug efficacy.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer, is the conventional production that can be obtained by commercially available purchase
Product.
A kind of logical intestines profit of embodiment of the present invention pharmaceutical composition just, pharmaceutical preparation and preparation method thereof are carried out below
Illustrate.
A kind of pharmaceutical composition to relax bowel, pharmaceutical composition count in parts by weight including：
10-15 parts of fructus cannabis, 2-10 parts of radix glycyrrhizae, 9-15 parts of Semen Lablab Album, 9-15 parts of cassia seed, 5-10 parts of almond, Siraitia grosvenorii
9-15 parts, 5-10 parts of peach kernel, 9-15 parts of mulberries, 5-12 parts of radish seed, 9-15 parts of Semen sesami nigrum, 6-10 parts of brush-cherry seed and purple perilla 3-
10 parts.
In some embodiments, count in parts by weight, fructus cannabis is 11-14 parts, radix glycyrrhizae is 3-8 parts, Semen Lablab Album 10-
14 parts, cassia seed be 10-14 parts, almond is 6-9 parts, Siraitia grosvenorii is 10-14 parts, peach kernel is 6-9 parts, mulberries are 10-14 parts, Lay
Fu is 6-10 parts, Semen sesami nigrum is 10-14 parts, brush-cherry seed is 7-9 parts, purple perilla is 4-8 parts.
In some embodiments, count in parts by weight, fructus cannabis is 12-13 parts, radix glycyrrhizae is 4-6 parts, Semen Lablab Album 11-
13 parts, cassia seed be 11-13 parts, almond is 7-8 parts, Siraitia grosvenorii is 11-13 parts, peach kernel is 7-8 parts, mulberries are 11-13 parts, Lay
Fu is 7-9 parts, Semen sesami nigrum is 11-13 parts, brush-cherry seed is 8-9 parts, purple perilla is 5-6 parts.
Fructus cannabis, it is sweet in flavor, it is mild-natured；Returns spleen, stomach, large intestine channel.It has effects that to relax bowel.
Radix glycyrrhizae, it is sweet in flavor, it is mild-natured；The thoughts of returning home, lung, spleen, stomach.It, which has, invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, emergency
The effect of analgesic, coordinating the drug actions of a prescription.It can be used for weakness of the spleen and the stomach, lassitude hypodynamia, and palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction are anxious
Pain, carbuncle sore tumefacting virus, alleviate drug toxicity, strong.
Semen Lablab Album, sweet in flavor, slightly warm in nature.Returns spleen, stomach.It has effects that invigorating the spleen for eliminating dampness, inducing diuresis to remove edema and in relieve summer heat.
It can be used for weakness of the spleen and the stomach, loss of appetite, diarrhea, leukorrhea, summer-heat and damp vomiting and diarrhoea, abdominal distension uncomfortable in chest.It is good in addition, frying Semen Lablab Album
Spleen dampness elimination.For splenasthenic diarrhea, leukorrhea.
Cassia seed, sweet in flavor, bitter, salty, cold nature.Return liver, large intestine channel.It has effects that to relax bowel, heat-clearing improving eyesight.Its
Available for the puckery pain of hot eyes, the more tears of photophobia, dizziness of having a headache, mesh is secretly unknown, constipation.
Almond, bitter, slightly warm in nature；Return lung, large intestine channel.It has effects that to relax bowel, is relieving cough and asthma.It can be used for cough
Cough asthma, fullness sensation in chest abundant expectoration, dry constipation of intestines.
Siraitia grosvenorii, it is sweet in flavor, it is cool in nature；Return lung, large intestine channel.It has effects that laxation defaecation, clearing heat and moistening lung, cough-relieving relieving sore-throat.
For lung-fire cough caused by dryness, pharyngalgia aphonia, dry constipation of intestines.
Peach kernel, bitter but sweet flavor are mild-natured.The thoughts of returning home, liver, large intestine, lung, the spleen channel.It is with promoting blood circulation, the effect of relaxing bowel.
It can be used for Amenorrhea, dysmenorrhoea , wei lump in the abdomen lump in the abdomens, injury from falling down, dry constipation of intestines.Pyreticosis stores blood, wandering arthritis, malaria, hemotoncus pain.
Mulberries, it is sweet in flavor, sour, it is cold in nature.Return liver and kidney channel.It has effects that to promote the production of body fluid to quench thirst, promotes digestion, helps defecation.Its
Have a dizzy spell available for what kidney deficiency and liver and deficiency of blood essence lost；Soreness of waist tinnitus；Poliosis；Insomnia and dreamful sleep；Injury thirst；Quench one's thirst；
Dry constipation of intestines.
Radish seed, it is acrid flavour, sweet, it is mild-natured.Return lung, spleen, stomach.With help digestion and eliminate flatulence, the effect of lowering the adverse-rising QI to resolve phlegm.It can be used for
Retention of food and drink, abdominal distention, constipation, stagnate rush down dysentery, and phlegm, which is stopped up, breathes with cough.
Semen sesami nigrum, it is sweet in flavor, it is mild-natured.Return liver, kidney, large intestine channel.With filling liver kidney, benefiting essence-blood, the dry effect of ease constipation.It is available
In dizzy, Hiccough and deaf, poliosis, post disease alopecia, dry constipation of intestines.
Brush-cherry seed, it is acrid flavour, hardship, sweet, it is mild-natured.Returns spleen, large intestine, small intestinl channel.With relaxing bowel, the effect of lower gas profit water.
It can be used for intestine-dryness due to consumption of fluid, stagnation of QI due to dyspepsia, abdominal distention constipation, oedema, tinea pedis, difficult urination.
Purple perilla, acrid flavour are warm-natured.It is distributed in lung channel.It is relieving cough and asthma with lowering the adverse-rising QI to resolve phlegm, the effect of relaxing bowel.It can be used for
Phlegm stops up the circulation of vital energy in the wrong direction, cough and asthma, dry constipation of intestines.
The pharmaceutical composition disclosed by the invention to relax bowel, by fructus cannabis, radix glycyrrhizae, Semen Lablab Album, cassia seed, almond, sieve
Chinese fruit, peach kernel, mulberries, radish seed, Semen sesami nigrum, brush-cherry seed and purple perilla are formed by suitable proportioning.The pharmaceutical composition is in
Medical knowledge opinion is drafted, from invigorate the spleen and benefit qi, promote the production of body fluid to quench thirst, help digestion and eliminate flatulence, relax bowel drug combination in terms of this four, promote the production of body fluid to quench thirst meaning
Taste, which, first to be digested food in the oral cavity, is preferably digested food in stomach by help digestion and eliminate flatulence, passes through tonifying spleen benefit
Gas increases digestion of the taste to food, and gas can increase the wriggling ability of stomach completely so that stool is easily drained, along with ease constipation
Defaecation can be beneficial to the discharge of stool.The pharmaceutical composition is gentle, does not stimulate, and can effectively treat constipation.
Inventor's research shows, which is suitable for that awareness of defecation is few, bowel frequency is also few, defecation is difficult, laborious, defecation not
Freely, dry and hard excrement, it is hard just, defecation not only sense, constipation with symptoms such as abdominal pain or abdominal discomforts.
A kind of pharmaceutical preparation to relax bowel, it is by the above-mentioned pharmaceutical composition to relax bowel and pharmaceutically acceptable
Auxiliary material forms.
Further, the formulation of pharmaceutical preparation includes pill or tablet.These formulations are that Chinese medicine or Chinese patent drug are common
Formulation.
A kind of pharmaceutical preparation to relax bowel, it is made of the above-mentioned pharmaceutical composition to relax bowel fermentation.
The preparation method of the pharmaceutical preparation to relax bowel, including：Count in parts by weight, by fructus cannabis, radix glycyrrhizae, Semen Lablab Album,
Cassia seed, almond, Siraitia grosvenorii, peach kernel, mulberries, radish seed, Semen sesami nigrum, brush-cherry seed and purple perilla are mixed to get mixture, will mix
After thing ferments at a temperature of 80-100 DEG C after being mixed with water and probiotics, pharmaceutical solutions are obtained by filtration.
The preparation method of the pharmaceutical preparation, the active ingredient of pharmaceutical composition are converted by probiotics, become by macromolecular
Small molecule, can human body preferably absorb, drug effect is more preferable, and curative effect is faster.In fermentation process, medicine reduces medicine by conversion
The detrimental toxicities of thing, improve the bitter taste of Chinese medicine.
Present embodiment also provides a kind of preparation method of the pharmaceutical preparation to relax bowel, it includes：
By fructus cannabis 10-15 parts by weight, radix glycyrrhizae 2-10 parts by weight, Semen Lablab Album 9-15 parts by weight, cassia seed 9-15 parts by weight,
Siraitia grosvenorii 9-15 parts by weight, peach kernel 5-10 parts by weight, mulberries 9-15 parts by weight, radish seed 5-12 parts by weight, Semen sesami nigrum 9-15 weights
Part, brush-cherry seed 6-10 parts by weight and the mixing of purple perilla 3-10 parts by weight are measured, according to solid-liquid ratio 1:5~8 are blended in 90-100 with water
DEG C temperature conditionss under decoct 15-25min after, add almond 5-10 parts by weight continue to filter after 10~15min of decoction first
Filtrate and filter residue, mix 15~25min of decoction with water by filter residue and obtain the second filtrate, the first filtrate and the second filtrate are mixed
To liquid, liquid is concentrated to give medicinal extract.It should be noted that the material in solid-liquid ratio refers to pharmaceutical composition each component
The amount of summation, liquid refer to the amount of water.
Alternatively, count in parts by weight, fructus cannabis is 11-14 parts, radix glycyrrhizae is 3-8 parts, Semen Lablab Album is 10-14 parts, Cassia
Son is 10-14 parts, almond is 6-9 parts, Siraitia grosvenorii is 10-14 parts, peach kernel is 6-9 parts, mulberries are 10-14 parts, radish seed 6-
10 parts, Semen sesami nigrum be 10-14 parts, brush-cherry seed is 7-9 parts, purple perilla is 4-8 parts.
Further, relative density of the medicinal extract at a temperature of 60 DEG C is 1.1~1.3g/cm3。
Further, medicinal extract is mixed with pharmaceutically acceptable auxiliary material, dried, tabletting can obtain pill or tablet.Wherein, medicine
The acceptable auxiliary material of agent can be xylitol or glucose.It should be noted that pharmaceutically acceptable auxiliary material is not limited to
For xylitol or glucose.
The preparation method of this pharmaceutical preparation, it is simple and practicable, it is workable, it can largely avoid drug effect to be broken
It is bad, the content of active principle in pharmaceutical preparation is remained, so as to ensure drug effect.
The feature and performance of the present invention are described in further detail with reference to embodiments.
Embodiment 1
The present embodiment provides a kind of pharmaceutical preparation to relax bowel, it is by the pharmaceutical composition and xylitol system that relax bowel
Into the pharmaceutical composition includes：Fructus cannabis 10g, radix glycyrrhizae 3g, Semen Lablab Album 12g, cassia seed 10g, almond 7g, Siraitia grosvenorii 9g, peach kernel
5g, mulberries 12g, radish seed 10g, Semen sesami nigrum 10g, brush-cherry seed 9g and purple perilla 5g.
The preparation method of the pharmaceutical preparation, including：By the fructus cannabis in pharmaceutical composition, radix glycyrrhizae, Semen Lablab Album, cassia seed,
Siraitia grosvenorii, peach kernel, mulberries, radish seed, Semen sesami nigrum, brush-cherry seed and purple perilla mixing, according to solid-liquid ratio 1:6 mix with water, at 100 DEG C
Temperature conditionss under decoct 20min after, add almond and continue to filter to obtain the first filtrate and filter residue after decocting 12min, through by filter residue
Decoction 20min is mixed with 510g water and obtains the second filtrate, the first filtrate and the second filtrate are mixed to get liquid, liquid is carried out
The medicinal extract that the relative density at a temperature of 60 DEG C is 1.2g/cm3 is concentrated to give, by medicinal extract and xylitol according to weight ratio 6:1 mixing
Afterwards, dry, tabletting.
Embodiment 2
The present embodiment provides a kind of pharmaceutical preparation to relax bowel, it is by the pharmaceutical composition and glucose system that relax bowel
Into the pharmaceutical composition includes：Fructus cannabis 12g, radix glycyrrhizae 4g, Semen Lablab Album 9g, cassia seed 12g, almond 8g, Siraitia grosvenorii 10g, peach kernel
6g, mulberries 10g, radish seed 5g, Semen sesami nigrum 11g, brush-cherry seed 6g and purple perilla 6g.
The preparation method of the pharmaceutical preparation, including：By the fructus cannabis in pharmaceutical composition, radix glycyrrhizae, Semen Lablab Album, cassia seed,
Siraitia grosvenorii, peach kernel, mulberries, radish seed, Semen sesami nigrum, brush-cherry seed and purple perilla mixing, according to solid-liquid ratio 1:5 mix with water, at 90 DEG C
Temperature conditionss under decoct 25min after, add almond and continue to filter to obtain the first filtrate and filter residue after decocting 10min, through by filter residue
Decoction 15min is mixed with 600g water and obtains the second filtrate, the first filtrate and the second filtrate are mixed to get liquid, liquid is carried out
The medicinal extract that the relative density at a temperature of 60 DEG C is 1.1g/cm3 is concentrated to give, by medicinal extract and glucose according to weight ratio 5:1 mixing
Afterwards, dry, tabletting.
Embodiment 3
The present embodiment provides a kind of pharmaceutical preparation to relax bowel, it is by the pharmaceutical composition and glucose system that relax bowel
Into the pharmaceutical composition includes：Fructus cannabis 13g, radix glycyrrhizae 7g, Semen Lablab Album 15g, cassia seed 13g, almond 5g, Siraitia grosvenorii 13g, peach
Benevolence 7g, mulberries 9g, radish seed 6g, Semen sesami nigrum 9g, brush-cherry seed 10g and purple perilla 8g.
The preparation method of the pharmaceutical preparation, including：By the fructus cannabis in pharmaceutical composition, radix glycyrrhizae, Semen Lablab Album, cassia seed,
Siraitia grosvenorii, peach kernel, mulberries, radish seed, Semen sesami nigrum, brush-cherry seed and purple perilla mixing, according to solid-liquid ratio 1:8 mix with water, at 95 DEG C
Temperature conditionss under decoct 15min after, add almond and continue to filter to obtain the first filtrate and filter residue after decocting 15min, through by filter residue
Decoction 25min is mixed with 800g water and obtains the second filtrate, the first filtrate and the second filtrate are mixed to get liquid, liquid is carried out
The medicinal extract that the relative density at a temperature of 60 DEG C is 1.3g/cm3 is concentrated to give, by medicinal extract and glucose according to weight ratio 7:1 mixing
Afterwards, dry, tabletting.
Embodiment 4
The present embodiment provides a kind of pharmaceutical preparation to relax bowel, it is by the pharmaceutical composition and xylitol system that relax bowel
Into the pharmaceutical composition includes：Fructus cannabis 11g, radix glycyrrhizae 2g, Semen Lablab Album 10g, cassia seed 11g, almond 6g, Siraitia grosvenorii 12g, peach
Benevolence 8g, mulberries 11g, radish seed 9g, Semen sesami nigrum 14g, brush-cherry seed 8g and purple perilla 10g.
The preparation method of the pharmaceutical preparation, including：By the fructus cannabis in pharmaceutical composition, radix glycyrrhizae, Semen Lablab Album, cassia seed,
Siraitia grosvenorii, peach kernel, mulberries, radish seed, Semen sesami nigrum, brush-cherry seed and purple perilla mixing, according to solid-liquid ratio 1:8 mix with water, at 95 DEG C
Temperature conditionss under decoct 15min after, add almond and continue to filter to obtain the first filtrate and filter residue after decocting 15min, through by filter residue
Decoction 25min is mixed with 800g water and obtains the second filtrate, the first filtrate and the second filtrate are mixed to get liquid, liquid is carried out
The medicinal extract that the relative density at a temperature of 60 DEG C is 1.2g/cm3 is concentrated to give, by medicinal extract and xylitol according to weight ratio 6:1 mixing
Afterwards, dry, tabletting.
Embodiment 5
The present embodiment provides a kind of pharmaceutical preparation to relax bowel, it is made by the pharmaceutical composition to relax bowel, the medicine
Compositions include：Fructus cannabis 15g, radix glycyrrhizae 8g, Semen Lablab Album 11g, cassia seed 9g, almond 10g, Siraitia grosvenorii 14g, peach kernel 10g, mulberry
Shen 14g, radish seed 7g, Semen sesami nigrum 13g, brush-cherry seed 7g and purple perilla 3g.
The preparation method of the pharmaceutical preparation, including：By the fructus cannabis in pharmaceutical composition, radix glycyrrhizae, Semen Lablab Album, cassia seed,
Siraitia grosvenorii, peach kernel, mulberries, radish seed, Semen sesami nigrum, brush-cherry seed and purple perilla are mixed to get mixture, by mixture and water and prebiotic
After bacterium mixing after fermentation at a temperature of 100 DEG C, pharmaceutical solutions are obtained by filtration.Wherein, mixture and water and the weight of probiotics
Than for 3：1：1.
Embodiment 6
The present embodiment provides a kind of pharmaceutical preparation to relax bowel, it is made by the pharmaceutical composition to relax bowel, the medicine
Compositions include：Fructus cannabis 12g, radix glycyrrhizae 6g, Semen Lablab Album 14g, cassia seed 13g, almond 9g, Siraitia grosvenorii 15g, peach kernel 9g, mulberry
Shen 13g, radish seed 8g, Semen sesami nigrum 15g, brush-cherry seed 8g and purple perilla 9g.
The preparation method of the pharmaceutical preparation, including：By the fructus cannabis in pharmaceutical composition, radix glycyrrhizae, Semen Lablab Album, cassia seed,
Siraitia grosvenorii, peach kernel, mulberries, radish seed, Semen sesami nigrum, brush-cherry seed and purple perilla are mixed to get mixture, by mixture and water and prebiotic
After bacterium mixing after fermentation at a temperature of 100 DEG C, pharmaceutical solutions are obtained by filtration.Wherein, mixture and water and the weight of probiotics
Than for 14：5：5.
Embodiment 7
The present embodiment provides a kind of pharmaceutical preparation to relax bowel, it is made by the pharmaceutical composition to relax bowel, the medicine
Compositions include：Fructus cannabis 14g, radix glycyrrhizae 10g, Semen Lablab Album 12g, cassia seed 15g, almond 6g, Siraitia grosvenorii 11g, peach kernel 8g, mulberry
Shen 15g, radish seed 11g, Semen sesami nigrum 12g, brush-cherry seed 7g and purple perilla 4g.
The preparation method of the pharmaceutical preparation, including：By the fructus cannabis in pharmaceutical composition, radix glycyrrhizae, Semen Lablab Album, cassia seed,
Siraitia grosvenorii, peach kernel, mulberries, radish seed, Semen sesami nigrum, brush-cherry seed and purple perilla are mixed to get mixture, by mixture and water and prebiotic
After bacterium mixing after fermentation at a temperature of 100 DEG C, pharmaceutical solutions are obtained by filtration.Wherein, mixture and water and the weight of probiotics
Than for 10:3:3.
Embodiment 8
The present embodiment provides a kind of pharmaceutical preparation to relax bowel, it is decocted by the pharmaceutical composition to relax bowel and is made,
The pharmaceutical composition includes：Fructus cannabis 10g, radix glycyrrhizae 5g, Semen Lablab Album 13g, cassia seed 14g, almond 7g, Siraitia grosvenorii 13g, peach kernel
6g, mulberries 12g, radish seed 12g, Semen sesami nigrum 14g, brush-cherry seed 9g and purple perilla 7g.
The preparation method of the pharmaceutical preparation, including：By the fructus cannabis in pharmaceutical composition, radix glycyrrhizae, Semen Lablab Album, cassia seed,
Siraitia grosvenorii, peach kernel, mulberries, radish seed, Semen sesami nigrum, brush-cherry seed and purple perilla are mixed to get mixture, by mixture and water and prebiotic
After bacterium mixing after fermentation at a temperature of 100 DEG C, pharmaceutical solutions are obtained by filtration.Wherein, mixture and water and the weight of probiotics
Than for 20:6:7.
Test example
1. case selection：
This group of case is constipation patient of the course of disease more than 1 year, has that awareness of defecation is few, bowel frequency is also few, and defecation is difficult, laborious,
Defecation is not smooth, dry and hard excrement, it is hard just, defecation is not felt only, and constipation is with least two illnesss in abdominal pain or abdominal discomfort symptom.
Age is 20~60,40 years old average.9 groups are randomly divided into, every group each 30, wherein experimental group is the 1st~9 group.9th group is control
Group.There was no significant difference for the data such as age of this 9 groups of patients, the state of an illness, is comparable.
2. therapeutic scheme：
The patient of 1-4 groups (experimental group) takes orally the pharmaceutical preparation of the offer of embodiment 1~4, daily medication three times, each taking
The dose of medicine is 10mg.The patient of 5-8 groups (experimental group) takes orally the pharmaceutical preparation of the offer of embodiment 5~8, takes medicine three daily
Secondary, the dose taken medicine every time is 100mL.9th group of (control group) patient takes orally blank placebo.Continuous treatment 4 months, treatment phase
Between without using other drugs.Its treatment results refer to table 1.
3. clinical evaluation standard：
Recovery from illness：Under conditions of medicine is not depended on, without the clinical manifestation of constipation；
Significantly：Under conditions of drug administration preparation, the constipation situation of patient substantially mitigates；
Improve：Under conditions of drug administration preparation, the constipation situation of patient has a degree of mitigation；
It is invalid：Patient does not have the change for finding the state of an illness under conditions of drug administration preparation.
1 clinical test results of table
| Project | Recovery from illness | Significantly | Improve | It is invalid |
| Embodiment 1 | 19 | 8 | 3 | 0 |
| Embodiment 2 | 19 | 10 | 1 | 0 |
| Embodiment 3 | 22 | 7 | 1 | 1 |
| Embodiment 4 | 17 | 10 | 1 | 2 |
| Embodiment 5 | 16 | 12 | 2 | 0 |
| Embodiment 6 | 21 | 9 | 0 | 1 |
| Embodiment 7 | 22 | 6 | 2 | 0 |
| Embodiment 8 | 21 | 8 | 1 | 0 |
| Control group | 0 | 0 | 2 | 28 |
As can be known from the results of Table 1, pharmaceutical composition provided by the invention has therapeutic effect well to constipation.Main table
Now：After medication, in the case where not using any other medicine, it can eliminate, relief of constipation symptom.And embodiment 1
~8 pharmaceutical preparations provided, to the data high efficiency of patient, sum were accounted for wherein fully recovering in 2 months with significant patient
More than 90%.Illustrate the pharmaceutical composition of the present invention and the treatment of constipation is imitated using pharmaceutical preparation made of the pharmaceutical composition
Fruit is good, has rapid-action, eutherapeutic advantage.
Embodiments described above is part of the embodiment of the present invention, instead of all the embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
- A kind of 1. pharmaceutical composition to relax bowel, it is characterised in that described pharmaceutical composition count in parts by weight including：10-15 parts of fructus cannabis, 2-10 parts of radix glycyrrhizae, 9-15 parts of Semen Lablab Album, 9-15 parts of cassia seed, 5-10 parts of almond, Siraitia grosvenorii 9-15 Part, 5-10 parts of peach kernel, 9-15 parts of mulberries, 5-12 parts of radish seed, 9-15 parts of Semen sesami nigrum, 6-10 parts of brush-cherry seed and purple perilla 3-10 Part.
- 2. the pharmaceutical composition according to claim 1 to relax bowel, it is characterised in that count in parts by weight, the fire Edestan is 11-14 parts, the radix glycyrrhizae is 3-8 parts, the Semen Lablab Album is 10-14 parts, the cassia seed is 10-14 parts, the apricot Benevolence is 6-9 parts, the Siraitia grosvenorii is 10-14 parts, the peach kernel is 6-9 parts, the mulberries are 10-14 parts, the radish seed is 6-10 parts, the Semen sesami nigrum be 10-14 parts, the brush-cherry seed is 7-9 parts, the purple perilla is 4-8 parts.
- 3. the pharmaceutical composition according to claim 1 or 2 to relax bowel, it is characterised in that count in parts by weight, it is described Fructus cannabis is 12-13 parts, the radix glycyrrhizae is 4-6 parts, the Semen Lablab Album is 11-13 parts, the cassia seed is 11-13 parts, described Almond is 7-8 parts, the Siraitia grosvenorii is 11-13 parts, the peach kernel is 7-8 parts, the mulberries are 11-13 parts, the radish seed For 7-9 parts, the Semen sesami nigrum be 11-13 parts, the brush-cherry seed is 8-9 parts, the purple perilla is 5-6 parts.
- 4. a kind of pharmaceutical preparation to relax bowel, it is characterised in that it is relaxed bowel by claim 1-3 any one of them Pharmaceutical composition and pharmaceutically acceptable auxiliary material composition.
- 5. the pharmaceutical preparation according to claim 4 to relax bowel, it is characterised in that the formulation of the pharmaceutical preparation includes Pill or tablet.
- 6. a kind of pharmaceutical preparation to relax bowel, it is characterised in that it is relaxed bowel by claim 1-3 any one of them Pharmaceutical composition fermentation is made.
- A kind of 7. pharmaceutical preparation to relax bowel as claimed in claim 6, it is characterised in that including：Count in parts by weight, will The fructus cannabis, the radix glycyrrhizae, the Semen Lablab Album, the cassia seed, the almond, the Siraitia grosvenorii, the peach kernel, the mulberry Shen, the radish seed, the Semen sesami nigrum, the brush-cherry seed and the purple perilla are mixed to get mixture, by the mixture and water And pharmaceutical solutions are obtained by filtration after fermentation at a temperature of 80-100 DEG C after probiotics mixing.
- 8. a kind of preparation method of the pharmaceutical preparation to relax bowel, it is characterised in that it includes：By fructus cannabis 10-15 parts by weight, radix glycyrrhizae 2-10 parts by weight, Semen Lablab Album 9-15 parts by weight, cassia seed 9-15 parts by weight, arhat Fruit 9-15 parts by weight, peach kernel 5-10 parts by weight, mulberries 9-15 parts by weight, radish seed 5-12 parts by weight, Semen sesami nigrum 9-15 parts by weight, Brush-cherry seed 6-10 parts by weight and the mixing of purple perilla 3-10 parts by weight, according to solid-liquid ratio 1:5~8 are blended in 90-100 DEG C of temperature with water After decocting 15-25min under the conditions of degree, add almond 5-10 parts by weight continue to filter after 10~15min of decoction the first filtrate and Filter residue, mixes 15~25min of decoction with water by the filter residue and obtains the second filtrate, by first filtrate and second filtrate Liquid is mixed to get, liquid is concentrated to give medicinal extract.
- 9. the preparation method of the pharmaceutical preparation according to claim 8 to relax bowel, it is characterised in that in parts by weight Meter, the fructus cannabis is 11-14 parts, the radix glycyrrhizae is 3-8 parts, the Semen Lablab Album is 10-14 parts, the cassia seed is 10-14 Part, the almond are 6-9 parts, the Siraitia grosvenorii is 10-14 parts, the peach kernel is 6-9 parts, the mulberries are 10-14 parts, described Radish seed is 6-10 parts, the Semen sesami nigrum is 10-14 parts, the brush-cherry seed is 7-9 parts, the purple perilla is 4-8 parts.
- 10. the preparation method of the pharmaceutical preparation according to claim 8 to relax bowel, it is characterised in that further include institute State medicinal extract mix, dry with pharmaceutically acceptable auxiliary material, tabletting.
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| CN108704096A (en) * | 2018-06-04 | 2018-10-26 | 厦门元之道生物科技有限公司 | A kind of herb fermenting agent and preparation method thereof with reinforcing spleen to promote digestion function |
| CN112772812A (en) * | 2019-11-04 | 2021-05-11 | 晨光生物科技集团邯郸有限公司 | Composition for tonifying qi, moistening intestines and relaxing bowels and preparation method thereof |
| CN113785948A (en) * | 2021-09-14 | 2021-12-14 | 三原利华生物技术有限公司 | Solid beverage capable of benefiting qi, promoting production of body fluid and relaxing bowel and preparation method thereof |
| CN114176145A (en) * | 2021-12-23 | 2022-03-15 | 廖章鼎 | Weight-losing tea bag and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108704096A (en) * | 2018-06-04 | 2018-10-26 | 厦门元之道生物科技有限公司 | A kind of herb fermenting agent and preparation method thereof with reinforcing spleen to promote digestion function |
| CN108704096B (en) * | 2018-06-04 | 2021-01-12 | 厦门元之道生物科技有限公司 | Preparation method of traditional Chinese medicine leavening agent with spleen invigorating and digestion promoting functions |
| CN112772812A (en) * | 2019-11-04 | 2021-05-11 | 晨光生物科技集团邯郸有限公司 | Composition for tonifying qi, moistening intestines and relaxing bowels and preparation method thereof |
| CN113785948A (en) * | 2021-09-14 | 2021-12-14 | 三原利华生物技术有限公司 | Solid beverage capable of benefiting qi, promoting production of body fluid and relaxing bowel and preparation method thereof |
| CN114176145A (en) * | 2021-12-23 | 2022-03-15 | 廖章鼎 | Weight-losing tea bag and preparation method thereof |
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Application publication date: 20180501 |