CN102552645A - Formula of kidney-tonifying and yang-strengthening health-care medicament - Google Patents
Formula of kidney-tonifying and yang-strengthening health-care medicament Download PDFInfo
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Abstract
The invention provides a formula of a kidney-tonifying and yang-strengthening health-care medicament, and relates to the field of medicaments. The medicament is prepared by combination of the following components: 6 to 10g of leek extract, 4 to 9g of morinda officinalis, 4 to 9g of cordyceps sinensis, 6 to 12g of cistanche, 4 to 9g of ginseng, 3 to 8g of beta-cyclodextrin, 4 to 10g of pregelatinized starch, 3 to 8g of microcrystalline cellulose, 6 to 15g of powdered sugar, and 0.3 to 1g of magnesium stearate. The preparation process comprises the following steps: respectively crushing the morinda officinalis, the cordyceps sinensis, the cistanche and the ginseng; screening through a 60 to 80-mesh screen; weighing the crushed medicinal powder and other raw and auxiliary materials, and mixing for 45 to 50 minutes; filling into capsules, and controlling the weight of powdered medicaments according to an inner quality standard; separating, polishing, internally packaging and externally packaging; and inspecting according to the inspection standard and putting in a warehouse. The medicament helps people enhancing immunity, relieving physical fatigue and tonifying kidney and strengthening yang, so that the living level of people is improved, the living quality of people is increased, and side effect or adverse reactions cannot be generated; and the product is safe and stable and has controllable quality by using modern preparation technology and advanced quality control method.
Description
Technical field:
The present invention relates to drug world, be specifically related to a kind of prescription of kidney supplementing yang invigorating health care medicine.
Background technology:
Sexual disorder is a kind of complex physical phenomenon of human body, is the result of multifactor comprehensive function.A large amount of research makes people exhaust or the metabolite accumulation from simple material for the understanding of immunity, is deep into cell, subcellular fraction and even molecular level gradually.
Along with the quickening of modern life rhythm, the aggravation of social competition, hypoimmunity more and more becomes the health problem of puzzlement much human, causes that because of hypoimmunity the crowd of disease also increases gradually, and will be in ascendant trend always.Simultaneously, along with growth in the living standard, health perception also strengthens gradually, and the health product with enhancing immunity have the very big market space.
Summary of the invention:
The prescription that the purpose of this invention is to provide a kind of kidney supplementing yang invigorating health care medicine, it can improve people's sexual function, to diseases such as treatment sexual impotence, premature ejaculation, therapeutical effect is arranged, and has the vigor of enhances human body superficial cell simultaneously, suppresses effects such as aging.
In order to solve the existing problem of background technology; The present invention adopts following technical scheme: the prescription ratio of this medicine is leek extract 6-10g, Radix Morindae Officinalis 4-9g, Cordyceps 4-9g, Herba Cistanches 6-12g, Radix Ginseng 4-9g, beta-schardinger dextrin-3-8g, pregelatinized Starch 4-10g, microcrystalline Cellulose 3-8g, Icing Sugar 6-15g, magnesium stearate 0.3-1g.
First preferred implementation of this medicine is that prescription is than being leek extract 6g, Radix Morindae Officinalis 4g, Cordyceps 4g, Herba Cistanches 2g, Radix Ginseng 4g, beta-schardinger dextrin-3g, pregelatinized Starch 4g, microcrystalline Cellulose 3g, Icing Sugar 6g, magnesium stearate 0.3g.
Second preferred implementation of this medicine is that prescription is than being leek extract 10g, Radix Morindae Officinalis 9g, Cordyceps 9g, Herba Cistanches 12g, Radix Ginseng 9g, beta-schardinger dextrin-8g, pregelatinized Starch 10g, microcrystalline Cellulose 8g, Icing Sugar 15g, magnesium stearate 1g.
The 3rd preferred implementation of this medicine does; Prescription is than being leek extract 8g, Radix Morindae Officinalis 6g, Cordyceps 5.5g, Herba Cistanches 7.2g, Radix Ginseng 6.7g, beta-schardinger dextrin-5.6g, pregelatinized Starch 6.4g, microcrystalline Cellulose 5.5g, Icing Sugar 7.8g, magnesium stearate 0.56g.
The effective ingredient of leek extract is a nucleoside; The effective ingredient of Radix Morindae Officinalis extract is that Radix Morindae Officinalis is plain; The effective ingredient of Cordyceps is a Paecilomyces hepiali Chen et Dai Mycelia; The effective ingredient of Herba Cistanches extract is that Herba Cistanches is plain, and the effective ingredient of Radix Ginseng extract is the ginsenoside, and the effective ingredient of beta-schardinger dextrin-is pregelatinized Starch.
The effective ingredient ratio of this medicine is preferably: the 100g medicine contains effective composition nucleoside 1200mg, the plain 4000mg of Radix Morindae Officinalis, Paecilomyces hepiali Chen et Dai Mycelia 700mg, the plain 4500mg of Herba Cistanches, ginsenoside 2000mg.
The method for preparing of this medicine is: earlier Radix Morindae Officinalis, Cordyceps, Herba Cistanches, Radix Ginseng are pulverized respectively; Cross the 60-80 mesh sieve, the various drug powders after weighing is pulverized mix with other supplementary material, incorporation time control 45-50 minute; Carrying out capsule then fills; Filling process is filled the weight of medicated powder according to inner quality standard control, selects, polishing, inner packing, outer package, preferably according to touchstone check warehouse-in again.
The present invention's ability kidney invigorating and YANG supporting can improve people's sexuality, to controlling sexual impotence, the effect of premature ejaculation patient treatment.
The specific embodiment:
This specific embodiment adopts following technical scheme: the prescription ratio of this medicine is leek extract 6-10g, Radix Morindae Officinalis 4-9g, Cordyceps 4-9g, Herba Cistanches 6-12g, Radix Ginseng 4-9g, beta-schardinger dextrin-3-8g, pregelatinized Starch 4-10g, microcrystalline Cellulose 3-8g, Icing Sugar 6-15g, magnesium stearate 0.3-1g.
First preferred implementation of this medicine is that prescription is than being leek extract 6g, Radix Morindae Officinalis 4g, Cordyceps 4g, Herba Cistanches 2g, Radix Ginseng 4g, beta-schardinger dextrin-3g, pregelatinized Starch 4g, microcrystalline Cellulose 3g, Icing Sugar 6g, magnesium stearate 0.3g.
Second preferred implementation of this medicine is that prescription is than being leek extract 10g, Radix Morindae Officinalis 9g, Cordyceps 9g, Herba Cistanches 12g, Radix Ginseng 9g, beta-schardinger dextrin-8g, pregelatinized Starch 10g, microcrystalline Cellulose 8g, Icing Sugar 15g, magnesium stearate 1g.
The 3rd preferred implementation of this medicine does; Prescription is than being leek extract 8g, Radix Morindae Officinalis 6g, Cordyceps 5.5g, Herba Cistanches 7.2g, Radix Ginseng 6.7g, beta-schardinger dextrin-5.6g, pregelatinized Starch 6.4g, microcrystalline Cellulose 5.5g, Icing Sugar 7.8g, magnesium stearate 0.56g.
The effective ingredient of leek extract is a nucleoside; The effective ingredient of Radix Morindae Officinalis extract is that Radix Morindae Officinalis is plain; The effective ingredient of Cordyceps is a Paecilomyces hepiali Chen et Dai Mycelia; The effective ingredient of Herba Cistanches extract is that Herba Cistanches is plain, and the effective ingredient of Radix Ginseng extract is the ginsenoside, and the effective ingredient of beta-schardinger dextrin-is pregelatinized Starch.
The effective ingredient ratio of this medicine is preferably: the 100g medicine contains effective composition nucleoside 1200mg, the plain 4000mg of Radix Morindae Officinalis, Paecilomyces hepiali Chen et Dai Mycelia 700mg, the plain 4500mg of Herba Cistanches, ginsenoside 2000mg.
The method for preparing of this medicine is: earlier Radix Morindae Officinalis, Cordyceps, Herba Cistanches, Radix Ginseng are pulverized respectively; Cross the 60-80 mesh sieve, the various drug powders after weighing is pulverized mix with other supplementary material, incorporation time control 45-50 minute; Carrying out capsule then fills; Filling process is filled the weight of medicated powder according to inner quality standard control, selects, polishing, inner packing, outer package, preferably according to touchstone check warehouse-in again.
The present invention's ability kidney invigorating and YANG supporting improves people's sexual function, to controlling sexual impotence, the effect of premature ejaculation patient treatment.
Leek extract:
Folium Allii tuberosi seed and root all can be used as medicine, and seed is warm in nature, and acrid in the mouth, salty is gone into liver, kidney channel; That chews pungently has a Folium Allii tuberosi flavor, contains alkaloid and saponin, can invigorating the liver and kidney; Warm waist knee joint, Xing Yangdao controls sexual impotence controlling nocturnal emission with astringent drugs and married woman's YIN-cold; Lower abdomen pain is the strong waist medicine of excitement of the strong waist of the kidney invigorating, can be used for treating diseases such as seminal emission, premature ejaculation, sexual impotence and polyuria.According to the pharmacopeia record, the Folium Allii tuberosi seed has the effect of " temperature compensation Liver and kidney, tonifying YANG controlling nocturnal emission with astringent drugs ", and the fragrant-flowered garlic seed is used as strengthening yang and invigorating kidney and is used as medicine in China's history among the people existing thousands of years.
According to the pharmacopeia record, the Folium Allii tuberosi seed has the effect of " temperature compensation Liver and kidney, tonifying YANG controlling nocturnal emission with astringent drugs ", and with being used as medicine in China's existing thousands of years history among the people, China's Ministry of Public Health was classified it as medicine food dual purpose plant natural product to the fragrant-flowered garlic seed in 2002 as strengthening yang and invigorating kidney.In the Allium tubersum rottl extract there be main component: tabacin, β 2 daucosterols contain ribosidoadenine, thymidine especially, for Folium Allii tuberosi provides the support on the experimental data as the development and use of flavoring agent and health product.Ma Qingchen; Lv Wenhua; " experimentation of Chinese chive seed oil high temperature resistance and anti-cold service " literary composition that Li Tingli etc. delivered on " Chinese medicine journal " in 2000 shows that the concentration by 0.01% adds Chinese chive seed oil in culture medium, just be born, the fruit bat of not copulation uses etherization, male and female are separately; Put into the test tube of blank group and administration group respectively, 25 of every pipes.Raise after 3 days; Fruit bat is all changed in the empty test tube that does not add culture medium, put into 30min in the constant incubator of (30 4-2) ℃, take out; Observe the maimed situation of fruit bat and calculate mortality rate; The result shows that administration group flies died rate is starkly lower than matched group, has utmost point significant difference between the two; Identical with the high temperature resistance experiment basically in experimentation, administration concentration; Different is, and fruit bat was raised after 3 days, change in the empty test tube that does not have culture medium after, in-10 ℃ of refrigerators, place 50rain and take out; Observe death condition; And the calculating mortality rate, Chinese chive seed oil group flies died rate is starkly lower than the blank group, has utmost point significant difference between the two; The experimental group fruit bat that gives the Folium Allii tuberosi seed thought in article, and under high and low temperature stimulated, mortality rate all was lower than the blank group, and this difference that acts on the sex does not explain that very much the Folium Allii tuberosi seed has the effect of enhancing body nonspecific resistance.
Zhou Haoquan etc. deliver in " deoxythymidine and theophylline are to the preliminary study of mouse asthmatic immunoregulation effect " literary composition on " Anhui medicine " and find, around thymidine intervention group first all air flue tube walls between a large amount of LC infiltrations of matter, the air flue chamber is narrow; Alveolar septum broadening, the interior LC of alveolar space, EOS and macrophage ooze out more, and BALF cytolgical examination Ams ratio also significantly raises; IFN2 γ is significantly higher than asthma group and theophylline group among the BALF at this moment; First, second all white pulp of spleen pathology is that moderate enlarges, LC hyperplasia, and macrophage increases in the red pulp; Show that thymidine maybe be through promoting LC and macrophage hypertrophy; Increase the secretion of IFN2 γ, thereby antagonism pulmonary allergic inflammation is replied the Th2 advantage of asthma and has been obtained partly correcting.Other immunostimulant is applied to asthma, similar effects is also arranged, like BCG.We once used adenosine as intervention factor, reduced lung tissue LC and soaked into and pathological change, obtained obvious effects.
It is following with the research of yang deficiency in " the warming the kidney to activate YANG effect research of Semen Allii Tuberosi extract " literary composition that Anhui Chinese Medicine College king Cheng Yong etc. delivered on the 30th 13 phases of volume of in July, 2005 " CHINA JOURNAL OF CHINESE MATERIA MEDICA " mice to be suffered from a deficiency of the kidney:
1. to the influence of nephrasthenia syndrome model
The Wistar rat carries out two sorrowful orchiectomys under pentobarbital sodium anesthesia, postoperative is intramuscular injection penicillin sodium 20,000 u/kg for three days on end, the administration of dividing into groups then.(1) sham operated rats is all given the equivalent solvent with (2) model group.(3)-(5) Semen Allii Tuberosi ethanol extract group, dosage is respectively 10g/kg, 20g/kg, 40g/kg; (6) androlin group.Except that (6) group is that all the other respectively organize equal ig administration, every day 1 time the subcutaneous injection administration; Continuous 20 days, use appearance (Bangbu radio two factories) to give the local electricity irritation of 4mA at rat penis position with SD-4 type pharmacology physiology then more, the record animal erects incubation period (second; S), the result organizes a t check.
Table 1 Allium tubersum rottl extract is to the preclinical influence of castrated rats erection (n=8,
)
| Group | Dosage (g/kg) | Erection incubation period (s) |
| Sham operated rats | ? | 18.7±9.4 |
| Model group | ? | 32.5±17.3 |
| The androlin group | 0.002 | 19.0±6.4** |
| The Allium tubersum rottl extract group | 40 | 21.3±7.9** |
| The Allium tubersum rottl extract group | 20 | 25.3±14.8* |
| The Allium tubersum rottl extract group | 10 | 29.9±18.5 |
Annotate: compare * P＜0.05, * * P＜0.01 with model group
Result by table 1 can know that Semen Allii Tuberosi extract (at 20g/kg, under the 40g/kg dosage) can improve the irritability of castrated rats penis to electricity irritation, shortens erection incubation period.
2. to the influence of yang deficiency syndrome animal model
Male mice in kunming is divided into 5 groups, 10 every group, is respectively the large, medium and small dose groups of normal group, model group and Semen Allii Tuberosi; Except that normal group, all the other each group adopts all for three days on end that intramuscular injection hydrocortisone 0.25mg/10g causes syndrome of deficiency of kidney-YANG model [3], respectively organizes successive administration before the modeling 7 days 45; Successive administration in the time of modeling; After administration in the 4th day after the modeling 1 hour, write down each treated animal and make body weight, body temperature changing value before and after touching, the free movable number of times in 10 minutes; Low temperature swimming (14 ± 1 ℃) time-to-live, the result sees table 2.
Table 2 Allium tubersum rottl extract is to the influence (n=8,
) of syndrome of deficiency of kidney-YANG
Annotate: compare * P＜0.01 with model group
Table 2 is the result show, Semen Allii Tuberosi extract can obviously prolong the time-to-live of mice in low temperature swimming, increases the autonomic activities number of times; Delay the weight loss trend due to the hydrocortisone; Increase the physiological function of animal body, improve its tolerance, explain that Semen Allii Tuberosi extract has certain supporing yang effect.The effect that has the enhancing body nonspecific resistance with the Semen Allii Tuberosi of bibliographical information is consistent.
The Folium Allii tuberosi seed is classified as the medicine food dual purpose plant natural product by China's Ministry of Public Health.Long period proves through China, and the Folium Allii tuberosi seed does not have the toxicity side effect.Originally declare every of product and contain the 140mg Allium tubersum rottl extract, take 2 every day, be equivalent to edible Allium tubersum rottl extract 280mg every day, 4.0g makes by the Folium Allii tuberosi seed, is equivalent to edible Folium Allii tuberosi seed 4.0g every day.Take 5～15g the every day that is lower than 2010 editions pharmacopeia regulation.
Radix Ginseng:
Radix Ginseng extract in the prescription is that raw material is processed through advanced person's production technology with China's Radix Ginseng.Radix Ginseng is included in " Ministry of Public Health is about the notice of further standard healthy food material management " adnexa 2 and can be used for the article list of health food.The more bibliographical information of Radix Ginseng Radix Ginseng have function of enhancing immunity, for example experiment conclusion is thought in " research that the Folium Ginseng Saponin is regulated chicken immuological function " literary composition of on " Anhui agricultural sciences ", delivering of people such as Luo Yan autumn: the Folium Ginseng Saponin can promote the phagocytic activity of chicken body internal specific production of antibodies and activated mononuclear one macrophage system; " ginsenoside's immunomodulating and antivirus action progress " literary composition that Chu Xiuling delivers on " Chinese veterinarian's medical magazine " is thought: the ginsenoside can promote the growth of immunity of organism organ, thereby directly influences immunity of organisms; The ginsenoside also can influence each stage of hematopoietic cell CFU-GM and hematopoietic stem cell, thus the function of enhance immunity cell, the resistance of raising body; Test in " 3 pairs of Immune Effects of panaxoside Rg " literary composition that people such as imperial court's richness deliver on " China Medicine University's journal " and show: panaxoside Rg 3 can obviously improve mice carbon clearance speed, immune organ weight, serum hemolysin content, splenocyte transforms and N K is active, explains that panaxoside Rg 3 has the effect that improves immunologic function; Experimental result shows in " ginsenoside Rg1's immunologic enhancement " literary composition that people such as Ren Jiehong deliver on " new Chinese medicine and clinical pharmacology ": ginsenoside Rg1 can increase the weight of mouse immune organ and the phagocytic function of macrophage, improves the content of IL-2, complement C3, C4 in the rat blood serum.Explain that Rg1 can improve the laboratory animal immunity of organisms, play the effect that improves the body defense function, immunologic enhancement is promptly arranged; " " progress of ginsenoside's antifatigue effect " literary composition of delivering on the Chinese food health journal shows: the ginsenoside can be through lipid peroxidation that suppresses hydroxyl, oxygen-derived free radicals generation, hydrogen peroxide and the effect of quickening approach performance antioxidant radicals such as free radical scavenging at 2008 the 20th phases the 5th volume for people such as Zhao Wenli; Thereby reach the purpose of alleviating physical fatigue, the ginsenoside also has ability and the active effect of enhances skeletal flesh SOD that raising power exhausts motion back convalescent period mice skeletal free radical resisting; Show in " Radix Ginseng antifatigue effect progress " literary composition that Wang Ying, Cai Donglian deliver on " aminoacid and living resources " magazine and give mice continuous irrigation stomach 7d by various dose, measure the content of mice hemoglobin with the ginseng effective component's Radix Ginseng total saponins (TSPG) that extracts; The result shows, irritates the content that the stomach Radix Ginseng total saponins can increase the white mice hemoglobin, and middle dose groups is the most obvious; Increase by 6.6%; Thereby can significantly increase the each degree of utilizing of breathing of mice to oxygen, can increase Hb content in the erythrocyte by TSPG, and hemoglobin is the main molecules of transporting O2 and CO2 in the blood; Content of hemoglobin increases and both helps in strenuous exercise, to muscular tissue more oxygen being provided; Strengthen the aerobic metabolism energy supply, lactic acid produces and reduces, and quickens the removing of lactic acid simultaneously; Can also in time the CO2 that produces in the muscular tissue be transported to lung and discharge, avoid because the muscle fatigue that pH descends and causes.This has positive role to the generation of delayed motion fatigue and the elimination that accelerates fatigue; Huanghai Sea English is delivered in " ginsenoside's pharmacological action " literary composition on the volume the 1st phase " the up-to-date medical information digest in the world " February the 2nd in 2003 and is shown; From neural, endocrine angle; Chronic fatigue syndrome is relevant with disaster class substance metabolism confusion; The Radix Panacis Quinquefolii ginsenoside feeds mice, and lactic dehydrogenase enzyme activity and hepatic glycogen content and matched group increase more to some extent behind the 15d, 20min behind the mouse movement behind the 29d; The serum lactate level of 5min not only is starkly lower than matched group, and is lower than this group test level.In addition, the ginsenoside can increase the content of myosin adenosinetriphosphataes, and is tired due to relieve chronic fetters.Research shows that the ginsenoside has regulated the confusion of the monoamines material of confirmed fatigue animal to a certain extent, and this mechanism possibly be that Chinese medicine significantly improves one of the fatigue performance of confirmed fatigue animal and reason of ability of learning and memory; People such as Feng Yi Chong deliver on the volume the 2nd phase " Fujian Chinese medicine " April the 40th in 2009 in " ginsenoside Re and Radix Ginseng total saponins are to sports fatigue rat hypothalamus Ach, DA, 5-HT and contain the influence that GABA measures " literary composition and show; The mensuration of sports fatigue rat model hypothalamus neurotransmitter acetylcholine, dopamine, 5-hydroxy tryptamine and alpha-aminobutyric acid content that the equicohesive treadmill exercise of centering duplicates; Find that ginsenoside Re and Radix Ginseng total saponins all can effectively improve the content of acetylcholine and dopamine, reduce the content of 5-hydroxy tryptamine and GABA.Organize comparison with the ginsenoside Re, Radix Ginseng total saponins group rat hypothalamus Ach, 5-HT and GABA have significance to reduce, and DA content has significance to raise; Ceng Meiyi, Li Minmin and the Ministry of Public Health medicine of China Academy of Traditional Chinese Medicine evaluate center Zhao Xiu literary composition " new Chinese medicine with face window pharmacology " March in 1997 the 8th volume the 1st interim " the Radix Ginseng toxicologic study " delivered show: 1. BerteShi 1982) standardization Radix Ginseng journey cream c115 (being called for short G115 down) mixed feeds mice, rat and miniature pig (miniPig) rat, mice single oral dose in the ^ feedstuff and be respectively 2000mg, 3000mg, 4000mg and 5000mg/kg; Lumbar injection dosage is respectively 250mg, 500mg and 1000mg/kg, and the observation period is 14d.The oral GII5LD10 of rat and mice all＞1000mg/kg.The oral chaste tree amount of miniature pig 2000mg/kg observes 7d.Write down its body weight. detect hematology, blood biochemical numerical value, do not see any toxic reaction; 2. Savel (1971) gives rat oral c115, every day dosage be hematology behind the continuous 20d of the 4000mg/kg. training medicine detect and the organ histology microscopy all normal; 3. 32 Beagle Canis familiaris L.s of HessShi etc. (1983) training are fed G115, and every day, dosage was 0,1.5,5.0 and 15mg/kg. 90d when being.Investigated the absolute and relative weight of body weight, food ration, organ of animal; Hematology and blood biochemical are learned and are detected. all do not see any abnormal response that produces by medicine.The histological examination of high dose group and control animals, the result does not see the toxic reaction relevant with medicine yet.Think that daily dose is that the G115 extractum of 15 milligrams/kg does not have the chronic toxicity reaction; Originally declare every of product and contain its content of ginsenoside of Radix Ginseng extract 185.5mg 37.1mg, be equivalent to edible Radix Ginseng extract 371mg every day, production yield 10% is equivalent to edible Radix Ginseng 3.71g every day, takes 3～9g the every day that meets 2010 editions pharmacopeia regulations.
Radix Morindae Officinalis
Radix Morindae Officinalis (MorindaofficinalisHow) is a Rubiaceae Rubia plant, and its fleshy tap root is one of China's four Da Nan medicines, has the effect of invigorating primordial QI, settling five organs, bone and muscle strengthening, strong waist, is the conventional Chinese medicine of warming the kidney to invigorate YANG.Rat is had weightening finish to Radix Morindae Officinalis decocting liquid and antifatigue effect I draws, and can significantly increase the white mice body weight, prolong lasting swimming time t61, improves the motor capacity on cat net, is reduced in the oxygen consumption under the anaerobic condition, prolongs the anoxia enduring persistent period.Researchs such as Pan Xinyu find that also Radix Morindae Officinalis can improve the function of motion rat anti free-radical oxidation, and the rat motor ability is obviously strengthened.Increasing the Radix Morindae Officinalis water decoction can improve serum superoxide dismutases (SOD) and glutathion peroxidase (GSH-Px) activity and reduce serum malonaldehyde (MDA) content; Think that Radix Morindae Officinalis can or promote body to produce the endogenous antioxidant through supplemented with exogenous property antioxidant; Remove free radical; Suppress lipid peroxidation injury, slow down aging 1121.Crust halberd element can improve old and feeble rat model SOD and GSH-Px is active, observes the content that crust halberd element can improve NO in its cerebral tissue simultaneously, and the glucose level of rising cerebral tissue reduces lipid peroxide (LPO) and lipofuscin and generates and gather.Think that crust halberd element possibly be that NO descends in the old and feeble rat cerebral tissue through suppressing, improve the activity of cerebral tissue glucose metabolism level and antioxidase, suppress lipid peroxidation and gathering of lipofuscin and an anti-aging effects.The Radix Morindae Officinalis water extract has obvious intervention effect to people's sperm peroxide injury due to the active oxygen, and the sperm motility function is had protective effect.The Radix Morindae Officinalis alcohol extract can increase old and feeble male rat epididymal sperm sum, the sperm rate of living; Reduce abnormal sperm rate; And resist significantly that sperm rate alive that Propranolol causes reduces and the rising of abnormal sperm rate, and these effects maybe to improve in the old and feeble rat testis SOD activity relevant with the Radix Morindae Officinalis alcohol extract.The Radix Morindae Officinalis ethanol extract can reduce the sperm basis abnormal rate of male white mouse through acting on spermatogonium and primary spermatocyte.Crust halberd polysaccharide can improve fruit bat property vigor, and significantly improves the eclosion rate of fruit bat newborn larvae, thinks that crust halberd polysaccharide has tangible kidney invigorating and YANG supporting effect.
1, the Radix Morindae Officinalis oligosaccharide is to the influence of fruit bat property vigor:
Table 3 shows that the Radix Morindae Officinalis oligosaccharide can improve the property vigor of fruit bat, and fruit bat type copulation percentile rank is 3 groups＞2 groups＞1 group, and its effect is strong and weak to be proportionate with the Radix Morindae Officinalis concentration of oligosaccharide.The Radix Morindae Officinalis medical material does not influence fruit bat type copulation percentage rate when this experimental concentration; Positive control drug " NANBAO " can improve fruit bat type copulation percentage rate.
Table 3 Radix Morindae Officinalis oligosaccharide is to the influence of fruit bat property vigor
2, the Radix Morindae Officinalis oligosaccharide is to the influence of fruit bat eclosion rate:
Table 4 shows that the Radix Morindae Officinalis oligosaccharide can significantly improve the larva eclosion rate, with matched group relatively, its eclosion rate can improve 25.42%-35.39%, but along with the rising of Radix Morindae Officinalis concentration of oligosaccharide, the larva eclosion rate is slightly on a declining curve.Radix Morindae Officinalis medical material and NANBAO all can significantly improve the larva eclosion rate.
Table 4 Radix Morindae Officinalis oligosaccharide is to the influence of fruit bat eclosion rate
(1) under the used dosage of this test, the Radix Morindae Officinalis aqueous extract does not show the effect that fruit bat property vigor increases.Yet from Radix Morindae Officinalis, extract, separate the Radix Morindae Officinalis oligosaccharide that obtains and then improved fruit bat property vigor.Mensuration result shows that used Radix Morindae Officinalis medical material oligosaccharide content is 13.87%, so medical material group concentration of oligosaccharide should be close with oligomeric group of Radix Morindae Officinalis.Thereby prompting, ' but effect that other contained composition interfere Radix Morindae Officinalis oligosaccharide of Radix Morindae Officinalis medical material improve fruit bat property vigor;
(2) because the experiment of fruit bat property vigor only can reflect fruit sexual intercourse distribution percentage in the short-term (11min); Can not investigate male fruit bat semen quality and long-time interior fruit bat number of copulations; Therefore, the research contents of newborn larvae eclosion rate has been set up in this experiment, to remedy the deficiency of originality vigor experiment.Plumage
Cordyceps
Cordyceps and Radix Ginseng, Cornu Cervi Pantotrichum are equally celebrated for their achievements, are one of Chinese medicine SANBAO, as medicine and the existing hundreds of years history of health product, by the extensive understanding and accepting of people institute.China is discovery and more remote at the medicinal history of pharmaceutically using Cordyceps country the earliest, particularly Periostracum cicadae and Cordyceps.China is for the research of Cordyceps militaris (L.) Link., and the beginning is stated from " Xinhua's book on Chinese herbal medicine outline " book, puts down in writing its effect and is: " sweet in the mouth, property are put down, the effect of the lung benefiting the kidney invigorating is arranged, mending marrow, hemostasis and phlegm "." Chinese medicine sea " thought its " meridian distribution of property and flavor, sweet, flat is gone into lung kidney two warps ", and its function has: the YANG invigorating of (one) kidney tonifying, and the sweet flat kidney-replenishing of these article, beneficial marrow is controlled deficiency of kidney yin, vertigo and tinnitus, forgetfully is insomnia, disease such as soreness of the waist and knees, impotence and premature ejaculation; (2) not only kidney-replenishing but also tonifying the lung the moon are protected the lung kidney tonifying, and secret lean gas has better curative effect to lung kidney deficiency, chronic cough dyspnea due to deficiency, phthisical cough expectorant blood person." national Chinese herbal medicine compilation " record: Cordyceps militaris (Cordyceps militaris (L.) Link.) sporophore also can be used as Cordyceps and is used as medicine.
1, the Cordyceps preparation is to the influence of yang deficiency mice:
1.1 the Cordyceps preparation is to the influence of yang deficiency syndrome mice low temperature swimming time-to-live: heavy dose of hydrocortisone can cause the mice yang deficiency syndrome, makes that mice is cold-resistant, fatigue resistance descends.Chinese caterpillar fungus preparation I and II can obviously postpone the mice low temperature swimming time-to-live; And along with the prolongation of Time of Administration; The time-to-live of mice low temperature swimming also obviously prolongs; After taking 1 month, the Chinese caterpillar fungus preparation I group low temperature swimming time-to-live prolongs 123.87s than yang deficiency group, and Chinese caterpillar fungus preparation II group prolongs 43.53s.The Cordyceps fermented liquid group also has certain prolongation, but effect is weaker than other two sample.See table 5.
Table 5 Cordyceps preparation is to the influence (n=10) of yang deficiency syndrome animal
※ P＜0.01, each group contrasts with the yang deficiency group respectively
1.2 the Cordyceps preparation is to the influence of yang deficiency syndrome mice autonomic activities number: after feeding 30 days; Yang deficiency syndrome mice autonomic activities number of times is starkly lower than the normal control group; Cordyceps preparation I group mice autonomic activities number of times is than Duoing 7.8 times in the yang deficiency group 10min; Chinese caterpillar fungus preparation I group is than yang deficiency group activity 12.2 times often, and Chinese caterpillar fungus preparation II organizes many 9.2 times.Along with the prolongation of Time of Administration, effect is obvious.
1.3 the Cordyceps preparation is to the influence of yang deficiency syndrome mice body weight: after taking sample 15d, yang deficiency group mice body weight is starkly lower than normal group, and sample sets increases than yang deficiency group body weight to some extent, but not remarkable; After 1 month, 3 sample sets body weight are apparently higher than the yang deficiency group, and especially Chinese caterpillar fungus preparation II group effect is very obvious, and along with Time of Administration prolongs, effect is more obvious.
1.4 the Cordyceps preparation is putd question to influence to the yang deficiency syndrome mice: the body temperature of normal mouse is at 37-39 ℃; Hydrocortisone does not have obvious influence to the body temperature of mice; Take the mouse temperature of Cordyceps fermented liquid and Chinese caterpillar fungus preparation group and compare no significant change with normal control group, yang deficiency group, visible sample is little to the mouse temperature influence.
1.5 the Cordyceps preparation is to the influence of yang deficiency mice androgen: yang deficiency group mice androgen level acutely descends, and takes 3 kinds of samples after 1 month, the androgen of mice all increases to some extent, but still is lower than normal group.Take sample after 1.5 months, the androgen of 3 sample sets returns to the level of normal mouse, and wherein the androgen level of Chinese caterpillar fungus preparation II group increases obviously, is significantly higher than normal group.
2, the Cordyceps preparation is to the influence of the animal of suffering from a deficiency of the kidney
2.1 tonifying YANG experiment: the result sees that table 6. takes sample 30d, and the erection of castrated rats promptly returns to the time of normal rat incubation period, is significantly shorter than castration model group (P＜0.01).
Table 6 Cordyceps preparation is to the influence of castrated rats penile erectile function
※ P＜0.01 is compared with the castration model group.
1.6 the influence to the animal genitals weight of suffering from a deficiency of the kidney: each genitals's of the rat of suffering from a deficiency of the kidney (castrated rats) weight is starkly lower than normal rat.Take 3 kinds of samples after 30 days, the preputial glands of mice, levator ani and prostate add the weight of seminal fluid capsule apparently higher than the castration model group, and along with feeding time lengthening, weight also obviously increases, and wherein Chinese caterpillar fungus preparation I group effect is best.See table 7.
Table 7 Cordyceps preparation is to the influence (n=8) of the animal of suffering from a deficiency of the kidney
Compare with each group respectively #P＜0.01, normal control group; ※ P＜0.01, castration model group are relatively
Xu Xi, etc. to intraperitoneal injection (ip) way of telling Cordyceps boiling alcohol extract 1-3g / (kg.d) × 3 to mice, and make their peripheral blood and spleen lymphocyte proliferation, especially the proliferation of T-helper cells significantly, TH / TS ratio increased, the spleen cells produce interleukin -2 (TL-2) enhanced ability, and to natural killer (NK) cell activity increased.Wang Genwei carries out the mensuration of macrophage phagocytic function to the mices of taking Cordyceps water extract 3 week, and the result shows that macrophage phagocytic function significantly strengthens, and presents dose-response relationship.The PHA expression of inducing IL-2R alone or synergistically such as the research surface Cordyceps polysaccharides in quiet main road etc.; Promote the generation of solubility IL-2R; But IL-2, the active selective inhibitory action of interferon gamma (IFN-γ) that PHA is induced; It is worked in coordination with or inhibitory action all is dose dependent, and the prompting Cordyceps polysaccharide has two-way immunoregulation effect to the PBLC of In vitro culture.
Herba Cistanches
Herba Cistanches is the kidney invigorating and YANG supporting Chinese medicine of using always, and the Herba Cistanches of have the kidney invigorating and essence nourishing, moisturizing is the kidney invigorating and YANG supporting Chinese medicine of using always, the function of have the kidney invigorating and essence nourishing, moisturizing.Because the particularity of Herba Cistanches parasitic growth breeding, evident in efficacy in addition and by artificial because the particularity of Herba Cistanches parasitic growth breeding is evident in efficacy in addition.The comparison of " insufficiency of kidney-YANG " mice cold-resistant function that hydrocortisone is caused.
Choose 60 of the male mice in kunming of the male mice in kunming of body weight 28 ± 2g,, be divided into 6 groups at random, 10 every group.Except that blank (normally) matched group, all the other only respectively organize equal intramuscular injection hydrogenation.0.8mg/10g.d successive administration 10 days, to " insufficiency of kidney-YANG " model group mice major part occur hair loose or lose hair or feathers, become thin, spiritlessness and weakness and cold physique tail are cold etc. typically till " insufficiency of kidney-YANG " symptom.Simultaneously blank (normally) matched group of moulding, model group are irritated the normal saline of stomach 0.2ml/10g.d; Irritate the stomach group respectively for other 4 groups and irritate stomach 0.2ml/10g.d respectively; Concentration is 0.5g/ml, 1.0g/ml Herba Cistanches decocting liquid, and concentration is 0.5g/ml, 1.0g/ml Cistanche Tubulosa decocting liquid.Behind the last administration 1h with animal according to grouping, be put in respectively in the different big cartons, place constant temperature refrigerator (5----7 ℃), record animal life span at low temperatures, result see in the table 2,
Table 8 Herba Cistanches and the effect of Cistanche Tubulosa kidney invigorating and YANG supporting are relatively
Shown by The above results: two kinds all have the effect of certain warming and recuperating the kidney-YANG; Herba Cistanches and Cistanche Tubulosa decocting liquid all can obviously increase the body weight of " insufficiency of kidney-YANG " model mice; The cold-resistant time of " insufficiency of kidney-YANG " model mice is obviously prolonged, and its Signs is had improvement to a certain degree.It is thus clear that the two all has certain yang invigorating functions.
1, Herba Cistanches is to the influence of sperm concentration, motility rate, the speed of service and abnormal rate in the seminal fluid.
Table 9 Herba Cistanches is to the influence of sperm D, A, T, V
2, Herba Cistanches is to the influence of fructose content in the mice seminal fluid
The variation of fructose content in the table 10 mice seminal fluid
4, Herba Cistanches is to the succinate dehydrogenase (SDH) of mouse testis and epididymis, the influence of non-specific lipase (NSE)
The SDH reaction is all arranged in succinate dehydrogenase (SDH) the spermatogenic cell kytoplasms at different levels, and wherein stronger with spermatogonium, the reaction of Interstitial cell is extremely strong.The SDH positive particle is dispersed in distribution in the epididymal duct epithelial cell, and is more with the supranuclear region.Medication group SDH reaction is better than matched group.
Table 11 Herba Cistanches compares mouse testis and epididymis SDH, NSE response strength
The SDH of medication group, NSE are apparently higher than matched group P＜0.05
Spermatogenesis is the complex process of a multidate, comprising the abnormal three phases of the mitosis of spermatogonium, spermatocytal meiosis and spermatid.All there is its special metabolic type in each stage.The division of spermatogenic cells at different levels and spermatogenesis need the enough nutrient substance and the adjusting of endocrine hormone in the seminiferous tubule.Motherland's traditional medicine thinks that Herba Cistanches has kidney invigorating and YANG supporting effect preferably, then can present the effect of androgen and GTH appearance, with the function of endocrine regulation gland axle.Androgen is a requisite hormone in the spermatogenesis process.Epididymis is the further ripe microenvironment of growing and breaking up of sperm; Sperm depends on the synergism of epididymal in this process, epithelial secretion, absorption and substance transportation activity mainly are the microenvironments that the adjustable pipe intracavity is suitable for sperm development and differentiation and storage and tranquillization.The content of fructose is the important composition of reflection epididymal function in the refining, and medication group fructose content is apparently higher than matched group.SDH belongs to the enzyme of succinate oxidation enzyme system; In mitochondrion, arrange chaining; SDH is first enzyme of this system, is present in the cell of all aerobic respirations and the mitochondrial membrane strong bonded; Be most important enzyme in the dehydrogenase, in group reaction, be commonly used to reflect the situation of tricarboxylic acid cycle and become marker enzyme.Active hydrolysis and the steroidal with cholesterol of NSE is synthetic relevant, is commonly used to weigh the function of interstitial cell.The medicine number of SDH, NSE strong positive reaction is apparently higher than matched group in medication group testis and the epididymis, proves that Herba Cistanches really can promote testicular spermatogenic function, improve the microenvironment of epididymis.For the mechanism of Herba Cistanches kidney invigorating and YANG supporting effect provides the reliable morphological foundation.
Radix Ginseng
Radix Ginseng is included in " Ministry of Public Health is about the notice of further standard healthy food material management " adnexa 2 and can be used for the article list of health food.
The more bibliographical information of Radix Ginseng Radix Ginseng have function of enhancing immunity, for example experiment conclusion is thought in " research that the Folium Ginseng Saponin is regulated chicken immuological function " literary composition of on " Anhui agricultural sciences ", delivering of people such as Luo Yan autumn: the Folium Ginseng Saponin can promote the phagocytic activity of chicken body internal specific production of antibodies and activated mononuclear-macrophage system." ginsenoside's immunomodulating and antivirus action progress " literary composition that Chu Xiuling delivers on " Chinese veterinarian's medical magazine " is thought: the ginsenoside can promote the growth of immunity of organism organ, thereby directly influences immunity of organisms; The ginsenoside also can influence each stage of hematopoietic cell CFU-GM and hematopoietic stem cell, thus the function of enhance immunity cell, the resistance of raising body.Test in " 3 pairs of Immune Effects of panaxoside Rg " literary composition that people such as imperial court's richness deliver on " China Medicine University's journal " and show: panaxoside Rg 3 can obviously improve mice carbon clearance speed, immune organ weight, serum hemolysin content, splenocyte transforms and NK is active, explains that panaxoside Rg 3 has the effect that improves immunologic function.Experimental result shows in " ginsenoside Rg1's immunologic enhancement " literary composition that people such as Ren Jiehong deliver on " new Chinese medicine and clinical pharmacology ": ginsenoside Rg1 can increase the weight of mouse immune organ and the phagocytic function of macrophage, improves the content of IL-2, complement C3, C4 in the rat blood serum.Explain that Rg1 can improve the laboratory animal immunity of organisms, play the effect that improves the body defense function, immunologic enhancement is promptly arranged." " progress of ginsenoside's antifatigue effect " literary composition of delivering on the Chinese food health journal shows that the ginsenoside can be through lipid peroxidation that suppresses hydroxyl, oxygen-derived free radicals generation, hydrogen peroxide and the effect of quickening approach performance antioxidant radicals such as free radical scavenging to people such as Zhao Wenli at 2008 the 20th phases the 5th volume; Thereby reach the purpose of alleviating physical fatigue, the ginsenoside also has ability and the active effect of enhances skeletal flesh SOD that raising power exhausts motion back convalescent period mice skeletal free radical resisting.Show in " Radix Ginseng antifatigue effect progress " literary composition that Wang Ying, Cai Donglian deliver on " aminoacid and living resources " magazine with the ginseng effective component's Radix Ginseng total saponins (TSPG) that extracts; Give mice continuous irrigation stomach 7d by various dose, measure the content of mice hemoglobin, the result shows; Filling stomach Radix Ginseng total saponins can increase the content of white mice hemoglobin; Middle dose groups is the most obvious, increases by 6.6%, thereby can significantly increase the each degree of utilizing of breathing oxygen of mice; Can increase Hb content in the erythrocyte by TSPG, and hemoglobin is to transport O in the blood
2And CO
2Main molecules, content of hemoglobin increases and both helps in strenuous exercise, to muscular tissue more oxygen being provided, and strengthens the aerobic metabolism energy supply, lactic acid produces and reduces, and quickens the removing of lactic acid simultaneously, can also be in time with the CO that produces in the muscular tissue
2Be transported to lung and discharge, avoid because the muscle fatigue that pH descends and causes.This has positive role to the generation of delayed motion fatigue and the elimination that accelerates fatigue.Huanghai Sea English is delivered in " ginsenoside's pharmacological action " literary composition on the volume the 1st phase " the up-to-date medical information digest in the world " February the 2nd in 2003 and is shown; From neural, endocrine angle; Chronic fatigue syndrome is relevant with disaster class substance metabolism confusion; The Radix Panacis Quinquefolii ginsenoside feeds mice, and lactic dehydrogenase enzyme activity and hepatic glycogen content and matched group increase more to some extent behind the 15d, 20min behind the mouse movement behind the 29d; The serum lactate level of 5min not only is starkly lower than matched group, and is lower than this group test level.In addition, the ginsenoside can increase the content of myosin adenosinetriphosphataes, and is tired due to relieve chronic fetters.Research shows that the ginsenoside has regulated the confusion of the monoamines material of confirmed fatigue animal to a certain extent, and this mechanism possibly be that Chinese medicine significantly improves one of the fatigue performance of confirmed fatigue animal and reason of ability of learning and memory.People such as Pan Huashan deliver on the volume the 2nd phase " Fujian Chinese medicine " April the 40th in 2009 in " ginsenoside Re and Radix Ginseng total saponins are to sports fatigue rat hypothalamus Ach, DA, 5-HT and contain the influence that GABA measures " literary composition and show; The mensuration of sports fatigue rat model hypothalamus neurotransmitter acetylcholine, dopamine, 5-hydroxy tryptamine and alpha-aminobutyric acid content that the equicohesive treadmill exercise of centering duplicates; Find that ginsenoside Re and Radix Ginseng total saponins all can effectively improve the content of acetylcholine and dopamine, reduce the content of 5-hydroxy tryptamine and GABA.Organize comparison with the ginsenoside Re, Radix Ginseng total saponins group rat hypothalamus Ach, 5-HT and GABA have significance to reduce, and DA content has significance to raise.Ceng Meiyi, Li Minmin and the Ministry of Public Health medicine of China Academy of Traditional Chinese Medicine evaluate center Zhao Xiu literary composition " new Chinese medicine with face window pharmacology " March in 1997 the 8th volume the 1st interim " the Radix Ginseng toxicologic study " delivered show: 1. BerteShi (1982) mixes standardization Radix Ginseng journey cream c115 (being called for short G115 down) and feeds mice, rat and miniature pig (miniPig) rat, mice single oral dose in the feedstuff and be respectively 2000mg, 3000mg, 4000mg and 5000mg/kg; Lumbar injection dosage is respectively 250mg, 500mg and 1000mg/kg, and the observation period is 14d.The oral GII5 LD of rat and mice
10All＞1000mg/kg.The oral chaste tree amount of miniature pig 2000mg/kg observes 7d.Write down its body weight, detection hematology, blood biochemical numerical value, do not see any toxic reaction; 2. Savel (1971) gives rat oral c115, and every day, dosage was 4000mg/kg.Hematology's detection and organ histology microscopy behind the 20d training medicine is all normal continuously; 3. HessShi etc. (1983) feeds G115 for 32 Beagle Canis familiaris L.s, and every day, dosage was 0,1.5,5.0 and 15mg/kg.For the time 90d.Investigated the absolute and relative weight of body weight, food ration, organ of animal; Hematology and blood biochemical are learned and are detected, and all do not see any abnormal response that is produced by medicine.The histological examination of high dose group and control animals, the result does not see the toxic reaction relevant with medicine yet.Think that daily dose is that the G115 extractum of 15mg/kg does not have chronic toxicity reaction pregelatinized Starch, microcrystalline Cellulose, Icing Sugar, magnesium stearate
Consider the course of processing operability and medicine mouthfeel we selected for use food additive pregelatinized Starch, microcrystalline Cellulose, Icing Sugar, magnesium stearate as antiplastering aid and flow aid, sweeting agent, disintegrating agent, show in " microcrystalline Cellulose---a kind of multi-functional macromolecular material " literary composition of on " Guangzhou chemical industry " 1993 the 21st the 3rd phases of volume, delivering according to the Zhu Yu of Guangzhou Inst of Chemistry, Chinese Academy of Sciences qin, Tang Liegui, Pan Songhan: microcrystalline Cellulose can be used as antiplastering aid.The microcrystalline Cellulose addition meets GB2760 " food additive use sanitary standard " for 11% of prescription, and microcrystalline Cellulose toxicity property ADI does not do particular provisions (FAO/WHO, 1994), makes its whole prescription have more reasonability and science like this.
Several kinds of raw materials are assisted mutually in whole prescription and are deposited mutually more than this specific embodiment, bring out the best in each other, and make full side present effect preferably, and product has tangible kidney supplementing yang invigorating health care function through these article of function test proof.
Claims (6)
1. the health medicine of a kidney invigorating and YANG supporting; Its prescription is than being leek extract 6-10g, Radix Morindae Officinalis 4-9g, Cordyceps 4-9g, Herba Cistanches 6-12g, Radix Ginseng 4-9g, beta-schardinger dextrin-3-8g, pregelatinized Starch 4-10g, microcrystalline Cellulose 3-8g, Icing Sugar 6-15g, magnesium stearate 0.3-1g.
2. health medicine according to claim 1; It is characterized in that; The prescription ratio of this medicine is leek extract 6g, Radix Morindae Officinalis 4g, Cordyceps 4g, Herba Cistanches 2g, Radix Ginseng 4g, beta-schardinger dextrin-3g, pregelatinized Starch 4g, microcrystalline Cellulose 3g, Icing Sugar 6g, magnesium stearate 0.3g.
3. health medicine according to claim 1; It is characterized in that; The prescription ratio of this medicine is leek extract 10g, Radix Morindae Officinalis 9g, Cordyceps 9g, Herba Cistanches 12g, Radix Ginseng 9g, beta-schardinger dextrin-8g, pregelatinized Starch 10g, microcrystalline Cellulose 8g, Icing Sugar 15g, magnesium stearate 1g.
4. health medicine according to claim 1; It is characterized in that; The prescription ratio of this medicine is leek extract 8g, Radix Morindae Officinalis 6g, Cordyceps 5.5g, Herba Cistanches 7.2g, Radix Ginseng 6.7g, beta-schardinger dextrin-5.6g, pregelatinized Starch 6.4g, microcrystalline Cellulose 5.5g, Icing Sugar 7.8g, magnesium stearate 0.56g.
5. according to each described health medicine of claim 1-4; It is characterized in that; The prescription ratio of this medicine does; The effective ingredient ratio of this medicine is preferably: the 100g medicine contains effective composition nucleoside 1200mg, the plain 4000mg of Radix Morindae Officinalis, Paecilomyces hepiali Chen et Dai Mycelia 700mg, the plain 4500mg of Herba Cistanches, ginsenoside 2000mg.
6. a method for preparing each said health medicine of claim 1-5 is characterized in that, earlier Radix Morindae Officinalis, Cordyceps, Herba Cistanches, Radix Ginseng is pulverized respectively; Cross the 60-80 mesh sieve, the various drug powders after weighing is pulverized mix with other supplementary material, incorporation time control 45-50 minute; Carrying out capsule then fills; Filling process is filled the weight of medicated powder according to inner quality standard control, selects, polishing, inner packing, outer package, preferably according to touchstone check warehouse-in again.
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| CN102919845A (en) * | 2012-11-21 | 2013-02-13 | 济南老来寿生物股份有限公司 | Health-care food for relieving physical fatigue |
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| CN108159262A (en) * | 2018-01-31 | 2018-06-15 | 福建启元堂生物技术有限公司 | A kind of preparation method and application of the composition of warm kidney kidney tonifying, the composition |
| CN116059279A (en) * | 2022-12-05 | 2023-05-05 | 张大文 | Ginseng radix morinda officinalis herba cistanches tablet |
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