CN106729404A - A kind of Chinese medicine preparation and its preparation technology for treating thyroid disease - Google Patents
A kind of Chinese medicine preparation and its preparation technology for treating thyroid disease Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
A kind of thyroid disease for the treatment of, its raw material is made up of prepared fleece flower root, the fruit of glossy privet, coix seed, the Radix Astragali, curcuma zedoary, stir-baked RHIZOMA SPARGANII with vinegar, ginseng, Radix Glycyrrhizae, oldenlandia diffusa, rhizoma dioscoreae nipponicae, and raw material weight proportioning of soup processed is 10 20 parts of prepared fleece flower root, 10 20 parts of the fruit of glossy privet, 10 15 parts of coix seed, 20 30 parts of the Radix Astragali, 10 20 parts of curcuma zedoary, 10 15 parts of stir-baked RHIZOMA SPARGANII with vinegar, 15 30 parts of ginseng, 36 parts of Radix Glycyrrhizae, 10 20 parts of oldenlandia diffusa, 10 20 parts of rhizoma dioscoreae nipponicae；The Chinese medicine preparation is convenient to take, steady quality, can be effectively retained the active ingredient in medicine.
Description
Technical field
The invention belongs to field of traditional Chinese, a kind of Chinese medicine preparation for treating thyroid disease and its preparation are specifically disclosed
Technique.
Background technology
In recent years, the thyroid disease incidence of disease rapidly rises, and is carried out according to Endocrine Society of Chinese Medical Association《Community occupies
People's thyroid disease epidemiology survey》Result shows that the illness rate of hyperthyroidism is 1.3%, and the illness rate that first subtracts is 6.5%, first shape
The illness rate of gland tubercle is 18.6%, and it is pernicious, that is, thyroid cancer to have 5%~15% in thyroid nodule.At present for first
The diseases such as shape adenoma, thyroid cancer and a part of nodular goiter, surgery excision is primary treatments.Postoperative recurrence
Probability is very high.Clinical application is mainly by suppressing medicine or the iodine -131 reduction thyroid function treatment first that thyroid hormone synthesizes
It is high.And the Thyroid Gland Swell adjoint to hyperthyroidism and expophthalmos, thyroid nodule, simple goiter are without specific drug.Chinese patent drug
In also to lack the Thyroid Gland Swell adjoint to hyperthyroidism, endocrine exophthalmos, thyroid nodule, simple goiter effective
Final drug.
The anti-Party A in Five Sacred Mountins is tested by the clinic of Shandong Prov. Hospital vice-president, director Zhao Jia armies of division of endocrinology teaching inventive
Just, as preparation in institute in the clinical practice more than ten years, and national inventing patent mandate was obtained in 2002（The patent No.：
ZL99112193.7）.The prescription is compound Chinese medicinal preparation, is mainly made up of Ten Herbs such as the Radix Astragali, ginsengs, supplementing qi and nourishing yin, work
Blood stagnation resolvation, softening and resolving hard mass, adjust immunologic function.Clinically it is mainly used in hyperthyroidism, tubercle and pure thyroid gland
Enlargement, endocrine exophthalmos etc..The prescription has abandoned the richness iodine Chinese medicine such as traditional marine alga, kelp, reaches qi and pathogen, and sample is simultaneous
The purpose controlled.The medicine prescription is unique, meets the modern study of pathogenesis to thyroid disease, and not only Endocrine has two-way tune
Section act on, also have certain effect to hemopoietic system and immune system, can increasing leukocyte, eliminate thyroid hormone secretion it is too high and
Use the side effect caused by antithyroid skin medicine.
The former anti-Party A in Five Sacred Mountins is using the formulation of traditional medicine pill in clinical practice.And pill is passed as one kind of Chinese medicine
System formulation, oral about 5~10g, has that single dose is excessive every time.And pill is used as a kind of conventional dosage forms, moisture,
Microbial limit value is higher, and product quality is difficult to control, and easily goes mouldy.And capsule, tablet etc. are used as a kind of modern medicines agent
Type, its drug ingedient is isolated from the outside, and avoids the influence of moisture, air, light, to bad odor, unstable medicine
Thing has a certain degree of masking, protection and stabilization.Medicine such as is not stressed at the influence of factor, so rapid in the gastrointestinal tract
Dispersion, dissolution and absorption, generally its action will be above pill.
Therefore, the anti-Party A in Five Sacred Mountins is developed into a kind of Modern New pharmaceutical dosage form, to reduce its single dose, and is improved
Its quality stability is extremely necessary.
The content of the invention
For the problem that prior art is present, it is an object of the invention to provide a kind of Chinese medicine system for treating thyroid disease
Agent and its preparation technology.The Chinese medicine preparation is convenient to take, steady quality, can be effectively retained the active ingredient in medicine.
To achieve the above object, the present invention provides following technical scheme：
A kind of Chinese medicine preparation for treating thyroid disease, its raw material is by prepared fleece flower root, the fruit of glossy privet, coix seed, the Radix Astragali, curcuma zedoary, vinegar
Rhizoma Sparganii, ginseng, Radix Glycyrrhizae, oldenlandia diffusa, rhizoma dioscoreae nipponicae composition；
Wherein, the raw material weight proportioning of soup processed is 10~20 parts of prepared fleece flower root, 10~20 parts of the fruit of glossy privet, 10~15 parts of coix seed, Huang
20~30 parts of stilbene, 10~20 parts of curcuma zedoary, 10~15 parts of stir-baked RHIZOMA SPARGANII with vinegar, 15~30 parts of ginseng, 3~6 parts of Radix Glycyrrhizae, oldenlandia diffusa 10~
20 parts, 10~20 parts of rhizoma dioscoreae nipponicae；
Preferably, in a kind of above-mentioned Chinese medicine preparation for treating thyroid disease, raw material weight proportioning of soup processed is prepared fleece flower root 10~15
Part, 10~17 parts of the fruit of glossy privet, 12~15 parts of coix seed, 20~25 parts of the Radix Astragali, 10~17 parts of curcuma zedoary, 12~15 parts of stir-baked RHIZOMA SPARGANII with vinegar, people
15~25 parts of ginseng, 3~5 parts of Radix Glycyrrhizae, 10~17 parts of oldenlandia diffusa, 10~18 parts of rhizoma dioscoreae nipponicae；
Preferably, in a kind of above-mentioned Chinese medicine preparation for treating thyroid disease, the raw material weight proportioning of soup processed is prepared fleece flower root 12
~15 parts, 12~17 parts of the fruit of glossy privet, 13~15 parts of coix seed, 20~23 parts of the Radix Astragali, 10~15 parts of curcuma zedoary, stir-baked RHIZOMA SPARGANII with vinegar 13~15
Part, 20~25 parts of ginseng, 3~4 parts of Radix Glycyrrhizae, 10~15 parts of oldenlandia diffusa, 12~18 parts of rhizoma dioscoreae nipponicae；
The meridian distribution of property and flavor and indication of the raw material employed in the present invention are as follows：
Ginseng：Sweet, slight bitter, tepor.Returns spleen, lung, the heart, kidney channel；Indication：Reinforce vital energy, veins takes off admittedly reinforces the spleen to benefit the lung, it is raw
Tianjin blood-nourishing, tranquilize the mind and promote the intelligence.To be taken off for physically weak, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung is breathed with cough, injury thirst, Heat Diabetes, gas
Anemia is empty, and prolonged illness void is thin, insomnia of palpitating with fear, impotence Gong Leng；
The Radix Astragali：It is sweet, tepor.Return lung, the spleen channel；Indication：Tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, blood-nourishing of promoting the production of body fluid, row is stagnant
Logical numbness, pus draining and toxin expelling, expelling pus and promoting granulation；For treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency
Spontaneous perspiration, deficiency of vital energy oedema, Heat Diabetes, blood deficiency chlorosis, hemiplegia, numbness pain is numb, ulcer is difficult to burst, burst for a long time and does not holds back；
Oldenlandia diffusa：It is bitter, sweet, tremble with fear；The thoughts of returning home, liver, the spleen channel；Indication：Clearing heat and detoxicating, carbuncle that disappears dissipating bind,；For abscess of throat,
Dyspnea and cough due to lung-heat, puckery pain of heat gonorrhea, jaundice with damp-heat pathogen and Several Kinds of Malignancy；External application can treat the diseases such as venomous snake bite, sore swells heat pain；
Rhizoma dioscoreae nipponicae：Sweet, hardship, temperature；Return liver, kidney, lung channel；Indication：Dispelling wind and eliminating dampness, channels sootheing and network vessel quickening, promoting blood circulation and stopping pain, cough-relieving is put down
Breathe heavily；For Bi condition, arthroncus, pain numbness, injury from falling down, acute waist sprain, cough and asthma；
Prepared fleece flower root：It is bitter, sweet, puckery, tepor.Return liver, the heart, kidney channel；Indication：Filling liver kidney, benefiting essence-blood, black beard and hair, strengthening the bones and muscles,
Change turbid lipid-loweringing；For blood deficiency chlorosis, dizziness and tinnitus, poliosis, soreness and weakness of waist and knees, extremity numbness, uterine bleeding under band, hyperlipidemia；
The fruit of glossy privet：Sweet, bitter, cold；Return liver and kidney channel；Indication：It is nourishing liver and kidney, improving eyesight black hair；For the deficiency of liver-yin and kidney-yin, dizziness ear
Ring, soreness and weakness of waist and knees, poliosis, mesh is secretly failed to understand, Heat Diabetes, osteopyrexia and fever；
Coix seed：It is sweet, light, it is cool；Returns spleen, stomach, lung channel；Indication：Clearing damp and promoting diuresis, invigorating the spleen to arrest diarrhea, eliminating impediment, apocenosis, removing toxic substances dissipates
Knot；For oedema, tinea pedis, difficult urination, splenasthenic diarrhea, arthritis with fixed pain caused by dampness contraction, lung carbuncle, acute appendicitis, wart, cancerous swelling；
Radix Glycyrrhizae：It is sweet, put down.The thoughts of returning home, lung, spleen, stomach；Indication：Invigorate the spleen and benefit qi , Cheongju thermal detoxifications, expelling phlegm and arresting coughing, relieving spasm to stop pain,
Coordinating the drug actions of a prescription；For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus,
Alleviate drug toxicity, strong；
Curcuma zedoary：Pungent, hardship, temperature.Return liver, spleen；Indication：Promoting the circulation of qi blood-breaking, Xiao Ji Zhi Tong；Yong Yu abdominal lump of mass in abdomen, blood stasis closed, chest
Numbness is pained, dyspepsia distending pain；
Stir-baked RHIZOMA SPARGANII with vinegar：Pungent, hardship, puts down.Return liver, the spleen channel；Indication：Blood-breaking, Xiao Ji Zhi Tong；Yong Yu abdominal lump of mass in abdomen, dysmenorrhoea, the stasis of blood
Blood Amenorrhea, chest impediment and cardialgia, dyspepsia distending pain.
Prepared by a kind of Chinese medicine preparation for treating thyroid disease of the present invention, its process is：Weigh in proportion appropriate
Prepared fleece flower root, the fruit of glossy privet, coix seed, the Radix Astragali, curcuma zedoary, stir-baked RHIZOMA SPARGANII with vinegar, ginseng, Radix Glycyrrhizae, oldenlandia diffusa, rhizoma dioscoreae nipponicae in 1-10
Kind, it is put into volatile oil extracting equipment, extract volatile oil；The dregs of a decoction and the remaining raw material for extracting are infiltrated with Extraction solvent；After running through,
Decocted；Collecting decoction, is concentrated；Gained medicinal extract is dried and crushed；Surplus stock is crushed；Then will
Extract powder and raw material powder mix, and add the volatile oil for extracting, and add proper auxiliary materials to be made preparation.
A kind of preparation technology of above-mentioned Chinese medicine preparation for treating thyroid disease, preferably weigh in proportion prepared fleece flower root,
4~9 kinds in the fruit of glossy privet, coix seed, the Radix Astragali, curcuma zedoary, stir-baked RHIZOMA SPARGANII with vinegar, ginseng, Radix Glycyrrhizae, oldenlandia diffusa, rhizoma dioscoreae nipponicae, it is put into volatilization
In oil extract equipment, volatile oil is extracted；
Described Extraction solvent is water, 10%~90% ethanol solution；Infiltrating time is 1~24 hour；
Described decoction temperature control is 60~100 DEG C, decocts number of times 1~3 time, each decocting time 1~4 hour；
Described condensing mode is that normal pressure is concentrated or concentrated under reduced pressure；Medicinal extract relative density after concentration is 1.25~1.35；
Described drying mode is the one kind in constant pressure and dry, drying under reduced pressure, freeze-drying, spray drying；Drying temperature is -40
~200 DEG C；Granularity after crushing is 10~300 mesh；
The grinding particle size of described surplus stock is 10~300 mesh；
Described preparation is the one kind in tablet, capsule, sustained release preparation, granule, oral liquid, supensoid agent.
The pharmaceutical preparation of above-mentioned oral administration, uses pharmaceutically useful diluent, such as filler in preparation process（Lactose,
Sucrose, mannitol, dextrin etc.）, adhesive（Such as pregelatinized starch, PVP, hydroxypropyl cellulose）, lubricant
（Stearic acid, polyethylene glycol, magnesium stearate, talcum powder, silica）, disintegrant（Such as starch, sodium carboxymethylcellulose）, profit
Lubrication prescription（Such as lauryl sodium sulfate）.
The present invention is had an advantageous effect in that：Prescription of the present invention is unique, meets the modern morbidity machine to thyroid disease
Reason research.And extracted the active principle in raw material using modern medicines preparation technique, it is maximum in concentration, drying process
The loss for reducing active principle of degree.It is made the modern medicines formulation for being easy to patient to carry and take.By accelerating 6
The moon, the study on the stability of long-term 12 months, the active ingredient in medicine do not change, uniform content stabilization, moisture, microorganism
Limit etc. has obtained preferable control.Farthest ensure that the quality and curative effect of medicine.
Specific embodiment
Raw materials used source and its place of production are as follows in following examples：
Ginseng：This product is Araliaceae ginsengPanax ginsengC.A.Mey. dry root and rhizome；The place of production is Jilin；
The Radix Astragali：This product is the legume film English Radix AstragaliAstragalusmembranaceus(Fisch.) dry root of Bge.；
The place of production is Gansu；
Oldenlandia diffusa：This product is madder wort oldenlandia diffusa（HedyotisdiffusaWilld）Dry herb；Produce
Ground is Jiangxi；
Rhizoma dioscoreae nipponicae：This product is Chinese yam plant dioscorea nipponicaDioscoreanipponicaThe dry rhizome of Makino；The place of production is the Liao Dynasty
Rather；
Coix seed：This product is grass Job's tearsCoixlacryma-jobiL.var.mayuen(Roman.) Stapf's is dry
Dry mature seed kernel；The place of production is Hunan；
Radix Glycyrrhizae：This product is glycyrrhizic legumeGlycyrrhizauralensisFisch. dry root and rhizome；The place of production is new
Boundary；
Prepared fleece flower root：This product is polygonum multiflorum thunbPolygonummuLtiflorumThe processing of dried root Thunb. adds
Work product；The place of production is Hubei；
The fruit of glossy privet：This product is Oleaceae plants glossy privetLigustrumlucidumAit. dry mature fruit.The place of production is Hubei；
Stir-baked RHIZOMA SPARGANII with vinegar：This product is Sparganiaceae plant rhizoma scirpiSparganiumstoloniferumBuch.-Ham. dry tuber
Preparation process product；The place of production is Hubei；
Curcuma zedoary：This product is zingiberaceous plant Guangxi zedoaryCurcumakwangsiensisThe drying of S.G.Lee et C.F.Liang
Rhizome；The place of production is Guangxi.
Embodiment 1：Granule
Prescription：
Prepared fleece flower root 10g, fruit of glossy privet 20g, coix seed 15g, Radix Astragali 20g, curcuma zedoary 15g, stir-baked RHIZOMA SPARGANII with vinegar 15g, Radix Glycyrrhizae 5g, oldenlandia
Careless 15g, rhizoma dioscoreae nipponicae 18g, ginseng 20g；
Technique：
By prepared fleece flower root, the fruit of glossy privet, coix seed, the Radix Astragali, curcuma zedoary, stir-baked RHIZOMA SPARGANII with vinegar, Radix Glycyrrhizae, oldenlandia diffusa, 9 kinds of rhizoma dioscoreae nipponicae in proportion
Weigh raw material, plus 10 times of water infiltrations 2 hours, decoct 3 times, 1 hour every time, temperature control was decocted at 95~100 DEG C, merge and decoct
Liquid, is concentrated under reduced pressure into relative density 1.35；Gained medicinal extract constant pressure and dry mode is dried, and drying temperature is 100 DEG C；Gained
Dry extract pulverizer is crushed and crosses 200 mesh sieves；Remaining ginseng pulverizer is crushed and crosses 200 mesh sieves；Add appropriate lactose system
Into particle.
Embodiment 2：Granule
Prescription：
Prepared fleece flower root 12g, fruit of glossy privet 17g, coix seed 13g, Radix Astragali 23g, curcuma zedoary 10g, stir-baked RHIZOMA SPARGANII with vinegar 12g, Radix Glycyrrhizae 6g, oldenlandia
Careless 17g, rhizoma dioscoreae nipponicae 20g, ginseng 25g；
Technique：
Prepared fleece flower root, the fruit of glossy privet, curcuma zedoary, stir-baked RHIZOMA SPARGANII with vinegar, 5 kinds of oldenlandia diffusa are weighed into raw material in proportion, volatile oil extracting is put into
In equipment, volatile oil is extracted；The dregs of a decoction and coix seed, the Radix Astragali, Radix Glycyrrhizae, rhizoma dioscoreae nipponicae add 10 times of 60% ethanol solution to infiltrate 10 hours, decoct
Boil 1 time, 4 hours used times, decoct temperature control at 80~85 DEG C, collecting decoction is concentrated under reduced pressure into relative density 1.25；Gained soaks
Cream drying under reduced pressure mode is dried, and drying temperature is 60 DEG C；Gained dry extract pulverizer is crushed and crosses 60 mesh sieves；It is remaining
Ginseng pulverizer is crushed and crosses 60 mesh sieves；Extract powder and ginseng pulverate are mixed, the volatile oil of extraction is added and is added appropriate sugarcane
Sugar is made particle.
Embodiment 3：Hard capsule
Prescription：
Prepared fleece flower root 20g, fruit of glossy privet 10g, coix seed 12g, Radix Astragali 30g, curcuma zedoary 20g, stir-baked RHIZOMA SPARGANII with vinegar 13g, Radix Glycyrrhizae 3g, oldenlandia
Careless 10g, rhizoma dioscoreae nipponicae 10g, ginseng 30g；
Technique：
By curcuma zedoary, stir-baked RHIZOMA SPARGANII with vinegar, oldenlandia diffusa, raw material is weighed in proportion, be put into volatile oil extracting equipment, extract volatile oil；
The dregs of a decoction and prepared fleece flower root, the fruit of glossy privet, the Radix Astragali, Radix Glycyrrhizae, rhizoma dioscoreae nipponicae add 10 times of 80% ethanol solution to infiltrate 24 hours, decoction 3 times, often
Secondary 2 hours, temperature control is decocted at 75~85 DEG C, collecting decoction is concentrated under reduced pressure into relative density 1.30；Gained medicinal extract is freezed
Drying mode is dried, and drying temperature is -40 DEG C；Gained dry extract pulverizer is crushed and crosses 100 mesh sieves；Remaining Job's tears
Benevolence, ginseng pulverizer are crushed and cross 100 mesh sieves；Extract powder and ginseng pulverate are mixed, the volatile oil of extraction is added and is added suitable
Measure sucrose, be made particle.Add proper lubrication agent and load softgel shell, obtain final product capsule.
Embodiment 4：Tablet
Prescription：
Prepared fleece flower root 15g, fruit of glossy privet 12g, coix seed 10g, Radix Astragali 25g, curcuma zedoary 17g, stir-baked RHIZOMA SPARGANII with vinegar 10g, Radix Glycyrrhizae 4g, oldenlandia
Careless 20g, rhizoma dioscoreae nipponicae 12g, ginseng 15g；
Technique：
Curcuma zedoary is weighed into raw material in proportion, is put into volatile oil extracting equipment, extract volatile oil；The dregs of a decoction and the fruit of glossy privet, coix seed,
The Radix Astragali, Radix Glycyrrhizae, rhizoma dioscoreae nipponicae, stir-baked RHIZOMA SPARGANII with vinegar, oldenlandia diffusa add 10 times of water infiltrations 12 hours, decoct 3 times, 3 hours every time, decoct temperature
At 95~100 DEG C, collecting decoction is concentrated under reduced pressure into relative density 1.30 for degree control；Gained medicinal extract is carried out with spray dried form
Dry, dry 200 DEG C of EAT, 80 DEG C of leaving air temp；Gained dry extract pulverizer is crushed and crosses 80 mesh sieves；How is residue system
The tuber of multiflower knotweed, ginseng pulverizer are crushed and cross 80 mesh sieves；Extract powder and medicinal material original powder are mixed, the volatile oil of extraction is added and is added
Appropriate amount of starch, it is made particle.Appropriate microcrystalline cellulose, sodium carboxymethyl starch, lactose, magnesium stearate are added, is well mixed, pressure
Piece is made, tablet finished product is obtained final product.
The study on the stability of embodiment 5
The obtained anti-first capsule in Five Sacred Mountins carries out study on the stability in choosing embodiment 3, as a result as follows：
Table 1：Acceleration, the long-time stability result of study of the anti-first capsule in Five Sacred Mountins
According to the requirement of NF standard, moisture must not exceed 9%, microbial limit requirement aerobic bacteria sum 104cfu/g；Mould
With yeast count 102cfu/g；EHEC must not be detected（1g）；Detection of Salmonella must not be detected（10g）；Bile tolerance Gram is cloudy
Property bacterium be less than 102cfu（g）；During thin layer differentiates and requires test sample chromatogram, in position corresponding with reference substance, control medicinal material chromatogram
On, show the spot of same color；Content requirement this product every is containing the Radix Astragali with Astragaloside IV（C41H68O14）Meter, must not be less than
1.00mg。
Result is investigated from aforementioned stable to can be seen that in accelerated test condition（40 ± 2 DEG C, RH75% ± 5%）Under carry out
Investigate, sampled in 0,1,2,3,6 months；In long term test condition（25 DEG C ± 2 DEG C, RH60% ± 10%）Under investigated, in 0,
3rd, 6,9,12 month inspections by sampling.Relevant item is detected.Result of the test shows that the anti-first capsule in Five Sacred Mountins is accelerated to test 6
Individual month, long-term 12 months study on the stability.Active ingredient in medicine does not change, uniform content stabilization.Other detections
Mesh has no significant change, and has good stability under test conditions.Illustrate capsule steady quality, the reliability.
Claims (11)
1. a kind of Chinese medicine preparation for treating thyroid disease, it is characterised in that its raw material by prepared fleece flower root, the fruit of glossy privet, coix seed,
The Radix Astragali, curcuma zedoary, stir-baked RHIZOMA SPARGANII with vinegar, ginseng, Radix Glycyrrhizae, oldenlandia diffusa, rhizoma dioscoreae nipponicae composition；Wherein, the raw material weight proportioning of soup processed is what is made
10 ~ 20 parts of the tuber of multiflower knotweed, 10 ~ 20 parts of the fruit of glossy privet, 10 ~ 15 parts of coix seed, 20 ~ 30 parts of the Radix Astragali, 10 ~ 20 parts of curcuma zedoary, stir-baked RHIZOMA SPARGANII with vinegar 10 ~ 15
Part, 15 ~ 30 parts of ginseng, 3 ~ 6 parts of Radix Glycyrrhizae, 10 ~ 20 parts of oldenlandia diffusa, 10 ~ 20 parts of rhizoma dioscoreae nipponicae.
2. the Chinese medicine preparation for the treatment of thyroid disease as claimed in claim 1, it is characterised in that the raw material weight proportioning of soup processed is
10 ~ 15 parts of prepared fleece flower root, 10 ~ 17 parts of the fruit of glossy privet, 12 ~ 15 parts of coix seed, 20 ~ 25 parts of the Radix Astragali, 10 ~ 17 parts of curcuma zedoary, stir-baked RHIZOMA SPARGANII with vinegar 12 ~
15 parts, 15 ~ 25 parts of ginseng, 3 ~ 5 parts of Radix Glycyrrhizae, 10 ~ 17 parts of oldenlandia diffusa, 10 ~ 18 parts of rhizoma dioscoreae nipponicae.
3. the Chinese medicine preparation for the treatment of thyroid disease as claimed in claim 1, it is characterised in that the raw material weight proportioning of soup processed is
12 ~ 15 parts of prepared fleece flower root, 12 ~ 17 parts of the fruit of glossy privet, 13 ~ 15 parts of coix seed, 20 ~ 23 parts of the Radix Astragali, 10 ~ 15 parts of curcuma zedoary, stir-baked RHIZOMA SPARGANII with vinegar 13 ~
15 parts, 20 ~ 25 parts of ginseng, 3 ~ 4 parts of Radix Glycyrrhizae, 10 ~ 15 parts of oldenlandia diffusa, 12 ~ 18 parts of rhizoma dioscoreae nipponicae.
4. a kind of preparation technology of the Chinese medicine preparation for treating thyroid disease, it is characterised in that process is：Weigh in proportion appropriate
Prepared fleece flower root, the fruit of glossy privet, coix seed, the Radix Astragali, curcuma zedoary, stir-baked RHIZOMA SPARGANII with vinegar, ginseng, Radix Glycyrrhizae, oldenlandia diffusa, rhizoma dioscoreae nipponicae in 1 ~ 10
Kind, it is put into volatile oil extracting equipment, extract volatile oil；The dregs of a decoction and the remaining raw material for extracting are infiltrated with Extraction solvent；After running through,
Decocted；Collecting decoction, is concentrated；Gained medicinal extract is dried and crushed；Surplus stock is crushed；Then will
Extract powder and raw material powder mix, and add the volatile oil for extracting, and add proper auxiliary materials to be made preparation.
5. the preparation technology of the Chinese medicine preparation of thyroid disease is treated as claimed in claim 4, it is characterised in that claimed in proportion
Take 4 ~ 9 in prepared fleece flower root, the fruit of glossy privet, coix seed, the Radix Astragali, curcuma zedoary, stir-baked RHIZOMA SPARGANII with vinegar, ginseng, Radix Glycyrrhizae, oldenlandia diffusa, rhizoma dioscoreae nipponicae
Kind, it is put into volatile oil extracting equipment, extract volatile oil.
6. the preparation technology of the Chinese medicine preparation of thyroid disease is treated as claimed in claim 4, it is characterised in that described carries
Solvent is taken for water, 10% ~ 90% ethanol solution；Infiltrating time is 1 ~ 24 hour.
7. the preparation technology of the Chinese medicine preparation of thyroid disease is treated as claimed in claim 4, it is characterised in that described decocts
Temperature control is boiled for 60 ~ 100 DEG C, number of times is decocted 1 ~ 3 time, each decocting time 1 ~ 4 hour.
8. the preparation technology of the Chinese medicine preparation of thyroid disease is treated as claimed in claim 4, it is characterised in that described is dense
Contracting mode is that normal pressure is concentrated or concentrated under reduced pressure；Medicinal extract relative density after concentration is 1.25 ~ 1.35.
9. the preparation technology of the Chinese medicine preparation of thyroid disease is treated as claimed in claim 4, it is characterised in that described is dry
Dry mode is the one kind in constant pressure and dry, drying under reduced pressure, freeze-drying, spray drying；Drying temperature is -40 ~ 200 DEG C；Crush
Granularity afterwards is 10 ~ 300 mesh.
10. the preparation technology of the Chinese medicine preparation of thyroid disease is treated as claimed in claim 4, it is characterised in that described is surplus
The grinding particle size of remaining raw material is 10 ~ 300 mesh.
The preparation technology of the Chinese medicine preparation of 11. treatment thyroid diseases as claimed in claim 4, it is characterised in that described system
Agent is the one kind in tablet, capsule, sustained release preparation, granule, oral liquid, supensoid agent.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109042916A (en) * | 2018-07-19 | 2018-12-21 | 安徽华禹食品有限公司 | A kind of peanut ready-mixed oil and its preparation process with prevention and treatment thyroid disease |
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| CN1271593A (en) * | 1999-04-23 | 2000-11-01 | 赵家军 | Medicine for treating thyropathy |
| CN101366847A (en) * | 2008-09-02 | 2009-02-18 | 赵玉梅 | Medicament for treating atrophic thyroiditis |
| CN102488812A (en) * | 2011-12-26 | 2012-06-13 | 株洲市中医伤科医院 | Bone fracture oral medicine, preparation method thereof, and application method thereof |
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| CN1271593A (en) * | 1999-04-23 | 2000-11-01 | 赵家军 | Medicine for treating thyropathy |
| CN101366847A (en) * | 2008-09-02 | 2009-02-18 | 赵玉梅 | Medicament for treating atrophic thyroiditis |
| CN102488812A (en) * | 2011-12-26 | 2012-06-13 | 株洲市中医伤科医院 | Bone fracture oral medicine, preparation method thereof, and application method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109042916A (en) * | 2018-07-19 | 2018-12-21 | 安徽华禹食品有限公司 | A kind of peanut ready-mixed oil and its preparation process with prevention and treatment thyroid disease |
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Application publication date: 20170531 |