CN101584796B - Application of traditional Chinese medicine composition in preparing medicament for treating melancholia - Google Patents
Application of traditional Chinese medicine composition in preparing medicament for treating melancholia Download PDFInfo
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Abstract
The invention discloses application of a traditional Chinese medicine composition in preparing a medicament for treating melancholia. The traditional Chinese medicine composition contains rehmannia, frutus cnidii, and the like; through clinical and animal experimentations, the medicament can treat melancholia with stable safety, obvious effect and little side effect, and is suitable for the clinical application.
Description
Technical field
The present invention relates to the application of a kind of Chinese medicine composition in preparation treatment depression medicine, belong to the Chinese herbal and crude drugs preparations technical field.
Background technology
Depression is to perplex human a kind of spirit, psychological illness since ancient times always, and its history is quite remote, and the clinical description relevant with depression is shown in " left side biography " of Qin period the earliest.Generally speaking, it is the mental sickness of basic clinical with the remarkable and persistent change of mental state (soar or low) that depression is one group, often with corresponding thinking and behavior change.Generally be acute or subacute onset, the tendency of outbreak is arranged repeatedly, most patients is alleviated thoroughly, 15%～20% patient is in chronic, minor psychosis state, and social function can not return to the preceding level of disease.Be the center symptom with depressed clinically, show as pessimism, to daily routines forfeitures interest and happy sense, energy obviously goes down, the lasting tired sense of no obvious cause, severe patient even occur suicidal thought or behavior repeatedly.This type of patient's head CT, MRI check generally normal, and minority shows as ventricles of the brain expansion, the broadening of brain ditch, cerebellar atrophy; Sleep electroencephalogram can have following change, the total sleep time minimizing, and the awakening increased frequency, the moving sleep of being sharp-eyed shortened (REN) incubation period, and non-REN the 1st phase of sleeping increases, 3,4 phases minimizing etc.Visible clinically polytype is like reactive depression, postpartum depression, apoplexy retarded depression disease, teenager depression etc.Along with the variation of human diseases spectrum and the change of rule of life, the sickness rate of depression raises year by year, is called as " flu " of psychiatric department, becomes one of modal disease of psychiatric system, serious human beings'health and the life of threatening.(the Chinese and western medicine opinion of depression is controlled research overview. Wang Xiaoling, Li Cuiyun. and the Inner Mongol Chinese medicine .2007 first phase)
About the cause of disease of depression, basically, still can not thoroughly illustrate at present, but many theories are arranged.In a broad sense, two kinds of different causes of disease of biogenic property and psychological source property are arranged.Western medicine is mainly leaned at present clinical treatment to depression, though clinical efficacy is preferably arranged, untoward reaction and drug withdrawal syndrome is arranged generally; Chinese medicine has many therapies such as determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, specific prescription and medication, acupuncture at the treatment depression, has certain potentiality and advantage, thus be really to reach " treating both the principal and secondary aspects of a disease " with the Chinese medicine depression, the good method of raising curative effect.
The traditional Chinese medical science just has argumentation in the advantage of treatment aspect the depression in " interior warp ", like " anxious melancholy person, gas-tight plug and not all right ", propose the method for treatment of " soothing the stagnant liver, dispersing fire for treating depression of fire, dampness accumulated in the spleen should be removed, Jin Yu are rushed down it, retention of fluid being treated with draining method " then; Zhu Danxi thinks and " QI and blood dash with, ten thousand diseases are not given birth to, and have looking angry strongly fragrantly, all diease occurrences are here " proposes " six kinds of stagnation-syndromes " theory thus; It is cloudy that the traditional Chinese medical science it is generally acknowledged that depressive psychosis belongs to, and many deficiency syndrome, the rule of treatment are suitable for tonify deficiency to be set upright, mind tranquilizing and the heart calming, and tonifying YANG is excited, the regulating YIN and YANG balance.(the Chinese and western medicine opinion of depression is controlled research overview. Wang Xiaoling, Li Cuiyun. and the Inner Mongol Chinese medicine .2007 first phase)
The present invention is the improvement invention of on the basis of 02146569.X patent, carrying out, and quotes in full the content of this patent document record at this.The application of unexposed this Chinese medicine composition of above-mentioned patent in the treatment depression.
Summary of the invention
The present invention relates to a kind of new purposes of Chinese medicine composition, particularly, relate to the application of a kind of Chinese medicine composition in preparation treatment depression medicine.Chinese medicine according to the invention can be had the Chinese medicine of same or similar effect to replace, and these medical materials all can be concocted according to " national Chinese medicine processing standard " or " Chinese medicine voluminous dictionary ".
The active component of the Chinese medicine preparation of treatment depression disclosed by the invention is processed by the following weight ratio formula material:
Semen Cuscutae 150-350 Fructus Lycii 100-200 Fructus Schisandrae Chinensis 30-60 Fructus Cnidii 20-50
Fructus Rosae Laevigatae 20-50 Fructus Rubi 20-50 Semen Allii Tuberosi 20-50 Radix Morindae Officinalis 20-50
Herba Cistanches 20-50 Radix Rehmanniae 30-60 Radix Cyathulae 20-50 Herba Epimedii 40-100
Radix Ginseng 15-35 Cornu Cervi Pantotrichum 10-25 Hippocampus 10-30 Fructus Toosendan 15-35.
The weight ratio of crude drug is preferably in the Chinese medicine composition of the present invention:
20 parts of 60 parts of Fructus Cnidiis of 100 parts of Fructus Schisandrae Chinensis of 350 parts of Fructus Lycii of Semen Cuscutae
20 parts of 50 parts of Radix Morindae Officinaliss of 20 parts of Semen Allii Tuberosi of 50 portions of Fructus Rubies of Fructus Rosae Laevigatae
40 parts of 50 parts of Herba Epimedii of 30 portions of Radix Cyathulaes of 50 portions of Radix Rehmanniae of Herba Cistanches
15 parts of 0 part of Fructus Toosendans of 10 parts of hippocampus 3s of 35 parts of Cornu Cervi Pantotrichums of Radix Ginseng.
Or:
46 parts of 70 parts of Fructus Schisandrae Chinensis of 138 parts of Herba Epimedii of 250 parts of Fructus Lycii of Semen Cuscutae
35 parts of 35 parts of Semen Allii Tuberosi of 35 portions of Fructus Rubies of 35 portions of Fructus Rosae Laevigatae of Fructus Cnidii
35 parts of 46 portions of Radix Cyathulaes of 35 portions of Radix Rehmanniae of 35 parts of Herba Cistanches of Radix Morindae Officinalis
23 parts of 21 parts of Fructus Toosendans of 16 portions of Hippocampus of 25 parts of Cornu Cervi Pantotrichums of Radix Ginseng.
Or:
50 parts of 30 parts of Fructus Cnidiis of 200 parts of Fructus Schisandrae Chinensis of 150 parts of Fructus Lycii of Semen Cuscutae
50 parts of 20 parts of Radix Morindae Officinaliss of 50 parts of Semen Allii Tuberosi of 20 portions of Fructus Rubies of Fructus Rosae Laevigatae
100 parts of 20 parts of Herba Epimedii of 60 portions of Radix Cyathulaes of 20 portions of Radix Rehmanniae of Herba Cistanches
35 parts of 10 parts of Fructus Toosendans of 25 portions of Hippocampus of 15 parts of Cornu Cervi Pantotrichums of Radix Ginseng.
The pharmaceutical composition of described treatment depression, its form also can comprise the Radix Astragali, Radix Scrophulariae, the Cortex Eucommiae, Solenognathus, Cordyceps, Testis et penis callorhini, Endoconcha Sepiae, Ootheca Mantidis, Semen Euryales, Rhizoma Dioscoreae, Radix Dipsaci, Radix Rehmanniae Preparata, Semen Nelumbinis wherein one or more.
The preparation of drug combination method of above-mentioned treatment depression comprises:
A, take by weighing Chinese crude drug, clean according to the crude drug part by weight;
B, get Fructus Cnidii, Semen Cuscutae, Fructus Schisandrae Chinensis, Herba Epimedii and add 6-10 and doubly measure 60-80% ethanol, reflux, extract, 1-3 time, each 1-3 hour, filter, collecting decoction, decompression recycling ethanol is to there not being the alcohol flavor, and is subsequent use;
Medical material residue and merging after c, Fructus Lycii, Radix Rehmanniae, Fructus Rubi, Fructus Rosae Laevigatae, Semen Allii Tuberosi, Radix Morindae Officinalis, Fructus Toosendan and the alcohol extraction; Add water 6-10 and doubly measure decoction 1-3 time; Each 1-3 hour, filter merging filtrate; Mix with step (b) gained alcohol extract, measuring relative density during 60 ℃ of simmer down tos is the clear paste of 1.25-1.30;
D, Radix Ginseng, Cornu Cervi Pantotrichum, Hippocampus, Herba Cistanches, Radix Cyathulae are ground into fine powder;
Step c gained clear paste and steps d gained fine powder constitute the active component of Chinese medicine composition of the present invention jointly.
The preparation of drug combination method step (c) of described treatment depression, the mixture that (d) processes can be used for preparing clinically the base stock of tablet, electuary, powder.
Other dosage forms of medicine of the present invention are in proportion after the weighting raw materials; Adopt conventional method for preparing preparation; For example, the preparation technology of Fan Biting " pharmacy of Chinese materia medica " (Shanghai Science Press 1997 December the 1st edition) record processes the acceptable regular dosage form of pharmaceutics.
For above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, PEG4000, insect wax etc.For making above-mentioned dosage form can realize pharmacy of Chinese materia medica, need when these dosage forms of preparation, to add acceptable other adjuvant of pharmacy (adjuvant of each dosage form record among the Fan Biting " pharmacy of Chinese materia medica ", Shanghai Science Press December in 1997 the 1st edition).
Dosage form of the present invention is capsule, tablet, powder, oral liquid, soft capsule, pill, tincture, syrup, suppository, gel, spray or injection.
Preferably, the method for preparing of capsule of the present invention is:
A, take by weighing Chinese crude drug, clean according to the crude drug part by weight;
B, get Fructus Cnidii, Semen Cuscutae, Fructus Schisandrae Chinensis, Herba Epimedii and add 6-10 and doubly measure 60-80% ethanol, reflux, extract, 1-3 time, each 1-3 hour, filter, collecting decoction, decompression recycling ethanol is to there not being the alcohol flavor;
Medical material residue and merging after c, Fructus Lycii, Radix Rehmanniae, Fructus Rubi, Fructus Rosae Laevigatae, Semen Allii Tuberosi, Radix Morindae Officinalis, Fructus Toosendan and the alcohol extraction; Add water 6-10 and doubly measure decoction 1-3 time; Each 1-3 hour, filter merging filtrate; Mix with step (b) gained alcohol extract, measuring relative density during 60 ℃ of simmer down tos is the clear paste of 1.25-1.30;
D, Radix Ginseng, Cornu Cervi Pantotrichum, Hippocampus, Herba Cistanches, Radix Cyathulae are ground into fine powder;
E, with steps d gained fine powder and step c gained clear paste mixing and stirring, oven dry is pulverized, and incapsulates, and promptly gets.
The invention provides the application of a kind of Chinese medicine composition in preparation treatment depression medicine, preferably, said depression is a depression in old age.
For confirming Drug therapy curative effect of depression of the present invention, use the capsule (to call medicine of the present invention in the following text) that makes by embodiment, carried out following clinical experimental study:
The specific embodiment
Following embodiment is used to illustrate the preparation of Chinese medicine composition of the present invention, but it can not constitute any restriction to scope of the present invention.
Embodiment 1:
Semen Cuscutae 250g Fructus Lycii 138g Herba Epimedii 70g Fructus Schisandrae Chinensis 46g
Fructus Cnidii 35g Fructus Rosae Laevigatae 35g Fructus Rubi 35g Semen Allii Tuberosi 35g
Radix Morindae Officinalis 35g Herba Cistanches 35g Radix Rehmanniae 46g Radix Cyathulae 35g
Radix Ginseng 25g Cornu Cervi Pantotrichum 16g Hippocampus 21g Fructus Toosendan 23g
Method for preparing:
(1), get Fructus Cnidii 35g, Semen Cuscutae 250g, Fructus Schisandrae Chinensis 46g, Herba Epimedii 70g, add 8 times of amount 70% ethanol, reflux, extract, 2 times, each 2 hours, filter, collecting decoction, decompression recycling ethanol is not to there being the alcohol flavor, residue is subsequent use;
(2), the medical material residue after the alcohol extraction and Fructus Lycii 138g, Radix Rehmanniae 46g, Fructus Rubi 35g, Fructus Rosae Laevigatae 35g, Semen Allii Tuberosi 35g, Radix Morindae Officinalis 35g, Fructus Toosendan 23g are merged; Adding 9 times of amounts of water decocts twice; Each 2 hours, filter merging filtrate; Mix with step (1) alcohol extract, be evaporated to the clear paste of relative density 1.25-1.30 (60 ℃);
(3), Radix Ginseng 25g, Cornu Cervi Pantotrichum 16g, Hippocampus 21g, Herba Cistanches 35g, Radix Cyathulae 35g be ground into fine powder, with above-mentioned clear paste mix homogeneously, 65-70 ℃ of oven dry, pulverizes, and sieves, encapsulatedly promptly get.
Oral, one time 2,3 times on the one.
Embodiment 2,
Semen Cuscutae 350g Fructus Lycii 100g Fructus Schisandrae Chinensis 60g Fructus Cnidii 20g
Fructus Rosae Laevigatae 50g Fructus Rubi 20g Semen Allii Tuberosi 50g Radix Morindae Officinalis 20g
Herba Cistanches 50g Radix Rehmanniae 30g Radix Cyathulae 50g Herba Epimedii 40g
Radix Ginseng 35g Cornu Cervi Pantotrichum 10g hippocampus 3 0g Fructus Toosendan 15g.
Method for preparing:
(1), take by weighing Chinese crude drug, clean according to the crude drug part by weight;
(2), get Fructus Cnidii, Semen Cuscutae, Fructus Schisandrae Chinensis, Herba Epimedii, add 6 times of amount 60% ethanol, reflux, extract, 1 time, 3 hours, filter, collecting decoction, decompression recycling ethanol is not to there being the alcohol flavor, residue is subsequent use;
(3), the medical material residue after the alcohol extraction and Fructus Lycii, Radix Rehmanniae, Fructus Rubi, Fructus Rosae Laevigatae, Semen Allii Tuberosi, Radix Morindae Officinalis, Fructus Toosendan are merged; Adding 6 times of amounts of water decocts 1 time; 3 hours, filter merging filtrate; Mix with step (1) alcohol extract, be evaporated to the clear paste of relative density 1.25-1.30 (60 ℃);
(4), Radix Ginseng, Cornu Cervi Pantotrichum, Hippocampus, Herba Cistanches, Radix Cyathulae be ground into fine powder, with above-mentioned clear paste mix homogeneously, 65-70 ℃ of oven dry, pulverizes, and sieves, and processes tablet by the conventional formulation method.
Embodiment 3,
Semen Cuscutae 150g Fructus Lycii 200g Fructus Schisandrae Chinensis 30g Fructus Cnidii 50g
Fructus Rosae Laevigatae 20g Fructus Rubi 50g Semen Allii Tuberosi 20g Radix Morindae Officinalis 50g
Herba Cistanches 20g Radix Rehmanniae 60g Radix Cyathulae 20g Herba Epimedii 100g
Radix Ginseng 15g Cornu Cervi Pantotrichum 25g Hippocampus 10g Fructus Toosendan 35g.
Method for preparing:
(1), take by weighing Chinese crude drug, clean according to the crude drug part by weight;
(2), get Fructus Cnidii, Semen Cuscutae, Fructus Schisandrae Chinensis, Herba Epimedii, add 10 times of amount 80% ethanol, reflux, extract, 3 times, each 2 hours, filter, collecting decoction, decompression recycling ethanol is not to there being the alcohol flavor, residue is subsequent use;
(3), the medical material residue after the alcohol extraction and Fructus Lycii, Radix Rehmanniae, Fructus Rubi, Fructus Rosae Laevigatae, Semen Allii Tuberosi, Radix Morindae Officinalis, Fructus Toosendan are merged; Adding 10 times of amounts of water decocts 3 times; Each 1 hour, filter merging filtrate; Mix with step (1) alcohol extract, be evaporated to the clear paste of relative density 1.25-1.30 (60 ℃);
(4), Radix Ginseng, Cornu Cervi Pantotrichum, Hippocampus, Herba Cistanches, Radix Cyathulae be ground into fine powder, with above-mentioned clear paste mix homogeneously, 65-70 ℃ of oven dry processed pill by the conventional formulation method.
Embodiment 4:
Medicine composite for curing depression of the present invention clinical trial
For illustrating the activity of traditional Chinese medicine composition for treating climacteric syndrome of the present invention, use the capsule (to call medicine of the present invention in the following text) that makes by the foregoing description 1 method to carry out following clinical trial.
1. material and method
1.1 object of study
In July, 2006～2008 year January, select to adopt medicine composite for curing depression of the present invention, satisfactory effect, and with the routine of western medicine treatment for comparing existing the report as follows:
It is attached to mountain range hospital outpatient prescription on individual diagnosis patient that clinical data 82 routine patients are Hebei Medical University, and be divided into two groups at random: 41 examples are organized in treatment, wherein male 18 examples; Woman's 23 examples, 17～72 years old age, average (36 ± 9) year; The course of disease 1 year～3 years, Hamilton depressive scale scoring: 24.2 ± 2.4 minutes; Matched group 41 examples, wherein male 17 examples, women 24 examples, age 18-69 year, the course of disease 1 year～3 years, Hamilton depressive scale scoring: 23.8 ± 2.1 minutes; Two groups of patient's sexes, age, the course of disease, Hamilton depressive scales scoring data such as [1], through statistical procedures, zero difference (P＞0.05) has comparability.
Case selected condition (1) is diagnosed as the patient of depression according to the diagnostic criteria [2] of " Chinese mental sickness classification and diagnostic criteria " the 3rd edition (CCMD-3); (2) vital sign is steady, and sanity can be understood the SDS content, has certain ability to express, ability partner treatment person; The person that do not take the antidepressant drug in (3) 2 weeks; (4) differential diagnosis in tcm belongs to hepatic and renal YIN deficiency person.(disease is seen: be in a very depressed state and/or hebetude insomnia and dreamful sleep, soreness of the waist and knees, dysphoria with feverish sensation in the chest palms and soles, dizziness and tinnitus, red tongue with thin fur, thready pulse etc.).
1.2 Therapeutic Method
Therapeutic Method treatment group gives 2 of pharmaceutical compositions of the present invention/inferior, and every day 3 times is oral, matched group with fluoxetine (Lilly invite company limited production; Trade name is a fluoxetine; Every 20mg) initial amount 20mg/d, value added 40mg/d as required, mean dose (22.6 ± 2.25) mg/d.6 weeks of the course of treatment.When going to a doctor, two groups of patients all carried out psychological counseling and necessary humanistic care, other adjuvant drugs of stopping using, and treating 30 days is 1 course of treatment, the evaluation curative effect.
1.3 the evaluation of curative effect
Criterion of therapeutical effect is before treatment and treated for 1,2,4,6 weeks employing Hamilton depressive scale, CGI (CGI) evaluation curative effect.Evaluate untoward reaction in 1,2,4,6 weeks of treatment with side reaction scale (TESS).
Lab testing: carry out inspections such as blood, routine urinalysis, electrocardiogram, liver, renal function when before treatment, reaching for the 6th week, measuring body quality when before treatment, reaching the treatment end.The Kappa value is 0.75-0.88, and HAMD subtracts branch rate >=75% and is recovery from illness, and 50-74% is marked improvement, and 25-49% is for progressive, and＜25% is invalid.
1.4 statistical method
All data of statistical method are carried out t check and x
2Check is that difference has significance with P＜0.05.
2, result
2.1 case wastage in the therapeutic process
Because of a variety of causes causes case loss person: matched group 6 examples (14.5%), treatment are organized 7 examples (16.1%), and 6 weeks were matched group 35 examples (85.5%) when finishing, and treatment is organized 34 examples (82.9%) and accomplished the clinical research treatment.Through x
2Check, two groups of differences do not have significance (P＜0.05).
The SDS scoring relatively before and after two groups of treatments
CGI before and after two groups of treatments
It is relatively preceding with treatment,
*P＜0.01; Two groups with the time relatively: * P＜0.05
Visible by above-mentioned analytic statistics result, dialectical the executing of pharmaceutical composition of the present invention controlled, and tonify deficiency is set upright, mind tranquilizing and the heart calming; Tonifying YANG is excited, and the regulating YIN and YANG balance has good therapeutic effect to depression, and few side effects; The compliance of patient's medication is good, can avoid occurring dizziness simultaneously, feels sick the side effect of clinical applications such as fatigue and weak; Do not see drug dependence, no withdrawal symptom is worth clinical application.
Claims (8)
1. the application of Chinese medicine composition in the medicine of preparation treatment depression is characterized in that it being to be processed by following raw medicaments in portion by weight:
2. application according to claim 1 is characterized in that the weight portion proportioning of the crude drug of said Chinese medicine composition is:
Sub 60 Fructus Cnidiis, 20 Fructus Rosae Laevigatae 50 of Semen Cuscutae 350 Fructus Lycii, 100 flavors
Fructus Rubi 20 Semen Allii Tuberosi 50 Radix Morindae Officinaliss 20 Herba Cistanches 50 Radix Rehmanniae 30
Radix Cyathulae 50 Herba Epimedii 40 Radix Ginsengs 35 Cornu Cervi Pantotrichums 10 hippocampus 3s 0 Fructus Toosendan 15.
3. application according to claim 1 is characterized in that the weight portion proportioning of the crude drug of said Chinese medicine composition is:
Semen Cuscutae 250 Fructus Lycii 138 Herba Epimedii 70 Fructus Schisandrae Chinensis 46 Fructus Cnidiis 35
Fructus Rosae Laevigatae 35 Fructus Rubies 35 Semen Allii Tuberosi 35 Radix Morindae Officinaliss 35 Herba Cistanches 35
Radix Rehmanniae 46 Radix Cyathulaes 35 Radix Ginsengs 25 Cornu Cervi Pantotrichums 16 Hippocampus 21 Fructus Toosendans 23.
4. application according to claim 1 is characterized in that the weight portion proportioning of the crude drug of said Chinese medicine composition is:
Semen Cuscutae 150 Fructus Lycii 200 Fructus Schisandrae Chinensis 30 Fructus Cnidiis 50 Fructus Rosae Laevigatae 20
Fructus Rubi 50 Semen Allii Tuberosi 20 Radix Morindae Officinaliss 50 Herba Cistanches 20 Radix Rehmanniae 60
Radix Cyathulae 20 Herba Epimedii 100 Radix Ginsengs 15 Cornu Cervi Pantotrichums 25 Hippocampus 10 Fructus Toosendans 35.
5. according to each described application of claim 1-4, it is characterized in that the active component of said Chinese medicine composition is processed by following steps:
A, take by weighing Chinese crude drug, clean according to the crude drug part by weight;
B, get Fructus Cnidii, Semen Cuscutae, Fructus Schisandrae Chinensis, Herba Epimedii and add 6-10 and doubly measure 60-80% ethanol, reflux, extract, 1-3 time, each 1-3 hour, filter, collecting decoction, decompression recycling ethanol is to there not being the alcohol flavor, and is subsequent use;
Medical material residue after c, Fructus Lycii, Radix Rehmanniae, Fructus Rubi, Fructus Rosae Laevigatae, Semen Allii Tuberosi, Radix Morindae Officinalis, Fructus Toosendan and the alcohol extraction merges; Add water 6-10 and doubly measure decoction 1-3 time; Each 1-3 hour, filter merging filtrate; Mix with step b gained alcohol extract, measuring relative density during 60 ℃ of simmer down tos is the clear paste of 1.25-1.30;
D, Radix Ginseng, Cornu Cervi Pantotrichum, Hippocampus, Herba Cistanches, Radix Cyathulae are ground into fine powder;
Step c gained clear paste and steps d gained fine powder constitute the active component of said Chinese medicine composition jointly.
6. according to each described application of claim 1-4, it is characterized in that said Chinese medicine composition pharmaceutical dosage form is capsule, tablet, powder, oral liquid, pill, tincture, syrup, suppository, gel, spray or injection.
7. application according to claim 6 is characterized in that said capsule is to be processed by following steps:
A, take by weighing Chinese crude drug, clean according to the crude drug part by weight;
B, get Fructus Cnidii, Semen Cuscutae, Fructus Schisandrae Chinensis, Herba Epimedii and add 6-10 and doubly measure 60-80% ethanol, reflux, extract, 1-3 time, each 1-3 hour, filter, collecting decoction, decompression recycling ethanol is to there not being the alcohol flavor;
Medical material residue after c, Fructus Lycii, Radix Rehmanniae, Fructus Rubi, Fructus Rosae Laevigatae, Semen Allii Tuberosi, Radix Morindae Officinalis, Fructus Toosendan and the alcohol extraction merges; Add water 6-10 and doubly measure decoction 1-3 time; Each 1-3 hour, filter merging filtrate; Mix with step b gained alcohol extract, measuring relative density during 60 ℃ of simmer down tos is the clear paste of 1.25-1.30;
D, Radix Ginseng, Cornu Cervi Pantotrichum, Hippocampus, Herba Cistanches, Radix Cyathulae are ground into fine powder;
E, with steps d gained fine powder and step c gained clear paste mixing and stirring, oven dry is pulverized, and incapsulates, and promptly gets.
8. like each described application among the claim 1-4, it is characterized in that said depression is a depression in old age.
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| CN101940315B (en) * | 2010-09-11 | 2013-05-01 | 海南壹号药业有限公司 | Hippocampus soft capsule and preparation method thereof |
| CN102100745B (en) * | 2011-01-21 | 2012-01-11 | 王静怡 | Oral administration medicament for treating depression |
| CN102327557A (en) * | 2011-09-10 | 2012-01-25 | 田开勇 | Anxiety-removing calming traditional Chinese medicine decoction for treating anxiety neurosis |
| CN103386004B (en) * | 2012-05-12 | 2015-07-22 | 石家庄以岭药业股份有限公司 | Application of traditional Chinese medicinal composition in preparation of anti-ageing medicines |
| CN112316046B (en) * | 2019-08-05 | 2023-04-14 | 石家庄以岭药业股份有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating atherosclerosis |
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