CN1403145A - Medicine composition for treating impotence and its prepn - Google Patents
Medicine composition for treating impotence and its prepn Download PDFInfo
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Abstract
The present invention is aimed at strengthening physique and raising sexual function via nourishing Yin, filling life essence and strengthening Yang. The comdposite medicine for treating impotence is prepared with ten kinds of Chinese medicinal materials including dodder seed, wolfberry fruit, schisandra, cnidium fruit, cherokee rose fruit, etc. The pharmacological test shows that the medicine of the present invention can raise the excitement of the penis of emasculated rat to external stimulation, shorten the period for the penis to erect and raise level of testosterone in serum.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method for the treatment of sexual impotence, belong to the Chinese herbal and crude drugs preparations technical field, be particularly useful for treating clinically diseases such as impotence and premature ejaculation, soreness of waist and knee joint, fatigue and asthenia.
Background technology
Theory of Chinese medical science is thought the reproductive function of vital essence decision human body of " kidney ", and hyposexuality appears in congenital natural endowment deficiency or take good care of the day after tomorrow and inappropriate etc. all can cause the loss of kidney essense gas, impotence and premature ejaculation, and dizziness and tinnitus, Mental fatigue is forgetful, soreness of waist and knee joint, fatigue and asthenia.At present, to the treatment of sexual impotence, how to be its well-established law traditionally to control from the kidney opinion, bias toward warming and recuperating the kidney-YANG, " heat " is the basic characteristics of tonifying YANG class drug products, as Colla cornus cervi granule (temperature compensation Liver and kidney, beneficial intensive culture blood), compound recipe XUANJU oral liquid (the kidney warming, tonifying YANG, benefit essence) etc.Sun loses an amount of in the winter time the taking of person and has certain effect, but to spring, the metabolism of human body is progressively active, add that weather is changeable, continue to make human body be difficult to adapt to and bring out various diseases behind the hot thing of absorption, summer, autumn take, then the people knows from experience the pincer attack that is subjected to interior-heat and exterior-heat, the property of medicine is trapped in the body and is difficult to drain, cause Light-headedness, uncomfortable in chest, the lather of heat in the heart, what have also can go out nose bleeding, as takes constantly, also can injure body, and be the hidden danger that stays of other diseases.The present invention selects the heavy seed medicine of eight kinds of property savoury for use, gets its seed procreation Source of life, mends human body procreation Source of life, the dry strong fraud of medea as none, gentle soft and moist, grow and fill out very essence, tonifying both YIN and YANG, both impure YANG invigorating, also not single nourishing YIN, fill out kidney essense but grow, mend the Kidney-Yin invigorating kidney-YANG that comes, positive cloudy helping, biochemical infinite, cloudy De Yangsheng, fountainhead is inexhaustible.
Summary of the invention
The present invention is with the replenishing essence of traditional Chinese medical science YIN nourishing, and temperature is held up Yuanyang, with strong kidney yang, reaches the purpose of building body and sexual function improvement by the kidney invigorating essence.
Technical scheme of the present invention is achieved in that the pharmaceutical composition of this treatment sexual impotence, and its proportion of composing (w/w) comprises Semen Cuscutae 150-350 part, Fructus Lycii 100-200 part, Fructus Schisandrae Sphenantherae 30-60 part, Fructus Cnidii 20-50 part, Fructus Rosae Laevigatae 20-50 part, Semen Allii Tuberosi 20-50 part, Radix Morindae Officinalis 20-50 part, Herba Cistanches 20-50 part, Radix Rehmanniae 30-60 part, Radix Cyathulae 20-50 part.
The pharmaceutical composition of described treatment sexual impotence, its proportion of composing (w/w) comprise 250 parts of Semen Cuscutae, 138 parts of Fructus Lycii, 70 parts of Herba Epimedii, 46 parts of Fructus Schisandrae Sphenantheraes, 35 parts of Fructus Cnidiis, 35 parts of Fructus Rosae Laevigatae, 35 parts of Fructus Rubies, 35 parts of Semen Allii Tuberosi, 35 parts of Radix Morindae Officinaliss, 35 parts of Herba Cistanches, 46 parts of Radix Rehmanniae, 35 parts of Radix Cyathulaes, 25 parts of Radix Ginsengs, 16 parts in Cornu Cervi Pantotrichum, 21 parts of Hippocampus, 23 parts of Fructus Toosendans.
The pharmaceutical composition of described treatment sexual impotence, its form also can comprise the Radix Astragali, Radix Scrophulariae, the Cortex Eucommiae, Solenognathus, Cordyceps, Testis et penis callorhini, Endoconcha Sepiae, Ootheca Mantidis, Semen Euryales, Rhizoma Dioscoreae, Radix Dipsaci, Radix Rehmanniae Preparata, Semen Nelumbinis wherein one or more.
The preparation of drug combination method of above-mentioned treatment sexual impotence comprises:
(1), get 35 parts of Fructus Cnidiis, 250 parts of Semen Cuscutae, 46 parts of Fructus Schisandrae Chinensis, 70 parts of Herba Epimedii, add 8 times of amount 70% ethanol, reflux, extract, 2 times, each 2 hours, filter, collecting decoction, decompression recycling ethanol is not to there being the alcohol flavor, residue is standby;
(2), with the medical material residue after the alcohol extraction and 138 parts of Fructus Lycii, 46 parts of Radix Rehmanniae, 35 parts of Fructus Rubies, 35 parts of Fructus Rosae Laevigatae, 35 parts of Semen Allii Tuberosi, 35 parts of Radix Morindae Officinaliss, 23 parts of merging of Fructus Toosendan, adding 9 times of amounts of water decocts twice, each 2 hours, filter, merging filtrate, mix with step (1) alcohol extract, be evaporated to the clear paste of relative density 1.25-1.30 (60 ℃);
(3), 25 parts of Radix Ginsengs, 16 parts in Cornu Cervi Pantotrichum, 21 parts of Hippocampus, 35 parts of Herba Cistanches, Radix Cyathulae be ground into fine powder for 35 parts, with above-mentioned clear paste mix homogeneously, 65-70 ℃ of oven dry, pulverizes, and sieves, and be promptly encapsulated.
The mixture that make the preparation of drug combination method step (1) of described treatment sexual impotence, (2), (3) can be used for preparing clinically the base stock of tablet, electuary, powder.
Pharmacological testing studies show that through traditional Chinese medical science pharmacology teaching and research room of the college of traditional Chinese medicine of Hebei Medical University, and capsule of the present invention (trade name is eight sub-kings or eight sub-capsule for tonifying kidney) can improve the irritability of castrated rats penis to outside stimulus, shortens erection incubation period; Improve serum testosterone level.Observation is to the influence of rat mating ability, and the result shows can improve male Mus mating ability.Observation is to the influence of yang deficiency mouse anti-reflecting fatigue ability, and the result shows can prolong the swimming time of yang deficiency mice; Observation is to the influence of mice low temperature survival ability, and the result shows can improve the mice low temperature tolerance ability.
Acute toxicity test in mice shows that mouse stomach administration maximum is 23.2g/kg/ day, 682.4 times of the clinical consumption that is equivalent to be grown up, animal Non Apparent Abnormality and death.Long term toxicity test shows: capsule of the present invention does not all have obvious influence to biochemical indicator such as the general situation of rat, body weight, hemogram and main organs coefficient, illustrates that the present invention does not have the overt toxicity reaction.See Appendix.
The specific embodiment
Face illustrates the specific embodiment of the present invention in conjunction with the example of drug regimen of the present invention.
Embodiment 1: Semen Cuscutae 250g Fructus Lycii 138g Herba Epimedii 70g Fructus Schisandrae Sphenantherae 46g Fructus Cnidii 35g Fructus Rosae Laevigatae 35g Fructus Rubi 35g Semen Allii Tuberosi 35g Radix Morindae Officinalis 35g Herba Cistanches 35g Radix Rehmanniae 46g Radix Cyathulae 35g Radix Ginseng 25g Cornu Cervi Pantotrichum 16g Hippocampus 21g Fructus Toosendan 23g preparation method:
(1), get 35 parts of Fructus Cnidiis, 250 parts of Semen Cuscutae, 46 parts of Fructus Schisandrae Chinensis, 70 parts of Herba Epimedii, add 8 times of amount 70% ethanol, reflux, extract, 2 times, each 2 hours, filter, collecting decoction, decompression recycling ethanol is not to there being the alcohol flavor, residue is standby;
(2), with the medical material residue after the alcohol extraction and 138 parts of Fructus Lycii, 46 parts of Radix Rehmanniae, 35 parts of Fructus Rubies, 35 parts of Fructus Rosae Laevigatae, 35 parts of Semen Allii Tuberosi, 35 parts of Radix Morindae Officinaliss, 23 parts of merging of Fructus Toosendan, adding 9 times of amounts of water decocts twice, each 2 hours, filter, merging filtrate, mix with step (1) alcohol extract, be evaporated to the clear paste of relative density 1.25-1.30 (60 ℃);
(3), 25 parts of Radix Ginsengs, 16 parts in Cornu Cervi Pantotrichum, 21 parts of Hippocampus, 35 parts of Herba Cistanches, Radix Cyathulae be ground into fine powder for 35 parts, with above-mentioned clear paste mix homogeneously, 65-70 ℃ of oven dry, pulverizes, and sieves, and be promptly encapsulated.
The mixture that make the preparation of drug combination method step (1) of above-mentioned treatment sexual impotence, (2), (3) can be used for preparing clinically the base stock of tablet, electuary, powder etc.
Embodiment 2, Semen Cuscutae 100g Fructus Lycii 65g Fructus Schisandrae Sphenantherae 25g Fructus Cnidii 15g Fructus Rosae Laevigatae 35g Semen Allii Tuberosi 35g Radix Morindae Officinalis 35g Herba Cistanches 35g Radix Rehmanniae 46g Radix Cyathulae 35g
Embodiment 3, Semen Cuscutae 350g Fructus Lycii 200g Fructus Schisandrae Sphenantherae 46g Fructus Cnidii 35g Fructus Rosae Laevigatae 50g Semen Allii Tuberosi 50g Radix Morindae Officinalis 35g Herba Cistanches 35g Radix Rehmanniae 46g Radix Cyathulae 35g
Embodiment 4, Semen Cuscutae 250g Fructus Lycii 138g Herba Epimedii 70g Fructus Schisandrae Sphenantherae 46g Fructus Cnidii 35g Fructus Rubi 35g Semen Allii Tuberosi 35g Cornu Cervi Pantotrichum 16g Herba Cistanches 35g Radix Rehmanniae 46g Radix Cyathulae 35g Radix Ginseng 25g
Embodiment 5, Semen Cuscutae 250g Fructus Lycii 138g Fructus Psoraleae 70g Fructus Schisandrae Sphenantherae 46g Fructus Cnidii 35g Fructus Corni 70g Fructus Rubi 35g Semen Allii Tuberosi 35g Radix Morindae Officinalis 35g Herba Cistanches 35g Radix Rehmanniae Preparata 46g Radix Cyathulae 35g Radix Astragali 25g Cornu Cervi Pantotrichum 16g Solenognathus 21g Fructus Toosendan 23g Radix Astragali 25g Cornu Cervi Pantotrichum 16g Solenognathus 21g Fructus Toosendan 23g
Embodiment 6, Semen Cuscutae 250g Fructus Lycii 138g Cortex Eucommiae 70g Fructus Schisandrae Sphenantherae 46g Fructus Cnidii 35g Semen Allii Tuberosi 35g Rhizoma Atractylodis Macrocephalae 25g Cornu Cervi Pantotrichum 16g Cordyceps 35g Herba Cistanches 35g Radix Scrophulariae 46g Radix Cyathulae 35g Testis et penis callorhini 21g Fructus Toosendan 23g
Embodiment 7, Semen Cuscutae 250g Semen Astragali Complanati 138g Herba Epimedii 70g Fructus Schisandrae Sphenantherae 46g Fructus Cnidii 35g Ootheca Mantidis 35g Semen Euryales 35g Semen Allii Tuberosi 35g Radix Morindae Officinalis 35g Herba Cistanches 35g Radix Rehmanniae 46g Radix Cyathulae 35g Radix Ginseng 25g Cornu Cervi Pantotrichum 16g Hippocampus 21g Fructus Toosendan 23g
Embodiment 8, Semen Cuscutae 250g Fructus Ligustri Lucidi 138g Radix Dipsaci 70g Fructus Schisandrae Sphenantherae 46g Fructus Cnidii 35g Endoconcha Sepiae 35g Rhizoma Dioscoreae 50g Cornu Cervi Pantotrichum 16g Radix Morindae Officinalis 35g Herba Cistanches 35g Radix Scrophulariae 46g Radix Cyathulae 35g Fructus Toosendan 23g
Embodiment 9, Semen Cuscutae 250g Radix Rehmanniae Preparata 138g Herba Epimedii 70g Fructus Schisandrae Sphenantherae 46g Fructus Cnidii 35g Fructus Rosae Laevigatae 35g Semen Nelumbinis 35g Semen Allii Tuberosi 35g Radix Morindae Officinalis 35g Herba Cistanches 35g Radix Rehmanniae 46g Radix Cyathulae 35g Radix Astragali 50g Cornu Cervi Pantotrichum 36g Hippocampus 21g Radix Bupleuri 35g
The dried cream mixture that the preparation method of the foregoing description is made can be used for preparing clinically the base stock of oral formulations such as tablet, electuary, powder, oral liquid.The preparation method of embodiment 2-9 and embodiment 1 are basic identical.
Claims (4)
1, a kind of pharmaceutical composition for the treatment of sexual impotence, its proportion of composing (w/w) comprise Semen Cuscutae 150-350 part, Fructus Lycii 100-200 part, Fructus Schisandrae Sphenantherae 30-60 part, Fructus Cnidii 20-50 part, Fructus Rosae Laevigatae 20-50 part, Semen Allii Tuberosi 20-50 part, Radix Morindae Officinalis 20-50 part, Herba Cistanches 20-50 part, Radix Rehmanniae 30-60 part, Radix Cyathulae 20-50 part.
2, the pharmaceutical composition of treatment sexual impotence according to claim 1, its proportion of composing (w/w) comprise 250 parts of Semen Cuscutae, 138 parts of Fructus Lycii, 70 parts of Herba Epimedii, 46 parts of Fructus Schisandrae Sphenantheraes, 35 parts of Fructus Cnidiis, 35 parts of Fructus Rosae Laevigatae, 35 parts of Fructus Rubies, 35 parts of Semen Allii Tuberosi, 35 parts of Radix Morindae Officinaliss, 35 parts of Herba Cistanches, 46 parts of Radix Rehmanniae, 35 parts of Radix Cyathulaes, 25 parts of Radix Ginsengs, 16 parts in Cornu Cervi Pantotrichum, 21 parts of Hippocampus, 23 parts of Fructus Toosendans.
3, the pharmaceutical composition of treatment sexual impotence according to claim 1, its form also can comprise the Radix Astragali, Radix Scrophulariae, the Cortex Eucommiae, Solenognathus, Cordyceps, Testis et penis callorhini, Endoconcha Sepiae, Ootheca Mantidis, Semen Euryales, Rhizoma Dioscoreae, Radix Dipsaci, Radix Rehmanniae Preparata, Semen Nelumbinis wherein one or more.
4, the preparation of drug combination method of above-mentioned treatment sexual impotence comprises:
(1), get 35 parts of Fructus Cnidiis, 250 parts of Semen Cuscutae, 46 parts of Fructus Schisandrae Chinensis, 70 parts of Herba Epimedii, add 8 times of amount 70% ethanol, reflux, extract, 2 times, each 2 hours, filter, collecting decoction, decompression recycling ethanol is not to there being the alcohol flavor, residue is standby;
(2), with the medical material residue after the alcohol extraction and 138 parts of Fructus Lycii, 46 parts of Radix Rehmanniae, 35 parts of Fructus Rubies, 35 parts of Fructus Rosae Laevigatae, 35 parts of Semen Allii Tuberosi, 35 parts of Radix Morindae Officinaliss, 23 parts of merging of Fructus Toosendan, adding 9 times of amounts of water decocts twice, each 2 hours, filter, merging filtrate, mix with step (1) alcohol extract, be evaporated to the clear paste of relative density 1.25-1.30 (60 ℃);
(3), 25 parts of Radix Ginsengs, 16 parts in Cornu Cervi Pantotrichum, 21 parts of Hippocampus, 35 parts of Herba Cistanches, Radix Cyathulae be ground into fine powder for 35 parts, with above-mentioned clear paste mix homogeneously, 65-70 ℃ of oven dry, pulverizes, and sieves, and be promptly encapsulated.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB02146569XA CN1186070C (en) | 2002-10-24 | 2002-10-24 | Medicine composition for treating impotence and its prepn |
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| CNB02146569XA CN1186070C (en) | 2002-10-24 | 2002-10-24 | Medicine composition for treating impotence and its prepn |
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| CN1186070C CN1186070C (en) | 2005-01-26 |
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| CN107233481A (en) * | 2017-06-07 | 2017-10-10 | 中国热带农业科学院热带作物品种资源研究所 | A kind of Chinese medicine composition invigorated the kidney and stopped nocturnal emission, medicinal liquor and its preparation method and application |
| CN108066575A (en) * | 2018-03-05 | 2018-05-25 | 鹤壁市岐黄中医学研究院有限公司 | A kind of Chinese medicine composition for being used to treat impotence and premature ejaculation |
| CN111920902A (en) * | 2020-07-21 | 2020-11-13 | 朱贤刚 | Traditional Chinese medicine composition for improving immunity and preparation method thereof |
| CN112245550A (en) * | 2020-10-22 | 2021-01-22 | 王建军 | A Chinese medicinal composition with effect in regulating emotion, and its preparation method |
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| CN1186070C (en) | 2005-01-26 |
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