CN101584797B - Application of traditional Chinese medicine composition in preparing medicament for treating climacteric syndrome - Google Patents
Application of traditional Chinese medicine composition in preparing medicament for treating climacteric syndrome Download PDFInfo
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Abstract
The invention discloses application of a traditional Chinese medicine composition in preparing a medicament for treating climacteric syndrome. The traditional Chinese medicine composition contains rehmannia, frutus cnidii and the like; through clinical and animal experimentations, the medicament treats climacteric syndrome with obvious effect and little side effect, and is suitable for the clinical application.
Description
Technical field
The present invention relates to the application of a kind of Chinese medicine composition in preparation treatment climacteric syndrome medicine, belong to the Chinese herbal and crude drugs preparations technical field.
Background technology
Climacteric syndrome is that the women is before and after menopause, because ovarian function fails to stopping gradually, causes that body endocrine environment changes, thereby a series of of appearance are main syndrome with the autonomic nervous dysfunction.There are some researches show that climacteric women wherein has 1/3 women to spend and no conscious sympton smoothly approximately, and light heavy long or short symptom appears in 2/3 women.Gently then show as susceptible to lose temper due to restlessness, anxious state of mind, often influence the family life harmony; Heavy then merge other diseases and cause being unable to leave the bed, the forfeiture self care ability increases endless worry and living burden to the household.Because the women occurs symptom repeatedly and reached 5-10 surplus year, along with the process of social senilization, this problem more and more receives the attention of medical circle, how to address this problem, and has become one of research emphasis of medical circle.
Modern medicine treatment climacteric syndrome is used also the particularly estrogenic alternative medicine of gonadal hormone the most effectively the most always, but the side effect of this therapy is more, as causes metrorrhagia etc.
The present invention is the improvement invention of on the basis of 02146569.X patent, carrying out, and quotes in full the content of this patent document record at this.The application of unexposed this Chinese medicine composition of above-mentioned patent in the treatment climacteric syndrome.
Summary of the invention
Technical problem to be solved by this invention provides a kind of natural plant that adopts to be formed, and side reaction is few, the compound Chinese medicinal preparation of treatment menopausal syndrome evident in efficacy.
The present invention relates to a kind of new purposes of Chinese medicine composition, particularly, relate to the application of a kind of Chinese medicine composition in preparation treatment climacteric syndrome medicine.Chinese medicine according to the invention can be had the Chinese medicine of same or similar effect to replace, and these medical materials all can be concocted according to " national Chinese medicine processing standard " or " Chinese medicine voluminous dictionary ".
This Chinese medicine composition of treatment menopausal syndrome disclosed by the invention is that the crude drug that comprises following weight portion ratio is processed:
Semen Cuscutae 150-350 Fructus Lycii 100-200 Fructus Schisandrae Chinensis 30-60 Fructus Cnidii 20-50
Fructus Rosae Laevigatae 20-50 Fructus Rubi 20-50 Semen Allii Tuberosi 20-50 Radix Morindae Officinalis 20-50
Herba Cistanches 20-50 Radix Rehmanniae 30-60 Radix Cyathulae 20-50 Herba Epimedii 40-100
Radix Ginseng 15-35 Cornu Cervi Pantotrichum 10-25 Hippocampus 10-30 Fructus Toosendan 15-35.
The weight ratio of crude drug is preferably in the Chinese medicine composition of the present invention:
20 parts of 60 parts of Fructus Cnidiis of 100 parts of Fructus Schisandrae Chinensis of 350 parts of Fructus Lycii of Semen Cuscutae
20 parts of 50 parts of Radix Morindae Officinaliss of 20 parts of Semen Allii Tuberosi of 50 portions of Fructus Rubies of Fructus Rosae Laevigatae
40 parts of 50 parts of Herba Epimedii of 30 portions of Radix Cyathulaes of 50 portions of Radix Rehmanniae of Herba Cistanches
15 parts of 0 part of Fructus Toosendans of 10 parts of hippocampus 3s of 35 parts of Cornu Cervi Pantotrichums of Radix Ginseng.
Or:
46 parts of 70 parts of Fructus Schisandrae Chinensis of 138 parts of Herba Epimedii of 250 parts of Fructus Lycii of Semen Cuscutae
35 parts of 35 parts of Semen Allii Tuberosi of 35 portions of Fructus Rubies of 35 portions of Fructus Rosae Laevigatae of Fructus Cnidii
35 parts of 46 portions of Radix Cyathulaes of 35 portions of Radix Rehmanniae of 35 parts of Herba Cistanches of Radix Morindae Officinalis
23 parts of 21 parts of Fructus Toosendans of 16 portions of Hippocampus of 25 parts of Cornu Cervi Pantotrichums of Radix Ginseng.
Or:
50 parts of 30 parts of Fructus Cnidiis of 200 parts of Fructus Schisandrae Chinensis of 150 parts of Fructus Lycii of Semen Cuscutae
50 parts of 20 parts of Radix Morindae Officinaliss of 50 parts of Semen Allii Tuberosi of 20 portions of Fructus Rubies of Fructus Rosae Laevigatae
100 parts of 20 parts of Herba Epimedii of 60 portions of Radix Cyathulaes of 20 portions of Radix Rehmanniae of Herba Cistanches
35 parts of 10 parts of Fructus Toosendans of 25 portions of Hippocampus of 15 parts of Cornu Cervi Pantotrichums of Radix Ginseng.
The pharmaceutical composition of described treatment climacteric syndrome, its form also can comprise the Radix Astragali, Radix Scrophulariae, the Cortex Eucommiae, Solenognathus, Cordyceps, Testis et penis callorhini, Endoconcha Sepiae, Ootheca Mantidis, Semen Euryales, Rhizoma Dioscoreae, Radix Dipsaci, Radix Rehmanniae Preparata, Semen Nelumbinis wherein one or more.
The preparation of drug combination method of above-mentioned treatment climacteric syndrome comprises:
A, take by weighing Chinese crude drug, clean according to the crude drug part by weight;
B, get Fructus Cnidii, Semen Cuscutae, Fructus Schisandrae Chinensis, Herba Epimedii and add 6-10 and doubly measure 60-80% ethanol, reflux, extract, 1-3 time, each 1-3 hour, filter, collecting decoction, decompression recycling ethanol is to there not being the alcohol flavor, and is subsequent use;
Medical material residue and merging after c, Fructus Lycii, Radix Rehmanniae, Fructus Rubi, Fructus Rosae Laevigatae, Semen Allii Tuberosi, Radix Morindae Officinalis, Fructus Toosendan and the alcohol extraction; Add water 6-10 and doubly measure decoction 1-3 time; Each 1-3 hour, filter merging filtrate; Mix with step (b) gained alcohol extract, measuring relative density during 60 ℃ of simmer down tos is the clear paste of 1.25-1.30;
D, Radix Ginseng, Cornu Cervi Pantotrichum, Hippocampus, Herba Cistanches, Radix Cyathulae are ground into fine powder;
Step c gained clear paste and steps d gained fine powder constitute the active component of Chinese medicine composition of the present invention jointly.
The preparation of drug combination method step (c) of described treatment climacteric syndrome, the mixture that (d) processes can be used for preparing clinically the base stock of tablet, electuary, powder.
Other dosage forms of medicine of the present invention are in proportion after the weighting raw materials; Adopt conventional method for preparing preparation; For example, the preparation technology of Fan Biting " pharmacy of Chinese materia medica " (Shanghai Science Press 1997 December the 1st edition) record processes the acceptable regular dosage form of pharmaceutics.
For above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, PEG4000, insect wax etc.For making above-mentioned dosage form can realize pharmacy of Chinese materia medica, need when these dosage forms of preparation, to add acceptable other adjuvant of pharmacy (adjuvant of each dosage form record among the Fan Biting " pharmacy of Chinese materia medica ", Shanghai Science Press December in 1997 the 1st edition).
Dosage form of the present invention is capsule, tablet, powder, oral liquid, soft capsule, pill, tincture, syrup, suppository, gel, spray or injection.
Preferably, the method for preparing of capsule of the present invention is:
A, take by weighing Chinese crude drug, clean according to the crude drug part by weight;
B, get Fructus Cnidii, Semen Cuscutae, Fructus Schisandrae Chinensis, Herba Epimedii and add 6-10 and doubly measure 60-80% ethanol, reflux, extract, 1-3 time, each 1-3 hour, filter, collecting decoction, decompression recycling ethanol is to there not being the alcohol flavor;
Medical material residue and merging after c, Fructus Lycii, Radix Rehmanniae, Fructus Rubi, Fructus Rosae Laevigatae, Semen Allii Tuberosi, Radix Morindae Officinalis, Fructus Toosendan and the alcohol extraction; Add water 6-10 and doubly measure decoction 1-3 time; Each 1-3 hour, filter merging filtrate; Mix with step (b) gained alcohol extract, measuring relative density during 60 ℃ of simmer down tos is the clear paste of 1.25-1.30;
D, Radix Ginseng, Cornu Cervi Pantotrichum, Hippocampus, Herba Cistanches, Radix Cyathulae are ground into fine powder;
E, with steps d gained fine powder and step c gained clear paste mixing and stirring, oven dry is pulverized, and incapsulates, and promptly gets.
By motherland's traditional medical theory analysis, climacteric syndrome belongs to " all diseases before and after the menopausal women " category, before and after the menopausal women, and the kidney qi degradation, asthenia of essence and blood, dashing a hypofunction is the main cause that causes a series ofization symptom.Its sick position is at kidney, and the conscience that relates to reaches towards conception vessel, and modal pathomechanism is: deficiency of kidney yin, hyperactivity of hesrt-fire and liver-fire." element ask ancient times innocent opinion " cloud: " woman, seventy-seven, conception vessel is empty, and taichong channel declines few, exhaustion of kidney-essence with promoting reproductive function, menopause is so senile appearance and loss of fecundity are also." " Yizong Jinjian gynecological heart method gist ": " married woman's seventy-seven exhaustion of kidney-essence with promoting reproductive function constantly do not have disease blood and have a surplus; Oneself breaks and examines its event again, and evil sick being concerned with cures with demonstrate,proving " etc.It is cloudy smart that menses belongs to, and menses gradually exhausts, and kidney yin makes sees deficiency, deficiency of kidney yin, and the moon is YANG hyperactivity suppressing not, makes the disease that causes hyperactivity of YANG due to deficiency of YIN, the clinical common disease that hyperactivity of fire caused by deficiency of YIN such as paroxysmal is warmed, restless irritability, dizziness headache, tinnitus, soreness of the waist and knees, dry mouth with bitter taste are arranged.
The present invention is the rule of treatment with nourishing the liver and kidney, heat clearing away suppressing the hyperactive liver, mind tranquilizing and the heart calming, and all medicines both share and can nourish kidney yin in the prescription, but mind tranquilizing and the heart calming again.Play the merit of nourishing the liver and kidney, heat clearing away suppressing the hyperactive liver, mind tranquilizing and the heart calming altogether.Finally reach the curative effect of treatment climacteric syndrome.
Among the present invention, Chinese medicine composition of the present invention can be used for preparing the application in the various symptom medicines of alleviating climacteric syndrome.
Be preferably Chinese medicine composition of the present invention and improve the application in the climacteric women ovary endocrine function medicine in preparation.
Or:
Chinese medicine composition of the present invention improves the application in insomnia and dreamful sleep that climacteric syndrome causes, hectic fever hyperhidrosis, sore waist and aching in the waist and the back, hypomnesis, dizziness and tinnitus, irritated irritability, the abnormal emotion-thought medicine in preparation.
The consumption of Chinese medicine composition of the present invention by active component crude drug gross weight, is 7-28 gram/day, but takes every day once, preferably divides and takes for 2-4 time.
The specific embodiment
Below in conjunction with the instance of drug regimen of the present invention, the specific embodiment of the present invention is described.
Embodiment 1:
Semen Cuscutae 250g Fructus Lycii 138g Herba Epimedii 70g Fructus Schisandrae Chinensis 46g
Fructus Cnidii 35g Fructus Rosae Laevigatae 35g Fructus Rubi 35g Semen Allii Tuberosi 35g
Radix Morindae Officinalis 35g Herba Cistanches 35g Radix Rehmanniae 46g Radix Cyathulae 35g
Radix Ginseng 25g Cornu Cervi Pantotrichum 16g Hippocampus 21g Fructus Toosendan 23g
Method for preparing:
(1), get Fructus Cnidii 35g, Semen Cuscutae 250g, Fructus Schisandrae Chinensis 46g, Herba Epimedii 70g, add 8 times of amount 70% ethanol, reflux, extract, 2 times, each 2 hours, filter, collecting decoction, decompression recycling ethanol is not to there being the alcohol flavor, residue is subsequent use;
(2), the medical material residue after the alcohol extraction and Fructus Lycii 138g, Radix Rehmanniae 46g, Fructus Rubi 35g, Fructus Rosae Laevigatae 35g, Semen Allii Tuberosi 35g, Radix Morindae Officinalis 35g, Fructus Toosendan 23g are merged; Adding 9 times of amounts of water decocts twice; Each 2 hours, filter merging filtrate; Mix with step (1) alcohol extract, be evaporated to the clear paste of relative density 1.25-1.30 (60 ℃);
(3), Radix Ginseng 25g, Cornu Cervi Pantotrichum 16g, Hippocampus 21g, Herba Cistanches 35g, Radix Cyathulae 35g be ground into fine powder, with above-mentioned clear paste mix homogeneously, 65-70 ℃ of oven dry, pulverizes, and sieves, encapsulatedly promptly get.
Oral, one time 2,3 times on the one.
Embodiment 2,
Semen Cuscutae 350g Fructus Lycii 100g Fructus Schisandrae Chinensis 60g Fructus Cnidii 20g
Fructus Rosae Laevigatae 50g Fructus Rubi 20g Semen Allii Tuberosi 50g Radix Morindae Officinalis 20g
Herba Cistanches 50g Radix Rehmanniae 30g Radix Cyathulae 50g Herba Epimedii 40g
Radix Ginseng 35g Cornu Cervi Pantotrichum 10g hippocampus 3 0g Fructus Toosendan 15g.
Method for preparing:
(1), take by weighing Chinese crude drug, clean according to the crude drug part by weight;
(2), get Fructus Cnidii, Semen Cuscutae, Fructus Schisandrae Chinensis, Herba Epimedii, add 6 times of amount 60% ethanol, reflux, extract, 1 time, 3 hours, filter, collecting decoction, decompression recycling ethanol is not to there being the alcohol flavor, residue is subsequent use;
(3), the medical material residue after the alcohol extraction and Fructus Lycii, Radix Rehmanniae, Fructus Rubi, Fructus Rosae Laevigatae, Semen Allii Tuberosi, Radix Morindae Officinalis, Fructus Toosendan are merged; Adding 6 times of amounts of water decocts 1 time; 3 hours, filter merging filtrate; Mix with step (1) alcohol extract, be evaporated to the clear paste of relative density 1.25-1.30 (60 ℃);
(4), Radix Ginseng, Cornu Cervi Pantotrichum, Hippocampus, Herba Cistanches, Radix Cyathulae be ground into fine powder, with above-mentioned clear paste mix homogeneously, 65-70 ℃ of oven dry, pulverizes, and sieves, and processes tablet by the conventional formulation method.
Embodiment 3,
Semen Cuscutae 150g Fructus Lycii 200g Fructus Schisandrae Chinensis 30g Fructus Cnidii 50g
Fructus Rosae Laevigatae 20g Fructus Rubi 50g Semen Allii Tuberosi 20g Radix Morindae Officinalis 50g
Herba Cistanches 20g Radix Rehmanniae 60g Radix Cyathulae 20g Herba Epimedii 100g
Radix Ginseng 15g Cornu Cervi Pantotrichum 25g Hippocampus 10g Fructus Toosendan 35g.
Method for preparing:
(1), take by weighing Chinese crude drug, clean according to the crude drug part by weight;
(2), get Fructus Cnidii, Semen Cuscutae, Fructus Schisandrae Chinensis, Herba Epimedii, add 10 times of amount 80% ethanol, reflux, extract, 3 times, each 2 hours, filter, collecting decoction, decompression recycling ethanol is not to there being the alcohol flavor, residue is subsequent use;
(3), the medical material residue after the alcohol extraction and Fructus Lycii, Radix Rehmanniae, Fructus Rubi, Fructus Rosae Laevigatae, Semen Allii Tuberosi, Radix Morindae Officinalis, Fructus Toosendan are merged; Adding 10 times of amounts of water decocts 3 times; Each 1 hour, filter merging filtrate; Mix with step (1) alcohol extract, be evaporated to the clear paste of relative density 1.25-1.30 (60 ℃);
(4), Radix Ginseng, Cornu Cervi Pantotrichum, Hippocampus, Herba Cistanches, Radix Cyathulae be ground into fine powder, with above-mentioned clear paste mix homogeneously, 65-70 ℃ of oven dry processed pill by the conventional formulation method.
For confirming the curative effect of Drug therapy climacteric syndrome of the present invention, use the capsule (to call medicine of the present invention in the following text) that makes by embodiment, carried out following clinical experimental study:
Embodiment 4:
Medicine composite for curing climacteric syndrome of the present invention clinical trial
For illustrating the activity of traditional Chinese medicine composition for treating climacteric syndrome of the present invention, use the capsule (to call medicine of the present invention in the following text) that makes by the foregoing description 1 method to carry out following clinical trial.
1, clinical data
1.1 physical data 102 routine patients are Hebei Yi Ling hospital outpatient case, are divided into treatment group and matched group at random, 53 examples are organized in treatment, age 41-57 year; On average (47.6 ± 3.3) year, the course of disease was less than 1 year person's 29 example, and 1-5 person's 18 examples were greater than 5 years person's 6 examples; Matched group 49 examples, age 40-57 year, average (47.3 ± 2.7) year, the course of disease was less than 1 year person's 28 example; 1-5 person's 15 examples, greater than 5 years person's 6 examples, two groups at aspect there was no significant differences (P＞0.05) such as age, the state of an illness, the courses of disease, had comparability.
1.2 the female climacteric syndrome diagnostic criteria of diagnostic criteria reference " new Chinese medicine clinical research guideline " (the 3rd volume) is drafted.(1) age is at 40-60 between year; (2) symptom has the sweating of warming except that the menstruation imbalance, and hectic fever is flushing, dizziness and tinnitus, feverish sensation in the palms and soles, irritated irritability, palpitation and insomnia, abnormal emotion-thought, hypomnesis, fluctuation of blood pressure etc.; (3) make preparation for ploughing and sowing the table E
2Level descends, and FSH, LH level raise.
2, Therapeutic Method
2.1 the treatment group gives medicine of the present invention, one time 4,3 times on the one.
2.2 matched group gives female precious ball each 6 grams, 3 times on the one, two groups was 1 course of treatment with 2 months all, the other drug of stopping using during the treatment.
2.3 observation index
Observe palpitation and restlessness before and after the course of treatment, shortness of breath and fatigue, chest is vexed painful, insomnia and dreamful sleep, tcm syndromes such as tongue fur pulse condition, inspection such as 24 hr Ambulatory EKG Monitoring (Holter) index.
Laboratory detects index: serum E2, FSH, LH, all adopt the electrochemiluminescence immunoassay, and test kit is provided by U.S. Roche Holding Ag.
2.4 the statistical method enumeration data is used χ
2Check, measurement data is checked with t.
3, observation of curative effect
3.1 criterion of therapeutical effect
Tcm syndrome criterion of therapeutical effect: should adopt 1-6 to divide the sxemiquantitative integration method to the influence degree of working, live according to clinical main syndromes such as palpitation and restlessness, shortness of breath and fatigue, suffocating pain over the chest, spiritlessness and too weak to speak, insomnia and dreamful sleep, picture of the tongue pulse conditions.Efficacy determination adopts the nimodipine method.Be divided into clinical recovery: original symptom, sign disappear basically, and total mark reduces >=90%; Produce effects: original symptom, sign major part disappear or obviously alleviate, and total mark reduces >=70%; Effectively: original symptom, sign alleviate before the treatment, and total mark reduces between 30-70%; Invalid: original symptom, sign do not have improvement, and total mark reduces＜30%.
3.2 therapeutic outcome: see table 1, treatment group total effective rate 93.75%, matched group total effective rate 89.58%, difference has significance meaning (P＜0.05).
Table 1 liang group clinical efficacy relatively
3.3 E2, FSH, LH change and see table 2 before and after the treatment, treatment group treatment back E2 level obviously increases, and before the treatment significant difference (P＜0.05) is arranged relatively; With significant difference (P＜0.05) is relatively arranged after the treatment of control group.Two groups of FSH and LH all do not see significant change (P＞0.05).
FSH, LH and E2 comparison before and after table 2 treatment (x ± s)
Annotate: contrast before and after the treatment of treatment group
*P＜0.05 is with contrast △ P＜0.05 after the treatment of control group.
4, conclusion
With the checking of mountain range hospital, take all diseases in this product treatment menopause front and back through Hebei Medical University, clinical efficacy is very satisfied.Evidence treatment group obviously is superior to matched group, and statistical test shows that curative effect has highly significant difference (0.01＞P＞0.005) between two groups.From the cardinal symptom improvement situation of treatment front and back, the treatment group has good improvement effect, and especially better to the curative effect of hectic fever sweating, insomnia, agitation or depression, soreness of the waist and knees etc., its total effective rate is about 85%.Show that this medical instrument has good nourishing the liver and kidney, heat clearing away suppressing the hyperactive liver, mind tranquilizing and the heart calming and regulates the effect of function of human body.This medicine is taken safe ready to without any side effects and untoward reaction of main organs such as the heart, liver, kidneys, and the patient takes like a shot, and has safety preferably.
The Chinese medicine preparation that the present invention treats menopausal syndrome adopts the natural plant prescription to form; Theoretical according to Chinese traditional treatment; Prescription has rationally overcome the easy shortcoming that produces serious side reaction, patient tolerability difference of doctor trained in Western medicine hormone therapy, is the new formulation of a kind of determined curative effect, safe ready.
Claims (8)
1. the application of Chinese medicine composition in the medicine of preparation treatment climacteric syndrome is characterized in that it being to be processed by following raw medicaments in portion by weight:
2. application according to claim 1 is characterized in that the weight portion proportioning of the crude drug of said Chinese medicine composition is:
Semen Cuscutae 350 Fructus Lycii 100 Fructus Schisandrae Chinensis 60 Fructus Cnidiis 20 Fructus Rosae Laevigatae 50
Fructus Rubi 20 Semen Allii Tuberosi 50 Radix Morindae Officinaliss 20 Herba Cistanches 50 Radix Rehmanniae 30
Radix Cyathulae 50 Herba Epimedii 40 Radix Ginsengs 35 Cornu Cervi Pantotrichums 10 hippocampus 3s 0 Fructus Toosendan 15.
3. application according to claim 1 is characterized in that the weight portion proportioning of the crude drug of said Chinese medicine composition is:
Semen Cuscutae 250 Fructus Lycii 138 Herba Epimedii 70 Fructus Schisandrae Chinensis 46 Fructus Cnidiis 35
Fructus Rosae Laevigatae 35 Fructus Rubies 35 Semen Allii Tuberosi 35 Radix Morindae Officinaliss 35 Herba Cistanches 35
Radix Rehmanniae 46 Radix Cyathulaes 35 Radix Ginsengs 25 Cornu Cervi Pantotrichums 16 Hippocampus 21 Fructus Toosendans 23.
4. application according to claim 1 is characterized in that the weight portion proportioning of the crude drug of said Chinese medicine composition is:
Semen Cuscutae 150 Fructus Lycii 200 Fructus Schisandrae Chinensis 30 Fructus Cnidiis 50 Fructus Rosae Laevigatae 20
Fructus Rubi 50 Semen Allii Tuberosi 20 Radix Morindae Officinaliss 50 Herba Cistanches 20 Radix Rehmanniae 60
Radix Cyathulae 20 Herba Epimedii 100 Radix Ginsengs 15 Cornu Cervi Pantotrichums 25 Hippocampus 10 Fructus Toosendans 35.
5. according to each described application of claim 1-4, it is characterized in that the active component of said Chinese medicine composition is processed by following steps:
A, take by weighing Chinese crude drug, clean according to the crude drug part by weight;
B, get Fructus Cnidii, Semen Cuscutae, Fructus Schisandrae Chinensis, Herba Epimedii and add 6-10 and doubly measure 60-80% ethanol, reflux, extract, 1-3 time, each 1-3 hour, filter, collecting decoction, decompression recycling ethanol is to there not being the alcohol flavor, and is subsequent use;
Medical material residue after c, Fructus Lycii, Radix Rehmanniae, Fructus Rubi, Fructus Rosae Laevigatae, Semen Allii Tuberosi, Radix Morindae Officinalis, Fructus Toosendan and the alcohol extraction merges; Add water 6-10 and doubly measure decoction 1-3 time; Each 1-3 hour, filter merging filtrate; Mix with step b gained alcohol extract, measuring relative density during 60 ℃ of simmer down tos is the clear paste of 1.25-1.30;
D, Radix Ginseng, Cornu Cervi Pantotrichum, Hippocampus, Herba Cistanches, Radix Cyathulae are ground into fine powder;
Step c gained clear paste and steps d gained fine powder constitute the active component of this Chinese medicine composition jointly.
6. according to each described application of claim 1-4, it is characterized in that said Chinese medicine composition pharmaceutical dosage form is capsule, tablet, powder, oral liquid, pill, tincture, syrup, suppository, gel, spray or injection.
7. application according to claim 6 is characterized in that said capsule is to be processed by following steps:
A, take by weighing Chinese crude drug, clean according to the crude drug part by weight;
B, get Fructus Cnidii, Semen Cuscutae, Fructus Schisandrae Chinensis, Herba Epimedii and add 6-10 and doubly measure 60-80% ethanol, reflux, extract, 1-3 time, each 1-3 hour, filter, collecting decoction, decompression recycling ethanol is to there not being the alcohol flavor;
Medical material residue after c, Fructus Lycii, Radix Rehmanniae, Fructus Rubi, Fructus Rosae Laevigatae, Semen Allii Tuberosi, Radix Morindae Officinalis, Fructus Toosendan and the alcohol extraction merges; Add water 6-10 and doubly measure decoction 1-3 time; Each 1-3 hour, filter merging filtrate; Mix with step b gained alcohol extract, measuring relative density during 60 ℃ of simmer down tos is the clear paste of 1.25-1.30;
D, Radix Ginseng, Cornu Cervi Pantotrichum, Hippocampus, Herba Cistanches, Radix Cyathulae are ground into fine powder;
E, with steps d gained fine powder and step c gained clear paste mixing and stirring, oven dry is pulverized, and incapsulates, and promptly gets.
8. like the described application of claim 1-4; It is characterized in that this Chinese medicine composition improves the application in insomnia and dreamful sleep that climacteric syndrome causes, hectic fever hyperhidrosis, sore waist and aching in the waist and the back, hypomnesis, dizziness and tinnitus, irritated irritability, the abnormal emotion-thought medicine in preparation.
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| CN103386005B (en) * | 2012-05-12 | 2017-08-25 | 石家庄以岭药业股份有限公司 | A kind of application of Chinese medicine composition in the medicine for preparing treatment learning memory disorder |
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| CN112656889A (en) * | 2019-10-16 | 2021-04-16 | 石家庄以岭药业股份有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for protecting vascular endothelial cells |
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| CN113332374A (en) * | 2020-02-18 | 2021-09-03 | 石家庄以岭药业股份有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for inhibiting endometrial hyperplasia |
| CN112220871A (en) * | 2020-11-05 | 2021-01-15 | 尹志宽 | Estrogen receptor activator and preparation method thereof |
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| CN1403145A (en) * | 2002-10-24 | 2003-03-19 | 河北以岭医药研究院有限公司 | Medicine composition for treating impotence and its prepn |
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