CN102671178B - Preparation method of Chinese medicinal composition for treating nephrotic syndrome and uremia and application thereof - Google Patents
Preparation method of Chinese medicinal composition for treating nephrotic syndrome and uremia and application thereof Download PDFInfo
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Abstract
The invention belongs to the field of medicine, and relates to a Chinese medicinal composition and a preparation method thereof, in particular to a Chinese medicinal composition for treating a nephrotic syndrome and uremia and a preparation method and application thereof. The Chinese medicinal composition is prepared by processing Chinese medicinal raw materials including dangshen, dried body of ground beetle, astragalus, large-head atractylodes rhizome, szechuan lovage rhizome, white paeony root, chicken gizzard membrane, Chinese yam, common fennel, prepared rehmannia rhizome, cornus, indian buead, cortex eucommiae, barbary wolfberry fruit, fructus psoraleae, cynomorium coccineum, grassleaf sweetflag, turmeric root-tuber, dried orange peel, pinellia tuber, common coltsfoot flower, dwarf lilyturf root, unibract fritillary bulb, morning glory, desertliving cistanche, liquoric root, rangooncreeper fruit, oriental waterplantain rhizome and Chinese angelica.
Description
Technical field
The invention belongs to field of medicaments, relate to a kind of Chinese medicine composition and preparation method thereof, be specifically related to a kind of Chinese medicine composition for the treatment of the nephrotic syndrome and preparation method thereof.
Background technology
Nephropathy, the various diseases of kidney.Between viscera, all keep dynamic equilibrium between interior environment and external environment.If the multiple paathogenic factor in the interior external world has been destroyed the balance of human body, cause internal organs QI and blood functional disorder, sick reaching in kidney causes that kidney disease produces.The morbidity prerequisite, with human righteousness's power, and evil quadrature is striven and both sides' prosperity and decline situation.Nephropathy high-end technology exchanging meeting in 2011, the cell exchange regeneration therapy whole case is passed through, and solves a nephropathy difficult problem.Cause the cause of disease of kidney disease varied, the internal and external factors such as six climate exopathogens, seven emotions, diet, work and rest, exhaustion due to sexual indulgence, poison of drug, unexpected injury all can cause a disease.And at disease generation, evolution process, the cause of disease and pathological product often interact, reciprocal causation.Certain one-phase pathological product also can become another stage paathogenic factor, and causes advancing of disease.
Various age groups can occur in nephropathy, and the traditional Chinese medical science thinks, nephropathy is mainly because organism metabolic disorder, negative and positive of qi and blood imbalance, function is unbalance, add that people's diet does not save, incoordination of seven emotions, work be immoderate, thereby cause the day by day occurred frequently of the nephrotic syndrome.
For this reason, the inventor is through a kind of Chinese medicine composition for the treatment of nephropathy has been invented in research and continuous practice for a long time.
Summary of the invention
Purpose of the present invention just is to provide a kind of Chinese medicine composition for the treatment of nephropathy.
Pharmaceutical composition of the present invention is processed into by raw material of Chinese medicine Radix Codonopsis, eupolyphaga, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Endothelium Corneum Gigeriae Galli, Rhizoma Dioscoreae, Fructus Foeniculi, Radix Rehmanniae Preparata, taro meat (Fructus Corni), Poria, the Cortex Eucommiae, Fructus Lycii, Fructus Psoraleae, Herba Cynomorii, Rhizoma Acori Graminei, Radix Curcumae, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Flos Farfarae, Radix Ophiopogonis, Bulbus Fritillariae Uninbracteatae, Semen Pharbitidis (morning glory), Herba Cistanches, Radix Glycyrrhizae, Fructus Quisqualis, Rhizoma Alismatis (Rhizoma Alismatis) and Radix Angelicae Sinensis.
Concrete, Chinese medicine composition of the present invention is processed into by following raw material of Chinese medicine:
Radix Codonopsis 12-105 gram, eupolyphaga 4-39 gram, Radix Astragali 17-150 gram, Rhizoma Atractylodis Macrocephalae 4-36 gram,
Rhizoma Chuanxiong 3-27 gram, Radix Paeoniae Alba 17-150 gram, Endothelium Corneum Gigeriae Galli 4-39 gram, Rhizoma Dioscoreae 17-150 gram, Fructus Foeniculi 17-150 gram, Radix Rehmanniae Preparata 33-300 gram, Fructus Corni 17-150 gram,
Poria 9-78 gram, Cortex Eucommiae 3-30 gram, Fructus Lycii 5-45 gram, Fructus Psoraleae 5-45 gram, Herba Cynomorii 5-45 gram, Rhizoma Acori Graminei 5-45 gram, Radix Curcumae 5-45 gram, Pericarpium Citri Reticulatae 5-45 gram,
Rhizoma Pinelliae 5-45 gram, Flos Farfarae 5-45 gram, Radix Ophiopogonis 5-45 gram, Bulbus Fritillariae Uninbracteatae 5-45 gram,
Morning glory 5-45 gram, Herba Cistanches 5-45 gram, Radix Glycyrrhizae 5-45 gram, Fructus Quisqualis 3-27 gram,
Rhizoma Alismatis 17-150 gram, Radix Angelicae Sinensis 3-27 gram.
Preferably, Chinese medicine composition of the present invention is processed into by following raw material of Chinese medicine:
Radix Codonopsis 17.5-70 gram, eupolyphaga 6.5-26 gram, Radix Astragali 25-100 gram, Rhizoma Atractylodis Macrocephalae 6-24 gram,
Rhizoma Chuanxiong 4.5-18 gram, Radix Paeoniae Alba 25-100 gram, Endothelium Corneum Gigeriae Galli 6.5-26 gram, Rhizoma Dioscoreae 25-100 gram, Fructus Foeniculi 25-100 gram, Radix Rehmanniae Preparata 50-200 gram, Fructus Corni 25-100 gram, Poria 13-52 gram, Cortex Eucommiae 5-20 gram, Fructus Lycii 7.5-30 gram, Fructus Psoraleae 7.5-30 gram, Herba Cynomorii 7.5-30 gram, Rhizoma Acori Graminei 7.5-30 gram, Radix Curcumae 7.5-30 gram, Pericarpium Citri Reticulatae 7.5-30 gram, Rhizoma Pinelliae 7.5-30 gram, Flos Farfarae 7.5-30 gram, Radix Ophiopogonis the 7.5-30 gram, Bulbus Fritillariae Uninbracteatae 7.5-30 gram, morning glory 7.5-30 gram, Herba Cistanches 7.5-30 gram, Radix Glycyrrhizae 7.5-30 gram, Fructus Quisqualis 3-18 gram, Rhizoma Alismatis 25-100 gram, Radix Angelicae Sinensis 4.5-18 gram.
Further preferred, Chinese medicine composition of the present invention is processed into by following raw material of Chinese medicine:
Radix Codonopsis 20-50 gram, eupolyphaga 10-20 gram, Radix Astragali 30-70 gram, Rhizoma Atractylodis Macrocephalae 10-20 gram,
Rhizoma Chuanxiong 5-15 gram, Radix Paeoniae Alba 30-70 gram, Endothelium Corneum Gigeriae Galli 10-15 gram, Rhizoma Dioscoreae 30-70 gram,
Fructus Foeniculi 30-70 gram, Radix Rehmanniae Preparata 80-120 gram, Fructus Corni 30-70 gram, Poria 20-30 gram, Cortex Eucommiae 5-15 gram, Fructus Lycii 10-20 gram, Fructus Psoraleae 10-20 gram, Herba Cynomorii 10-20 gram, Rhizoma Acori Graminei 10-20 gram, Radix Curcumae 10-20 gram, Pericarpium Citri Reticulatae 10-20 gram, Rhizoma Pinelliae 10-20 gram, Flos Farfarae 10-20 gram, Radix Ophiopogonis 10-20 gram, Bulbus Fritillariae Uninbracteatae 10-20 gram, morning glory 10-20 gram,
Herba Cistanches 10-20 gram, Radix Glycyrrhizae 10-20 gram, Fructus Quisqualis 6-12 gram, Rhizoma Alismatis 30-70 gram, Radix Angelicae Sinensis 6-12 gram.
Raw material of Chinese medicine of the present invention can be in market or pharmacy buy, belong to existing product.
Radix Codonopsis: have invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, the interior-heat effect of quenching one's thirst.
Eupolyphaga: the another name eupolyphoge sinensis is Blattaria, the female adult worm of Corydiidae insecticide.Has removing blood stasis with potent drugs blood, the reuniting the fractured tendons and bones effect.
The Radix Astragali: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.
The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.
Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.
The Radix Paeoniae Alba: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.
Endothelium Corneum Gigeriae Galli: removing food stagnancy is stagnant, strengthening the spleen and stomach.Control the food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition is quenched one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.
Rhizoma Dioscoreae: spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Be used for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.
Fructus Foeniculi: dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach.
Radix Rehmanniae Preparata: Radix Rehmanniae Preparata is that (formal name used at school: tuber Rehmannia glutinosa) has another name called Radix Rehmanniae Preparata or throws oneself on the ground scrophulariaceae rehmannia glutinosa plant.Nourishing YIN and supplementing blood, beneficial essence is filled out marrow.
Fructus Corni: Fructus Corni is the fruit of Cornaceae plant Fructus Corni.The function nourishing the liver and kidney, the astringing YIN to stop sweating emergency treatment of collapse is the nourishing kidney yin key medicine.
Poria: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.
The Cortex Eucommiae: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.
Fructus Lycii: nourishing the liver and kidney, replenishing vital essence to improve eyesight.
Fructus Psoraleae: Fructus Psoraleae is the fruit of legumes psoraleae, is the another name of Fructus Psoraleae.Reinforcing the kidney and supporting YANG; Helping inspiration to relieve asthma; Warming spleen and stopping diarrha.Main insufficiency of kidney-YANG; Below element deficiency and cold; Chills and pain of the waist and kness; Impotence and seminal emission; Frequent micturition; The enuresis; Failure of the kidney in receiving QI; Dyspnea due to deficiency is more than; Asthenia of both the spleen and kidney; The stool chronic diarrhea; Vitiligo; Speckle is bald; Psoriasis.
Herba Cynomorii: kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.
Rhizoma Acori Graminei: can dirtyly have one's ideas straightened out for warding off, a surname's gas is by expectorant, detoxifcation, parasite killing.
Radix Curcumae: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.
Pericarpium Citri Reticulatae: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
The Rhizoma Pinelliae: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.
Flos Farfarae: be the another name of coltsfoot, be the alabastrum of Compositae coltsfoot.Has nourishing the lung to keep the adverse QI downward, the effect of the antitussive that reduces phlegm.
Radix Ophiopogonis: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.
Bulbus Fritillariae Uninbracteatae: Bulbus Fritillariae Uninbracteatae is herbaceos perennial, and its bulb hyoscine has the merit of relieving cough and resolving phlegm, heat clearing away eliminating stagnation.
Semen Pharbitidis: be the another name of Semen Pharbitidis, the removing water retention by purgation relieving constipation, drink is washed in expectorant, and parasite killing is attacked long-pending.
Herba Cistanches: kidney invigorating and YANG supporting, intestine moistening, hemostasis.
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Fructus Quisqualis: killing insect and eliminating accumulation.
Rhizoma Alismatis: diuresis, clearing away damp-heat.
Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Single medicinal material in above composition, especially ministerial drug and adjuvant drug also can be replaced by the suitable Chinese medicine with identical property of medicine, and its drug effect of the Chinese medicine preparation after replacement is constant.
In above composition the of the present invention, the weight of each medicine of distinguishing the flavor of is calculated with crude drug, if in grams, above-mentioned formula forms the pharmaceutical preparation that can be made into a dosage schedule, if day takes 2-4 time, is the dose of 40-60 days, as make preparation, can be made into the 100-1000 agent because of varying in size of preparation.Described 100-1000 agent refers to the dosage form of unit dose, as tablet 100-1000 sheet, and capsule 100-1000 grain, granule 100-1000g, oral liquid 100-1000ml, unguentum 100-1000g, pill 10-1000 ball etc.
Above composition is by weight as proportioning, can increase or reduce according to corresponding proportion when producing, can be take kg as unit as large-scale production, or take t (ton) as unit; Preparation also can be take g as unit on a small scale.Weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount that can corresponding adjustment forms increases or reduces being no more than 100%, and drug effect is substantially constant.
Chinese medicine preparation of the present invention is to process through extraction or other modes by the raw material of Chinese medicine that above-mentioned formula is formed, and makes pharmaceutically active substance, subsequently, take this material as raw material, add the medicine acceptable carrier when needing, make according to the routine techniques of galenic pharmacy.Described active substance can obtain by extracting respectively raw material of Chinese medicine, also can obtain by common extraction raw material of Chinese medicine, also can obtain by other means, as: by pulverize, squeeze, calcine, grind, sieve, percolation, extraction, water extraction, alcohol extraction, ester are carried, the methods such as ketone is carried, chromatography obtain, these active substances can be the material of extractum form, can be that dry extract can be also fluid extract, make different concentration according to the different needs decisions of preparation.
Pharmaceutically active substance in Chinese medicine preparation of the present invention, its shared percentage by weight in preparation can be 0.1-99.9%, all the other are the medicine acceptable carrier.Pharmaceutical preparation of the present invention exists with unit dosage form, and described unit dosage form refers to the unit of preparation, as every of tablet, and every capsules of capsule, every bottle of oral liquid, every bag of granule etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, peroral dosage form preferably, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum etc.
Chinese medicine preparation of the present invention, the preparation of its oral administration can contain excipient commonly used, such as binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and wetting agent, can carry out coating to tablet in case of necessity.
Applicable filler comprises cellulose, mannitol, lactose and other similar filler.Suitable disintegrating agent comprises starch, polyvinylpyrrolidone and starch derivatives, for example sodium starch glycollate.Suitable lubricant comprises, for example magnesium stearate.The acceptable wetting agent of suitable medicine comprises sodium lauryl sulphate.
Can fill by mixing, the method that tabletting etc. are commonly used prepares solid oral composition.Repeatedly mix active substance is distributed in those compositionss of a large amount of filleies of whole use.
The form of oral liquid can be for example aqueous or oily suspensions, solution, Emulsion, syrup or elixir, can be perhaps a kind of available water before use or the composite dry products of other suitable carrier.This liquid preparation can contain conventional additive, such as suspending agent, for example sorbitol, syrup, methylcellulose, gelatin, hydroxyethyl-cellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenation edible fat, emulsifying agent, for example lecithin, anhydro sorbitol monooleate or arabic gum; Non-aqueous carrier (they can comprise edible oil), for example almond oil, fractionated coconut oil, such as oily ester, propylene glycol or the ethanol of the ester of glycerol; Antiseptic, for example para hydroxybenzene methyl ester or propyl p-hydroxybenzoate or sorbic acid, and if need, can contain conventional flavouring agent or coloring agent.
For injection, the liquid unit dosage forms of preparation contains active substance of the present invention and sterile carrier.According to carrier and concentration, this compound can be suspended or dissolving.Normally by active substance being dissolved in a kind of carrier, then filter-sterilized before it is packed into a kind of suitable bottle or ampoule seals in the preparation of solution.Adjuvant for example a kind of local anesthetic, antiseptic and buffer agent also can be dissolved in this carrier.In order to improve its stability, can be after the bottle of packing into, that this compositions is freezing, and under vacuum, water is removed.
Chinese medicine preparation of the present invention, optionally add suitable medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier is selected from: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, EDETATE SODIUM, EDTA calcium sodium, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, the phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Preparation of the present invention is determined usage and dosage according to patient's situation in use, but takes every day three times, each 30-90 agent, as: the 30-90 ball.
Another object of the present invention is to provide preparation method of the present invention.
Chinese medicine composition of the present invention, its pharmaceutically active substance makes through extracting processing, can process with following methods:
Get the medicine process decocting in water in formula, obtain water extract, be condensed into cream, take this clear paste as raw material, add the medicine acceptable carrier when needing, make according to the routine techniques of galenic pharmacy.
Perhaps
Get Chinese herb and pulverize and sieve, mixing is used water pill, and drying is granulated, and be get final product.
Further object of the present invention is to provide Chinese medicine composition of the present invention to treat and/or prevent application in the medicine of nephropathy in preparation.
But active substance Immunosuppression complex formation in medicine of the present invention; suppress the Fibrotic formation of glomerule; strengthening spleen, tonifying kidney medicine such as Rhizoma Atractylodis Macrocephalae Rhizoma Dioscoreae etc. can enhancing body be resisted microbiological attack; epithelial tissue reparation to pathological changes has remarkable effect; the kidney vascular smooth muscles that can relax such as movable blood soft hard medicine; vasospasm is removed in the treatment by Chinese herbs of the nephrotic syndrome, improves blood flow, thereby reaches the purpose of renal function protecting.
The specific embodiment
By following examples, the present invention is made further explanation and explanation, but be not used for limiting the scope of the invention.
Embodiment 1, pill of the present invention preparation
Radix Codonopsis 35 grams, eupolyphaga 13 grams, the Radix Astragali 50 grams, the Rhizoma Atractylodis Macrocephalae 12 grams,
Rhizoma Chuanxiong 9 grams, the Radix Paeoniae Alba 50 grams, Endothelium Corneum Gigeriae Galli 13 grams, Rhizoma Dioscoreae 50 grams,
Fructus Foeniculi 50 grams, Radix Rehmanniae Preparata 100 grams, Fructus Corni 50 grams, Poria 26 grams,
The Cortex Eucommiae 10 grams, Fructus Lycii 15 grams, Fructus Psoraleae 15 grams, Herba Cynomorii 15 grams,
Rhizoma Acori Graminei 15 grams, Radix Curcumae 15 grams, Pericarpium Citri Reticulatae 15 grams, the Rhizoma Pinelliae 15 grams,
Flos Farfarae 15 grams, Radix Ophiopogonis 15 gram, Bulbus Fritillariae Uninbracteatae 15 grams, morning glory 15 grams,
Herba Cistanches 15 grams, Radix Glycyrrhizae 15 grams, Fructus Quisqualis 9 grams, Rhizoma Alismatis 50 grams,
Radix Angelicae Sinensis 9 grams.
Get above-mentioned Chinese herb and pulverize and sieve, mixing is used water pill, and drying is granulated, and be get final product.
Preparation gained pill is 45 days dosages.
Embodiment 2, curative effect of the present invention
Investigate the effect of Chinese medicine composition of the present invention by clinical trial
Experimental subject:
Choose 200 routine nephrotics, age 20-70 year, the course of disease 1-10 year.
Patient's inclusive criteria:
(1) a large amount of urine protein, urine protein 〉=3.5g/d; (2) hypoproteinemia, plasma albumin≤30g/L; (3) edema; (4) hyperlipemia.Wherein, (1) (2) two is the diagnosis essential condition.
Patient's dosage:
The medicine of oral example 1, every day 3 times, each 60, be 18 months the course for the treatment of.
Criterion of therapeutical effect:
Effectively: refer to that the state of an illness returns to one's perfect health, symptom, sign disappear, and the routine urinalysis check continues for 3 times normal, and it is normal that urine protein quantitation, blood fat, plasma protein, serum immune globulin, hemorheology index all recover.
Produce effects: refer to that sb.'s illness took a favorable turn more than 85%, symptom, sign disappear, and urine protein is qualitative, and the 24h urine protein quantitation is treated front minimizing more than 1/2, and blood fat obviously improves, and serum immune globulin, hemorheology index approach or recover normal.
Invalid: symptom and sign and medical inspection are all without obviously improving.
Experimental result:
After the patient took medicine 18 months, curative effect was as follows:
| Patient's sum | Effectively (number) | Produce effects (number) | Invalid (number) | Total effective rate (%) |
| 200 people | 120 | 70 | 10 | 95% |
The experimental result demonstration, the patient has no adverse reaction taking medicine of the present invention after 18 months, and most of patient's disease is all taken a turn for the better, and total effective rate is up to 95%.
Embodiment 3,
Lee, the female, 50 years old, the patient was diagnosed as nephrotic syndrome in August, 2010, clinically was characterized by two lower limbs edema, waist is aching and tired, limbs fatigue, pale tongue is fat, paruria.The patient takes medicine of the present invention from November, 2010, after taking medicine 12 months, symptom disappears substantially, after go the examination in hospital indices substantially up to standard.
Embodiment 4,
Liu, the man, 65 years old, the lower limb Mild edema appearred in the patient in October, 2009, and is tired unable, tired weak, frequent urination at night, moist and slippery fur, pale tongue is diagnosed as nephritis-edema to hospital afterwards.Take medicine of the present invention after 10 months, patient's edema alleviates, and soreness of waist sx↓, extremity check that without weak indices is substantially up to standard, reach clinical recovery.
Embodiment 5, tablet
Radix Codonopsis 20 grams, eupolyphaga 10 grams, the Radix Astragali 30 grams, the Rhizoma Atractylodis Macrocephalae 10 grams,
Rhizoma Chuanxiong 5 grams, the Radix Paeoniae Alba 30 grams, Endothelium Corneum Gigeriae Galli 10 grams, Rhizoma Dioscoreae 30 grams,
Fructus Foeniculi 30 grams, Radix Rehmanniae Preparata 80 grams, Fructus Corni 30 grams, Poria 20 grams, the Cortex Eucommiae 5 grams, Fructus Lycii 10 grams, Fructus Psoraleae 10 grams, Herba Cynomorii 10 grams, Rhizoma Acori Graminei 10 grams, Radix Curcumae 10 grams, Pericarpium Citri Reticulatae 10 grams, the Rhizoma Pinelliae 10 grams, Flos Farfarae 10 grams, Radix Ophiopogonis 10 gram, Bulbus Fritillariae Uninbracteatae 10 grams, morning glory 10 grams,
Herba Cistanches 10 grams, Radix Glycyrrhizae 10 grams, Fructus Quisqualis 6 grams, Rhizoma Alismatis 30 grams, Radix Angelicae Sinensis 6 grams
Get above-mentioned Chinese herb and pulverize and sieve, mixing is used water pill, and drying is granulated, and is adding appropriate microcrystalline Cellulose, micropowder silica gel and magnesium stearate to be prepared into tablet.
Embodiment 6, capsule
Radix Codonopsis 50 grams, eupolyphaga 20 grams, the Radix Astragali 70 grams, the Rhizoma Atractylodis Macrocephalae 20 grams,
Rhizoma Chuanxiong 15 grams, the Radix Paeoniae Alba 70 grams, Endothelium Corneum Gigeriae Galli 15 grams, Rhizoma Dioscoreae 70 grams,
Fructus Foeniculi 70 grams, Radix Rehmanniae Preparata 120 grams, Fructus Corni 70 grams, Poria 30 grams, the Cortex Eucommiae 15 grams, Fructus Lycii 20 grams, Fructus Psoraleae 20 grams, Herba Cynomorii 20 grams, Rhizoma Acori Graminei 20 grams, Radix Curcumae 20 grams, Pericarpium Citri Reticulatae 20 grams, the Rhizoma Pinelliae 20 grams, Flos Farfarae 20 grams, Radix Ophiopogonis 20 gram, Bulbus Fritillariae Uninbracteatae 20 grams, morning glory 20 grams,
Herba Cistanches 20 grams, Radix Glycyrrhizae 20 grams, Fructus Quisqualis 12 grams, Rhizoma Alismatis 70 grams, Radix Angelicae Sinensis 12 grams.
Get above-mentioned Chinese herb and pulverize and sieve, mixing is used water pill, and drying is granulated, and adds appropriate amount of starch, and the adjuvants such as magnesium stearate are granulated, granulate, and the capsule of packing into No. 1, and get final product.
Embodiment 7, oral liquid
Radix Codonopsis 17.5 grams, eupolyphaga 6.5 grams, the Radix Astragali 25 grams, the Rhizoma Atractylodis Macrocephalae 6 grams,
Rhizoma Chuanxiong 4.5 grams, the Radix Paeoniae Alba 25 grams, Endothelium Corneum Gigeriae Galli 6.5 grams, Rhizoma Dioscoreae 25 grams, Fructus Foeniculi 25 grams, Radix Rehmanniae Preparata 50 grams, Fructus Corni 25 grams, Poria 13 grams, the Cortex Eucommiae 5 grams, Fructus Lycii 7.5 grams, Fructus Psoraleae 7.5 grams, Herba Cynomorii 7.5 grams, Rhizoma Acori Graminei 7.5 grams, Radix Curcumae 7.5 grams, Pericarpium Citri Reticulatae 7.5 grams, the Rhizoma Pinelliae 7.5 grams, Flos Farfarae 7.5 grams, Radix Ophiopogonis 7.5 gram, Bulbus Fritillariae Uninbracteatae 7.5 grams, morning glory 7.5 grams, Herba Cistanches 7.5 grams, Radix Glycyrrhizae 7.5 grams, Fructus Quisqualis 3 grams, Rhizoma Alismatis 25 grams, Radix Angelicae Sinensis 4.5 grams.
Get above-mentioned raw material of Chinese medicine, add the water extraction 2 times of 3 times of amounts, obtain aqueous extract, add appropriate sucrose, antiseptic adds water to 1000ml, is distributed into one of 10ml, namely gets oral liquid.
Embodiment 8, granule
Radix Codonopsis 70 grams, eupolyphaga 26 grams, the Radix Astragali 100 grams, the Rhizoma Atractylodis Macrocephalae 24 grams,
Rhizoma Chuanxiong 18 grams, the Radix Paeoniae Alba 100 grams, Endothelium Corneum Gigeriae Galli 26 grams, Rhizoma Dioscoreae 100 grams, Fructus Foeniculi 100 grams, Radix Rehmanniae Preparata 200 grams, Fructus Corni 100 grams, Poria 52 grams, the Cortex Eucommiae 20 grams, Fructus Lycii 30 grams, Fructus Psoraleae 30 grams, Herba Cynomorii 30 grams, Rhizoma Acori Graminei 30 grams, Radix Curcumae 30 grams, Pericarpium Citri Reticulatae 30 grams, the Rhizoma Pinelliae 30 grams, Flos Farfarae 30 grams, Radix Ophiopogonis 30 gram, Bulbus Fritillariae Uninbracteatae 30 grams, morning glory 30 grams, Herba Cistanches 30 grams, Radix Glycyrrhizae 30 grams, Fructus Quisqualis 18 grams, Rhizoma Alismatis 100 grams, Radix Angelicae Sinensis 18 grams.
Get above-mentioned Chinese herb and pulverize and sieve, mixing is used water pill, and drying adds appropriate dextrin, steviosin, dry granulation, and granulate, packing, and get final product.
Embodiment 9, pill of the present invention preparation
Radix Codonopsis 35 grams, eupolyphaga 13 grams, the Radix Astragali 50 grams, the Rhizoma Atractylodis Macrocephalae 12 grams,
Rhizoma Chuanxiong 9 grams, the Radix Paeoniae Alba 50 grams, Endothelium Corneum Gigeriae Galli 13 grams, Rhizoma Dioscoreae 50 grams,
Fructus Foeniculi 50 grams, Radix Rehmanniae Preparata 100 grams, Fructus Corni 50 grams, Poria 26 grams,
The Cortex Eucommiae 10 grams, Fructus Lycii 15 grams, Fructus Psoraleae 15 grams, Herba Cynomorii 15 grams,
Rhizoma Acori Graminei 15 grams, Radix Curcumae 15 grams, Pericarpium Citri Reticulatae 15 grams, the Rhizoma Pinelliae 15 grams,
Flos Farfarae 15 grams, Radix Ophiopogonis 15 gram, Bulbus Fritillariae Uninbracteatae 15 grams, morning glory 15 grams,
Herba Cistanches 15 grams, Radix Glycyrrhizae 15 grams, Fructus Quisqualis 9 grams, Rhizoma Alismatis 50 grams,
Radix Angelicae Sinensis 9 grams.
Get above-mentioned raw material of Chinese medicine, add the water extraction 2 times of 3 times of amounts, extracting solution is condensed into extractum, and drying is granulated, and be get final product.
Embodiment 10, pill of the present invention preparation
Radix Codonopsis 12 grams, eupolyphaga 4 grams, the Radix Astragali 17 grams, the Rhizoma Atractylodis Macrocephalae 4 grams,
Rhizoma Chuanxiong 3 grams, the Radix Paeoniae Alba 17 grams, Endothelium Corneum Gigeriae Galli 4 grams, Rhizoma Dioscoreae 17 grams, Fructus Foeniculi 17 grams, Radix Rehmanniae Preparata 33 grams, Fructus Corni 17-gram, Poria 9 grams,
The Cortex Eucommiae 3 grams, Fructus Lycii 5 grams, Fructus Psoraleae 5 grams, Herba Cynomorii 5 grams,
Rhizoma Acori Graminei 5 grams, Radix Curcumae 5 grams, Pericarpium Citri Reticulatae 5 grams, the Rhizoma Pinelliae 5 grams,
Flos Farfarae 5 grams, Radix Ophiopogonis 5 gram, Bulbus Fritillariae Uninbracteatae 5 grams, morning glory 5 grams, Herba Cistanches 5 grams, Radix Glycyrrhizae 5 grams, Fructus Quisqualis 3 grams, Rhizoma Alismatis 17 grams,
Radix Angelicae Sinensis 3 grams.
Preparation method is with embodiment 1.
Embodiment 10, pill of the present invention preparation
Radix Codonopsis 105 grams, eupolyphaga 39 grams, the Radix Astragali 150 grams, the Rhizoma Atractylodis Macrocephalae 36 grams,
Rhizoma Chuanxiong 27 grams, the Radix Paeoniae Alba 150 grams, Endothelium Corneum Gigeriae Galli 39 grams, Rhizoma Dioscoreae 150 grams, Fructus Foeniculi 150 grams, Radix Rehmanniae Preparata 300 grams, Fructus Corni 150 grams, Poria 78 grams, the Cortex Eucommiae 30 grams, Fructus Lycii 45 grams, Fructus Psoraleae 45 grams, Herba Cynomorii 45 grams, Rhizoma Acori Graminei 45 grams, Radix Curcumae 45 grams, Pericarpium Citri Reticulatae 45 grams, the Rhizoma Pinelliae 45 grams, Flos Farfarae 45 grams, Radix Ophiopogonis 45 gram, Bulbus Fritillariae Uninbracteatae 45 grams, morning glory 45 grams, Herba Cistanches 45 grams, Radix Glycyrrhizae 45 grams, Fructus Quisqualis 27 grams, Rhizoma Alismatis 150 grams, Radix Angelicae Sinensis 27 grams.
Preparation method is with embodiment 1.
Claims (9)
1. a pharmaceutical composition for the treatment of nephropathy, is characterized in that, is processed into by following raw material of Chinese medicine:
Radix Codonopsis 12-105 gram, eupolyphaga 4-39 gram, Radix Astragali 17-150 gram, Rhizoma Atractylodis Macrocephalae 4-36 gram,
Rhizoma Chuanxiong 3-27 gram, Radix Paeoniae Alba 17-150 gram, Endothelium Corneum Gigeriae Galli 4-39 gram, Rhizoma Dioscoreae 17-150 gram, Fructus Foeniculi 17-150 gram, Radix Rehmanniae Preparata 33-300 gram, Fructus Corni 17-150 gram,
Poria 9-78 gram, Cortex Eucommiae 3-30 gram, Fructus Lycii 5-45 gram, Fructus Psoraleae 5-45 gram, Herba Cynomorii 5-45 gram, Rhizoma Acori Graminei 5-45 gram, Radix Curcumae 5-45 gram, Pericarpium Citri Reticulatae 5-45 gram,
Rhizoma Pinelliae 5-45 gram, Flos Farfarae 5-45 gram, Radix Ophiopogonis 5-45 gram, Bulbus Fritillariae Uninbracteatae 5-45 gram,
Morning glory 5-45 gram, Herba Cistanches 5-45 gram, Radix Glycyrrhizae 5-45 gram, Fructus Quisqualis 3-27 gram,
Rhizoma Alismatis 17-150 gram, Radix Angelicae Sinensis 3-27 gram.
2. pharmaceutical composition according to claim 1, is characterized in that, is processed into by following raw material of Chinese medicine:
Radix Codonopsis 17.5-70 gram, eupolyphaga 6.5-26 gram, Radix Astragali 25-100 gram, Rhizoma Atractylodis Macrocephalae 6-24 gram,
Rhizoma Chuanxiong 4.5-18 gram, Radix Paeoniae Alba 25-100 gram, Endothelium Corneum Gigeriae Galli 6.5-26 gram, Rhizoma Dioscoreae 25-100 gram, Fructus Foeniculi 25-100 gram, Radix Rehmanniae Preparata 50-200 gram, Fructus Corni 25-100 gram, Poria 13-52 gram, Cortex Eucommiae 5-20 gram, Fructus Lycii 7.5-30 gram, Fructus Psoraleae 7.5-30 gram, Herba Cynomorii 7.5-30 gram, Rhizoma Acori Graminei 7.5-30 gram, Radix Curcumae 7.5-30 gram, Pericarpium Citri Reticulatae 7.5-30 gram, Rhizoma Pinelliae 7.5-30 gram, Flos Farfarae 7.5-30 gram, Radix Ophiopogonis the 7.5-30 gram, Bulbus Fritillariae Uninbracteatae 7.5-30 gram, morning glory 7.5-30 gram, Herba Cistanches 7.5-30 gram, Radix Glycyrrhizae 7.5-30 gram, Fructus Quisqualis 3-18 gram, Rhizoma Alismatis 25-100 gram, Radix Angelicae Sinensis 4.5-18 gram.
3. pharmaceutical composition according to claim 1, is characterized in that, is processed into by following raw material of Chinese medicine:
Radix Codonopsis 20-50 gram, eupolyphaga 10-20 gram, Radix Astragali 30-70 gram, Rhizoma Atractylodis Macrocephalae 10-20 gram,
Rhizoma Chuanxiong 5-15 gram, Radix Paeoniae Alba 30-70 gram, Endothelium Corneum Gigeriae Galli 10-15 gram, Rhizoma Dioscoreae 30-70 gram,
Fructus Foeniculi 30-70 gram, Radix Rehmanniae Preparata 80-120 gram, Fructus Corni 30-70 gram, Poria 20-30 gram, Cortex Eucommiae 5-15 gram, Fructus Lycii 10-20 gram, Fructus Psoraleae 10-20 gram, Herba Cynomorii 10-20 gram, Rhizoma Acori Graminei 10-20 gram, Radix Curcumae 10-20 gram, Pericarpium Citri Reticulatae 10-20 gram, Rhizoma Pinelliae 10-20 gram, Flos Farfarae 10-20 gram, Radix Ophiopogonis 10-20 gram, Bulbus Fritillariae Uninbracteatae 10-20 gram, morning glory 10-20 gram,
Herba Cistanches 10-20 gram, Radix Glycyrrhizae 10-20 gram, Fructus Quisqualis 6-12 gram, Rhizoma Alismatis 30-70 gram, Radix Angelicae Sinensis 6-12 gram.
4. pharmaceutical composition according to claim 1, is characterized in that, is processed into by following raw material of Chinese medicine:
Radix Codonopsis 35 grams, eupolyphaga 13 grams, the Radix Astragali 50 grams, the Rhizoma Atractylodis Macrocephalae 12 grams,
Rhizoma Chuanxiong 9 grams, the Radix Paeoniae Alba 50 grams, Endothelium Corneum Gigeriae Galli 13 grams, Rhizoma Dioscoreae 50 grams,
Fructus Foeniculi 50 grams, Radix Rehmanniae Preparata 100 grams, Fructus Corni 50 grams, Poria 26 grams,
The Cortex Eucommiae 10 grams, Fructus Lycii 15 grams, Fructus Psoraleae 15 grams, Herba Cynomorii 15 grams,
Rhizoma Acori Graminei 15 grams, Radix Curcumae 15 grams, Pericarpium Citri Reticulatae 15 grams, the Rhizoma Pinelliae 15 grams,
Flos Farfarae 15 grams, Radix Ophiopogonis 15 gram, Bulbus Fritillariae Uninbracteatae 15 grams, morning glory 15 grams,
Herba Cistanches 15 grams, Radix Glycyrrhizae 15 grams, Fructus Quisqualis 9 grams, Rhizoma Alismatis 50 grams,
Radix Angelicae Sinensis 9 grams.
5. pharmaceutical composition claimed in claim 1, add the medicine acceptable carrier to be prepared into any pharmaceutical preparation.
6. pharmaceutical composition claimed in claim 5, it is characterized in that, described medicine acceptable carrier comprises: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, the phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate.
7. the described pharmaceutical composition of claim 5, it is characterized in that, described dosage form comprises: tablet, capsule, oral liquid, suck agent, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, cream, spray, drop, patch.
8. the preparation method of the described pharmaceutical composition of claim 1, comprise the following steps: get raw material of Chinese medicine through decocting in water, obtain water extract, be condensed into cream, take this clear paste as raw material, add the medicine acceptable carrier when needing, make according to the routine techniques of galenic pharmacy.
9. the application of the described pharmaceutical composition of claim 1 in the medicine of preparation treatment nephropathy.
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| CN104013902A (en) * | 2014-06-30 | 2014-09-03 | 陈玲 | Traditional Chinese medicine composition for treating nephritis |
| CN106235126A (en) * | 2016-04-17 | 2016-12-21 | 马鞍山聚力科技有限公司 | The uremic ultra micro nutrition prescription of a kind of preventing and treating and preparation processing method |
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