CN105434738A - Traditional Chinese medicine composition for treating ADHD (Attention Deficit Hyperactivity Disorder) and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating ADHD (Attention Deficit Hyperactivity Disorder) and preparation method thereof Download PDFInfo
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- CN105434738A CN105434738A CN201610003608.9A CN201610003608A CN105434738A CN 105434738 A CN105434738 A CN 105434738A CN 201610003608 A CN201610003608 A CN 201610003608A CN 105434738 A CN105434738 A CN 105434738A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating ADHD (Attention Deficit Hyperactivity Disorder) and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 60 to 120 parts of radix pseudostellariae, 50 to 150 parts of poria cocos, 50 to 150 parts of rhizoma atractylodis macrocephalae, 50 to 150 parts of radix paeoniae alba, 50 to 150 parts of uncaria tomentosa, 10 to 40 parts of scorpio, 20 to 80 parts of pericarpium citri reticulatae, 15 to 75 parts of rhizoma pinellinae praeparata, 50 to 150 parts of hawthorn, 10 to 40 parts of radix glycyrrhizae preparata and 70 to 130 parts of endothelium corneum gigeriae galli. The preparation method of the traditional Chinese medicine composition comprises the steps of a, extracting rhizoma atractylodis macrocephalae and pericarpium citri reticulatae volatile oil; b, preparing dry extract powder of hawthorn and radix glycyrrhizae preparata; c, preparing sediment of radix pseudostellariae and poria cocos; d, preparing dry extract powder of radix paeoniae alba, uncaria tomentosa, scorpio and rhizoma pinellinae praeparata; e, preparing endothelium corneum gigeriae galli powder; f, preparing a volatile oil and beta-cyclodextrin inclusion compound; g, granulating by mixing active dry extract powder, the sediment and the endothelium corneum gigeriae galli powder with sucrose powder and dextrin. The traditional Chinese medicine composition for treating ADHD, disclosed by the invention, is simpler in preparation technology and has the advantages that the treating effect is remarkable, the dosage is small, the side effects are small, and the like; meanwhile, the medicine dosage can be greatly reduced, the traditional Chinese medicine composition is more suitable for a child to take, and the cost is preiswert.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of hyperkinetic syndrome and preparation method thereof.
Background technology
Hyperkinetic syndrome is otherwise known as Cerebral function slight maladjustment dysfunction syndrome clinically.This disease often betides preterm children, main manifestations be absent minded, frequent activity, emotion are restless etc., and self-contr ol power is poor, therefore is also called attention deficit hyperactivity disorder, this disease brings great impact to the daily life of children's and study.It is generally acknowledged that hyperkinetic syndrome is a kind of behavior disease caused by the many factors such as heredity, psychology, environment, is psychology, biological, the interactional result of the social many factors of environment.
To the treatment of hyperkinetic syndrome, mainly contain Drug therapy and psychotherapy, sometimes need both to combine, to have given play to best therapeutic effect.At present, the medicine mainly doping of doctor trained in Western medicine, can regulate dopamine and noradrenaline levels in infant body, make infant visual cognitive ability, reduces impulsion.Both has certain side effect, as caused appetite to decline and weight loss, stomachache, headache, irritability, insomnia etc., or causes Nausea and vomiting, and can not be interrupted.Comparatively speaking, Chinese traditional treatment has obvious advantage, and its advantage does not find toxic and side effects, although onset is comparatively slow, curative effect is long, decreases coming off in treatment.But owing to causing the factor of hyperkinetic syndrome complicated and changeable, be difficult to symptomatic treatment, therefore, the new Chinese medicine developing a kind of special for treating hyperkinetic syndrome is the problem being badly in need of at present solving.
Summary of the invention
For existing hyperkinetic syndrome medicine Problems existing, the present invention is based on famous traditional Chinese medical science professor prescription, Chinese medicine composition of a kind for the treatment of hyperkinetic syndrome newly and preparation method thereof is provided, effective in cure good, the feature that few side effects, dosage are little, economical and practical of this medical instrument, can bring better benefit for society.
For solving the problem, the technical solution used in the present invention is as follows:
Treat a Chinese medicine composition for hyperkinetic syndrome, this Chinese medicine composition is at least made up of the raw material of following parts by weight: Radix Pseudostellariae 60-120 part, Poria 50-150 part, Rhizoma Atractylodis Macrocephalae 50-150 part, Radix Paeoniae Alba 50-150 part, Ramulus Uncariae Cum Uncis 50-150 part, Scorpio 10-40 part, Pericarpium Citri Reticulatae 20-80 part, Rhizoma Pinelliae Preparatum 15-75 part, Fructus Crataegi 50-150 part, Radix Glycyrrhizae Preparata 10-40 part, Endothelium Corneum Gigeriae Galli 70-130 part.
Preferably, this Chinese medicine composition is at least made up of the raw material of following parts by weight: Radix Pseudostellariae 100 parts, 100 parts, Poria, the Rhizoma Atractylodis Macrocephalae 100 parts, the Radix Paeoniae Alba 100 parts, Ramulus Uncariae Cum Uncis 100 parts, Scorpio 30 parts, Pericarpium Citri Reticulatae 50 parts, Rhizoma Pinelliae Preparatum 50 parts, Fructus Crataegi 100 parts, Radix Glycyrrhizae Preparata 30 parts, Endothelium Corneum Gigeriae Galli 100 parts.
Preferred, described Chinese medicine composition is granule, and in every gram of this Chinese medicine composition, the content of albiflorin is no less than 5.81 milligrams.
Treat a preparation method for the Chinese medicine composition of hyperkinetic syndrome, it is characterized in that comprising the following steps: the volatile oil of a reflux, extract, Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae mixture; Mother solution in filtrate and step a, by step a gained Chinese medicine slag and Fructus Crataegi, Radix Glycyrrhizae Preparata mixing decocting liquid filtering, merges, adds ethanol and filter in amalgamation liquid by b, and filtrate concentrate drying gets dry extract powder; C Radix Pseudostellariae, Poria decocting liquid filter, and filter to obtain precipitation in filtrate after adding ethanol; Filter after the d Radix Paeoniae Alba, Ramulus Uncariae Cum Uncis, Scorpio, Rhizoma Pinelliae Preparatum decocting liquid, filtrate concentrate drying gets dry extract powder; The powder process of e Endothelium Corneum Gigeriae Galli is sieved; F adds ethanol and makes volatile oil alcoholic solution in the obtained volatile oil of step a, is slowly joined in beta-schardinger dextrin-aqueous solution by described volatile oil alcoholic solution and is uniformly mixed, filter and obtain precipitation after mixed solution stand at low temperature; Step b, each material of c, d, e, f gained are mixed homogeneously with cane sugar powder, dextrin by g, granulate dry after adding alcoholic solution.
Preferably, reflux, extract, described in step a comprises the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae mixture and water is soaked 1 hour, cohobation 7h by the weight ratio of 1:3.
Preferably, step b prepares dried cream powder and comprises step a Chinese medicine slag, Fructus Crataegi, Radix Glycyrrhizae Preparata mixture and water are decocted 2 times by the weight ratio of 1:10, amalgamation liquid being concentrated into crude drug concentration is be cooled to room temperature after 0.5g/ml, slowly add ethanol under agitation, stop when in solution, the volume fraction of alcohol is 60% dripping, filter after leaving standstill 12h at solution being moved to 4 DEG C, filtrate is dry.
Preferably, step c preparation precipitates to comprise and Radix Pseudostellariae, Poria mixture and water is decocted 2 times by the weight ratio of 1:10, filter after collecting decoction, filtrate being concentrated into crude drug concentration is be cooled to room temperature after 1g/ml, in concentrated solution, slowly ethanol is added under stirring state, stop when in solution, the volume fraction of alcohol is 80% dripping, at solution being moved to 4 DEG C, centrifugal filtration after standing 24h, will precipitate drying.
Preferably, steps d is prepared dried cream powder and is comprised the Radix Paeoniae Alba, Ramulus Uncariae Cum Uncis, Scorpio, Rhizoma Pinelliae Preparatum mixture and water are decocted 2 times by the weight ratio of 1:10, filters, by filtrate concentrate drying after collecting decoction.
Preferably, in step f, the weight ratio of volatile oil, ethanol, beta-schardinger dextrin-, water is 1:7:7:12, also need before filtration drying by mixed solution 60 DEG C stir 1 hour, be placed on 4 DEG C at leave standstill 24 hours.
Preferably, in step g, the gross weight of cane sugar powder and dextrin is 2:1 with the ratio of step b, each material gross weight of c, d, f gained, and described volumes of aqueous ethanol mark is 70%, and baking temperature is 60 DEG C, 5 hours drying times.
A kind of Chinese medicine composition for the treatment of hyperkinetic syndrome provided by the invention has used the prescription of famous traditional Chinese medical science professor, cure mainly the hyperkinetic syndrome that insufficiency of the spleen liver-yang hyperactivity causes, Fang Zhongyong Radix Pseudostellariae, Poria, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, Fructus Crataegi, Endothelium Corneum Gigeriae Galli dyspepsia and intestinal stasis relieving, the Radix Paeoniae Alba, Radix Glycyrrhizae yin fluid astringing easing the affected liver, Ramulus Uncariae Cum Uncis, Scorpio suppressing the hyperactive liver to relieve the wind syndrome, Pericarpium Citri Reticulatae, Rhizoma Pinelliae dampness and in, the advantages such as this medical instrument is effective in cure significantly, dosage is little, side effect is little, and greatly reduce drug administration amount, be more suitable for children taking and price is economical.
Detailed description of the invention
For making those skilled in the art understand technical scheme of the present invention and beneficial effect further, be described in detail below in conjunction with specific embodiment.
Radix Pseudostellariae, sweet in the mouth bitterness is put down, return spleen lung meridian, has effect of replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung, and, inappetence, after being ill weakness tired for insufficiency of the spleen body, deficiency of both vital energy and Yin, spontaneous perspiration are thirsty, dryness of the lung dry cough.Poria, slightly sweet flavor is put down, and GUIXIN, lung, spleen, kidney channel, have the effect of promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming, have loose bowels for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, loose stool, irritability, palpitation with fear insomnia.The Rhizoma Atractylodis Macrocephalae, bitter but sweet flavor is warm in nature, tool invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, has loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement for insufficiency of the spleen lack of appetite, abdominal distention.The Radix Paeoniae Alba, bitter in the mouth acidity is slightly cold, and effect is nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, suppressing liver-YANG, dizzy for blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, limb pain twin, headache.Ramulus Uncariae Cum Uncis, sweet in the mouth is cool in nature, returns liver, pericardium channel, and effect is dispelling wind and relieving convulsion, heat clearing away suppressing the hyperactive liver, dizzy for liver-wind stirring up internally, infantile convulsion tic, hyperpyrexia convulsion, dysphoric cold, children's's night crying due to fright in infant, pre-eclampsia, headache.Scorpio, acrid in the mouth is put down poisonous, returns Liver Channel, and effect is endogenous wind stopping spasmolytic, removing obstruction in the collateral to relieve pain, dispersing pathogen accumulation, for liver-wind stirring up internally, spasm tic, infantile convulsion, apoplexy, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.The Rhizoma Pinelliae, acrid in the mouth is warm in nature poisonous, returns spleen, stomach, lung meridian, and effect is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass,, globus hystericus vexed for damp-phlegm cold-phlegm, cough with asthma abundant expectoration, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache, vomiting regurgitation, breast gastral cavity painful abdominal mass, external treatment carbuncle sucutaneous nodule.Fructus Crataegi, the sweet slightly warm in nature of sour in the mouth, return spleen, stomach, Liver Channel, effect is promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, change turbid blood fat reducing, for meat stagnation, gastral cavilty distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, obstruction of qi in the chest and cardialgia, hernia pain, hyperlipemia.Radix Glycyrrhizae, sweet in the mouth is put down, GUIXIN, lung, spleen, stomach warp, and function is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen extremity contraction anxious pain, carbuncle sore tumefacting virus, cushion toxicity, strong.Endothelium Corneum Gigeriae Galli, sweet in the mouth put down, return spleen, stomach, small intestinal, urinary bladder channel, effect is invigorating the stomach and promoting digestion, arresting seminal emission, treating stranguria fossil, do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission, the puckery pain of stranguria caused by urinary stone, gallbladder-distention hypochondriac pain.In sum, above-mentioned all medicines share, and effectively can treat the hyperkinetic syndrome that insufficiency of the spleen liver-yang hyperactivity causes.
Embodiment 1
Prescription: Radix Pseudostellariae 120g, Poria 150g, Rhizoma Atractylodis Macrocephalae 150g, Radix Paeoniae Alba 150g, Ramulus Uncariae Cum Uncis 150g, Scorpio 40g, Pericarpium Citri Reticulatae 80g, Rhizoma Pinelliae Preparatum 75g, Fructus Crataegi 150g, Radix Glycyrrhizae Preparata 40g, Endothelium Corneum Gigeriae Galli 130g.
This Chinese medicinal preparation method is as follows:
The extraction of a volatile oil: get Rhizoma Atractylodis Macrocephalae 150g, Pericarpium Citri Reticulatae 80g adds 690ml water, soaks 1 hour, and it is for subsequent use that cohobation obtains volatile oil 1.0ml in 7 hours, and the mother solution filtered after distillation, medicinal residues are another device collection respectively.
B Fructus Crataegi, Radix Glycyrrhizae Preparata extract preparation: add water 4200ml in step a gained medicinal residues, 150g Fructus Crataegi, 40g Radix Glycyrrhizae Preparata, decocts 2 times, each 2 hours; Merge the decocting liquid of twice afterwards, filter, in filtrate and step a, mother solution merges; It is about 0.5g/ml that above-mentioned mixed solution is concentrated into crude drug concentration, lets cool to room temperature, slowly adds ethanol while stirring, makes the final volume mark of alcohol in solution reach 60%, solution is put into 4 DEG C of refrigerators and leaves standstill 12 hours; Filter, get the filtrate concentrate drying powder 116.48g that gets dry extract for subsequent use.
The extraction preparation of c Radix Pseudostellariae, Poria: get Radix Pseudostellariae 120g, Poria 150g two taste medical material adds water 2700ml, decoct 2 times, each 2 hours; Merge the decocting liquid of twice, filter, it is about 1g/ml that filtrate is concentrated into crude drug concentration, lets cool to room temperature, slowly adds ethanol while stirring, makes the final volume mark of alcohol in solution reach 80%, solution is put into 4 DEG C of refrigerators and leaves standstill 24 hours; Centrifugal filtration, dry must to precipitate 25.35g for subsequent use.
The extraction preparation of the d Radix Paeoniae Alba etc.: get Radix Paeoniae Alba 150g, Ramulus Uncariae Cum Uncis 150g, Scorpio 40g, Rhizoma Pinelliae Preparatum 75g four Chinese medicine material add water 4150ml, decoct 2 times, each 2 hours; Merge the decocting liquid of twice, filter, the filtrate concentrate drying powder 40.10g that gets dry extract is for subsequent use.
The extraction preparation of e Endothelium Corneum Gigeriae Galli: get Endothelium Corneum Gigeriae Galli 130g and beat powder to cross 80 mesh sieves for subsequent use.
The preparation of f clathrate: step a gained volatile oil is added obtained volatile oil alcoholic solution in 7ml ethanol; Weigh beta-schardinger dextrin-7.015g, join obtained beta-schardinger dextrin-saturated solution in 84ml water; In beta-schardinger dextrin-saturated solution, slowly add volatile oil alcoholic solution, 60 DEG C time, stir 1h, put into 4 DEG C of refrigerators after solution cooling and leave standstill 24 hours, filter, dry that 1.77g precipitation is for subsequent use.
The preparation process of g granule: that step b, c, d, f are prepared amounts to 183.7g dried cream powder, precipitation, Endothelium Corneum Gigeriae Galli powder, amounts to 380.26g cane sugar powder, dextrin mix homogeneously, does wetting agent with the ethanol of 70% volume fraction and granulates, in 60 DEG C of dryings 5 hours.Containing albiflorin 5.10 milligrams in every gram of granule medicament.
Embodiment 2
Prescription: Radix Pseudostellariae 60g, Poria 50g, Rhizoma Atractylodis Macrocephalae 50g, Radix Paeoniae Alba 50g, Ramulus Uncariae Cum Uncis 50g, Scorpio 10g, Pericarpium Citri Reticulatae 20g, Rhizoma Pinelliae Preparatum 15g, Fructus Crataegi 50g, Radix Glycyrrhizae Preparata 10g, Endothelium Corneum Gigeriae Galli 70g.
This Chinese medicinal preparation method is as follows:
The extraction of a volatile oil: get Rhizoma Atractylodis Macrocephalae 50g, Pericarpium Citri Reticulatae 20g adds 210ml water, soaks 1 hour, and it is for subsequent use that cohobation obtains volatile oil 0.4ml in 7 hours, and the mother solution filtered after distillation, medicinal residues are another device collection respectively.
B Fructus Crataegi, Radix Glycyrrhizae Preparata extract preparation: add water 1300ml in step a gained medicinal residues, 50g Fructus Crataegi, 10g Radix Glycyrrhizae Preparata, decocts 2 times, each 2 hours; Collecting decoction, filters, and in filtrate and step a, mother solution merges; Mixed solution being concentrated into crude drug concentration is about 0.5g/ml, lets cool to room temperature, slowly adds ethanol while stirring, makes the final volume mark of alcohol in solution reach 60%; Solution is put into 4 DEG C of refrigerators and leave standstill 12 hours, filter, get the filtrate concentrate drying powder 37.80g that gets dry extract for subsequent use.
The extraction preparation of c Radix Pseudostellariae, Poria: get Radix Pseudostellariae 60g, Poria 50g two taste medical material adds water 1100ml, decoct 2 times, each 2 hours; Merge the decocting liquid of twice, filter; Filtrate being concentrated into crude drug concentration is about 1g/ml, lets cool to room temperature, slowly in solution, adds ethanol while stirring, makes the final volume mark of alcohol in solution reach 80%; Be placed in by solution in 4 DEG C of refrigerators and leave standstill 24 hours, centrifugal filtration, dry must to precipitate 8.79g for subsequent use.
The extraction preparation of the d Radix Paeoniae Alba etc.: Radix Paeoniae Alba 50g, Ramulus Uncariae Cum Uncis 50g, Scorpio 10g, Rhizoma Pinelliae Preparatum 15g four Chinese medicine material add water 1250ml, decoct 2 times, each 2 hours; Collecting decoction, filter, the powder 13.37g that got dry extract by filtrate concentrate drying is for subsequent use.
The extraction preparation of e Endothelium Corneum Gigeriae Galli: Endothelium Corneum Gigeriae Galli 70g beats powder, and to cross 80 mesh sieves for subsequent use.
The preparation of f clathrate: step a gained volatile oil is joined obtained volatile oil alcoholic solution in 2.8ml ethanol; Take beta-schardinger dextrin-2.802g, add water 34ml and obtain beta-schardinger dextrin-saturated solution; Volatile oil alcoholic solution is slowly added in beta-schardinger dextrin-saturated solution; Mixed solution stirs 1h at 60 DEG C, puts into 4 DEG C of refrigerators and leaves standstill 24 hours, filter after cooling, dry that 0.713g precipitation is for subsequent use.
The preparation process of g granule: step b, c, d, f gained are amounted to 60.67g dried cream powder, precipitation, Endothelium Corneum Gigeriae Galli powder, amounts to 121.35g cane sugar powder, dextrin mix homogeneously, does wetting agent granulate, in 60 DEG C of dryings 5 hours with the ethanol of 70% volume fraction.Containing albiflorin 5.68 milligrams in every gram of granule medicament.
Embodiment 3
Prescription: Radix Pseudostellariae 100g, Poria 100g, Rhizoma Atractylodis Macrocephalae 100g, Radix Paeoniae Alba 100g, Ramulus Uncariae Cum Uncis 100g, Scorpio 30g, Pericarpium Citri Reticulatae 50g, Rhizoma Pinelliae Preparatum 50g, Fructus Crataegi 100g, Radix Glycyrrhizae Preparata 30g, Endothelium Corneum Gigeriae Galli 100g.
This Chinese medicinal preparation method is as follows:
The extraction of a volatile oil: get Rhizoma Atractylodis Macrocephalae 100g, Pericarpium Citri Reticulatae 50g adds 450ml water, soaks 1 hour, and it is for subsequent use that cohobation obtains volatile oil 0.7ml in 7 hours, and the mother solution filtered after distillation, medicinal residues are another device collection respectively.
B Fructus Crataegi, Radix Glycyrrhizae Preparata extract preparation: add water 2800ml in step a gained medicinal residues, 100g Fructus Crataegi, 30g Radix Glycyrrhizae Preparata, decocts 2 times, each 2 hours; Collecting decoction, filters, is merged by mother solution in filtrate and step a; Mixed solution being concentrated into crude drug concentration is about 0.5g/ml, lets cool to room temperature, slowly in solution, adds ethanol while stirring, makes the final volume mark of alcohol in solution reach 60%; Solution is put into 4 DEG C of refrigerators and leave standstill 12 hours, filter, get the filtrate concentrate drying powder 77.65g that gets dry extract for subsequent use.
The extraction preparation of c Radix Pseudostellariae, Poria: get Radix Pseudostellariae 100g, Poria 100g two taste medical material adds water 2000ml, decoct 2 times, each 2 hours; Collecting decoction, filter, filtrate being concentrated into crude drug concentration is about 1g/ml, lets cool to room temperature, slowly in solution, adds ethanol while stirring, makes the final volume mark of alcohol in solution reach 80%; Solution is put into 4 DEG C of refrigerators and leave standstill 24 hours, centrifugal filtration, dry must to precipitate 17.57g for subsequent use.
The extraction preparation of the d Radix Paeoniae Alba etc.: get Radix Paeoniae Alba 100g, Ramulus Uncariae Cum Uncis 100g, Scorpio 30g, Rhizoma Pinelliae Preparatum 50g four Chinese medicine material add water 2800ml, decoct 2 times, each 2 hours; Collecting decoction, filter, the powder 26.73g that got dry extract by filtrate concentrate drying is for subsequent use.
The extraction preparation of e Endothelium Corneum Gigeriae Galli: Endothelium Corneum Gigeriae Galli 100g beats powder, and to cross 80 mesh sieves for subsequent use.
The preparation of f clathrate: step a gained volatile oil is added obtained volatile oil alcoholic solution in 4.9ml ethanol; Take beta-schardinger dextrin-4.906g, add obtained beta-schardinger dextrin-saturated solution in 60ml water; In beta-schardinger dextrin-saturated solution, slowly add volatile oil alcoholic solution, mixed solution is stirred 1h at 60 DEG C, put into 4 DEG C of refrigerators after cooling and leave standstill 24 hours, filter, dry that 1.071g precipitation is for subsequent use.
The preparation process of g granule: step b, c, d, f gained amount to 123.02g dried cream powder, precipitation, Endothelium Corneum Gigeriae Galli powder, amount to 246.05g cane sugar powder, dextrin mix homogeneously, do wetting agent granulate, in 60 DEG C of dryings 5 hours with the ethanol of 70% volume fraction.Containing 5.81 milligrams of albiflorin in every gram of granule medicament.
In order to the effect for the treatment of hyperkinetic syndrome Chinese medicine composition prepared by further clear and definite the present invention, we utilize mice to carry out pharmacodynamics test.
Embodiment 4
1 test material
1.1 experimental animal
SPF level KM kind male mice childhood, in 8 week age, weight (20 ± 2) gram, is provided by production and supply portion of institute of lab animals of People's Hospital, Sichuan Prov. of Sichuan Academy of Medical Sciences.
Credit number: SCXK (111) 2,004 1 16, SCXK (111) 2,008 1 16
1.2 test drug
By reagent: Chinese medicine composition prepared by embodiment of the present invention 1-3.
Positive control drug: how dynamic peaceful, Jiangsu Nhwa Pharmaceutical Co., Ltd., lot number: 20150805.
2 contents of the test
2.1 treatment hyperkinetic syndrome Chinese medicine compositions are on the impact of mice behavior
2.1.1 animal grouping, administration
Get 50 male KM mices and be divided into treatment group 1, treatment group 2, treatment group 3, many dynamic peaceful group, blank group at random, often organize 10.Treatment group 1, treatment group 2, treatment group 3 mice gavage the Chinese medicine composition prepared by the present embodiment 1-3 respectively, and many dynamic peaceful group mouse gavagings are how dynamic peaceful, and naive mice gavages 0.9% normal saline.Treatment group 1, treatment group 2, treatment group 3, many dynamic peaceful group, blank group dosage is equivalent to 10 times of child's clinical application amount.Every morning gavages, 1 times/day, gavages 28 days continuously.
2.1.2 index determining
Respectively in the active situation gavaging shooting record mice before and after medicine, every mice observes 30 minutes, observes one group every day
(1) the spontaneous activity in mice time before and after treatment;
(2) before and after treatment, mice erects the number of times of action;
(3) number of times for the treatment of front and back mice pole-climbing time.
2.1.3 date processing
SPSS11.5 software kit is used to carry out statistical analysis.Compare before and after treatment with paired t-test, data result with
represent.
2.1.4 result of the test
The results are shown in Table 1,2,3.
The mice activity time before and after table 1 gavage
Note: compare with blank group, move rather organizes p<0.05 more; Treatment group 3p<0.01.
Result shows, and compares with blank group, and many dynamic peaceful group mice activity time difference has significant (p<0.05); Treatment group 3 mice activity time difference has significant (p<0.01); Treatment group 2 mice activity time difference has significant (p<0.05); Treatment group 1 mice activity time no significant difference.
Result shows, treatment group 2,3 pairs of mice activity time differences have significant, and wherein treatment group 3 more remarkable effect, can reduce the mice activity time.
The number of times that front and back mice erects action treated by table 2
Note: compare with blank group, move rather organizes p<0.05 more; Treatment group 3p<0.05.
Result shows, and compares with blank group, and the number of times difference that many dynamic peaceful group mices erect action has significant (p<0.05); The number of times difference that treatment group 3 mice erects action has significant (p<0.05); Treatment group 2 mice erects the number of times no significant difference of action; Treatment group 1 mice erects the number of times no significant difference of action.
Result shows, the number of times difference that treatment group 3 pairs of mices erect action has significant, can reduce mice and erect number of times.
The front and back mice pole-climbing time treated by table 3
Note: compare with blank group, move rather organizes p<0.05 more; Treatment group 3p<0.05.
Result shows, and compares with blank group, and many dynamic peaceful group mice pole-climbing time differences have significant (p<0.05); Treatment group 3 mice pole-climbing time difference has significant (p<0.05); Treatment group 2 mice pole-climbing time difference is without significant; Treatment group 1 mice pole-climbing time difference is without significant.
Result shows, treatment group 3 pairs of mice pole-climbing time differences have significant, can reduce mice and erect number of times.
2.2 treatment hyperkinetic syndrome Chinese medicine compositions are on the impact of Mouse Weight
2.2.1 animal grouping, administration
Get 50 male KM mice random packet, often organize 10.Every morning gavages, 1 times/day, gavages 28 days continuously.
2.2.2 index determining
Experimental session measures 1 Mouse Weight in every 7 days.
2.2.3 date processing
SPSS11.5 software kit is used to carry out statistical analysis.Compare before and after treatment with paired t-test, data result with
represent.
2.2.4 result of the test
The results are shown in Table 4.
Table 4 represents the mice activity time before and after gavage
Note: compare with blank group, move rather organizes p<0.05 more; Treatment group 3p<0.05.
Result shows, and compares with blank group, and the change of many dynamic peaceful group Mouse Weights has significant (p<0.05); The change for the treatment of group 3 Mouse Weight has significant (p<0.05); The change for the treatment of group 2 Mouse Weight has significant (p<0.05); The change for the treatment of group 1 Mouse Weight has significant (p<0.05).
Result shows, treatment group 1,2,3 pairs of Mouse Weight changes have significant, can increase Mouse Weight.
2.3 treatment hyperkinetic syndrome Chinese medicine compositions are on the impact of DA content in Mice Body
2.3.1 animal grouping, administration
Get the male KM mice random packet that 60 only have hyperkinetic syndrome, often organize 12.Every morning gavages, 1 times/day, gavages 28 days continuously.After perfusion, execution blood sample collection is carried out to mice: perfusion is after two weeks, fasting 1 day, 5 groups of mices are randomly drawed 6 sacrifice respectively and carry out blood sample collection, concrete steps are: use chloral hydrate to anaesthetize mice, carry out eye socket after anesthesia and get blood, amount for taking blood is 0.5 ~ 0.8ml, and blood sample coagulates test tube hold with being equipped with precooled EDTA, put to death mice afterwards, place mice corpse according to the regulation of laboratory.Blood sample is put into centrifuge immediately, and temperature is set to 4 DEG C, and rotating speed is rotating speed 3000rmin
-1, centrifugal 20min, extracts blood plasma 100ul, adds 0.6% perchloric acid 100ul of pre-cooling, is put in refrigerator and leaves standstill 10min in vortex concussion vortex mixer after mixing.Take out in refrigerator and detect sample, centrifuge temperature is set to 4 DEG C, and rotating speed is 12000rmin
-1, centrifugal 15min, get supernatant 100ul be placed in EP pipe constant temperature preserve to be measured.
2.3.2 index determining
Respectively at rear change of measuring DA content in Mice Body in 2 weeks, 4 weeks after perfusion.
2.3.3 date processing
SPSS11.5 software kit is used to carry out statistical analysis.Compare before and after treatment with paired t-test, data result with
represent.
2.3.4 result of the test
The results are shown in Table 5.
DA content in table 5 Mice Body
Note: compare with blank group, move rather organizes p<0.05 more; Treatment group 3p<0.05.
Result shows, and compares with blank group, and in many dynamic peaceful group Mice Bodies, DA changes of contents has significant (p<0.05); In treatment group 1 Mice Body, DA changes of contents has significant (p<0.05); In treatment group 2 Mice Body, DA changes of contents has significant (p<0.05); In treatment group 3 Mice Body, DA changes of contents has significant (p<0.03).
Result shows, in treatment group 1,2,3 pairs of Mice Bodies, DA changes of contents has significant, and wherein treatment group 3 meaning is the most remarkable, can obviously reduce DA content in mice plasma.
2.4 treatment hyperkinetic syndrome Chinese medicine compositions are on the impact of mice serum S100 β albumen
2.4.1 animal grouping, administration
Get 50 male KM mice random packet, often organize 10.Every morning gavages, 1 times/day, gavages 28 days continuously.To mice blood sample collection after perfusion: perfusion is after 4 weeks, and adopt broken end blood taking method, namely left hand thumb and forefinger hold the skin of neck of rat more tightly with back, and makes animal head towards the posture had a down dip.Right handed scissors cuts Mus neck suddenly, cuts off in the part of cervical region precontract 1/2 ~ 4/5, allows drop of blood enter container, in 4 DEG C of cold preservations.The serum S100 β protein content of mice is detected by BCA method.
2.4.2 index determining
The serum S100 β protein content of mice is measured after 4 weeks after perfusion.
2.4.3 date processing
SPSS11.5 software kit is used to carry out statistical analysis.Compare before and after treatment with paired t-test, data result with
represent.
2.4.4 result of the test
The results are shown in Table 6.
The serum S100 β protein content of table 6 mice
Note: compare with blank group, move rather organizes p<0.05 more; Treatment group 3p<0.05.
Result shows, and compares with blank group, and the change of many dynamic peaceful group mice serum S100 β protein contents has significant (p<0.05); Treatment group 3 Mus serum S100 β protein content has significant (p<0.05).
Result shows, treatment group 3 pairs of serum S100 β protein content changes have significant, obviously can raise mice serum S100 β protein content.
The present invention does not limit to above-mentioned preferred forms, anyone other any or akin products identical with the present invention drawn under enlightenment of the present invention, all drops within protection scope of the present invention.
Claims (10)
1. treat a Chinese medicine composition for hyperkinetic syndrome, it is characterized in that this Chinese medicine composition is at least made up of the raw material of following parts by weight: Radix Pseudostellariae 60-120 part, Poria 50-150 part, Rhizoma Atractylodis Macrocephalae 50-150 part, Radix Paeoniae Alba 50-150 part, Ramulus Uncariae Cum Uncis 50-150 part, Scorpio 10-40 part, Pericarpium Citri Reticulatae 20-80 part, Rhizoma Pinelliae Preparatum 15-75 part, Fructus Crataegi 50-150 part, Radix Glycyrrhizae Preparata 10-40 part, Endothelium Corneum Gigeriae Galli 70-130 part.
2. the Chinese medicine composition for the treatment of hyperkinetic syndrome as claimed in claim 1, is characterized in that this Chinese medicine composition is at least made up of the raw material of following parts by weight: Radix Pseudostellariae 100 parts, 100 parts, Poria, the Rhizoma Atractylodis Macrocephalae 100 parts, the Radix Paeoniae Alba 100 parts, Ramulus Uncariae Cum Uncis 100 parts, Scorpio 30 parts, Pericarpium Citri Reticulatae 50 parts, Rhizoma Pinelliae Preparatum 50 parts, Fructus Crataegi 100 parts, Radix Glycyrrhizae Preparata 30 parts, Endothelium Corneum Gigeriae Galli 100 parts.
3. the Chinese medicine composition for the treatment of hyperkinetic syndrome as claimed in claim 2, it is characterized in that: described Chinese medicine composition is granule, in every gram of this Chinese medicine composition, the content of albiflorin is no less than 5.81 milligrams.
4. treat the preparation method of the Chinese medicine composition of hyperkinetic syndrome described in claim 1, it is characterized in that comprising the following steps: the volatile oil of a reflux, extract, Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae mixture; Mother solution in filtrate and step a, by step a gained Chinese medicine slag and Fructus Crataegi, Radix Glycyrrhizae Preparata mixing decocting liquid filtering, merges, adds ethanol and filter in amalgamation liquid by b, and filtrate concentrate drying gets dry extract powder; C Radix Pseudostellariae, Poria decocting liquid filter, and filter to obtain precipitation in filtrate after adding ethanol; Filter after the d Radix Paeoniae Alba, Ramulus Uncariae Cum Uncis, Scorpio, Rhizoma Pinelliae Preparatum decocting liquid, filtrate concentrate drying gets dry extract powder; The powder process of e Endothelium Corneum Gigeriae Galli is sieved; F adds ethanol and makes volatile oil alcoholic solution in the obtained volatile oil of step a, is slowly joined in beta-schardinger dextrin-aqueous solution by described volatile oil alcoholic solution and is uniformly mixed, filter and obtain precipitation after mixed solution stand at low temperature; Step b, each material of c, d, e, f gained are mixed homogeneously with cane sugar powder, dextrin by g, granulate dry after adding alcoholic solution.
5. preparation method as claimed in claim 4, is characterized in that: reflux, extract, described in step a comprises soaks 1 hour, cohobation 7h by the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae mixture and water by the weight ratio of 1:3.
6. preparation method as claimed in claim 4, it is characterized in that: step b prepares dried cream powder and comprises step a Chinese medicine slag, Fructus Crataegi, Radix Glycyrrhizae Preparata mixture and water are decocted 2 times by the weight ratio of 1:10, amalgamation liquid being concentrated into crude drug concentration is be cooled to room temperature after 0.5g/ml, slowly add ethanol under agitation, stop when in solution, the volume fraction of alcohol is 60% dripping, filter after leaving standstill 12h at solution being moved to 4 DEG C, filtrate is dry.
7. preparation method as claimed in claim 4, it is characterized in that: step c preparation precipitates to comprise and Radix Pseudostellariae, Poria mixture and water are decocted 2 times by the weight ratio of 1:10, filter after collecting decoction, filtrate being concentrated into crude drug concentration is be cooled to room temperature after 1g/ml, in concentrated solution, slowly ethanol is added under stirring state, stop when in solution, the volume fraction of alcohol is 80% dripping, at solution being moved to 4 DEG C, centrifugal filtration after standing 24h, will precipitate drying.
8. preparation method as claimed in claim 4, is characterized in that: steps d is prepared dried cream powder and comprised the Radix Paeoniae Alba, Ramulus Uncariae Cum Uncis, Scorpio, Rhizoma Pinelliae Preparatum mixture and water are decocted 2 times by the weight ratio of 1:10, filters, by filtrate concentrate drying after collecting decoction.
9. preparation method as claimed in claim 4, is characterized in that: in step f, the weight ratio of volatile oil, ethanol, beta-schardinger dextrin-, water is 1:7:7:12, also needs mixed solution to stir 1 hour at 60 DEG C before filtration drying, be placed on 4 DEG C at leave standstill 24 hours.
10. preparation method as claimed in claim 4, it is characterized in that: in step g, the gross weight of cane sugar powder and dextrin is 2:1 with the ratio of step b, each material gross weight of c, d, f gained, described volumes of aqueous ethanol mark is 70%, and baking temperature is 60 DEG C, 5 hours drying times.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106038936A (en) * | 2016-07-11 | 2016-10-26 | 孙聪玲 | Qi-tonifying and muscular-spasm-relieving granules combining with seed pressing at auricular points to treat attention-deficit hyperactivity disorder |
| CN109620932A (en) * | 2017-10-09 | 2019-04-16 | 范国华 | A kind of Chinese traditional treatment new method of children's hyperkinetic syndrome |
| CN112773868A (en) * | 2021-03-29 | 2021-05-11 | 赵凤臣 | Traditional Chinese medicine formula for treating attention deficit hyperactivity disorder |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879836A (en) * | 2006-05-13 | 2006-12-20 | 李兰芳 | A medicine for treating children's excessive blink, hyperkinetic syndrome and Tottre's syndrome and method for preparing same |
| CN101129649A (en) * | 2007-08-31 | 2008-02-27 | 浙江大学 | Traditional Chinese medicine compound formulated product for treating hyperkinetic symptom and method of producing the same and use of the same |
| CN101700289A (en) * | 2009-11-02 | 2010-05-05 | 南京师范大学 | Traditional Chinese medicine extract composition for treating gastrointestinal dysfunction or irritable bowel syndrome (IBS), and preparation method and applications thereof in preparation of medicaments |
| CN104306846A (en) * | 2014-09-09 | 2015-01-28 | 宋永花 | Traditional Chinese medicine for treating attention deficit hyperactivity disorder |
| CN104784416A (en) * | 2015-04-24 | 2015-07-22 | 北京中医药大学东方医院 | Traditional Chinese medicine composition for treating Tourette's syndrome and preparation method and application of traditional Chinese medicine composition |
| CN104922371A (en) * | 2015-04-24 | 2015-09-23 | 北京中医药大学东方医院 | Use of combination in preparation of medicine for treating transient and chronic tic disorder |
-
2016
- 2016-01-04 CN CN201610003608.9A patent/CN105434738A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879836A (en) * | 2006-05-13 | 2006-12-20 | 李兰芳 | A medicine for treating children's excessive blink, hyperkinetic syndrome and Tottre's syndrome and method for preparing same |
| CN101129649A (en) * | 2007-08-31 | 2008-02-27 | 浙江大学 | Traditional Chinese medicine compound formulated product for treating hyperkinetic symptom and method of producing the same and use of the same |
| CN101700289A (en) * | 2009-11-02 | 2010-05-05 | 南京师范大学 | Traditional Chinese medicine extract composition for treating gastrointestinal dysfunction or irritable bowel syndrome (IBS), and preparation method and applications thereof in preparation of medicaments |
| CN104306846A (en) * | 2014-09-09 | 2015-01-28 | 宋永花 | Traditional Chinese medicine for treating attention deficit hyperactivity disorder |
| CN104784416A (en) * | 2015-04-24 | 2015-07-22 | 北京中医药大学东方医院 | Traditional Chinese medicine composition for treating Tourette's syndrome and preparation method and application of traditional Chinese medicine composition |
| CN104922371A (en) * | 2015-04-24 | 2015-09-23 | 北京中医药大学东方医院 | Use of combination in preparation of medicine for treating transient and chronic tic disorder |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106038936A (en) * | 2016-07-11 | 2016-10-26 | 孙聪玲 | Qi-tonifying and muscular-spasm-relieving granules combining with seed pressing at auricular points to treat attention-deficit hyperactivity disorder |
| CN106038936B (en) * | 2016-07-11 | 2019-11-29 | 孙聪玲 | A kind of joint ear acupuncture point buries the QI invigorating antispastic particle of beans treatment children's hyperkinetic syndrome |
| CN109620932A (en) * | 2017-10-09 | 2019-04-16 | 范国华 | A kind of Chinese traditional treatment new method of children's hyperkinetic syndrome |
| CN112773868A (en) * | 2021-03-29 | 2021-05-11 | 赵凤臣 | Traditional Chinese medicine formula for treating attention deficit hyperactivity disorder |
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