CN109820979A - A kind of pharmaceutical composition and preparation method thereof for treating kidney-yang deficiency - Google Patents
A kind of pharmaceutical composition and preparation method thereof for treating kidney-yang deficiency Download PDFInfo
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Abstract
A kind of pharmaceutical composition and preparation method thereof for treating kidney-yang deficiency, is related to a kind of pharmaceutical composition, and in particular to a kind of pharmaceutical composition for treating kidney deficiency.The raw material of pharmaceutical composition of the present invention include: pilose antler, gekko, Herba Epimedii, leek seed, Fructus Corni, Rehmannia glutinosa, cynomorium songaricum, cortex cinnamomi, fructus lycii, prepared fleece flower root, Radix Astragali, radix bupleuri, Herba Cistanches, fructus alpiniae oxyphyllae, Schisandra chinensis, thizoma curculiginis, silkworm moth, ginseng and safflower;It is extracted by the effective component to raw material, to obtain pharmaceutical composition.The present invention is applied to contain the treatment of the deficiency of yang.
Description
Technical field
The present invention relates to a kind of pharmaceutical compositions, and in particular to a kind of pharmaceutical composition for treating kidney deficiency.
Background technique
Kidney-yang deficiency, the also known as insufficiency of the kidney yang, decline of kidney-YANG.It is the warm dereliction of duty due to decline of kidney-YANG, gasification loses what power was showed
A kind of cold of insufficiency type syndrome, with aversion to cold and cold limbs, waist is the following are very, pale complexion or dark, spiritlessness and weakness, clear abundant urine, frequent urination at night, pale tongue
Whitish tongue, weak pulse etc. are the syndrome of common disease.Mostly by innate deficiency of YANG in the body, or old deficiency of the kidney or prolonged illness be impairment of the kidney and excess of sexual intercourse,indulgence in sexual activities etc. because
Caused by element.
The syndrome of kidney-yang deficiency is mainly shown as " soreness and weakness of waist and knees and pain;Impotence in male premature ejaculation, woman's fertility;Chilly limb
Cold, edema, for waist the following are very, lower limb are very;Pale complexion, vertigo;Darkish complexion is without pool, frequent urination, clear long, enuresis nocturna
It is more;The fat whitish tongue of pale tongue, forceless deep pulse and it is slow.".
The drug of most for the treatment of kidney deficiency is all generally not carry out area for kidney-yang deficiency and kidney-yin deficiency different situations at present
Point, i.e., it is all generally the drug for declaring treatment kidney deficiency.And actual kidney deficiency situation is divided into kidney-yang deficiency and kidney-yin deficiency, two kinds of kidneys
Empty Crack cause and clinical symptoms be all it is different, since in theory of traditional Chinese medical science, drug is all mutually auxiliary restriction or checking relation in five elements, so controlling
The drug for the treatment of also can different from.Just because of current treatment kidney deficiency drug be not directed to actual conditions difference and
It distinguishes, so its drug effect naturally will not be fairly obvious.
At present on the market there are also distinguishing the drug treated for different kidney deficiency type kidney deficiency, such as application No. is
The patent of CN200810224504.6 is exactly a kind of drug specifically for kidney-yang deficiency.Kidney deficiency is mentioned, the intrinsic impression of people is
The problem of kidney deficiency is puzzlement male, actually women the problem of there is also kidney-yang deficiencies.Although application No. is
The patent of CN200810224504.6 achieves good effect, has good effect for male, but does not examine
Consider the individual factors of actual patient's male and female, is directed to working well for male so as to cause its medication ingredient, still
It is directed to for women, drug effect needs to be further increased.
Summary of the invention
It is an object of that present invention to provide a kind of pharmaceutical compositions for being directed to the general treatment kidney-yang deficiency of male and female.
It is a kind of for treating the pharmaceutical composition of kidney-yang deficiency, be prepared by following methods:
Raw material include:
Pilose antler 300-700 parts by weight, gekko 500-1300 parts by weight, Herba Epimedii 500-1300 parts by weight, leek seed 800-
1200 parts by weight, Fructus Corni 2500-3000 parts by weight, Rehmannia glutinosa 900-1200 parts by weight, cynomorium songaricum 300-700 parts by weight, cortex cinnamomi
2500-3000 parts by weight, 1300-1800 parts of fructus lycii, prepared fleece flower root 500-1300 parts by weight, Radix Astragali 900-1200 parts by weight,
Radix bupleuri 2000-3000 parts by weight, Herba Cistanches 500-1300 parts by weight, fructus alpiniae oxyphyllae 800-1200 parts by weight, Schisandra chinensis 500-1300
Parts by weight, thizoma curculiginis 1500-2500 parts by weight, silkworm moth 1000-1500 parts by weight, ginseng 2500-3200 parts by weight;
Raw material further include: safflower 150-200 parts by weight;
Oroxylum indicum, dried orange peel, aspongopus are not contained in raw material;
Pharmaceutical composition is made in raw material as follows:
A, to 400~600 parts by weight silkworm moths, 20~90% ethanol percolation, solution is obtained;
To 200~300 parts by weight silkworm moths, 10~80% alcohol refluxs, solution is obtained;
To 400~600 parts by weight silkworm moths, 65% alcohol steep, solution is obtained;
Above-mentioned three kinds of solution is recycled, is mixed spare;
B, by the fructus lycii of above-mentioned parts by weight, Herba Cistanches, Herba Epimedii, Rehmannia glutinosa, Schisandra chinensis, Radix Astragali, ginseng, radix bupleuri, fragrant-flowered garlic
Vegetable seeds, ten herbal medicine of fructus alpiniae oxyphyllae add water to cook, and so that alcohol content is reached 20~80% with ethanol precipitation after taking decoction liquor to be concentrated, filtering
After take supernatant spare;
C, the safflower of above-mentioned parts by weight is added into 70~80% alcohol dipping 2-3 days, then be added pilose antler, gekko, Fructus Corni,
Thizoma curculiginis, cynomorium songaricum, prepared fleece flower root, cortex cinnamomi, ethyl alcohol sealing dipping 13~15 days, filtering takes concoction spare;
D, the decoction stoste that first three step obtains is recycled into ethyl alcohol after mixing, is concentrated, 40~50 DEG C of drying 20~
50 minutes, medicinal powder is crushed to obtain, obtains the medicinal powder of pharmaceutical composition.
Wherein, the relationship of the parts by weight in pharmaceutical composition and preparation method thereof and parts by volume is the relationship of g/ml.
Further, the composition of raw material is as follows:
650 parts by weight of pilose antler, 820 parts by weight of gekko, 800 parts by weight of Herba Epimedii, 1000 parts by weight of leek seed, Fructus Corni
3000 parts by weight, 920 parts by weight of Rehmannia glutinosa, 300 parts by weight of cynomorium songaricum, 2500 parts by weight of cortex cinnamomi, 1300 parts of fructus lycii, prepared fleece flower root
950 parts by weight, 1000 parts by weight of Radix Astragali, radix bupleuri 2000- parts by weight, 750 parts by weight of Herba Cistanches, 1200 parts by weight of fructus alpiniae oxyphyllae, five
550 parts by weight of taste, 1500 parts by weight of thizoma curculiginis, 1500 parts by weight of silkworm moth, 2500 parts by weight of ginseng, 200 parts by weight of safflower.
Further, in the step B, alcohol content is made to reach 80%, after filtering with ethanol precipitation after taking decoction liquor to be concentrated
Take supernatant spare.
Further, in the step C, the safflower of above-mentioned parts by weight added into 70~80% alcohol dipping 2-3 days, then
Pilose antler, gekko, Fructus Corni, thizoma curculiginis, cynomorium songaricum, prepared fleece flower root, cortex cinnamomi, ethyl alcohol is added and seals dipping 13~15 days, first 6~8 days, often
Its stirring 1~3 time latter 6~8 days, squeezes the dregs of a decoction after stirring 1~2 time, 13~15 days every other day, filters, take concoction spare.
Further, in the step D, the decoction stoste that first three step obtains is recycled into ethyl alcohol after mixing, it is dense
Contracting, 40 DEG C dry 50 minutes, crush to obtain medicinal powder, obtain the medicinal powder of pharmaceutical composition.
It is a kind of for treating the pharmaceutical composition pill of kidney-yang deficiency, take 0.3~0.4 weight of medicinal powder of aforementioned pharmaceutical compositions
Part, 5~15 parts by volume of distilled water, 3~5 parts by volume of royal jelly mix, and then pharmaceutical composition pill is made.
The invention has the following advantages:
The medication principle of combination tradition kidney-yang deficiency of the invention, it is former in conjunction with certain neuroendocrine-immune system medication
Reason the characteristics of in combination with male and female, the drug of traditional treatment kidney-yang deficiency is improved, eliminates and is poorly suitable for
The drug of women, and some other raw material are pharmacologically being added to, so that the present invention can be applied not only to male, Er Qiezhen
Also there is good effect for female patient.
Specific embodiment
Specific embodiment 1:
It is a kind of for treating the pharmaceutical composition of kidney-yang deficiency, be prepared by following methods:
Raw material include:
Pilose antler 300-700 parts by weight, gekko 500-1300 parts by weight, Herba Epimedii 500-1300 parts by weight, leek seed 800-
1200 parts by weight, Fructus Corni 2500-3000 parts by weight, Rehmannia glutinosa 900-1200 parts by weight, cynomorium songaricum 300-700 parts by weight, cortex cinnamomi
2500-3000 parts by weight, 1300-1800 parts of fructus lycii, prepared fleece flower root 500-1300 parts by weight, Radix Astragali 900-1200 parts by weight,
Radix bupleuri 2000-3000 parts by weight, Herba Cistanches 500-1300 parts by weight, fructus alpiniae oxyphyllae 800-1200 parts by weight, Schisandra chinensis 500-1300
Parts by weight, thizoma curculiginis 1500-2500 parts by weight, silkworm moth 1000-1500 parts by weight, ginseng 2500-3200 parts by weight, safflower 150-
200 parts by weight;
Oroxylum indicum, dried orange peel, aspongopus are not contained in raw material;
Pharmaceutical composition is made in raw material as follows:
A, to 400~600 parts by weight silkworm moths, 20~90% ethanol percolation, solution is obtained;
To 200~300 parts by weight silkworm moths, 10~80% alcohol refluxs, solution is obtained;
To 400~600 parts by weight silkworm moths, 65% alcohol steep, solution is obtained;
Above-mentioned three kinds of solution is recycled, is mixed spare;
B, by the fructus lycii of above-mentioned parts by weight, Herba Cistanches, Herba Epimedii, Rehmannia glutinosa, Schisandra chinensis, Radix Astragali, ginseng, radix bupleuri, fragrant-flowered garlic
Vegetable seeds, ten herbal medicine of fructus alpiniae oxyphyllae add water to cook, and so that alcohol content is reached 20~80% with ethanol precipitation after taking decoction liquor to be concentrated, filtering
After take supernatant spare;
C, the safflower of above-mentioned parts by weight is added into 70~80% alcohol dipping 2-3 days, then be added pilose antler, gekko, Fructus Corni,
Thizoma curculiginis, cynomorium songaricum, prepared fleece flower root, cortex cinnamomi, ethyl alcohol sealing dipping 13~15 days, filtering takes concoction spare;
D, the decoction stoste that first three step obtains is recycled into ethyl alcohol after mixing, is concentrated, 40~50 DEG C of drying 20~
50 minutes, medicinal powder is crushed to obtain, obtains the medicinal powder of pharmaceutical composition.
Wherein, the relationship of the parts by weight in pharmaceutical composition and preparation method thereof and parts by volume is the relationship of g/ml.
In fact, finding by years of researches, kidney-yang deficiency is not only the function problem of body internal organs organ, also with mind
There is certain relationship through endocrine-immune system (NEIS).The pharmaceutical composition of previous treatment kidney-yang deficiency often only considers from advantageous
In the drug of the recovery of kidney and health care, to obtain certain curative effect, while also just because of this medication theory and
Pharmacology principle, although just making pervious drug that can distinguish medication treatment for kidney-yin deficiency and kidney-yang deficiency.But it is previous
Idea be that drug is used for the treatment of male's kidney deficiency mostly, but due to the kidney-yang deficiency not only machine with kidney and other organs
Can be related, but also have certain relationship with neuroendocrine-immune system, simultaneously because the physiology of male and female is distinguished, so that
The internal organs such as male's and women's urinary system and endocrine-immune system have certain difference, so that existing treatment
The drug of kidney-yang deficiency is preferable to the curative effect of male, but is directed to for women, effect be not it is very ideal, only help
Help female patient that there is certain curative effect from the conditioning and health care of kidney.
Kidney-yang deficiency drug and clinically relevant scientific research by many years, the medication principle of combination tradition kidney-yang deficiency of the invention,
In conjunction with certain neuroendocrine-immune system medication principle, the characteristics of in combination with male and female, by traditional treatment kidney
The drug of the deficiency of yang is improved, and eliminates the drug for being poorly suitable for women, and be pharmacologically added to some other raw material,
So that the present invention can be applied not only to male, and it is directed to female patient also there is good effect, wherein safflower is passing
Activating microcirculation and removing stasis medicinal is used on overall view point, but why the present invention introduces safflower, is risen by the effect of its activating microcirculation and removing stasis medicinal
To promoting neuroendocrine-immune system the effect adjusted, while being aided with the other drugs such as Radix Astragali, gekko, Herba Epimedii and carrying out pair
Neuroendocrine-immune system promotes to adjust, while Radix Astragali also has the effects that anti-inflammatory benefit water, so that all drugs are integrally to male
The kidney-yang deficiency of property and women are treated.
Specific embodiment 2:
The composition of raw material of present embodiment is as follows:
650 parts by weight of pilose antler, 820 parts by weight of gekko, 800 parts by weight of Herba Epimedii, 1000 parts by weight of leek seed, Fructus Corni
3000 parts by weight, 920 parts by weight of Rehmannia glutinosa, 300 parts by weight of cynomorium songaricum, 2500 parts by weight of cortex cinnamomi, 1300 parts of fructus lycii, prepared fleece flower root
950 parts by weight, 1000 parts by weight of Radix Astragali, radix bupleuri 2000- parts by weight, 750 parts by weight of Herba Cistanches, 1200 parts by weight of fructus alpiniae oxyphyllae, five
550 parts by weight of taste, 1500 parts by weight of thizoma curculiginis, 1500 parts by weight of silkworm moth, 2500 parts by weight of ginseng, 200 parts by weight of safflower.
Other compositions and step are same as the specific embodiment one.
Present embodiment be to specific embodiment one carry out it is preferred, in the raw material of specific embodiment one, although
Good drug effect can be obtained, but due to usually being matched in a certain range to raw material in important composition,
Some may be more in appropriate range, some are then few, and in this case, the effective component of some drugs is actually
Have reached its play a role in the range of, extra drug is not obviously improved drug effect, so causing raw material
Waste, present embodiment after the optimization of raw material, are guaranteeing there is good effect base in effective weight ratio
On plinth, a big chunk raw material can be saved.And the proportion of raw material of present embodiment also has good effect, i.e. medicine
The composition proportion of object is more reasonable.
Specific embodiment 3:
In step B described in present embodiment, alcohol content is set to reach 80%, after filtering with ethanol precipitation after taking decoction liquor to be concentrated
Take supernatant spare.
Other compositions and step are the same as one or two specific embodiments.
When so that alcohol content is reached 80% with ethanol precipitation after taking decoction liquor to be concentrated, the maximum of effective ingredient ensure that
Degree is collected, to further avoid the waste of raw material.
Specific embodiment 4:
In step C described in present embodiment, the safflower of above-mentioned parts by weight added into 70~80% alcohol dipping 2-3 days, then
Pilose antler, gekko, Fructus Corni, thizoma curculiginis, cynomorium songaricum, prepared fleece flower root, cortex cinnamomi, ethyl alcohol is added and seals dipping 13~15 days, first 6~8 days, often
Its stirring 1~3 time latter 6~8 days, squeezes the dregs of a decoction after stirring 1~2 time, 13~15 days every other day, filters, take concoction spare.
Other compositions and step are identical as one of specific embodiment one to three.
Present embodiment is also for the utmostly collection for guaranteeing effective ingredient, to further avoid former material
The waste of material.
Specific embodiment 5:
In step D described in present embodiment, the decoction stoste that first three step obtains is recycled into ethyl alcohol after mixing, it is dense
Contracting, 40 DEG C dry 50 minutes, crush to obtain medicinal powder, sieving weighing;Obtain the medicinal powder of pharmaceutical composition.
Other compositions and step are identical as one of specific embodiment one to four.
Present embodiment carries out the drying of relatively long time in the case where relative low temperature, exactly opposite in order to guarantee
The effective component that there is drug in the environment of low temperature is not destroyed, also for guarantee effective ingredient utmostly collection,
To reduce the use of raw material and guarantee drug effect.
Specific embodiment 6:
It is a kind of for treating the pharmaceutical composition pill of kidney-yang deficiency, take drug described in one of specific embodiment one to five
0.3~0.4 parts by weight of medicinal powder, 5~15 parts by volume of distilled water, 3~5 parts by volume of royal jelly of composition mix, and then drug is made
Composition pill.
Embodiment
Curative effect is verified by the symptomatic condition to clinical trial subjects:
In tested patient, male 50, women 50.
As long as the Symptoms of all patients are the Symptoms of " soreness of waist and knee joint, aversion to cold and cold limbs etc. " kidney-yang deficiency.
By taking the corresponding pill of raw material of the restriction of specific embodiment two, three balls on the one, clothes are bfore meals.
In 100 patients, symptom disappears 58, and wherein male is 31 people, and women is 27 people;Symptom be eased 29
People, wherein male is 10 people, and women is 19 people;13 people that symptom does not improve, wherein male is 9 people, and women is 4 people.
The present invention, which is directed to male and female patient, all has good therapeutic effect.
Claims (6)
1. it is a kind of for treating the pharmaceutical composition of kidney-yang deficiency, it is prepared by following methods:
Raw material include: pilose antler 300-700 parts by weight, gekko 500-1300 parts by weight, Herba Epimedii 500-1300 parts by weight, leek
Seed 800-1200 parts by weight, Fructus Corni 2500-3000 parts by weight, Rehmannia glutinosa 900-1200 parts by weight, cynomorium songaricum 300-700 weight
Part, cortex cinnamomi 2500-3000 parts by weight, 1300-1800 parts of fructus lycii, prepared fleece flower root 500-1300 parts by weight, Radix Astragali 900-1200
Parts by weight, radix bupleuri 2000-3000 parts by weight, Herba Cistanches 500-1300 parts by weight, fructus alpiniae oxyphyllae 800-1200 parts by weight, Schisandra chinensis
500-1300 parts by weight, thizoma curculiginis 1500-2500 parts by weight, silkworm moth 1000-1500 parts by weight, ginseng 2500-3200 parts by weight;
It is characterized in that, the raw material further include: safflower 150-200 parts by weight;And without containing Oroxylum indicum, old in raw material
Skin, aspongopus;
Pharmaceutical composition is made in raw material as follows:
A, to 400~600 parts by weight silkworm moths, 20~90% ethanol percolation, solution is obtained;
To 200~300 parts by weight silkworm moths, 10~80% alcohol refluxs, solution is obtained;
To 400~600 parts by weight silkworm moths, 65% alcohol steep, solution is obtained;
Above-mentioned three kinds of solution is recycled, is mixed spare;
B, by the fructus lycii of above-mentioned parts by weight, Herba Cistanches, Herba Epimedii, Rehmannia glutinosa, Schisandra chinensis, Radix Astragali, ginseng, radix bupleuri, semen allii tuberosi,
Ten herbal medicine of fructus alpiniae oxyphyllae adds water to cook, and so that alcohol content is reached 20~80% with ethanol precipitation after taking decoction liquor to be concentrated, takes after filtering
Supernatant is spare;
C, the safflower of above-mentioned parts by weight is added into 70~80% alcohol dipping 2-3 days, pilose antler, gekko, Fructus Corni, celestial being is then added
Thatch, cynomorium songaricum, prepared fleece flower root, cortex cinnamomi, ethyl alcohol sealing dipping 13~15 days, filtering takes concoction spare;
D, the decoction stoste that first three step obtains is recycled into ethyl alcohol after mixing, is concentrated, 40~50 DEG C dry 20~50 points
Clock crushes to obtain medicinal powder, to the medicinal powder of pharmaceutical composition.
2. according to claim 1 a kind of for treating the pharmaceutical composition of kidney-yang deficiency, which is characterized in that the raw material
Ingredient is as follows:
650 parts by weight of pilose antler, 820 parts by weight of gekko, 800 parts by weight of Herba Epimedii, 1000 parts by weight of leek seed, 3000 weight of Fructus Corni
Amount part, 920 parts by weight of Rehmannia glutinosa, 300 parts by weight of cynomorium songaricum, 2500 parts by weight of cortex cinnamomi, 1300 parts of fructus lycii, 950 weight of prepared fleece flower root
Measure part, 1000 parts by weight of Radix Astragali, radix bupleuri 2000- parts by weight, 750 parts by weight of Herba Cistanches, 1200 parts by weight of fructus alpiniae oxyphyllae, Schisandra chinensis
550 parts by weight, 1500 parts by weight of thizoma curculiginis, 1500 parts by weight of silkworm moth, 2500 parts by weight of ginseng, 200 parts by weight of safflower.
3. according to claim 1 or 2 a kind of for treating the pharmaceutical composition of kidney-yang deficiency, which is characterized in that the step
In rapid B, so that alcohol content is reached 80% with ethanol precipitation after taking decoction liquor to be concentrated, take supernatant spare after filtering.
4. according to claim 1 or 2 a kind of for treating the pharmaceutical composition of kidney-yang deficiency, which is characterized in that the step
In rapid C, the safflower of above-mentioned parts by weight added into 70~80% alcohol dipping 2-3 days, then addition pilose antler, gekko, Fructus Corni, celestial being
Thatch, cynomorium songaricum, prepared fleece flower root, cortex cinnamomi, ethyl alcohol sealing dipping 13~15 days, first 6~8 days, stirring 1~3 time daily, latter 6~8 days,
The dregs of a decoction are squeezed after stirring 1~2 time, 13~15 days every other day, filters, takes concoction spare.
5. according to claim 1 or 2 a kind of for treating the pharmaceutical composition of kidney-yang deficiency, which is characterized in that the step
In rapid D, the decoction stoste that first three step obtains is recycled into ethyl alcohol after mixing, is concentrated, 40 DEG C dry 50 minutes, crush
Medicinal powder obtains the medicinal powder of pharmaceutical composition.
6. a kind of for treating the pharmaceutical composition pill of kidney-yang deficiency, which is characterized in that manufacturing process is as follows:
Take 0.3~0.4 parts by weight of medicinal powder, 5~15 parts by volume of distilled water, bee of one of claim 1 to 5 described pharmaceutical composition
Newborn 3~5 parts by volume, mix, and then pharmaceutical composition pill is made.
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Cited By (1)
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CN112972562A (en) * | 2019-12-16 | 2021-06-18 | 上海中医药大学附属龙华医院 | Traditional Chinese medicine composition for treating erectile dysfunction of middle-aged and elderly men and application thereof |
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CN101721646A (en) * | 2008-10-17 | 2010-06-09 | 侯凤祥 | Medicine composition for treating deficiency of kidney-yang and preparation method thereof |
CN104771563A (en) * | 2015-04-29 | 2015-07-15 | 岳阳新华达制药有限公司 | Kidney tonifying Chinese herbal medicine compound preparation and preparation method thereof |
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Cited By (2)
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CN112972562A (en) * | 2019-12-16 | 2021-06-18 | 上海中医药大学附属龙华医院 | Traditional Chinese medicine composition for treating erectile dysfunction of middle-aged and elderly men and application thereof |
CN112972562B (en) * | 2019-12-16 | 2022-02-11 | 上海中医药大学附属龙华医院 | Traditional Chinese medicine composition for treating erectile dysfunction of middle-aged and elderly men and application thereof |
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