CN104173808B

CN104173808B - A kind of Chinese medicine and preparation method thereof for treating flaming-up of the liverfire type hypertension

Info

Publication number: CN104173808B
Application number: CN201410440843.3A
Authority: CN
Inventors: 于美芹
Original assignee: Sichuan Shuang Xin Pharmaceutical Co Ltd
Current assignee: Sichuan Shuang Xin Pharmaceutical Co., Ltd.
Priority date: 2014-09-02
Filing date: 2014-09-02
Publication date: 2018-10-23
Anticipated expiration: 2034-09-02
Also published as: CN104173808A

Abstract

The present invention provides a kind of Chinese medicines and preparation method thereof for treating flaming-up of the liverfire type hypertension, wherein Chinese medicine includes following raw medicinal material：Prunella vulgaris, cassia seed, butterflybush flower, pipewort, the seed of feather cockscomb, rough gentian, wild chrysanthemum, adder-wort, pueraria lobata, bark of ash, the root of fangji, ramulus mori, Common St.Paulswort Herbs, clerodendron trichotomum, luffa, rhizoma dioscoreae nipponicae, Ramulus Taxilli, keel, mother-of-pearl, concha mauritiae, bluish dogbane, uncaria, stiff silkworm, indigo naturalis, infected foxtail millet spike bran, le three-coloured amaranth and stringy stonecrop.Beneficial effects of the present invention：The present invention has the effect of clearing liver-fire, eliminating dampness and heat, cures mainly flaming-up of the liverfire type hypertension, it using Traditional Chinese medical theory, is recycled by adjusting whole blood, adjusts blood viscosity etc., diagnosis and treatment is carried out on the basis of Overall View, carries out magnetic target therapy for similar disease, drug effect is gone directly lesion, indication is wider, significant in efficacy, adverse reaction is less, convenient drug administration, patient is easy to receive, and can carry out clinical market popularization.

Description

A kind of Chinese medicine and preparation method thereof for treating flaming-up of the liverfire type hypertension

Technical field

The present invention relates to pharmaceutical technology more particularly to a kind of Chinese medicine for treating flaming-up of the liverfire type hypertension and its preparations Method

Background technology

Hypertension is to continue the disease of hyperpiesia, can cause the diseases such as apoplexy, heart disease, hemangioma, kidney failure, high blood Pressure is a kind of characterized by angiosthenia increases, can be functional with heart, blood vessel, brain and kidney and other organs or organic change Systemic disease, it is divided into essential hypertension and secondary hypertension.There are many reason of hypertension incidence, can be divided into heredity With two aspects of environment.In unused antihypertensive, systolic pressure >=139mmHg and/or diastolic pressure >=89mmHg, by blood Hypertension is divided into 1,2,3 grades by voltage levels.Systolic pressure >=140mmHg and Shu Zhangya <90mmHg is single-row for isolated systolic height Blood pressure.Patient previously has history of hypertension, currently uses antihypertensive, although blood pressure is less than 140/90mmHg, should also examine Break as hypertension.

With related factor of falling ill

1. the age：Incidence has the tendency that increasing and increasing with the age, and person's incidence is high within 40 years old or more.

2. salt：The more persons of salt are taken in, Hypertension incidence is high, has and thinks Shi Yan <2g/ days, hardly happen hypertension; 3-4g/ days, Hypertension incidence 3%, 4-15g/ days, 33.15% , &gt of incidence;20g/ days incidence 30%.

3. weight：Overweight people's incidence is high.

4. heredity：About half hypertensive patient has family history.

5. environment and occupation：There is a working environment of noise, hypertension easily occurs for overwrought mental labour, in city High pressure incidence be higher than rural area.

Etiology and pathogenesis

1. feelings will internal injury innate excess of YANG in the body, in addition angry excessive, liver-yang hyperactivity, sun liter is pneumatic, sends out as dizziness；Or because of long-term sorrow Strongly fragrant angry, qi depression transforming into fire makes liver-yin secretly consume, liver-yang hyperactivity, and sun rises pneumatic, pathogen upward attacking orifices in head, sends out as dizziness.

2, eating and drinking without temperance, impairing the spleen and stomach is weakness of the spleen and the stomach, no resource of generating and transforming QI and blood, YANG-orifices failing to be nourished and make dizziness；Or fertilizer of being addicted to drink Sweet, the full overstrain of famine, wound is good for fortune mistake department in taste, so that indigestion is precise and tiny, accumulatively wet raise phlegm, retention of phlegmatic dampness, failure in sending down turbid yin draws Play dizziness.

3. after wound, operation head injury or operation, qi depression to blood stasis, numbness hinders clear key, sends out as dizziness.

4. physically weak, prolonged illness, lose blood, the kidney being the origin of congenital constitution for overstrain, store essential substances give birth to marrow, if inadequate natural endowment, kidney essense is not filled, or Person's old age deficiency of the kidney or prolonged illness are impairment of the kidney or excess of sexual intercourse,indulgence in sexual activities, leads to deficiency of kidney-essence, cannot give birth to marrow, and the brain being the reservoir of the marrow, marrow sea deficiency, It is all empty up and down, and dizziness occurs.Or chronic deficiency of kidney-YIN, the liver failing to be nourished, so that deficiecny of liver-YIN, cloudy sun not processed, liver-yang hyperactivity, it is dizzy to send out It is dizzy.Serious disease prolonged illness or after losing blood, empty without multiple or overstrain, qi and blood declines few, and qi-blood deficiency, the deficiency of vital energy then does not open up by clear sun, blood Empty then brain is become homeless foster, and dizziness can all occur.

High blood pressure is by stages：

The first phase：Blood pressure is horizontal up to Definite Hypertension, clinic is not in the mood for, brain, renal damage sign.

The second phase：Blood pressure is horizontal up to Definite Hypertension, and has a following person 1. physical examination, x-ray, electrocardiogram or ultrasonic cardiography Illustrate left ventricle dilation.2. funduscopy, Fundus oculi artery is universal or local stenosis.3. albuminuria or creatinine concentration of plasma slightly increase It is high.

The third phase：Blood pressure is horizontal up to Definite Hypertension, and has a following person;1. cerebral hemorrhage or hypertensive encephalopathy.2. the heart Force failure.3. renal failure.4. fundus hemorrhage or exudation, companion or be not accompanied by papilledema.5. angina pectoris, cardiac muscle stalk Plug, cerebral thrombosis.

Hypertension with traditional Chinese Medical classification：

1, liver-yang hyperactivity symptom：Dizziness and tinnitus is had a headache and swollen, and labor, angry exacerbation are met, and limb fiber crops are trembled, insomnia and dreamful sleep, irritable Irritability, red tongue with yellowish fur, veins string.

2, liver-fire flaming symptom：Dizzy and pain, gesture is more acute, red eyes and bitter taste in the mouth, distending pain in the chest and hypochondrium, irritable, few dreaminess of sleeping, Urine is yellow, dry and hard excrement, red tongue with yellowish fur, wiry and frequent pulse.

3, the turbid upper illiteracy symptom of phlegm：Dizziness, heaviness of the head as being covered are rotated depending on object, uncomfortable in chest to do evil, vomiting sputum, deficiency of food somnolence, and tongue is white It is greasy, wiry and rolling pulse.

4, obstruction of the orifices by blood stasis symptom：Dizziness and headache, it is simultaneous to see forgetful, insomnia, palpitaition, lassitude, Hiccough and deaf, face purple lips Secretly, tongue petechia or ecchymosis, stringy and hesitant pulse or thin puckery.

5, deficiency of qi and blood symptom：It has a dizzy spell, it is dynamic then aggravate, Lao Zefa is met, complexion an ancient wine vessel made of horn is white, lustrelessness of the nails, spiritlessness and weakness, Palpitation and sleeplessness, receives poor deficiency of food, and loose stool, pale tongue with thin fur is white, and arteries and veins is thin and delicate.

6, deficiency of liver-yin and kidney-yin symptom：Dizziness long endlessly, sleep forgetful hair less, vexed dry, tinnitus by hypopsia, two xerophtalmias, Spiritlessness and weakness, soreness of waist and knee, seminal emission, red tongue with thin fur, small and wiry pulse.

Western medical treatment hypertension drug is treated：

（One）Angiotensin converting enzyme inhibitor：At present using captopril, enalapril.

（Two）Calcium antagonist：It is that one group of chemical constitution is different, the drug that mechanism of action is also not quite similar.Due to inhibit calcium from Son is by the interior stream of calcium channel on cell membrane, thus referred to as calcium-channel antagonists.Common drug has verapamil, thiazolone and nitre Benzene pyridine, nitrendipine.

（Three）Vasodilator：Directly relaxation vascular smooth muscle, expands blood vessel, reduces blood pressure.Common drug has：1. nitre is general Sodium.2. minoxidil.3. Aiselazine.

（Four）Act on the depressor of stomodaeal nervous system.

1. central sympathetic inhibition drug：（1）Clonidine；（2）Ethyldopa.

2. sympathetic block agent.Dust head has arfonad, is used for the treatment of hypertensive encephalopathy.

3. retarding agent after sympathetic ganglion.So that the slightly middle norepinephrine storage in sympathetic nerve end is exhausted, and reaches decompression Purpose.Common drug has：（1）Guanethidine.（2）Reserpine.

4. adrenergic receptor blocker.

（1）Beta-blocker;Labetalol is the depressor that WHO recommends.Acebutolol.

（2）α receptor blocker：Dust head has prazosin.Doxazosin.

（Five）Diuretic antihypertensive medicine.

1. thiazide：It is most widely used oral diuretic antihypertensive medicine, Aquarium；

2. chlorthalidone；

3. furosemide；

4. dyrenium.

But the western medical treatment hypertension course for the treatment of is longer, a large amount of depressor of prolonged application are also easy to produce drug resistance, lessen the curative effect, Adverse drug reaction is more, personalized medicine, and joint, classification treatment, clinical efficacy is not satisfactory, influences the life matter of patient Amount.

However, Chinese medicine hypertension, has complete theoretical system, has unique advantage and feature：Utilize tradition Theory of traditional Chinese medical science recycles by adjusting whole blood, adjusts blood viscosity etc., diagnosis and treatment is carried out on the basis of Overall View, Magnetic target therapy is carried out for similar disease, drug effect go directly lesion, and indication is wider, significant in efficacy, and adverse reaction is less, is administered Convenient, patient is easy to receive, and can carry out clinical market popularization.

Invention content

Technical problem to be solved by the present invention lies in providing one kind having the effect of clearing liver-fire, clearing heat and promoting diuresis, cures mainly The new drug of hypertension syndrome of liver fire flaring up.The present invention have treatment hypertension, have complete theoretical system, have unique advantage with Feature：It using Traditional Chinese medical theory, is recycled by adjusting whole blood, blood viscosity etc. is adjusted, on the basis of Overall View Diagnosis and treatment is carried out, carries out magnetic target therapy for similar disease, drug effect is gone directly lesion, and indication is wider, significant in efficacy, bad React less, convenient drug administration, patient is easy to receive, and can carry out clinical market popularization.

In order to solve the above technical problem, the present invention provides a kind of Chinese medicines for treating flaming-up of the liverfire type hypertension, including Following raw medicinal material：Prunella vulgaris, butterflybush flower, pipewort, the seed of feather cockscomb, rough gentian, wild chrysanthemum, adder-wort, pueraria lobata, bark of ash, prevents cassia seed Oneself, ramulus mori, Common St.Paulswort Herbs, clerodendron trichotomum, luffa, rhizoma dioscoreae nipponicae, Ramulus Taxilli, keel, mother-of-pearl, concha mauritiae, bluish dogbane, uncaria, deadlock Silkworm, indigo naturalis, infected foxtail millet spike bran, le three-coloured amaranth and stringy stonecrop.

The weight part ratio of each raw medicinal material is in the Chinese medicine：15~30 parts of Prunella vulgaris, 13~27 parts of cassia seed, close illiteracy Spend 11~25 parts, 22~36 parts of pipewort, 23~38 parts of the seed of feather cockscomb, 12~24 parts of rough gentian, 16~29 parts of wild chrysanthemum, adder-wort 30~ 40 parts, 16~27 parts of pueraria lobata, 18~33 parts of bark of ash, 15~31 parts of the root of fangji, 20~35 18~33 parts of Fen, Common St.Paulswort Herbs of ramulus mori, smelly Chinese parasol tree 10~25 parts of paulownia, 13~29 parts of luffa, 12~25 parts of rhizoma dioscoreae nipponicae, 13~29 parts of Ramulus Taxilli, 18~30 parts of keel, mother-of-pearl 12 ~28 parts, 11~26 parts of concha mauritiae, 20~35 parts of bluish dogbane, 10~22 parts of uncaria, 15~28 parts of stiff silkworm, 7~18 parts of indigo naturalis, chaff 14~27 parts of 23~36 parts of old 15~30 Fen, le three-coloured amaranth of paddy and stringy stonecrop.

The weight part ratio of each raw medicinal material is in the Chinese medicine：18~28 parts of Prunella vulgaris, 15~23 parts of cassia seed, close illiteracy Spend 13~22 parts, 25~31 parts of pipewort, 23~30 parts of the seed of feather cockscomb, 14~22 parts of rough gentian, 17~26 parts of wild chrysanthemum, adder-wort 30~ 38 parts, 17~25 parts of pueraria lobata, 19~31 parts of bark of ash, 16~28 parts of the root of fangji, 23~32 19~32 parts of Fen, Common St.Paulswort Herbs of ramulus mori, smelly Chinese parasol tree 11~24 parts of paulownia, 14~25 parts of luffa, 14~24 parts of rhizoma dioscoreae nipponicae, 16~28 parts of Ramulus Taxilli, 19~26 parts of keel, mother-of-pearl 14 ~23 parts, 12~23 parts of concha mauritiae, 24~35 parts of bluish dogbane, 11~21 parts of uncaria, 17~25 parts of stiff silkworm, 7~14 parts of indigo naturalis, chaff 15~25 parts of 23~33 parts of old 15~25 Fen, le three-coloured amaranth of paddy and stringy stonecrop.

The weight part ratio of each raw medicinal material is in the Chinese medicine：18 parts of Prunella vulgaris, 17 parts of cassia seed, 22 parts of butterflybush flower, 28 parts of pipewort, 23 parts of the seed of feather cockscomb, 19 parts of rough gentian, 23 parts of wild chrysanthemum, 35 parts of adder-wort, 25 parts of pueraria lobata, 31 parts of bark of ash, the root of fangji 28 Part, 30 19 parts of Fen, Common St.Paulswort Herbs of ramulus mori, 13 parts of clerodendron trichotomum, 25 parts of luffa, 19 parts of rhizoma dioscoreae nipponicae, 16 parts of Ramulus Taxilli, 26 parts of keel, 17 parts of mother-of-pearl, 21 parts of concha mauritiae, 35 parts of bluish dogbane, 19 parts of uncaria, 17 parts of stiff silkworm, 14 parts of indigo naturalis, 22 Fen, le three-coloured amaranths of infected foxtail millet spike bran 26 parts and 15 parts of stringy stonecrop.

The weight part ratio of each raw medicinal material is in the Chinese medicine：28 parts of Prunella vulgaris, 23 parts of cassia seed, 13 parts of butterflybush flower, 31 parts of pipewort, 30 parts of the seed of feather cockscomb, 22 parts of rough gentian, 17 parts of wild chrysanthemum, 38 parts of adder-wort, 17 parts of pueraria lobata, 26 parts of bark of ash, the root of fangji 16 Part, 32 32 parts of Fen, Common St.Paulswort Herbs of ramulus mori, 24 parts of clerodendron trichotomum, 20 parts of luffa, 14 parts of rhizoma dioscoreae nipponicae, 28 parts of Ramulus Taxilli, 19 parts of keel, 23 parts of mother-of-pearl, 12 parts of concha mauritiae, 24 parts of bluish dogbane, 21 parts of uncaria, 25 parts of stiff silkworm, 8 parts of indigo naturalis, 15 Fen, le three-coloured amaranths of infected foxtail millet spike bran 23 parts and 25 parts of stringy stonecrop.

The weight part ratio of each raw medicinal material is in the Chinese medicine：20 parts of Prunella vulgaris, 15 parts of cassia seed, 19 parts of butterflybush flower, 25 parts of pipewort, 29 parts of the seed of feather cockscomb, 14 parts of rough gentian, 26 parts of wild chrysanthemum, 30 parts of adder-wort, 21 parts of pueraria lobata, 19 parts of bark of ash, the root of fangji 22 Part, 23 23 parts of Fen, Common St.Paulswort Herbs of ramulus mori, 11 parts of clerodendron trichotomum, 14 parts of luffa, 24 parts of rhizoma dioscoreae nipponicae, 27 parts of Ramulus Taxilli, 25 parts of keel, 14 parts of mother-of-pearl, 23 parts of concha mauritiae, 32 parts of bluish dogbane, 11 parts of uncaria, 19 parts of stiff silkworm, 7 parts of indigo naturalis, 25 Fen, le three-coloured amaranths of infected foxtail millet spike bran 33 parts and 21 parts of stringy stonecrop.

When the dosage form of the Chinese medicine is honey refining pill, preparation method includes the following steps：

Step 1：First Prunella vulgaris, cassia seed, butterflybush flower, pipewort, the seed of feather cockscomb, rough gentian, wild chrysanthemum, adder-wort and pueraria lobata are pressed The ratio mixing, distillation crystallize to obtain powder；

Step 2：It takes surplus stock medicinal material to be mixed in the ratio again, adds relative to 2-6 times of 83-94% second measured of mixture Alcohol impregnates 1-2 hour, heating extraction 2 times, 1-1.5 hour each, and merging extracting solution, 124-150 mesh filter, then through the molecule that shuts off Amount is the ultrafiltration column ultrafiltration of 4400-98000, and the medicinal extract that relative density is 1.04 when ultrafiltrate is concentrated under reduced pressure into 87 DEG C becomes group Divide 1；

Step 3：Add 4-6 times to measure water step 2 Chinese medicine slag to impregnate 1-2.5 hours, extract 1 time, extraction time is that 1.5-2 is small When, thickening filtration is medicinal extract shape, is component 2；

Step 4：2 two kinds of medicinal extract of said components 1 and component are condensed into paste, in addition the powder that step 1 obtains, adds honey It is twisted into pill.

When the dosage form of the Chinese medicine is granule, preparation method includes the following steps：

Step 1：The raw medicinal material is mixed in the ratio, it is 85% to add the determining alcohol relative to 4~8 times of mixture ~95% ethyl alcohol is heated to boiling reflux 3~5 hours, and filtering uses percolation slowly to be oozed with the speed of 1~2ml per minute Filter, collect percolate, when being then concentrated under reduced pressure into 50~60 DEG C at 0.06~0.09Mpa of vacuum degree relative density be 1.04~ 1.10 lotion, spray drying, 80~85 DEG C of 160~175 DEG C of the inlet air temperature of spray dryer, leaving air temp then crush At powder, dried cream powder is made；

Step 2：Be added in the dried cream powder of acquisition relative to the cane sugar powder of 0.2~0.4 times of dried cream powder quality and 0.1~ 0.2 times of dextrin, is made particle, in 40~50 DEG C of dryings, obtains granule.

The dosage form of the Chinese medicine is containing tablet, and preparation method includes the following steps：

The first step is mixed Prunella vulgaris, cassia seed, butterflybush flower, pipewort, the seed of feather cockscomb, rough gentian and wild chrysanthemum in the ratio It closes, is impregnated with the ethyl alcohol of 4~6 times of determining alcohol 90%~95% of the mixture quality relative to acquisition, it is small to be heated to reflux 2~4 When after extract, filter；By filter residue again with the second of 2~4 times of determining alcohol 85%~95% of the mixture quality relative to acquisition Alcohol impregnates, and is extracted after being heated to reflux 1~2 hour, filters；Merge filtered fluid twice, ethyl alcohol is recovered under reduced pressure and to be concentrated into liquid dense Degree is 0.8~1.2g crude drugs/mL, twice using the large pore resin absorption column elution that volume is 5L, first with 5 times of resin column volumes Deionized water or distillation water elution, then with the determining alcohols of 3 times of resin column volumes be 90%~95% ethanol elution, collection ethyl alcohol is washed De- liquid is concentrated under reduced pressure and removes ethyl alcohol, and drying is simultaneously ground into powder；

Second step is mixed adder-wort, pueraria lobata, bark of ash, the root of fangji, ramulus mori, Common St.Paulswort Herbs, clerodendron trichotomum and luffa in the ratio It closes, adds the ethyl alcohol heating and refluxing extraction 2 times of 3~5 times of determining alcohol 85%~95% of the mixture quality relative to acquisition, twice Extracting solution merges, and is centrifuged and is cleaned with tube centrifuge, the extracting solution after removal of impurities is concentrated under reduced pressure under conditions of 60 DEG C~70 DEG C To the lotion that relative density at 60 DEG C is 1.20~1.23, the lotion after concentration is dried to powder with spray dryer；

Third walks, and surplus stock medicinal material is mixed in the ratio, adds 2~5 times of the mixture quality relative to acquisition Water impregnate, heating decoct 2~4 hours, filtering；By filter residue again with 1~3 times of water of the mixture quality relative to acquisition It impregnates, heating decocts 1~2 hour, filtering；Merge filtered fluid twice, be concentrated under reduced pressure and remove moisture, drying is simultaneously ground into powder；

4th step, the powder that the first step, second step and third step obtain is mixed, and is further added relative to the mixed of acquisition 0.05~0.1 times of sodium carboxymethyl starch of amount of substance, 0.05~0.1 times of microcrystalline cellulose, mixing are closed, granulation adds after dry Enter the magnesium stearate of 0.01~0.05 times of the mixture quality relative to acquisition, it is then with decompressor that particle is tabletted, Up to containing tablet.

Beneficial effects of the present invention：The Chinese medicine of the present invention has the effect of clearing liver-fire, eliminating dampness and heat, cures mainly irascibility Upper inflammation type hypertension.The present invention, which treats hypertension, complete theoretical system, has unique advantage and feature：Using in tradition Medical knowledge opinion recycles by adjusting whole blood, adjusts blood viscosity etc., diagnosis and treatment, needle are carried out on the basis of Overall View Magnetic target therapy is carried out to similar disease, drug effect go directly lesion, and indication is wider, significant in efficacy, and adverse reaction is less, to prescription Just, patient is easy to receive, and can carry out clinical market popularization.

Specific implementation mode

Traditional Chinese medicine thinks that this disease cause of disease is mostly by feelings will, injury due to diet, and loses blood, caused by wound, overstrain.Its disease Position has caused by violating clear key on brains inanition, YANG-orifices failing to be nourished and convulsive seizure due to phlegm-fire, hemostasis with three dirty functional disturbance of liver,spleen,kidney in clear key It closes, morbidity is in the majority with asthenic symptoms.Clinically real example is more common in the vertigo attack phase, with liver-yang hyperactivity, liver-fire flaming, phlegm it is turbid it is upper cover, Four type of obstruction of the orifices by blood stasis is common.

Therefore, the present invention treats flaming-up of the liverfire type hypertension with clearing liver-fire, and eliminating dampness and heat is main principle of reatment, is selected Prescription：Prunella vulgaris, cassia seed, butterflybush flower, pipewort, the seed of feather cockscomb, rough gentian, wild chrysanthemum, adder-wort, pueraria lobata, bark of ash, the root of fangji, ramulus mori, Common St.Paulswort Herb, clerodendron trichotomum, luffa, rhizoma dioscoreae nipponicae, Ramulus Taxilli, keel, mother-of-pearl, concha mauritiae, bluish dogbane, uncaria, stiff silkworm, indigo naturalis, Infected foxtail millet spike bran, le three-coloured amaranth and stringy stonecrop.

Wherein, Prunella vulgaris, cassia seed, butterflybush flower, pipewort, the seed of feather cockscomb, rough gentian, wild chrysanthemum, adder-wort, pueraria lobata and indigo naturalis are clear Hot purging intense heat and detonicating；Bark of ash, the root of fangji, ramulus mori, Common St.Paulswort Herbs, clerodendron trichotomum, luffa, rhizoma dioscoreae nipponicae, Ramulus Taxilli, infected foxtail millet spike bran, le three-coloured amaranth and Stringy stonecrop clearing away heat and eliminating dampeness dredging collateral；Keel, mother-of-pearl, concha mauritiae are calming the liver, calm the nerves；Bluish dogbane, uncaria, stiff silkworm suppressing liver-YANG, Clearing away heat and relieving the wind syndrome.Complete square compatibility 5 is rigorous, is recycled by adjusting whole blood, adjusts blood viscosity etc., is carried out for similar disease Magnetic target therapy, drug effect are gone directly lesion, and indication is wider, and adverse reaction is less, significant in efficacy.

Wherein, the pharmacology of above-mentioned raw materials medicinal material is as follows：

Prunella vulgaris：It is bitter, pungent, it is cold in nature, enter liver, gallbladder channel,《This warp》：" main fever and chills, scrofula, mouse fistula, head sore break disease, dissipate goitre Gas is tied, foot swells arthritis with fixed pain caused by dampness."《The southern regions of the Yunnan Province book on Chinese herbal medicine》：" liver wind of dispelling, network of passing through control facial paralysis.Row irritability opens liver depression, only arthralgia and myalgia, Ophthal malgia, dissipate scrofula steal, whole body tuberculosis." have and relieve inflammation or internal heat, the effect of improving eyesight, dissipating bind, detumescence, cure mainly red eye, swell pain, mesh pearl nyctalgia, Dizziness of having a headache, scrofula, goiter and tumor, swelling and pain；Thyroid Gland Swell, scrofula, the proliferation of mammary gland, hypertension, hyperglycemia, hyperlipidemia and High blood is viscous to wait card.

Cassia seed：Bitter, cold nature enter large intestine, kidney, Liver Channel, and there is clearing liver-fire, the effect to relax bowel to be used for mesh Red puckery pain, the more tears of photophobia, dizziness of having a headache, mesh is secretly unknown, the cards such as constipation.

Butterflybush flower：It is sweet in flavor, cold nature.Return liver, gallbladder channel.Main glaucoma skin screen, red puckery more eye secretion and tears, Chi Mai in the mesh that disappears, children's bran Beans and infantile malnutrition due to digestive disturbances or intestinalparasites gas attack eye.Function heat-clearing nourishing the liver, removing nebula.For red eye, swell pain, more tear photophobia, clear liver and improve vision, raw screen film of mesh, liver Empty mesh is dark, blurring of vision, relieving cough and asthma, beautifying face and moistering lotion.

Pipewort：Pungent, sweet and neutral.Return liver, lung channel.Screen is moved back in dispelling wind and heat from the body, improving eyesight.For wind-heat hot eyes, swell and ache photophobia, Screen of looking unfamiliar film, headache due to pathogenic wind-heat.

The seed of feather cockscomb：Hardship is slightly cold.Enter the heart, liver two passes through.Effect clears liver and improve vision, clearing heat-fire, removing nebula.It is swollen to cure mainly hot eyes Bitterly, screen of looking unfamiliar film, blurring of vision, high blood pressure, nosebleed epistaxis, skin wind-heat itch, sore tinea.The seed of feather cockscomb controls the hot hot eyes of liver, screen of looking unfamiliar Film, blurring of vision.

Rough gentian：Bitter, it is cold in nature；Return liver, gallbladder channel.Function heat-clearing and damp-drying drug, purging the liver of pathogenic fire is calmed the frightened.Cure mainly jaundice with damp-heat pathogen, urine leaching pain, Swelling of vulva pruritus vulvae, under humid tropics, the alliteration of liver and gall excess fire is had a headache, and red eye, swell pain, deaf ear is swollen, hypochondriac pain bitter taste, pyreticosis convulsion.

Wild chrysanthemum：Cold nature, it is bitter, pungent.Function is clearing heat and detoxicating, detumescence.To staphylococcus aureus, corynebacterium diphtheriae, chain Coccus, Pseudomonas aeruginosa, puncture Shigella, influenza virus, there is inhibiting effect.To furunculosis, ulcer, erysipelas, eczema, dermatitis, wind-heat Flu, abscess of throat, high blood pressure etc. have good curative effect.

Adder-wort：Hardship, it is cool；Return lung, liver, large intestine channel.Heat-clearing is relieving convulsion, manages wet detumescence.Control that pyreticosis is frightened to jerk, lockjaw, dysentery characterized by blood in the stool, carbuncle It is swollen, scrofula, tetany, snakebite and bugbite..

Pueraria lobata：It is cool in nature, it is sweet in flavor, pungent, enter spleen, stomach.Can rising Yang expelling pathogenic factors from muscles and skin, promoting eruption antidiarrheal, relieving restlessness stop temperature.Cure the wound cold, warm Have a headache Xiang Qiang, and dysphoria with smothery sensation is quenched one's thirst, and diarrhea, dysentery, ecchymosis is impermeable, hypertension, angina pectoris, deaf.

Bark of ash：It is pungent, bitter, it is slightly cold.Return stomach, Liver Channel, gallbladder channel.Evacuate pathogenic wind is wet, relaxing muscles and tendons network, clearind deficient heat.For arthralgia pain due to rheumatism, muscle Arteries and veins contraction, skeletal pain, afternoon tidal fever, infantile malnutrition generates heat.Arthralgia pain due to rheumatism, muscle arteries and veins contraction, skeletal pain, no cold-fever inquiring are newly long It can compatibility application.

The root of fangji：It is bitter in taste, it trembles with fear.Enter bladder, spleen, kidney channel.Effect：Inducing diuresis for removing edema, wind-expelling pain-stopping.It cures mainly：Oedema tinea pedis is small Just unfavorable, eczema sore, arthralgia pain due to rheumatism, vascular hypertension.

Ramulus mori：It is bitter；It is mild-natured.Return liver warp.Wind-damp dispelling；Degrading the channel；Row aqueous vapor.Main arthralgia pain due to rheumatism；Apoplexy and hemiplegia；Water Swollen tinea pedis；Human body pruritus.

Common St.Paulswort Herb：It is pungent, bitter, it trembles with fear.Return liver and kidney channel.Wind-damp dispelling, sharp joint, removing toxic substances.For arthralgia pain due to rheumatism, muscles and bones is powerless, Soreness and weakness of waist and knees, quadriplegia, hemiplegia, rubella wet sore.Control apoplectic aphasia in silence, facial paralysis, when saliva spitting.Qi-restoratives, peace The five internal organs, piliation.Bright eyes, black moustache hair, strengthen biceps.Control apoplectic aphasia in silence, facial paralysis, when saliva spitting.Qi-restoratives, peace five It is dirty, piliation.Bright eyes, black moustache hair, strengthen biceps.Function wind-damp dispelling, sharp joint, removing toxic substances.

Clerodendron trichotomum：It is pungent, bitter, sweet, it is cool.Enter Liver Channel, gallbladder channel, the spleen channel.Wind-damp dispelling.It cures mainly：Control arthralgia pain due to rheumatism, hemiplegia, High blood pressure, migraine；Malaria, dysentery, hemorrhoid, ulcer sore scabies..

Luffa：It is cool in nature, it is sweet in flavor.Enter lung, stomach, Liver Channel.Bitter；It is cool in nature.Return lung；Liver；Stomach.Clearing and activating the channels and collaterals；Removing toxic substances Detumescence.Main pain in chest and hypochondrium；Arthralgia pain due to rheumatism, passages through which vital energy circulates contraction, alactation, the cough of lung gesture, carbuncle future sore.

Rhizoma dioscoreae nipponicae：Mild-natured, bitter.Control cough, rheumatic arthritis, Kaschin-Beck disease arthralgia, indigestion, malaria falls Beat damage, Carbuncle swells dislikes sore.It activates blood and relax tendons, the Li Shui that helps digestion, eliminating the phlegm preventing malaria function.

Ramulus Taxilli：Hardship, it is sweet, it is mild-natured.Enter liver and kidney channel.Main metal-inflicted wound goes numbness, and woman's metrorrhagia, internal injury is insufficient, disease more than postpartum, under Milk.Disappear heat, and nourishing chases after wind.Blood-nourishing is radiated, and tea-drinking, relaxing tendons and activating collaterals are made.Can filling liver kidney, strengthening the bones and muscles, wind-damp dispelling, tocolysis.Main waist Knee joint soreness；Muscles and bones impotence is weak；Limbs are hemiplegia；Arthralgia pain due to rheumatism；Head is wrong dizzy；Fetal irritability, metrostaxis.For arthralgia pain due to rheumatism, waist Knees soreness, muscles and bones is powerless, and uterine bleeding passes through more, blood leaking in gestation, fetal irritability；Hypertension.

Keel：It is sweet puckery, it puts down；Enter the heart, liver, kidney, large intestine channel.By perverse trend, tranquilizing mind, only cold dysentery and defecation with blood and pus, woman's metrorrhagia Under band, essence is let out in only dream, and dream is handed over, and controls hematuria, and empty and dreaminess is diverse and confused plus and uses it.Invigorating the spleen, puckery stomach, antidiarrheal dysentery, thirsty disease, pregnancy leakage Tire, discharging fresh blood stool, under metrorrhagia band, profuse nasal bleeding is spitted blood, hidroschesis.Function is transquilization with heavy material tranquillizing the mind by relieving convulsion, arrest sweating controlling nocturnal emission with astringent drugs, stop blooding puckery intestines, raw Flesh sore.It is demented to control frightened epilepsy, palpitation is forgetful, insomnia and dreamful sleep, spontaneous sweating, and stranguria with turbid discharge of passing out semen, hematemesis is had blood in stool, under uterine bleeding band, rush down dysentery Rectal prolapse, ulcer do not close up long.

Mother-of-pearl：It is salty, cold.Return liver, the heart channel of Hang-Shaoyin.Nourishing liver is cloudy, clearing away the liver-fire.Demented frightened epilepsy is controlled, dizzy, tinnitus, heartbeat, pleuroperitoneum It is swollen, women's blood-head, metrorrhagia, the frightened hair convulsion of jerking of children.Soothing the liver, checking exuberance of yang are calmed the frightened, hemostasis.Dizzy, tinnitus is controlled, palpitaition, insomnia is demented, Frightened epilepsy is spitted blood, bleeding from five sense organs or subcutaneous tissue, metrorrhagia.

Concha mauritiae：It is salty, it puts down.Return liver warp.《Tang materia medica》：" heat toxin is gone in improving eyesight."《Medicine materical crude slice is newly joined》：" clearing away heart-fire, soothing the liver is calmed the nerves, Control frightened cautious egersis." calming the liver, tranquillizing the mind by relieving convulsion is clear liver and improved vision.For liver-yang hyperactivity, have a dizzy spell, insomnia of palpitating with fear, hot eyes screen Barrier, blurred vision dim eyesight.Can be antipyretic, reduce vasopermeability, anti-liver injury etc..

Bluish dogbane：Sweetness and bitterness, it is cool.《Shaanxi Chinese herbal medicine》："Refrigerant purging intense heat, cardiac stimulant diuresis, blood pressure lowering.Control heart disease, high blood Pressure, neurasthenia, ephritis edema."It relieves inflammation or internal heat, is depressured, cardiac stimulant, diuresis.Control heart disease, hypertension, neurasthenia, hepatitis abdominal distension, Ephritis edema.

Uncaria：It is sweet, it is bitter, it is slightly cold；Enter Liver Channel, the heart channel of Hang-Shaoyin.《Detailed outline》：" the big number of people revolves dizzy, suppressing liver-wind, except the heart is warm, in children Fish abdominal pain, macular eruption rash."《Tang materia medica》：" uncaria goes out Liang Zhou.Leaf is elongated, spinosity between stem, if shape fishhook person." function heat-clearing is flat Liver, relieving convulsion and spasm.Child convulsion, the morbid night crying of babies are cured mainly, excess heat moves wind, eclampsia, dizziness due to hyperactivity of liver-YANG, irascibility distending pain in the head.

Stiff silkworm：It is salty, pungent, it puts down；Return liver, lung, stomach.《Sheng Nong's herbal classic》：" main pediatric epilepsy scared, the morbid night crying of babies go three worms, go out black, It is good to make us complexion, man's the moon ulcer disease."《Compendium of Materia Medica》：" relieve heat phlegm tuberculosis, scrofula, intermittent headache, wind worm dentalgia, skin wind sore are red Poison is had an itch."

Indigo naturalis：It is salty, it trembles with fear.Return liver warp.It is clearing heat and detoxicating, cool blood, arresting convulsion.For febrile virulent maculae, blood-head tells nosebleed, pectoralgia hemoptysis, Aphtha, mumps, larynx numbness, pediatric epilepsy scared.

Infected foxtail millet spike bran：It is light；It is slightly cold.Return large intestine；Spleen；Kidney；Bladder warp.Eliminating dampness and heat.Main oedema；Difficult urination；It is vexed；Mouthful Yearningly；Dysentery；Eczema；Boil.

Le three-coloured amaranth：It is sweet；Cold nature.Cooling blood and hemostasis；Eliminating dampness and heat；Removing toxicity for eliminating carbuncles.Main gastrorrhagia；It has blood in stool；Hemorrhoid blood；Gall-bladder It is scorching；Cholelithiasis；Dysentery；Diarrhea due to damp-heat；Under band；Difficulty and pain in micturition；Abscess of throat；Eczema；Carbuncle swells；Gum is rotten to the corn；Snake bite.

Stringy stonecrop：It is sweet, light, it is cool.Return liver, courage, small intestinl channel.Eliminating dampness and heat, removing toxic substances.For jaundice with damp-heat pathogen, difficult urination, carbuncle Swollen sore, acute hepatitis, chronic hepatitis.

The present invention provides a kind of Chinese medicines for treating flaming-up of the liverfire type hypertension, including following raw medicinal material：Prunella vulgaris is determined Pine torch, butterflybush flower, pipewort, the seed of feather cockscomb, rough gentian, wild chrysanthemum, adder-wort, pueraria lobata, bark of ash, the root of fangji, ramulus mori, Common St.Paulswort Herbs, clerodendron trichotomum, Luffa, rhizoma dioscoreae nipponicae, Ramulus Taxilli, keel, mother-of-pearl, concha mauritiae, bluish dogbane, uncaria, stiff silkworm, indigo naturalis, infected foxtail millet spike bran, le three-coloured amaranth and Stringy stonecrop.

Wherein, the weight part ratio of each raw medicinal material is preferably in Chinese medicine：15~30 parts of Prunella vulgaris, cassia seed 13~27 Part, 11~25 parts of butterflybush flower, 22~36 parts of pipewort, 23~38 parts of the seed of feather cockscomb, 12~24 parts of rough gentian, 16~29 parts of wild chrysanthemum, 30~40 parts of adder-wort, 16~27 parts of pueraria lobata, 18~33 parts of bark of ash, 15~31 parts of the root of fangji, 20~35 Fen, Common St.Paulswort Herbs 18~33 of ramulus mori Part, 10~25 parts of clerodendron trichotomum, 13~29 parts of luffa, 12~25 parts of rhizoma dioscoreae nipponicae, 13~29 parts of Ramulus Taxilli, 18~30 parts of keel, 12~28 parts of mother-of-pearl, 11~26 parts of concha mauritiae, 20~35 parts of bluish dogbane, 10~22 parts of uncaria, 15~28 parts of stiff silkworm, indigo naturalis 7 14~27 parts of~18 parts, 15~30 23~36 parts of Fen, le three-coloured amaranth of infected foxtail millet spike bran and stringy stonecrop.

Wherein, the weight part ratio of each raw medicinal material can also be preferably in Chinese medicine：18~28 parts of Prunella vulgaris, cassia seed 15 ~23 parts, 13~22 parts of butterflybush flower, 25~31 parts of pipewort, 23~30 parts of the seed of feather cockscomb, 14~22 parts of rough gentian, wild chrysanthemum 17~26 Part, 30~38 parts of adder-wort, 17~25 parts of pueraria lobata, 19~31 parts of bark of ash, 16~28 parts of the root of fangji, 23~32 Fen, Common St.Paulswort Herbs 19 of ramulus mori ~32 parts, 11~24 parts of clerodendron trichotomum, 14~25 parts of luffa, 14~24 parts of rhizoma dioscoreae nipponicae, 16~28 parts of Ramulus Taxilli, keel 19~26 Part, 14~23 parts of mother-of-pearl, 12~23 parts of concha mauritiae, 24~35 parts of bluish dogbane, 11~21 parts of uncaria, 17~25 parts of stiff silkworm, blueness 15~25 parts of 7~14 parts of black pigment used by women in ancient times to paint their eyebrows, 15~25 23~33 parts of Fen, le three-coloured amaranth of infected foxtail millet spike bran and stringy stonecrop.

Wherein, in Chinese medicine the weight part ratio of each raw medicinal material by that can be preferably：18 parts of Prunella vulgaris, 17 parts of cassia seed, 22 parts of butterflybush flower, 28 parts of pipewort, 23 parts of the seed of feather cockscomb, 19 parts of rough gentian, 23 parts of wild chrysanthemum, 35 parts of adder-wort, 25 parts of pueraria lobata, bark of ash 31 Part, 28 parts of the root of fangji, 30 19 parts of Fen, Common St.Paulswort Herbs of ramulus mori, 13 parts of clerodendron trichotomum, 25 parts of luffa, 19 parts of rhizoma dioscoreae nipponicae, 16 parts of Ramulus Taxilli, 26 parts of keel, 17 parts of mother-of-pearl, 21 parts of concha mauritiae, 35 parts of bluish dogbane, 19 parts of uncaria, 17 parts of stiff silkworm, 14 parts of indigo naturalis, infected foxtail millet spike bran 22 15 parts of 26 parts of Fen, le three-coloured amaranth and stringy stonecrop.

Wherein, the weight part ratio of each raw medicinal material can also be preferably in Chinese medicine：28 parts of Prunella vulgaris, 23 parts of cassia seed, 13 parts of butterflybush flower, 31 parts of pipewort, 30 parts of the seed of feather cockscomb, 22 parts of rough gentian, 17 parts of wild chrysanthemum, 38 parts of adder-wort, 17 parts of pueraria lobata, bark of ash 26 Part, 16 parts of the root of fangji, 32 32 parts of Fen, Common St.Paulswort Herbs of ramulus mori, 24 parts of clerodendron trichotomum, 20 parts of luffa, 14 parts of rhizoma dioscoreae nipponicae, 28 parts of Ramulus Taxilli, 19 parts of keel, 23 parts of mother-of-pearl, 12 parts of concha mauritiae, 24 parts of bluish dogbane, 21 parts of uncaria, 25 parts of stiff silkworm, 8 parts of indigo naturalis, infected foxtail millet spike bran 15 25 parts of 23 parts of Fen, le three-coloured amaranth and stringy stonecrop.

Wherein, the weight part ratio of each raw medicinal material can also be preferably in Chinese medicine：20 parts of Prunella vulgaris, 15 parts of cassia seed, 19 parts of butterflybush flower, 25 parts of pipewort, 29 parts of the seed of feather cockscomb, 14 parts of rough gentian, 26 parts of wild chrysanthemum, 30 parts of adder-wort, 21 parts of pueraria lobata, bark of ash 19 Part, 22 parts of the root of fangji, 23 23 parts of Fen, Common St.Paulswort Herbs of ramulus mori, 11 parts of clerodendron trichotomum, 14 parts of luffa, 24 parts of rhizoma dioscoreae nipponicae, 27 parts of Ramulus Taxilli, 25 parts of keel, 14 parts of mother-of-pearl, 23 parts of concha mauritiae, 32 parts of bluish dogbane, 11 parts of uncaria, 19 parts of stiff silkworm, 7 parts of indigo naturalis, infected foxtail millet spike bran 25 21 parts of 33 parts of Fen, le three-coloured amaranth and stringy stonecrop.

Step 3:Add 4-6 times to measure water step 2 Chinese medicine slag to impregnate 1-2.5 hours, extract 1 time, extracts 1.5-2 hours and concentrate It is filtered into medicinal extract shape, is component 2；

The present invention will be described in detail below with reference to the drawings of preferred embodiments, whereby to the present invention how applied technology method Technical problem is solved, and the realization process for reaching technique effect can fully understand and implement.

The honey refining pill of 1 present invention of embodiment

Take Prunella vulgaris 18g, cassia seed 17g, butterflybush flower 22g, pipewort 28g, seed of feather cockscomb 23g, rough gentian 19g, wild chrysanthemum 23g, it adder-wort 35g, pueraria lobata 25g, bark of ash 31g, root of fangji 28g, ramulus mori 30g, Common St.Paulswort Herbs 19g, clerodendron trichotomum 13g, luffa 25g, wears Mountain dragon 19g, Ramulus Taxilli 16g, keel 26g, mother-of-pearl 17g, concha mauritiae 21g, bluish dogbane 35g, uncaria 19g, stiff silkworm 17g, indigo naturalis 14g, infected foxtail millet spike bran 22g, le three-coloured amaranth 26g and stringy stonecrop 15g.

Preparation method includes the following steps：

Step 2：It takes surplus stock medicinal material to be mixed in the ratio again, adds the 90% ethyl alcohol leaching relative to 3 times of amounts of mixture Bubble 1 hour, heating extraction 2 times, 1 hour every time, merge extracting solution, the filtration of 140 mesh, then the ultrafiltration for being 4400 through the molecular weight that shuts off Column ultrafiltration, the medicinal extract that relative density is 1.04 when ultrafiltrate is concentrated under reduced pressure into 87 DEG C, becomes component 1；

Step 3:Add 4-6 times to measure water step 2 Chinese medicine slag to impregnate 1 hour, extract 1 time, it is leaching to extract 2 hours thickening filtrations Paste is component 2；

The granule of 2 present invention of embodiment

Take Prunella vulgaris 28g, cassia seed 23g, butterflybush flower 13g, pipewort 31g, seed of feather cockscomb 30g, rough gentian 22g, wild chrysanthemum 17g, it adder-wort 38g, pueraria lobata 17g, bark of ash 26g, root of fangji 16g, ramulus mori 32g, Common St.Paulswort Herbs 32g, clerodendron trichotomum 24g, luffa 20g, wears Mountain dragon 14g, Ramulus Taxilli 28g, keel 19g, mother-of-pearl 23g, concha mauritiae 12g, bluish dogbane 24g, uncaria 21g, stiff silkworm 25g, indigo naturalis 8g, infected foxtail millet spike bran 15g, le three-coloured amaranth 23g and stringy stonecrop 25g.

Preparation method includes the following steps：

Step 1：The raw medicinal material is mixed in the ratio, it is 85% to add the determining alcohol relative to 4 times of mixture Ethyl alcohol is heated to boiling reflux 3 hours, filtering, uses percolation with the speed of 1ml per minute slowly diacolation, collects percolate, The lotion that relative density is 1.04 when being then concentrated under reduced pressure into 60 DEG C at vacuum degree 0.07Mpa, spray drying, spray dryer 160 DEG C of inlet air temperature, 80 DEG C of leaving air temp, be then ground into powder, dried cream powder be made；

Step 2：It is added relative to 0.2 times of cane sugar powder of dried cream powder quality and 0.1 times of paste in the dried cream powder of acquisition Particle is made in essence, in 50 DEG C of dryings, obtains granule.

3 present invention's of embodiment contains tablet

Take Prunella vulgaris 20g, cassia seed 15g, butterflybush flower 19g, pipewort 25g, seed of feather cockscomb 29g, rough gentian 14g, wild chrysanthemum 26g, it adder-wort 30g, pueraria lobata 21g, bark of ash 19g, root of fangji 22g, ramulus mori 23g, Common St.Paulswort Herbs 23g, clerodendron trichotomum 11g, luffa 14g, wears Mountain dragon 24g, Ramulus Taxilli 27g, keel 25g, mother-of-pearl 14g, concha mauritiae 23g, bluish dogbane 32g, uncaria 11g, stiff silkworm 19g, indigo naturalis 7g, infected foxtail millet spike bran 25g, le three-coloured amaranth 33g and stringy stonecrop 21g.

Preparation method includes the following steps：

The first step is mixed Prunella vulgaris, cassia seed, butterflybush flower, pipewort, the seed of feather cockscomb, rough gentian and wild chrysanthemum in the ratio It closes, is impregnated, extracted after being heated to reflux 3 hours, mistake with the ethyl alcohol of 6 times of determining alcohol 95% of the mixture quality relative to acquisition Filter；Filter residue is impregnated with the ethyl alcohol of 3 times of determining alcohol 95% of the mixture quality relative to acquisition again, is heated to reflux 2 hours After extract, filter；Merge filtered fluid twice, it is 1.2g crude drugs/mL that ethyl alcohol, which is recovered under reduced pressure, and is concentrated into liquor strength, utilizes volume For 5L large pore resin absorption column elution twice, first use the deionized water of 5 times of resin column volumes or distill water elution, then with 3 times The determining alcohol of resin column volume is 95% ethanol elution, collects ethanol eluate, is concentrated under reduced pressure and removes ethyl alcohol, and drying is simultaneously ground into Powder；

Second step is mixed adder-wort, pueraria lobata, bark of ash, the root of fangji, ramulus mori, Common St.Paulswort Herbs, clerodendron trichotomum and luffa in the ratio It closes, adds the ethyl alcohol heating and refluxing extraction 2 times of 4 times of determining alcohol 95% of the mixture quality relative to acquisition, extracting solution closes twice And centrifuged and cleaned with tube centrifuge, the extracting solution after removal of impurities is concentrated under reduced pressure under conditions of 70 DEG C relatively close at 60 DEG C Degree is 1.20 lotion, and the lotion after concentration is dried to powder with spray dryer；

Third walks, and surplus stock medicinal material is mixed in the ratio, adds 3 times of water of the mixture quality relative to acquisition It impregnates, heating decocts 3 hours, filtering；Filter residue is impregnated with 3 times of water of the mixture quality relative to acquisition again, heating It decocts 2 hours, filtering；Merge filtered fluid twice, be concentrated under reduced pressure and remove moisture, drying is simultaneously ground into powder；

4th step, the powder that the first step, second step and third step obtain is mixed, and is further added relative to the mixed of acquisition 0.1 times of sodium carboxymethyl starch of amount of substance, 0.1 times of microcrystalline cellulose, mixing are closed, granulation after dry, is added relative to acquisition 0.05 times of mixture quality magnesium stearate, it is then with decompressor that particle is tabletted to get containing tablet.

The present invention provides a kind of Chinese medicine for treating flaming-up of the liverfire type hypertension, and form of Chinese drug can be：Tablet, sugar coated tablet Agent, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral solution, containing tablet, granule, electuary, Honey pill agent, powder, sublimed preparation, solution, injection, suppository, emplastrum, syrup, powder, liniment, enema and patch.

Chinese medicine when in use take by decoction agent, and daily 1 dose, decocting takes at twice, every 10 days as a treatment course；When this Chinese medicine composition is drops in use, 4 times a day, every 7 days as a course for the treatment of；When this Chinese medicine composition be capsule, honey pill agent, Granule, contain tablet in use, 2 times a day, every 9 days as a treatment course.

Toxicity test：

Acute toxicity test：Using NIH mouse 60, SPF grades, half male and half female, 17~24g of weight carries out acute toxicity Experiment.Mouse is randomly divided into two groups, and every group 20, i.e. control group and administration group test preceding fasting 12 hours；By the reality of the present invention The granule for applying the preparation of example 2 is dissolved in water,（A concentration of 5.74g crude drugs/ml, maximum concentration）Gavage, gavage volume are 5ml/ kg（I.e. unit dosage form is 28.7 crude drugs/kg）, control group gives normal saline, is administered 2 times within one day, when dosing interval Between 6 hours, be observed continuously after administration 14 days, and record the toxic reaction and death toll of mouse.The experimental results showed that：With compare Group compares, and mouse has no that notable difference, experiment are observed continuously 14 days after administration, and mouse systemic situation, diet, drinking-water, weight increase Length is normal.The granule LD50&gt of the Mouse oral gavage present invention;28.7 crude drugs/kg, daily maximum dosage-feeding be 57.4 crude drugs/ Kg/ days.The Chinese medicine clinical application amount of the present invention is 4.6g crude drugs/day/people, and in terms of 60KG, average dosage is adult's weight 0.077g crude drugs/kg/ days.By batheroom scale：Mouse（Average weight is in terms of 21g）The dosis tolerata of the Chinese medicine of the oral administration gavage present invention is 745 times of quantity.Therefore the Chinese medicine acute toxicity of the present invention is low, clinical application safety.

Long term toxicity test：The embodiment of the present invention 3 is pressed into 6.43,15.72 and 36.41g crude drugs/kg containing tablet to mouse Continuous use 16 weeks (1.0ml/100g weight, 2 times a day) and be discontinued 4 weeks after, the results showed that：Chinese medicine preparation of the present invention is to mouse The indexs such as hair, behavior, stool and urine, weight, organ weights, blood picture, hepatic and renal function, blood glucose, blood fat all have no significant effect, it is dirty After device naked eyes are without finding that abnormal variation and histological indications show medication 16 weeks and be discontinued 4 weeks, the equal nothing of Organs of Mice It substantially change.Illustrate Chinese medicine preparation of the present invention to small toxicity after mouse long-term administration, also without abnormal reaction after drug withdrawal, using peace Entirely.

Long term toxicity test：By the embodiment of the present invention 1 honey refining pill to mouse by 6.43,15.72 and 36.41g crude drugs/ Kg continuous uses 16 weeks (1.0ml/100g weight, 2 times a day) and be discontinued 4 weeks after, the results showed that：Chinese medicine preparation of the present invention is to small The indexs such as hair, behavior, stool and urine, weight, organ weights, blood picture, hepatic and renal function, blood glucose, the blood fat of mouse all have no significant effect, After internal organs naked eyes are without finding that abnormal variation and histological indications show medication 16 weeks and be discontinued 4 weeks, Organs of Mice is equal Nothing is substantially change.Illustrate Chinese medicine preparation of the present invention to small toxicity after mouse long-term administration, also without abnormal reaction, application after drug withdrawal Safety.

Clinical data：

Case selection：Anthology institute flaming-up of the liverfire type hypertensive patient man 103, female 97, age distribution:26-65 Sui. It is randomly divided into four groups：

Mi Lian pills treatment group：50 people, male 25 people, 25 people of female；27~64 years old age, average (51.33 ± 6.35) Year, the course of disease (5.60 ± 4.35) year merge coronary heart disease 18, hyperlipidemia 20, diabetes 12;

Granules in Treating group：50 people, male 26 people, 24 people of female；26~63 years old age, average (52.03 ± 7. 05) year, Merge coronary heart disease 20, hyperlipidemia 18, diabetes 12 in the course of disease (5.70 ± 4.15) year;

Treatment group containing tablet：50 people, male 26 people, 24 people of female；28~63 years old age average (51.22 ± 6. 77) year, Merge coronary heart disease 19, hyperlipidemia 21, diabetes 10 in the course of disease (5.40 ± 4.60) year.

Western medicine group:50 people, male 26 people, 24 people of female, 28~65 years old age, average (51.82 ± 7. 17) year, Merge coronary heart disease 20, hyperlipidemia 20, diabetes 10 in the course of disease (5. 40 ± 4.55) year.

Four groups in not statistically significant (the P &gt of gender, age, the course of disease, body mass index and complication etc. difference; 0. 05) it, is comparable.

Diagnostic criteria：

The diagnosis of high blood pressure is with reference to the Evaluation of Diagnostic Criteria of Hypertension of WHO/ISH, Chinese medical discrimination reference《New Chinese medicine is treated High blood pressure guideline of clinical investigations》The CM syndrome differentiation criterion of syndrome of liver fire flaring up.

Therapy：

Mi Lian pills treatment group：Using the embodiment of the present invention 1 prepare honey refining pill, 2 times a day, one time 4, every 10 days It is as a treatment course;

Granules in Treating group：The granule prepared using the embodiment of the present invention 2,2 times a day, a 15g, every 10 days are one The course for the treatment of;

Treatment group containing tablet：Using the embodiment of the present invention 3 prepare contain tablet, 2 times a day, one time 4, every 10 days be one The course for the treatment of;

Control group：Bezoar pill for lowering blood pressure is taken, Darentang Traditional Chinese Medicine Factory, Tianjin's production weighs 1. 6g, every time 2 ball per ball, Daily 2 or 3 times, per 10 days as one therapeutic course.

Other drugs for hypertension and measure must not be used during four groups of medications.

The standard of curative effect evaluation：

Criterion of therapeutical effect with《Chinese medical disease Standardization of diagnosis and curative effect》The Chinese hypertension prevention and control guide announced with 2004 is new Standard is foundation.

It is effective:The mmHg of systolic pressure/diastolic pressure≤130/85 is not used other depressor, continues not rebound for 3 months, Meanwhile other adjoint clinical symptoms disappear or mitigate, life is fully able to take care of oneself;

Effectively:Hypertension is by II grade or more control in I grade hyperpietics (except original I grades of hypertension case), contraction Pressure/diastolic pressure control is not used other depressor, continues not rebound for 3 months in 135/85 mmHg-150/90 mmHg, Meanwhile other adjoint clinical symptoms disappear or mitigate, life is fully able to take care of oneself;

In vain:Hypertension is through treating still in II grade or more person, the mmHg of systolic pressure/diastolic pressure >=160/100, other companions It is not improved with clinical symptoms.

Treatment results：

Referring to Tables 1 and 2, as it can be seen from table 1 Chinese medicine using the present invention treats flaming-up of the liverfire type hypertension, relatively In Western medicine in therapeutic effect, there is significant improvement；From table 2 it can be seen that Chinese medicine using the present invention treats liver-fire flaming Type hypertension significantly shortens relative to Western medicine in treatment course.

Clinical efficacy comparison example after 1 four groups of table is treated 30 days respectively

Group	Number of cases	It is effective	Effectively	In vain	It is effective and efficient
						Mi Lian pills treatment group	50	31	18	1	98.0%
Granules in Treating group	50	30	18	2	96.0%
						Treatment group containing tablet	50	29	19	2	96.0%
Control group	50	12	20	18	64.0%

2 four groups of table effective and efficiently individual quantity and time comparative example (%) after treating respectively 30 days

Group	Number of cases	The 1-10 days	The 11-20 days	The 21-30 days
					Mi Lian pills treatment group	49	9(18.4%)	24(49.0%)	16(32.7%)
Granules in Treating group	48	10(20.8%)	23(47.9%)	15(31.3%)
					Treatment group containing tablet	48	10(20.8%)	22(45.8%)	16(33.3%)
Control group	32	3(9.4%)	12(37.5%)	17(53.1%)

According to the clinical statistics in above table it is found that Chinese medicine provided by the invention has rapid-action, high efficiency, curative effect Definitely, advantage that is safe, having no toxic side effect；Effective and 49 effective to honey refining pill simultaneously, Granules in Treating group is aobvious Effect and effective 48, treatment group containing tablet effective and effective 48 and effective and effective 32 follow-up of patients of control group It 1 year, as a result counts：

Honey refining pill is effective and 49 effective, effective 31 1 case relapseds, 1 case relapsed in effective 18 patients, multiple Hair rate is 4.1%；

Granules in Treating group is effective and 48 effective, effective 30 1 case relapseds, recurs 1 in effective 18 patients Example, recurrence rate 4.2%；

Treatment group containing tablet is effective and 48 effective, effective 29 1 case relapseds, recurs 1 in effective 19 patients Example, recurrence rate 4.2%；

Western medicine group is effective and 32 effective, and effective 12 recur 2, recur 4 in effective 20 patients, Recurrence rate is 18.8%.

Model case：Zhang, man, 55 years old.In August, 2013 is medical.Patient's readme more than 10 years of hypertension history, once The drugs such as clothes decompression, blood pressure still continue in 140/95 mmHg-160/110mmHg;Feel headache and dizzy, red eyes and bitter taste in the mouth, chest Distending pain is coerced, is insomnia, irritable, urine is yellow, dry and hard excrement, and symptom gradually aggravated over the past two years, red tongue with yellowish fur, wiry and frequent pulse.The heart Electrograph reports that left ventricular hypertrophy, X Pian Shi hearts circle expand to the left.It is diagnosed as hypertension, Chinese medical discrimination flaming-up of the liverfire type.It takes The honey refining pill of Chinese medicine preparation embodiment 1 of the present invention, daily 1 dose, even served 2 courses for the treatment of, blood pressure declines, and all symptoms disappear. It is advised to continue 1 course for the treatment of of taking medicine, further consultation after 2 months, blood pressure stabilization is in 120/80 mmHg, follow-up 1 year, all disease no relapse.

The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all the present invention spirit and Within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.

Claims

1. a kind of Chinese medicine for treating flaming-up of the liverfire type hypertension, which is characterized in that the parts by weight of each raw medicinal material in the Chinese medicine Counting ratio is：15~30 parts of Prunella vulgaris, 13~27 parts of cassia seed, 11~25 parts of butterflybush flower, 22~36 parts of pipewort, the seed of feather cockscomb 23~ 38 parts, 12~24 parts of rough gentian, 16~29 parts of wild chrysanthemum, 30~40 parts of adder-wort, 16~27 parts of pueraria lobata, 18~33 parts of bark of ash, the root of fangji 15~31 parts, 20~35 18~33 parts of Fen, Common St.Paulswort Herbs of ramulus mori, 10~25 parts of clerodendron trichotomum, 13~29 parts of luffa, rhizoma dioscoreae nipponicae 12~ 25 parts, 13~29 parts of Ramulus Taxilli, 18~30 parts of keel, 12~28 parts of mother-of-pearl, 11~26 parts of concha mauritiae, bluish dogbane 20~35 Part, 10~22 parts of uncaria, 15~28 parts of stiff silkworm, 7~18 parts of indigo naturalis, 15~30 23~36 parts of Fen, le three-coloured amaranth of infected foxtail millet spike bran and vertical basin 14~27 parts of grass.

2. Chinese medicine as described in claim 1, which is characterized in that the weight part ratio of each raw medicinal material is in the Chinese medicine：Summer 18~28 parts of withered grass, 15~23 parts of cassia seed, 13~22 parts of butterflybush flower, 25~31 parts of pipewort, 23~30 parts of the seed of feather cockscomb, rough gentian 14~22 parts, 17~26 parts of wild chrysanthemum, 30~38 parts of adder-wort, 17~25 parts of pueraria lobata, 19~31 parts of bark of ash, 16~28 parts of the root of fangji, 23~32 19~32 parts of Fen, Common St.Paulswort Herbs of ramulus mori, 11~24 parts of clerodendron trichotomum, 14~25 parts of luffa, 14~24 parts of rhizoma dioscoreae nipponicae, mulberry are posted 16~28 parts raw, 19~26 parts of keel, 14~23 parts of mother-of-pearl, 12~23 parts of concha mauritiae, 24~35 parts of bluish dogbane, uncaria 11~ 15~25 parts of 21 parts, 17~25 parts of stiff silkworm, 7~14 parts of indigo naturalis, 15~25 23~33 parts of Fen, le three-coloured amaranth of infected foxtail millet spike bran and stringy stonecrop.

3. Chinese medicine as claimed in claim 1 or 2, which is characterized in that the weight part ratio of each raw medicinal material is in the Chinese medicine： 18 parts of Prunella vulgaris, 17 parts of cassia seed, 22 parts of butterflybush flower, 28 parts of pipewort, 23 parts of the seed of feather cockscomb, 19 parts of rough gentian, 23 parts of wild chrysanthemum, fist Ginseng 35 parts, 25 parts of pueraria lobata, 31 parts of bark of ash, 28 parts of the root of fangji, 30 19 parts of Fen, Common St.Paulswort Herbs of ramulus mori, 13 parts of clerodendron trichotomum, 25 parts of luffa, 19 parts of rhizoma dioscoreae nipponicae, 16 parts of Ramulus Taxilli, 26 parts of keel, 17 parts of mother-of-pearl, 21 parts of concha mauritiae, 35 parts of bluish dogbane, 19 parts of uncaria, stiff silkworm 15 parts of 17 parts, 14 parts of indigo naturalis, 22 26 parts of Fen, le three-coloured amaranth of infected foxtail millet spike bran and stringy stonecrop.

4. Chinese medicine as claimed in claim 1 or 2, which is characterized in that the weight part ratio of each raw medicinal material is in the Chinese medicine： 28 parts of Prunella vulgaris, 23 parts of cassia seed, 13 parts of butterflybush flower, 31 parts of pipewort, 30 parts of the seed of feather cockscomb, 22 parts of rough gentian, 17 parts of wild chrysanthemum, fist Ginseng 38 parts, 17 parts of pueraria lobata, 26 parts of bark of ash, 16 parts of the root of fangji, 32 32 parts of Fen, Common St.Paulswort Herbs of ramulus mori, 24 parts of clerodendron trichotomum, 20 parts of luffa, 14 parts of rhizoma dioscoreae nipponicae, 28 parts of Ramulus Taxilli, 19 parts of keel, 23 parts of mother-of-pearl, 12 parts of concha mauritiae, 24 parts of bluish dogbane, 21 parts of uncaria, stiff silkworm 25 parts of 25 parts, 8 parts of indigo naturalis, 15 23 parts of Fen, le three-coloured amaranth of infected foxtail millet spike bran and stringy stonecrop.

5. Chinese medicine as claimed in claim 1 or 2, which is characterized in that the weight part ratio of each raw medicinal material is in the Chinese medicine： 20 parts of Prunella vulgaris, 15 parts of cassia seed, 19 parts of butterflybush flower, 25 parts of pipewort, 29 parts of the seed of feather cockscomb, 14 parts of rough gentian, 26 parts of wild chrysanthemum, fist Ginseng 30 parts, 21 parts of pueraria lobata, 19 parts of bark of ash, 22 parts of the root of fangji, 23 23 parts of Fen, Common St.Paulswort Herbs of ramulus mori, 11 parts of clerodendron trichotomum, 14 parts of luffa, 24 parts of rhizoma dioscoreae nipponicae, 27 parts of Ramulus Taxilli, 25 parts of keel, 14 parts of mother-of-pearl, 23 parts of concha mauritiae, 32 parts of bluish dogbane, 11 parts of uncaria, stiff silkworm 21 parts of 19 parts, 7 parts of indigo naturalis, 25 33 parts of Fen, le three-coloured amaranth of infected foxtail millet spike bran and stringy stonecrop.

6. Chinese medicine according to any one of claims 1 to 5, which is characterized in that when the dosage form of the Chinese medicine is honey refining pill, system Preparation Method includes the following steps：

Step 1：First by Prunella vulgaris, cassia seed, butterflybush flower, pipewort, the seed of feather cockscomb, rough gentian, wild chrysanthemum, adder-wort and pueraria lobata by described Ratio mixes, and distillation crystallizes to obtain powder；

Step 2：It takes surplus stock medicinal material to be mixed in the ratio again, adds relative to 2-6 times of 83-94% ethyl alcohol leaching measured of mixture Bubble 1-2 hour, heating extraction 2 times, 1-1.5 hour each, merging extracting solution, 124-150 mesh filter, then are through the molecular weight that shuts off The ultrafiltration column ultrafiltration of 4400-98000, the medicinal extract that relative density is 1.04 when ultrafiltrate is concentrated under reduced pressure into 87 DEG C, becomes component 1；

Step 3：Adding 4-6 times to measure water step 2 Chinese medicine slag to impregnate 1-2.5 hours, extract 1 time, extraction time is 1.5-2 hours, Thickening filtration is medicinal extract shape, is component 2；

Step 4：2 two kinds of medicinal extract of said components 1 and component are condensed into paste, in addition the powder that step 1 obtains, adds honey to be twisted into Pill.

7. Chinese medicine according to any one of claims 1 to 5, which is characterized in that when the dosage form of the Chinese medicine is granule, prepare Method includes the following steps：

Step 1：The raw medicinal material is mixed in the ratio, add the determining alcohol relative to 4~8 times of mixture be 85%~ 95% ethyl alcohol is heated to boiling reflux 3~5 hours, filtering, uses percolation with the speed of 1~2ml per minute slowly diacolation, Collect percolate, when being then concentrated under reduced pressure into 50~60 DEG C at 0.06~0.09Mpa of vacuum degree relative density be 1.04~ 1.10 lotion, spray drying, 80~85 DEG C of 160~175 DEG C of the inlet air temperature of spray dryer, leaving air temp then crush At powder, dried cream powder is made；

Step 2：The cane sugar powder relative to 0.2~0.4 times of dried cream powder quality and 0.1~0.2 times are added in the dried cream powder of acquisition Dextrin, particle is made, in 40~50 DEG C of dryings, obtains granule.

8. a kind of preparation method of any Chinese medicines of claim 1-5, which is characterized in that the dosage form of the Chinese medicine is lozenge Agent, preparation method includes the following steps：

The first step is mixed Prunella vulgaris, cassia seed, butterflybush flower, pipewort, the seed of feather cockscomb, rough gentian and wild chrysanthemum in the ratio, is used The ethyl alcohol of 4~6 times of determining alcohol 90%~95% of the mixture quality relative to acquisition impregnates, and is carried after being heated to reflux 2~4 hours It takes, filters；Filter residue is impregnated with the ethyl alcohol of 2~4 times of determining alcohol 85%~95% of the mixture quality relative to acquisition again, It extracts, filters after being heated to reflux 1~2 hour；Merge filtered fluid twice, it is 0.8 that ethyl alcohol, which is recovered under reduced pressure, and is concentrated into liquor strength ~1.2g crude drugs/mL, twice using the large pore resin absorption column elution that volume is 5L, first with the deionization of 5 times of resin column volumes Water or distillation water elution, then with the determining alcohols of 3 times of resin column volumes be 90%~95% ethanol elution, collection ethanol eluate subtracts Pressure concentration removes ethyl alcohol, and drying is simultaneously ground into powder；

Adder-wort, pueraria lobata, bark of ash, the root of fangji, ramulus mori, Common St.Paulswort Herbs, clerodendron trichotomum and luffa are mixed in the ratio, are added by second step The ethyl alcohol heating and refluxing extraction of 3~5 times of determining alcohol 85%~95% of the mixture quality relative to acquisition 2 times, is extracted twice Liquid merges, and is centrifuged and is cleaned with tube centrifuge, the extracting solution after removal of impurities is concentrated under reduced pressure into 60 under conditions of 60 DEG C~70 DEG C DEG C when relative density be 1.20~1.23 lotion, the lotion after concentration is dried to powder with spray dryer；

Third walks, and surplus stock medicinal material is mixed in the ratio, adds 2~5 times of water of the mixture quality relative to acquisition It impregnates, heating decocts 2~4 hours, filtering；By filter residue again with 1~3 times of water logging of the mixture quality relative to acquisition Bubble, heating decoct 1~2 hour, filtering；Merge filtered fluid twice, be concentrated under reduced pressure and remove moisture, drying is simultaneously ground into powder；

4th step, the powder that the first step, second step and third step obtain is mixed, and the mixture relative to acquisition is further added After dry, phase is added in the sodium carboxymethyl starch that 0.05~0.1 times of quality, 0.05~0.1 times of microcrystalline cellulose, mixing, granulation For the magnesium stearate of 0.01~0.05 times of the mixture quality of acquisition, then with decompressor by particle it is tabletted to get Containing tablet.