CN104353028A - Pharmaceutical combination for treating asthma and preparation method thereof - Google Patents

Pharmaceutical combination for treating asthma and preparation method thereof Download PDF

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Publication number
CN104353028A
CN104353028A CN201410563123.6A CN201410563123A CN104353028A CN 104353028 A CN104353028 A CN 104353028A CN 201410563123 A CN201410563123 A CN 201410563123A CN 104353028 A CN104353028 A CN 104353028A
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parts
radix
thallus
thallus laminariae
pharmaceutical composition
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赵岚
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Zhejiang Industry and Trade Vocational College
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Zhejiang Industry and Trade Vocational College
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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Abstract

The invention provides a medicinal composition for treating asthma and a preparation method thereof. The medicinal composition for treating the asthma is prepared by adopting the process that 1-3 parts of ginseng, 2-6 parts of radix achyranthis bidentatae, 5-10 parts of prepared rehmannia root, 5-10 parts of radix ophiopogonis, 3-6 parts of dogwood, 1-3 parts of fructus lycii, 1-3 parts of schisandra chinensis, 3-6 parts of rhizoma zingiberis, 5-10 parts of rhizoma anemarrhenae, 5-10 parts of fritillaria thun-bergli, 5-10 parts of arisaema cum bile, 3-6 parts of rhizoma pinelliae, 2-5 parts of pericarpium citri reticulatae, 1-3 parts of saccharina japonica, 10-13 parts of platycodon grandiflorum, 11-13 parts of impatiens balsamina, 1-3 parts of walnut, 1-3 parts of sea-tangle and 1-3 parts of undaria pinnatifida are subjected to extracting, concentrating, drying, crushing and pelletizing. The medicinal composition has the efficacy of quickly solving the asthma symptom and has the characteristics of scientific prescription, simple preparation method, low processing cost, obvious treatment effect and no toxic or side effects.

Description

A kind of pharmaceutical composition for the treatment of asthma and preparation method thereof
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of asthma and preparation method thereof.
Background technology
Asthma is by the various kinds of cell particularly chronic airway inflammation that participates in of mastocyte, eosinophilic granulocyte and T lymphocyte, in susceptible person, this kind of inflammation can cause panting of recurrent exerbation, the symptoms such as tachypnea, uncomfortable in chest and (or) cough, how occurring at night and (or) morning, air flue increases multiple stimulating factor reactivity.But symptom can be alleviated voluntarily or through treatment.In the recent decade, the U.S., Britain, Australia, the national asthma prevalence such as New Zealand and mortality rate on the rise, about there are 100,000,000 asthmatic patients in the whole world, become a kind of major chronic illnesses of serious threat public health, the prevalence of China's asthma is about 1%, child Ke Da 3%, about has more than 1,000 ten thousand asthmatic patients according to the measuring and calculating whole nation.Typical asthma, has premonitory symptom as sneeze, watery nasal discharge before outbreak, cough, uncomfortable in chest etc., as processed not in time, asthma can be there is because bronchial obstruction increases the weight of, severe patient can be forced to take seat or in orthopnea,, even there is cyanosis etc. in dry cough or cough up a large amount of white foam expectorant, but generally can voluntarily or with alleviating voluntarily or with after the treatments such as suppressing panting calming medicine, some patient can again show effect after alleviation a few hours, even causes status asthmaticus.
Chinese medicine thinks that asthma attack seasonal pathogen is contained in lung, but the root of disease is then relevant with kidney and spleen, this is because lung governing qi and take charge of breathing, but the basis of gas is at kidney, suffering from a deficiency of the kidney then can not improving inspiration by invigorating kidney-QI, causes purgation gas to join not normal, << Lei Zheng Zhi Cai >> alleged " the lung being the dominator of QI; the kidney being the root of QI, lung master give vent to anger, kidney governing inspiration; negative and positive intersect; breathing be and, if cashier's abnormal ascending-descending of QI, here this breathes heavily work." describe " and lung governing qi, kidney improving inspiration by invigorating kidney-QI, gas for lung root in kidney " lung kidney between substantial connection, also can common deficiency of kidney-QI person to the dialectical of asthmatic patient.Lung is " device of storage expectorant ", and spleen is " the source of producing phlegm ", if dysfunction of the spleen in transportation, then poly-liquid becomes expectorant, on hinder and cause asthma in lung, << card controls gains in depth of comprehension >> cloud: " the lung being the dominator of QI, spleen then lung mother also; spleen lung has the deficiency that thanks to then gasifies, and deficiency is then very brief and breathe heavily." especially there is prior effect with the prosperity and decline of kidney qi in the advance and retreat of asthma in spleen kidney.
In recent years, along with the further investigation of the etiology and pathogenesis to bronchial asthma, recognize that asthma is a kind of chronic airway inflammation, and there is the Clinical symptoms of airway hyperreactivity, so had again new concept in the preventing and treating of asthma, think and be used alone bronchodilatation medicine to carry out treatment be comprehensive not, for in, severe asthma, only by using bronchodilators regularly, as β2agonists, even harmful, because β2agonists is without antiinflammatory action, simple symptomatic treatment can cover inflammatory development, airway hyperreactivity is increased the weight of, thus necessary use in conjunction anti-inflammatory drug, patient is treated, but medication is loaded down with trivial details, treatment cycle is long, and use antibiotic for a long time, hormone medicine has very large side effect.
The prescription of Chinese traditional treatment asthma is various, the specific aim of each prescription is different, and the decoction of Chinese medicine decoction and take all very inconvenient, decocting time and take improper meeting to treatment bring very large impact, therefore need one effectively can either treat symptoms of asthma, the medicine can conveniently taken again solves patient suffering.
Summary of the invention
In order to overcome above-mentioned prior art defect, the object of the present invention is to provide a kind of pharmaceutical composition for the treatment of asthma and preparation method thereof, from motherland's medical treasure-house, according to traditional Chinese medical science prescription theory, skim the cream off milk, reconfigure, its drug-specific is worked for symptoms of asthma, play effect for the treatment of asthma, adopt modern biotechnology pharmacy means, there is prescription science, preparation method is simple, processing cost is low, evident in efficacy, without any side effects feature.
In order to solve the problems of the technologies described above, the present invention takes following technical scheme:
Treat a pharmaceutical composition for asthma, comprising: Radix Ginseng, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Radix Ophiopogonis, Fructus Corni, Fructus Lycii, Fructus Schisandrae Chinensis, Rhizoma Zingiberis, the Rhizoma Anemarrhenae, Bulbus Fritillariae Uninbracteatae, Arisaema Cum Bile, Pinellia leaven, Pericarpium Citri Reticulatae, Thallus Laminariae (Thallus Eckloniae), Radix Platycodonis, Flos Impatientis, Semen Juglandis.
Further, a kind of pharmaceutical composition for the treatment of asthma, its raw material constituent also comprises: Thallus Laminariae (Thallus Eckloniae), Thallus Laminariae.
Further, treat insufficiency of the spleen pharmaceutical composition, its raw material weight constituent is: Radix Ginseng 1 part ~ 3 parts, Radix Achyranthis Bidentatae 2 parts ~ 6 parts, Radix Rehmanniae Preparata 5 parts ~ 10 parts, Radix Ophiopogonis 5 parts ~ 10 parts, Fructus Corni 3 parts ~ 6 parts, Fructus Lycii 1 part ~ 3 parts, Fructus Schisandrae Chinensis 1 part ~ 3 parts, Rhizoma Zingiberis 3 parts ~ 6 parts, the Rhizoma Anemarrhenae 5 parts ~ 10 parts, Bulbus Fritillariae Uninbracteatae 5 parts ~ 10 parts, Arisaema Cum Bile 5 parts ~ 10 parts, Pinellia leaven 3 parts ~ 6 parts, Pericarpium Citri Reticulatae 2 parts ~ 5 parts, 1 part ~ 3 parts, Thallus Laminariae (Thallus Eckloniae), Radix Platycodonis 10 parts ~ 13 parts, Flos Impatientis 11 parts ~ 13 parts, Semen Juglandis 1 part ~ 3 parts, Thallus Laminariae (Thallus Eckloniae) 1 part ~ 3 parts, Thallus Laminariae 1 part ~ 3 parts.
Wherein, the Main Function of said herbal medicine composition is:
Radix Ginseng: sweet in the mouth, micro-hardship, property is put down; Return spleen, lung, heart channel; Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.Radix Codonopsis is put down, and sweet in the mouth, has the ability of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, has the effect of Gastrointestinal motility adjustment, antiulcer, gastric acid secretion inhibiting, reduction pepsin activity.
Radix Achyranthis Bidentatae: walk and can mend, property is apt to descending, therefore enters Liver and kidney, cures mainly cold-damp flaccidity syndrome and arthralgia syndrome, liver spleen is suffered from a deficiency of the kidney, and this property of medicine is walked and descending, and it can also must by eliminating impediment by cold-damp.Top capping liver then muscle is relaxed, descending, manages knee joint, and promoting the circulation of blood then pain stops; By vim and vigour, still cloud can lead to qi stagnation hemagglutination also.The detailed property of medicine, gas is used as numbness.Fire of getting mildewed in warm conditions is rotten, the shrivelled disease of blood also, blood and living, pain oneself stop; Blood stored in the liver, kidney storing essence, high invigorating the liver and kidney, then hemapodium and essence is full, all cards are from recover.
Radix Rehmanniae Preparata: sweet in the mouth, warm in nature, returns liver, kidney channel; Main moist, beneficial essence of enriching blood fills out marrow, for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, collapse that more than, hepatic and renal YIN deficiency, hectic fever night sweat, seminal emission sexual impotence, infertility, menoxenia, metrostaxis, soreness of the waist and knees, Hiccough and deaf, the head are dim-sighted, early whitening of beard and hair, quench one's thirst, constipation, dyspnea with rapid and short breath of suffering from a deficiency of the kidney.
Radix Ophiopogonis: sweet in the mouth, micro-hardship, cold nature, GUIXIN, lung, stomach warp; Return YIN nourishing and the production of body fluid promoting, lung moistening clear away heart-fire, for dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, Tianjin wound are thirsty, interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.
Fructus Corni: sour-puckery flavor, slightly warm in nature, clinical practice has the function such as invigorating the liver and kidney, arresting seminal emission gas, solid collapse, stomach invigorating tonifying YANG, and the traditional Chinese medical science is commonly used to treat soreness of waist and knee joint, dizzy, tinnitus, seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shake the diseases such as scattered pulse, neurasthenia, menoxenia.
Fructus Lycii: profit and nourishing, doublely can bring down a fever, and specially in the kidney invigorating, lung moistening, promote the production of body fluid, QI invigorating, be the key medicine of Liver and kidney kidney-YIN being deficient, tired interior-heat tonification; Old man deficiency of YIN person ten seven or eight, therefore to take house be the top grade of replenishing vital essence to improve eyesight; The many meanings of former times people its can spermatogenesis QI invigorating, except yin asthenia generating intrinsic heat improving eyesight person, lid heat is moved back then cloudy raw, and cloudy raw then essence and blood is from long, and liver opening at eye, Heisui River God Light belongs to kidney, and two dirty cloudy gas gains, then order is self-evident.
Fructus Schisandrae Chinensis: the five tastes are salty standby, and acid solely victory, can restrain lung qi, cure mainly asthenia chronic cough; Lid lung libido is received, if chronic cough, the burnt leaf of lung is lifted, body fluid being unable to be produced, asthenia then lung because of gas weary, excessive thirst is more than, holds back it with this, moistens it, then its dirty property, and make cough peaceful, spirit is from prosperous.
Rhizoma Zingiberis: nature and flavor are pungent, hot, returns spleen, stomach, kidney, the heart, lung meridian, has warming spleen and stomach for dispelling cold, and the function of warming the meridian for stopping bleeding, controls Deficiency and coldness of spleen and stomach, and stomachache is vomited and diarrhoea, and tell nosebleed metrorrhagia, yang deficiency is lost blood.
Rhizoma Anemarrhenae bitter in the mouth, sweet, cold in nature, return lung, stomach, kidney channel, clearing away heat-fire, promote the production of body fluid and moisturize; For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.Cure mainly epidemic febrile disease, high hot excessive thirst, cough and asthma, cough caused by dryness, constipation, osteopyrexia and fever, restlessness of asrhenia type and insomnia, stranguria with turbid discharge of quenching one's thirst.
Bulbus Fritillariae Uninbracteatae is cold in nature, bitter in the mouth, returns lung, heart channel, can be used for treatment expectorant heat syndrome cough and breathes heavily, yellow thick card of coughing up phlegm; To hold concurrently again sugariness, therefore kind nourishing the lung to arrest cough, treatment lung has the card that scorching cough expectorant is few and sticky, and the deficiency syndrome such as deficiency of YIN cough caused by dryness chronic cough; Also have the merit of eliminating stagnation dissipating depression of QI, the uncomfortable in chest vexed card for the treatment of caused by combination of phlegm and heat, and the disease such as scrofula sucutaneous nodule.
Arisaema Cum Bile taste is micro-pungent and bitter, cool in nature, enters the heart, liver, lung three warp, main clearing away fire and eliminating phlegm, relieving convulsion fixed chronic, control middle wind-phlegm fan, infantile convulsion epilepsy, phlegm-fire breathe heavily cough, phlegm-accumulating vertigo.
Pinellia leaven bitter in the mouth, pungent, property is put down; Enter lung, spleen, large intestine three warp, can preventing phlegm from forming and stopping coughing, help digestion alleviating distention in middle-JIAO, control to have loose bowels, cough.
Pericarpium Citri Reticulatae sweet-bitter flavor, enters spleen channel, stomach through, lung meridian, can regulating qi-flowing for strengthening spleen, and in tune, dampness, reduces phlegm.
Thallus Laminariae (Thallus Eckloniae) bitter in the mouth, cold in nature, nontoxic, enter stomach through, spleen channel, have eliminating phlegm and softening indurated mass, effect that the diuretic that expels the heat-evil, relieving cough and asthma, lipoid and reducing blood pressure of dispelling, eliminating stagnation are anticancer, for falling under goiter, scrofula, hernia, cough with asthma, edema, hypertension, coronary heart disease, obesity.
Radix Platycodonis bitter in the mouth, pungent, slightly warm in nature, enter lung meridian, have lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, the merit that fills blood, mend five kinds of over strain, foster the spirit of nobility, cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.
Flos Impatientis sweet in the mouth, property are flat, nontoxic, return Liver Channel; Have wind-damp dispelling, invigorate blood circulation, relaxing muscles and tendons, pain relieving merit, dispelling the wind and dampness pathogens pain, sprain and contusion hinder, innominate toxic swelling, eczema scrotum.
Semen Juglandis is warm in nature, sweet in the mouth, nontoxic, enter kidney, lung, large intestine channel, have stomach invigorating, enrich blood, lung moistening, repose, intestine moistening, cough-relieving effect.
Wherein, the Main Function of the medicinal herb components of above-mentioned interpolation is:
Thallus Laminariae (Thallus Eckloniae) bitter in the mouth, cold in nature, nontoxic, return liver, stomach, kidney, spleen channel, harness the river swollen, drench disease, wet beriberi, control again goiter, chronic tracheitis, cough.
Thallus Laminariae is cool in nature, sweet-salty, returns lung, kidney, large intestine channel; Have heat clearing away, promote the production of body fluid, effect of relieving constipation.
Another object of the present invention is the preparation method providing described Chinese medicine composition, comprises the following steps:
Step S01, the pure water adding 10 times ~ 20 times after Radix Ginseng, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Radix Ophiopogonis, Fructus Corni, Fructus Lycii, Fructus Schisandrae Chinensis, Rhizoma Zingiberis, the Rhizoma Anemarrhenae, Bulbus Fritillariae Uninbracteatae, Arisaema Cum Bile, Pinellia leaven, Pericarpium Citri Reticulatae, Thallus Laminariae (Thallus Eckloniae), Radix Platycodonis, Flos Impatientis, Semen Juglandis, Thallus Laminariae (Thallus Eckloniae), Thallus Laminariae co-grinding is adopted dynamic successive stages countercurrent extraction 6 hours ~ 10 hours under the condition of 95 DEG C ~ 100 DEG C, filter, extracting solution is for subsequent use;
Step S02, the extracting solution obtained by step S01, through super-dry, pulverizing, adds adjuvant, granulates, makes required dosage form.
Further, in step S01, the condition pulverized after described Radix Ginseng, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Radix Ophiopogonis, Fructus Corni, Fructus Lycii, Fructus Schisandrae Chinensis, Rhizoma Zingiberis, the Rhizoma Anemarrhenae, Bulbus Fritillariae Uninbracteatae, Arisaema Cum Bile, Pinellia leaven, Pericarpium Citri Reticulatae, Thallus Laminariae (Thallus Eckloniae), Radix Platycodonis, Flos Impatientis, Semen Juglandis, Thallus Laminariae (Thallus Eckloniae), Thallus Laminariae mixing is: the medicinal mixture after pulverizing crosses 10 mesh sieves, pulverized and be slightly unfavorable for extracting, it is meticulous to pulverize, and extracting solution thickness is unfavorable for filtering.
Further, in step S02, extracting solution through super-dry, pulverize after particle diameter between 10 μm ~ 25 μm.
Further, in step S02, the mode of described extracting solution drying is: spraying dry, or vacuum drying, or vacuum lyophilization, or constant-pressure and high-temperature is dry.
Further, in step S02, the dosage form of described pharmaceutical composition is granule or pill or soft capsule or capsule or tablet.
Advantage of the present invention is:
The pharmaceutical composition for the treatment of asthma disclosed by the invention, for pure Chinese medicinal preparation, in conjunction with modern pharmaceutical technique, the basis of ancient prescription is revised, make curative effect rapider, prescription is simplified, preparation method is simple, processing cost is low, evident in efficacy, without any side effects, the efficacy of a drug is strong, instant effect, can eliminate rapidly cough symptom, adopt modern crafts pharmacy, conveniently take; Adopt dynamic successive stages countercurrent extraction, improve utilization rate and the drug effect of effective ingredient.
Detailed description of the invention
Below provide specific embodiments of the invention, be used for being described in further detail the present invention.
Experimental technique in following embodiment, if no special instructions, is conventional method.Medicinal raw material used in following embodiment, reagent material etc., if no special instructions, be commercially available purchase product.
Embodiment 1
A kind of preparation for the treatment of the granule of the pharmaceutical composition of asthma
Crude drug forms: (unit: g)
Radix Ginseng 100, Radix Achyranthis Bidentatae 200, Radix Rehmanniae Preparata 500, Radix Ophiopogonis 500, Fructus Corni 300, Fructus Lycii 100, Fructus Schisandrae Chinensis 100, Rhizoma Zingiberis 300, the Rhizoma Anemarrhenae 500, Bulbus Fritillariae Uninbracteatae 500, Arisaema Cum Bile 500, Pinellia leaven 300, Pericarpium Citri Reticulatae 200, Thallus Laminariae (Thallus Eckloniae) 100, Radix Platycodonis 1000, Flos Impatientis 1100, Semen Juglandis 100, Thallus Laminariae (Thallus Eckloniae) 100, Thallus Laminariae 100.
Prepare by the following method:
(1) Radix Ginseng, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Radix Ophiopogonis, Fructus Corni, Fructus Lycii, Fructus Schisandrae Chinensis, Rhizoma Zingiberis, the Rhizoma Anemarrhenae, Bulbus Fritillariae Uninbracteatae, Arisaema Cum Bile, Pinellia leaven, Pericarpium Citri Reticulatae, Thallus Laminariae (Thallus Eckloniae), Radix Platycodonis, Flos Impatientis, Semen Juglandis, Thallus Laminariae (Thallus Eckloniae), the Thallus Laminariae co-grinding 66kg that adds water after crossing 10 mesh sieves adopts dynamic successive stages countercurrent extraction 10 hours at 95 DEG C, filter, extracting solution is for subsequent use;
(2) by the extracting solution that (1) obtains, be under the condition of 95 DEG C in normal pressure temperature, be condensed into dry cream, through micronizing, obtain the powder 990g of particle diameter between 10 μm ~ 25 μm; According to drug powder: starch: the ratio of sucrose=3:1:1 adds starch 330g, sucrose 330g, mix homogeneously, granulate, make granule, subpackage, every bag of 5g, be total to obtain granule 330 bags.
Embodiment 2
A kind of preparation for the treatment of the medicament composition capsule agent of asthma
Crude drug forms: (unit: g)
Radix Ginseng 300, Radix Achyranthis Bidentatae 600, Radix Rehmanniae Preparata 1000, Radix Ophiopogonis 1000, Fructus Corni 600, Fructus Lycii 300, Fructus Schisandrae Chinensis 300, Rhizoma Zingiberis 600, the Rhizoma Anemarrhenae 1000, Bulbus Fritillariae Uninbracteatae 1000, Arisaema Cum Bile 1000, Pinellia leaven 600, Pericarpium Citri Reticulatae 500, Thallus Laminariae (Thallus Eckloniae) 300, Radix Platycodonis 1300, Flos Impatientis 1300, Semen Juglandis 300, Thallus Laminariae (Thallus Eckloniae) 300, Thallus Laminariae 300.
Prepare by the following method:
(1) Radix Ginseng, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Radix Ophiopogonis, Fructus Corni, Fructus Lycii, Fructus Schisandrae Chinensis, Rhizoma Zingiberis, the Rhizoma Anemarrhenae, Bulbus Fritillariae Uninbracteatae, Arisaema Cum Bile, Pinellia leaven, Pericarpium Citri Reticulatae, Thallus Laminariae (Thallus Eckloniae), Radix Platycodonis, Flos Impatientis, Semen Juglandis, Thallus Laminariae (Thallus Eckloniae), the Thallus Laminariae co-grinding 147.5kg that adds water after crossing 10 mesh sieves adopts dynamic successive stages countercurrent extraction 6 hours at 100 DEG C, filter, extracting solution is for subsequent use;
(2) by the extracting solution that (1) obtains, at drying chamber pressure 110 Pa, temperature of heating plate 43 DEG C, pre-freezing temperature-42 DEG C, freeze-off time 8 hours; Sublimation drying mode is for be directly set as 49 DEG C by shelf temperature, and in the middle part of cold-trap, circulation pipe temperature is set as-44 DEG C, and drying time is to filtrate lyophilization process under the condition of 7 hours; After through micronizing; obtain particle diameter at the pharmaceutical composition powder 1.89kg of 10 μm ~ 25 μm; add 70% appropriate amount of ethanol; 1 hour is dried with the temperature of 60 DEG C after mixing thoroughly; granulate, dry 1.5 hours with the temperature of 70 DEG C, after drying by medicinal powder mixture powder through the encapsulated process of granulator; every encapsulated 400mg, obtains capsule 4725.
Embodiment 3
A kind of preparation for the treatment of the medicinal composition tablets of asthma
Crude drug forms: (unit: kg)
Radix Ginseng 0.2, Radix Achyranthis Bidentatae 0.5, Radix Rehmanniae Preparata 0.7, Radix Ophiopogonis 0.7, Fructus Corni 0.4, Fructus Lycii 0.2, Fructus Schisandrae Chinensis 0.2, Rhizoma Zingiberis 0.5, the Rhizoma Anemarrhenae 0.7, Bulbus Fritillariae Uninbracteatae 0.7, Arisaema Cum Bile 0.7, Pinellia leaven 0.4, Pericarpium Citri Reticulatae 0.3, Thallus Laminariae (Thallus Eckloniae) 0.2, Radix Platycodonis 1.2, Flos Impatientis 1.2, Semen Juglandis 0.2, Thallus Laminariae (Thallus Eckloniae) 0.2, Thallus Laminariae 0.2.
Prepare by the following method:
(1) Radix Ginseng, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Radix Ophiopogonis, Fructus Corni, Fructus Lycii, Fructus Schisandrae Chinensis, Rhizoma Zingiberis, the Rhizoma Anemarrhenae, Bulbus Fritillariae Uninbracteatae, Arisaema Cum Bile, Pinellia leaven, Pericarpium Citri Reticulatae, Thallus Laminariae (Thallus Eckloniae), Radix Platycodonis, Flos Impatientis, Semen Juglandis, Thallus Laminariae (Thallus Eckloniae), the Thallus Laminariae co-grinding 188kg that adds water after crossing 10 mesh sieves adopts dynamic successive stages countercurrent extraction 7 hours at 96 DEG C, filter, extracting solution is for subsequent use;
(2) by the extracting solution that (1) obtains, be 47kPa at dry pressure, temperature is the drug extract solid under 71 DEG C of conditions, filtrate being dried to 1.41kg; After through micronizing, obtain particle diameter at the pharmaceutical composition powder 1.41kg of 10 μm ~ 25 μm, add 75% appropriate amount of ethanol, granulate, dry 1.5 hours with the temperature of 80 DEG C, after drying by medicinal mixture powder through tabletting machine process, every sheet 400mg, obtains medicine 3525.
Embodiment 4
A kind of preparation for the treatment of the medicinal composition soft capsule agent of asthma
Crude drug forms: (unit: kg)
Radix Ginseng 1, Radix Achyranthis Bidentatae 2, Radix Rehmanniae Preparata 6, Radix Ophiopogonis 7, Fructus Corni 6, Fructus Lycii 2, Fructus Schisandrae Chinensis 1, Rhizoma Zingiberis 4, the Rhizoma Anemarrhenae 8, Bulbus Fritillariae Uninbracteatae 9, Arisaema Cum Bile 10, Pinellia leaven 6, Pericarpium Citri Reticulatae 5, Thallus Laminariae (Thallus Eckloniae) 3, Radix Platycodonis 12, Flos Impatientis 13, Semen Juglandis 1, Thallus Laminariae (Thallus Eckloniae) 1, Thallus Laminariae 1.
Prepare by the following method:
(1) Radix Ginseng, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Radix Ophiopogonis, Fructus Corni, Fructus Lycii, Fructus Schisandrae Chinensis, Rhizoma Zingiberis, the Rhizoma Anemarrhenae, Bulbus Fritillariae Uninbracteatae, Arisaema Cum Bile, Pinellia leaven, Pericarpium Citri Reticulatae, Thallus Laminariae (Thallus Eckloniae), Radix Platycodonis, Flos Impatientis, Semen Juglandis, Thallus Laminariae (Thallus Eckloniae), the Thallus Laminariae co-grinding 1000kg that adds water after crossing 10 mesh sieves adopts dynamic successive stages countercurrent extraction 8 hours at 97 DEG C, filter, extracting solution is for subsequent use;
(2) by the extracting solution that (1) obtains, when inlet temperature 205 DEG C, pan feeding flow 65mL/min, shower nozzle rotating speed 25000r/min, spraying dry obtains drug powder 14.7kg; Add Cera Flava, hydrogenated palm oil, soybean phospholipid fully stir, mix homogeneously, leave standstill, evacuation, treats that in medicinal liquid, bubble is removed substantially, and with the glue pelleting changed, every dress 400mg suppresses, and obtains soft capsule 50000.
Embodiment 5
A kind of preparation for the treatment of the pharmaceutical composition pill of asthma
Crude drug forms: (unit: kg)
Radix Ginseng 1, Radix Achyranthis Bidentatae 2, Radix Rehmanniae Preparata 7, Radix Ophiopogonis 9, Fructus Corni 5, Fructus Lycii 1, Fructus Schisandrae Chinensis 2, Rhizoma Zingiberis 3, the Rhizoma Anemarrhenae 6, Bulbus Fritillariae Uninbracteatae 7, Arisaema Cum Bile 8, Pinellia leaven 5, Pericarpium Citri Reticulatae 4, Thallus Laminariae (Thallus Eckloniae) 2, Radix Platycodonis 11, Flos Impatientis 12, Semen Juglandis 2, Thallus Laminariae (Thallus Eckloniae) 2, Thallus Laminariae 2.
Prepare by the following method:
(1) Radix Ginseng, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Radix Ophiopogonis, Fructus Corni, Fructus Lycii, Fructus Schisandrae Chinensis, the Rhizoma Zingiberis co-grinding 1200kg that adds water after crossing 10 mesh sieves adopts dynamic successive stages countercurrent extraction 9 hours at 99 DEG C, and filter, extracting solution is for subsequent use;
(2) by the extracting solution that (1) obtains, be under the condition of 95 DEG C in normal pressure temperature, be condensed into dry cream, through micronizing, obtain the powder 13.65kg of particle diameter between 10 μm ~ 25 μm; Add Mel 7.65kg, obtain the pill 2130 of every 9g through molding, molding, capping.
experimental example 1
The animal acute toxicity test of Chinese medicine composition of the present invention
The present embodiment 2, by the mensuration of Mouse oral administration medicine median lethal dose(LD 50), has investigated the Chinese medicine composition of embodiment 2 preparation to the acute toxic reaction of mice and death condition.
Get mice 30, often organize 10, points 3 groups, be i.e. high, medium and low 3 dosage groups (0.8,0.4,0.2ml/15g) gastric infusion 3 times/day, the scope of prediction Calculating Median Lethal Dose of Drugs.Result shows, and high dose group does not measure median lethal dose(LD 50), therefore the mensuration of medicine gastric infusion median lethal dose(LD 50) is changed the mensuration doing maximum volume purgation maximum lane point-maximum tolerated dose.
Get mice 30, on an empty stomach after 12 hours, to predict selected 0.8ml/15g metering by only gastric infusion to animal subject 3 times/day, Continuous Observation 7 days.
Give in gavage and be subject to test product 24 hours, mice voluntary activity declines, and ingests, takes the photograph water minimizing; Within second day, voluntary activity is tending towards normal gradually, stool, urine no abnormality seen, and mice activity, food ration, body weight growth, feces etc. are all normal, observes test mice after expiring and all survives.
Observe after expiring and put to death whole test mice gross necropsy, find each important organ, after one's own heart, liver, spleen, lung, kidney, ovary, intestinal, stomach etc. change without obvious pathomorphism.
The maximum dosage-feeding result of the test of medicine gastric infusion shows: all without obvious toxic reaction after 30 mice administrations, also without dead in one week.Be 43.9g/kg d to recording maximum tolerated dose after mouse stomach administration medicine, as calculated by clinical one-tenth human oral dosage form 8.0g/60kg, then the mice gavage maximum tolerated dose on the one of this medicine is [(43.9g/kg) ÷ (8.0g/60kg) ≈ 329] times of clinical adult oral dose on the one.Illustrate that the safety of Chinese medicine composition of the present invention is good.
experimental example 2
The clinical observation on the therapeutic effect of medicine of the present invention
1, physical data
Accept out-patient's totally 120 examples for medical treatment, less than 25 years old 20 age example, 26 ~ 55 years old 76 example, more than 56 years old 24 example.
2, diagnostic criteria
The classical symptom of asthma is that cough, vapour lock, expectoration, rapid breathing, gurgling with sputum, sound are as dragsaw.
Not etc., cough, vapour lock, expectoration, sometimes sputum mixed with blood, serious does not cause tracheitis and lung tracheal rupture to asthmatics's occurrence degree, even can not walk for a long time, difficulty of topping bar, and severe patient daily life is also much troubled.
3, Therapeutic Method
Select above-mentioned experimental example 1 medicament, take to patient, every day 2 times, each 1 dose, decoction being taken warmly at twice.Within 30 days, be a course for the treatment of, take two courses for the treatment of continuously.
4, efficacy assessment standard
Effective: symptoms of asthma is fully recovered, recover normal;
Take a turn for the better: symptoms of asthma alleviates, and the state of an illness progressively takes a turn for the better;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form):
In above-mentioned treatment, by Drug therapy asthmatic patient 120 example of the present invention, effective 81 examples of result, obvious effective rate is 67.5%, and take a turn for the better 33 examples, and improvement rate is 27.5%, and invalid 6 examples, total effective rate is 95%.
In a word, a kind of pharmaceutical composition for the treatment of asthma of the present invention, for pure Chinese medicinal preparation, prescription is simplified, preparation method is simple, processing cost is low, evident in efficacy, without any side effects, the efficacy of a drug is strong, instant effect, can eliminate symptoms of asthma rapidly, adopt modern crafts pharmacy, the feature conveniently taken.
These are only the preferred embodiments of the present invention and experimental example, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (8)

1. treat the pharmaceutical composition of asthma for one kind, it is characterized in that, comprise: Radix Ginseng, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Radix Ophiopogonis, Fructus Corni, Fructus Lycii, Fructus Schisandrae Chinensis, Rhizoma Zingiberis, the Rhizoma Anemarrhenae, Bulbus Fritillariae Uninbracteatae, Arisaema Cum Bile, Pinellia leaven, Pericarpium Citri Reticulatae, Thallus Laminariae (Thallus Eckloniae), Radix Platycodonis, Flos Impatientis, Semen Juglandis, be made up of following weight parts: Radix Ginseng 1 part ~ 3 parts, Radix Achyranthis Bidentatae 2 parts ~ 6 parts, Radix Rehmanniae Preparata 5 parts ~ 10 parts, Radix Ophiopogonis 5 parts ~ 10 parts, Fructus Corni 3 parts ~ 6 parts, Fructus Lycii 1 part ~ 3 parts, Fructus Schisandrae Chinensis 1 part ~ 3 parts, Rhizoma Zingiberis 3 parts ~ 6 parts, the Rhizoma Anemarrhenae 5 parts ~ 10 parts, Bulbus Fritillariae Uninbracteatae 5 parts ~ 10 parts, Arisaema Cum Bile 5 parts ~ 10 parts, Pinellia leaven 3 parts ~ 6 parts, Pericarpium Citri Reticulatae 2 parts ~ 5 parts, 1 part ~ 3 parts, Thallus Laminariae (Thallus Eckloniae), Radix Platycodonis 10 parts ~ 13 parts, Flos Impatientis 11 parts ~ 13 parts, Semen Juglandis 1 part ~ 3 parts.
2. the pharmaceutical composition for the treatment of asthma according to claim 1, is characterized in that, its pharmaceutical composition also comprises: Thallus Laminariae (Thallus Eckloniae) 1 part ~ 3 parts, Thallus Laminariae 1 part ~ 3 parts.
3. the pharmaceutical composition for the treatment of asthma according to claim 2, it is characterized in that, its pharmaceutical composition weight portion consists of: Radix Ginseng 1 part, Radix Achyranthis Bidentatae 2 parts, Radix Rehmanniae Preparata 6 parts, Radix Ophiopogonis 7 parts, Fructus Corni 6 parts, Fructus Lycii 2 parts, Fructus Schisandrae Chinensis 1 part, Rhizoma Zingiberis 4 parts, the Rhizoma Anemarrhenae 8 parts, Bulbus Fritillariae Uninbracteatae 9 parts, Arisaema Cum Bile 10 parts, Pinellia leaven 6 parts, Pericarpium Citri Reticulatae 5 parts, 3 parts, Thallus Laminariae (Thallus Eckloniae), Radix Platycodonis 12 parts, Flos Impatientis 13 parts, Semen Juglandis 1 part, Thallus Laminariae (Thallus Eckloniae) 1 part, Thallus Laminariae 1 part.
4. a pharmaceutical composition for the treatment asthma as described in any one of claims 1 to 3, it is characterized in that, preparation method is as follows:
Step S01, the pure water adding 10 times ~ 20 times after Radix Ginseng, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Radix Ophiopogonis, Fructus Corni, Fructus Lycii, Fructus Schisandrae Chinensis, Rhizoma Zingiberis, the Rhizoma Anemarrhenae, Bulbus Fritillariae Uninbracteatae, Arisaema Cum Bile, Pinellia leaven, Pericarpium Citri Reticulatae, Thallus Laminariae (Thallus Eckloniae), Radix Platycodonis, Flos Impatientis, Semen Juglandis, Thallus Laminariae (Thallus Eckloniae), Thallus Laminariae co-grinding is adopted dynamic successive stages countercurrent extraction 6 hours ~ 10 hours under the condition of 95 DEG C ~ 100 DEG C, filter, extracting solution is for subsequent use;
Step S02, the extracting solution obtained by step S01, through super-dry, pulverizing, adds adjuvant, granulates, makes required dosage form.
5. the preparation method of the pharmaceutical composition for the treatment of asthma according to claim 4, it is characterized in that, in step S01, the condition pulverized after described Radix Ginseng, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Radix Ophiopogonis, Fructus Corni, Fructus Lycii, Fructus Schisandrae Chinensis, Rhizoma Zingiberis, the Rhizoma Anemarrhenae, Bulbus Fritillariae Uninbracteatae, Arisaema Cum Bile, Pinellia leaven, Pericarpium Citri Reticulatae, Thallus Laminariae (Thallus Eckloniae), Radix Platycodonis, Flos Impatientis, Semen Juglandis, Thallus Laminariae (Thallus Eckloniae), Thallus Laminariae mixing is: the medicinal mixture after pulverizing crosses 10 mesh sieves.
6. the preparation method of the pharmaceutical composition for the treatment of asthma according to claim 4, is characterized in that, in step S02, extracting solution through super-dry, pulverize after particle diameter between 10 μm ~ 25 μm.
7. the preparation method of the pharmaceutical composition of asthma according to claim 4, is characterized in that, in step S02, the mode of described extracting solution drying is: spraying dry, or vacuum drying, or vacuum lyophilization, or constant-pressure and high-temperature is dry.
8. the preparation method of the pharmaceutical composition for the treatment of asthma according to claim 4, is characterized in that, in step S02, the dosage form of described pharmaceutical composition is granule or pill or soft capsule or capsule or tablet.
CN201410563123.6A 2014-10-21 2014-10-21 Pharmaceutical combination for treating asthma and preparation method thereof Pending CN104353028A (en)

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Publication number Priority date Publication date Assignee Title
CN104740081A (en) * 2015-03-06 2015-07-01 姜新帅 Traditional Chinese medicine composition for treating viral hepatitis
CN104740153A (en) * 2015-03-06 2015-07-01 姜新帅 Traditional Chinese medicine composition for treating asthma
CN105797101A (en) * 2016-04-05 2016-07-27 林云权 Traditional Chinese medicine composition for treating constipation and preparation method of traditional Chinese medicine composition
WO2021235637A1 (en) * 2020-05-20 2021-11-25 남종현 Composition for prevention, alleviation, or treatment of respiratory disease
CN114728030A (en) * 2020-05-20 2022-07-08 南钟铉 Composition for preventing, alleviating or treating respiratory diseases
CN114728030B (en) * 2020-05-20 2024-02-09 南钟铉 Composition for preventing, alleviating or treating respiratory diseases

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Application publication date: 20150218