CN105267711A - Pharmaceutical preparation for treating vertigo - Google Patents
Pharmaceutical preparation for treating vertigo Download PDFInfo
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- CN105267711A CN105267711A CN201510848213.4A CN201510848213A CN105267711A CN 105267711 A CN105267711 A CN 105267711A CN 201510848213 A CN201510848213 A CN 201510848213A CN 105267711 A CN105267711 A CN 105267711A
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations and particularly provides a pharmaceutical preparation for treating vertigo. The pharmaceutical preparation is prepared from the following raw materials: 25 parts of hard melandrium herb, 20 parts of Acanthus ilicifolius, 22 parts of Viburnum nervosum, 28 parts of sharpleaf cayratia root, 18 parts of celastrus flagellaris, 26 parts of maidenhair spleenwort, 15 parts of poria with hostwood, 25 parts of cicada slough, 28 parts of corydalis tuber, 15 parts of glossy privet fruit, 15 parts of cassia twig, 20 parts of keel, 25 parts of selfheal, 20 parts of dogwood, 25 parts of astragalus, 20 parts of gastrodia elata, 15 parts of uncaria and 5 parts of liquorice. The pharmaceutical preparation disclosed by the invention can be used for treating vertigo.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of vertigo and its preparation method and application.
Background technology
Dizzyly refer to blurring of vision or dark and dim eyesight; Swoon and refer to self-induction health or external scene rotary oscillation, astasia.The two often occurs simultaneously, therefore is referred to as dizzy.Slight dizzy person closes order and namely stops.The dizzy person of severe as boat by bus, or with nausea and vomiting, nervously to perspire, even limbs deflection is for the symptom such as falling.For this reason, be bursting to and develop the needs that more medicines for the treatment of vertigo safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of vertigo disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of vertigo, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba melandrii firmi 25 parts, Radix seu Caulis Acanthi Ilicifolii 20 parts, Radix Viburni Cordifolii 22 parts, Radix Cayratiae trifoliae 28 parts, sting luxuriant Celastrus orbiculatus Thunb. 18 parts, Herba asplenii trichomanis 26 parts, Poria cum Radix Pini 15 parts, Periostracum Cicadae 25 parts, Rhizoma Corydalis 28 parts, Fructus Ligustri Lucidi 15 parts, Ramulus Cinnamomi 15 parts, Os Draconis 20 parts, Spica Prunellae 25 parts, Fructus Corni 20 parts, the Radix Astragali 25 parts, 20 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of vertigo, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of vertigo, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment vertigo medicine being used for the treatment of vertigo.
Herba melandrii firmi is the herb of the sturdy Herba Melandrii Aprici of pinkwort.Latin name: SilenefirmaSieb.EtZucc., gathers during 8 ~ JIUYUE seed maturity, dries.Heat-clearing and toxic substances removing; Diuresis; Regulating menstruation.Cure mainly laryngopharynx swelling and pain; (ear booth) ear comes to a head; Dysuria.
Radix seu Caulis Acanthi Ilicifolii is root and the stem of acanthaceous plant Radix seu Caulis Acanthi Ilicifolii, and the whole year can adopt, and cleans section, dries.Lightly seasoned, cold in nature.Control mumps, scrofula.
Radix Viburni Cordifolii is the root of caprifoliaceae plant Xin Ye Caulis Viburni Dilatati.Dispelling the wind and dampness pathogens is numb, bones and muscles pain, falls the damage stasis of blood and coagulates, waist side of body flatulence.
Radix Cayratiae trifoliae is the root of vitaceae Caulis et Folium cayratiae trifoliae, heat-clearing and toxic substances removing.Control lung abscess.
Sting the fruit that luxuriant Celastrus orbiculatus Thunb. is Celastraceae plant Radix Seu Caulis Celastri Flagellaris CelastrusflagellarisRupr., wind-damp dispelling, promoting blood circulation and stopping pain.For rheumatic arthritis, traumatic injury.
Herba asplenii trichomanis is fern Aspleniaceae spleen wort Asplenium trchomanes L. AspleniumtrichomanesL., with all herbal medicine.The four seasons can adopt, and clean, using fresh herb or dry.Heat-clearing and toxic substances removing, regulating menstruation, hemostasis, convergence leukorrhagia stopping.For infantile hyperpyrexia, leucorrhea, menoxenia; Burn and scald is controlled in external, traumatic hemorrhage, furuncle swelling toxin, venom.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science thinks that vertigo can by wind, expectorant, void causes, therefore have " calm do not do dizzy ", " dizziness must be caused by phlegm ", the saying of " dizziness must be due to deficiency ", Herba melandrii firmi of the present invention, Radix seu Caulis Acanthi Ilicifolii, Radix Viburni Cordifolii, Radix Cayratiae trifoliae, sting luxuriant Celastrus orbiculatus Thunb., Herba asplenii trichomanis, Poria cum Radix Pini, Periostracum Cicadae, Rhizoma Corydalis suppressing the hyperactive liver and subsiding YANG, benefiting QI and nourishing blood is monarch drug, Fructus Ligustri Lucidi, Ramulus Cinnamomi, Os Draconis, Spica Prunellae, Fructus Corni, the Radix Astragali, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis liver and kidney tonifying, drying dampness to eliminate phlegm is ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, suppressing the hyperactive liver and subsiding YANG, benefiting QI and nourishing blood, treatment vertigo successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba melandrii firmi 25g, Radix seu Caulis Acanthi Ilicifolii 20g, Radix Viburni Cordifolii 22g, Radix Cayratiae trifoliae 28g, sting luxuriant Celastrus orbiculatus Thunb. 18g, Herba asplenii trichomanis 26g, Poria cum Radix Pini 15g, Periostracum Cicadae 25g, Rhizoma Corydalis 28g, Fructus Ligustri Lucidi 15g, Ramulus Cinnamomi 15g, Os Draconis 20g, Spica Prunellae 25g, Fructus Corni 20g, Radix Astragali 25g, Rhizoma Gastrodiae 20g, Ramulus Uncariae Cum Uncis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba melandrii firmi 25g, Radix seu Caulis Acanthi Ilicifolii 20g, Radix Viburni Cordifolii 22g, Radix Cayratiae trifoliae 28g, sting luxuriant Celastrus orbiculatus Thunb. 18g, Herba asplenii trichomanis 26g, Poria cum Radix Pini 15g, Periostracum Cicadae 25g, Rhizoma Corydalis 28g, Fructus Ligustri Lucidi 15g, Ramulus Cinnamomi 15g, Os Draconis 20g, Spica Prunellae 25g, Fructus Corni 20g, Radix Astragali 25g, Rhizoma Gastrodiae 20g, Ramulus Uncariae Cum Uncis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Herba melandrii firmi 25g, Radix seu Caulis Acanthi Ilicifolii 20g, Radix Viburni Cordifolii 22g, Radix Cayratiae trifoliae 28g, sting luxuriant Celastrus orbiculatus Thunb. 18g, Herba asplenii trichomanis 26g, Poria cum Radix Pini 15g, Periostracum Cicadae 25g, Rhizoma Corydalis 28g, Fructus Ligustri Lucidi 15g, Ramulus Cinnamomi 15g, Os Draconis 20g, Spica Prunellae 25g, Fructus Corni 20g, Radix Astragali 25g, Rhizoma Gastrodiae 20g, Ramulus Uncariae Cum Uncis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, traditional Chinese medicine composition for treating vertigo of the present invention clinical research
4.1 general data: this Chinese medicine composition is applied to clinical observation vertigo case 70 example, 46 ~ 65 years old age.The shortest person of the course of disease 3 months, most elder reaches 4 years, average 2.4 years.
4.2 diagnostic criterias: with reference to " dizzy " (at the beginning of foxtail millet show, Huang Ruxun edits, publishing house of The Fourth Military Medical University, the second edition, 2008) diagnostic point: (1) is dizzy looks thing or self sense of rotation, innervation of shaking for ictal, unstable sense, many excuses position or (with) position variation and bringing out.(2) while of dizzy or with the symptom of the transient ischemias such as other brain stems, as eye disease (amaurosis, light, metamorphopsia, diplopia etc.), internal ear pain, numb limbs and tense tendons or unable, damping off, faintness etc.(3) there is slight Detection of brain stem damage sign, as cornea and (or) pharyngeal hyporeflexia or disappearance, regulate and (or) converge like the spokes of a wheel at the hub obstacle, the pathologic reflex etc. of nystagmus that is spontaneous or that bring out after turning neck compressing side vertebral artery and the positive.(4) measuring blood pressure, Lactoferrin of having a blood test, red blood cell count(RBC) and electrocardiogram, electric audiometry, brainstem evoked potential, cervical X-ray are taken the photograph sheet, transcranial Doppler sonography etc. and are helped and clarify a diagnosis.Have ready conditions and do CT or MRI inspection.(5) except the patients with vertigo that tumor, cerebral trauma, hematopathy, cerebral infarction, cerebral hemorrhage etc. cause.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: clinical symptoms all disappears, and test chamber inspection is normal.Take a turn for the better: clinical symptom relief, the state of an illness is controlled, lab testing improvement or normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 35 | 8 | 25 | 2 | 94.3 |
| Blank group | 35 | 1 | 2 | 32 | 8.6 |
Visible the present invention has good therapeutic effect to vertigo, and toxic and side effects does not occur treatments period.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of vertigo, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba melandrii firmi 25 parts, Radix seu Caulis Acanthi Ilicifolii 20 parts, Radix Viburni Cordifolii 22 parts, Radix Cayratiae trifoliae 28 parts, sting luxuriant Celastrus orbiculatus Thunb. 18 parts, Herba asplenii trichomanis 26 parts, Poria cum Radix Pini 15 parts, Periostracum Cicadae 25 parts, Rhizoma Corydalis 28 parts, Fructus Ligustri Lucidi 15 parts, Ramulus Cinnamomi 15 parts, Os Draconis 20 parts, Spica Prunellae 25 parts, Fructus Corni 20 parts, the Radix Astragali 25 parts, 20 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of vertigo as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of vertigo as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment vertigo medicine of vertigo according to claim 1.
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| CN201510848213.4A CN105267711A (en) | 2015-11-30 | 2015-11-30 | Pharmaceutical preparation for treating vertigo |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106349283A (en) * | 2016-08-23 | 2017-01-25 | 陕西源邦生物技术有限公司 | Preparation method of high-purity phosphatidylserine |
| CN106421442A (en) * | 2016-11-02 | 2017-02-22 | 杨均初 | Traditional Chinese medicine composition for treating vertigo and preparation method thereof |
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| CN1105876A (en) * | 1994-01-31 | 1995-08-02 | 贺易庭 | "Dingxuan" medicine for radically treating dizziness disease |
| CN103446454A (en) * | 2012-05-30 | 2013-12-18 | 孔祥军 | Traditional Chinese medicine for treating dizziness |
| CN103690866A (en) * | 2012-09-28 | 2014-04-02 | 青岛信立德中药技术研究开发有限公司 | A traditional Chinese medicine composition used for treating vertigo |
| CN104623325A (en) * | 2013-11-12 | 2015-05-20 | 青岛食之礼中草药研究所 | Traditional Chinese medicine for treating true vertigo |
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2015
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Patent Citations (5)
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| CN1105876A (en) * | 1994-01-31 | 1995-08-02 | 贺易庭 | "Dingxuan" medicine for radically treating dizziness disease |
| CN103446454A (en) * | 2012-05-30 | 2013-12-18 | 孔祥军 | Traditional Chinese medicine for treating dizziness |
| CN103690866A (en) * | 2012-09-28 | 2014-04-02 | 青岛信立德中药技术研究开发有限公司 | A traditional Chinese medicine composition used for treating vertigo |
| CN104623325A (en) * | 2013-11-12 | 2015-05-20 | 青岛食之礼中草药研究所 | Traditional Chinese medicine for treating true vertigo |
| CN104906366A (en) * | 2015-06-22 | 2015-09-16 | 王菊明 | Pharmaceutical preparation for treating delayed menorrhea |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106349283A (en) * | 2016-08-23 | 2017-01-25 | 陕西源邦生物技术有限公司 | Preparation method of high-purity phosphatidylserine |
| CN106421442A (en) * | 2016-11-02 | 2017-02-22 | 杨均初 | Traditional Chinese medicine composition for treating vertigo and preparation method thereof |
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Application publication date: 20160127 |