CN101708286B - Chinese patent medicament for treating sjogren's syndrome and intractable oral ulcer, and preparation method thereof - Google Patents
Chinese patent medicament for treating sjogren's syndrome and intractable oral ulcer, and preparation method thereof Download PDFInfo
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Abstract
The invention provides a Chinese patent medicament for treating sjogren's syndrome and intractable oral ulcer and provides a preparation method thereof. The Chinese patent medicament preferably comprises the following Chinese medicinal components in part by weight: 7 parts of fresh hawthorn fruit, 6 parts of Mongolian snakegourd foot, 6 parts of scrophularia, 6 parts of asparagus, 6 parts of cape jasmine fruit, 6 parts of cortex lycii radicis, 6 parts of rehmanniae praeparatum, 2 parts of bletilla, 6 parts of honeysuckle flower, 7 parts of dwarf lilyturf tuber, 7 parts of white paeony root, 1.8 parts of largetrifoliolious bugbane rhizome and 7 parts of medicated leaven. The Chinese patent medicament for treating the sjogren's syndrome and the intractable oral ulcer has the advantages of good effect, obvious curative effect and relapse prevention after medicament discontinuance; patients do not need taking medicaments for a long time for maintaining; and the Chinese patent medicament has no medicament resistance, toxic or side effects.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine that is used for the treatment of dry syndrome, intractable oral cavity ulcer and preparation method thereof.
Background technology
Dry syndrome, intractable oral cavity ulcer is that infringement external secretion body of gland is the autoimmune disease of characteristic based on the chronic inflammatory disease and the destruction of salivary gland and lachrymal gland especially, it is clinical that dry mouth and parching tongue often to occur dry and cracked, xerophthalmia scheorma, dental caries, parotitis of Fa Shenging etc. repeatedly, involve the clinical manifestation that other organs cause multiple diseases simultaneously, as xerostomia, tinnitus, constipation, laryngopharynx swelling and pain, gastric heat, the halitosis bitter taste, stomatocace, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, various disease conditions such as cough due to lung-heat, the oral ulcer their early stage, small rice grain sample blister appears in oral mucosa, form white ulcer behind the blister ulceration, pain is involved oral cavity portion and bottleneck throat inflammation is taken place unbearably.Data at home and abroad shows dry syndrome, the intractable oral cavity ulcer prevalence is 3～4%, and be considered to be only second to the commonly encountered diseases of rheumatoid arthritis, be one of 42 kinds of difficult diseases listing in of World Health Organization (WHO), dry syndrome, the Therapeutic Method of intractable oral cavity ulcer, the medicine of treatment primary disease is many with antibiotic both at home and abroad at present, hormone, immune formulation is main, above various kinds of drug can only be alleviated surface symptoms, curative effect is undesirable, and easily recurrence after the drug withdrawal, the patient has to take medicine for a long time and keeps, and then be easy to generate Drug resistance and other organ of infringement, so the medicine of a kind for the treatment of both the principal and secondary aspects of a disease of invention is treated this disease, become extensive patients and earnestly expected.
Summary of the invention
The object of the present invention is to provide a kind of Chinese patent medicine for the treatment of dry syndrome, intractable oral cavity ulcer, have that promoting digestion and invigorating the stomach, blood circulation promoting and blood stasis dispelling, suppressing the hyperactive liver relieving constipation, nourishing YIN and clearing away heat, promoting the production of body fluid for nourishing the lung, detoxifcation are held back skin ulcer, removing the necrotic tissue and promoting granulation, the removing heat from blood that quenches the thirst, reducing swelling and alleviating pain, removing heat-phlegm, moisturize and remove the effect of doing, improve the human body immunocompetence, adapt to social need, be more vast patient's service.
Another kind of purpose of the present invention provides a kind of preparation method for preparing this Chinese patent medicine.
The present invention, the Chinese patent medicine of treatment dry syndrome, intractable oral cavity ulcer, its Chinese medicine composition parts by weight proportioning is: 7～8 parts of Fructus Crataegi, 5.6～7 parts of Radix Trichosanthis, 5.6～6.8 parts of Radix Scrophulariae, 5.6～7 parts of Radix Asparagis, 5.6～6.8 parts of Fructus Gardeniaes, 5.6～6.8 parts of Cortex Lycii, 5.6～6.8 parts in the Radix Rehmanniae, 1.8～2.6 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 5.6～6.8 parts of Flos Loniceraes, 6.8～7.6 parts of Radix Ophiopogonis, 5.6～7 parts of the Radix Paeoniae Albas, 1.2～1.8 parts of Rhizoma Cimicifugaes, 5.6～7 parts of Massa Medicata Fermentata.
Further, the Chinese patent medicine of described treatment dry syndrome, intractable oral cavity ulcer, the best proportioning of its Chinese medicine composition parts by weight is: 7 parts of Fructus Crataegi, 6 parts of Radix Trichosanthis, 6 parts of Radix Scrophulariae, 6 parts of Radix Asparagis, 6 parts of Fructus Gardeniaes, 6 parts of Cortex Lycii, 6 parts in the Radix Rehmanniae, 2 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 6 parts of Flos Loniceraes, 7 parts of Radix Ophiopogonis, 7 parts of the Radix Paeoniae Albas, 1.8 parts of Rhizoma Cimicifugaes, 7 parts of Massa Medicata Fermentata.
The preparation method of the Chinese patent medicine of described treatment dry syndrome, intractable oral cavity ulcer, its preparation technology's method is:
1, the former material of above-mentioned Chinese medicine is selected decontamination, drying and sterilizing is pulverized and is ground, and is screened into 100～200 order fine powders, and fully mixing is standby.
2, Mel and Chinese medicine fine powder mixing and stirring that Chinese medicine fine powder gross weight is commensurability made honeyed pill.
The present invention, the Chinese patent medicine of treatment dry syndrome, intractable oral cavity ulcer has following beneficial effect:
1, through Clinical Laboratory, the present invention has that promoting digestion and invigorating the stomach, blood circulation promoting and blood stasis dispelling, suppressing the hyperactive liver relieving constipation, nourishing YIN and clearing away heat, promoting the production of body fluid for nourishing the lung, detoxifcation are held back skin ulcer, removing the necrotic tissue and promoting granulation, the removing heat from blood that quenches the thirst, reducing swelling and alleviating pain, removing heat-phlegm, moisturize and remove the effect of doing, microcirculation improvement, the human body immunity improving ability reduces complication.
2, be difficult for recurrence after effective, evident in efficacy, the drug withdrawal of Chinese patent drugs for treatment dry syndrome of the present invention, intractable oral cavity ulcer, the patient no longer needs to take for a long time medicine and keeps, and does not develop immunity to drugs, and safety non-toxic has no side effect.
The effect and the effect of the Main Ingredients and Appearance of Chinese patent medicine of the present invention are:
Fructus Crataegi: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis are used for the treatment of diseases such as meat stagnation, gastral cavilty distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain, hyperlipemia.
Radix Scrophulariae: heat clearing away, detoxifcation, yin nourishing are used for the treatment of diseases such as dryness of the lung dry cough, fever of the body xerostomia, laryngopharynx swelling and pain, carbuncle sore tumefacting virus, thromboangiitis obliterans, diabetic foot gangrene.
Fructus Gardeniae: the relieving restlessness that clears away heart-fire, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body are used for the treatment of diseases such as calentura is vexed, liver-fire conjunctival congestion, reducing swelling and alleviating pain, jaundice stranguria with blood.
The Radix Rehmanniae: sweet-bitter flavor, cold in nature and go into blood system, clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting are used for the treatment of diseases such as fever of the body xerostomia, heat in blood poison Sheng, consumption of YIN caused by febrile disease, thirsty polydipsia, dryness of the intestine constipation;
Flos Lonicerae: heat-clearing and toxic substances removing, wind-heat dissipating are used for the treatment of carbuncle furuncle, sore throat erysipelas, warm blood fulminant dysentery, diseases such as anemopyretic cold, epidemic febrile disease heating.
The Radix Paeoniae Alba: suppressing the hyperactive liver and subsiding YANG, the yin fluid astringing that nourishes blood, easing the affected liver to relieve pain are used for the treatment of diseases such as headache is dizzy, the fidgety irritability of tinnitus, interior-heat caused by deficiency of YIN aversion to wind, stagnation of QI due to depression of the liver.
Rhizoma Cimicifugae: deliver rash, heat-clearing and toxic substances removing, gas that the elevate a turnable ladder sun is clear, be used for the treatment of sinking of QI of middle-JIAO and headache due to pathogenic wind-heat, toothache aphtha, laryngopharynx swelling and pain, measles without adequate eruption, pyretic toxicity is sent out diseases such as speckle.
Radix Trichosanthis: clearing away heat and promoting production of body fluid, detumescence and apocenosis are used for the treatment of consumption of body fluid caused by febrile disease, xerostomia is thirsty, diseases such as lung-heat type cough, carbuncle skin infection.
Radix Asparagi: replenishing YIN and removing heat, lung moistening YIN nourishing are used for the treatment of diseases such as dryness of the lung dry cough, pertussis expectorant are glutinous, dry throat and mouth, dryness of the intestine constipation.
Cortex Lycii: sweet in the mouth, light, cold in nature, clearind deficient heat, removing heat from blood function are arranged, be used for the treatment of fever due to yin deficiency, night sweat, vexed, thirsty, lung-heat cough with asthma, spitting of blood, haematemesis, epistaxis, disease such as quench one's thirst.
The Pseudobulbus Bletillae (Rhizoma Bletillae): astringing to arrest bleeding, detumescence and promoting granulation are used for the treatment of carbuncle malignant boil, the dead flesh of impairment of YIN, hemostasis antacid etc.
Radix Ophiopogonis: yin nourishing stomach reinforcing, lung moistening clear away heart-fire, and are used for the treatment of xerostomia, the few expectorant of cough, are hard and dry, disease such as dysphoria and insomnia.
Massa Medicata Fermentata: the effect of warming middle-JIAO QI invigorating, hot loose circulation of qi promoting, the stomach function regulating that helps digestion is arranged, be used for the treatment of eating accumulation, distension and fullness in the abdomen, the indigestion and loss of appetite grade of lack of appetite disease.
Mel: loosening bowel to relieve constipation, nourishing the lung to arrest cough, tonifying the stomach and spleen is in harmonious proportion the property of medicine, cures mainly the diseases such as the hot-tempered constipation of intestinal, dryness of the lung dry cough dry pharynx of impairment of body fluid.
This medicinal application example:
1, Wang Jinglei: the man, 75 years old, the 23rd group of cypress mountain village, Boai County, inquiring patient headache and insomnia, xerosis cutis, cheilosis are had a surplus half a year, do not have other disease at ordinary times, through taking other related drugs, do not see positive effect.Use this agent, every day 3 times, each 9 grams, symptom slowly disappears after three days, and the insomnia headache alleviates, and adds 2 days, and all diseases in clothes back are taken a turn for the better, and heal entirely after 2 days continue clothes, pay a return visit after 1 year and do not see recurrence.
2, Wang Pingan: the man, 58 years old, the 18th group of cypress mountain village, patient becomes thin, lack of appetite, dry cough are unable, uncomfortable in chest, normal insomnia and dreamful sleep, easily frightened, vexed, hungry and do not have appetite, through taking medicine 5 days, every day 3 times, each 9 restrain, all diseases slowly alleviate, and continue clothes recovery from illness after 3 days, pay a return visit after half a year and do not see recurrence.
3, Liu Zhuan: man, 48 years old, insomnia, headache and dizzy, blood pressure is at 100-180, patient's tongue fur is yellowish-brown, bitter taste in the mouth and dry throat, Sublingual are covered with sporadic blister, congested redness appears in bottleneck throat, can not normally take food, yellow urine is few, be hard and dry, and belongs to the disease of liver-fire rising, disarmony between the heart and kidney, through taking this medicament, every day 3 times, each 9 grams after taking medicine 6 days, are had a blood test and are pressed 80-140, all diseases are taken a turn for the better, and clothes recovery from illness in 3 days continues.
4, Wang Ziyu: woman, 10 months, two groups of cypress mountain villages, the patient coughs because of hyperpyrexia, gives the antibiotic therapy commentaries on classics of not getting better in 4 days through transfusion, goes to a doctor in the here of coming, the inspection lip is little to be done, and patient's tongue body is covered with sporadic prickle, has begun diabrosis and has formed ulcer, the temperature of having a medical check-up 40 degree, the patient cries and screams unbearably, and can not fall asleep night, cough, vomiting, loss of appetite, defecate and do not separate in 6th, this disease is that hyperactivity of heart-fire causes vexed uneasiness, the lung qi of burning, cough due to lung-heat, lung not respectful falling and cause the vomiting and big functional disorder of intestine cause constipation, through taking each 1.5 grams of powder of the present invention, each 3 times, taking medicine began defecation in second day, body temperature drops to 37 degree, heals entirely after three days.
5, Wang Shikang: man, 7 years old, Jiaozuo City Central Region family members institute of machinery plant, the patient is because of high fever, merge the acute pharyngolaryngitis hospitalization, after 7 days, sx is left hospital through antibiotic therapy, after 3 days, hyperpyrexia repeated to take place, cough, tell the sticking expectorant of little yellow, the temperature of having a medical check-up 39 degree, patient's flushed complexion, tongue body is covered with sporadic sesame thorn of needle point sample and blister, the visible diabrosis of part forms ulcer, and this is a hyperactivity of heart-fire, the taste of burning, spleen is fortune not, and cause damp and hot pathogen, be stranded impairment of the spleen soil, take Chinese patent medicine of the present invention, every day 2 times, each 3 grams, after taking medicine 3 days, bean dregs sample times of defecation reduces, and all diseases alleviate, continue and obeyed 2 days, complete.
6, Wang Douren, man, 70 years old, 28 groups of cypress mountain villages, consultation time are in August, 09, and the patient is because of xerostomia dryness in the nasal cavity, the concurrent sublingual ulcer of dry laryngopharynx was once gone to a doctor in certain institute, awarded antibiotic therapy 7 days through transfusion, the commentaries on classics of not getting better, inspection is gone to a doctor in the here that stops to infuse afterwards, red tongue, the little Huang of tongue fur is hyperactivity of deficient fire, how empty prolonged illness is, and the deficiency of body fluid performance is observed the Sublingual and found to have the ulcer diffusion, the lingualis diseased region has poroma, swells and ache unbearably, can not normally take food, take Chinese patent medicine of the present invention, every day 3 times, each 9 grams, obeyed altogether 5 days, above-mentioned symptom alleviates, and continues and obeys 2 days, complete, more pay a return visit February the back, does not see recurrence.
7, Wang Laokai, the man, 56 years old, 30 groups of cypress mountain villages began morbidity in 2007, to the autumn and winter in 2008, annual autumn and winter season whole body hop to it and itch, unbearably fidgety, invalid through seeing the doctor for treatment in many ways, come to go to a doctor in JIUYUE, 09, the main suit does not have other disease usually.Take Chinese patent medicine of the present invention, every day 3 times, each 9 grams were taken 5 days altogether, and the patient is healed entirely, pays a return visit after February and does not see recurrence.
Medical effect contrast clinical observation according to the conditions of patients situation, is divided into 4 groups, every group 12 people.
First group, the 3rd group is used antibiotic, hormone, immune formulation treatment.
Take this agent treatment for second group, the 4th group.
Symptom total effects table
Using method: adult every day three times, each 9 grams.The medical effect evaluation criteria is: all remissions are effectively, all transference cures, and non-relapse after healing is recovery from illness.
The result shows that first and third group of state of an illness of using the said method treatment to observe the patient after three months can only be controlled, can not heal entirely, often recurrence.The second, four groups are used this agent, and the state of an illness of observing the patient after three months can thoroughly be cured and do not recurred.
Because of containing Radix Trichosanthis Saponin albumen in the Chinese patent medicine of the present invention, cause that easily the anemia of pregnant woman miscarries, so anemia of pregnant woman's forbidding, Deficiency and coldness of spleen and stomach and diarrhea person avoid usefulness, avoid pungent food.
Usage: 2～3 times on the one, one time 9 gram, one time 18 gram of patient with severe symptoms, the suitable decrement of child.
The specific embodiment
Embodiment 1: be used for the treatment of the Chinese patent medicine of dry syndrome, intractable oral cavity ulcer, the best proportioning of its Chinese medicine composition parts by weight is: 7 parts of Fructus Crataegi, 6 parts of Radix Trichosanthis, 6 parts of Radix Scrophulariae, 6 parts of Radix Asparagis, 6 parts of Fructus Gardeniaes, 6 parts of Cortex Lycii, 6 parts in the Radix Rehmanniae, 2 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 6 parts of Flos Loniceraes, 7 parts of Radix Ophiopogonis, 7 parts of the Radix Paeoniae Albas, 1.8 parts of Rhizoma Cimicifugaes, 7 parts of Massa Medicata Fermentata.
Embodiment 2: the preparation method of the Chinese patent medicine of treatment dry syndrome, intractable oral cavity ulcer, its preparation technology's method is: (1), the former material of above-mentioned Chinese medicine is selected decontamination, drying and sterilizing is pulverized and is ground, and is screened into 100～200 order fine powders, fully mixing.
(2), Mel and Chinese medicine fine powder mixing and stirring that Chinese medicine fine powder gross weight is commensurability, make honeyed pill.
Claims (3)
1. one kind is used for the treatment of dry syndrome, the Chinese patent medicine of intractable oral cavity ulcer, it is characterized in that: the Fructus Crataegi that with the parts by weight proportioning is 7～8 parts, 5.6～7 parts Radix Trichosanthis, 5.6～6.8 parts Radix Scrophulariae, 5.6～7 parts Radix Asparagi, 5.6～6.8 parts Fructus Gardeniae, 5.6～6.8 parts Cortex Lycii, 5.6～6.8 parts the Radix Rehmanniae, 1.8～2.6 parts the Pseudobulbus Bletillae (Rhizoma Bletillae), 5.6～6.8 parts Flos Lonicerae, 6.8～7.6 parts Radix Ophiopogonis, 5.6～7 parts the Radix Paeoniae Alba, 1.2～1.8 parts Rhizoma Cimicifugae, 5.6～7 parts Massa Medicata Fermentata is selected decontamination, drying and sterilizing, pulverize and grind, be screened into 100～200 order fine powders, fully mixing; Mel that Chinese medicine fine powder gross weight is commensurability and Chinese medicine fine powder mixing and stirring are made honeyed pill.
2. the Chinese patent medicine that is used for the treatment of dry syndrome, intractable oral cavity ulcer according to claim 1 is characterized in that: wherein 7 parts of Fructus Crataegi, 6 parts of Radix Trichosanthis, 6 parts of Radix Scrophulariae, 6 parts of Radix Asparagis, 6 parts of Fructus Gardeniaes, 6 parts of Cortex Lycii, 6 parts in the Radix Rehmanniae, 2 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 6 parts of Flos Loniceraes, 7 parts of Radix Ophiopogonis, 7 parts of the Radix Paeoniae Albas, 1.8 parts of Rhizoma Cimicifugaes, 7 parts of Massa Medicata Fermentata.
3. the preparation method of the Chinese patent medicine of claim 1 or 2 described treatment dry syndromes, intractable oral cavity ulcer, it is characterized in that: Fructus Crataegi, Radix Trichosanthis, Radix Scrophulariae, Radix Asparagi, Fructus Gardeniae, Cortex Lycii, the Radix Rehmanniae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Lonicerae, Radix Ophiopogonis, the Radix Paeoniae Alba, Rhizoma Cimicifugae, the Massa Medicata Fermentata of described parts by weight proportioning are selected decontamination, drying and sterilizing, pulverize and grind, be screened into 100～200 order fine powders, fully mixing; Mel that Chinese medicine fine powder gross weight is commensurability and Chinese medicine fine powder mixing and stirring are made honeyed pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102272989A CN101708286B (en) | 2009-12-04 | 2009-12-04 | Chinese patent medicament for treating sjogren's syndrome and intractable oral ulcer, and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009102272989A CN101708286B (en) | 2009-12-04 | 2009-12-04 | Chinese patent medicament for treating sjogren's syndrome and intractable oral ulcer, and preparation method thereof |
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| CN101708286B true CN101708286B (en) | 2011-04-20 |
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| CN102688462B (en) * | 2012-05-08 | 2014-04-09 | 安徽智远生物科技有限公司 | Traditional Chinese medicinal composition for treating oral ulcer and preparation method thereof |
| CN102743577A (en) * | 2012-07-09 | 2012-10-24 | 南京中医药大学 | Traditional Chinese medicine composite for promoting expression of aquaporin-5 (AQP5) and preparation method and application of traditional Chinese medicine composite |
| CN104225234A (en) * | 2014-09-28 | 2014-12-24 | 山东青岛中西医结合医院 | Yin-nourishing and heat-clearing soup for treating sicca syndrome |
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