CN104771444A - Bath preparation for treating insomnia and preparation method thereof - Google Patents
Bath preparation for treating insomnia and preparation method thereof Download PDFInfo
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- CN104771444A CN104771444A CN201510126551.7A CN201510126551A CN104771444A CN 104771444 A CN104771444 A CN 104771444A CN 201510126551 A CN201510126551 A CN 201510126551A CN 104771444 A CN104771444 A CN 104771444A
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Abstract
The invention discloses a bath preparation for treating insomnia and a preparation method thereof. The bath preparation is composed of the following raw materials in parts by weight: 6 to 120 parts of lotus plumule, 5 to 100 parts of red sage root, 5 to 100 parts of ligusticum wallichii, 5 to 100 parts of lavender, 3 to 80 parts of mint, and 3 to 80 parts of folium artemisiae argyi. The invention further discloses a specific preparation method of the pharmaceutical composition. The bath preparation has the functions of relaxing tendon, activating collaterals, calming the spirit, and tranquilizing, can treat and prevent insomnia, can also promote the local metabolism and activate the blood circulation, and has the advantages of simple and novel formula, low cost, prominent effect, and no side or toxic effect.
Description
Technical field
The present invention relates to a kind of bathing preparation with treatment or health-care effect, especially relate to a kind of bathing preparation and preparation method for the treatment of of insomnia patients.
Background technology
Have a sleepless night also known as must not crouch, insomnia, the unable to close the eyes, to be insomnia, be can not obtain with regular a kind of disease that ortho sleep is feature, clinical manifestation is difficulty falling asleep, often awakens, and sleeps and unstable or can not sleep after waking up again; Wake up morning too early; Night can not sleep; The length of one's sleep less than 5 hours, often with cardiopalmus, dreaminess, forgetful, hypomnesis, the syndrome group such as seminal emission and menoxenia.The crowd in the whole world about 30% has dyskoimesis according to statistics, and about more than 10% exists chronic insomnia.China's recent statistics display, insomnia sickness rate is up to more than 40%, and it seriously endangers the physical and mental health of people.Though western medicine is evident in efficacy, easily occur dizziness, drowsiness, weak and stupor and the untoward reaction such as respiration inhibition, life-time service also can produce toleration, dependency and additive.And the traditional Chinese medical science on the basis of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs to insomnia card treatment, have evident in efficacy, have no side effect, without the advantage of drug dependence.Therefore, the Chinese medicine study of insomnia card is the study hotspot of numerous scholar in recent years.
Chinese patent ZL201110383272.0 discloses a kind of medicine for the treatment of of insomnia patients, and this medicine is made up of Flos Albiziae 20 parts, Radix Angelicae Sinensis 20 parts, Radix Rehmanniae 18 parts, Radix Ophiopogonis 15 parts, Ramulus Cinnamomi 12 parts, Rhizoma Chuanxiong 12 parts, Radix Scrophulariae 15 parts, Fructus Ligustri Lucidi 9 parts, the Radix Astragali 9 parts, the Rhizoma Anemarrhenae 10 parts, Semen Ziziphi Spinosae 8 parts, the Rhizoma Pinelliae 8 parts, Rhizoma Cyperi 9 parts, Rhizoma Coptidis 7 parts, 7 parts, Poria and Semen Cassiae 5 parts; Chinese patent ZL201110250928.1 discloses a kind of foot bathing preparation for treating insomnia, and this foot-bath agent is made up of Fructus Evodiae 20-30 part, Fructus Schisandrae Chinensis 13-18 part, Rhizoma Zingiberis 8-12 part, Radix Notoginseng 8-12 part, Caulis et Folium Ammopiptanthi Mongolici 18-22 part, Cortex Albiziae 18-22 part, Rhizoma Fagopyri Dibotryis 20-30 part, Herba Plantaginis 20-30 part, Ramulus Cinnamomi 18-22 part, Radix Codonopsis 8-12 part, Rhizoma Coptidis 8-12 part, Radix Paeoniae Alba 6-10 part, Arillus Longan 20-30 part, Radix Glycyrrhizae 18-22 part, Radix Angelicae Sinensis 13-18 part, Radix Rehmanniae 13-18 part and Radix Bupleuri 8-12 part.Chinese patent ZL201210300676.3 discloses a kind of Chinese medicine decoction of Cure for insomnia, and this decoction is by Radix Codonopsis 13 ~ 18, Rhizoma Atractylodis Macrocephalae (parched) 13 ~ 18, Rhizoma Atractylodis (parched) 17 ~ 23, Poria 17 ~ 23, Herba Eupatorii 12 ~ 16, Fructus Piperis Longi 3 ~ 7, Semen Ginkgo core 3 ~ 7, jujube nucleus 18 ~ 25, Semen Platycladi 13 ~ 17, Caulis Polygoni Multiflori 28 ~ 34, Flos Albiziae 10 ~ 14, Radix Curcumae 14 ~ 16, Rhizoma Polygoni Cuspidati 14 ~ 16, Semen Armeniacae Amarum 8 ~ 11, Fructus Amomi Rotundus 10 ~ 13, Semen Coicis 28 ~ 34, Rhizoma Pinelliae Preparatum 8 ~ 12, Cortex Magnoliae Officinalis 8 ~ 12, Semen Nelumbinis 13 ~ 17, Radix Polygalae 16 ~ 20 and Radix Ophiopogonis 7 ~ 10 form.Although above-mentioned patent has good therapeutical effect to insomnia, the medicine comprised in above-mentioned patent is more, is difficult to control its impurity content, is difficult to realize industrialized great production when suitability for industrialized production.
Summary of the invention
One object of the present invention is to overcome the deficiencies in the prior art, provides a kind of composition simple, the pharmaceutical composition being used for the treatment of insomnia of novel formula, this pharmaceutical composition has that cost is low, good effect, have no side effect, can life-time service.
The object of the invention is to be achieved through the following technical solutions:
A bathing preparation for treatment of insomnia patients, this bathing preparation is made up of the raw material of following ratio of weight and number: Plumula Nelumbinis 6 ~ 120 parts, Radix Salviae Miltiorrhizae 5 ~ 100 parts, Rhizoma Chuanxiong 5 ~ 100 parts, lavandula angustifolia 5 ~ 100 parts, Herba Menthae 3 ~ 80 parts, Folium Artemisiae Argyi 3 ~ 80 parts.
Preferably, the ratio of weight and number of described each raw material is: Plumula Nelumbinis 10 ~ 100 parts, Radix Salviae Miltiorrhizae 8 ~ 80 parts, Rhizoma Chuanxiong 8 ~ 80 parts, lavandula angustifolia 8 ~ 80 parts, Herba Menthae 5 ~ 70 parts, Folium Artemisiae Argyi 5 ~ 70 parts.
Preferably, the ratio of weight and number of described each raw material is: Plumula Nelumbinis 20 ~ 80 parts, Radix Salviae Miltiorrhizae 15 ~ 60 parts, Rhizoma Chuanxiong 15 ~ 60 parts, lavandula angustifolia 15 ~ 60 parts, Herba Menthae 10 ~ 50 parts, Folium Artemisiae Argyi 10 ~ 50 parts.
Preferably, the ratio of weight and number of described each raw material is: Plumula Nelumbinis 30 ~ 60 parts, Radix Salviae Miltiorrhizae 20 ~ 50 parts, Rhizoma Chuanxiong 20 ~ 50 parts, lavandula angustifolia 20 ~ 50 parts, Herba Menthae 15 ~ 40 parts, Folium Artemisiae Argyi 15 ~ 40 parts.
Preferably, the ratio of weight and number of described each raw material is: Plumula Nelumbinis 12 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Chuanxiong 10 parts, lavandula angustifolia 10 parts, Herba Menthae 5 parts, Folium Artemisiae Argyi 5 parts.
Preferably, the ratio of weight and number of described each raw material is: Plumula Nelumbinis 20 parts, Radix Salviae Miltiorrhizae 15 parts, Rhizoma Chuanxiong 15 parts, lavandula angustifolia 15 parts, Herba Menthae 10 parts, Folium Artemisiae Argyi 10 parts.
A bathing preparation for treatment of insomnia patients, the ratio of weight and number of each raw material of this bathing preparation is: Plumula Nelumbinis extract 6 ~ 120 parts, Radix Salviae Miltiorrhizae extract 5 ~ 100 parts, Rhizoma Chuanxiong extract 5 ~ 100 parts, Herba Lysimachiae foenum-graeci extract 5 ~ 100 parts, Folium Menthae extract 3 ~ 80 parts, Folium Artemisiae Argyi extract 3 ~ 80 parts.
Preferably, the ratio of weight and number of described each raw material is: Plumula Nelumbinis extract 12 parts, Radix Salviae Miltiorrhizae extract 10 parts, Rhizoma Chuanxiong extract 10 parts, Herba Lysimachiae foenum-graeci extract 10 parts, Folium Menthae extract 5 parts, Folium Artemisiae Argyi extract 5 parts.
Prepare a method for above-mentioned arbitrary bathing preparation, the method comprises the steps: S1: take Plumula Nelumbinis by weight, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, lavandula angustifolia, Herba Menthae and Folium Artemisiae Argyi; S2: conveniently preparation method is prepared into bathing preparation.
Bathing preparation of the present invention is powder, granule, lotion, powder, decoction, unguentum, effervescent.
Extract of the present invention can be water extract, alcohol extract, wherein alcohol extract preferred alcohol extract.
Plumula Nelumbinis of the present invention is the green radicle in the middle of the mature seed of nymphaeaceae plant lotus, and bitter, cold, GUIXIN, kidney channel, have clearing away heart-fire for tranquillization, restoring normal coordination between the heart and kidney, the effect of unsmoothing the sperm and stopping bleeding; Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae, bitter, be slightly cold, and GUIXIN, Liver Channel, have stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire; Rhizoma Chuanxiong is the dry rhizome of samphire Rhizoma Chuanxiong, pungent, warm, returns liver, gallbladder, pericardium channel, has blood-activating and qi-promoting, the effect of wind-expelling pain-stopping; Lavandula angustifolia is that Labiatae lavandula angustifolia belongs to perennial evergreen undershrub, has the effects such as sedation-analgesia, anti-inflammation, spasmolytic convulsion, antiviral, anthelmintic; Herba Menthae is the dry aerial parts of Labiatae mint Herba Menthae, pungent, cool, returns lung, Liver Channel, has the effect of dispelling wind-heat, refresh oneself's rash; Folium Artemisiae Argyi is the dried leaves of feverfew Chinese mugwort, pungent, bitter, and temperature, returns liver,spleen,kidney warp, have warming the meridian for stopping bleeding, dispersing cold for relieving pain, external removing dampness to relieve itching.
For enabling above-mentioned dosage form realize, the acceptable adjuvant of pharmacy need be added when preparing these dosage forms, such as: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic etc., filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc., disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc., lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc., suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc., binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc., sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc., correctives comprises: sweeting agent and various essence, and antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene is fixed, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods.
The invention has the beneficial effects as follows:
Pharmaceutical composition of the present invention has effect of soothing the channels and quicking the network vessels, tranquillizing and allaying excitement, anti-inflammatory analgesic, has good preventive and therapeutic action to insomniac, and medicine of the present invention can enhance metabolism, increase blood circulation simultaneously.Show that of the present invention pharmaceutical composition xylol causes mice auricle swelling, Ovum Gallus domesticus album causes rat paw edema all has inhibitory action by pharmacodynamic study, show that pharmaceutical composition of the present invention has the effect of antiinflammatory.The present invention forms simply, novel formula, have with low cost, evident in efficacy, the advantage such as have no side effect.The novel formula of pharmaceutical composition of the present invention, raw material is simple, and have feature with low cost, preparation method of the present invention is simple to operate, is applicable to suitability for industrialized production.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is described in further detail, but protection scope of the present invention is not limited to the following stated.
Embodiment 1:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 6g, Radix Salviae Miltiorrhizae 5g, Rhizoma Chuanxiong 5g, lavandula angustifolia 5g, Herba Menthae 3g, Folium Artemisiae Argyi 3g.
Embodiment 2:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 120g, Radix Salviae Miltiorrhizae 100g, Rhizoma Chuanxiong 100g, lavandula angustifolia 100g, Herba Menthae 80g, Folium Artemisiae Argyi 80g.
Embodiment 3:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 10g, Radix Salviae Miltiorrhizae 8g, Rhizoma Chuanxiong 8g, lavandula angustifolia 8g, Herba Menthae 5g, Folium Artemisiae Argyi 5g.
Embodiment 4:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 100g, Radix Salviae Miltiorrhizae 80g, Rhizoma Chuanxiong 80g, lavandula angustifolia 80g, Herba Menthae 70g, Folium Artemisiae Argyi 70g.
Embodiment 5:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 20g, Radix Salviae Miltiorrhizae 15g, Rhizoma Chuanxiong 15g, lavandula angustifolia 15g, Herba Menthae 10g, Folium Artemisiae Argyi 10g.
Embodiment 6:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 80g, Radix Salviae Miltiorrhizae 60g, Rhizoma Chuanxiong 60g, lavandula angustifolia 60g, Herba Menthae 50g, Folium Artemisiae Argyi 50g.
Embodiment 7:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 30g, Radix Salviae Miltiorrhizae 20g, Rhizoma Chuanxiong 20g, lavandula angustifolia 20g, Herba Menthae 15g, Folium Artemisiae Argyi 15g.
Embodiment 8:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 60g, Radix Salviae Miltiorrhizae 50g, Rhizoma Chuanxiong 50g, lavandula angustifolia 50g, Herba Menthae 40g, Folium Artemisiae Argyi 40g.
Embodiment 9:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 12g, Radix Salviae Miltiorrhizae 10g, Rhizoma Chuanxiong 10g, lavandula angustifolia 10g, Herba Menthae 5g, Folium Artemisiae Argyi 5g.
Embodiment 10:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 20g, Radix Salviae Miltiorrhizae 15g, Rhizoma Chuanxiong 15g, lavandula angustifolia 15g, Herba Menthae 10g, Folium Artemisiae Argyi 10g.
Embodiment 11:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis extract 6g, Radix Salviae Miltiorrhizae extract 5g, Rhizoma Chuanxiong extract 5g, Herba Lysimachiae foenum-graeci extract 5g, Folium Menthae extract 3g, Folium Artemisiae Argyi extract 3g.
Embodiment 12:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis extract 120g, Radix Salviae Miltiorrhizae extract 100g, Rhizoma Chuanxiong extract 100g, Herba Lysimachiae foenum-graeci extract 100g, Folium Menthae extract 80g, Folium Artemisiae Argyi extract 80g.
Embodiment 13:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis water extract 10g, Danshen 8g, Rhizoma Chuanxiong 8g, lavender liquid extract 8g, aqua methnae extract 5g, Folium Artemisiae Argyi water extract 5g.
Embodiment 14:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis water extract 100g, Danshen 80g, Rhizoma Chuanxiong water extract 80g, lavender liquid extract 80g, aqua methnae extract 70g, Folium Artemisiae Argyi water extract 70g.
Embodiment 15:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis water extract 20g, Danshen 15g, Rhizoma Chuanxiong water extract 15g, lavender liquid extract 15g, aqua methnae extract 10g, Folium Artemisiae Argyi water extract 10g.
Embodiment 16:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis ethanol extraction 80g, Radix Salviae Miltiorrhizae ethanol extraction 60g, Rhizoma Chuanxiong ethanol extraction 60g, lavandula angustifolia ethanol extraction 60g, Herba Menthae ethanol extraction 50g, Folium Artemisiae Argyi ethanol extraction 50g.
Embodiment 17:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis ethanol extraction 30g, Radix Salviae Miltiorrhizae ethanol extraction 20g, Rhizoma Chuanxiong ethanol extraction 20g, lavandula angustifolia ethanol extraction 20g, Herba Menthae ethanol extraction 15g, Folium Artemisiae Argyi ethanol extraction 15g.
Embodiment 18:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis methanolic extract 60g, Radix Salviae Miltiorrhizae methanolic extract 50g, Rhizoma Chuanxiong methanolic extract 50g, lavandula angustifolia methanolic extract 50g, Herba Menthae methanolic extract 40g, Folium Artemisiae Argyi methanolic extract 40g.
Embodiment 19:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis methanolic extract 12g, Radix Salviae Miltiorrhizae methanolic extract 10g, Rhizoma Chuanxiong methanolic extract 10g, lavandula angustifolia methanolic extract 10g, Herba Menthae methanolic extract 5g, Folium Artemisiae Argyi methanolic extract 5g.
Embodiment 20:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis n-butanol extract 20g, Radix Salviae Miltiorrhizae n-butanol extract 15g, Rhizoma Chuanxiong n-butanol extract 15g, lavandula angustifolia n-butanol extract 15g, Herba Menthae n-butanol extract 10g, Folium Artemisiae Argyi n-butanol extract 10g.
Embodiment 21:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis ligroin extraction 6g, Radix Salviae Miltiorrhizae ligroin extraction 5g, Rhizoma Chuanxiong ligroin extraction 5g, lavandula angustifolia ligroin extraction 5g, Herba Menthae ligroin extraction 3g, Folium Artemisiae Argyi ligroin extraction 3g.
Embodiment 22:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis ligroin extraction 120g, Radix Salviae Miltiorrhizae ligroin extraction 100g, Rhizoma Chuanxiong ligroin extraction 100g, lavandula angustifolia ligroin extraction 100g, Herba Menthae ligroin extraction 80g, Folium Artemisiae Argyi ligroin extraction 80g.
Embodiment 23:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis ligroin extraction 10g, Radix Salviae Miltiorrhizae ligroin extraction 8g, Rhizoma Chuanxiong ligroin extraction 8g, lavandula angustifolia ligroin extraction 8g, Herba Menthae ligroin extraction 5g, Folium Artemisiae Argyi ligroin extraction 5g.
Embodiment 24:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis ligroin extraction 100g, Radix Salviae Miltiorrhizae ligroin extraction 80g, Rhizoma Chuanxiong ligroin extraction 80g, lavandula angustifolia ligroin extraction 80g, Herba Menthae ligroin extraction 70g, Folium Artemisiae Argyi ligroin extraction 70g.
Embodiment 25:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis ethyl acetate extract 20g, Radix Salviae Miltiorrhizae ethyl acetate extract 15g, Rhizoma Chuanxiong ethyl acetate extract 15g, lavandula angustifolia ethyl acetate extract 15g, menthoxy acetic acid ethyl ester extract 10g, Folium Artemisiae Argyi ethyl acetate extract 10g.
Embodiment 26:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis ethyl acetate extract 80g, Radix Salviae Miltiorrhizae ethyl acetate extract 60g, Rhizoma Chuanxiong ethyl acetate extract 60g, lavandula angustifolia ethyl acetate extract 60g, menthoxy acetic acid ethyl ester extract 50g, Folium Artemisiae Argyi ethyl acetate extract 50g.
Embodiment 27:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis ethyl acetate extract 30g, Radix Salviae Miltiorrhizae ethyl acetate extract 20g, Rhizoma Chuanxiong ethyl acetate extract 20g, lavandula angustifolia ethyl acetate extract 20g, menthoxy acetic acid ethyl ester extract 15g, Folium Artemisiae Argyi ethyl acetate extract 15g.
Embodiment 28:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis ethyl acetate extract 60g, Radix Salviae Miltiorrhizae ethyl acetate extract 50g, Rhizoma Chuanxiong ethyl acetate extract 50g, lavandula angustifolia ethyl acetate extract 50g, menthoxy acetic acid ethyl ester extract 40g, Folium Artemisiae Argyi ethyl acetate extract 40g.
Embodiment 29:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis ethyl acetate extract 12g, Radix Salviae Miltiorrhizae ethyl acetate extract 10g, Rhizoma Chuanxiong ethyl acetate extract 10g, lavandula angustifolia ethyl acetate extract 10g, menthoxy acetic acid ethyl ester extract 5g, Folium Artemisiae Argyi ethyl acetate extract 5g.
Embodiment 30:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis ethyl acetate extract 20g, Radix Salviae Miltiorrhizae ethyl acetate extract 15g, Rhizoma Chuanxiong ethyl acetate extract 15g, lavandula angustifolia ethyl acetate extract 15g, menthoxy acetic acid ethyl ester extract 10g, Folium Artemisiae Argyi ethyl acetate extract 10g.
Embodiment 31:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 6g, Radix Salviae Miltiorrhizae 5g, Rhizoma Chuanxiong 5g, lavandula angustifolia 5g, Herba Menthae 3g, and Folium Artemisiae Argyi 3g, is conventionally prepared into powder.
Embodiment 32:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 120g, Radix Salviae Miltiorrhizae 100g, Rhizoma Chuanxiong 100g, lavandula angustifolia 100g, Herba Menthae 80g, and Folium Artemisiae Argyi 80g, is conventionally prepared into powder.
Embodiment 33:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 10g, Radix Salviae Miltiorrhizae 8g, Rhizoma Chuanxiong 8g, lavandula angustifolia 8g, Herba Menthae 5g, and Folium Artemisiae Argyi 5g, is conventionally prepared into powder.
Embodiment 34:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 100g, Radix Salviae Miltiorrhizae 80g, Rhizoma Chuanxiong 80g, lavandula angustifolia 80g, Herba Menthae 70g, and Folium Artemisiae Argyi 70g, is conventionally prepared into granule.
Embodiment 35:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 20g, Radix Salviae Miltiorrhizae 15g, Rhizoma Chuanxiong 15g, lavandula angustifolia 15g, Herba Menthae 10g, and Folium Artemisiae Argyi 10g, is conventionally prepared into granule.
Embodiment 36:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 80g, Radix Salviae Miltiorrhizae 60g, Rhizoma Chuanxiong 60g, lavandula angustifolia 60g, Herba Menthae 50g, and Folium Artemisiae Argyi 50g, is conventionally prepared into granule.
Embodiment 37:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 30g, Radix Salviae Miltiorrhizae 20g, Rhizoma Chuanxiong 20g, lavandula angustifolia 20g, Herba Menthae 15g, and Folium Artemisiae Argyi 15g, is conventionally prepared into powder.
Embodiment 38:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 60g, Radix Salviae Miltiorrhizae 50g, Rhizoma Chuanxiong 50g, lavandula angustifolia 50g, Herba Menthae 40g, and Folium Artemisiae Argyi 40g, is conventionally prepared into powder.
Embodiment 39:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 12g, Radix Salviae Miltiorrhizae 10g, Rhizoma Chuanxiong 10g, lavandula angustifolia 10g, Herba Menthae 5g, and Folium Artemisiae Argyi 5g, is conventionally prepared into effervescent.
Embodiment 40:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 20g, Radix Salviae Miltiorrhizae 15g, Rhizoma Chuanxiong 15g, lavandula angustifolia 15g, Herba Menthae 10g, and Folium Artemisiae Argyi 10g, is conventionally prepared into effervescent.
Embodiment 41:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis extract 6g, Radix Salviae Miltiorrhizae extract 5g, Rhizoma Chuanxiong extract 5g, Herba Lysimachiae foenum-graeci extract 5g, Folium Menthae extract 3g, Folium Artemisiae Argyi extract 3g, is conventionally prepared into effervescent.
Embodiment 42:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis extract 120g, Radix Salviae Miltiorrhizae extract 100g, Rhizoma Chuanxiong extract 100g, Herba Lysimachiae foenum-graeci extract 100g, Folium Menthae extract 80g, Folium Artemisiae Argyi extract 80g, is conventionally prepared into tablet.
Embodiment 43:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis water extract 10g, Danshen 8g, Rhizoma Chuanxiong 8g, lavender liquid extract 8g, aqua methnae extract 5g, Folium Artemisiae Argyi water extract 5g, is conventionally prepared into tablet.
Embodiment 44:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis water extract 100g, Danshen 80g, Rhizoma Chuanxiong water extract 80g, lavender liquid extract 80g, aqua methnae extract 70g, Folium Artemisiae Argyi water extract 70g, is conventionally prepared into tablet.
Embodiment 45:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis water extract 20g, Danshen 15g, Rhizoma Chuanxiong water extract 15g, lavender liquid extract 15g, aqua methnae extract 10g, Folium Artemisiae Argyi water extract 10g, is conventionally prepared into tablet.
Embodiment 46:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis ethanol extraction 80g, Radix Salviae Miltiorrhizae ethanol extraction 60g, Rhizoma Chuanxiong ethanol extraction 60g, lavandula angustifolia ethanol extraction 60g, Herba Menthae ethanol extraction 50g, Folium Artemisiae Argyi ethanol extraction 50g, is conventionally prepared into tablet.
Embodiment 47:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis ethanol extraction 30g, Radix Salviae Miltiorrhizae ethanol extraction 20g, Rhizoma Chuanxiong ethanol extraction 20g, lavandula angustifolia ethanol extraction 20g, Herba Menthae ethanol extraction 15g, Folium Artemisiae Argyi ethanol extraction 15g, is conventionally prepared into unguentum.
Embodiment 48:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis methanolic extract 60g, Radix Salviae Miltiorrhizae methanolic extract 50g, Rhizoma Chuanxiong methanolic extract 50g, lavandula angustifolia methanolic extract 50g, Herba Menthae methanolic extract 40g, Folium Artemisiae Argyi methanolic extract 40g, is conventionally prepared into unguentum.
Embodiment 49:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis methanolic extract 12g, Radix Salviae Miltiorrhizae methanolic extract 10g, Rhizoma Chuanxiong methanolic extract 10g, lavandula angustifolia methanolic extract 10g, Herba Menthae methanolic extract 5g, Folium Artemisiae Argyi methanolic extract 5g, is conventionally prepared into unguentum.
Embodiment 50:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis n-butanol extract 20g, Radix Salviae Miltiorrhizae n-butanol extract 15g, Rhizoma Chuanxiong n-butanol extract 15g, lavandula angustifolia n-butanol extract 15g, Herba Menthae n-butanol extract 10g, Folium Artemisiae Argyi n-butanol extract 10g, is conventionally prepared into unguentum.
The pharmaceutical composition of above-mentioned any embodiment, can adopt the mode of bathing or foot bath.Concrete grammar is: water aforementioned pharmaceutical compositions directly being put into 90 ~ 100 DEG C soaks, and soaks 20 ~ 30 minutes when coolant-temperature gage is cooled to 35 ~ 43 DEG C.
Embodiment 51:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 6g, Radix Salviae Miltiorrhizae 5g, Rhizoma Chuanxiong 5g, lavandula angustifolia 5g, Herba Menthae 3g, Folium Artemisiae Argyi 3g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 52:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 120g, Radix Salviae Miltiorrhizae 100g, Rhizoma Chuanxiong 100g, lavandula angustifolia 100g, Herba Menthae 80g, Folium Artemisiae Argyi 80g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 53:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 10g, Radix Salviae Miltiorrhizae 8g, Rhizoma Chuanxiong 8g, lavandula angustifolia 8g, Herba Menthae 5g, Folium Artemisiae Argyi 5g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 54:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 100g, Radix Salviae Miltiorrhizae 80g, Rhizoma Chuanxiong 80g, lavandula angustifolia 80g, Herba Menthae 70g, Folium Artemisiae Argyi 70g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 55:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 20g, Radix Salviae Miltiorrhizae 15g, Rhizoma Chuanxiong 15g, lavandula angustifolia 15g, Herba Menthae 10g, Folium Artemisiae Argyi 10g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 56:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 80g, Radix Salviae Miltiorrhizae 60g, Rhizoma Chuanxiong 60g, lavandula angustifolia 60g, Herba Menthae 50g, Folium Artemisiae Argyi 50g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 57:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 30g, Radix Salviae Miltiorrhizae 20g, Rhizoma Chuanxiong 20g, lavandula angustifolia 20g, Herba Menthae 15g, Folium Artemisiae Argyi 15g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 58:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 60g, Radix Salviae Miltiorrhizae 50g, Rhizoma Chuanxiong 50g, lavandula angustifolia 50g, Herba Menthae 40g, Folium Artemisiae Argyi 40g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 59:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 12g, Radix Salviae Miltiorrhizae 10g, Rhizoma Chuanxiong 10g, lavandula angustifolia 10g, Herba Menthae 5g, Folium Artemisiae Argyi 5g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 60:
A bathing preparation for treatment of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 20g, Radix Salviae Miltiorrhizae 15g, Rhizoma Chuanxiong 15g, lavandula angustifolia 15g, Herba Menthae 10g, Folium Artemisiae Argyi 10g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 61:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 6g, Radix Salviae Miltiorrhizae 5g, Rhizoma Chuanxiong 5g, lavandula angustifolia 5g, Herba Menthae 3g, Folium Artemisiae Argyi 3g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 62:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 120g, Radix Salviae Miltiorrhizae 100g, Rhizoma Chuanxiong 100g, lavandula angustifolia 100g, Herba Menthae 80g, Folium Artemisiae Argyi 80g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 63:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 10g, Radix Salviae Miltiorrhizae 8g, Rhizoma Chuanxiong 8g, lavandula angustifolia 8g, Herba Menthae 5g, Folium Artemisiae Argyi 5g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 64:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 100g, Radix Salviae Miltiorrhizae 80g, Rhizoma Chuanxiong 80g, lavandula angustifolia 80g, Herba Menthae 70g, Folium Artemisiae Argyi 70g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 65:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 20g, Radix Salviae Miltiorrhizae 15g, Rhizoma Chuanxiong 15g, lavandula angustifolia 15g, Herba Menthae 10g, Folium Artemisiae Argyi 10g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 66:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 80g, Radix Salviae Miltiorrhizae 60g, Rhizoma Chuanxiong 60g, lavandula angustifolia 60g, Herba Menthae 50g, Folium Artemisiae Argyi 50g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 67:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 30g, Radix Salviae Miltiorrhizae 20g, Rhizoma Chuanxiong 20g, lavandula angustifolia 20g, Herba Menthae 15g, Folium Artemisiae Argyi 15g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 68:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 60g, Radix Salviae Miltiorrhizae 50g, Rhizoma Chuanxiong 50g, lavandula angustifolia 50g, Herba Menthae 40g, Folium Artemisiae Argyi 40g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 69:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 12g, Radix Salviae Miltiorrhizae 10g, Rhizoma Chuanxiong 10g, lavandula angustifolia 10g, Herba Menthae 5g, Folium Artemisiae Argyi 5g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 70:
A kind of bathing preparation for the treatment of of insomnia patients, it is made up of the raw material of following weight ratio: Plumula Nelumbinis 20g, Radix Salviae Miltiorrhizae 15g, Rhizoma Chuanxiong 15g, lavandula angustifolia 15g, Herba Menthae 10g, Folium Artemisiae Argyi 10g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Pharmaceutical composition of the present invention can adopt oral administration, and foot bath also can be adopted to soak, and stifling, bathing also can be adopted to invade bubble, all can reach effective prevention and therapy effect.In order to strengthen therapeutic effect further, after pharmaceutical composition of the present invention can being carried out constituents extraction, carry out combination and compatibility.Pharmaceutical composition of the present invention has the effect of anti-inflammatory analgesic, clinically can adopt demibain mode drug treatment bacterial vaginitis and anal inflammation.
Beneficial effect of the present invention is verified below by concrete experimentation:
1. the experimentation of medicine sedative-hypnotic effect of the present invention
1.1 test material
Select healthy adult SD male rat 50, body weight 200 ± 20g, purchased from Chengdu University of Traditional Chinese Medicine's animal experimental center, the quality certification number: scxk (river) 2008-11.Weighed by animal before test, numbering, is divided into blank group, model group, medicine high dose group of the present invention, dosage group and medicine low dose group of the present invention in medicine of the present invention at random, five groups altogether, often organizes 10.Take Plumula Nelumbinis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, lavandula angustifolia, Herba Menthae and Folium Artemisiae Argyi according to weight ratio, be specially Plumula Nelumbinis 120g, Radix Salviae Miltiorrhizae 100g, Rhizoma Chuanxiong 100g, lavandula angustifolia 100g, Herba Menthae 50g, Folium Artemisiae Argyi 50g, medical material is purchased from Chengdu, Sichuan Province lotus pond Chinese Medicinal Materials Markets.
1.2 experimental technique
The soak by water 1-1.5 hour that weight is 5-6 times amount is added by after medical material Plumula Nelumbinis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, lavandula angustifolia, Herba Menthae and Folium Artemisiae Argyi mixing, decoct 2 times, merge decocting liquid, the medicinal liquid of 1g/ml after concentrated, to get 200ml concentration of liquid medicine be 2g/ml is high dose group, get the dilution of 50ml medicinal liquid for 100ml medicinal liquid, be configured to the medicinal liquid of 0.5g/ml.Each group all by 2ml equal-volume gastric infusion, every day 1 time, successive administration 7 days.Adopt fenclonine to set up animal model, model group, high, medium and low dosage group give disposable celiac injection fenclonine (PCAP) 30Omg/kg, the blank group of normal saline giving same dosage.The change of the rat spontaneous activity of each group and brain rapheal nuclei neurotransmitter during observing medication.
60min and 90min after last administration, observe rat spontaneous activity, then the rat extracting blood that breaks end is centrifugal, and under ice bath, isolate rapidly brain stem weigh, put in glass homogenizer, add 2% solution of trichloroacetic acid (being chilled to 4e in advance) 500pL, gentle homogenate, homogenate suction pipe is carefully transferred in centrifuge tube, uses 200uLNaHZPO
4(0.33mol/L, pH6.O include 0.5mol/LNa to solution
2eDTA) swing and wash homogenizer, washing liquid is incorporated to centrifuge tube, is mixed evenly, and low-temperature and high-speed is centrifugal, gets supernatant 50uL sample introduction and measures.
1.3 result
After adopting fenclonine (PCAP) modeling, the increase more obvious than normal rats of activity time in 2min, and the number of times that in 2min, forelimb act is vertical also obviously increases, after giving medicine 60min respectively, high, medium and low dosage group rat activity time and forelimb in 2min lift vertical all obvious than the model group minimizing of number of times.After difference administration 90min, model group rats is still in active state, and high, middle dosage group rat activity time and forelimb in 2min are lifted vertical number of times and all obviously reduced.The results are shown in Table 1.
The each spontaneous activity change organizing rat of table 1 is compared (
n=10)
Note: compare * p<0.05 with blank group, * * p<0.01; △ p<0.05 is compared, △ △ p<0.01 with model group.
Model group is comparing with blank, and in rat cerebral tissue, 5-HT, DA, NE, E content all significantly declines, and after the Drug therapy of variable concentrations, all has restitution in various degree.The results are shown in Table 2.
The change of table 2 each group rat brain rapheal nuclei neurotransmitter is compared (
n=10)
Note: compare * p<0.05 with blank group, * * p<0.01; △ p<0.05 is compared, △ △ p<0.01 with model group.
Above-mentioned experimental result shows, pharmaceutical composition of the present invention has good sedative-hypnotic effect.
Shown by clinical research, to the total effective rate of insomniac be 85.29% (insomniac 68 example, clinic control 42 example during pharmaceutical formulation of the present invention, effective 16 examples, invalid 10 examples, total effective rate is 85.29%), medicine of the present invention has blood circulation promoting and blood stasis dispelling, effect of promoting the circulation of QI to relieve pain simultaneously.Show that of the present invention pharmaceutical composition xylol causes mice auricle swelling, Ovum Gallus domesticus album causes rat paw edema all has inhibitory action by pharmacodynamic study, show that pharmaceutical composition of the present invention has the effect of antiinflammatory.
Claims (10)
1. a bathing preparation for treatment of insomnia patients, is characterized in that: it is made up of the raw material of following ratio of weight and number: Plumula Nelumbinis 6 ~ 120 parts, Radix Salviae Miltiorrhizae 5 ~ 100 parts, Rhizoma Chuanxiong 5 ~ 100 parts, lavandula angustifolia 5 ~ 100 parts, Herba Menthae 3 ~ 80 parts, Folium Artemisiae Argyi 3 ~ 80 parts.
2. the bathing preparation of a kind for the treatment of of insomnia patients according to claim 1, is characterized in that: the ratio of weight and number of described each raw material is: Plumula Nelumbinis 10 ~ 100 parts, Radix Salviae Miltiorrhizae 8 ~ 80 parts, Rhizoma Chuanxiong 8 ~ 80 parts, lavandula angustifolia 8 ~ 80 parts, Herba Menthae 5 ~ 70 parts, Folium Artemisiae Argyi 5 ~ 70 parts.
3. the bathing preparation of a kind for the treatment of of insomnia patients according to claim 1, is characterized in that: the ratio of weight and number of described each raw material is: Plumula Nelumbinis 20 ~ 80 parts, Radix Salviae Miltiorrhizae 15 ~ 60 parts, Rhizoma Chuanxiong 15 ~ 60 parts, lavandula angustifolia 15 ~ 60 parts, Herba Menthae 10 ~ 50 parts, Folium Artemisiae Argyi 10 ~ 50 parts.
4. the bathing preparation of a kind for the treatment of of insomnia patients according to claim 1, is characterized in that: the ratio of weight and number of described each raw material is: Plumula Nelumbinis 30 ~ 60 parts, Radix Salviae Miltiorrhizae 20 ~ 50 parts, Rhizoma Chuanxiong 20 ~ 50 parts, lavandula angustifolia 20 ~ 50 parts, Herba Menthae 15 ~ 40 parts, Folium Artemisiae Argyi 15 ~ 40 parts.
5. the bathing preparation of a kind for the treatment of of insomnia patients according to claim 1, is characterized in that: the ratio of weight and number of described each raw material is: Plumula Nelumbinis 12 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Chuanxiong 10 parts, lavandula angustifolia 10 parts, Herba Menthae 5 parts, Folium Artemisiae Argyi 5 parts.
6. the bathing preparation of a kind for the treatment of of insomnia patients according to claim 1, is characterized in that: the ratio of weight and number of described each raw material is: Plumula Nelumbinis 20 parts, Radix Salviae Miltiorrhizae 15 parts, Rhizoma Chuanxiong 15 parts, lavandula angustifolia 15 parts, Herba Menthae 10 parts, Folium Artemisiae Argyi 10 parts.
7. the bathing preparation of a kind for the treatment of of insomnia patients according to claim 1, it is characterized in that: the ratio of weight and number of described each raw material is: Plumula Nelumbinis extract 6 ~ 120 parts, Radix Salviae Miltiorrhizae extract 5 ~ 100 parts, Rhizoma Chuanxiong extract 5 ~ 100 parts, Herba Lysimachiae foenum-graeci extract 5 ~ 100 parts, Folium Menthae extract 3 ~ 80 parts, Folium Artemisiae Argyi extract 3 ~ 80 parts.
8. the bathing preparation of a kind for the treatment of of insomnia patients according to claim 7, is characterized in that: the ratio of weight and number of described each raw material is: Plumula Nelumbinis extract 12 parts, Radix Salviae Miltiorrhizae extract 10 parts, Rhizoma Chuanxiong extract 10 parts, Herba Lysimachiae foenum-graeci extract 10 parts, Folium Menthae extract 5 parts, Folium Artemisiae Argyi extract 5 parts.
9. prepare a method for the bathing preparation in claim 1 ~ 8 described in any one claim, it is characterized in that: the method comprises the steps:
S1: take Plumula Nelumbinis by weight, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, lavandula angustifolia, Herba Menthae and Folium Artemisiae Argyi;
S2: conveniently preparation method is prepared into bathing preparation.
10. a kind of method preparing bathing preparation according to claim 9, is characterized in that: described bathing preparation is powder, granule, lotion, powder, decoction, unguentum, effervescent.
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| CN114146126A (en) * | 2021-12-20 | 2022-03-08 | 深圳市岐之源健康生物科技有限公司 | Traditional Chinese medicine composition for improving sleep quality and preparation method thereof |
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| CN203262844U (en) * | 2013-05-21 | 2013-11-06 | 阳静波 | Cervical vertebra self-traction pillow suit |
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| CN114146126A (en) * | 2021-12-20 | 2022-03-08 | 深圳市岐之源健康生物科技有限公司 | Traditional Chinese medicine composition for improving sleep quality and preparation method thereof |
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