CN104771563A - Kidney tonifying Chinese herbal medicine compound preparation and preparation method thereof - Google Patents

Kidney tonifying Chinese herbal medicine compound preparation and preparation method thereof Download PDF

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CN104771563A
CN104771563A CN201510209588.6A CN201510209588A CN104771563A CN 104771563 A CN104771563 A CN 104771563A CN 201510209588 A CN201510209588 A CN 201510209588A CN 104771563 A CN104771563 A CN 104771563A
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radix
parts
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herba
kidney
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CN104771563B (en
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郭凌云
随裕敏
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YUEYANG XINHUADA PHARMACEUTICAL CO Ltd
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YUEYANG XINHUADA PHARMACEUTICAL CO Ltd
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Abstract

The invention relates to a kidney tonifying Chinese herbal medicine compound preparation. The kidney tonifying Chinese herbal medicine compound preparation is mainly composed of, by weight, 1.5-6 parts of ginseng, 1-4 parts of codonopsis pilosula, 3.5-15 parts of astragalus membranaceus, 0.2-1 part of cornus cervi pantotrichum, 1-4 parts of cinnamon, 3-12 parts of herba epimedii, 1-4 parts of cynomorium songaricum, 1-5 parts of rhizome curculiginis, 1-5 parts of radix aconite carmichaeli, 5-20 parts of Chinese wolfberry fruits, 1.5-6 parts of morinda officinalis, 1-4 parts of herba cistanche, 1-4 parts of gecko, 1-5 parts of semen allii tuberosi, 2-8 parts of angelica sinensis, 1-5 parts of radix paeoniae alba, 3-12 parts of prepared rehmannia roots, 1-4 parts of Chinese magnoliavine fruits, 1-4 parts of dogwood and 2-8 parts of salt eucommia ulmoides. The pharmaceutical preparation of the kidney tonifying Chinese herbal medicine compound preparation is added for preparing oral solutions, tablets, capsules or granules.

Description

A kind of compound Chinese medicinal preparation of the kidney invigorating and preparation method
Technical field
The present invention relates to a kind of is pharmaceutical preparatioies such as main the active component oral liquid, tablet, capsule and the granule that are prepared from and preparation method thereof with several kinds of Chinese medicinal materials.Particularly relate to Radix Ginseng, Radix Codonopsis, the Radix Astragali, Cornu Cervi Pantotrichum, Cortex Cinnamomi, Herba Epimedii, Herba Cynomorii, Rhizoma Curculiginis, Radix Aconiti Lateralis Preparata, Fructus Lycii, Radix Morindae Officinalis, Herba Cistanches, Gecko, Semen Allii Tuberosi, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, Fructus Corni, Cortex Eucommiae(processed with salt) etc. totally 20 kinds of Chinese crude drugs be the pharmaceutical preparation of making of main active component and preparation method.
Background technology
According to the yin-yang theory of Chinese medicine, negative and positive have limitlessly detachable, the first acquired essence of kidney, and essence belongs to cloudy, so claim cloudy essence, QI belonging to YANG, so claim yang-energy, is collectively referred to as cloudy the vivid YANG QI.Kidney essense belongs to cloudy essence, again can forked rubbing again among cloudy essence, wherein can be divided into again cloudy smart the yang aspect of yang essence and the moon essence the yin aspect of yin smart.When cloudy smart the yang aspect of yang damage of essence is empty, have soreness of waist and knee joint, spinal column wither the Symptoms such as sour tired out, the fatiguability of weak, bone, have soreness of the waist and knees, talalgia, dry mouth and tougue when cloudy smart the yin aspect of yin damage of essence is empty, quench one's thirst, the Symptoms such as insomnia and dreamful sleep.How in close relations with insufficiency of kidney-YANG when cloudy smart the yang aspect of yang damage of essence is empty, how in close relations with deficiency of the kidney yin when cloudy smart the yin aspect of yin damage of essence is empty.So during insufficiency of kidney-YANG except the performance such as have fear of cold to be afraid of cold, often to wither with soreness of waist and knee joint, spinal column the symptoms such as sour tired out, the fatiguability of weak, bone, during deficiency of the kidney yin except having that the deficiency of YIN is scorching and waiting performance, often with soreness of the waist and knees, talalgia, dry mouth and tougue, the symptom such as to quench one's thirst.
China's traditional Chinese medical science is thought, the clinical manifestation of insufficiency of kidney-YANG has many aspects, as: spiritlessness and weakness, lassitude, vigor are low, fatiguability; Fear of cold is afraid of cold, coolness of extremities (severe one is also cool for summer), health are sent out heavy; Soreness of waist and knee joint, back cold type of pain, muscles and bones are withered soft; Sexual hypofunction, sexual impotence, premature ejaculation, easily trouble prostatitis etc.; Clear urine in large amounts, the heeltap not to the utmost, oliguria or nocturia; Auditory dysesthesia or tinnitus; Hypomnesis, drowsiness, dreaminess, spontaneous perspiration; Easy trouble lumbago, arthralgia etc.; Easy trouble osteoporosis, cervical spondylosis, lumbar spondylosis etc.; Dyspnea due to deficiency is breathed hard, cough with asthma rale; Morning diarrhea, or constipation; Body edema, below waist more so, lower limbs edema; Lower abdomen traction testis falling inflation pain, or scrotum shrinks, meet cold what for, heat is then delayed; Beard and hair easily comes off, morning white; Body puffiness due to deficiency or weakness and emaciation; Then color is bluish white unglazed or dark to be reflected in face.
The clinical manifestation of syndrome of deficiency of kidney-YANG may be summarized to be ten aspects:
1. soreness of the waist and knees and pain; 2. impotence in male premature ejaculation, woman's infertility; 3. incessant chronic diarrhea, aqueous-grainy diarrhea, Diarrhoea; 4. frequent micturition, long clearly, frequent urination at night; 5. edema; 6. darkish complexion is without pool; 7. aversion to cold and cold limbs, lower limb are very; 8. lethargy; 9. pale complexion, the vertigo; 10. the fat tongue of light red tongue is white, deep and weak pulse and late.
Syndrome: soreness of the waist and knees and pain; Impotence in male premature ejaculation, woman's infertility; Aversion to cold and cold limbs, edema, be very below waist, lower limb are very; Pale complexion, the vertigo; Darkish complexion is without pool, frequent micturition, long clearly, frequent urination at night; The fat tongue of light red tongue is white, deep and weak pulse and late.
The general insufficiency of kidney-YANG rule for the treatment of: warming and recuperating the kidney-YANG.Main formula: JINGUI SHENQI WAN; Its prescription is Radix Rehmanniae, Rhizoma Dioscoreae, Fructus Corni (wine is processed), Poria, Cortex Moutan, Rhizoma Alismatis, Ramulus Cinnamomi, Radix Aconiti Lateralis Preparata (system), Radix Achyranthis Bidentatae (decaptitating), Semen Plantaginis (salt is processed).Adjuvant is Mel.
To suffer from a deficiency of the kidney the rule for the treatment of of having loose bowels: the kidney warming antidiarrheal.Main formula: SISHEN WAN; Its prescription is Semen Myristicae (stewing), Fructus Psoraleae (salt stir-fry), Fructus Schisandrae Chinensis (vinegar system), Fructus Evodiae (system), Fructus Jujubae (enucleation).
The edema due to deficiency of the kidney rule for the treatment of: warming the kidney to promote diuresis, main formula: Zhen Wu Tang, Decoction for strengthening the Spleen-Yang.Its prescription is Poria, Radix Paeoniae, Rhizoma Zingiberis Recens, Radix Aconiti Lateralis Preparata, the Rhizoma Atractylodis Macrocephalae.
The conventional Chinese medicine in China's Chinese crude drug with warming and recuperating the kidney-YANG drug action has: Cornu Cervi Pantotrichum, Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali, the Radix Paeoniae Alba, Poria, Fructus Corni, Rhizoma dioscoreae, Fructus Psoraleae, Fructus Lycii, Semen Cuscutae, Cordyceps, Solenognathus, Hippocampus etc.In kidney-nourishing tcm drug, Solenognathus, Gecko, Cornu Cervi Pantotrichum, Herba Epimedii, Herba Cistanches, Actinolitum, Herba Cynomorii, Semen Allii Tuberosi, Colla cornus cervi, the Cortex Eucommiae, Radix Morindae Officinalis, Rhizoma Drynariae, Rhizoma Cibotii, Rhizoma Curculiginis etc. have the effect of the kidney warming sun, Yiyang essence (cloudy smart the yang aspect of yang essence), Radix Rehmanniae Preparata, Radix Polygoni Multiflori Preparata, Fructus Lycii, Colla Plastri Testudinis, Fructus Ligustri Lucidi etc. have the effect of nourishing kidney-yin, tonifying YIN essence (cloudy smart the yin aspect of yin essence), therefore deficiency of kidney-essence is wanted will distinguish negative and positive during the kidney invigorating essence, select suitable Chinese crude drug to nourish.
The impact of general insufficiency of kidney-YANG on people is larger than deficiency of the kidney yin, and in human body, positive main the moon is from, interdependence between yin and yang.Insufficiency of kidney-YANG and deficiency of the kidney yin are not well-separated, no matter are deficiency of the kidney yin clinically, or insufficiency of kidney-YANG, if deficient often deficiency of YIN affecting YANG, deficiency of YANG affecting YIN to a certain extent.Therefore the insufficiency of kidney-YANG time has been grown and has had deficiency of the kidney yin symptom, so tonifying kidney-yin of must holding concurrently when kidney-replenishing, accomplishes treating YANG within YIN; And when tonifying kidney-yin can not simply only with the medicine of tonifying kidney-yin.
The present invention aims to provide one and utilizes Traditional Chinese medical theory and Chinese medicine method for making, in conjunction with modern Chinese medicine production technology, is the compound Chinese medicinal preparation that main active component is made with several kinds of Chinese medicinal materials; Its function is mainly warming and recuperating the kidney-YANG with curing mainly, and be applicable to syndrome of deficiency of kidney-YANG, disease sees spiritlessness and weakness, soreness of the waist and knees, dizzy spontaneous perspiration, aversion to cold and cold limbs, diarrhea before dawn, nocturia frequency.
Summary of the invention
One. prescription
The object of the present invention is to provide a kind of is compound preparation of making of main active component and preparation method thereof with several kinds of Chinese medicinal materials.Specifically, exactly with Radix Ginseng, Radix Codonopsis, the Radix Astragali, Cornu Cervi Pantotrichum, Cortex Cinnamomi, Herba Epimedii, Herba Cynomorii, Rhizoma Curculiginis, Radix Aconiti Lateralis Preparata, Fructus Lycii, Radix Morindae Officinalis, Herba Cistanches, Gecko, Semen Allii Tuberosi, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, Fructus Corni, Cortex Eucommiae(processed with salt) totally 20 kinds of Chinese crude drugs be the compound medicinal formulation that main active component is made, be mainly used in syndrome of deficiency of kidney-YANG clinically, disease sees spiritlessness and weakness, soreness of the waist and knees, dizzy spontaneous perspiration, aversion to cold and cold limbs, diarrhea before dawn, nocturia frequency.
The present invention is Radix Ginseng, Radix Codonopsis, the Radix Astragali, Cornu Cervi Pantotrichum, Cortex Cinnamomi, Herba Epimedii, Herba Cynomorii, Rhizoma Curculiginis, Radix Aconiti Lateralis Preparata, Fructus Lycii, Radix Morindae Officinalis, Herba Cistanches, Gecko, Semen Allii Tuberosi, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, Fructus Corni, Cortex Eucommiae(processed with salt) except totally 20 kinds of Chinese crude drugs except main active component, also comprises the conventional adjuvants such as the correctives needed for pharmaceutical preparation, antiseptic, stabilizing agent, diluent, binding agent, wetting agent, disintegrating agent, lubricant.
Content of the present invention except comprise by Radix Ginseng, Radix Codonopsis, the Radix Astragali, Cornu Cervi Pantotrichum, Cortex Cinnamomi, Herba Epimedii, Herba Cynomorii, Rhizoma Curculiginis, Radix Aconiti Lateralis Preparata, Fructus Lycii, Radix Morindae Officinalis, Herba Cistanches, Gecko, Semen Allii Tuberosi, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, Fructus Corni, Cortex Eucommiae(processed with salt) totally 20 kinds of Chinese crude drugs make except compound medicinal formulation, also comprise the production technology using common drug pharmaceutical adjunct useful in preparing drug formulations.
The object of the invention is to be completed by following technical proposals.
A compound Chinese medicinal preparation for the kidney invigorating, is characterized in that: form by weight primarily of following traditional Chinese medicines material:
Sequence number Component Part by weight
1 Radix Ginseng 1.5 ~ 6 parts
2 Radix Codonopsis 1 ~ 4 part
3 The Radix Astragali 3.5 ~ 15 parts
4 Cornu Cervi Pantotrichum 0.2 ~ 1 part
5 Cortex Cinnamomi 1 ~ 4 part
6 Herba Epimedii 3 ~ 12 parts
7 Herba Cynomorii 1 ~ 4 part
8 Rhizoma Curculiginis 1 ~ 5 part
9 Radix Aconiti Lateralis Preparata 1 ~ 5 part
10 Fructus Lycii 5 ~ 20 parts
11 Radix Morindae Officinalis 1.5 ~ 6 parts
12 Herba Cistanches 1 ~ 4 part
13 Gecko 1 ~ 4 part
14 Semen Allii Tuberosi 1 ~ 5 part
15 Radix Angelicae Sinensis 2 ~ 8 parts
16 The Radix Paeoniae Alba 1 ~ 5 part
17 Radix Rehmanniae Preparata 3 ~ 12 parts
18 Fructus Schisandrae Chinensis 1 ~ 4 part
19 Fructus Corni 1 ~ 4 part
20 Cortex Eucommiae(processed with salt) 2 ~ 8 parts
Add pharmaceutic adjuvant correctives, antiseptic, stabilizing agent, diluent, binding agent, wetting agent, disintegrating agent, the lubricant needed for pharmaceutical preparation, make oral solutions, tablet, capsule or granule.
The preferred formula of the present invention forms by weight primarily of following traditional Chinese medicines material:
Sequence number Component Part by weight
1 Radix Ginseng 3 parts
2 Radix Codonopsis 2 parts
3 The Radix Astragali 7.5 part
4 Cornu Cervi Pantotrichum 0.5 part
5 Cortex Cinnamomi 2 parts
6 Herba Epimedii 6 parts
7 Herba Cynomorii 2 parts
8 Rhizoma Curculiginis 2.5 part
9 Radix Aconiti Lateralis Preparata 2.5 part
10 Fructus Lycii 10 parts
11 Radix Morindae Officinalis 3 parts
12 Herba Cistanches 2 parts
13 Gecko 2 parts
14 Semen Allii Tuberosi 2.5 part
15 Radix Angelicae Sinensis 4 parts
16 The Radix Paeoniae Alba 2.5 part
17 Radix Rehmanniae Preparata 6 parts
18 Fructus Schisandrae Chinensis 2 parts
19 Fructus Corni 2 parts
20 Cortex Eucommiae(processed with salt) 4 parts
Add pharmaceutic adjuvant correctives, antiseptic, stabilizing agent, diluent, binding agent, wetting agent, disintegrating agent, the lubricant needed for pharmaceutical preparation, make oral solutions, tablet, tablet, capsule or granule.
Two. preparation technology
Oral liquid process of the present invention:
1) take 20 taste Chinese crude drugs described in prescription list by recipe quantity, clean respectively, sieve, sterilizing;
2) get Radix Angelicae Sinensis, Cortex Cinnamomi adds 3 times of water, boil 3 hours, collect volatile oil simultaneously; Aqueous solution and the other containers hold of medicinal residues, for subsequent use;
3) get Radix Ginseng, Radix Codonopsis, Cornu Cervi Pantotrichum, Gecko, the Radix Paeoniae Alba 5 taste Chinese crude drug pulverize as coarse powder, add 80% alcohol reflux 3 times, each 8 times amount, each 3 hours, merge ethanol extract, filter, filtrate is for subsequent use.
4) by 3) in medicinal residues and the Radix Astragali, Herba Epimedii, Herba Cynomorii, Rhizoma Curculiginis, Radix Aconiti Lateralis Preparata, Fructus Lycii, Radix Morindae Officinalis, Herba Cistanches, Semen Allii Tuberosi, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, Fructus Corni, Cortex Eucommiae(processed with salt) 13 taste Chinese crude drug merge, add above-mentioned Radix Angelicae Sinensis, Cortex Cinnamomi medicinal residues, decoct with water 3 times, add 5 times of water gagings at every turn, each decoction 2 hours, collecting decoction, filters, the aqueous solution that filtrate and Radix Angelicae Sinensis, Cortex Cinnamomi are distilled merges, and being concentrated into relative density is 1.20(80 DEG C) clear paste.
5) gained clear paste is added ethanol and make to be 60%, to leave standstill 48 hours, filter containing amount of alcohol, filtrate and above-mentioned Radix Ginseng, Radix Codonopsis, Cornu Cervi Pantotrichum, Gecko, Radix Paeoniae Alba ethanol extract merge, reclaim ethanol to relative density be 1.05(80 DEG C), add required pharmaceutic adjuvant correctives, antiseptic, stabilizing agent and 2) in volatile oil, add water standardize solution, stir, leave standstill, filter with kieselguhr, fill, sterilizing, obtains solution finished product.
Tablet of the present invention, capsule and granule production technology:
1) take 20 taste Chinese crude drugs described in prescription list by recipe quantity, clean respectively, sieve, sterilizing;
2) get Radix Angelicae Sinensis, Cortex Cinnamomi adds 3 times of water, boil 3 hours, collect volatile oil simultaneously; Aqueous solution and the other containers hold of medicinal residues, for subsequent use;
3) get Radix Ginseng, Radix Codonopsis, Cornu Cervi Pantotrichum, Gecko, the Radix Paeoniae Alba 5 taste Chinese crude drug pulverize as coarse powder, add 80% alcohol reflux 3 times, each 8 times amount, each 3 hours, merge ethanol extract, filter, filtrate is for subsequent use.
4) by 3) in medicinal residues and the Radix Astragali, Herba Epimedii, Herba Cynomorii, Rhizoma Curculiginis, Radix Aconiti Lateralis Preparata, Fructus Lycii, Radix Morindae Officinalis, Herba Cistanches, Semen Allii Tuberosi, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, Fructus Corni, Cortex Eucommiae(processed with salt) 13 taste Chinese crude drug merge, add above-mentioned Radix Angelicae Sinensis, Cortex Cinnamomi medicinal residues, decoct with water 3 times, add 5 times of water gagings at every turn, each decoction 2 hours, collecting decoction, filters, the aqueous solution that filtrate and Radix Angelicae Sinensis, Cortex Cinnamomi are distilled merges, and being concentrated into relative density is 1.20(80 DEG C) clear paste.
5) gained clear paste is added ethanol and make to be 60%, to leave standstill 48 hours, filter containing amount of alcohol, filtrate and above-mentioned Radix Ginseng, Radix Codonopsis, Cornu Cervi Pantotrichum, Gecko, Radix Paeoniae Alba ethanol extract merge, reclaim ethanol to relative density be 1.05(80 DEG C) clear paste, add 2) in volatile oil, stir.Vacuum drying to moisture is the blocks of solid of 8%.
6) blocks of solid is moistening with the alcoholic solution of 75-85%, fully stir 30 minutes, make mix homogeneously; Wet granulation, granulate after dry; Add required pharmaceutic adjuvant correctives, diluent, binding agent, wetting agent, disintegrating agent, lubricant successively, make tablet, capsule or granule.
Required pharmaceutic adjuvant in production technology of the present invention refers to correctives, antiseptic, stabilizing agent, diluent, binding agent, wetting agent, disintegrating agent, lubricant.
Correctives refers to one or more in Mel, sucrose, Aspartane, saccharin sodium, sucralose.
Antiseptic refers to one or more in benzoic acid, sodium benzoate, sorbic acid, methyl hydroxybenzoate, ethyl hydroxybenzoate.
Stabilizing agent refers to one or more in Macrogol 200, PEG400, polyethylene glycol-800, polyoxyethylene sorbitan monoleate.
Diluent refers to one or more in starch, pregelatinized Starch, lactose, dextrin, microcrystalline Cellulose, mannitol, Sorbitol, calcium sulfate, calcium bisulfate.
Binding agent refers to one or more in starch slurry, hydroxy methocel, polyvidone, gelatin, Polyethylene Glycol.
Wetting agent refers to ethanol.
Disintegrating agent refers to one or more in Sodium Hydroxymethyl Stalcs, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone.
Lubricant refers to one or more in magnesium stearate, Pulvis Talci, micropowder silica gel, hydrogenated vegetable oil.
Three. quality control
The primary quality measure of product of the present invention is to contain ginsenoside Rg 1(C 42h 72o 14) and ginsenoside Re (C 48h 82o 18) total amount, the every ml of oral liquid is no less than 25 μ g; Every sheet (grain, bag) of tablet, capsule and granule is containing ginsenoside Rg 1(C 42h 72o 14) and ginsenoside Re (C 48h 82o 18) total amount, be no less than 250 μ g.
Assay method: according to high performance liquid chromatography (Chinese Pharmacopoeia version in 2010 annex I J)
Be filler with octadecylsilane chemically bonded silica; Acetonitrile-0.05% phosphoric acid (18:82) is mobile phase; Determined wavelength is 203nm.Theoretical cam curve calculates should be not less than 2500 by ginsenoside Re peak.Precision takes ginsenoside Rg 1with Re reference substance, add the solution that methanol makes every ml0.15mg, 0.1mg respectively, in contrast product solution.Precision takes this product containing Rg 1(C 42h 72o 14) and ginsenoside Re (C 48h 82o 18) total amount be about 1.25mg amount product of the present invention, extract 4 times in order to water saturated n-butyl alcohol jolting, each 30ml, wash 2 times with ammonia solution, discard ammonia washing liquid.N-butyl alcohol liquid puts evaporate to dryness in water-bath, residue add water 5ml dissolve, with D 101resin absorption, uses 50ml water elution, discards eluent, continue with 70% ethanol 80ml eluting, collect eluent, put evaporate to dryness in water-bath, residue adds methanol and dissolves in right amount, moves in 5ml measuring bottle, adds methanol to scale; Shake up, filter, subsequent filtrate is need testing solution.Draw above-mentioned reference substance solution and each 5 μ l of need testing solution respectively, injection liquid chromatography, measure, to obtain final product.
Portioned product assay result of the present invention:
By carrying out the embodiment of the present invention of continuous 9 batches, obtaining the product of oral liquid, each 3 lot numbers of Tablet and Capsula agent, through inspection, all meeting the quality criteria requirements that the present invention works out.Illustrate that present invention process is stable, reliable, the content of 3 lot numbers of each dosage form is basically identical, illustrates that preparation technology of the present invention is reproducible.
Portioned product study on the stability result of the present invention:
Investigation condition: according to the condition of " Chinese Pharmacopoeia " version in 2010 two annex XIX C " crude drug and pharmaceutical preparation stability test guideline " defined, product is pressed commercially available back to place 6 months under the condition of temperature 40 ± 2 DEG C, relative humidity 75 ± 5%, inspection ginsenoside Rg 1with ginsenoside Re's total amount, and with 0 day results contrast, result is as follows:
The product of 9 lot numbers after accelerated stability investigates 6 months, its ginsenoside Rg 1compared with 0 day with ginsenoside Re's total amount, significant change does not occur, present invention process products obtained therefrom steady quality, controlled is described.
Four. clinical research
Major function of the present invention cures mainly as syndrome of deficiency of kidney-YANG, and disease sees spiritlessness and weakness, soreness of the waist and knees, dizzy antiperspirant, aversion to cold and cold limbs, diarrhea before dawn, nocturia frequency.We use the oral solutions in 9 of embodiment batches of products and tablet in hospital, select 67 routine insufficiency of kidney-YANG persons to treat, to observe clinical effectiveness.
Model case 1 Liu ××, man, 36 years old.Pain in the lumbar region, often dizzy, headache, soft foot is soft, nocturia, 8 ~ 10 times every night.Differential diagnosis in tcm is syndrome of deficiency of kidney-YANG.After oral liquor for spleen and kidney (20ml/ props up), daily 2 times, each one sooner or later, after 4 days except the slight soreness of waist, other symptoms are clearly better.
Model case 2 Lee ××, man, 57 years old.Weakness of the lower extremities, upper 3rd floors chest pains of breathing hard, easily sweating, weak obvious especially, insomnia has difficulty in going to sleep.Differential diagnosis in tcm is syndrome of deficiency of kidney-YANG.After kidney invigorating tablet, daily 2 times, each 2, after 7 days, symptom all disappears.
The clinical therapeutic efficacy of 67 routine Patients with Kidney-Yang Deficiency Syndromes is as follows altogether:
Total case load Cure number of cases Effective number of cases Effective number of cases Invalid number of cases Total effective rate
67 19 34 11 3 94.03%
Through using oral liquor for spleen and kidney clinical treatment statistics to 67 routine Patients with Kidney-Yang Deficiency Syndromes, its clinical cure 19 example, effective 34 examples, effective 11 examples, invalid 3 examples, total effective rate 94.03%.Illustrate that the present invention has higher curative effect in treatment syndrome of deficiency of kidney-YANG.
During clinical treatment observation, after 67 routine patient consumes, all do not find obvious untoward reaction, show that toxic and side effects of the present invention is low, safe and effective.
Five. feature of the present invention is:
1. the compound preparation of innovation
By totally 20 kinds of Chinese crude drugs employing Chinese medicine preparation technologies such as Radix Ginseng, Radix Codonopsis, the Radix Astragali, Cornu Cervi Pantotrichum, Cortex Cinnamomi, Herba Epimedii, Herba Cynomorii, Rhizoma Curculiginis, Radix Aconiti Lateralis Preparata, Fructus Lycii, Radix Morindae Officinalis, Herba Cistanches, Gecko, Semen Allii Tuberosi, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, Fructus Corni, Cortex Eucommiae(processed with salt), make the compound medicinal formulation of innovation, comprise oral liquid, tablet, capsule and granule.
2. the production technology of innovation
Production technology of the present invention combines Chinese medicine concocting method and advanced modern Chinese medicine extraction and preparation technique.
3. significant therapeutic effect
Through using oral liquor for spleen and kidney clinical treatment statistics to 67 routine Patients with Kidney-Yang Deficiency Syndromes, its clinical cure 19 example, effective 34 examples, effective 11 examples, invalid 3 examples, total effective rate 94.03%.
4. stable production technology
The oral liquid of the present invention's 9 lot numbers, Tablet and Capsula product after accelerated stability investigates 6 months, its ginsenoside Rg 1compared with 0 day with ginsenoside Re's total amount, significant change does not occur, illustrate that present invention process is ripe, reliable, products obtained therefrom steady quality, controlled.
Detailed description of the invention
Embodiment 1
Take Radix Ginseng 3g, Radix Codonopsis 2g, Radix Astragali 7.5g, Cornu Cervi Pantotrichum 0.5g, Cortex Cinnamomi 2g, Herba Epimedii 6g, Herba Cynomorii 2g, Rhizoma Curculiginis 2.5g, Radix Aconiti Lateralis Preparata 2.5g, Fructus Lycii 10g, Radix Morindae Officinalis 3g, Herba Cistanches 2g, Gecko 2g, Semen Allii Tuberosi 2.5g, Radix Angelicae Sinensis 4g, Radix Paeoniae Alba 2.5g, Radix Rehmanniae Preparata 6g, Fructus Schisandrae Chinensis 2g, Fructus Corni 2g, Cortex Eucommiae(processed with salt) 4g totally 20 kinds of Chinese crude drugs respectively, according to aforementioned " oral liquid process of the present invention " described step, make 1000ml solution, be distributed into the oral liquor for spleen and kidney of 100 bottles of 10ml/ bottles or 50 bottles of 20ml/ bottles.
Embodiment 2
Take Radix Ginseng 6g, Radix Codonopsis 4g, Radix Astragali 7.5g, Cornu Cervi Pantotrichum 1g, Cortex Cinnamomi 3g, Herba Epimedii 4g, Herba Cynomorii 1g, Rhizoma Curculiginis 2.5g, Radix Aconiti Lateralis Preparata 2.5g, Fructus Lycii 8g, Radix Morindae Officinalis 3g, Herba Cistanches 2g, Gecko 1g, Semen Allii Tuberosi 2.5g, Radix Angelicae Sinensis 8g, Radix Paeoniae Alba 5g, Radix Rehmanniae Preparata 4g, Fructus Schisandrae Chinensis 2g, Fructus Corni 2g, Cortex Eucommiae(processed with salt) 3g totally 20 kinds of Chinese crude drugs respectively, according to aforementioned " oral liquid process of the present invention " described step, make 1000ml solution, be distributed into the oral liquor for spleen and kidney of 100 bottles of 10ml/ bottles or 50 bottles of 20ml/ bottles.
Embodiment 3
Take Radix Ginseng 3kg, Radix Codonopsis 2kg, Radix Astragali 7.5kg, Cornu Cervi Pantotrichum 0.5kg, Cortex Cinnamomi 2kg, Herba Epimedii 6kg, Herba Cynomorii 2kg, Rhizoma Curculiginis 2.5kg, Radix Aconiti Lateralis Preparata 2.5kg, Fructus Lycii 10kg, Radix Morindae Officinalis 3kg, Herba Cistanches 2kg, Gecko 2kg, Semen Allii Tuberosi 2.5kg, Radix Angelicae Sinensis 4kg, Radix Paeoniae Alba 2.5kg, Radix Rehmanniae Preparata 6kg, Fructus Schisandrae Chinensis 2kg, Fructus Corni 2kg, Cortex Eucommiae(processed with salt) 4kg totally 20 kinds of Chinese crude drugs respectively, according to aforementioned " oral liquid process of the present invention " described step, make 1000L solution, be distributed into the oral liquor for spleen and kidney of 100000 bottles of 10ml/ bottles or 50000 bottles of 20ml/ bottles.
Embodiment 4
Take Radix Ginseng 2kg, Radix Codonopsis 1kg, Radix Astragali 12kg, Cornu Cervi Pantotrichum 1kg, Cortex Cinnamomi 2kg, Herba Epimedii 4kg, Herba Cynomorii 2kg, Rhizoma Curculiginis 3kg, Radix Aconiti Lateralis Preparata 2.5kg, Fructus Lycii 15kg, Radix Morindae Officinalis 4kg, Herba Cistanches 3kg, Gecko 2kg, Semen Allii Tuberosi 4kg, Radix Angelicae Sinensis 2kg, Radix Paeoniae Alba 2.5kg, Radix Rehmanniae Preparata 6kg, Fructus Schisandrae Chinensis 1kg, Fructus Corni 2kg, Cortex Eucommiae(processed with salt) 3kg totally 20 kinds of Chinese crude drugs respectively, according to aforementioned " oral liquid process of the present invention " described step, make 1000L solution, be distributed into the oral liquor for spleen and kidney of 100000 bottles of 10ml/ bottles or 50000 bottles of 20ml/ bottles.
Embodiment 5
Take Radix Ginseng 3g, Radix Codonopsis 2g, Radix Astragali 7.5g, Cornu Cervi Pantotrichum 0.5g, Cortex Cinnamomi 2g, Herba Epimedii 6g, Herba Cynomorii 2g, Rhizoma Curculiginis 2.5g, Radix Aconiti Lateralis Preparata 2.5g, Fructus Lycii 10g, Radix Morindae Officinalis 3g, Herba Cistanches 2g, Gecko 2g, Semen Allii Tuberosi 2.5g, Radix Angelicae Sinensis 4g, Radix Paeoniae Alba 2.5g, Radix Rehmanniae Preparata 6g, Fructus Schisandrae Chinensis 2g, Fructus Corni 2g, Cortex Eucommiae(processed with salt) 4g totally 20 kinds of Chinese crude drugs respectively, according to aforementioned " tablet of the present invention, capsule and granule production technology " described step, make 100 or 50 kidney invigorating tablets.
Embodiment 6
Take Radix Ginseng 3g, Radix Codonopsis 2g, Radix Astragali 7.5g, Cornu Cervi Pantotrichum 0.5g, Cortex Cinnamomi 2g, Herba Epimedii 6g, Herba Cynomorii 2g, Rhizoma Curculiginis 2.5g, Radix Aconiti Lateralis Preparata 2.5g, Fructus Lycii 10g, Radix Morindae Officinalis 3g, Herba Cistanches 2g, Gecko 2g, Semen Allii Tuberosi 2.5g, Radix Angelicae Sinensis 4g, Radix Paeoniae Alba 2.5g, Radix Rehmanniae Preparata 6g, Fructus Schisandrae Chinensis 2g, Fructus Corni 2g, Cortex Eucommiae(processed with salt) 4g totally 20 kinds of Chinese crude drugs respectively; according to aforementioned " tablet of the present invention, capsule and granule production technology " described step, make 100 or 50 capsule for tonifying kidney.
Embodiment 7
Take Radix Ginseng 3g, Radix Codonopsis 2g, Radix Astragali 7.5g, Cornu Cervi Pantotrichum 0.5g, Cortex Cinnamomi 2g, Herba Epimedii 6g, Herba Cynomorii 2g, Rhizoma Curculiginis 2.5g, Radix Aconiti Lateralis Preparata 2.5g, Fructus Lycii 10g, Radix Morindae Officinalis 3g, Herba Cistanches 2g, Gecko 2g, Semen Allii Tuberosi 2.5g, Radix Angelicae Sinensis 4g, Radix Paeoniae Alba 2.5g, Radix Rehmanniae Preparata 6g, Fructus Schisandrae Chinensis 2g, Fructus Corni 2g, Cortex Eucommiae(processed with salt) 4g totally 20 kinds of Chinese crude drugs respectively, according to aforementioned " tablet of the present invention, capsule and granule production technology " described step, make 100 bags or 50 bags of Bushen granules.
Embodiment 8
Take Radix Ginseng 3kg, Radix Codonopsis 2kg, Radix Astragali 7.5kg, Cornu Cervi Pantotrichum 0.5kg, Cortex Cinnamomi 2kg, Herba Epimedii 6kg, Herba Cynomorii 2kg, Rhizoma Curculiginis 2.5kg, Radix Aconiti Lateralis Preparata 2.5kg, Fructus Lycii 10kg, Radix Morindae Officinalis 3kg, Herba Cistanches 2kg, Gecko 2kg, Semen Allii Tuberosi 2.5kg, Radix Angelicae Sinensis 4kg, Radix Paeoniae Alba 2.5kg, Radix Rehmanniae Preparata 6kg, Fructus Schisandrae Chinensis 2kg, Fructus Corni 2kg, Cortex Eucommiae(processed with salt) 4kg totally 20 kinds of Chinese crude drugs respectively, according to aforementioned " tablet of the present invention, capsule and granule production technology " described step, make 100000 or 50000 kidney invigorating tablets.
Embodiment 9
Take Radix Ginseng 3kg, Radix Codonopsis 2kg, Radix Astragali 7.5kg, Cornu Cervi Pantotrichum 0.5kg, Cortex Cinnamomi 2kg, Herba Epimedii 6kg, Herba Cynomorii 2kg, Rhizoma Curculiginis 2.5kg, Radix Aconiti Lateralis Preparata 2.5kg, Fructus Lycii 10kg, Radix Morindae Officinalis 3kg, Herba Cistanches 2kg, Gecko 2kg, Semen Allii Tuberosi 2.5kg, Radix Angelicae Sinensis 4kg, Radix Paeoniae Alba 2.5kg, Radix Rehmanniae Preparata 6kg, Fructus Schisandrae Chinensis 2kg, Fructus Corni 2kg, Cortex Eucommiae(processed with salt) 4kg totally 20 kinds of Chinese crude drugs respectively; according to aforementioned " tablet of the present invention, capsule and granule production technology " described step, make 100000 or 50000 capsule for tonifying kidney.
Embodiment 10
Take Radix Ginseng 1.5kg, Radix Codonopsis 1kg, Radix Astragali 4kg, Cornu Cervi Pantotrichum 0.3kg, Cortex Cinnamomi 1kg, Herba Epimedii 3kg, Herba Cynomorii 1kg, Rhizoma Curculiginis 1.5kg, Radix Aconiti Lateralis Preparata 1.5kg, Fructus Lycii 5kg, Radix Morindae Officinalis 1.5kg, Herba Cistanches 1kg, Gecko 1kg, Semen Allii Tuberosi 1.5kg, Radix Angelicae Sinensis 2kg, Radix Paeoniae Alba 1.5kg, Radix Rehmanniae Preparata 3kg, Fructus Schisandrae Chinensis 1kg, Fructus Corni 1kg, Cortex Eucommiae(processed with salt) 2kg totally 20 kinds of Chinese crude drugs respectively, according to aforementioned " tablet of the present invention, capsule and granule production technology " described step, make 100000 or 50000 kidney invigorating tablets.
Embodiment 11
Take Radix Ginseng 6kg, Radix Codonopsis 4kg, Radix Astragali 15kg, Cornu Cervi Pantotrichum 1kg, Cortex Cinnamomi 4kg, Herba Epimedii 12kg, Herba Cynomorii 4kg, Rhizoma Curculiginis 5kg, Radix Aconiti Lateralis Preparata 5kg, Fructus Lycii 18kg, Radix Morindae Officinalis 6kg, Herba Cistanches 4kg, Gecko 4kg, Semen Allii Tuberosi 5kg, Radix Angelicae Sinensis 8kg, Radix Paeoniae Alba 5kg, Radix Rehmanniae Preparata 12kg, Fructus Schisandrae Chinensis 4kg, Fructus Corni 4kg, Cortex Eucommiae(processed with salt) 8kg totally 20 kinds of Chinese crude drugs respectively, according to aforementioned " tablet of the present invention, capsule and granule production technology " described step, make 100000 or 50000 kidney invigorating tablets.
Embodiment 12
Take Radix Ginseng 1.5kg, Radix Codonopsis 1kg, Radix Astragali 4kg, Cornu Cervi Pantotrichum 0.3kg, Cortex Cinnamomi 1kg, Herba Epimedii 3kg, Herba Cynomorii 1kg, Rhizoma Curculiginis 1.5kg, Radix Aconiti Lateralis Preparata 1.5kg, Fructus Lycii 5kg, Radix Morindae Officinalis 1.5kg, Herba Cistanches 1kg, Gecko 1kg, Semen Allii Tuberosi 1.5kg, Radix Angelicae Sinensis 2kg, Radix Paeoniae Alba 1.5kg, Radix Rehmanniae Preparata 3kg, Fructus Schisandrae Chinensis 1kg, Fructus Corni 1kg, Cortex Eucommiae(processed with salt) 2kg totally 20 kinds of Chinese crude drugs respectively; according to aforementioned " tablet of the present invention, capsule and granule production technology " described step, make 100000 or 50000 capsule for tonifying kidney.
Embodiment 13
Take Radix Ginseng 6kg, Radix Codonopsis 4kg, Radix Astragali 15kg, Cornu Cervi Pantotrichum 1kg, Cortex Cinnamomi 4kg, Herba Epimedii 12kg, Herba Cynomorii 4kg, Rhizoma Curculiginis 5kg, Radix Aconiti Lateralis Preparata 5kg, Fructus Lycii 18kg, Radix Morindae Officinalis 6kg, Herba Cistanches 4kg, Gecko 4kg, Semen Allii Tuberosi 5kg, Radix Angelicae Sinensis 8kg, Radix Paeoniae Alba 5kg, Radix Rehmanniae Preparata 12kg, Fructus Schisandrae Chinensis 4kg, Fructus Corni 4kg, Cortex Eucommiae(processed with salt) 8kg totally 20 kinds of Chinese crude drugs respectively, according to aforementioned " tablet of the present invention, capsule and granule production technology " described step, make 100000 bags or 50000 bags of Bushen granules.
Embodiment 14
Take Radix Ginseng 6kg, Radix Codonopsis 4kg, Radix Astragali 15kg, Cornu Cervi Pantotrichum 1kg, Cortex Cinnamomi 4kg, Herba Epimedii 12kg, Herba Cynomorii 4kg, Rhizoma Curculiginis 5kg, Radix Aconiti Lateralis Preparata 5kg, Fructus Lycii 18kg, Radix Morindae Officinalis 6kg, Herba Cistanches 4kg, Gecko 4kg, Semen Allii Tuberosi 5kg, Radix Angelicae Sinensis 8kg, Radix Paeoniae Alba 5kg, Radix Rehmanniae Preparata 12kg, Fructus Schisandrae Chinensis 4kg, Fructus Corni 4kg, Cortex Eucommiae(processed with salt) 8kg totally 20 kinds of Chinese crude drugs respectively, according to aforementioned " oral liquid process of the present invention " described step, make 1000L solution, be distributed into the oral liquor for spleen and kidney of 100000 bottles of 10ml/ bottles or 50000 bottles of 20ml/ bottles.
Embodiment 15
Take Radix Ginseng 1.5kg, Radix Codonopsis 1kg, Radix Astragali 4kg, Cornu Cervi Pantotrichum 0.3kg, Cortex Cinnamomi 1kg, Herba Epimedii 3kg, Herba Cynomorii 1kg, Rhizoma Curculiginis 1.5kg, Radix Aconiti Lateralis Preparata 1.5kg, Fructus Lycii 5kg, Radix Morindae Officinalis 1.5kg, Herba Cistanches 1kg, Gecko 1kg, Semen Allii Tuberosi 1.5kg, Radix Angelicae Sinensis 2kg, Radix Paeoniae Alba 1.5kg, Radix Rehmanniae Preparata 3kg, Fructus Schisandrae Chinensis 1kg, Fructus Corni 1kg, Cortex Eucommiae(processed with salt) 2kg totally 20 kinds of Chinese crude drugs respectively, according to aforementioned " oral liquid process of the present invention " described step, make 1000L solution, be distributed into the oral liquor for spleen and kidney of 100000 bottles of 10ml/ bottles or 50000 bottles of 20ml/ bottles.

Claims (8)

1. a compound Chinese medicinal preparation for the kidney invigorating, is characterized in that: form by weight primarily of following traditional Chinese medicines material:
。
2. compound Chinese medicinal preparation according to claim 1, is characterized in that: preferred formula forms by weight primarily of following traditional Chinese medicines material:
。
3. compound Chinese medicinal preparation according to claim 2, is characterized in that: the production technology of its oral liquid is:
1) take 20 taste Chinese crude drugs described in prescription list by recipe quantity, clean respectively, sieve, sterilizing;
2) get Radix Angelicae Sinensis, Cortex Cinnamomi adds 3 times of water, boil 3 hours, collect volatile oil simultaneously; Aqueous solution and the other containers hold of medicinal residues, for subsequent use;
3) get Radix Ginseng, Radix Codonopsis, Cornu Cervi Pantotrichum, Gecko, the Radix Paeoniae Alba 5 taste Chinese crude drug pulverize as coarse powder, add 80% alcohol reflux 3 times, each 8 times amount, each 3 hours, merge ethanol extract, filter, filtrate is for subsequent use;
4) by 3) in medicinal residues and the Radix Astragali, Herba Epimedii, Herba Cynomorii, Rhizoma Curculiginis, Radix Aconiti Lateralis Preparata, Fructus Lycii, Radix Morindae Officinalis, Herba Cistanches, Semen Allii Tuberosi, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, Fructus Corni, Cortex Eucommiae(processed with salt) 13 taste Chinese crude drug merge, add above-mentioned Radix Angelicae Sinensis, Cortex Cinnamomi medicinal residues, decoct with water 3 times, add 5 times of water gagings at every turn, each decoction 2 hours, collecting decoction, filters, the aqueous solution that filtrate and Radix Angelicae Sinensis, Cortex Cinnamomi are distilled merges, and being concentrated into relative density is 1.20(80 DEG C) clear paste;
5) gained clear paste is added ethanol and make to be 60%, to leave standstill 48 hours, filter containing amount of alcohol, filtrate and above-mentioned Radix Ginseng, Radix Codonopsis, Cornu Cervi Pantotrichum, Gecko, Radix Paeoniae Alba ethanol extract merge, reclaim ethanol to relative density be 1.05(80 DEG C), add required pharmaceutic adjuvant correctives, antiseptic, stabilizing agent and 2) in volatile oil, add water standardize solution, stir evenly evenly, leave standstill, filter with kieselguhr, fill, sterilizing, obtains solution finished product.
4. compound Chinese medicinal preparation according to claim 2, is characterized in that: its tablet, capsule and granule production technology are:
1) take 20 taste Chinese crude drugs described in prescription list by recipe quantity, clean respectively, sieve, sterilizing;
2) get Radix Angelicae Sinensis, Cortex Cinnamomi adds 3 times of water, boil 3 hours, collect volatile oil simultaneously; Aqueous solution and the other containers hold of medicinal residues, for subsequent use;
3) get Radix Ginseng, Radix Codonopsis, Cornu Cervi Pantotrichum, Gecko, the Radix Paeoniae Alba 5 taste Chinese crude drug pulverize as coarse powder, add 80% alcohol reflux 3 times, each 8 times amount, each 3 hours, merge ethanol extract, filter, filtrate is for subsequent use;
4) by 3) in medicinal residues and the Radix Astragali, Herba Epimedii, Herba Cynomorii, Rhizoma Curculiginis, Radix Aconiti Lateralis Preparata, Fructus Lycii, Radix Morindae Officinalis, Herba Cistanches, Semen Allii Tuberosi, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, Fructus Corni, Cortex Eucommiae(processed with salt) 13 taste Chinese crude drug merge, add above-mentioned Radix Angelicae Sinensis, Cortex Cinnamomi medicinal residues, decoct with water 3 times, add 5 times of water gagings at every turn, each decoction 2 hours, collecting decoction, filters, the aqueous solution that filtrate and Radix Angelicae Sinensis, Cortex Cinnamomi are distilled merges, and is concentrated into the clear paste that relative density is 1.20;
5) gained clear paste is added ethanol make containing amount of alcohol be 60%, leave standstill 48 hours, filter, filtrate and above-mentioned Radix Ginseng, Radix Codonopsis, Cornu Cervi Pantotrichum, Gecko, Radix Paeoniae Alba ethanol extract merge, reclaiming ethanol to relative density is the clear paste of 1.05, add 2) in volatile oil, stir, vacuum drying to moisture is the blocks of solid of 8%;
6) blocks of solid is moistening with the alcoholic solution of 75-85%, fully stir 30 minutes, make mix homogeneously; Wet granulation, granulate after dry; Add required pharmaceutic adjuvant correctives, diluent, binding agent, wetting agent, disintegrating agent, lubricant successively, make tablet, capsule or granule.
5. the compound Chinese medicinal preparation according to claim 1 or 2 or 3, is characterized in that: described correctives refers to one or more in Mel, sucrose, Aspartane, saccharin sodium, sucralose; Described antiseptic refers to one or more in benzoic acid, sodium benzoate, sorbic acid, methyl hydroxybenzoate, ethyl hydroxybenzoate; Described stabilizing agent refers to one or more in Macrogol 200, PEG400, polyethylene glycol-800, polyoxyethylene sorbitan monoleate.
6. the compound Chinese medicinal preparation according to claim 1 or 2 or 4, is characterized in that: described diluent refers to one or more in starch, pregelatinized Starch, lactose, dextrin, microcrystalline Cellulose, mannitol, Sorbitol, calcium sulfate, calcium bisulfate; Described binding agent refers to one or more in starch slurry, hydroxy methocel, polyvidone, gelatin, Polyethylene Glycol; Described wetting agent refers to ethanol.
7. the compound Chinese medicinal preparation according to claim 1 or 2 or 4, is characterized in that: described disintegrating agent refers to one or more in Sodium Hydroxymethyl Stalcs, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone.
8. the compound Chinese medicinal preparation according to claim 1 or 2 or 4, is characterized in that: described lubricant refers to one or more in magnesium stearate, Pulvis Talci, micropowder silica gel, hydrogenated vegetable oil.
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CN105311410A (en) * 2015-07-22 2016-02-10 刘鹏 Medicated liquor for treating waist and knee sour pain
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CN109745538A (en) * 2017-11-08 2019-05-14 陈冠卿 A kind of medical fluid for oral administration for treating the sombre disease of kidney-yang deficiency type
CN108567883A (en) * 2018-07-10 2018-09-25 左仁富 A kind of improvement male's sexual, constitutional Chinese medicine composition and preparation method
CN109820979A (en) * 2019-03-25 2019-05-31 黑龙江双兰星制药有限公司 A kind of pharmaceutical composition and preparation method thereof for treating kidney-yang deficiency
CN110787259A (en) * 2019-12-17 2020-02-14 李奇龙 Traditional Chinese medicine composition for improving male sexual function and application thereof
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CN114748571A (en) * 2022-03-18 2022-07-15 闵长青 Traditional Chinese medicine pill for male and preparation method thereof

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